#Vector Purification Market Trend
Explore tagged Tumblr posts
colinwilson11 · 2 months ago
Text
Vector Purification Market To Surge At 21% CAGR Aided By Rising Cancer Research Activities
Tumblr media
The Vector Purification Market is driven by the increasing prevalence of cancer and the need for therapeutic vectors in gene therapy and vaccine development. The vector purification process helps in isolating the recombinant virus or non-viral vectors from host cell lysates or media and removes any contaminating host cell components. This purification is crucial for ensuring the safety and efficacy of engineered vectors in therapeutics and vaccine applications. Vectors are essential tools used for introducing new genetic material into cells. Common vectors include viruses and non-viral systems such as plasmids, which can be engineered to carry therapeutic genes into targeted host cells. Purification removes any contaminating toxic cellular components or proteins, live or dead host cells, media components, and impurities from the final vector preparation.
The Vector Purification Market is estimated to be valued at US$ 336 Mn in 2024 and is expected to exhibit a CAGR of 21% over the forecast period 2024-2031.
Key Takeaways
Key players operating in the vector purification market are Agilent Technologies, BIA Separations, Bio-Rad Laboratories, Merck, and Thermo Fisher Scientific.
Growing incidence of cancer and genetic disorders is fueling the demand for gene and cell therapies with engineered vectors. This is driving significant research investments into developing advanced vector systems, propelling the need for large-scale vector purification.
Technological advancements include automated large-scale purification systems using affinity chromatography, size-exclusion chromatography, and other methods optimized for clinical-grade vectors. Companies are also developing specialized resins and kits tailored for specific vector platforms to streamline purification workflows.
Market Trends
Growing adoption of adeno-associated viral vectors - AAV vectors have emerged as the preferred gene delivery tool due to their low pathogenicity and ability to transduce non-dividing cells. This is spurring increased R&D utilizing AAV systems.
Continuous processing technologies - Continuous multi-column purification systems coupled with in-line monitoring are being introduced to enhance process scalability and vector yields for clinical and commercial applications.
Market Opportunities
Developing economies in Asia Pacific and Latin America present lucrative opportunities for vector purification product suppliers and contract service providers, driven by increased government funding for cell and gene therapy research.
Custom purification solutions - Partnering with clinical developers to provide tailored resins, chromatography methods and single-use kits optimized for specific vectors could capture a larger share of the high-growth advanced therapy market.
Impact of COVID-19 on Vector Purification Market Growth
The COVID-19 pandemic has significantly impacted the growth of the vector purification market. With lockdowns imposed across various regions, research activities slowed down drastically impacting the demand for vector purification kits, columns and other products. Social distancing measures also disrupted the supply chain to some extent. However, with the pandemic accelerating research on vaccine and therapeutics development, the need for DNA and RNA purification increased rapidly. Several biopharma companies accelerated their clinical trials and manufacturing operations focusing on COVID-19 treatment and prevention.
Post pandemic, the vector purification market is expected to witness robust growth. With rising investments to boost preparedness for future pandemics, research focusing on vaccine development and gene therapy is likely to increase. Several contract manufacturing and custom services companies have also expanded their capabilities to support clinical trials and commercial manufacturing of cell and gene therapies. This would drive the demand for high quality and reproducible purification solutions. Additionally, continued expansion of regenerative medicine applications and advancement of gene editing tools would further propel the market growth. Key players are actively investing in portfolio expansion and automation technology to increase throughput and reproducibility.
Europe contributed the largest revenue share to the Vector Purification Market owing to significant research focus and presence of major market players. However, Asia Pacific represented the fastest growing regional market and is anticipated to overtake Europe during the forecast period. This can be attributed to rising healthcare investments, increasing biotech research workforce and strengthening manufacturing capabilities in major Asian countries including China, India and South Korea. The growing geriatric population base and rising incidence of genetic disorders also present lucrative opportunities.
As countries seek to reduce dependence on imported vaccines and biologics, focus is growing on boosting domestic manufacturing capabilities. This presents immense opportunities for vector purification solution providers to assist various regional and contract manufacturing organizations with technology transfer and process development projects. Key strategies for market players should include partnerships with regional clinical research organizations, establishment of local technical centres and development of affordable product offerings.
Get more insights on this topic:  https://www.trendingwebwire.com/vector-purification-market-is-estimated-to-witness-high-growth-owing-to-automation-technologies/
Author Bio:
Alice Mutum is a seasoned senior content editor at Coherent Market Insights, leveraging extensive expertise gained from her previous role as a content writer. With seven years in content development, Alice masterfully employs SEO best practices and cutting-edge digital marketing strategies to craft high-ranking, impactful content. As an editor, she meticulously ensures flawless grammar and punctuation, precise data accuracy, and perfect alignment with audience needs in every research report. Alice's dedication to excellence and her strategic approach to content make her an invaluable asset in the world of market insights. (LinkedIn: www.linkedin.com/in/alice-mutum-3b247b137 )
What Are The Key Data Covered In This Vector Purification Market Report?
:- Market CAGR throughout the predicted period
:- Comprehensive information on the aspects that will drive the Vector Purification Market's growth between 2024 and 2031.
:- Accurate calculation of the size of the Vector Purification Market and its contribution to the market, with emphasis on the parent market
:- Realistic forecasts of future trends and changes in consumer behaviour
:- Vector Purification Market Industry Growth in North America, APAC, Europe, South America, the Middle East, and Africa
:- A complete examination of the market's competitive landscape, as well as extensive information on vendors
:- Detailed examination of the factors that will impede the expansion of Vector Purification Market vendors
FAQ’s
Q.1 What are the main factors influencing the Vector Purification Market?
Q.2 Which companies are the major sources in this industry?
Q.3 What are the market’s opportunities, risks, and general structure?
Q.4 Which of the top Vector Purification Market companies compare in terms of sales, revenue, and prices?
Q.5 Which businesses serve as the Vector Purification Market’s distributors, traders, and dealers?
Q.6 How are market types and applications and deals, revenue, and value explored?
Q.7 What does a business area’s assessment of agreements, income, and value implicate?
*Note: 1. Source: Coherent Market Insights, Public sources, Desk research 2. We have leveraged AI tools to mine information and compile it
0 notes
healthcaremarketanalysis · 5 months ago
Text
The Viral Vector Manufacturing Market: A Growing Force in Biotechnology
Viral vector and plasmid DNA manufacturing market includes the products and services used for development and manufacturing of viral vector and plasmid DNA. Viral vectors are used to deliver genetic material into cells, while plasmid DNA is used to produce proteins or other molecules that can be used as vaccines or therapeutics. These technologies are being increasingly used to develop treatments for a range of diseases, including cancer, genetic disorders, and infectious diseases.
The global viral vector manufacturing market in terms of revenue was estimated to be worth $5.5 billion in 2023 and is poised to reach $12.8 billion by 2028, growing at a CAGR of 18.2% from 2023 to 2028.
Download PDF Brochure:
Market Dynamics
1. Market Drivers:
Increasing Gene Therapy Approvals: The approval of gene therapies like Luxturna and Zolgensma has spurred interest and investment in viral vector manufacturing.
Rising Prevalence of Genetic Disorders: With a growing understanding of genetic diseases, there is an increased demand for effective treatments, driving the need for viral vectors.
Advancements in Vaccine Development: The COVID-19 pandemic highlighted the importance of viral vector vaccines, such as those developed by AstraZeneca and Johnson & Johnson, boosting the market.
2. Market Challenges:
Complex Manufacturing Processes: Producing viral vectors is technically challenging and requires stringent quality control to ensure safety and efficacy.
High Production Costs: The cost of producing viral vectors is high, which can limit accessibility and scalability.
Regulatory Hurdles: Navigating the regulatory landscape is complex, with rigorous standards to ensure patient safety.
3. Emerging Trends:
Innovations in Production Technologies: Advances in bioreactor design, purification processes, and scalable manufacturing technologies are improving efficiency and reducing costs.
Collaboration and Partnerships: Increased collaboration between biotech companies, academic institutions, and contract manufacturing organizations (CMOs) is driving innovation and capacity expansion.
Focus on Rare Diseases: There is a growing emphasis on developing therapies for rare genetic disorders, often overlooked by traditional pharmaceuticals.
Key Players in the Market
Lonza Group AG (Switzerland), Merck KGaA (Germany), Thermo Fisher Scientific Inc. (US), Charles River Laboratories International, Inc. (US), Catalent Inc. (US), WuXi AppTec (China), FUJIFILM Corporation (Japan), GenScript Biotech Corporation (US), Takara Bio Inc. (Japan), Oxford Biomedica (UK), Novartis AG (Switzerland), Precision Biosciences (US), Bluebird Bio, Inc. (US), Sartorius AG (Germany), Danaher Corporation (US), SIRON Biotech (Germany), VGXI, Inc. (US), Waisman Biomanufacturing (US), Kaneka Eurogentec S.A. (Belgium), PlasmidFactory GmbH (Germany), ATUM (US), Addgene (US), Cell and Gene Therapy Catapult (UK), Batavia biosciences (Netherlands), and Altogen Biosystems (US).
Regional Analysis:
The North America region catered the largest share of the viral vector and plasmid DNA manufacturing market in 2022.
The viral vector and plasmid DNA manufacturing market in North America has experienced significant growth in recent years, showcasing a robust expansion trajectory, owing to the well-established research infrastructure, strong pharmaceutical and biotech industry, increasing government support for life science research, technological advancements in viral vector and plasmid DNA manufacturing technologies, and collaborative initiatives contribute to the growth of the viral vector and plasmid DNA manufacturing market in the North America region. Additionally, North America faces a significant burden of chronic diseases, including cancer, cardiovascular diseases, and neurological disorders. The increasing prevalence of chronic diseases in the region drives the demand for viral vector and plasmid DNA manufacturing for both research and clinical applications.
Future Prospects
The future of the viral vector manufacturing market looks promising, with several factors contributing to its growth:
Technological Advancements: Continued innovation in manufacturing technologies is expected to improve efficiency, reduce costs, and enhance the scalability of viral vector production.
Regulatory Support: Evolving regulatory frameworks and support for advanced therapies will facilitate smoother approval processes and market entry.
Expanding Therapeutic Applications: Beyond gene therapy and vaccines, viral vectors are being explored for applications in oncology, neurology, and rare diseases, broadening their market potential.
Conclusion
The viral vector manufacturing market is poised for significant growth, driven by advancements in gene therapy, vaccine development, and biotechnological innovations. Despite facing challenges such as complex manufacturing processes and high costs, the market is buoyed by increasing demand for effective treatments for genetic disorders and other diseases. As technology continues to advance and collaborations between industry stakeholders intensify, the viral vector manufacturing market will play a crucial role in shaping the future of modern medicine.
Inquire Before Buying:
0 notes
123567-9qaaq9 · 6 months ago
Text
Detailed Report on Upstream Bioprocessing Market  | BIS Research 
Upstream Bioprocessing refers to the initial phase of Biopharmaceutical production that involves the preparation and growth of cells or microorganisms to produce the desired biological product. 
The Global Upstream Bioprocessing Market was valued at $250.1 million in 2023 and is expected to reach $1,639.1 million by 2033, growing at a CAGR of 20.68% between 2023 and 2033.
Upstream Bioprocessing Overview 
Upstream Bioprocessing is an advanced manufacturing approach used in the production of biological products, including pharmaceuticals, biopharmaceuticals, and industrial enzymes. This method is characterized by the uninterrupted flow of materials through the production process, from the initial cultivation of cells or microorganisms to the final product purification.
Grab the free sample page click here 
Key Stages involved in Upstream Bioprocessing 
Cell Line Development 
Media Preparation 
Bioreactor Cultivator 
Monitoring and Control
Key Applications for Upstream Bioprocessing 
Biopharmaceutical Production 
Monoclonal Antibodies 
Recombinant Proteins 
Vaccines 
Gene Therapy- Production of viral vectors (such as lentivirus and adenovirus) for delivering genetic material in gene therapy applications.
Cell Therapy - Cultivation of stem cells and other cell types used in regenerative medicine to repair or replace damaged tissues and organs.
Agricultural Biotechnology - Development of genetically modified organisms (GMOs) and biofertilizers to enhance crop yield, pest resistance, and nutrient utilization.
Market Drivers for Upstream Bioprocessing Market  
Growing demand for Biopharmaceuticals 
Advancements in Biotechnology 
Expansion of Personalized Medicines 
Technological Innovations 
Environmental Sustainability 
These market drivers collectively contribute to the growing adoption and expansion of the Upstream Bioprocessing Market
Recent Developments in the Upstream Bioprocessing Market
• Waters and Sartorius expanded their partnership to develop integrated analytical tools for downstream biomanufacturing following their successful collaboration in upstream processes. •  Sartorius and Repligen Corporation launched an integrated system with Biostat STR and XCell ATF for upstream process intensification.
Visit our Life Sciences and Biopharma Vertical page for better understanding 
Key Players in the market 
•   3M •   Bio-Rad Laboratories, Inc. •   Thermo Fisher Scientific, Inc. •   Merck KGaA •   Sartorius AG •   Danaher Corporation
Key Questions Answered
Q What is the estimated global market size for the Upstream Bioprocessing Market ?
Q What future trends are expected in the Upstream Bioprocessing Market ?
Q  What does the supply chain of the Upstream Bioprocessing Market  look like?
QWhat does the value chain of the Upstream Bioprocessing Market  look like?
Q  What is the regulatory framework within the Upstream Bioprocessing Market ?
Q  What is the patent analysis trend based on country and year in the Upstream Bioprocessing Market ?
Q  How has the COVID-19 outbreak affected the future trajectory of the Upstream Bioprocessing Market ?
Q What are the next frontiers in the Upstream Bioprocessing Market ?
Conclusion
Upstream bioprocessing is a critical and foundational phase in the production of biopharmaceuticals, playing a vital role in the cultivation and optimization of cells or microorganisms to produce high-quality biological products.
As the biopharmaceutical industry continues to evolve, upstream bioprocessing will remain a cornerstone, driving the development of new and innovative therapies that improve patient outcomes and address unmet medical needs.
0 notes
samutdbmr · 9 months ago
Text
0 notes
priyanshisingh · 1 year ago
Text
Molecular Biology Enzymes Kits and Reagents Market Size, A Forecasted Outlook for 2023-2030
The latest market report published by Credence Research, Inc. “Global Molecular Biology Enzymes Kits and Reagents Market: Growth, Future Prospects, and Competitive Analysis, 2022 – 2030. The global demand for molecular biology enzymes kits and reagents market was valued at USD 20.2 Billion in 2022 and is expected to reach USD 38.12854245 Billion in 2030, growing at a CAGR of 9.50% between 2023 and 2030.
Molecular Biology Enzymes Kits and Reagents Market encompasses an extensive range of products crucial for various molecular biology protocols, research, and clinical applications. This market segment includes enzymes such as DNA and RNA polymerases, reverse transcriptases, restriction endonucleases, ligases, and various modifying enzymes, among others. These enzymes play pivotal roles in procedures like PCR, qPCR, sequencing, cloning, cDNA synthesis, and restriction digestion. Accompanying these enzymes are specialized reagents and kits optimized for specific applications, ensuring accuracy, reproducibility, and high yield. The demand in this market has been amplified due to the burgeoning biotechnology and pharmaceutical sectors, ongoing research in genetics and molecular biology, and the rising prevalence of infectious diseases and genetic disorders.
Additionally, the recent surge in genomic studies and personalized medicine has further propelled the requirement for high-quality enzymes and associated reagents. Major players in this space are continuously investing in R&D to offer innovative, efficient, and cost-effective solutions. However, the market's growth can be constrained by factors like high costs of certain products and stringent regulatory landscapes. Overall, the Molecular Biology Enzymes Kits and Reagents Market represents a dynamic and vital segment in the life sciences industry, with its products underpinning many modern biological and clinical breakthroughs.
Molecular Biology Enzymes Kits and Reagents Market Key Growth Trends have been a subject of great interest and significance in the scientific community. These trends highlight the constant evolution and advancements in molecular biology research, particularly in relation to enzymes, kits, and reagents. Researchers are continually seeking innovative solutions to optimize experimental procedures and improve efficiency. The market offers a wide range of enzymatic products that cater to diverse applications such as DNA amplification, sequencing, cloning, gene expression analysis, and protein purification. These growth trends indicate an increasing demand for user-friendly enzyme kits that provide reliable results with minimal effort. Furthermore, there is a growing emphasis on environmentally friendly products that reduce waste generation while maintaining high performance standards.
Molecular Biology Enzymes Kits and Reagents Market Key Offerings-
1. Enzymes
DNA Polymerases: Essential for PCR, qPCR, and sequencing applications.
RNA Polymerases: Used for in vitro transcription processes.
Reverse Transcriptases: Central to cDNA synthesis and RT-PCR.
Restriction Endonucleases: Enable DNA fragment analysis and cloning.
Ligases: Vital for linking DNA fragments together.
Modifying Enzymes: Such as methyltransferases and phosphatases, crucial for modifying DNA molecules.
2. Kits
PCR and qPCR Kits: Contain all necessary reagents for amplifying DNA or RNA.
cDNA Synthesis Kits: Offer reagents for synthesizing complementary DNA from RNA templates.
DNA Sequencing Kits: Provide the necessary components for DNA sequencing procedures.
Cloning Kits: Simplify the process of inserting DNA into vectors for expression or analysis.
Genotyping Kits: Facilitate the identification of genetic variations.
3. Reagents
Nucleotides: Basic building blocks for DNA and RNA synthesis.
Primers and Probes: Short strands of nucleic acids essential for processes like PCR.
Buffers and Solutions: Maintain optimal conditions for enzymatic reactions.
Dyes and Stains: Enable visualization of nucleic acids.
4. Sample Preparation Products
DNA and RNA Extraction and Purification Kits: Help in isolating nucleic acids from various samples.
Gel Extraction Kits: Allow for the purification of DNA fragments from agarose gels.
5. Assay Kits
Gene Expression Assays: Facilitate the study of gene activity.
Mutation Detection Assays: Enable the identification of genetic mutations.
Methylated DNA Detection Kits: Used to study DNA methylation patterns.
6. Library Preparation Kits
Essential for next-generation sequencing, these kits provide tools to create libraries from DNA or RNA samples for sequencing applications.
7. Accessory Products
Positive Controls: Provide known references for various assays.
Stabilizers and Preservatives: Extend the shelf-life of enzymes and other sensitive products.
Browse 250 pages report Molecular Biology Enzymes Kits and Reagents Market By Product (Kits & Reagents, Enzymes, Ligases, Restriction Endonucleases, Reverse Transcriptases, Other Enzymes) By Applications (PCR, Sequencing, Cloning, Epigenetics, Restriction Digestion, Synthetic Biology, Other) - Growth, Future Prospects & Competitive Analysis, 2016 – 2030)- https://www.credenceresearch.com/report/molecular-biology-enzymes-kits-and-reagents-market
Molecular Biology Enzymes Kits and Reagents Market Regional Analysis-
1. North America:
Status: Dominates the global market in terms of revenue.
Drivers: Robust biotechnological and pharmaceutical sectors, extensive R&D activities, advanced healthcare infrastructure, and the presence of key market players.
Key Countries: The United States, owing to its heavy investments in biopharmaceutical research and genomics, is a significant contributor.
2. Europe:
Status: Second-largest market after North America.
Drivers: Strong academic and research base, especially in countries like Germany and the UK, paired with substantial public and private funding.
Key Countries: Germany, UK, France, and Switzerland, with their rich history in pharmaceuticals and biotechnology research.
3. Asia-Pacific (APAC):
Status: Fastest-growing region in the market.
Drivers: Rapidly developing biotechnology sectors in countries like China and India, coupled with increasing government funding in healthcare and research. The region's large population also drives clinical research and diagnostics, necessitating molecular biology products.
Key Countries: China, India, Japan, and South Korea.
4. Latin America:
Status: Moderate growth compared to other regions.
Drivers: Gradual growth in biotechnology and healthcare sectors, increasing public awareness, and rising government investments in research.
Key Countries: Brazil and Mexico are the leading contributors due to their sizable pharmaceutical and biotech industries.
5. Middle East & Africa (MEA):
Status: Smaller market share but shows potential for growth.
Drivers: Increasing investments in healthcare and research, especially in affluent nations like the UAE and Saudi Arabia.
Key Countries: South Africa, UAE, and Saudi Arabia. South Africa, in particular, has shown significant strides in healthcare research.
Molecular Biology Enzymes Kits and Reagents Market Future Outlook-
The future of the Molecular Biology Enzymes Kits and Reagents Market is anticipated to be vibrant and dynamic, underpinned by a series of technological breakthroughs and evolving healthcare paradigms. As the world increasingly leans towards personalized medicine, the demand for molecular tools that facilitate precise genetic and genomic analyses is expected to surge. Additionally, the rising prevalence of chronic diseases and global health crises, such as pandemics, further emphasize the importance of molecular diagnostics and research, consequently bolstering the market. Technological advancements, especially in areas like next-generation sequencing, CRISPR-Cas genome editing, and single-cell analysis, will likely shape the market's landscape, opening new avenues for diagnostics and therapeutic interventions.
Moreover, emerging economies are set to play a pivotal role, with their escalating healthcare investments and burgeoning biotech sectors. However, the market isn't without challenges. Regulatory complexities, high costs of advanced solutions, and ethical considerations in areas like gene editing will require navigation. Collaborations, innovations, and strategic mergers will be key for market players to thrive. In essence, the Molecular Biology Enzymes Kits and Reagents Market is on the precipice of significant growth, poised to make monumental contributions to science and medicine.
Why to Buy This Report-
The report provides a qualitative as well as quantitative analysis of the global Molecular Biology Enzymes Kits and Reagents Market  by segments, current trends, drivers, restraints, opportunities, challenges, and market dynamics with the historical period from 2016-2020, the base year- 2021, and the projection period 2022-2028.
The report includes information on the competitive landscape, such as how the market's top competitors operate at the global, regional, and country levels.
Major nations in each region with their import/export statistics
The global Molecular Biology Enzymes Kits and Reagents Market  report also includes the analysis of the market at a global, regional, and country-level along with key market trends, major players analysis, market growth strategies, and key application areas.
Browse Full Report: https://www.credenceresearch.com/report/molecular-biology-enzymes-kits-and-reagents-market
Visit: https://www.credenceresearch.com/
Related Report: https://www.credenceresearch.com/report/cannabinoid-biosynthesis-market
Related Report: https://www.credenceresearch.com/report/oncology-molecular-diagnostics-market
Browse Our Blog: https://www.linkedin.com/pulse/molecular-biology-enzymes-kits-reagents-market-share-demand-singh
About Us -
Credence Research is a viable intelligence and market research platform that provides quantitative B2B research to more than 10,000 clients worldwide and is built on the Give principle. The company is a market research and consulting firm serving governments, non-legislative associations, non-profit organizations, and various organizations worldwide. We help our clients improve their execution in a lasting way and understand their most imperative objectives. For nearly a century, we’ve built a company well-prepared for this task.
Contact Us:
Office No 3 Second Floor, Abhilasha Bhawan, Pinto Park, Gwalior [M.P] 474005 India
0 notes
impossibledeanmakerwombat · 2 years ago
Text
Protein Expression Technology Market : Worldwide Industry Analysis and New Market Opportunities Explored By 2022 to 2029
Protein Expression Technology Market alludes to the technique in which proteins are incorporated, adjusted and managed in living beings. The innovation associated with the procedure incorporates utilization of articulation vectors, reagents and competent cells. From 2022 to 2029, the global market for protein expression technology is anticipated to increase significantly at a 7.3% CAGR, with a market value of about US$ 2.4 Billion in 2022.
In 2021, the global market for protein expression technology is expected to be dominated by Mammalian Expression Systems, with a share of about 38.2%.
Drug discovery, clinical research, and diagnostics are all undergoing radical changes as a result of the high impact of developing technologies like proteomics. End users in the life sciences sector are therefore seeking comprehensive integrated solutions.
Request to View Sample Copy of Report @ https://www.futuremarketinsights.com/reports/sample/rep-gb-1540
According to this extensive research, the global protein expression market is expected to grow at a robust CAGR of 7.7% and reach a market size of more than US$ 3 Bn by the end of 2027 from a value of around US$ 1,700 Mn in 2017. The estimates are based on a systematic primary and secondary research, considering the major drivers, restraints that are limiting the market and also the trends following the global protein expression technology market.
Global Protein Expression Technology Market: Dynamics
The growth of global protein technology market is contributed mostly by the advancements in technology. It is also accompanied by many other factors that are helping in the expansion of market. The major drivers are enhanced sales network and distribution channels, increasing demand in proteomics and biologics and growing demand for therapeutic antibody research. However, there are also a few factors that are limiting the growth of global protein expression technology market like in-house development of expression systems, high cost associated with expression vectors and other reagents, complex workflow and also low protein production which has the maximum restraining force.
Request to View TOC @ https://www.futuremarketinsights.com/toc/rep-gb-1540
Key Market Segments Covered In Protein Expression Technology Market Research
By Expression System :
Insect Cell Expression System
Prokaryotic Expression System
Mammalian Expression System
Yeast Expression System
Other
By Product :
Expression Vectors
Reagents
Competent Cells
Instruments
By Application :
Drug Discovery
Protein Purification
Protein Therapeutics
Diseases Diagnostic & Monitoring
By End User :
Biotechnology Companies
Pharmaceutical Companies
Contract Research Organisation
Academic Research Institute
Full Report @https://www.futuremarketinsights.com/reports/protein-expression-technology-market
0 notes
my-123 · 3 years ago
Text
Protein Expression Technology Market 2022 Development Status, Competition Analysis, Type and Application 2029
The global Protein Expression Technology Market is projected to experience significant growth during the forecast period, due to the growing demand for proteomics for the identification of several proteins that help in drug discovery, diseases diagnosis, and development of target-specific drugs.
The global protein expression technology market was valued US$ 2.3 Bn in 2021, and is expected to increase at a CAGR of 7.3% during the forecast period of 2022-2029. There is growing demand for protein expression technology in multiple industries for numerous applications such as biologics production, therapeutic protein production, and research application.
Strategic Partnerships to Lend Winning Imperatives for Market Participants
The key players are focusing on collaborations, territorial expansion, mergers, and acquisitions to increase their share in the global protein expression technology market space. Mergers and acquisitions help them expand their existing product portfolio and topographical reach.
For example, to strengthen its life science business, Thermo Fisher Scientific Inc. acquired Life Technologies Corporation, which incorporates cutting-edge proteomics and genomics innovations. Increasing regulatory approvals for biologics and technological advancements have prompted high demand for innovative products.
More Valuable Insights on Protein Expression Technology Market
Future Market Insights brings a comprehensive research report on forecasted revenue growth at global, regional, and country levels, and provides an analysis of the latest industry trends in each of the sub-segments from 2015 to 2029. The global protein expression technology market is segmented in detail to cover every aspect of the market, and present a complete market intelligence approach to the reader.
The study provides compelling insights on the protein expression technology market on the basis of expression system (insect cell expression systems, prokaryotic expression systems, mammalian expression systems, and yeast expression systems), product type (expression vectors, reagents, competent cells, and instruments), application (drug discovery, protein purification, protein therapeutics, and diseases diagnostic & monitoring), and end user (biotechnology companies, pharmaceutical companies, contract research organizations, and academic research institutes), across seven major regions.
Get More Information: https://www.futuremarketinsights.com/reports/protein-expression-technology-market
0 notes
crediblemarketblogs · 3 years ago
Text
Cross Flow Filtration Systems Market Size 2022 Industry Insights by Global Share, Top Key Players, COVID-19 Impact, Regional Analysis and Forecasts to 2030
Global Cross Flow Filtration Systems  Market Development Strategy Pre and Post COVID-19, by Corporate Strategy Analysis, Landscape, Type, Application, and Leading 20 Countries covers and analyses the potential of the global Cross Flow Filtration Systems  industry, providing statistical information about market dynamics, growth factors, major challenges, PEST analysis and market entry strategy Analysis, opportunities and forecasts. The biggest highlight of the report is to provide companies in the industry with a strategic analysis of the impact of COVID-19.
DOWNLOAD FREE SAMPLE REPORT@ https://crediblemarkets.com/sample-request/cross-flow-filtration-systems-market-169357
Cross Flow Filtration Systems Market: By Type
Single-use Systems Reusable Systems
Cross Flow Filtration Systems Market: By Applications
Bioprocessing Food & Beverage Viral Vectors and Vaccine Purification Pharmaceutical Water Production Others
Cross Flow Filtration Systems Market: Key Players
Alfa Laval AB TAMI Industries GE Healthcare Ater-Tek Veolia Graver Technologies Spectrum Laboratories EMD Milipore Novasep Parker Hannifin Corp. Evoqua Water Technologies Applied Membrane Tech Sartorius Stedim Biotech S.A. GEA Group Siemens Water Technologies Danaher Corporation Koch Membrane Systems The Dow Chemical Company Merck Millipore OSMO Membrane systems TangenX Technology Corporation
Key benefits for industry players and stakeholders:
 ·         Industry drivers, constraints and opportunities covered by the study
·         Neutral view on market performance
·         Current industry trends and developments
·         Competitive environment and strategies of the main players
·         Covering potential and niche segments and regions with promising growth
·         Historical, current and forecast market size in terms of value
·         In-depth Analysis of the Fixed Endoscope Market
  Direct Buy This Report now@ https://crediblemarkets.com/reports/purchase/cross-flow-filtration-systems-market-169357?utf8=%E2%9C%93&license_type=single_user
 Reasons to Buy This Report
• Qualitative and quantitative market analysis based on segmentation, including economic and non-economic factors
• Provide market value data for each segment and sub-segment
• Shows the regions and segments that are expected to grow the fastest and dominate the market
• Geographic analysis that highlights the consumption of products/services in the region and reveals the factors affecting the market in each region
• Competitive landscape that includes market rankings of major players along with new service/product launches, partnerships, business expansions and acquisitions in the last five years from leading companies
• Comprehensive company profile, including company overview, company insights, product benchmarking and SWOT analysis for key market players
Table of Content
Table of Content
1 Cross Flow Filtration Systems Market - Research Scope
1.1 Study Goals
1.2 Market Definition and Scope
1.3 Key Market Segments
1.4 Study and Forecasting Years
2 Cross Flow Filtration Systems Market - Research Methodology
2.1 Methodology
2.2 Research Data Source
2.2.1 Secondary Data
2.2.2 Primary Data
2.2.3 Market Size Estimation
2.2.4 Legal Disclaimer
3 Cross Flow Filtration Systems Market Forces
3.1 Global Cross Flow Filtration Systems  Market Size
3.2 Top Impacting Factors (PESTEL Analysis)
3.2.1 Political Factors
3.2.2 Economic Factors
3.2.3 Social Factors
3.2.4 Technological Factors
3.2.5 Environmental Factors
3.2.6 Legal Factors
3.3 Industry Trend Analysis
3.4 Industry Trends Under COVID-19
3.4.1 Risk Assessment on COVID-19
3.4.2 Assessment of the Overall Impact of COVID-19 on the Industry
3.4.3 Pre COVID-19 and Post COVID-19 Market Scenario
3.5 Industry Risk Assessment
4 Cross Flow Filtration Systems  Market - By Geography
Contact Us:
Credible Markets
99 Wall Street 2124 New York, NY 10005
Email- 
0 notes
marketresearchstrategy · 3 years ago
Text
Tangential Flow Filtration Market Share, Industry Growth, Trend, Drivers, Challenges, Key Companies by 2028
The Global Tangential Flow Filtration Market research report published by Reports and Data offers a comprehensive evaluation of the Tangential Flow Filtration market on the global scale and sheds light on the growth opportunities, prospects, and enables the readers to formulate strategic plans. The report also provides insightful data about the market capacities, technological advancements, R&D developments, and other key features influencing market growth. The report offers an in-depth analysis of the value chain, upstream and downstream factors, sales network and distribution channels, growth trends, driving and restraining factors, developments, production and consumption pattern, end-users, and regional segmentation. The report also offers relevant and useful information to help the new entrants and established companies strengthen their market position.
Get a sample of the report @ https://www.reportsanddata.com/sample-enquiry-form/4550
The report provides extensive coverage of the supply chain, key players of the industry, consumer base, company profiles, production and consumption rate, primary applications, and other relevant data. It provides an in-depth assessment of the key companies operating in the market along with their company profiles, business overview, production and manufacturing capacity, product portfolio, financial standing, global position, and business expansion plans. It also studies recent mergers and acquisitions, joint ventures, product launches, partnerships, collaborations, and agreements among other. The report also provides insights into new entrants and their strategic alliances to gain a robust footing in the market.
Key Manufacturers in the Global Tangential Flow Filtration Market:
Danaher Corporation
Merck Millipore
Sartorius Stedim Biotech S.A.
Parker Hannifin Corporation
GE Healthcare
Alfa Laval AB
Koch Membrane Systems, Inc.
Novasep
Pendotech
Spectrum Laboratories, Inc.
Request a discount on the report @ https://www.reportsanddata.com/discount-enquiry-form/4550
The report also provides an extensive regional segmentation to offer the readers key insights into the spread of the market over key geographical regions. It covers production and consumption patterns, import/export, supply and demand, consumer demand and behavior, key trends, and presence of key players in each region. The report also offer a country-wise analysis to impart a better understanding of the revenue growth of the market in each region.
North America (U.S., Canada, Mexico)
Europe (U.K., Italy, Germany, France, Rest of Europe)
Asia Pacific (India, Japan, China, South Korea, Australia, Rest of APAC)
Latin America (Chile, Brazil, Argentina, Rest of Latin America)
Middle East & Africa (Saudi Arabia, U.A.E., South Africa, Rest of MEA)
Product Type Outlook (Revenue, USD Billion; 2018-2028)
TFF System
Membrane Filter
Others
Technique Type Outlook (Revenue, USD Billion; 2018-2028)
Ultrafiltration
Microfiltration
Others
Material Type Outlook (Revenue, USD Billion; 2018-2028)
PES/PE Membrane
Regenerated Cellulose
Others
Application Outlook (Revenue, USD Billion; 2018-2028)
Bioprocess
Viral Vector Purification
Others
End-Use Outlook (Revenue, USD Billion; 2018-2028)
Pharmaceutical and Biotechnological Companies
Academic & Research Institutes
Contract Research Organizations
To know more about the report @ https://www.reportsanddata.com/report-detail/tangential-flow-filtration-market
Key Questions Addressed in the Report:
What is the market size the global Tangential Flow Filtration market is expected to reach over the forecast period? What is the expected CAGR?
What are the key segments of the market?
What are the key products and applications of the Tangential Flow Filtration market?
What factors are expected to drive and restrain market growth over the forecast period?
What are the key outcomes of SWOT analysis and Porter’s Five Forces analysis?
Request a customization of the report @ https://www.reportsanddata.com/request-customization-form/4550
Thank you for reading our report. The report can be customized based on regional segmentation and competitive landscape. Kindly get in touch with us to know more and our team will ensure the report is well suited to meet your requirements.
Browse more related reports:
Electronic Clinical Outcome Assessment (eCOA) Solution Market: https://www.biospace.com/article/electronic-clinical-outcome-assessment-ecoa-solution-market-to-reach-usd-3-48-billion-by-2028/
Aminoglycosides Market: https://www.biospace.com/article/aminoglycosides-market-size-to-reach-usd-2-16-billion-by-2028-reports-and-data/
Insulin Pens Market: https://www.biospace.com/article/insulin-pens-market-size-to-reach-usd-46-43-billion-in-2028-reports-and-data/
Cancer Diagnostics Market: https://www.biospace.com/article/cancer-diagnostics-market-to-reach-usd-252-22-billion-by-2027-reports-and-data/
Emergency Ventilator Market: https://www.biospace.com/article/emergency-ventilator-market-size-to-reach-usd-1-616-13-million-in-2028-reports-and-data/
0 notes
market-insights-dbmr · 3 years ago
Link
0 notes
colinwilson11 · 2 months ago
Text
Tumblr media
The vector purification market involves the purification of gene delivery vectors including adeno-associated viruses (AAVs), lentiviruses, retroviruses and others. Vector purification is a critical step in developing gene therapies and cell therapies to ensure safety and efficacy. It removes any contaminants and preferential selection of high titer and low defective vector particles. The growing pipeline of gene therapy and cell therapy products and increasing approvals has augmented the demand for vector purification systems and kits.
0 notes
amitshinde7793 · 3 years ago
Link
0 notes
123567-9qaaq9 · 7 months ago
Text
Protein Expression Market Outlines, Future Trends, Insight And Quality Analysis 
Tumblr media
Protein Expression is a powerful technique used to produce proteins in large quantities by introducing the gene encoding the protein of interest into a host organism, typically bacteria, yeast, insect cells, or mammalian cells
The Recombinant Protein Expression  was valued at $2,393.0 million in 2023 and is expected to reach $6,963.6 million by 2033, growing at a CAGR of 11.27% between 2023 and 2033
Gene Expression Analysis Overview 
Selection of Expression System: The choice of expression system depends on factors such as the size and complexity of the protein, desired post-translational modifications, and downstream applications. 
Common expression systems include bacterial (e.g., Escherichia coli), yeast (e.g., Saccharomyces cerevisiae), insect cells (e.g., Sf9 cells), and mammalian cells (e.g., Chinese hamster ovary cells).
Cloning of the Gene: The gene encoding the protein of interest is isolated and cloned into an expression vector. The vector contains regulatory elements such as promoters and enhancers that drive gene expression in the host organism.
Transformation or Transfection: The recombinant expression vector is introduced into the host organism by transformation (in bacteria and yeast) or transfection (in insect cells and mammalian cells). 
Protein Production: The host cells are cultured under optimized conditions to produce the recombinant protein.
Protein Purification: After protein expression, the recombinant protein is purified from the host cell lysate or culture supernatant. 
Market Segmentation
Segmentation 1: By Application
Segmentation 2: By End User 
Segmentation 3: By Product
Segmentation 4: By Expression System
Segmentation 5: By Region
Protein expression in North America is a dynamic and crucial field with a significant impact across industries. 
The region, especially North America, is a global leader in biopharmaceuticals, relying extensively on protein expression for producing biologics, including monoclonal antibodies and vaccines. 
North America holds the largest share of the protein expression market
Download our sample page now click here !
Application for  Recombinant Protein Expression Market 
Drug Discovery 
Structural Biology 
Disease Modelling 
Enzyme Production 
Vaccines Development 
Therapeutic Proteins 
Immunoassays 
Key Market Players 
Agilent Technologies, Inc.
Bio-Rad Laboratories, Inc.
Charles River Laboratories International, Inc.
Danaher Corporation (Abcam plc.)
GenCefe Co., Ltd.
Genscript Biotech Corporation
And many others 
Market Dynamics
Market Drivers 
Increasing Demand for Protein Biologics Creating the Need for Protein Expression 
Market Restraints 
Long and Complicated Regulatory Timelines and Approvals of Recombinant Proteins and Biologics
Market Opportunities 
Rising Awareness of Proteomics in Emerging Countries 
 Visit our Life Sciences & Biopharma page for better understanding 
Key factors contributing to the growth of the recombinant protein expression market 
Expanding applications of recombinant proteins in drug discovery, biomanufacturing, and diagnostic assays
Rising prevalence of chronic diseases and the need for innovative therapies.
Recent Developments in the Recombinant Protein Expression Market
In January 2024, Evosep, a leader in sample preparation for mass spectrometry-based proteomics, partnered with Thermo Fisher Scientific Inc., a global scientific leader, to advance clinical proteomics research. This collaboration would combine Evosep's sample separation technology with Thermo Fisher Scientific Inc.'s mass spectrometry instruments, enhancing proteomics research capabilities.release would support pharmaceutical and biotechnology companies engaged in the manufacturing of therapeutic proteins, with the goal of improving product quality and expediting time-to-market.
Key Questions Answered 
Q What is the estimated global market size for the protein expression market?
Q What are the future trends expected in the protein expression market?
Q What does the supply chain and value chain of the protein expression market look like?
Q  What is the regulatory framework of the protein expression market?
Q How has the COVID-19 outbreak affected the future trajectory of the protein expression market?
Q What are the market entry barriers and opportunities in the protein expression market?
Q What are the major market drivers, challenges, and opportunities of the protein expression market?
Q How is each segment of the protein expression market expected to grow during the forecast period, and what is the anticipated revenue generated by each of the segments by the end of 2033?
Q What is the growth potential of the global protein expression market in North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World, and what are the driving and challenging factors of the market in each of these regions?
Q Who are the leading players with significant offerings in the protein expression market, and what is the current market dominance for each of these leading players? Who are the next frontiers in the protein expression market?
Conclusion 
In conclusion, theProtein expression market continues to thrive and evolve as a vital component of numerous industries, including biotechnology, pharmaceuticals, agriculture, and research
0 notes
samutdbmr · 10 months ago
Text
0 notes
mikedbmr · 3 years ago
Text
IV Equipment Market Business Outlook with COVID-19 Scenario and Forecast To 2026
Latest research report, titled “IV Equipment Market Insights 2021 and Forecast 2026, This includes overview and deep study of factors which are considered to have greater influence over future course of the market such as market size, market share, different dynamics of the industry, IV Equipment market companies, regional analysis of the domestic markets, value chain analysis, consumption, demand, key application areas and more. The study also talks about crucial pockets of the industry such as products or services offered, downstream fields, end using customers, historic data figures regarding revenue and sales, market context and more.
New Players in the market are facing tough competition from established international Players as they struggle with technological innovations, reliability and quality issues. The report will answer questions about the current market developments and the scope of competition, opportunity cost and more.
Have a fresh look with latest Trend and Outlook@ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-iv-equipment-market
This report investigates the IV Equipment industry by examining the industry chain, policies, and plans, as well as products, manufacturing chains, cost structures, and other market factors. The report looks at the regional market for IV Equipment market in addition to product types. It investigates product prices and revenues, supply and demand logistics, production capacity and utilization efficiency, and industry growth rates across the globe.
Tumblr media
This market report comprises of possible revenue growth, potential lucrative opportunities, product ranges, pricing factors, and parameters to confer the emerging and new entrants in the industry with a structured market data. Moreover, it includes the recent business agreements, mergers, acquisitions, partnerships, and even fallouts to provide the industry players with complete overview of the IV Equipment Market. Some of the key manufacturers operating in this market include: BD, Ascor SA, Moog Inc., Smiths Group plc, B. Braun Melsungen AG, AngioDynamics, Terumo Corporation, ICU Medical, Inc., Fresenius SE & Co. KGaA.
Key Highlights of the IV Equipment Market:
A complete Industry Analysis and assessment of parent market.
Historical, current, and projected size of the IV Equipment market from the standpoint of both value and volume.
Reporting and evaluation of recent industry developments in the IV Equipment market.
It involves analysis of segments of Market Product and regional analysis.
Thorough profiling and examination of the key market players and their strategies.
It includes Covid-19 Impact Analysis of IV Equipment market.
Market Drivers
The chronic diseases incidences have increases which has driven the market growth
The rise in the obese and elderly population is boosting the market growth
The ambulatory infusion pumps has risen due to surging home care market
Needlestick injuries and infections have increased which has led the market growth
Market Restraints
The medication errors driven from infusion pumps leading to product recalls is hampering the market growth
The high cost associated in the treatment as well as risk associated with the procedure act as a restrain to the market
Get Sample Report + All Related Graphs & Charts @ https://www.databridgemarketresearch.com/toc/?dbmr=global-iv-equipment-market
Table of Content (TOC):
Chapter 1: Introduction and Overview
Chapter 2: Industry Cost Structure and Economic Impact
Chapter 3: Rising Trends and New Technologies with Major key players
Chapter 4: Global IV Equipment Market Analysis, Trends, Growth Factor
Chapter 5: IV Equipment Market Application and Business with Potential Analysis
Chapter 6: IV Equipment Market Segment, Type, Application
Chapter 7: IV Equipment Market Analysis (by Application, Type, End User)
Chapter 8: Major Key Vendors Analysis of IV Equipment Market
Chapter 9: Development Trend of Analysis
Chapter 10: Conclusion
Some of the key questions answered in the report include:
What is the overall structure of the market?
What was the historical value and what is the forecasted value of the market?
What are the key product level trends in the market?
What are the market level trends in the market?
Which of the market players are leading and what are their key differential strategies to retain their stronghold?
Which are the most lucrative regions in the market space?
To get crucial insights of the market, visit@ https://www.databridgemarketresearch.com/reports/global-iv-equipment-market
About Us:
Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market
Contact:
Data Bridge Market Research
Tel: +1-888-387-2818
Browse Related Reports@
Rathke's Cleft Cyst Market
Viral Vector Purification Market
Johnson Neuroectodermal Syndrome Market
0 notes
digitalconvo · 4 years ago
Text
Viral Vector and Plasmid DNA Testing Services Market Detailed Analysis and Forecast 2019-2029
Global Viral Vector and Plasmid DNA Testing Services Market: Overview
The global viral vector and plasmid DNA testing services market is estimated to be influenced by the increased innovation and spending in research and development activities relating to the field. Viral vectors are those tools that are popular amongst molecular biologists and they make wide use of these tools to deliver genetic materials into cells. This same procedure can be conducted in cell culture (in vitro) or inside a living organism (in vivo). Viruses have developed into specialized molecular mechanisms in a bid to carry their genomes inside the cells that they infect. On the other hand, plasmids are small DNA molecules, which are separated physically from the chromosomal DNA and then they are able to replicate on their own. Abundantly found in bacteria as double-stranded, circular DNA molecules, these organisms are utilized widely in laboratories of biotechnology and genetic engineering. It is there where they are utilized for the purpose of amplifying and cloning or expressing certain types of genes.
The players in the global viral vector and plasmid DNA testing services market are increasingly focusing on the invention of new techniques in a bid to better the characterization of viral vectors is estimated drive the demand for the testing services over the period of analysis, from 2019 to 2029.
The global viral vector and plasmid DNA testing services market has been segmented based on testing services, end-user, and region. The main objective of providing such a comprehensive report is to provide a deep insight into the market.
Get Brochure of the Report @ https://www.tmrresearch.com/sample/sample?flag=B&rep_id=6587
Global Viral Vector and Plasmid DNA Testing Services market: Notable Developments
The global viral vector and plasmid DNA testing services market has witnessed some of the major developments in the last few years. One such significant development of the market is mentioned below:
In September 2019, Slovenia-based BIA Separations introduced CORNERSTONE AAV Process Development Service in the market. Following the launch of the service, the company also launched a purification technology called CIMasphere. This technology allows pulling out of host cell DNA and host cell protein before the process of manufacturing in an attempt to provide ultra-pure AAV products. This innovation is likely to assist the company to generate more revenue in the market.
Some of the key market players of the viral vector and plasmid DNA testing services market comprise the following
Charles River Laboratories International, Inc.
Advanced Bioscience Laboratories, Inc.
Cobra Biologics and Pharmaceutical Services
Lonza Group Ltd.
WuXi AppTec Group
Eurofins Scientific
Global Viral Vector and Plasmid DNA Testing Services Market: Growth Drivers
Inorganic Growth Strategies Likely to Shape Contours of the Market
Viral vectors are customized as per their requirements in certain specific applications but these vectors usually come with a few key characteristics, such as safety, low toxicity, stability, cell type specificity, and identification. These properties of viral vectors are likely to play an important role in supporting growth of the global viral vector and plasmid DNA testing services market. Viral vectors are seldom created from pathogenic viruses and they are altered in such a way that the risk of handling is minimized. Besides, viral vector causes no or minimal effect on the physiology of the infected cell.
A rise in the focus of market players on the development of innovative technologies in an attempt to improve the characterization of viral vectors is likely to encourage the development of the global viral vector and plasmid DNA testing services market in the years to come. A case in point is the development of Vac-Man 96 Vacuum Manifold by US-based Promega Corporation. This invention supports the processing of SV 96 plates for PCR product, genomic, and plasmid purification. The product finds utilization in Wizard SV 96 plasmid DNA purification system to isolate plasmid DNA.
To get Incredible Discounts on this Report, Click Here @https://www.tmrresearch.com/sample/sample?flag=D&rep_id=6587
Global Viral Vector and Plasmid DNA Testing Services Market: Regional Outlook
In the global viral vector and plasmid DNA testing services market, North America is likely to emerge as one of the prominent regions in the market. Such growth of the region is attributed to the various inorganic growth strategies taken by market players such as acquisitions, partnerships, and mergers. These strategies are taken to strengthen and widen the product portfolio of the market players present in the region. This factor is likely to boost the growth of North America in the years to come.
The global viral vector and plasmid DNA testing services market is segmented as:
Testing Services
Safety
Genetic Characterization
Purity
Identity
Potency
End User
Research Organizations
Pharmaceutical and Biotechnological Companies
Request For TOC @ https://www.tmrresearch.com/sample/sample?flag=T&rep_id=6587
About TMR Research:
TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in today’s supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients’ conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.
Contact:    
TMR Research, 3739 Balboa St # 1097, San Francisco, CA 94121 United States
Tel: +1-415-520-1050
0 notes