#Skeletal muscle cells

[humancelltournament]

Human Cell Tournament Round 1

Propaganda!

Skeletal muscle cells are the individual contractile cells within a muscle, and are often termed as muscle fibers. A single muscle such as the biceps in a young adult male contains around 253,000 muscle fibers. Skeletal muscle fibers are multinucleated with the nuclei often referred to as myonuclei. Many nuclei are needed by the skeletal muscle cell for the large amounts of proteins and enzymes needed to be produced for the cell's normal functioning. A single muscle fiber can contain from hundreds to thousands of nuclei. A muscle fiber for example in the human biceps with a length of 10 cm can have as many as 3,000 nuclei. Unlike in a non-muscle cell where the nucleus is centrally positioned, the myonucleus is elongated and located close to the sarcolemma.

Acetylcholinesterase (ACHE) is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.

[medicomunicare]

Set these "satellites" on their mighty wings: pity Wingless is so "sticky" to forbid the messenger to take off

Set these “satellites” on their mighty wings: pity Wingless is so “sticky” to forbid the messenger to take off

WNT messenger proteins are crucial for a variety of cellular functions. WNT signaling is crucial for the development of organisms and the maintenance of tissue homeostasis, as WNT messengers are involved in a variety of cellular functions. In skeletal muscle, for example, they can increase muscle mass and improve regeneration. Wnt signaling plays a crucial role during the development and…

[maespri]

your turn to die characters ranked by how painful their death was (and why)

okay. crazy title, i KNOW. but this was actually so interesting to talk and think about. at least for me.

spoilers ahead, and TRIGGER WARNING. this post is going to go into detail about each death. it’s going to get gory and upsetting. if you don’t think you can handle hearing about that, please keep scrolling!

everything is under the cut, because this post is LONG, i'm warning you now.

some backstory: i have a special interest in anatomy and physiology, and i've always thought about how the different deaths in your turn to die worked. my wonderful friend @lovivelle and i talked about this topic extensively last night and they made this tier list with me! so, here's the ranking and explanations!

this ranking ONLY covers HUMAN deaths, because dolls/dummies do not feel pain.

quick glossary: exsanguination: death caused by bleeding out hemorrhaging: bleeding necrosis: cell/tissue death hypoxia: inadequate oxygen supply hypovolemic: loss of fluid in the body, often referring to blood or water shock: life-threatening condition where the body does not have enough blood circulating through it crush syndrome: medical condition where skeletal muscle is crushed for a prolonged time, resulting in shock and organ failure hematemesis: vomiting up blood hemoptysis: coughing up blood TBI: traumatic brain injury immolation: death by burning; being burned alive

the tier list:

OUCH!! (most painful):

nao: nao's death involves her ribcage being crushed. i put her at number one for what i hope are obvious reasons. for starters, her death is drawn-out, making the pain last even longer. while her ribcage is being crushed, any internal organs are being crushed as well. her bones are probably splintering and breaking off and piercing her insides and organs. overall... just horrible pain. official cause of death: internal hemorrhaging and irreparable damage to organs.

kurumada: kurumada's death involved being crushed (between two walls), which is similar to nao's. i would put their pain levels as being equal to each other, but kurumada's has the potential to have been less painful than nao's, because we don't know how quickly the walls crushed his body. if they were moving slowly, the pain would've been drawn-out and agonizing, and in that case, i would make the argument that his death was more painful than nao's. but if it was very quick, he would've just felt blinding pain in his entire body for a few seconds before it would end. we do have to keep in mind that kurumada is clearly quite muscular however, which probably provided some resistance against the walls, but only served to draw out his pain even further. official cause of death: muscle necrosis, internal hemorrhaging, and irreparable damage to internal organs due to crush syndrome.

either way, both definitely experienced, in my opinion, the most painful deaths in the game.

YOWZA! (very painful):

mishima: mishima's death results from his collar slowly heating up and burning his neck until his head disconnects from it. i don't even have the words to describe how painful this would be. the fact that the collar heats up slowly and it is drawn out only makes it worse. if you've ever burned yourself before anywhere on your body, you know how painful it is. imagine that pain centralized around your neck. mishima might have the fortune of his nerves being burned off after a certain amount of time, which would mean he wouldn't feel anything (think third-degree burns burning through to muscle, tissue, and nerve endings). but at that point, because the burning is around his neck and your neck contains- A) your spine/spinal cord and B) your trachea, which allows you to breathe- anyway and burning it in half would definitely kill you, he may be dead before he even has time to not feel any pain. either way, this shit would hurt so bad. official cause of death: cerebral hypoxia due to decapitation.

hinako: hinako technically has two deaths, but we ranked her based off of her being drilled. a lot of questions actually arose when my friend and i were talking about the drill deaths, because we don't know the speed at which the drills move. i mean, whether they're moving quickly or slowly, it would still obviously hurt- but the faster the drill, the quicker the death, which would make it less painful. being drilled would be unbearably painful for the sole fact that she might be alive for a lot of the drilling until it reaches any vital organs. no matter what, it'd be very painful. official cause of death: hard to say for certain, but would most likely be from exsanguination... y'know, from her body being split in half by a giant drill.

kugie (kanna's sister): my friend and i were FLOORED when we looked into kugie's death. in the game, i don't think we get a canonical answer specifically as to how she dies, but in the manga, we do. kugie and kanna have the same first trial as joe and sara, but they don't succeed. in it, kugie's bed literally snaps and essentially folds her in half. in the image from the manga, we can see blood flying out from the bed (implying it happened very quickly, because if it were slow, the blood would instead drip and flow), and kugie's hand sticking out between the two slabs of the bed. i think this death is the most painful out of the entire "YOWZA!" category because kugie was probably alive and in immense pain for at least a few seconds or even minutes after the bed snapped. if i had to speculate official cause(s) of death:

i would guess her lumbar vertebrae (basically the bottom discs of the spine) and spinal cord snapped, cutting off sensation and sending her into shock.

if she was folded in half, her legs would have quickly shot up, meaning her torso was likely unnaturally slammed into by both them and the bed, and sustained massive trauma. this would cause internal hemorrhaging and damage to her organs.

the blood spurting out of the bed was likely from her head. i'm a teenage girl, likely the same height or around the same height as kugie, and when i bend in half, my face is level with my knees. knowing this, her knees probably slammed into her face and broke her skull, causing a TBI.

the combination of all of that would have first caused terrible pain for, like i said, at least a few seconds or minutes- we don't see how extensive the damage really was, so i can't say for certain... but yeah.

aughhh (painful):

joe: joe's death is really interesting to think about, because upon first glance, you might think it's one of the most painful- but there are a few things i considered with him. his death is a result of wrigglers draining the blood out of his body. because we don't know how large the wrigglers are, i can't say how painful it would be when they enter his body- but i'd have to guess they're on the smaller side, like little tubes, because if they were big, they would have difficulty sucking out his blood due to how small blood vessels are. it would hurt horribly to have the wrigglers enter his body and drain the blood. we don't know if they moved around through his blood vessels- if they did, that would definitely exacerbate the pain- or if it was more just like getting blood drawn. but what i considered with him, the thing that makes his death less painful than the others, is the fact that he would probably pass out long before he's even fully dead. the amount of blood he's losing at such a rapid pace would first make him dizzy and disoriented before he just... passes out. his entire body would start shutting down very quickly and he wouldn't even be awake for it. his body would give up on transporting blood to the extremities and non-vital organs and shift only to transporting what little blood it can to keep vital organs running. when that blood runs out, the heart will stop being able to pump enough blood throughout the body and to the brain, and joe would actually be dead. so... yeah. official cause of death: hypovolemic shock resulting in organ failure.

shin: shin dies after being fatally injured by the death game's security system. while it's unclear exactly how the security system killed him, i believe he was stabbed/impaled somehow. there are a few questions regarding exactly where he was stabbed, but i assume he was hit somewhere in the torso because he has blood coming out of his mouth. if you don't know:

blood coming out of the mouth can be a result of haematemesis (vomiting up blood), which is where blood wells up in the stomach/digestive tract due to trauma in that area

it can also be a result of haemoptosis (coughing up blood), which results from being stabbed in the lungs/trachea due to trauma in that area

my guess is he was stabbed in the stomach, because if he were stabbed in the lungs, he'd be coughing and frothing at the mouth struggling to breathe. if i'm remembering correctly, he's also shown to be clutching his abdomen after turning on the joe AI, so... my money is definitely in the stomach.

which, you guessed it, would hurt. a lot. and there's no workaround. he's strong enough to drag himself to the rubble room and turn on an AI before dying. he would've been in blinding pain that entire time before dying.

official cause of death: exsanguination.

reko: reko technically has three canonical deaths, which made her hard to rank. i'll cover them all.

strangulation (hanging by collar): being hung is painful, but i think people underestimate how terrifying it is too. reko would have been terrified and in immense pain for a few minutes before dying. everything in her neck would be getting crushed and pressed on by the collar thanks to gravity. overall... awful death. official cause of death: cerebral hypoxia due to strangulation.

stabbed: same as what i said for shin. terrible pain for however long until she ultimately bleeds out. official cause of death: exsanguination.

fake-reko falling headfirst onto a spike: this one's... interesting! mainly because i think she would actually just be dead instantly. if the spike pierces her brain, she won't even really have time to process "ow!" before just. being dead. official cause of death: severe TBI resulting in death.

owie (painful, but not as painful as others):

q-taro: q-taro is stabbed in the back by mai and slowly bleeds to death over the course of the chapter. the reason i put him so low is because he would definitely be in some pain, but i don't think mai stabbed him very well (no offense girl). he's able to walk around, talk, and do stuff with the others after being stabbed, at least for a little while. it's difficult for me to pinpoint what exactly killed him because of this. i'd imagine his body began repairing the stab wound in his back, but ultimately, blood loss and the disruption to everything surrounding his spine (because mai stabs him in the back) is probably what killed him. depending on how deep mai's knife was, the blade may have even pierced or grazed internal organs such as q-taro's heart or a lung. his body probably put most of its focus on keeping his internal organs running whilst simultaneously trying to repair them, which tired him out over the course of the chapter, before it ultimately couldn't keep up with the amount of blood being lost. a hasty bandaging job using an office first-aid kit is not ideal for stab wounds.

*edit: this person corrected me regarding q-taro's death! i still think the severity of his injury could have killed him before the coffin cremation system actually killed him, plus the information is interesting, so i'm keeping it. but technically, being burned alive is actually what killed him. ouch.

official cause of death: exsanguination OR immolation.

kai: kai's death is kind of up in the air in terms of the specifics, but we know he kills himself during the first main game by cutting his arms. in order for this to kill him, and for him to have bled out as fast as he did, he likely cut his axillary and/or brachial artery. your brachial artery runs down the front of your bicep and is an extension of your axillary artery, which is in your upper arm/armpit. if kai cut deeply into both his brachial arteries, and/or his axillary arteries, he would bleed to death very quickly. it would be really painful, but i think adrenaline and the probability he'd pass out immediately would certainly be on his side here, making it at least a little less painful. either way, he dies quite fast, so. official cause of death: exsanguination.

uncertain (i'm not sure!):

this category is for the characters who have one or more variables that make it difficult or impossible to determine how painful their death was.

kanna: first of all, the way kanna dies is impossible in real life. lets just get that out of the way. you cannot have flowers sprout out of your body. that immediately makes it impossible to tell how painful it would be for her.

if i were to suspend my disbelief for this, however, here's what i have to say about it:

safalin says kanna is numb during her death, which would instantly give her a pain rating of zero. kanna is screaming during her death, but given what safalin says, that doesn't necessarily prove she's in pain. she could just be screaming out of fear.

if she weren't numb, yeah, she would be in a lot of pain. flowers and vines growing out of your body, poking out of your skin, running through your insides- that would hurt insanely bad.

but the fact that:

this death isn't possible in real life

kanna is presumably numb during her death

we don't specifically know how the seeds are working/moving inside her body

kind of made it impossible to rank her.

if i had to guess a cause of death, i'd guess severe disruption by the vines to her internal organs and processes is what ultimately killed her.

hayasaka: hayasaka's head is presumably cut off by a swinging axe. there are two reasons we put him in 'uncertain'; we don't know how sharp the blade of the axe is, and we don't know the velocity it's swinging at.

if the blade is swinging slowly and is very dull, it would take a few swings to fully cut off hayasaka's head, which would make it incredibly painful.

but if the blade is swinging very quickly and is super sharp, his death would be instantaneous, making it essentially painless.

so it's difficult to say, but either way:

official cause of death: decapitation.

ranmaru: ranmaru's death is in 'uncertain' because we

don't know exactly how that happened to his stomach

hear him talk about how he's numb to it

don't know how long he's been sitting there

i imagine he was in some pain and just putting up a front, but we just don't know for sure. and like i just said, we don't know what specifically killed him or how. we just see a wound in his stomach.

probable cause of death: exsanguination/hemorrhaging.

anzu: anzu's was between 'uncertain' and 'so quick.' we see spikes piercing her body, but the angle makes it difficult to tell exactly where they pierce, or how sharp they are, etc. if the spikes didn't hit her face/brain, she probably felt intense pain for some time from the neck-down before rapidly bleeding to death. if the spikes got her head, she'd die instantly. so.

probable cause of death: exsanguination? TBI? damage to internal organs/processes?

ranger: according to ranger's wiki, his human form was stabbed by an assassin. not nearly enough information to rank him with certainty.

cause of death: stabbed?

so quick (too fast to be painful):

both mai and alice's deaths were so fast, they fell into this category.

mai: mai shoots herself in the head. her death would have been immediate and painless since she shot herself in the brain.

official cause of death: fatal TBI.

alice: alice's abdomen explodes. if that happens, you're probably going to feel a very brief flash of pain before immediately dying, because the damage would be so extensive (shrapnel exploded his stomach, but there was undoubtedly collateral damage to his heart, lungs, and other organs around there). he would have been in shock if he did somehow manage to survive for a few more seconds. pain would be minimal or nonexistent in my opinion due to the sheer severity of the injury. and in terms of him being hung in chapter 3, it's the same as reko.

official cause of death: shock resulting from traumatic abdominal injury.

thats it!

if you for god knows what reason read all this, thank you! i'm honestly only posting it kind of for myself and my friend to look back on if i ever want to think about it again, but maybe someone will find it interesting.

questions, comments, concerns (of which i'm sure there are many)- i'm an open book. i'm not a professional by any means, but i am insane. bye!

[transgenderer]

The crocodile icefish or white-blooded fish comprise a family (Channichthyidae) of notothenioidfish found in the Southern Ocean around Antarctica. They are the only known vertebrates to lack hemoglobin in their blood as adults.[2]

Although they do not manufacture hemoglobin, remnants of hemoglobin genes can be found in their genome. The hemoglobin protein is made of two subunits (alpha and beta). In 15 of the 16 icefish species, the beta subunit gene has been completely deleted and the alpha subunit gene has been partially deleted.[13] One icefish species, Neopagetopsis ionah, has a more complete, but still nonfunctional, hemoglobin gene.[14]

Red blood cells (RBCs) are usually absent, and if present, are rare and defunct.[15] Oxygen is dissolved in the plasma and transported throughout the body without the hemoglobin protein. The fish can live without hemoglobin via low metabolic rates and the high solubility of oxygen in water at the low temperatures of their environment (the solubility of a gas tends to increase as temperature decreases).[2] However, the oxygen-carrying capacity of icefish blood is less than 10% that of their relatives with hemoglobin.[16]

Myoglobin, the oxygen-binding protein used in muscles, is absent from all icefish skeletal muscles. In 10 species, myoglobin is found in the heart muscle, specifically ventricles.[17] Loss of myoglobin gene expression in icefish heart ventricles has occurred at least four separate times.[2][18]

To compensate for the absence of hemoglobin, icefish have larger blood vessels (including capillaries), greater blood volumes (four-fold those of other fish), larger hearts, and greater cardiac outputs (five-fold greater) compared to other fish.[2] Their hearts lack coronary arteries, and the ventricle muscles are very spongy, enabling them to absorb oxygen directly from the blood they pump.[19] Their hearts, large blood vessels and low-viscosity (RBC-free) blood are specialized to carry out very high flow rates at low pressures.[20] This helps to reduce the problems caused by the lack of hemoglobin.

The Southern Ocean is an atypical environment. To begin with, the Southern Ocean has been characterized by extremely cold but stable temperatures for the past 10-14 million years.[26] These cold temperatures, which allow for higher water oxygen content, combined with a high degree of vertical mixing in these waters, means oxygen availability in Antarctic waters is unusually high. The loss of hemoglobin and myoglobin would have negative consequences in warmer environments.[12] The stability in temperature is also "lucky", as strong fluctuations in temperature would create a more stressful environment that would likely weed out individuals with deleterious mutations. Although most research suggests that the loss of hemoglobin in icefish was a neutral or maladaptive trait that arose due to a random evolutionary event,[27] some researchers have also suggested that the loss of hemoglobin might be tied to a necessary adaptation for the icefish.[27] Most animals require iron for hemoglobin production, and iron is often limited in ocean environments.[28] Through hemoglobin loss, icefish may minimize their iron requirements. This minimization could have aided the icefish survival 8.5 million years ago when Arctic diversity plummeted dramatically.[27]

???

[heartfullofleeches]

Clown Reader and the monster yan scientist introduced to their show to teach it about the world -

You enter the dimly lit patted cell with your hands against the wall as the metal door slams shut behind you. The stale air is pungent - acidic. Your nails chip at wearing paint as they scrape along the crevices in the walls as you stumble through the dark, tripping over your own signed merch and what you will yourself to believe are plastic dolls. The sole source of light in the room emits from a television in its far right corner. Matted hair and skeletal fingers obscure the familiar vibrant set on display - your own, chipper voice reverberating throughout the hollow prison.

"Now, I want you to close your eyes, wrap your arms around your chest, and give a biiiig squeeze. That's me, hugging you! - until next time. See you soon!"

The hands peel away from the tv with a wet sliick! as the arms attached fall around its shadowed frame. A tiny doll rests nestled in the crook of its elbow as the shadow rasps and coos in delight - lengthy, slime drenched ashen tongue patting the toy's rosy cheek. The teeth embedded into the muscle flattened againat the doll's face as it drags across - retracting into the grey flesh and leaving the plush exterior unscathed. You step back; beady, sunken eyes darting in your direction as your foot lands on the voicebox stitched into the stomach of one of your dolls.

"Cuddle me!"

The shadow drops to all four, cradling the arm with your doll to its chest. You soon realize it's number of limbs was double by three as five hands find perch on parts of your body. A growl rumbles in its throat and through your teeth, but as its jaws draw towards your neck it stops to sniff your skin. The creature looks between you and the doll in its hand, chittering softly as its eyes switch between the mini you and the real thing. You crack a smile, blinking tears from your eyes.

"H-hey, big guy! My friends out there tell me you're a fan, and from the looks of you, you might be the biggest! What's your name?"

The creatures hisses return with vengeance at the mention of others, but break into gentle purrs at the acknowledgment of being your greatest fan. It lets you go, searching around and plucking something off the breast pocket of one of those dolls you saw earlier. It licks the rectangle clean of the viscous fluid staining its frontside. It shoves the nametag in your face, tapping its claws against the plastic.

"Kevin? Your name is Kevin?"

The creature coos again, nodding its head before dipping in to sweep its tongue cross your cheek. Your smile becomes a little more genuine as you wipe your face on your sleeve. You extend your arms as it drops the doll and holds out theirs. "It's nice to meet you, Kevin."

Crackposts because yes:

Clown Reader, pointing at the scientists hiding behind thick glass: Kevin, can you tell me who this is?

Kevin, growling: Sinclair....

Clown Reader: Right! [Points at themselves] Who am I?

Kevin: Spouse.

Clown Reader: It's Y/n, actually

Kevin: Mine.

Clown Reader: Y/n

Kevin: Love.

-

Clown Reader: Ok, gang! Hope you're all ready to meet the new member to our crew.

Clown Reader, walks back stage and pulls a paper mask over Kevin's head: Alright, Kev! This is your first show. If you be good, we can do all tons of stuff together. Remember our number one rule?

Kevin: No biting. No scratching. No eating. Smile and wave

Clown Reader: Wonderful! Well, we can't keep them waiting any longer

[Clown Reader leads Kevin outside who immediately side eyes a literal puppet, pointing at its sockets before pointing down at it. The puppet silently sinks below the table.]

[dathomirdumpsterfire]

For fun, I wanted to think through which organs Darth Maul is actually missing. This gives us clues as to which bodily processes he just doesn't have anymore, which ones he's using sith juju to make up for, and what Talzin or Death Watch might've done for him with the prosthetics. To be fair, humans have about 70 to 80 possible organs systems (don't ask), but who knows what zabrak have, and where they truly are located. We can only guess.

✓ Means he probably has this.

X Means he probably doesn't have this.

O Means he probably only has some.

(Checklist and conclusions below the cut.)

✓ Adrenal glands (above the kidneys)

X Anus

X Appendix

X Bladder

O Bones

O Bone marrow (spongy part of the bone)

✓ Brain

✓ Bronchi (tubes in the lungs)

✓ Diaphragm (muscle of breathing)

✓ Ears

✓ Esophagus

✓ Eyes

✓ Gallbladder

X Genitals

✓ Heart ( 2 of them!)

✓ Hypothalamus (in the brain)

O Joints

✓ Kidneys

O Large intestine

✓ Larynx (voice box)

✓ Liver

✓ Lungs

O Lymph nodes

O Mesentery (Nerves, vessel, & fat storage in gut)

✓ Mouth

✓ Nasal cavity

✓ Nose

✓ Pancreas (hormones/enzymes)

✓ Pineal gland (in the brain- hormone production)

✓ Parathyroid glands (hormones, in the neck)

✓ Pharynx (back of the throat)

✓ Pituitary gland (in the brain, hormones)

X Prostate

X Rectum

✓ Salivary glands

O Skeletal muscles

O Skin

O Small intestine

O Spinal cord

✓ Spleen (big blood filter)

✓ Stomach

✓ Teeth

✓ Thymus gland (immune training, in the chest)

✓ Thyroid (hormones, in the neck)

✓ Trachea

✓ Tongue

O Ureters (Kidney to bladder tubes)

X Urethra

O Ligaments (connect muscles to bones)

O Tendons (connect bones to bones)

✓ Blood cells

✓ Hair (Uhhh... horns? I guess he has eyelashes?)

✓ The vestibular system (of the ear)

X Testes (unless zabrak locate them internally)

✓ Nails

X Vas deferens (testes to genitals tube)

X Seminal vesicles (semen fluid production)

X Bulbourethral glands (makes preejaculate)

X Penis

X Scrotum (if zabrak keep the testes externally)

✓ Parathyroid glands (neck, hormonal)

O Thoracic ducts (Where lymph flows into veins)

O Arteries

O Veins

O Capillaries

O Lymphatic vessels

✓ Tonsils

O Nerves

O Subcutaneous tissue

O Olfactory epithelium (nose)

✓ Cerebellum

Long story short, besides just his legs and genitals, Maul lost most of his digestive and urinary systems.

He actually kept almost all of his life-critical organs, so whatever sith voodoo he was doing to stay alive on Lotho Minor was probably focused on fighting off sepsis (due to the unclean end points of his digestive system. Remember he got cauterized by a lightsaber so assume he had to make... new holes. There may have also been some self-done surgery to reconnect what remained of his large and small intestines.)

The loss of his testes, if he indeed had human typical location for them, could have proven a growing problem, considering that they make 90% of a man's testosterone, and that's needed just to have normal amounts of energy.

The digestive track is also a problem, as the gut microbiome is where a lot of neurochemicals are produced. For example, 95%~ of the body's seratonin is produced in the gut. Lacking huge chunks of his small and large intestine means that Maul had poor absorbtion of nutrients, and probably needed to eat all the time just to get a fraction of the calories and nutrients from his food.

So. He lived on the edge of starvation due to a truncated digestive track, had low energy, mood imbalances like you wouldn't believe, and constant sepsis. I'm sure the acid rain being the only source of fresh water was also just, so helpful.

I assume, by the lack of black veins on him afterward, and (sort of?) stable mood, that talzin might've regrown some of his gut and fixed the end point issues. Later on, Death Watch (being mandalorians) might've given him more robust life support systems that included testosterone replacement and cybernetic genitals. Seems like what they would do for their own people.

Possible lingering complications? I assume he has a VERY weird relationship with food. He had spider legs for twelve years, so bipedal motion probably fails him sometimes. Back pain. Phantom leg pain. Nerve junction issues. Immune system weirdness (from all that missing marrow, and a long stint with sepsis). Issues storing fat. Talzin yoloed his brain back to sane-adjacent, so mental health is... I mean. Yeah. Triggers. Teeth prone to chipping and cavities (from malnutrition and acid water). Possibly goes to the bathroom once a day and urinates like a race horse. Issues with being touched, myriad phobias, and a squirrelly libido.

Did I miss anything?

[glocksglory]

#sxiestbackeva

_ You have a slim, tiny, feminine back that curves in, resulting in a form that resembles a gorgeous hourglass shape. The sides of your back are so concave and curve inward so prettily. You have a concave, cinched, slim, dainty, snatched, toned, feminine, victorian corset-like, winx-like, worryingly thin, malnourished-appearing, tiny, microscopic, sexy, tantalizing, hypnotizing, admirable, aggressively small waist and back. You have a waist and back that is extremely and significantly slim, slender, feminine, cinched, skeletal, lengthened, defined, hourglass-shaped, tiny, toned, concave, and curvy; there’s no denying it! Your back always appears tiny, narrow, and small in-width from any angle and any lighting. You are completely immune to love handles, muffin tops or back rolls no matter what you eat! You have an extremely visible slim, tiny, and pretty back that shows when you wear shape-hugging, open-back clothing and crop tops. You have a highly sexy, contoured, and defined back. Your back is so tiny, defined, and slim that it looks like you’ve worn the tightest professionally tailored corsets for 1111 years.

_All the fat cells from your back have been beautifully transferred to your hips, butt, and thighs. Your ribcage shows from the back with every movement because of how fatless and fat-free your back is. Your back bone structure and spine is so easily visible because of how little fat you possess on your back. You are permanently free of having any fat distributed to your back no matter what you eat, You literally have no back fat, it’s actually crazy. How’s ts even possible? You have zero fat on your upper back, mid back, and lower back. You never have any back rolls no matter what position and/or angle your back is in. It is impossible for you to ever gain fat on your back because your body simply doesn’t distribute fat there. You’re immune to being called “big-backed” in its literal definition.

_Your back is graceful and elegant, its curvature like a gentle wave that beckons one to marvel at the beauty and harmony of nature. Your back skin is smooth and clear curving gracefully around your back, showcasing a flawless back profile. Every aspect of your back's perfect proportion, harmony, symmetry and balance is a sight to behold. Every line, ever contour, and every angle of your back is perfect. Your back is like the finest silk, gliding sinuously with each graceful curve and subtle movement. Each twist and turn of your back is enticing and alluring. Like a river, sweeping across the plains of a verdant valley, you glide smoothly and effortlessly. Every movement is a symphony of fluidity and grace. Your back is a work of art; your smooth curves and soft lines blending into an exquisite tapestry of feminine elegance. The silhouette of your back is elegant and sensual. Your curves and lines evoke a sense of grace and beauty, as if captured in a painting. Your back is sleek yet alluring, a sight to provoke and captivate.

_You look so good from the back, it’s insane. Your back profile and silhouette is so captivating and screams “fuck me”. Mfs wanna fuck you from the back so bad because of how mf sexy your back looks. Really got these mfs fantasizing about how it would be beating your shit from the back. Such a pornographic back that's laced with seduction. You could arch your back so deep while laying down. 90 degrees ain’t even nothing forreal! You a whole contortionist in this bih! You have a sexy, perfect back arch. Your back remains arched while receiving backshots no matter what and people describe your back arch as the best they’ve ever seen, just like a cat.

_You possess an extremely inhumane flexible back like wtf… it can twist and turn in any direction. So much so that you are able to perform back walkovers, scorpions, back bends, bridges, and back handsprings with ease. You're able to hyperextend your muscles, joints, and soft tissues in your back with no pain or harm whatsoever. You have amazing spinal flexibility, mobility, and fluidity with a wide range of motion. Further prompting you to easily move your back side to side, or forward and backward. Your spine is flexible and can bend and stretch without any tension or pain. The muscles, joints, and soft tissues in your back are elastic and strong. You have healthy ligaments, joints, muscles, fascia, tendons and fibrous tissues. Your spine is like that of a snake, gliding effortlessly.

_You have a completely healthy and aligned spine. All of your intervertebral discs, the joints, muscles, bones, vertebrae and nerves in your back are perfectly healthy, position, and support your spine perfectly. You have a healthy spine that is medically in perfect shape. You have the best posture known to mankind. You have elegant, beautiful, straight, perfect, fixed, attractive, feminine, alluring, appealing body posture. You have a mathematically perfect lumbar curve. You have perfectly aligned neck joints, shoulders and knees. The disks, joints, soft tissues, nerves and your spinal cord are perfectly healthy. You always have a tall & straight posture while sitting, standing and walking. You exude irresistible confidence while walking and doing anything honestly. You always have the perfect posture for standing, sleeping, sitting, walking, and swimming. You're always standing up straight and tall. Your shoulders are always relaxed and rolled back. Your belly is always pulled in.

_You have deep back dimples in your desired placement, shape, size, and depth. Your back dimples are scientifically and genetically symmetrical, balanced, proportional, and harmonical in shape, size, position and depth. Everything about your back dimples is so sexy and exactly how you desire. Your back dimples are so gorgeously pronounced and eye catching. Everything you do is an automatic stimulus to make your back dimples more accentuated, defined, and prominent.

_You have an extremely defined deep backline. Your back line is so gorgeously pronounced and eye-catching. Everything you do is an automatic stimulus to make your backline more accentuated, defined, and prominent. Your back line is visible from up close or far away. Your erector spinae is so strong, further accentuating your deep backline. Your erector spinae is so defined, well-built and prominent.

& affs for the sides of your waist/abdomen to simultaneously get narrower with your back.

back anatomy & other reference pics

[mindblowingscience]

Scientists have successfully induced rhabdomyosarcoma cells to transform into normal, healthy muscle cells. It's a breakthrough that could see the development of new therapies for the cruel disease, and it could lead to similar breakthroughs for other types of human cancers. "The cells literally turn into muscle," says molecular biologist Christopher Vakoc of Cold Spring Harbor Laboratory. "The tumor loses all cancer attributes. They're switching from a cell that just wants to make more of itself to cells devoted to contraction. Because all its energy and resources are now devoted to contraction, it can't go back to this multiplying state." Cancer isn't a monolithic thing. It arises when cells from different parts of the body mutate. Rhabdomyosarcoma is a type of cancer that's most often seen in children and adolescents. It usually starts in the skeletal muscle when cells therein mutate and start multiplying and taking over the body.

Continue Reading

[vorecaptions]

Metamorphosis part 1

Aaron's father have been grumpy about his age, how his body was getting weaker and not doing as good as before. 

God, that was so fucking annoying having to hear him nagging all day long of how incredible he was at his best. I had no patience to hear anymore of that shit, so I proposed a really absurd idea, he could become one of the subjects of my PhD research on pred's genetics. My family bloodline had not a single predator gene in it so I started making papers to understand how a pred could become one or pass it to their offspring. My research showed that preds genes were highly volatile, making their bodies capable of the most absurd adaptations and, because of it, in need of humongous amount of nutrients to fuel it. Because of this insane genetic adaptability I pondered to be possible to introduce it via transplant of a few cells into a standard man and, in theory, the cells to be able to entangle the genetic structure from host and donor much alike some preds absorb their prey instead of digestion. To do a test however I need a subject willing to risk everything, even this days genetic engineering was a shot in the dark. His father didn't need to be told twice to agree head on.

-

The treatment was not so much complex as one would think. All he need to do was getting a sample of preds cells and inject them in the hosts body. Aaron explained that since the risk of unforeseen shenanigans was high they would need to pick an "expendable bit" of his body, one that wouldn't involve too much structural muscle skeletal changes. The locale has been obvious, they would need to use his penis. His dad was reluctant, but agreed saying he didn't use that "shriveled piece of meat in years". The preds cells were from a young donor, a teen yet to have his first feeding. This characteristic was crucial, everything a pred would feed he would also assimilate bits of his preys dna, making his own genetic makeup more unstable in long runs, making them feed more and more to stabilize it as they get older. A small prick on his dad meat and one in each of his small nuts was enough to finish the operation. Now was the waiting game. Two weeks past it, and constant checkups indicated a good integration on both the genetic makeups. Aaron noticed the skin of his dad cock wad getting darker, he recalled the donor was a black teen, perhaps it has influenced throughout the dna intermingle of host and donor cells. The tissues of the genital area did look more tender and firm, the testicles were more round and scans confirmed their changes, they soon demanded nourishment... The rate of development was way quicker than Aaron would've predicted, and it did scare him. He soon realized the quimeric cells made from his experiment would propagate to the rest of the host body. A month later and his dad had been different already, he had way less wrinkles and would talk about how his nuts were churning seminal fluid nonstop. This last bit was expected, the treatment made his cells unstable as a pred, albeit as much as an inexperienced one after his first meals. His father would need constant new genetic mass to surplus his own degrading dna. The problem however was obvious, his dad was not a pred, he did not have their innate biological capacity of swallowing or directly absorbing his preys. That came with yet another conundrum. How in the actual fuck would he solve this problem? Getting dna for him would become a problem, if he gave another genetic makeup it would desistabilize his matrix even more and larges quantities would be required. This situation Aaron resolved fairly easy, he would donor his own dna to his father, since he was made from his seed his genetic makeups were more similar than any. The first "meal" wad quite weird. Aaron could've had done it with any bit of himself, hair, skin, blood. He decided to make his donation with his seed as well, it made sense to him since the central point of the transformation his father had came directly from his genitals, the sperm cells would be much easier recognized.

With a syringe without needle filled with his cum, he inserted in the urethra of his dad eager cock. The thing was hard as steel and Aaron could just see the slit gaping as if it was trying swallow the upper point of the syringe. Slowly he injected the stuff down the schlong, it really looked like gulping its contents, he could see the small bulge following the underside of his dad dick all to the base.

-please son, it was so fucking good, don't more...

His dad looked like a dumb gooner during a edge session, his face in ectasy and his tongue out like a fucking perv.

His administration of dna did wonders to his dad. He looked way livier and showed improved health on his exams. It did however show something unexpected. His father celular degradation slowed down considerably, but by just one exposition to new dna shouldn't have this effect. Only about weeks later would he actually discover what was happening.

By accident would Aaron have checked one of the ip cams he had on his home, the thing malfunction made him have to reinstall the necessary apps for it to work. Curiosity called him to check how weird he'd sound while snoring, that's when he witnessed something that would change everything about his experiment.

His father entered the room while Aaron was passed out snoring. Gently his old man unfurled him from his blankets. His dad would often stay still, frozen when he moved a bit, he was trying really hard to not wake him. When he saw it was safe enough he slowly put his hand inside his sons boxers and took the soft penis out. He took his time looking at the meat. Weighing it in his large hand before he would take his own schlong from his underwear. Through the cam Aaron was astonished about what was happening but the next thing was way off the scale. His dad dick was fattening, engorging as it got hard. It didn't look full hard though, as if a half mast, still flexible. Dad studied his own dick for a bit before he got closer to Aaron. He proceeded to rub his fat gland against his son soft cockhead. It was then that he bit his own hand, like trying to block any sound coming from his mouth and leaning a bit to the side that Aaron could see what he was doing. The fat cock was even more fat, thick, because it was engulfing his own, it was like a snake swallowing another! It was way beyond mere docking with their foreskin, his dick was being devoured by his dad own schlong! God, it was so absurd, and he could even see the thing making sucking, slurping motions as if trying to get more of his meat. Aaron did not know what was happening, but he could see it was affecting his dad, his face strained, eyes closed and his mouth still locked bitting his hand. Few minutes later he saw his cock, now hard, getting even harder against the other engulfing it, his balls retracted and he ejaculated. A soft moan was heard, his dad couldn't control it anymore, the seed his son spurt was injected directly into him through his urethra, his cock was slurping all the contents his balls churned that night, his own testicles were so hungry and he needed something to fill their emptiness.

His dad would not leave until every spurt was drained by his cock, until his victim deflated and dislodged from his pisslit. He would massage his balls and put a face as if tasting something delicious.

Aaron was beyond shocked, but confused as well. He was a heavy sleeper but not enough to have his meat raped and not waking up. Reviewing the records he realized his dad had been doing it for a week.

[bpod-bpod]

Mutations at Heart

Filamin C protein is key for maintaining the internal structure of both heart and skeletal muscle cells. This study reveals mutations in the filamin C gene and their molecular effects underlying cardiomyopathies

Read the published research article here

Image from work by ES Klimenko and colleagues

Almazov National Medical Research Centre, Institute of Molecular Biology and Genetics, Saint-Petersburg, Russia

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Cytoskeleton, September 2024

You can also follow BPoD on Instagram, Twitter and Facebook

[rachellaurengray]

Hey everyone!

I’m excited to share this comprehensive list of essential minerals and their roles in our bodies. As many of you know, understanding the function of each mineral can be incredibly empowering for maintaining our health and well-being. From supporting bone strength to aiding in energy production and immune function, each mineral plays a unique and crucial role.

This list not only highlights the importance of these minerals but also serves as a handy reference for anyone interested in optimizing their diet and health. Whether you’re a health enthusiast, someone looking to boost their nutrition, or just curious about how your body functions, this information is invaluable.

Feel free to save this post for easy access and share it with friends who might find it helpful. Let’s make informed choices about our health together!

Here’s a rundown of some key minerals and their roles:

Boron - Supports bone health and hormone regulation.

Phosphorus - Vital for bone and teeth formation, energy production.

Manganese - Involved in metabolism, bone formation, and antioxidant function.

Iron - Essential for oxygen transport and energy production.

Calcium - Critical for bone and teeth health, muscle function, and nerve signaling.

Selenium - Acts as an antioxidant, supports immune function and thyroid health.

Sulfur - Important for amino acid synthesis and detoxification.

Sodium - Regulates fluid balance, nerve function, and muscle contraction.

Magnesium - Supports muscle and nerve function, blood glucose control, and bone health.

Potassium - Helps maintain fluid balance, nerve function, and muscle contractions.

Zinc - Crucial for immune function, protein synthesis, and wound healing.

Copper - Involved in iron metabolism, connective tissue formation, and antioxidant defense.

Iodine - Essential for thyroid hormone production and metabolism regulation.

Fluoride - Strengthens tooth enamel and supports bone health.

Chromium - Enhances insulin action and glucose metabolism.

Cobalt - Part of vitamin B12, essential for red blood cell formation.

Molybdenum - Helps with enzyme function and detoxification.

Nickel - Involved in the metabolism of fats, carbohydrates, and proteins.

Silicon - Supports bone health and connective tissue integrity.

Vanadium - Plays a role in bone health and insulin regulation.

Strontium - Supports bone health and may aid in bone density.

Lithium - May influence mood regulation and neurological health.

Calcium - Important for cardiovascular health and muscle function.

Magnesium - Helps in enzyme reactions and DNA synthesis.

Iron - Supports cognitive function and immune health.

Potassium - Essential for heart function and muscle contractions.

Zinc - Important for DNA synthesis and cell division.

Selenium - Enhances antioxidant defenses and thyroid function.

Manganese - Assists in wound healing and bone development.

Phosphorus - Aids in energy production and bone health.

Copper - Crucial for brain development and cardiovascular health.

Sodium - Regulates blood pressure and volume.

Iodine - Essential for thyroid hormone production and metabolic regulation.

Fluoride - Helps prevent dental cavities and strengthens bones.

Chromium - Supports metabolism of carbohydrates and fats.

Molybdenum - Important for enzyme activity and metabolic processes.

Nickel - Assists in the metabolism of fatty acids and hormones.

Silicon - Enhances skin health and bone strength.

Vanadium - Potentially involved in glucose metabolism and bone health.

Strontium - May contribute to bone density and overall skeletal health.

Cobalt - Key component of vitamin B12, important for nerve function.

Lithium - May have effects on mood and mental health.

Calcium - Supports cardiovascular function and muscle contraction.

Magnesium - Contributes to heart health and muscle relaxation.

Iron - Essential for energy production and oxygen transport.

Potassium - Important for maintaining electrolyte balance and cellular function.

Zinc - Aids in immune function and skin health.

Selenium - Helps protect cells from damage and supports thyroid function.

Manganese - Facilitates enzyme reactions and antioxidant defense.

Phosphorus - Integral to energy storage and bone mineralization.

Hope you find this list as enlightening as I do! Feel free to save and share.

[wheelie-sick]

What is Idiopathic Mast Cell Activation Syndrome?

Idiopathic Mast cell activation syndrome (MCAS) is one of several mast cell disorders. MCAS occurs when there are a normal number of mast cells in a person's body but they over-release mast cell mediators causing random allergic reactions in multiple systems of the body. MCAS is incredibly common being present in an estimated 17% of the population.

Symptoms

MCAS symptoms are incredibly varied and always occur in multiple systems of the body. Anaphylaxis is common.

[ID: A graphic labeled "Some common symptoms of Mast Cell Disease" A graphic of a person standing in the center with multiple organs visible is shown. Around the person are lines pointing to specific areas of the body labeled with the body system and symptoms. Clockwise these read "Neurological headache, brain fog, cognitive dysfunction, anxiety, depression Cutaneous (Skin) flushing of the face/neck/chest, hives, skin rashes, itching with or without rash Cardiovascular light-heartedness, syncope (fainting), rapid heart rate, chest pain, low blood pressure, high blood pressure at the start of a reaction, blood pressure instability Gynecological uterine cramps, bleeding Urinary bladder irritability, frequent voiding Systemic and/or organ specific Anaphylaxis angioedema (swelling) Skeletal bone/muscle pain, osteopenia, osteoporosis Gastrointestinal diarrhea, nausea, vomiting, abdominal pain, bloating, gastroesophageal reflux disease (GERD) Ear/Nose/Throat/Respiratory nasal itching and congestion, throat itching and swelling, wheezing, shortness of breath and more" In the bottom left corner "Symptoms can be sudden and unpredictable in onset learn more at tmsforacure.org"]

MCAS symptoms are specifically not allergies. the reactions may look like allergies but the two are not the same and MCAS is not a condition meaning "many allergies" While MCAS can have some consistent triggers one of the defining features of the disease is that reactions are random and happen unpredictably.

Anaphylactic shock is not a requirement for diagnosis.

Diagnosis

MCAS is diagnosed by an immunologist. It is in part a diagnosis of exclusion and requires ruling out both allergies and systemic mastocytosis as well as other conditions such as certain types of tumors.

Diagnostic criteria for MCAS is debated. Some immunologists follow the symptom-based diagnosis approach in which case the diagnostic criteria are:

Recurring and severe anaphylactic-like episodes that involve more than one organ system

and

Positive response to mast cell stabilizing or mediator medications anaphylaxis-type symptoms

Others follow diagnostic criteria based on laboratory findings. In this case the diagnostic criteria are:

Episodic symptoms consistent with mast cell mediator release affecting two or more organ systems evidenced as follows:

Skin: urticaria, angioedema, flushing

Gastrointestinal: nausea, vomiting, diarrhea, abdominal cramping

Cardiovascular: hypotensive syncope or near syncope, tachycardia

Respiratory: wheezing

Naso-ocular: conjunctival injection, pruritus, nasal stuffiness

and

A decrease in the frequency or severity; or resolution of symptoms with anti-mediator therapy: H1 and H2 histamine receptor antagonists, anti-leukotriene medications (cysLT receptor blockers or 5-LO inhibitor), or mast cell stabilizers (cromolyn sodium)

and

Evidence of an elevation in a validated urinary or serum marker of mast cell activation: Documentation of elevation of the marker above the patient’s baseline during a symptomatic period on at least two occasions; or if baseline tryptase levels are persistently >15ng, documentation of elevation of the tryptase above baseline on one occasion. Total serum tryptase is recommended as the markers of choice; less specific (also from basophils) 24 hour urine histamine metabolites, or 11-beta-prostaglandin F2.

and

Primary (clonal) and secondary disorders of mast cell activation ruled out.

These are not all proposed diagnostic criteria as the subject is heavily debated. Generally, a laboratory-confirmed MCAS diagnosis is considered more legitimate.

Treatment

MCAS is a very treatable condition. Generally treatment follows a path from antihistamines -> mast cell mediators -> biologics.

Epipens are given to MCAS patients with a history of anaphylaxis.

Antihistamines are divided into 2 categories: H1 antagonists and H2 antagonists. These categories are determined based on the histamine receptor each one targets.

H1 antagonists mostly deal with systemic and cutaneous symptoms. H1 antagonists are also further divided into first and second generation antihistamines. first generation antihistamines include diphenhydramine (Benadryl) and Hydroxyzine. These tend to cause drowsiness. With second generation H1 antagonists cause fewer side effects and include drugs like loratadine (Claritin) and cetirizine (Zyrtec)

H2 antagonists primarily affect the gastrointestinal tract and include medications like famotidine (pepcid)

Typically when treating MCAS a person will be put on both a second generation H1 antagonist and an H2 antagonist.

When antihistamines do not treat symptoms well enough the next step is a mast cell mediator. The most common mast cell mediator is cromolyn sodium which is available by prescription only. (this is technically available OTC but it is at 1/50th the dose used for MCAS) Mast cell mediators work by preventing the degranulation of mast cells in the first place.

When both antihistamines and mast cell mediators are insufficient someone with MCAS might be prescribed a biologic such as Xolair to treat their remaining symptoms.

Sources:

American Academy of Allergy, Asthma, and Immunology

Mast Cell Hope

Mast Cell Activation Syndrome: Proposed Diagnostic Criteria

[day-at-rhodes-island]

one thing i've been wondering, continually, is that if oripathy tends to spread outwards from the point of infection, why isn't amputation a viable treatment? i mean, i could see the argument that infection could remain from residual particles in organs, blood, etc, but it still seems like it would be an effective way to slow a particularly bad infection in a limb.

This actually has a fairly simple answer, oripathy doesn't spread from the point of infection.

Infection is determined by particulate concentration in the blood. You are considered infected once the levels rise to a point where ore lesions begin to form.

The infection site generally sees the development of ore lesions much faster than other areas, but this is usually due to originium particles left in the tissue during the infection event acting as nucleation sites. If you are at a point where the ore lesions start forming, that means it's in your blood, and cutting things off won't help. Even if you cut off the limb immediately, it probably isn't going to effect whether or not there are active particles already in your blood or not, so it's not going to help either.

So, surgical removal of ore lesions from non-vital organs isn't going to improve the patient's condition, and would likely just cause more damage. Ore lesions are generally benign, rarely causing more than slight issues moving when in skeletal muscle when properly treated, and rarely being the cause of death. Usually the cause of death from oripathy is multiple organ system failure caused by cascading mass cell assimilation (an oripathy flareup), which can be catalyzed by arts usage or just happen randomly.

[darkmaga-returns]

Popular weight-loss drug Ozempic is shrinking the human heart and other muscles, according to a disturbing new University of Alberta study.

According to researchers, people should be cautious about taking trendy new weight-loss drugs due to the potentially deadly side effects.

Ualberta.ca reports: “If people have been prescribed these drugs, then the benefits should likely far exceed the risks,” says Jason Dyck, lead author on the study, pediatrics professor in the Faculty of Medicine & Dentistry and a member of the Women and Children’s Health Research Institute.

“However, the growing number of people who may be taking these drugs who do not meet the eligibility criteria and who are not at risk have a different risk-reward calculation that they should be made aware of.”

Dyck and his team set out to study why a reported side-effect of the leading weight-loss drug Ozempic is the loss of skeletal muscle.

Ozempic, known medically as semaglutide, was originally designed to help adult patients with type 2 diabetes control their blood sugar. However, this drug — and a host of others in this class of medication — are also being touted for their effectiveness as an anti-obesity medication.

Using mice for the study, the researchers found that heart muscle also decreased in both obese and lean mice. The systemic effect observed in mice was then confirmed in cultured human heart cells.

Dyck, who is the Canada Research Chair in Molecular Medicine and heads up the Cardiovascular Research Centre, says his team did not observe any detrimental functional effects in hearts of mice with smaller hearts and thus would not expect any overt health effects in humans. But he adds that there may be more impact over the long term, or some forms of cardiac stress may have a detrimental effect that wasn’t observed at rest.

[humancelltournament]

Human Cell Tournament Round 2

Propaganda!

Phosphocreatine, also known as creatine phosphate, is a phosphorylated form of creatine that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle, myocardium and the brain to recycle adenosine triphosphate, the energy currency of the cell.

Lysine (Lys) is an α-amino acid that plays several roles in humans, most importantly proteinogenesis, but also in the crosslinking of collagen polypeptides, uptake of essential mineral nutrients, and in the production of carnitine, which is key in fatty acid metabolism. Due to its importance in several biological processes, a lack of lysine can lead to several disease states including defective connective tissues, impaired fatty acid metabolism, anemia, and systemic protein-energy deficiency.

[healthy-dude]

Why Blaming Carbs for Diabetes is Like Blaming Water for Drowning

Welcome to my post on why diabetes isn't just a sugary death sentence but a greasy one at that. Imagine your body is like a very finicky luxury car. You wouldn't fill its tank with maple syrup and bacon fat and expect it to run smoothly, would you? Well, your body works in a somewhat similar fashion—too much junk, especially fats, clogs up the works.

Here’s the breakdown for the medically uninitiated:

The Fat Trap: Think of saturated fat as the uninvited guest who crashes on your couch (skeletal muscles), refuses to leave, and blocks the door (prevents glucose from entering cells), causing a nasty traffic jam (elevated blood sugar).

Fructose – The Wolf in Sweet Clothing: Drinking your fructose in sodas is akin to trying to put out a fire with gasoline. It rushes in, overwhelms the system, and instead of being a quick energy source, it turns into fat. That's right, that sweet drink is more like a fat keg.

Cellular Traffic Jam: Here’s a fun fact — saturated fats cause a cellular traffic jam worse than Tokyo at rush hour. It messes up the whole energy production line, leading to increased blood sugar because glucose can’t get where it needs to go.

The Historical Angle: Historically, populations gorging on fats have shown more diabetes. Surprise, surprise. Meanwhile, high carb consumers (like the rural Chinese or Okinawans with their sweet potatoes) lived their days with hardly any diabetes. Maybe carbs aren’t the bad guys after all?

Sweeney’s 1927 Revelation: Since 1927, we've known that fats mess up insulin sensitivity. That's almost a century ago, and yet here we are, still debating whether to blame sugar or fat for diabetes.

So, what do we gather from this historic and scientific mishmash? Diabetes loves fat more than carbs. It's a lipid disease, mortals.

Advice from your not-so-friendly neighborhood nutri-student: Eat less saturated fat, dodge those sweet drinks, and maybe, just maybe, you’ll steer clear of the metabolic iceberg that diabetes really is.

Remember, when it comes to your health, sometimes the simplest advice is like Occam’s razor – cutting through the complexities to reveal a solution that’s, well, painfully obvious.

Stay healthy or, at the very least, try not to actively mess it up.