#Stage 3 Kidney Disease Be Reversed | Explore Tumblr posts and blogs

mcatmemoranda · 1 year ago

Text

SUMMARY AND RECOMMENDATIONS

●Triage – Among outpatients identified as having AKI, we refer to the emergency department those who have any of the following: Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 or 3 AKI (table 1); stage 1 AKI with an unclear etiology, or one that cannot be rapidly reversed with simple interventions, or in the presence of a concomitant, uncontrolled comorbid condition; or stage 1 AKI if the initial diagnostic evaluation and management cannot be performed in the outpatient setting. (See 'Identifying patients for emergency department referral' above.)

Those who are managed as an outpatient should be referred for outpatient nephrology consultation if the cause of AKI is not immediately apparent, if initial interventions fail to improve the kidney injury, if glomerulonephritis (GN) is strongly suspected, or when AKI occurs as a complication of treatment of an unrelated condition and future treatment depends upon nephrology input. (See 'Indications for urgent nephrology referral' above.)

●Indications for emergency kidney replacement therapy (KRT) – Emergency KRT should be performed in patients with AKI who have one or more of the following (see 'Evaluate need for urgent kidney replacement therapy' above):

•Hypervolemia with pulmonary edema that does not promptly respond to diuretics (see 'Hypervolemia with pulmonary edema' above)

•Severe hyperkalemia (serum potassium >6.5 mEq/L or those with symptoms or signs of hyperkalemia) (see 'Severe hyperkalemia' above)

•Life-threatening uremic symptoms, such as seizures or severe pericardial effusion (see 'Life-threatening uremic symptoms' above)

•Exposure to certain toxins (see 'Toxin exposure' above)

●Initial management

•Eliminate potential insults – Additional management entails elimination of potential insults, including hypotension, iodinated contrast agents, or medications such as nonsteroidal antiinflammatory drugs (NSAIDs), angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and nephrotoxins. (See 'Elimination and avoidance of potential insults' above.)

•Treat hypovolemic (if present) – Intravenous fluid therapy with 1 to 3 liters of crystalloid should be administered to patients with a clinical history consistent with fluid loss (such as vomiting and diarrhea), a physical examination consistent with hypovolemia (hypotension and tachycardia), or oliguria. However, fluid therapy should be avoided in patients with pulmonary edema or clear evidence of anuria. Additional fluid management depends upon the clinical condition and response to initial fluid therapy. (See 'Hypovolemic patients' above.)

Among patients with AKI and hypervolemia who are hemodynamically stable and not anuric, we start intravenous (IV) furosemide at 80 mg up to a single dose of 200 mg, or equivalent, to augment the urine output and relieve symptoms. Additional therapy depends upon the response to initial therapy. We typically initiate KRT for volume overload in patients who have anuria for more than 24 hours, who fail to respond to diuretics, or whose response to diuretics is insufficient to avoid worsening hypervolemia due to high obligate intake. (See 'Hypervolemic patients' above and 'Role of diuretics' above and 'Role of kidney replacement therapy' above.)

•Treat electrolyte imbalances (if present) – Electrolyte imbalances such as the following can complicate AKI and need specific management:

-Hyperkalemia (see 'Hyperkalemia' above)

-Hyperphosphatemia (see 'Hyperphosphatemia' above)

-Hypocalcemia (see 'Hypocalcemia' above)

-Hypomagnesemia and hypermagnesemia (see 'Hypomagnesemia and hypermagnesemia' above)

-Hyperuricemia (see 'Hyperuricemia' above)

•Treat metabolic acidosis (if present) – We initiate KRT in patients with oliguric or anuric AKI who are volume overloaded and have severe metabolic acidosis (a pH <7.1), unless the acidosis can be rapidly resolved by quickly correcting the underlying etiology (eg, diabetic ketoacidosis). However, in other patients who have no indications for acute KRT, bicarbonate may be administered instead of KRT to treat acidosis. Diuretics can be used in nonoliguric patients to prevent hypervolemia and to enhance excretion of acid. The goal serum bicarbonate level is 20 to 22 mEq/L and the goal pH is >7.2. Metabolic alkalosis with AKI is usually seen in volume depleted patients and responds to IV sodium chloride infusion. (See 'Managing acid-base disturbances' above.)

●Subsequent management

•Nutrition management – Patients with AKI generally benefit from dietary restrictions on potassium, phosphorous, sodium and fluid intake (1 to 1.5 L per day, except if volume depleted). Given the complexities of nutritional support in these patients and the individual needs of a given patient, we obtain a nutrition consult to best tailor therapy in hospitalized patients with severe stage 3 AKI. For patients with lesser stages of AKI, the need for consultation should be based upon an individual needs assessment. (See 'Managing nutrition' above.)

•Assess for uremia – We perform daily assessment of uremic signs and symptoms (such as anorexia, nausea, vomiting, metallic taste, altered mental status) to determine if KRT may be indicated. KRT initiation in such patients should be approached with a clear goal of monitoring whether or not putative uremic symptoms improve with therapy. Typically, several KRT sessions are required to determine if symptoms resolve with KRT. (See 'Assessing for uremia' above.)

•Assess for fluid and electrolyte imbalances – We monitor serum creatinine, electrolytes, albumin, and measures of fluid balance (weight, fluid intake, and urine output) daily in most patients, although more frequent monitoring may be warranted. (See 'Monitoring and follow-up' above.)

●Follow-up – We advise that patients hospitalized for moderate to severe AKI have an outpatient nephrology evaluation (or primary care if nephrology is unavailable) shortly after discharge. (See 'Monitoring and follow-up' above.)

#AKI

2 notes · View notes

beetrans · 2 years ago

Text

i'm Going Through It, pals

(cw pet illness & possible animal death & generally upsetting times)

tldr my best friend's dog is in critical care and prbably going to die if not immediately then likey in weeks and my best friend has been on the edge of full blown mental health crisis for some time and fully said if her dog dies she will have nothing to live for and kill herself and also I got a fantastic job but I cannot handle this.

my dearest friend (K) as a dog (T). T is 14 years old. T has been declining in wellbeing for the past two or three years, including losing vision, getting arthritis, and having liver and kidney function issues.

T lives with K's parents, while K does grad school on the other side of the country. K's parents went on vacation last Tuesday, and I (and my dog) have been at their house and dogsitting since the Sunday before (stayed with them for 3 days before they left).

T has been on a restricted vet diet (though parents gave her lots of table scraps as treats) and multiple medications. (She was actually due to have bloodwork a week from now.) This past Saturday, I noticed T was more lethargic, didn't want to leave her crate, wasn't eating, etc.; Sunday noticed a sore on her back, called K, cleaned it, scheduled a vet appointment for asap (ended up being Monday around noon). T wouldn't eat Sunday either, and didn't have her meds. (Got clearance from K and her sibling D (who then got clearance from parents) to do whatever needed to be done.)

At the vet, we did bloodwork, and found that T was both anemic and fully in kidney failure. Per the vet, the sore probably made her a bit worse (but likely resulted from the arthritis), and the not eating continued it, but she'd been in late stage kidney disease already and was only taking the vet diet for it; other meds were pain relief and liver function. T's legs were literally giving out under her as she tried to stand up.

we got her started on subQ fluids and anti nausea and sheared off more fur from the hot spot to keep it cleaner. got a referral to an emerg care clinic where they can sustain IV fluids for longer. had to leave her there until the other vet called back to confirm.

In this in-between time, I got a call from the longshot but very ideal job I'd interviewed for last week. Got the offer. Took it starting in two weeks. I'm still finishing grad school. Had to vent to an Unrelated friend because I felt on the edge of feeling like when I was on 24/7 suicide watch for a DIFFERENT friend back in undergrad.

K booked the soonest flight home. I made the beds back at parents' house. ate a drive through burger. Got a call back from vet. Drove there to pick up T and bring her to the other vet for more care.

D took the train in after work. I redirected them to come to the vet #2 bc I couldn't pick them up because I had to re-explain everything from the vet place #1 to #2.

At vet #2 I had to be told again that T might die before treatment can do anything, that treatment might do nothing at first, that treatment might only bring her back to Stage Four Plus Kidney Failure, that euthanasia might be the most humane option, and at K&D's direction still had to say go ahead w treatment.

D got to see T again, T at least looked behaviourally improved. Talked, went to bed. D picked up K from the airport in the morning, drove her to the vet to see T again, I got a call from the vet about her prognosis (no change), drove D to work. Drove back, tapped someone's Fancy Pickup Truck while reversing, man tried to pull me out of my (BORROWED.) car, had to report collision to resolve it, police agreed that there's really nothing damaged, won't file any insurance claim, but now gonna have to, idk, pay some asshole $200?? Anyways.

Got back "home", K isn't eating anything, lethargic, won't leave her parents' bedroom. Parents called (they're on a 12?hr time difference), suggested T be let to die, K hung up & started crying.

I have had lunch.

I skipped class yesterday, might have to do the same today, have to do class work, but also am just. In the childhood home of my dearest friend who I cannot comfort because her dearest friend who is her dog is going to die and the most I can do is help her redo her thesis for the third time because also her supervisor tried to get K to do something extremely unethical, we documented it, and now ethics is mad at her supervisor and K has an offer from a diff prof to join that lab instead but K cannot make any decisions rn.

So there we are.

#personal / pls don't rb this.#I'm just. on crisis alert mode and can't do anything more than I already am. and cannot escape this.#I have done just about the best someone could do in this situation and it also can only delay the inevitable.

5 notes · View notes

vishakharo · 4 days ago

Text

Why RO ZURIC Water Purifiers Are the Ultimate Choice for Clean and Healthy Water

In today’s fast-paced world, clean and healthy drinking water is a necessity, yet it is not always guaranteed. With rising concerns about water pollution, contaminants, and harmful substances found in municipal water supplies, investing in an efficient water purification system has become crucial. Among the many options available in the market, RO ZURIC water purifiers stand out as one of the top choices for ensuring clean, safe, and healthy drinking water. This article explores why RO ZURIC water purifiers are the ultimate choice for homes and offices, offering advanced filtration technology, unmatched performance, and health benefits.

1. State-of-the-Art Reverse Osmosis Technology

RO ZURIC water purifiers use Reverse Osmosis (RO) technology, one of the most effective methods of water purification. The RO process involves passing water through a semipermeable membrane that removes up to 99% of dissolved salts, bacteria, viruses, and other impurities. This multi-stage filtration system ensures that every drop of water is purified, leaving you with fresh, contaminant-free water. The RO technology is especially beneficial for treating hard water, removing harmful substances such as chlorine, fluoride, lead, pesticides, and even heavy metals like arsenic and mercury.

2. Advanced Filtration Stages for Maximum Purity

What makes RO ZURIC water purifiers stand out is their multi-stage filtration process, designed to tackle a wide variety of impurities that can be found in water. This system typically includes the following stages:

Sediment Filter: The first stage involves the removal of larger particles such as dirt, dust, and rust that might be present in the water supply. This step ensures that the subsequent filters are not clogged with debris.

Activated Carbon Filter: This stage removes chlorine, volatile organic compounds (VOCs), and unpleasant odors, improving the taste and smell of water. It also helps in reducing the risk of gastrointestinal issues caused by impurities.

Reverse Osmosis Membrane: The core of the filtration system, the RO membrane, effectively eliminates dissolved solids, heavy metals, bacteria, and viruses. This stage ensures that only pure, clean water passes through.

UV Sterilization: Many RO ZURIC 12 Liter Water purifiers are equipped with UV lamps to kill any remaining microorganisms that might have bypassed the other filters. This guarantees that the water is free from harmful bacteria and viruses, making it completely safe for consumption.

TDS Control: TDS (Total Dissolved Solids) control is an essential feature in RO ZURIC water purifiers. This helps maintain the ideal mineral content of the water, ensuring that it is not overly purified or stripped of essential minerals like calcium and magnesium, which are beneficial to health.

3. Health Benefits and Safety

The ultimate goal of any water purifier is to ensure the safety and health of its users, and RO ZURIC water purifiers excel in this area. Contaminated water can lead to numerous health issues, including stomach infections, waterborne diseases, and long-term exposure to harmful chemicals. RO ZURIC water purifiers address these concerns by removing a wide range of pollutants that can adversely affect health.

One of the most significant health benefits of RO ZURIC water purifiers is their ability to remove harmful microorganisms, such as bacteria, viruses, and protozoa, which can cause waterborne diseases. The UV sterilization feature ensures that even the most resistant pathogens are eradicated, making the water completely safe to drink. This is particularly crucial in regions where the quality of municipal water is questionable or when using water from natural sources like rivers or lakes.

Moreover, the removal of harmful chemicals like pesticides, chlorine, and heavy metals can significantly reduce the risk of chronic illnesses, including cancer and kidney diseases. RO ZURIC purifiers also help in reducing the hardness of water, which can cause issues such as skin irritation, dry hair, and the formation of limescale in appliances. Soft water is gentler on your skin and hair, promoting overall well-being.

4. User-Friendly and Convenient Design

RO ZURIC water purifiers are designed with user convenience in mind. They come with easy-to-use interfaces and space-saving designs that fit well into any modern kitchen or office setting. Many of these purifiers feature smart indicators that alert users when filters need to be replaced or when the water tank is full. Some models are equipped with touchscreens or digital displays that allow users to track the purification process, making them both functional and visually appealing.

Moreover, RO ZURIC water purifiers are equipped with auto shut-off features to conserve water and energy. Once the water tank is full, the system automatically switches off, preventing wastage. This makes them not only environmentally friendly but also cost-effective in the long run.

5. Long-Lasting Durability and Reliability

RO ZURIC water purifiers are built to last. These systems are made from high-quality materials and undergo strict quality control processes to ensure that they can withstand the test of time. The filters and membranes used in the purifier are designed for long-term use, with many models offering a filter life of up to 12 months before they need replacement. This long-lasting durability ensures that users get consistent performance and value for their money.

Furthermore, RO ZURIC water purifiers come with warranty periods and customer support services, giving users peace of mind in case of any issues. Whether it’s a technical fault or filter replacement, RO ZURIC’s reliable customer support ensures that your water purifier remains in optimal working condition.

6. Energy Efficient and Eco-Friendly

In today’s environmentally conscious world, energy efficiency is an essential consideration when choosing appliances. RO ZURIC water purifiers are designed to be energy-efficient, consuming less electricity compared to many traditional purification systems. The low power consumption of these purifiers makes them affordable to run, even in areas with frequent power outages.

Additionally, RO ZURIC purifiers are eco-friendly because they help reduce the need for bottled water. By providing an efficient solution for clean drinking water at home or in the office, these systems contribute to a reduction in plastic waste, promoting sustainability.

7. Cost-Effective in the Long Run

Although the initial cost of an RO ZURIC water purifier may be higher than traditional filtration systems, it is important to consider the long-term savings. The purifier eliminates the need for buying bottled water, which can add up significantly over time. Additionally, the low maintenance and durable design of RO ZURIC systems ensure that you won’t have to replace them frequently, making them a cost-effective choice in the long run.

8. Variety of Models to Choose From

RO ZURIC offers a wide range of water purifier models, each designed to meet the specific needs of different households or office environments. Whether you need a compact countertop model or a larger under-sink system, there is a purifier for every space. This variety ensures that users can find a model that fits both their budget and space requirements.

Conclusion

In conclusion, RO ZURIC water purifiers offer the ultimate solution for clean and healthy water. With their advanced filtration technology, multi-stage purification process, health benefits, and energy efficiency, they provide a level of purification that few systems can match. Whether you’re concerned about harmful chemicals, microorganisms, or the general quality of your drinking water, RO ZURIC purifiers ensure that every drop you drink is pure, safe, and refreshing. With their user-friendly design, long-lasting durability, and eco-friendly features, Let's achieve success together! Buy RO ZURIC water purifiers are undoubtedly a wise investment for anyone looking to ensure the health and safety of their family or workplace.

#ro water purifier #ro industry

0 notes

sidshospital · 9 months ago

Text

Renal Health: A Comprehensive Guide From The Best Kidney Specialist in Surat

The kidneys, two bean-shaped organs located on either side of the spine, play a crucial role in maintaining our overall health. Often overlooked, these vital organs are responsible for filtering waste and excess fluids from the blood, regulating blood pressure, and producing hormones that help control red blood cell production. In this comprehensive guide, we will delve into the intricacies of kidney health, understanding kidney disease, recognizing its symptoms, identifying risk factors, exploring types of kidney diseases, learning about kidney failure, and discussing preventive measures for chronic kidney disease.

What are Kidneys?

The kidneys are remarkable organs with multifaceted functions. They filter approximately 200 quarts of blood daily, producing about 1 to 2 quarts of urine, which helps eliminate waste and maintain the body’s fluid balance. Additionally, kidneys regulate electrolytes, acid-base balance, and blood pressure. Their role in red blood cell production and activation of vitamin D also contributes to overall health.

What is Kidney Disease?

Kidney disease, also known as renal disease, occurs when the kidneys’ functionality is impaired, leading to a reduced ability to filter waste and excess fluids. This condition can manifest in various forms and stages, ranging from mild to severe. Chronic kidney disease (CKD) is a common and progressive form that may develop over several years, often without noticeable symptoms in the early stages.

What are the Types of Kidney Disease?

Kidney diseases encompass a broad spectrum of conditions, each with its unique causes and characteristics. Our kidney specialists at SIDS Hospital, one of the best hospitals in Surat have shortlisted some common types of kidney diseases for your better understanding:

1. Chronic Kidney Disease (CKD): As mentioned earlier, CKD is a long-term condition where the kidneys gradually lose their ability to function. It is often linked to conditions like diabetes, high blood pressure, and glomerulonephritis.

2. Acute Kidney Injury (AKI): This sudden onset of kidney dysfunction is typically caused by factors such as dehydration, infections, or certain medications. Timely intervention can often reverse AKI.

3. Polycystic Kidney Disease (PKD): PKD is a genetic disorder characterized by the growth of cysts in the kidneys, leading to an increase in their size and potential impairment of function. It is crucial to consult the best kidney specialists in Surat to prevent further damage.

4. Glomerulonephritis: This inflammatory condition affects the glomeruli, the tiny filters within the kidneys. It can result from infections, immune system disorders, or other diseases.

What are the Symptoms of Kidney Disease?

In the early stages, kidney disease may be asymptomatic, making it crucial to be aware of potential signs as the condition progresses. Common symptoms include:

- Fatigue and weakness

- Swelling, particularly in the legs and ankles

- Changes in urination frequency and colour

- Persistent itching

- High blood pressure

- Shortness of breath

- Nausea and vomiting

- Loss of appetite

It’s essential to consult a healthcare professional if these symptoms arise, as early detection and intervention can slow the progression of kidney disease.

What are the Risk Factors for Developing Kidney Disease?

Understanding the risk factors for kidney disease is pivotal in taking proactive steps towards prevention. As explained by our kidney specialist in Surat at SIDS hospital, the key risk factors include:

1. Diabetes: Uncontrolled diabetes can damage blood vessels in the kidneys, leading to kidney disease.

2. High Blood Pressure: Hypertension is a leading cause of kidney damage. Managing blood pressure is crucial in preserving kidney health.

3. Age: The risk of kidney disease increases with age, especially after the age of 60.

4. Family History: Genetic factors can contribute to the risk of developing certain kidney diseases, such as PKD.

5. Smoking: Smoking can worsen kidney disease and interfere with medications used to treat it.

6. Obesity: Excess weight can strain the kidneys and increase the risk of diabetes and hypertension.

What is Kidney Failure?

Kidney failure, also known as end-stage renal disease (ESRD), occurs when the kidneys are no longer able to function adequately to sustain life. At this stage, individuals often require dialysis or kidney transplantation to survive. Kidney failure can result from the gradual progression of chronic kidney disease or, in some cases, from acute kidney injury.

Preventing Chronic Kidney Disease

According to our specialists at SIDS hospital who are considered as the best kidney specialists in Surat, prevention plays a crucial role in maintaining optimal kidney health. Here are essential measures to prevent chronic kidney disease:

1. Manage Blood Pressure: Regular monitoring and management of blood pressure are crucial. Lifestyle modifications and medication adherence may be necessary.

2. Control Diabetes: For individuals with diabetes, maintaining blood sugar levels within the target range is essential in preventing kidney damage.

3. Adopt a Healthy Diet: A diet low in salt, saturated fats, and refined sugars, combined with adequate hydration, supports kidney health. Fresh fruits, vegetables, and whole grains are excellent choices.

4. Stay Active: Regular physical activity promotes overall health, helps control blood pressure, and reduces the risk of obesity.

5. Quit Smoking: Smoking not only increases the risk of kidney disease but also hinders its treatment. Quitting smoking is a crucial step in kidney health.

6. Limit Alcohol Consumption: Excessive alcohol intake can contribute to kidney damage. Moderation is the key to maintaining kidney health.

Conclusion

Understanding the intricacies of kidney health, recognizing the signs of kidney disease, and adopting preventive measures are essential components of overall well-being. Regular check-ups, maintaining a healthy lifestyle, and addressing risk factors promptly contribute to the longevity of your kidneys. By taking a proactive approach to kidney health, you empower yourself to lead a fulfilling life with optimal renal function. If you experience symptoms or have concerns about your kidney health, consult with our healthcare professional at SIDS hospital, considered as one of the best hospital in Surat for personalized guidance and care.

#surat #sids hopital #specialist #kidney

0 notes

dzthenerd490 · 10 months ago

Text

Document of Interest: Medicine and Drugs

Control Drugs:

- Amnestics - Utilized to make the consumer forget

- Mnestics - Utilized to make the consumer remember

- Agnostics - makes consumers more open to otherwise incomprehensible anomalous phenomena. Often given to new Foundation personnel in very small dosages to keep them from developing trauma or insanity.

Medicine:

- Pernes - revolutionary Foundation medicine that puts the white blood cells in overdrive, allowing them to find cancer cells and devour then more effectively. Once the white blood cells start eating the cells they quickly start growing and burst, flooding nutrients into the body, mainly restoring what was lost to the cancer cells. Normally takes an hour to take effect and an additional hour for all cancer in the body to be removed with a 75% success rate. Should only be taken once a month as even taking it daily can lead to various vitamin overdosage and resulting in several complications such as kidney stones, stomach cramps, and other such complications. Exists in pill form and recommended that all Foundation staff take once a year, once a month if a serious form of cancer develops. Especially helpful to those with unstable regenerative abilities that can increase the chances of cancer.

- Santio - A medicine used by Foundation staff to clean the blood of any toxins and even force sickle cells to regenerate into normal blood cells. Especially useful for blood diseases that are impossible to cure or cause blood cells to form incorrectly. Also useful in anomalous diseases that eat blood cells or hide within the blood and cannot be extracted or cured by any other method. Exists as an injection form.

- Certium - a revolutionary Foundation medicine that can be used to repair damaged brain cells, reverse the damage of a bruised brain, and can even cure Alzheimer's of Stage 3 or lower. If the dosage is right, it is possible to even cure Stage 4 but unfortunately, Stage 5 and higher is still uncurable. Exists in pill form.

- Remate - an anomalous Foundation medicine that can revitalize the heart and make all its damaged parts wither away. Essentially reversing the age of the heart making it stronger and last longer than before. Perfect for healing the heart after irreversible damage caused by injury, common, and/or uncommon heart diseases. Exists in pill form, different version exists for lungs, liver, and kidneys.

- Durane - Foundation medicine used to stop the flow of blood of a patient, temporarily ceasing all functions of the body so that the doctor can stop them from bleeding to death. Extremely useful in keeping patients form getting unnecessary damage or infections during emergency surgery. Exists as emergency injection form.

- Turbune - Amazing Foundation medicine that strengthens the immune system exponentially allowing it to develop antibodies much faster to combat bacteria, viruses, parasites, and fungus much faster than a normal human ever could. Essentially someone with Turbune can be coughed on directly by hundreds of sick people and their immune system will kill all of the exposed diseases instantly. However, it's still possible for anomalous diseases to either overpower Turbune or perform much faster than it. As such its always recommended to view Turbune as a vaccine that should be taken before infection rather than a cure that can be taken after infection. Exists in both injection and pill form.

- Consumos - Complex medicine that forces the body to grow anomalous cells in the body. These cells will recognize the proper bone structure of the body and search for broken bone fragments and devour them, growing in population and size as a result. Once all bone pieces not in its correct place has been consumed the cells will flow to the parts of the bones where these pieces fell off from. Once the broken parts of the bone are found the cells will kill and condense themselves into new bone repairing it entirely. The cells are able to work so fast that the process never takes any longer than 10 minutes. 30 minutes being common for extreme cases. Exist as emergency injection form.

- Immortap - immortality drug created specifically for Foundation perks provided by Protocol "The Burdon We Share". So long as the user takes them once a week their cells will develop faster than they die allowing the user to live forever young and healthy. However, it only halts aging, their healing factors stay the same as the average human so anything that's commonly fatal can still kill them.

- duplexura - anomalous medicine that causes all platelets in the body to multiply rapidly when around open wounds ensuring healing happens much faster. Minor side effect of blood clot when there are no wounds on the body. Should only be used when there are cuts on the body. Exists in pill form.

- sangutem - medicine that increases the among of blood in the body and increases its flow. Is only to be used when the taker has had massive blood loss and has all their wounds patched so they don't bleed out profusely. Exists in injection form.

- sanatem - made form Foundation cultivated aloe vera and many other Foundation herbs. Meant to be the ultimate quick medicine that is used to disinfect and heal wounds. When placed on a bandage and placed over a wound it can quickly stop bleeding and make the skin heal faster. Though it's still recommended to rely more on other Foundation medicines. No known side effects but it has been confirmed at least 0.2% of the population is allergic and that unfortunately includes Foundation staff. So, it's best to confirm with patients first.

Weaponized Drugs:

- Rejupus - Anomalous drug that takes 10 minutes to take effect, once done, it consumes all the waist and nonessential fat of the body, converting it into an anomalous vitamin. This vitamin allows the body regenerate from small wounds and gunshots, the consumer run faster and much stronger, and go on without rest or need of the restroom. Amount of dosage determines longevity of the effect thought the recommended maximum is 24 hours. It is also recommended to take it after consuming a large meal. Not following either recommendation will lead to bad side effects such as muscle degradation, complications in the intestines, and massive fatigue after use.

- Demonarcotics - Performance enhancing drugs made from demons, each pill increases power of the consumer by 10%. However, its recommended to never take more than 2 as doing so makes the consumer becomes more demonic and aggressive even to allies the more pills they take. After taking about 5 pills their skin or eyes change color, and they grow horns; they are to no longer be considered human. Some are able to survive 7 but it's still recommended to never go over 2 and only take 4 in extreme situations.

- Wisp - anomalous drugs that allow the consumer to spit out laser blasts, capable of incinerating an entire person. Can become addictive for obvious reasons, must not be taken daily as doing so can lead to degradation of the bones and brain over time as well as the consumer emitting dangerous levels of Aspect Radiation.

- Evotari - Also known as Evolution's Nectar or SCP-ADK-3. Modified and refined to be less addictive and have no chance of mutagenic harmful effects like SCP-ADK-2. Created in a variety of version that allow the user to gain different abilities all of which are temporary to further ensure no long-term mutations will occur in the body. Such abilities given by Evotari include fire manifestation, lightning manifestation, ice manipulation, insect manifestation, biology manipulation, energy manifestation, energy manipulation, and other more specific abilities. Unfortunately, effects will permanently change the body and thus its recommended to only take one as a last resort.

- Faltem - An anomalous drug that can make a person seem dead when in reality their body is simply shut down and can easily be restarted like a machine. Physically no different to death as the organs don't move but the brain is still very active. The consumer can't move but can still comprehend everything around them, even clearer than before. Depending on the dosage can work anywhere of 5 minutes to 2 hours, any larger dosage can lead to irreversible organ damage and even death. Commonly used by MTF units in extremely specific covert operations or as fake suicide attempts to trick the enemy into thinking they won.

- Ianucum - Anomlaous drug that once consumed allows a person to teleport wherever they want. It's always recommended it's a place they've been before as teleporting anywhere else can lead to disasters consequences. Should never be taken more than once a day as taking two in the same 24 hours can cause the patches of skin to suffer necrosis and increase chances of cancer development. This gets worse the more the user takes these pills within 24 hours.

Potions:

- "Love" potion - Created by the DTASMW, used on captured Persons of Interest to influence them to talk about everything. Helps greatly for interrogations.

- Elemental potions - allows the drinker to manifest elements with amount and intensity based on the amount of potion taken. Much easier to produce than Evotari and thus is more widespread among MTF units and field researchers. However not as powerful and only lasts for about 10 minutes at maximum.

- Fatigue potion - Helps get rid of drowsiness from sleep and also relieve pain and fatigue from exercising or anything else that exerts the body. Daily consumption can help keep a person awake for two days however its recommended to rest afterwards as the body still needs actual sleep.

- Hunger potion - Famous among Foundation staff that are busy with experiments and don't want to waste time eating. A single bottle is enough to keep someone form needing food for an entire day. Again, its recommended to never rely on this potion for more than two days as the body still needs actual food.

- Sense potion - Highly favored by MTF units on dangerous missions, comes in five versions for the five senses. Each one only improves a single sense as having all five improved at once can greatly overwhelm the user. Allows the user to see and notice things they never could before.

- Vision potions - Comes in a wide selection for granting users different types of sight such as heat vision, x-ray vision, ultraviolet vision, nocturnal vision, and many more. In high demand from MTF units, Foundation researchers, agents, and even administrative staff.

SCP: HMF - Documents of Interest Hub

#DZtheNerd #SCP: Horror Movie Files #SCP Foundation #SCP Fanfiction #SCP AU #SCP #SCP Fanmade #SCP Documents of Interest #SCP DoI #DoI: Perks #DoI: Protocols #Department of Technology Alchemy Science Magic and Warfare #SCP-ADK

0 notes

diabetickidneydiseasehealth · 11 months ago

Text

Development of diabetic kidney disease

The progression of diabetic nephropathy can be categorized into five stages, ranging from mild to severe, each requiring varying diabetes treatments.

Stage 1: Hyperfiltration and Kidney Enlargement Phase

In this initial stage, associated with elevated blood glucose levels, kidney changes can be reversed through strict blood sugar control and insulin therapy over weeks to months.

Treatment focus:

Maintain a healthy lifestyle and manage factors contributing to atherosclerosis, such as high blood sugar, blood pressure, lipids, uric acid, blood viscosity, overweight, and smoking.

For diabetic patients with normal kidney function, aim for a daily protein intake of 0.8 grams per kilogram of body weight. Consider the impact on kidney function when selecting medications for blood pressure, lipids, and blood sugar.

Stage 2: Intermittent Microalbuminuria Phase

Characterized by kidney enlargement and increased filtration rate, this stage lacks clinical symptoms, with urinary protein excretion increasing after exercise.

Treatment focus:

Continue lifestyle interventions. Adjust daily protein intake to 0.6-0.8 grams per kilogram after a decrease in filtration rate. Prefer insulin over sulfonylurea drugs for blood sugar control.

Stage 3: Early Diabetic Kidney Disease Phase

Persistent microalbuminuria (30-300 mg in 24 hours) marks this stage, emphasizing the importance of low-protein diets, blood sugar control, and blood pressure management.

Treatment focus:

Implement a low-protein diet. Initiate insulin therapy early. Control blood pressure (≤130/80 mmHg) with renin-angiotensin system inhibitors. Monitor for kidney-harming factors.

Stage 4: Clinical Diabetic Kidney Disease Phase

Significant proteinuria (>500 mg in 24 hours) characterizes this stage, with an emphasis on aggressive blood sugar control and dietary management.

Treatment focus:

Opt for high-quality animal protein with a daily intake ≤0.6 grams per kilogram. Choose antidiabetic medications with less kidney excretion. Use antiplatelet medications. Strictly control blood pressure and lipids.

Stage 5: Kidney Failure Phase

Representing uremia, this stage requires either kidney dialysis or transplantation.

Treatment focus:

Follow a low-salt, low-protein, low-fat diet. Limit fluid intake as appropriate. Treat complications through specialized care. Dialysis and transplantation:

Recommended when glomerular filtration rate falls below 15 ml/min. Consider initiation slightly earlier than non-diabetic kidney disease patients.

Dialysis may be considered when blood creatinine levels reach 530-710 μmol/L and creatinine clearance is 10-15 ml/min. For effective kidney protection, early prevention is key, involving proactive blood sugar management, close monitoring, and lifestyle improvements. Early initiation of intensive insulin therapy can significantly reduce the risk of complications in diabetic nephropathy.

#Diabetic Kidney Disease #Finerenone #diabetic nephropathy #Diabetic #long-term diabetes #Kidney Disease #DKD #CKD #blood sugar #protein in the urine #kidney failure #eGFR #Blood Sugar Control #Obesity #Hypertension

0 notes

peachtreehillsvet · 2 years ago

Text

February is National Pet Dental Health Month

As a profession we spend the 28 days of February heavily focused on our pet’s dental health, which is great, but unfortunately not enough. It has been shown that periodontal disease is the number one health problem affecting small animal patients.1,2 It is even so significant that by 2 years of age, 80% of dogs and 70% of cats have some form of periodontal disease.3

As pet owners, we likely don’t focus lots of time and thought on our pet’s mouths, but we should! In humans, there are systemic consequences of poor dental health including impacts on our kidneys, liver, heart, and lungs. It is reported that human patients with periodontal disease are four times more likely to have multiple (3 or more) systemic maladies than those in good periodontal health.5

It may seem like a big ask to brush your dog and cat’s teeth daily, which can be true, but the benefits can be exponential. Even after a dental cleaning under anesthesia, plaque can form on the teeth within 24 hours.3,4 That plaque can cause localized inflammation at the gingival margin and lead to bleeding, redness, and discomfort. This term called GINGIVITIS is the early stages of gum disease and can be reversed with appropriate cleaning and therapy. Once the inflammation has progressed to the point where there are changes including bone loss, pocketing, and gum recession, among others, we have a diagnosis called PERIODONTAL DISEASE, which is not reversible.

So, you ask, what can we do as pet owners? I believe our big takeaways from dental health discussions are to figure out a plan that works for your family and your pet. Not every pup or everyone’s schedule is going to allow you to brush daily. Not every pet is going to chew on veterinary approved dental chews as recommended by the Veterinary Oral Health Council (VOHC). But there are multiple opportunities available to us daily that can improve the oral health of our patients.

It is also important to remember that even if we are performing bi-annual examinations on your pet, we can never fully examine every aspect of the oral cavity. This means appropriately timed Comprehensive Oral Health Assessment and Treatments (COHAT) under anesthesia are necessary to examine each tooth, measure periodontal pocketing, look for growths, perform radiographs, etc.

At Peachtree Hills Animal Hospital, we are committed to the highest quality care for your pet and want to do it in an inclusive environment that takes you the pet owner, and the pet into account. We want to ease worries, help create solutions, and give you the best curtailed advice that provides the best for your family. Keep in mind, if we are able to create a plan that reduces plaque, tartar, gingivitis, and periodontal disease, smaller dogs and cats live 15–20% longer if they receive dental care as needed throughout their life and larger dogs live 10–15% longer. Isn’t that amazing!?!

Please reach out if you have any questions.

Take Care, Mark Belyeu, DVM

References:

1. University of Minnesota Center for Companion Animal Health. National Companion Animal Study, 1996, p 3. 2. Lund EM, Armstrong PJ, Kirk CA, et al. Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States. JAVMA 1999; 214:1336-1341. 3. Wiggs RB, Lobprise HB. Periodontology. Veterinary Dentistry, Principals and Practice. Philadelphia: Lippincott – Raven, 1997, pp 186-231. 4. Quirynen M, Teughels W, Kinder Haake S, Newman MG. Microbiology of periodontal diseases. Carranza’s Clinical Periodontology. St. Louis: WB Saunders, 2006, pp 134-169. 5. Al-emadi a, Bissada n, Farah C, et al. systemic diseases among patients with and without alveolar bone loss. Quintessence Int 2006; 37(10):761-765.

Dental COHAT on canine patient under anesthesia PRIOR to cleaning and evaluation.

Dental COHAT on canine patient under anesthesia AFTER cleaning and evaluation.

References:

Originally published here: https://peachtreehillsvet.com/february-is-national-pet-dental-health-month/

#Peachtree Hills Animal Hospital

0 notes

gamingchair2022 · 3 years ago

Text

Kidney Disease Solution uncovered: Get all the facts

If you’ve been diagnosed with kidney disease, your first question to your doctor was probably along the lines of: “What can I do about it?” Unfortunately, you were probably left disappointed and frustrated by the answer.

The consensus of Western doctors is that kidney disease is a one-way journey. They say it only goes from bad to worse, and your best hope is to stall your decline with drugs before you succumb to dialysis or transplant. Along the way, you’re told to expect insomnia, muscle cramps, itching, swelling, fatigue, and a host of other unpleasant symptoms.

Like many people in your situation, you might be feeling powerless, angry, anxious, or even depressed about your diagnosis. It’s completely understandable; nobody wants to sit by and watch as their health slips away. Nobody wants to accept a future of medications, machines and surgeries. Nobody wants to give up years of quality time with their loved ones. Click here more information Kidney Disease Solution.

#kidney #kidney disease #kiddney solutions #chronic kidney disease stage 2 #chronic kidney disease stage 1 #adult polycystic kidney disease #chronic kidney disease stage 3 diet #anemia and kidney disease #can kidney disease be reversed

0 notes

sierrabed · 3 years ago

Text

My Endometriosis Journey Part 2:

What is Endometriosis?

“Endometriosis (en-doe-me-tree-O-sis) is an often painful disorder in which tissue similar to the tissue that normally lines the inside of your uterus — the endometrium — grows outside your uterus. Endometriosis most commonly involves your ovaries, fallopian tubes and the tissue lining your pelvis.”

In my last blog post, we learned that I have Stage II, which we will go into more later. I want to outline everything that I know about this in order to raise awareness about it, because it is scarily common in women, and a lot of women may have it and don’t even know. (I will link all of the sources used at the bottom of this post, so you can check them out for yourself!)

Endometriosis affects 1 out of 10 women in childbearing age (2-10% of women). The cause of endometriosis is unknown, and there is currently no cure, although there is treatment. There are some theories as to why endometriosis happens:

1. one theory suggests that during menstruation, some of the tissue backs up through the fallopian tubes, into the abdomen, like a reverse menstruation, where it attaches and grows.

2. another theory suggests that endometrial tissue may travel and implant via blood or lymphatic channels, similar to the way cancer cells spread.

3. a third theory suggests that cells in any location may transform into endometrial cells.

This disease is also genetic, and can appear in families, which is true in my case. My grandmother, mother, aunt, and myself all have a form of this disease.

Endometriosis can be found on the ovaries, the fallopian tubes, ligaments that support the uterus, the space between the uterus and the rectum, the space between the uterus and bladder, the outer surface of the uterus, and the lining of the pelvic cavity. Endometriosis has been found in every organ and anatomical structure in the body, but it is most commonly found in the places listed above. Because it can grow on every organ, this includes the kidneys, eyes, liver, pancreas, brain, bone, heart, skin, and nasal cavity if severe enough.

The symptoms of endometriosis are as follows: pain, especially excessive menstrual cramps that may be felt in the abdomen or lower back, abnormal or heavy menstrual flow, infertility, painful urination during menstrual periods, painful bowel movements during menstrual periods, or other gastrointestinal problems such as diarrhea, constipation, or nausea.

One important thing to note is that the pain that a woman experiences is NOT directly correlated to how severe the disease is. A women with Stage 4 endometriosis may experience no pain whatsoever, whereas a woman with Stage 1 may have inconsolable pain.

There is an important connection to make between women who have endometriosis and those who struggle with infertility. Having endometriosis does not guarantee that you will be infertile, but it does increase your chances. 24-50 percent of women who experience infertility are found to have endometriosis. In these cases, surgery to remove it can restore fertility. In other cases ( a very small percentage) women remain infertile.

Diagnosis begins with a gynecologist completing a physical examination, including a pelvic exam, but can ONLY be certain through a laparoscopic surgery. If the endometriosis is progressed enough, it can be diagnosed just by visually seeing it, but sometimes in stage 1, you may need a biopsy of tissue to determine. A laparoscopy is a minor surgical procedure where a thin tube with a camera is inserted into the abdomen through a small incision.

It is important to note that it takes an average of 7 years. This is insane. Not a lot of women are going to persist through 7 years of doctors in order to get diagnosis, and surgery. It should not be this hard to get a diagnosis, which is why I am trying to raise awareness, because mine took 5 years.

There are four stages of endometriosis, which I will go into further detail. The most common system used is the American Society for Reproductive Medicine Scale (ASRM). The Endometriosis Foundation of America has their own classification, but for my purposes, I will be combining the two in my explanation, because they are similar:

Stage 1 (peritoneal endometriosis): Minimal with few superficial implants. The membrane that lines the abdomen is infiltrated with endometriosis tissue.

Stage 2 (Ovarian Endometriosis): Mild with more and deeper implants. It is established within the ovaries, and these forms of ovarian cysts are of particular concern due to their risk of breaking and spreading endometriosis within the pelvic cavity.

Stage 3 (Deep Infiltrating Endometriosis I (DIE I)): Moderate with many deep implants. Small cysts on one or both ovaries. Presence of filmy adhesions. The first form of deep infiltrating endometriosis involves organs within the pelvic cavity. This can include the ovaries, rectum, uterus, and significantly distort the anatomy of the pelvic organs.

Stage 4 (Deep Infiltrating Endometriosis II (DIE II)): Severe with many deep implants. Large cysts on one or both ovaries and many dense adhesions. The other more extreme form of Deep Infiltrating Endometriosis involves organs both within and outside of the pelvic cavity. This can include bowels, appendix, diaphragm, heart and lungs, among others.

Remember, that the stage of the disease does not correlate with the amount of pain that the woman experiences.

*Personally I do not like that they use the acronym DIE in the classifications. OOF.

If a laparoscopic surgery does not succeed, a laparotomy (a more extensive surgery) can be used to remove as much of the tissue as possible without damaging healthy tissue. If this is not successful, many women use a hysterectomy to remove the uterus and possibly the ovaries to prevent tissue from growing back.

A lot of treatment for endometriosis is pain management, and laparoscopic surgery to remove the disease. There is no official cure.

If you think you have endometriosis, please reach out to your OBGYN, and if you are in the South Central Pennsylvania Region, please reach out to Dr. Harkins, he is an amazing doctor that has helped many women already, including myself.

You are not alone. This disease affects all and everyone. Here are some celebrities with endometriosis: Amy Schumer, Tia Mowry-Hardrict, Lena Dunham, Chrissy Teigen, Mandy Moore, Julianne Hough, Halsey, Whoopi Goldberg, and Alaia Baldwin Aronow.

Sources:

https://www.hopkinsmedicine.org/health/conditions-and-diseases/endometriosis

http://nezhat.org/endometriosis-treatment/where-does-endometriosis-grow/#:~:text=Endometriosis%20has%20been%20found%20in,anatomical%20structure%20in%20the%20body.

https://www.advancedgynaecologymelbourne.com.au/endometriosis/stages

https://academic.oup.com/humrep/article/18/4/756/596537

https://www.everydayhealth.com/endometriosis/living-with/celebrities-who-speak-endometriosis/

Some great social media resources if you want to do your own research:

@/endohealthhub on Instagram

@/endometriosismemes on Instagram

@/endogirlgang on Instagram

@/chronicallyillgoddess on Instagram

@/endohumour on Instagram

@/the_endo_space on Instagram

‘The Endo Space’ Group on Facebook

‘Endometriosis Support Group’ Group on Facebook

‘Undiagnosed Illness Support Group’ Group on Facebook

and if you are in South Central Pennsylvania, check out ‘Central PA Endometriosis Support Network’ Group on Facebook.

#endometriosis #endometriosis diagnosis #endometriosis awareness #diagnosis #endometriosis support #endometriosis sources #endometriosis research #sierrabed

5 notes · View notes

clowngremlin · 4 years ago

Text

TH*N//SPO/ PR//O A//N/////A DO NOT INTERACT OR I’LL BLOCK U

actually i am going to talk about being sick in more detail because i didnt think this was something that could happen to young people, because im only 24, but i have stage 3 kidney disease......i wanted to talk about it more openly because i didnt think kidney disease was something young people could get, but anorexia, especially the purging subtype which is the type that i had, can cause kidney damage.....the outcome for me looks good, like im almost certainly not going to die from it or possibly even need to be hospitalized and go on dialysis, because they caught it early enough that the damage my eating disorder and excessive caffeine abuse did can be reversed and i can go on to being healthy and fine!! i really cant stress this enough, but if u have struggles with body image issues, please don’t start to starve urself or purge......it can do a lot of damage on ur body and even kill u if it goes on for long enough......i’m really lucky that i went to my doctor and he wanted me to do some routine tests just as a check up because i hadnt had a full check up done in a long time and i had such debilitating anorexia, so i will likely be fine and i am very optimistic about it! i am really scared though, but it has gotten easier every day to deal with the fears.....i was told on monday i was sick and idk it just feels like a nightmare. i’m lucky that i can still fix the damage done to me by my eating disorder and other unhealthy habits like excessive caffeine consumption, but nothing in life is for sure, that’s what my mom told me, so i have to take really good care of myself, which i am! i was already doing almost everything my doctor told me to do in order to recover from this, and i am in recovery from my anorexia and i have been for a while!! i have to go get more tests done this upcoming week so i am scared but i am trying to be brave!! i really mean this, if any of u are struggling with an eating disorder, please get help, because i went for so long without getting help and now im like Sick because of it.....my dm’s and ask are open to anyone who needs to talk, because i know that not saying anything just makes it worse and as time goes on, ur more likely to do damage to ur body and it gets harder to recover......something that helped me be able to recover was having supportive friends and my boyfriend gavin!! if u are struggling with an eating disorder, u deserve help, u deserve to get better and u deserve to eat!! please feel free to reach out to me and i’ll try my best to get back to u as fast as i can but im like a dude in college who is also struggling with being sick and my mental health as well, and im not a professional therapist by all mean but i try to be a good listener!!! if u think no one cares about u and u dont want to get better, just know that i care about u and that u are worthy of recovering!! if u read all this, thanks for reading, this is really hard for me to talk about it but i decided that i think i SHOULD talk about it, especially given the stigma around eating disorders, especially men having eating disorders, which is one of the reasons i went so long without help, because people didnt think there was anything wrong with me because i was a man and they didnt think men could have problems like this!! anyways thanks everyone for reading!!

#the wretched gremlin strikes again #illness mention #eating disorder mention #disordered eating mention #eating disorders //#ed mention #ed ///#disordered eating ///#ask to tag

10 notes · View notes

rayarmat · 4 years ago

Text

A Guide to Outpatient COVID Treatment: Step-By-Step Doctors’ Plan That Could Save Your Life

Recently, Dr. Peter McCullough, MD, of Baylor University Medical Center in Dallas testified to Texas Senate HHS Committee about how mass media and even some government agencies are silencing clinical outpatient evidence for effective treatment of COVID19 and instead push vaccines only (video shown below).

Treatments like those mentioned by Dr. McCullough can be found in sites like https://c19early.com/ but specifically, McCullough refers to the following Appendix to a document published by Association of American Physicians and Surgeons (AAPSonline.org) as an educational resource. It is based on a paper published in American Journal of Medicine (link), by Dr. Peter McCullough and 22 other clinicians (MDs) and researchers (PhDs).

“Seek early treatment and be your own advocate. All of the physicians contributing to this booklet are on the frontlines treating outpatients at the first signs of COVID illness. Studies in the US and many other countries clearly show that patients who are treated within the first 5 days of symptoms have better outcomes using the combination of medications in the algorithm below.”

COVID-19 hospitalizations and death can be reduced with outpatient treatment.

Principles of COVID-19 outpatient care include: 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy 5) administration of oxygen, monitoring, and telemedicine.

“For the ambulatory patient with recognized early signs and symptoms of COVID-19, often with nasal real-time reverse transcription or oral antigen testing pending, the following 4 principles could be deployed in a layered and escalating manner depending on clinical manifestations of COVID-19-like illness and confirmed infection: 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, and 4) antiplatelet/antithrombotic therapy. Because the results of testing could take up to a week to return, treatment can be started before the results are known. For patients with cardinal features of the syndrome (ie, fever, body aches, nasal congestion, loss of taste and smell, etc.) and suspected false-negative testing, treatment can be the same as those with confirmed COVID-19. Future randomized trials are expected to confirm, reject, refine, and expand these principles. In this article, they are set forth in emergency response to the growing pandemic as shown in Figure 1 .

Treatment algorithm for COVID-19-like and confirmed COVID-19 illness in ambulatory patients at home in self-quarantine. BMI = body mass index; CKD = chronic kidney disease; CVD = cardiovascular disease; DM = diabetes mellitus; Dz = disease; HCQ = hydroxychloroquine; Mgt = management; O2 = oxygen; Ox = oximetry; Yr = year.

The basic groups of prescription medicines and other therapies used in COVID-19:

▪ Combination anti-viral medicines started as soon as symptoms occur ▪ Medicines to decrease inflammation, such as corticosteroids (called immunomodulators)

▪ Anticoagulant therapy to prevent blood-clots that can cause strokes, heart attacks, kidney shut-down, and death.

▪ Non-prescription supportive treatments with zinc, vitamin D, vitamin C, electrolyte drinks such as Pedialyte, and others.

▪ Home-based oxygen support, such as with an oxygen concentrator. These machines are available by physician prescription from home health medical supply businesses and are covered on most medical insurance plans.

I. Antiviral Agents:

These must be started quickly at STAGE I (Days 1-5):

Symptoms include sore throat, nasal stuffiness, fatigue, headaches, body aches, loss of taste and/or smell, loss of appetite, nausea, diarrhea, fever.

These medicines stop the virus from (1) entering the cells and (2) from multiplying once inside the cells, and they reduce bacterial invasion in the sinuses and lung:

▪ *Hydroxychloroquine (HCQ) with azithromycin (AZM) or doxycycline

▪ Ivermectin with azithromycin (AZM) or doxycycline

Either combination above must also include zinc sulfate or gluconate, plus supplemental vitamin D, and vitamin C. Some doctors also recommend adding a B complex vitamin.

Zinc is critical. It helps block the virus from multiplying.

Hydroxychloroquine is the carrier taking zinc INTO the cells to do its job.

An educational resource from The Association of American Physicians and Surgeons (AAPSonline.org) 16

II. Anti-inflammatory Agents - Corticosteroids (“steroids”): Oral and Nebulized.

These are started at STAGE II (Days 3-14) to reduce inflammation, the cause of added damage to the lungs and critical organs. Symptoms include worsening cough, difficulty breathing, chest heaviness/tightness or chest pain.

As inflammation damages the airways interfering with normal oxygen-carbon dioxide exchange, blood oxygen levels drop and people experience loss of focus, drowsiness, confusion, difficulty concentrating, low energy and severe fatigue.

The exaggerated Inflammation response in COVID further increases the risk of blood clots.

Prescription medicines and other support added now to Stage I medicines are: ▪ nebulized budesonide to help penetrate the lungs and reduce inflammation ▪ oral prednisone, methylprednisolone, dexamethasone

▪ colchicine – may also be added to reduce inflammation

▪ full strength adult aspirin 325 mg to reduce inflammation and risk of blood clots ▪ home oxygen concentrator may be needed to improve oxygen levels (requires physician prescription)

III. Prescription Anticoagulants (“blood thinners”):

STAGE III (Day 7 and beyond): Symptoms seen in Stage II intensify. Difficulty breathing becomes extreme, oxygen levels drop sharply, risk of heart attack or stroke increases. At this point, people are critically ill.

The medicines to be added to Stage I and II medicines now include:

▪ Aspirin 325 mg unless told not to take by your doctors

▪ And/or low molecular weight heparin injections (e.g. enoxaparin [Lovenox]) OR

▪ apixaban (Eliquis), or rivaroxaban (Xarelto), or dabigatran (Pradaxa) or

edoxaban (Savaysa) in standard doses for 5 to 30 days

If these added steps do not lead to improvement, or the patient becomes unstable, a 911 call is warranted for ER evaluation and hospital admission so that more aggressive IV medications (such as remdesivir, Regeneron, and others) may be considered, and more intensive ventilation regimens are possible in ICU settings.

IV. Vitamins, Supplements, and Oxygen.

▪ Zinc sulfate, gluconate or citrate. These forms are available in pharmacies, health food stores, and sold online. Zinc sulfate 220 mg provides 50 mg elemental zinc, the recommended anti-viral dose. Zinc in the form of zinc picolinate form is not recommended following reports of liver damage and tumors from studies about 20 years ago. Following these reports, the German Commission E that regulates supplements used in medical practice in Germany banned this form of zinc.

An educational resource from The Association of American Physicians and Surgeons (AAPSonline.org) 17

▪ Vitamin D3, preferable in oil in capsules for better absorption. Recommended doses for anti-viral benefit vary from 5000 IU or more for 5-30 days

▪ Vitamin C with bioflavonoids for antioxidant, anti-inflammatory effects. Dose

recommendations from our contributors vary from 1000 mg (1 gram) once or twice a day up to 4 or more times a day.

▪ A word about quercetin. Some physicians are recommending this supplement to reduce viral illnesses because quercetin acts as a zinc ionophore to improve zinc

uptake into cells. It is much less potent than HCQ as a zinc transporter, and it does

not reach high concentrations in lung cells that HCQ does. Quercetin may help

reduce risk of viral illness if you are basically healthy. But it is not potent enough to replace HCQ for treatment of COVID once you have symptoms, and it does not

adequately get into lung tissue unless you take massive doses (3-5 grams a day),

which cause significant GI side effects such as diarrhea.

Control of Contagion

A major goal of self-quarantine is the control of contagion. Many sources of information suggest the main place of viral transmission occurs in the home. Facial covering for all contacts within the home as well as frequent use of hand sanitizer and hand washing is mandatory. Sterilizing surfaces such as countertops, door handles, phones, and other devices is advised. When possible, other close contacts can move out of the domicile and temporarily stay with others not ill with SARS-CoV-2. Findings from multiple studies indicate that policies concerning control of the spread of SARS-CoV-2 are effective and extension into the home as the most frequent site of viral transfer is paramount.

Reduction of Self-Reinoculation

It is well-recognized that COVID-19 exists outside the human body in a bioaerosol of airborne particles and droplets. Because exhaled air in an infected person is considered to be “loaded” with inoculum, each exhalation and inhalation is effectively reinoculation. In patients who are hospitalized, negative pressure is applied to the room air largely to reduce spread outside of the room. We propose that fresh air could reduce reinoculation and potentially reduce the severity of illness and possibly reduce household spread during quarantine. This calls for open windows, fans for aeration, or spending long periods of time outdoors away from others with no face covering to disperse and not reinhale the viral bioaerosol.

Combination Antiviral Therapy

Rapid and amplified viral replication is the hallmark of most acute viral infections. By reducing the rate, quantity, or duration of viral replication, the degree of direct viral injury to the respiratory epithelium, vasculature, and organs may be lessened. Additionally, secondary processes that depend on viral stimulation, including the activation of inflammatory cells, cytokines, and coagulation, could potentially be lessened if viral replication is attenuated. Because no form of readily available medication has been designed specifically to inhibit SARS-CoV-2 replication, 2 or more of the nonspecific agents listed here can be entertained. None of the approaches listed have specific regulatory approved advertising labels for their manufacturers; thus all would be appropriately considered acceptable “off-label” use.

Zinc Lozenges and Zinc Sulfate

Zinc is a known inhibitor of coronavirus replication. Clinical trials of zinc lozenges in the common cold have demonstrated modest reductions in the duration and or severity of symptoms. By extension, this readily available nontoxic therapy could be deployed at the first signs of COVID-19. Zinc lozenges can be administered 5 times a day for up to 5 days and extended if needed if symptoms persist. The amount of elemental zinc lozenges is <25% of that in a single 220-mg zinc sulfate daily tablet. This dose of zinc sulfate has been effectively used in combination with antimalarials in early treatment of high-risk outpatients with COVID-19.

Antimalarials

Hydroxychloroquine (HCQ) is an antimalarial/anti-inflammatory drug that impairs endosomal transfer of virions within human cells. HCQ is also a zinc ionophore that conveys zinc intracellularly to block the SARS-CoV-2 RNA-dependent RNA polymerase, which is the core enzyme of the virus replication. The currently completed retrospective studies and randomized trials have generally shown these findings: 1) when started late in the hospital course and for short durations of time, antimalarials appear to be ineffective, 2) when started earlier in the hospital course, for progressively longer durations and in outpatients, antimalarials may reduce the progression of disease, prevent hospitalization, and are associated with reduced mortality. In a retrospective inpatient study of 2541 patients hospitalized with COVID-19, therapy associated with an adjusted reduction in mortality was HCQ alone (hazard ratio [HR] = 0.34, 95% confidence interval [CI] 0.25-0.46, P <0.001) and HCQ with azithromycin (HR = 0.29, 95% CI 0.22-0.40, P <0.001). HCQ was approved by the US Food and Drug Administration in 1955, has been used by hundreds of millions of people worldwide since then, is sold over the counter in many countries, and has a well-characterized safety profile that should not raise undue alarm. Although asymptomatic QT prolongation is a well-recognized and infrequent (<1%) complication of HCQ, it is possible that in the setting of acute illness symptomatic arrhythmias could develop. Data safety and monitoring boards have not declared safety concerns in any clinical trial published to date. Rare patients with a personal or family history of prolonged QT syndrome and those on additional QT prolonging, contraindicated drugs (eg, dofetilide, sotalol) should be treated with caution and a plan to monitor the QTc in the ambulatory setting. A typical HCQ regimen is 200 mg bid for 5 days and extended to 30 days for continued symptoms. A minimal sufficient dose of HCQ should be used, because in excessive doses the drug can interfere with early immune response to the virus.

Azithromycin

Azithromycin is a commonly used macrolide antibiotic that has antiviral properties mainly attributed to reduced endosomal transfer of virions as well as established anti-inflammatory effects. It has been commonly used in COVID-19 studies initially based on French reports demonstrating markedly reduced durations of viral shedding, fewer hospitalizations, and reduced mortality combination with HCQ as compared to those untreated. In the large inpatient study (n = 2451) discussed previously, those who received azithromycin alone had an adjusted HR for mortality of 1.05, 95% CI 0.68-1.62, and P = 0.83.23 The combination of HCQ and azithromycin has been used as standard of care in other contexts as a standard of care in more than 300,000 older adults with multiple comorbidities. This agent is well-tolerated and like HCQ can prolong the QTc in <1% of patients. The same safety precautions for HCQ listed previously could be extended to azithromycin with or without HCQ. Azithromycin provides additional coverage of bacterial upper respiratory pathogens that could potentially play a role in concurrent or secondary infection. Thus, this agent can serve as a safety net for patients with COVID-19 against clinical failure of the bacterial component of community-acquired pneumonia. The same safety precautions for HCQ could be extended to azithromycin with or without HCQ. Because both HCQ and azithromycin have small but potentially additive risks of QTc prolongation, patients with known or suspected arrhythmias or taking contraindicated medications or should have more thorough workup (eg, review of baseline electrocardiogram, imaging studies, etc.) before receiving these 2 together. One of many dosing schemes is 250 mg po bid for 5 days and may extend to 30 days for persistent symptoms or evidence of bacterial superinfection.

Doxycycline

Doxycycline is another common antibiotic with multiple intracellular effects that may reduce viral replication, cellular damage, and expression of inflammatory factors. This drug has no effect on cardiac conduction and has the main caveat of gastrointestinal upset and esophagitis. As with azithromycin, doxycycline has the advantage of offering antibacterial coverage for superimposed bacterial infection in the upper respiratory tract. Doxycycline has a high degree of activity against many common respiratory pathogens including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, anaerobes such as Bacteroides and anaerobic/microaerophilic streptococci and atypical agents like Legionella, Mycoplasma pneumoniae, and Chlamydia pneumoniae. One of many dosing schemes is 200 mg po followed by 100 mg po bid for 5 days and may extend to 30 days for persistent symptoms or evidence of bacterial superinfection. Doxycycline may be useful with HCQ for patients in whom the HCQ-azithromycin combination is not desired.

Favipiravir

Favipiravir, an oral selective inhibitor of RNA-dependent RNA polymerase, is approved for ambulatory use in COVID-19 in Russia, India, and other countries outside of the United States.35 It has been previously used for treatment of some life-threatening infections such as Ebola virus, Lassa virus, and rabies. Its therapeutic efficacy has been proven in these diseases. Like, the antimalarials and antibiotics, favipiravir has no large-scale randomized trials completed at this time, given the short time frame of the pandemic. A dose administration could be 1600 mg po bid on day 1, following by 600 mg po bid for 14 days.

Immunomodulators

The manifestations of COVID-19 that prompt hospitalization and that may well lead to multiorgan system failure are attributed to a cytokine storm. The characteristic profile of a patient acutely ill with COVID-19 includes leukocytosis with a relative neutropenia. These patients have higher serum level of cytokines (ie, TNF-α, IFN-γ, IL-1β, IL-2, IL-4, IL-6, and IL-10) and C-reactive protein than control individuals. Among patients with COVID-19, serum IL-6 and IL-10 levels appear even more elevated in the critically ill. As with any acute inflammatory state, early treatment with immunomodulators is expected to impart greater benefit. In COVID-19, some of the first respiratory findings are nasal congestion, cough, and wheezing. These features are due to excess inflammation and cytokine activation. Early use of corticosteroids is a rational intervention for patients with COVID-19 with these features as they would be in acute asthma or reactive airways disease. The RECOVERY trial randomized 6425 hospitalized patients with COVID-19 in a 2:1 ratio to dexamethasone 6 mg po/IV daily for up to 10 days and found dexamethasone reduced mortality (HR = 0.65, 95% CI 0.51-0.82, P <0.001). One potential dosing scheme for outpatients starting on day 5 or the onset of respiratory symptoms is prednisone 1 mg/kg given daily for 5 days with or without a subsequent taper.

Colchicine

Colchicine is a nonsteroidal antimitotic drug that blocks metaphase by binding to the ends of microtubules to prevent the elongation of the microtubule polymer. This agent has proven useful in gout and idiopathic recurrent pericarditis. The GRECCO-19 randomized open-label trial in 105 hospitalized patients with COVID-19 found that colchicine was associated with a reduction in D-dimer levels and improved clinical outcomes. The clinical primary end point (2-point change in World Health Organization ordinal scale) occurred in 14.0% in the control group (7 of 50 patients) and 1.8% in the colchicine group (1 of 55 patients) (odds ratio, 0.11; 95% CI, 0.01-0.96; P = 0.02). Because the short-term safety profile is well understood, it is reasonable to consider this agent along with corticosteroids in an attempt to reduce the effects of cytokine storm. A dosing scheme of 1.2 mg po, followed by 0.6 mg po bid for 3 weeks can be considered.

Antiplatelet Agents and Antithrombotics

Multiple studies have described increased rates of pathological macro- and micro-thrombosis. Patients with COVID-19 have described chest heaviness associated with desaturation that suggests the possibility of pulmonary thrombosis. Multiple reports have described elevated D-dimer levels in acutely ill patients with COVID-19, which has been consistently associated with increased risk of deep venous thrombosis and pulmonary embolism. Necropsy studies have described pulmonary microthrombosis in COVID-19. These observations support the notion that endothelial injury and thrombosis play a role oxygen desaturation, a cardinal reason for hospitalization and supportive care. Based on this pathophysiologic rationale, aspirin 81 mg daily can be administered as an initial antiplatelet and anti-inflammatory agent. Ambulatory patients can be additionally treated with subcutaneous low-molecular-weight heparin or with short-acting novel anticoagulant drugs in dosing schemes similar to those use in outpatient thromboprophylaxis. In a retrospective study of 2773 inpatients with COVID-19, 28% received anticoagulant therapy within 2 days of admission, and despite being used in more severe cases, anticoagulant administration was associated with a reduction in mortality (HR = 0.86 per day of therapy, 95% CI: 0.82-0.89; P <0.001). Additional supportive data on the use anticoagulants reducing mortality has been reported in hospitalized patients with elevated D-dimer levels and higher comorbidity scores.53 Many acutely ill outpatients also have general indications for venous thromboembolism prophylaxis applicable to COVID-19.

Delivery of Oxygen and Monitoring

Because ambulatory centers and clinics have been reticent to have face-to-face visits with patients with COVID-19, telemedicine is a reasonable platform for monitoring. Clinical impressions can be gained with audio and video interviews by the physician with the patient. Supplemental information, including vital signs and symptoms, will be important to guide the physician. A significant component of safe outpatient management is maintenance of arterial oxygen saturation on room air or prescribed home oxygen under direct supervision by daily telemedicine with escalation to hospitalization for assisted ventilation if needed. Self-proning could be entertained for confident patients with good at-home monitoring.

Many of the measures discussed in this article could be extended to seniors in COVID-19 treatment units in nursing homes and other nonhospital settings. This would leave the purposes of hospitalization to the administration of intravenous fluid and parenteral medication, assisted pressure or mechanical ventilation, and advanced mechanical circulatory support.”

youtube

This is the group’s statement on vaccines:

“Vaccines in Development:

Several vaccine models are being investigated for SARS-CoV-2 (COVID-19) including DNA and RNA vaccines. These vaccines take genetic information from other sources that is introduced into the cells. This information includes instructions to produce a SARS2-like viral antigen itself, and the immune system then reacts to it to develop immunity to the virus.

The most important consideration before approving a vaccine for human use is to make sure that the vaccine is safe and effective. Developing safe and controlled infection models for humans normally takes many years of phased testing in the lab and then in humans. Many physicians and scientists have been concerned that vaccine manufacturers, with government support, are speeding up this process in ways that are not allowing adequate time for the usual phased testing leading up to human clinical trials. Two vaccine manufacturers already have voluntarily paused their clinical trials in people due to serious adverse events.

Currently, there are no RNA-based vaccines approved for human use so it would seem prudent to take the time needed to ensure safety. Vaccines for RNA viruses are notoriously challenging and difficult to develop. We still, after all these years since AIDS emerged in the 1980s, do not have a vaccine for the AIDS virus, or the SARS-1 coronavirus that emerged in 2002-2003, and both are RNA viruses.

Several attempts have been made to create vaccines for coronavirus and other respiratory viruses but none of the vaccines have survived the testing phases. The vaccine trials for SARS-1 from 2003, for example, was shut down because it produced autoimmune hypersensitivity reactions when exposed to the natural virus after immunization in animal studies.

Another problem is that the SARS-2 virus has already shown many mutations. Viruses adapt to the environment to survive. Like the flu virus, it is difficult to predict what mutations will occur and circulate around the world each season. A new vaccine must be reformulated to adjust to the changing genetic makeup of the SARS-2 virus.

Even the best vaccines for flu are only about 30-60% effective. Compare that with an effectiveness for improvement ranging from 64% to more than 90% in more than 100 new studies showing early, outpatient treatment with our existing medications described in chapters.

As research on the vaccine continues, safety and effectiveness are of primary concern. The good news is there are very safe and effective early treatments already available as we described in Chapter 3. Clearly, early, home-based treatment has now been so successful and offers so much hope, there is less urgency to have a vaccine.”

You can sign up to receive the full protocol here: https://aapsonline.org/covidpatientguide/ or find the research paper here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410805/

#coronavirus #medicine #pandemic #virus #ivermectin tablets

5 notes · View notes

rebuildinglife2-blog · 4 years ago

Text

7 Most Common Men's Health Issues And How To Fight Them

Compared to women, men are more likely to make risky choices including drinking alcohol, using tobacco and failing to see their doctor for regular checkups. This type of behavior combined with genetic predisposition can put men at greater risk for certain type of men’s health issues. However, understanding the risk of these issues is the first step in learning how to reduce them and improve your long-term health.

Talking with your doctor about preventative care is the best way to tackle a health issue before it gets out of control. Here are some of the top men’s health issues and tips on what you can do to prevent them.

EXTREME FATIGUE

If you find that you can’t get out of your daytime sluggishness, you may want to talk with your doctor to check for vitamin deficiencies or about what might be behind the cause of your fatigue. There may not always be a serious underlying issue behind your tiredness, but it’s important to fix it before it starts to interfere with your personal and professional life.

Promote sleep by avoiding alcohol, technology and food before bedtime. Sleep can help to restore your mind and body, so by taking measures that can allow you to sleep longer and undisturbed, you should notice a drastic improvement in your fatigue.

WEIGHT AND OBESITY

Getting older can make it harder to find time to stay active and make healthy food choices. Plus, your metabolism slows down with age. This makes it all the more important to eat healthier and exercise routinely. Obesity is often liked to serious health issues such as heart disease, diabetes and stroke, but it can be entirely avoided and reversed with some lifestyle changes.

STRESS

Stress is one of the unhealthiest issues that can affect men. It can lead to muscle tension, high blood pressure, hormonal imbalances and issues with digestion and reproduction. It also contributes to a lot of the health issues mentioned above, which is why controlling your stress level is something that should be practiced daily.

De-stressing is important to your overall health. Find activities and hobbies that help you to relax, while also trying to incorporate healthy amounts of exercise. If you’re having trouble relaxing or find that stress is just too hard to manage, speak with your doctor about more options that can help balance your mind and body.

HEART DISEASE

According to the American Heart Association, 1 in 3 men are living with some form of cardiovascular disease. If you’re concerned about your risk of developing heart disease, talk with your doctor about your family history, as well as your blood pressure and cholesterol levels.

Fortunately, heart disease may be avoided by regularly checking your blood levels and keeping up with a healthy lifestyle. Smoking should be avoided and alcohol consumption should be limited in order to better prevent heart disease.

PROSTATE CANCER

Although prostate cancer is one of the most common types of cancers in men, it is also one of the most successfully treated (when found in early stages). Symptoms to look out for may include difficulty and increases in urinating, but a lot of men have no symptoms at all.

A total of 4 in 10 cases are diagnosed late, which can make prostate cancer more difficult to treat. Looking for any signs of symptomatic changes and talking with your doctor can be vital. It’s important to understand that the prostate enlarges naturally with age, which is often harmless. However, you should ask your doctor about conducting both a blood test and prostate exam in order to thoroughly investigate.

DIABETES

Diabetes in men can lead to greater risk for sexual impotence and lower testosterone levels. These diabetic complications can contribute to depression and anxiety. If left untreated, diabetes can influence nerve and kidney damage, stroke and cardiovascular disease.

Blood testing for glucose levels and HbA1c is recommended for men who have a family history of diabetes and high blood pressure. There are plenty of options to help manage diabetes and continue living productively. In addition, type 2 diabetes is potentially reversible with lifestyle changes that include a healthy diet, exercise and weight loss.

DEPRESSION

This invisible ailment poses a large threat to men’s health if left untreated. The suicide rate is 3.5 times higher for men than women, often because of their unlikeliness to use resources for treatment. Luckily, the most effective form of treatment begins with just a conversation.

The best ways to help manage depression include communicating your situation with loved ones and seeking professional help. If you are experiencing suicidal thoughts, please seek help immediately by calling your local emergency number.

Living a healthy lifestyle filled with a balanced diet, exercise and routinely visiting your doctor are the most effective ways to lower your risk of health issues. Talk with your doctor about what you can do to get started in preventative care, so that you can tip the scales in your favor.

If you want to learn more click on this link male hormone replacement therapy orlando.

1 note · View note