#Public relations companies in San Diego

[toppragency1]

Leading the Way Public Relations Agencies San Diego

In today's dynamic business landscape, the role of public relations (PR) agencies in San Diego has become increasingly vital. These agencies play a crucial role in shaping the public image of businesses, managing their reputations, and amplifying their brand presence through strategic communications. Whether you're a startup looking to gain visibility or an established corporation aiming to maintain a positive public perception, partnering with the right PR firm in San Diego can make all the difference.

Why PR Matters

Public relations is not just about issuing press releases or managing crises; it encompasses a wide array of activities aimed at building and maintaining mutually beneficial relationships between an organization and its stakeholders. This includes media relations, community engagement, content creation, event management, and digital PR strategies. By leveraging these tactics effectively, Public relations companies in San Diego help businesses cultivate credibility, trust, and authority in their respective industries.

PR Firms in San Diego: An Overview

San Diego, known for its vibrant business community and diverse industries ranging from biotech to tourism, hosts a variety of PR firms catering to different needs and budgets. From boutique agencies specializing in niche markets to larger firms offering comprehensive PR services, businesses here have ample choices when it comes to finding the right PR partner.

Top PR Firms in San Diego

Press Release Power

Specializing in comprehensive PR services, Press Release Power helps businesses of all sizes amplify their brand messaging through strategic media placements and targeted outreach campaigns. Known for their expertise in press release distribution and media relations, they have carved a niche for themselves in the San Diego PR landscape.

PR Wires

PR Wires stands out for its innovative approach to digital PR and reputation management. They offer tailored PR solutions that include online brand monitoring, crisis communication strategies, and social media management, making them a preferred choice among tech startups and consumer brands alike.

Best PR Firms in San Diego

When evaluating the best PR firms in San Diego, several factors come into play, including industry expertise, client success stories, and innovative PR strategies. Here are some top contenders:

Press Release Power: Known for their exceptional press release distribution services and media contacts in the San Diego area, Press Release Power has helped numerous businesses achieve significant media coverage and brand recognition.

PR Wires: Recognized for their creativity and digital-first approach, PR Wires excels in creating compelling narratives that resonate with target audiences across various digital platforms.

Services Offered by PR Agencies

Press release distribution San Diego offer a wide range of services designed to enhance brand visibility and reputation management. Some key services include:

Media Relations: Building relationships with journalists and securing media placements in prominent publications.

Content Creation: Developing engaging content such as press releases, articles, blog posts, and social media content that aligns with the client's brand voice.

Crisis Communication: Developing strategies to mitigate damage during times of crisis and manage communication with stakeholders effectively.

Event Management: Planning and executing events that enhance brand visibility and foster community engagement.

Digital PR: Utilizing digital platforms and strategies to enhance online presence and manage brand reputation in the digital space.

Choosing the Right PR Agency

Selecting the best PR agency in San Diego depends on several factors, including your business goals, budget, and the agency's expertise. Here are some tips to consider:

Define Your Goals: Determine what you aim to achieve through PR - whether it's increased brand awareness, crisis management, or launching new products/services.

Industry Expertise: Look for agencies that have experience working within your industry or niche. They will better understand your challenges and opportunities.

Track Record: Review case studies and client testimonials to gauge the agency's success in delivering results similar to what you seek.

Communication and Transparency: Ensure the agency communicates clearly and transparently about their strategies, progress, and results.

Budget: Discuss pricing structures and ensure that the services offered fit within your budgetary constraints.

Press Release Distribution in San Diego

Press release distribution remains a cornerstone of Public relations firms in San Diego. It involves disseminating newsworthy information about a business or organization to journalists, media outlets, and online platforms. Effective press release distribution can generate media coverage, drive traffic to your website, and enhance your SEO efforts.

Press Release Distribution in San Diego

Press release distribution remains a critical component of public relations strategies in San Diego. It involves disseminating newsworthy information about a business or organization to journalists, media outlets, and online platforms. Effective press release distribution can generate media coverage, drive traffic to your website, and enhance your SEO efforts.

Importance of Press Release Distribution

In the digital age, where information travels rapidly across various online channels, a well-crafted press release can serve as a powerful tool for gaining media attention and boosting brand visibility. Here’s why press release distribution is crucial for businesses in San Diego:

Media Exposure: Press releases are designed to attract the attention of journalists and media outlets. By distributing a press release through reputable distribution channels, businesses can increase their chances of getting coverage in local, national, or industry-specific publications.

SEO Benefits: Press releases can include relevant keywords and links back to your website, which can improve your search engine rankings. When distributed through online PR distribution services, they can also generate backlinks from high-authority websites, further boosting your SEO efforts.

Brand Authority: Regularly issuing press releases helps establish your business as a credible authority within your industry. Media coverage and mentions in reputable publications enhance your brand's reputation and trustworthiness among potential customers and partners.

Announcing News and Milestones: Whether you're launching a new product, opening a new office, or achieving a significant milestone, a press release allows you to share this news with a broader audience in a structured and professional manner.

Effective Press Release Distribution Strategies

To maximize the impact of your press release distribution efforts in San Diego, consider the following strategies:

Targeted Distribution: Identify media outlets, journalists, and bloggers who cover topics relevant to your industry or niche. Tailor your press release distribution list to ensure it reaches the right audience.

Engaging Content: Craft a compelling headline and lead paragraph that grabs attention and clearly communicates the newsworthiness of your announcement. Use concise language and include relevant quotes or statistics to add credibility.

Multimedia Integration: Incorporate multimedia elements such as images, infographics, or videos to enhance the appeal of your press release. Visual content can increase engagement and make your story more shareable on social media platforms.

Timing: Distribute your press release at strategic times to coincide with industry events, product launches, or seasonal trends. Consider the news cycle and avoid major holidays or competing news events that could overshadow your announcement.

Follow-Up: After distributing your press release, follow up with journalists and media contacts to gauge their interest and offer additional information or interviews. Building relationships with reporters can increase your chances of securing media coverage.

Choosing a Press Release Distribution Service

When selecting a press release distribution service in San Diego, consider factors such as:

Distribution Reach: Ensure the service has access to a wide network of journalists, bloggers, and media outlets both locally and nationally.

Reporting and Analytics: Look for services that provide detailed reports on distribution metrics, such as the number of views, clicks, and media pickups your press release receives.

Cost and Packages: Compare pricing structures and packages offered by different distribution services to find one that fits your budget and specific needs.

Reputation and Reviews: Read client testimonials and reviews to gauge the reliability and effectiveness of the distribution service in achieving results.

Public Relations Agencies in San Diego: Navigating the Landscape

In San Diego's bustling business environment, the role of public relations (PR) agencies is indispensable for companies looking to manage their reputation, enhance brand visibility, and effectively communicate with their target audiences. From innovative startups in the biotech sector to established firms in tourism and hospitality, Public relations agencies San Diego cater to a diverse range of industries, each with unique PR needs and challenges.

The Evolving Role of PR Agencies

Public relations has evolved beyond traditional media relations to encompass digital PR, social media management, influencer outreach, and content marketing. PR agencies in San Diego are at the forefront of adopting these strategies to help businesses adapt and thrive in an increasingly digital world.

PR Services Offered in San Diego

Media Relations: Establishing and nurturing relationships with journalists and media outlets to secure earned media coverage for clients.

Digital PR: Utilizing online platforms, social media, and digital content to amplify brand messaging and engage with target audiences.

Crisis Communication: Developing strategies and protocols to manage communication during crises or reputational challenges effectively.

Content Creation: Crafting compelling content such as press releases, articles, blogs, and social media posts that resonate with the target audience.

Event Management: Planning and executing events, from product launches to press conferences, to enhance brand visibility and engagement.

Choosing the Right PR Agency in San Diego

Selecting the best PR agency in San Diego involves careful consideration of several factors:

Industry Expertise: Look for agencies with experience in your industry or niche, as they will have a deeper understanding of your business environment and target audience.

Track Record: Review case studies and client testimonials to assess the agency's success in achieving measurable results for their clients.

Strategic Approach: Evaluate the agency's approach to PR, including their strategies for media relations, crisis management, and digital PR.

Communication Style: Ensure that the agency communicates clearly, listens to your goals, and provides transparent reporting on their activities and outcomes.

Leading PR Firms in San Diego

Several PR agencies stand out for their excellence in delivering impactful PR strategies tailored to the unique needs of San Diego businesses:

Press Release Power: Known for their expertise in press release distribution and media relations, Press Release Power helps businesses of all sizes garner media attention and enhance brand visibility in the competitive San Diego market.

PR Wires: Specializing in digital PR and reputation management, PR Wires excels in leveraging digital channels to create compelling narratives that resonate with audiences and drive engagement.

The Future of PR in San Diego

As technology and media landscapes continue to evolve, PR services San Diego will play a crucial role in helping businesses navigate these changes. By embracing innovative PR strategies, such as data-driven PR campaigns and immersive storytelling, agencies can help clients stay ahead of the curve and achieve their communication goals effectively.

Closure

Public relations agencies in San Diego serve as invaluable partners for businesses seeking to build and maintain strong relationships with their audiences while enhancing their brand reputation. Whether you're a local startup looking to make a splash or a global corporation aiming to strengthen your presence in the region, partnering with a reputable PR agency can provide the expertise and strategic guidance needed to succeed.

For more information on how PR agencies in San Diego can benefit your business or to explore tailored PR services, contact Press Release Power or PR Wires today. Let us help you lead the way in shaping your brand's narrative and achieving your PR objectives in San Diego's competitive marketplace.

Get in Touch

Mobile – +91-9212306116 WhatsApp – https://call.whatsapp.com/voice/9rqVJ… Skype – shalabh.mishra Telegram – shalabhmishra Email – Shalabh.web@gmailcom

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Public Relations Agencies NYC | The Sprout PR Seeking effective Public Relations Agencies in NYC? These agencies excel in media relations, crisis management, and strategic communication, enhancing public images and fostering positive audience relationships.

[lestats-ovaries]

Okay idk if this is just me being negative, but I personally get enjoyment out of the shows I watch by ripping them to shreds in the name of improvement, because there's always something there that's great, it just has to be refined and shaped to reach it's full potential. So, bear with me here.

I'm a 911 fan, and one who really enjoys the opening disasters. I have a pretty good suspension of disbelief, so usually I can deal with scientific inaccuracies and contrivances for the sake of good storytelling. I'm not the kind of person to point at the earthquake opener and be like "uhm akshually all buildings in california have to be built on a floating foundation and obey strict safety regulations to withstand earthquakes, so the high rise crumbling the way it did is actually really unrealistic." I don't mind extreme situations, as long as they're not so impossible it breaks my suspension of disbelief.

That being said, I can firmly and completely say that the bee-nado season 8 opener looks like the absolute dumbest thing you could ever write, not just because it's contrived and overly dramatic, but because it's wildly, comically unrealistic and breaks suspension of disbelief in a way that 911 has never really done before. Sure, a blimp crashing into a packed stadium is kinda dumb and contrived, but at least it's a thing that could realistically happen with a (semi) realistic aftermath.

The bee-nado is so bad it's almost insulting. Killer bees are a trope that's been beaten to death, to the point where 911's had a bee related emergency before, and from the trailer, this seems to be a depiction that's much, much worse.

(Cut for people who don't want to deal with the dissertation I wrote, which. totally fair, it's over 1300 words and arguably kinda nitpicky. dw, there's a tldr at the end)

Without further ado, my unsolicited opinion. Enjoy.

First, let's get our facts straight:

One: the "killer bees" they're talking about are most likely africanized honey bees, an artificial breed of bee first cultivated and then accidentally released in brazil, which has spread north all the way up to Texas, Florida, San Diego and LA (plus more, really any southern border state) via migration.

Two: the 22 million number they mention in the trailer is, as far as I can tell, an accurate number when it comes to transporting bees commercially. Generally this is done by companies who are hired by farmers to bring beehives to their crops for pollination; they take trucks filled with bees, covered in a mesh net to try and keep them in, and drive them down to the farmland. More on this later

Three: when in trucks, honey bees can only be transported under certain conditions. If they get too hot, they tend to fly out of their hives to avoid boiling in their exoskeletons. The main ways truck drivers mitigate this is by driving at night, waiting for a cold day/week to go, or going fast enough that the wind keeps the bees cool and inside.

Four: africanized honey bees are considered an invasive nuisance in california and aren't cultivated in large masses anywhere in the US. Nests that are found are usually destroyed because of the threat they pose to public safety, and there's even

Knowing all this, let's consider the "bee-nado."

One: there's no way anyone would be transporting 22 million cultivated africanized honey bees. No company would ever want to work with them because they're an insane liability to public health, and would get them sued so quickly if anything went wrong. See: literally the season opener. And at the same time, what private beekeeper has the money to care for 400 hives of hyperaggressive bees?

Two: The transportation issues. Like I said earlier, bees are generally transported at night/during lower temperature days because bees are less active in the cold, are less prone to suffocation/leaving the hive, and are usually taken places on highways because it means less stops where the bees can escape. So why the hell are we transporting them straight through LA, a place that's notoriously hot and has traffic for days, meaning the truck would lose a bunch of its bees even if it somehow managed to avoid LA-typical traffic, because it'll have to stop at dozens of lights and slow down for tight turns that are hard to do on a trailer that size.

And that's not even mentioning that the bees aren't covered in a mesh sheet, which as far as I can tell is industry standard, or strapped down in any way to avoid death. Bees are really easy to kill on these trips, and companies are careful as hell while transporting them; there's no way the truck skidding like that (note: the trailer doesn't show it being knocked over, just skidding on the road and hitting the side of another car) would send the beehives all over the road. Dumb. As. Hell.

I do have to give the show some slack here, because as far as I can tell the temperature issues would apply less to africanized honey bees because they can withstand higher temperatures. Don't quote me on that, though, because I couldn't find any information on it because NO ONE TRANSPORTS AFRICANIZED HONEY BEES. They're a public nuisance, aren't cultivated in any large capacity, and discovered wild hives are commonly exterminated. DUMB. AS. HELL.

Past the inaccuracy, though, there's another reason this disaster bothers me, and it's because of optics.

Bees are an endangered species. They're vital to our survival, in fact. So, portraying them as 'killer bees' feels irresponsible. Say it with me:

Bees don't attack unless their hive is threatened.

Before anyone says different about africanized honey bees, they do the same thing. Stinging someone kills a bee; they won't do it just for fun (unlike wasps. I would have endorsed a wasp disaster actually, those guys can go to hell).

Obviously, the bee's hives being squashed across the highway is sure to send them into a frenzy, and it's definitely going to suck for anyone that's currently on that highway, but they're not going to travel around in packs mugging people. That sort of reputation is why people are apathetic towards, or even completely against preserving bee populations. They see bees the same way the media sees sharks; as inherently evil creatures who's only goal is human suffering, rather than living creatures with natural behaviours that are mistaken for antagonistic.

If this was just an episode long, I could definitely cut it some slack. A shorter time means less need to dramatize and mischaracterize bees as inherently predatory for the sake of drama. The way it was done in the renfaire episode a while ago was good; the bees only attacked one person because their queen was stuck in her armour. Normal bee behaviour, that's explained to the viewer and wouldn't lead to fear-mongering since there's a clear, non-antagonistic motive that's scientifically sound.

But, it's not. It's three episodes, and you just can't stretch regular bee behaviour into three episodes. Seriously, the simplest thing they can do is get everyone away from the hive to let the bees calm down, and letting exterminators take care of it. Even if the bees deem their hive destroyed and need to relocate, they generally stay in one place until the scout bees find something suitable to stay in (which can take a bit; and even then , the trailer didn't indicate the nests were crushed or anything, just thrown off the truck.)

My conclusion from all this? The season 8 opener is most likely going to be a contrived, comically unrealistic, damaging depiction of bees meant for drama and shock value, and most of all, I just think it's going to be lame. I'm sorry, you sank a cruise ship last season and the best you could come up with this time was bees? You made complicated and detailed water sets for a gorgeously written split perspective plotline in the season 2 tsunami disaster, and all you could think of was bees?? The volcano in lone star is almost impressively unrealistic, but at least it was more exciting than bees.

Please god let the rest of the season be better than this.

Important end note/disclaimer: the season isn't out yet as I'm writing this, so I literally have no idea how the portrayal is actually going to pan out. Knowing the show, they'll probably address the fact that they're africanized honey bees and not normal bees, which is a good step in the right direction. I personally don't think that's enough, since the optics are pretty fear mongering and especially dangerous with the current climate crisis and state of the bee population in the US, particularly California. If people go out thinking that it's normal for beekeepers to cultivate africanized honey bees, it'll result in a push against conservation efforts, et cetera, you get the gist.

But, I don't know how it's going to pan out. And as someone who genuinely loves this show's writing, I'm just hoping I'm wrong and I'm just taking things worse than they actually are. I know for a fact they can write so much better than this, and have written so much better than this.

The thing I love most about this show has always been how it sets itself apart from other procedurals, like greys anatomy, by creating realistic and complex drama, characters, and keeping most of its situations within the realm of possibility. This season opener feels like the first time they've sacrificed bare minimum realism for drama, and I hope to god that trend doesn't continue.

Uhhhh TLDR: killer bees are an actual type of bee that aren't cultivated, like, ever because they're considered a nuisance to be exterminated in california, and most other states. so, a random truckload of them being out in the middle of LA is wildly unrealistic. On top of that, the hives themselves are missing the usual safety precautions bee transporters have, like mesh nets and any sort of strap to stop the beehives from being flung off the truck. But it doesn't stop there, the portrayal of bees as these killer insects mugging anyone they come across is, you guessed it, also wildly unrealistic and adds to fearmongering around bees, which is not good for our critically declining populations. Their only goal is to defend their hive, and won't stray anywhere near as far as they do in the trailer.

[felassan]

Erika: "Solidarity. We’ll be fulfilling contracts at SDCC but afterwards WE HOLD THE LINE. Labor is entitled to all it creates! ✊🏼🎮" [source] Text in the image reads "What do we do about San Diego Comic-Con? Given the close proximity of the calling of the strike with San Diego Comic-Con ("SDCC"), the strike rules relating to promotion and publicity services do not apply to promotion and publicity services provided at SDCC 2024".

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"The video game companies included in the strike are: Activision Productions Inc., Blindlight LLC, Disney Character Voices Inc., Electronic Arts Productions Inc., Formosa Interactive LLC, Insomniac Games Inc., Llama Productions LLC, Take 2 Productions Inc., VoiceWorks Productions Inc., and WB Games Inc." [source]

SAG AFTRA news update:

"SAG-AFTRA Members Who Work on Video Games Go on Strike July 25th A.I. Protections Remain the Sticking Point SAG-AFTRA National Executive Director & Chief Negotiator Duncan Crabtree-Ireland, acting under the authority delegated by the SAG-AFTRA National Board, and with the unanimous advice and counsel of the Interactive Media Agreement Negotiating Committee, called a strike of the Interactive Media Agreement, effective July 26 at 12:01 a.m. Today’s vote to strike comes after more than a year and a half of negotiations without a deal. The convenience bargaining group with whom SAG-AFTRA is negotiating includes Activision Productions Inc., Blindlight LLC, Disney Character Voices Inc., Electronic Arts Productions Inc., Formosa Interactive LLC, Insomniac Games Inc., Llama Productions LLC, Take 2 Productions Inc., VoiceWorks Productions Inc., and WB Games Inc. Any game looking to employ SAG-AFTRA talent to perform covered work must sign on to the new Tiered-Budget Independent Interactive Media Agreement, the Interim Interactive Media Agreement or the Interim Interactive Localization Agreement. These agreements offer critical A.I. protections for members. Negotiations began in October 2022 and on Sept. 24, 2023, SAG-AFTRA members approved a video game strike authorization with a 98.32% yes vote. Although agreements have been reached on many issues important to SAG-AFTRA members, the employers refuse to plainly affirm, in clear and enforceable language, that they will protect all performers covered by this contract in their A.I. language. “We’re not going to consent to a contract that allows companies to abuse A.I. to the detriment of our members. Enough is enough. When these companies get serious about offering an agreement our members can live — and work — with, we will be here, ready to negotiate,” stated SAG-AFTRA President Fran Drescher.   “The video game industry generates billions of dollars in profit annually. The driving force behind that success is the creative people who design and create those games. That includes the SAG-AFTRA members who bring memorable and beloved game characters to life, and they deserve and demand the same fundamental protections as performers in film, television, streaming, and music: fair compensation and the right of informed consent for the A.I. use of their faces, voices, and bodies. Frankly, it’s stunning that these video game studios haven’t learned anything from the lessons of last year - that our members can and will stand up and demand fair and equitable treatment with respect to A.I., and the public supports us in that,” said Crabtree-Ireland. “Eighteen months of negotiations have shown us that our employers are not interested in fair, reasonable A.I. protections, but rather flagrant exploitation. We refuse this paradigm – we will not leave any of our members behind, nor will we wait for sufficient protection any longer. We look forward to collaborating with teams on our Interim and Independent contracts, which provide A.I. transparency, consent and compensation to all performers, and to continuing to negotiate in good faith with this bargaining group when they are ready to join us in the world we all deserve." said Interactive Media Agreement Negotiating Committee Chair Sarah Elmaleh.  For more information and to search whether a video game is struck, please visit sagaftra.org/videogamestrike."

[source]

[allaccesssd]

Need Airport Transportation in San Diego, CA? Here Are Your Best Options!

Traveling to and from the airport can be a daunting task, especially in a bustling city like San Diego, CA. With its vibrant culture, stunning beaches, and a plethora of attractions, San Diego draws millions of visitors each year. As such, reliable airport transportation services San Diego, CA are crucial for ensuring a smooth travel experience. This article explores the best options available for airport transportation, highlighting their features, benefits, and how they can enhance your journey.

Understanding Airport Transportation Services

Airport transportation services encompass a wide range of options tailored to meet the diverse needs of travelers. From shuttles and taxis to luxury car rentals and private limousines, there is something for everyone. Understanding these options is essential for selecting the right service that aligns with your travel plans and budget.

Shuttle services are often the most economical choice for travelers. These services operate on fixed routes and can accommodate multiple passengers, making them ideal for individuals or families looking to save on costs. On the other hand, taxis provide a more direct and flexible option, allowing travelers to reach their destinations without any stops along the way.

For those seeking a more luxurious experience, private car services and limousines offer unparalleled comfort and style. These services are perfect for special occasions, corporate events, or simply when you want to indulge yourself. With a professional chauffeur at the wheel, passengers can relax and enjoy the ride without the stress of navigating traffic.

The Benefits of Using Airport Transportation Services

Choosing professional airport transportation services comes with a multitude of benefits. One of the primary advantages is convenience. After a long flight, the last thing travelers want to deal with is navigating public transportation or searching for parking. Airport transportation services provide door-to-door service, ensuring a hassle-free experience from the moment you land to when you reach your destination.

Another significant benefit is reliability. Professional drivers understand the importance of timeliness and are well-acquainted with local traffic patterns. This knowledge allows them to plan the best routes, ensuring that clients arrive at the airport or their destination on time. This commitment to punctuality alleviates travel-related stress, allowing passengers to focus on enjoying their trip.

Safety is also a crucial consideration when choosing airport transportation. Reputable services prioritize safety by maintaining their vehicles to high standards and employing trained drivers. This emphasis on safety helps passengers feel secure during their journey, knowing that they are in capable hands.

Factors to Consider When Choosing Airport Transportation

When selecting airport transportation services in San Diego, CA, several factors should be taken into account. First and foremost, it is essential to assess your specific needs. Different transportation options cater to varying group sizes and preferences. For example, solo travelers may prefer a shuttle service, while larger groups may require a van or SUV for added comfort.

Another critical factor is the reputation of the transportation provider. Researching reviews and testimonials can provide valuable insight into the quality of service offered. Companies with a strong track record of reliability and customer satisfaction are more likely to deliver a positive experience.

Pricing transparency is also vital. While it may be tempting to choose the lowest-priced option, it is essential to ensure that the service provides a clear breakdown of costs. Hidden fees can quickly escalate the price, turning what seemed like a budget-friendly option into an unexpected expense. By requesting quotes and comparing services, travelers can make informed decisions that align with their budget.

Exploring Different Transportation Options

Shuttle Services

Shuttle services are a popular choice for budget-conscious travelers. These services typically operate on fixed schedules and routes, picking up passengers from designated locations and dropping them off at the airport. While shuttles may take longer due to multiple stops, they offer an affordable way to travel, especially for those who don’t mind sharing a ride.

Taxi Services

Taxis offer a more direct and flexible option for airport transportation. With the convenience of being hailed or called, taxis can provide immediate service without the need for reservations. This flexibility is ideal for travelers who may have last-minute changes to their plans or those who prefer a more private experience.

Private Car Services

For travelers seeking a touch of luxury, private car services are an excellent option. These services allow passengers to choose from a range of vehicles, including sedans, SUVs, and vans. With a professional chauffeur who is dedicated to ensuring a comfortable ride, private car services provide a stress-free way to get to and from the airport.

Limousine Services

Limousines are synonymous with luxury and elegance. For special occasions or high-profile business trips, hiring a limousine can elevate the travel experience. Limousine services often include a variety of amenities, such as complimentary beverages, spacious seating, and entertainment options, making them perfect for celebrations or corporate events.

Eco-Friendly Transportation Options

As environmental awareness grows, many airport transportation services in San Diego, CA, are incorporating eco-friendly practices into their operations. Options such as hybrid or electric vehicles are becoming more widely available, allowing travelers to reduce their carbon footprint while enjoying the luxury of professional transportation. Choosing eco-friendly options not only benefits the environment but also reflects a traveler's commitment to sustainability.

Conclusion: Elevate Your Travel Experience with All Access Transportation LLC

Navigating the airport transportation landscape in San Diego, CA, is made significantly easier with the availability of reliable airport transportation services in San Diego, CA. From shuttle services to private limousines, there are numerous options to fit every traveler's needs and budget.

For those seeking a top-tier transportation experience, All Access Transportation LLC stands out as a premier choice. With a commitment to excellence, safety, and customer satisfaction, this company provides a range of airport transportation services that cater to various preferences. Whether traveling for business or pleasure, choosing All Access Transportation LLC ensures a seamless, enjoyable, and luxurious journey. Make your next trip to San Diego unforgettable by opting for professional airport transportation services that prioritize your comfort and convenience.

[datascraping001]

Scraping US Doctors & Dentists Database

Scraping US Doctors & Dentists Database

Unlocking Healthcare Marketing Potential with US Doctors & Dentists Database Scraping

In today’s competitive healthcare landscape, having access to accurate and comprehensive databases of healthcare professionals is invaluable. For companies seeking to connect with medical professionals across the US, DataScrapingServices.com provides a solution with its US Doctors & Dentists Database Scraping services. This service is a game-changer for pharmaceutical companies, medical equipment suppliers, marketing agencies, and other healthcare-related businesses looking to reach a highly targeted audience.

Comprehensive Data Extraction: What We Offer

Our US Doctors & Dentists Database Scraping service extracts a wide range of essential details from various online directories and public sources. Key data fields include:

- Doctor's Full Name: Accurate identification of doctors and dentists.

- Specialization: Information on their fields of expertise (e.g., cardiology, orthodontics).

- Clinic or Hospital Affiliation: Details on where these professionals practice.

- Contact Information: Email addresses, phone numbers, and office addresses.

- Professional Ratings and Reviews: Insights into reputation and patient satisfaction.

By accessing a wide range of data points, you can build a detailed database that supports diverse marketing and outreach strategies.

Benefits of Doctor & Dentist Data Scraping

This database scraping service offers numerous advantages to businesses:

- Targeted Marketing: Personalized communication is crucial in the healthcare industry. With detailed contact and specialization information, companies can tailor their marketing campaigns to connect with specific groups of doctors or dentists based on location, specialty, or type of practice.

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[enrightdigital]

The Importance Of Model Management Services Across Industries

In an increasingly competitive landscape, businesses from various sectors—such as construction, manufacturing, medical, and outdoor retail—are realizing the value of model management services. These services extend beyond the fashion industry, offering comprehensive support for both the models themselves and the companies looking to represent them effectively. This article delves into the essential functions of model management service San Diego and their relevance across different industries.

1. Talent Scouting and Recruitment

Model management agencies play a critical role in scouting and recruiting talent. In industries like construction and manufacturing, the right representation can significantly impact marketing efforts.

Key Aspects:

Diverse Talent Pool: Agencies seek to recruit models who not only fit the aesthetic requirements but also align with the brand's values. This is especially important in fields like medical and outdoor retail, where authenticity is crucial.

Portfolio Development: Models are guided to create professional portfolios that highlight their strengths. A well-crafted portfolio is essential for attracting potential clients, much like a well-designed product brochure in manufacturing.

The Role of Talent Scouting in Various Industries

Industry

Construction

Manufacturing

Medical

Outdoor Retail

Focus of Scouting

Diverse appearances for campaigns

Representation of product lines

Trustworthy and relatable faces

Active and adventurous lifestyles

Importance

Enhances project marketing

Builds trust through relatable models

Eases patient apprehension

Aligns with the brand's adventurous image

2. Career Development and Coaching

Model management services provide coaching that is vital for new talent, similar to training programs in other sectors.

Training Elements:

Skill Development: Models receive training in various aspects, such as posing, runway walking, and public speaking. This is akin to skills training in manufacturing, where workers must be proficient in specific techniques.

Personal Branding: Agencies help models build their personal brands. Just as manufacturers focus on branding to create market differentiation, models need to establish a unique identity that resonates with their audience.

Marketing and Promotion

Effective marketing strategies are essential across all industries. Model management service San Diego help models gain visibility, which is paramount for both the models and the brands they represent.

Marketing Strategies:

Social Media Engagement: Just as outdoor retail brands leverage social media to connect with customers, model management agencies utilize these platforms to promote their talent. Models are trained to engage with followers, enhancing their visibility and appeal.

Networking Opportunities: Agencies facilitate connections between models and brands, similar to how construction firms network to secure contracts. This is vital for securing job opportunities and collaborations.

Marketing Tactics in Model Management

Tactic

Social Media Campaigns

Networking Events

Purpose

Increase visibility and engagement

Build industry connections

Application

Showcase models' work and personalities

Facilitate collaborations with brands

Contract Negotiation and Legal Support

The importance of legal support in model management cannot be overstated. Similar to medical companies requiring legal guidance for compliance, model agencies ensure that contracts are beneficial for their talent.

Key Considerations:

Contract Clarity: Agencies review contracts to ensure they are fair and protect models' rights. This parallels the legal support that manufacturing companies receive to navigate complex contracts with suppliers.

Intellectual Property: Models must protect their image and work. Agencies help navigate the intricacies of intellectual property, much like companies ensure their patents and trademarks are safeguarded.

Career Strategy and Long-term Growth

Just as businesses strategize for long-term growth, model management service San Diego focus on developing a career path for models.

Strategic Focus:

Career Path Planning: Agencies guide models in defining their career trajectories. This is similar to how businesses assess market trends to adapt their strategies accordingly.

Financial Management: Some agencies offer financial advice, helping models manage their earnings. This is reminiscent of the financial planning that companies undergo to ensure sustainability.

Model Welfare and Support

Support systems are vital for models, similar to the employee welfare programs many companies implement.

Welfare Initiatives:

Health and Well-being: Agencies prioritize the physical and mental health of their models, much like how medical companies focus on employee well-being.

Conflict Resolution: Model management services by Enright Digita provide mediation in disputes, similar to human resource functions in larger organizations.

Conclusion

Model management service San Diego are integral to the success of models across various industries, including construction, manufacturing, medical, and outdoor retail. By focusing on talent development, marketing, legal support, and career strategy, these services ensure that models not only thrive individually but also contribute positively to the brands they represent. As the modeling industry continues to evolve, the relevance of model management services will only increase, further bridging the gap between talent and opportunity across diverse sectors.

In this interconnected world, understanding the multifaceted role of model management can help businesses leverage talent effectively, ensuring that both models and brands reach their fullest potential

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Science: Did a top NIH official manipulate Alzheimer's and Parkinson’s studies for decades?

In 2016, when the U.S. Congress unleashed a flood of new funding for Alzheimer’s disease research, the National Institute on Aging (NIA) tapped veteran brain researcher Eliezer Masliah as a key leader for the effort. He took the helm at the agency’s Division of Neuroscience, whose budget—$2.6 billion in the last fiscal year—dwarfs the rest of NIA combined.

As a leading federal ambassador to the research community and a chief adviser to NIA Director Richard Hodes, Masliah would gain tremendous influence over the study and treatment of neurological conditions in the United States and beyond. He saw the appointment as his career capstone. Masliah told the online discussion site Alzforum that “the golden era of Alzheimer’s research” was coming and he was eager to help NIA direct its bounty. “I am fully committed to this effort. It is a historical moment.���

Masliah appeared an ideal selection. The physician and neuropathologist conducted research at the University of California San Diego (UCSD) for decades, and his drive, curiosity, and productivity propelled him into the top ranks of scholars on Alzheimer’s and Parkinson’s disease. His roughly 800 research papers, many on how those conditions damage synapses, the junctions between neurons, have made him one of the most cited scientists in his field. His work on topics including alpha-synuclein—a protein linked to both diseases—continues to influence basic and clinical science.

But over the past 2 years questions have arisen about some of Masliah’s research. A Science investigation has now found that scores of his lab studies at UCSD and NIA are riddled with apparently falsified Western blots—images used to show the presence of proteins—and micrographs of brain tissue. Numerous images seem to have been inappropriately reused within and across papers, sometimes published years apart in different journals, describing divergent experimental conditions.

After Science brought initial concerns about Masliah’s work to their attention, a neuroscientist and forensic analysts specializing in scientific work who had previously worked with Science produced a 300-page dossier revealing a steady stream of suspect images between 1997 and 2023 in 132 of his published research papers. (Science did not pay them for their work.) “In our opinion, this pattern of anomalous data raises a credible concern for research misconduct and calls into question a remarkably large body of scientific work,” they concluded.

Neither Masliah nor the various drug companies, universities, or federal ­agencies that were provided the dossier have so far rejected or challenged any of its examples of possible misconduct despite being given the material more than 2 weeks ago. And today, the National Institutes of Health (NIH) released a statement saying that following an investigation, it had “made findings of research misconduct” against Masliah for “falsification and/or fabrication involving re-use and relabel of figure panels” in two publications. According to the statement, Masliah no longer serves as NIA’s neuroscience division director, but NIH declined to further clarify his employment status.

Masliah and Hodes, via a spokesperson, declined to reply to detailed questions, provide an interview, or comment on the dossier. NIH Director Monica Bertagnolli also declined to comment. And Masliah did not reply to Science’s requests for raw images and other data related to the examples in suspect papers, or to a new request for comment on the NIH misconduct finding.

The dossier challenges far more studies than the two cited in NIH’s statement, including many that underpin the development and testing of experimental drugs (see sidebar). Masliah’s work, for example, helped win a nod from the U.S. Food and Drug Administration (FDA) for clinical trials of an antibody called prasinezumab for Parkinson’s. Made by Prothena—a company backed by big money—the drug is intended to attack alpha-synuclein, whose build up in the brain has been linked to the condition’s debilitating physical and cognitive symptoms.

But in a trial of 316 Parkinson’s patients, reported in 2022 in The New England Journal of Medicine, prasinezumab showed no benefit compared with a placebo. And volunteers given infusions of the antibody suffered from far more side effects such as nausea and headaches than those in a placebo group who received sham infusions. Prothena is now collaborating in another trial of the drug candidate involving 586 Parkinson’s patients.

The creators of the dossier, who were unaware of NIH’s probe when they spoke with Science, emphasize that they are not themselves accusing Masliah or his colleagues of fraud or misconduct. They note that some of the identified image problems might have been simple errors, and that when images are prepared for publication, some can acquire innocent visual artifacts that resemble improper changes. Distinguishing the two sometimes requires comparison to raw, high-resolution images and other data, which the dossier’s authors did not have. But they say their findings merit formal investigations.

The enormity of apparent problems described in the Masliah dossier stunned 11 neuroscientists who agreed to review it for Science. “Breathtaking,” says neuroscientist Christian Haass of the Ludwig Maximilian University of Munich. “People will, of course, be shocked, as I was. … I was falling from a chair, basically.”

He and the other researchers didn’t personally verify every example of possible misconduct, but they agreed that most of the suspect work cannot reasonably be explained as careless errors or publishing anomalies. “I’m floored,” says Samuel Gandy, a prominent neurologist at the Mount Sinai Alzheimer’s Disease Research Center who was visibly shaken during a video interview. “Hundreds of images. There had to have been ongoing manipulation for years.”

Gandy was disturbed, for example, that Masliah and colleagues seem to have used the same image of a mitochondrion, a cellular energy-producing structure, in two articles on different topics published 2 years apart in different journals. “The bus driver could see that they are identical,” Gandy says.

MASLIAH IS THE SOLE common author on every paper in the dossier, usually taking the first or last position in multiauthor articles. Those positions imply he did the majority of the publication’s work or bears primary responsibility for it, although the others contributed.

Several of the neuroscientists who reviewed the dossier say it seems implausible that Masliah was duped by a colleague. “Given the extended time frame and huge number of differing collaborators and co-authors on these papers, [possible misconduct] by a rogue postdoc or a collaborating scientist doesn’t apply here,” says Tim Greenamyre, director of the University of Pittsburgh Institute for Neurodegenerative Diseases. “I have a hard time believing that he didn’t know, whether he changed the images himself or somebody else did so on his behalf.”

I’m floored ... Hundreds of images. There had to have been ongoing manipulation for years.

Samuel Gandy

Mount Sinai Alzheimer’s Disease Research Center

At a minimum, according to neuroscientists who spoke with Science, the large volume of doubtful images erodes trust in Masliah’s overall body of work. All 11 who reviewed the dossier agree that all his problem papers should be investigated by NIH, scholarly journals, funders, and UCSD. The university declined to comment, and NIH did not say whether it planned or was conducting a broad misconduct investigation into his research. Masliah this week, days after NIH said it concluded its probe, still appeared with Hodes, the NIA director, to give introductory remarks at the start of a national Alzheimer’s summit on the NIH campus.

As a division director, Masliah would hold sway over NIA’s neuroscience funding, according to Alan Leshner, who previously led two other NIH institutes and headed AAAS (publisher of Science) until 2015. In most cases, he says, institutes select grants based on scores awarded by peer-review “study sections.” But institute and division directors can fund preferred projects, such as studies of amyloid, the brain protein linked to Alzheimer’s disease, over better scoring competitors.

“There’s no question that in most cases, a division director … is viewed as someone who has the judgment to set priorities,” Leshner says. They can also alter the direction of a field. If a division director shows interest in a particular aspect of neuro-science related to aging, he adds, “you get [many] proposals in the next round in that area.”

There’s no evidence that Masliah has been a poor steward of NIA’s neuroscience budget or directed it down blind alleys underpinned by suspect data, but NIH’s statement today still leaves many crucial questions unaddressed.

“The volume of papers and resources involved are enormous—as is Dr. Masliah’s leadership and influence on the field, including drug development pipelines,” says Vanderbilt University neuroscientist Matthew Schrag, one of those who helped assemble the dossier. “That makes it a very influential example of possible misconduct.”

MASLIAH, 65, TRAINED in medicine and neuropathology at the National Autonomous University of Mexico (UNAM), earning his medical degree in 1982 and completing a residency in pathology in 1986. He married a U.S. resident who also studied medicine at UNAM. They relocated to San Diego after Masliah’s training.

Soon after, he landed a plum research fellowship in the lab of Robert Terry, a titan in neuropathology and Alzheimer’s research who reportedly received NIH’s first grant for the neurodegenerative condition in the 1960s. “I was incredibly lucky to meet Dr. Bob Terry,” he told a UCSD interviewer in 2016. In a 1990 photo of Terry’s lab staff, a dark-bearded, youthful Masliah stands proudly, arms folded and wearing his trademark large glasses, beside his famous mentor, who died in 2017. Terry and Masliah pioneered the use of an optical imaging method known as confocal microscopy to create high-resolution 3D images of brain cells.

Masliah went on the lead UCSD’s Experimental Neuropathology Laboratory, where he contributed to early work on alpha-synuclein and novel antibody and vaccine approaches to attack Alzheimer’s and ­Parkinson’s—some of which led to experimental drugs such as prasinezumab that have reached human trials. For Parkinson’s, he also explored antidepressants, and anti-inflammatory drugs or compounds. And for Alzheimer’s, he looked into compounds to decrease the production of amyloid, which builds up in the brain and forms deposits known as plaques outside neurons.

Neurologist Douglas Galasko, who formerly directed the UCSD Alzheimer’s Disease Research Center, where Masliah worked, praises his scholarship and character, calling him “highly collegial and very hardworking.” Galasko co-authored five papers in the dossier, making modest contributions unrelated to apparently doctored images. (He opted not to view the document.)

Galasko says he never heard concerns or doubts about Masliah, whom he describes as “very serious, yet warm and thoughtful, and engaging to have a conversation with.” Those qualities earned him long-term loyalty from investigators working in his lab, Galasko adds. “He’s a very effective spokesperson, organizer, and synthesizer of ideas.” Colleagues at UCSD, he notes, felt enormous pride when Masliah took the helm at NIA’s neuroscience division.

Major impact

Eliezer Masliah’s research on Parkinson’s and Alzheimer’s diseases has enjoyed global influence. His output, as well as the number of citations to his papers, place him among the world’s top 10 scientists in certain subfields (highlighted in red).

“NIA sets the agenda worldwide for age-related diseases,” says Scott Ayton, who directs a neuroscience center at the Florey research institute in Australia, echoing peers in the U.S. and Europe. He was among those who reviewed the dossier and considered the concerns highly credible.

University of Texas at San Antonio neuroscientist George Perry, chief editor of the Journal of Alzheimer’s Disease, describes Masliah’s research as influential and well-regarded, as do other experts in neurodegenerative diseases. In key topics related to Alzheimer’s and Parkinson’s, Masliah frequently ranks in the global top 10 researchers—and often first—by number of papers and citations to them, according to an analysis of data from Dimensions Analytics, a scholarly research data bank from the U.K. company Digital Science (see chart, above). For example, Masliah placed first for papers that use the terms “synuclein” and “synapse.”

His most influential work includes fundamental studies of synaptic damage in mice genetically engineered to mimic various neurodegenerative conditions. “People are very dependent on all of these descriptions,” says Perry, who also reviewed the dossier on Masliah’s research for Science. Many are among the 132 questioned papers, which have racked up more than 18,000 citations, often by leading scholars. “Now I think that work was probably fabricated, in part,” Perry adds, calling the influence of the questioned papers “very problematic.”

BEGINNING IN 2023, forensic image sleuths began to flag a few papers in which Masliah played a central role, posting to PubPeer, an online forum where research publications are discussed and allegations of misconduct often raised. In a few cases, Masliah or a co-author replied or made corrections. Soon after, Science spotted the posts, and because of Masliah’s position and standing decided to take a deeper look.

Schrag, Columbia University neurobiologist Mu Yang, and independent forensic image analyst Kevin Patrick agreed to examine a wider swath of Masliah’s output. (Patrick, a nonscientist who uses the moniker “Cheshire” on social media, had pseudonymously submitted several PubPeer posts on Masliah papers.) In 2023, after a similar request from Science, the same group had assessed work by University of Southern California (USC) Alzheimer’s and stroke expert Berislav Zlokovic. Their dossier of possible misconduct and a subsequent Science report prompted university and NIH investigations, which are apparently ongoing, and led NIH to pause a late-stage clinical trial of a stroke drug based in part on apparently manipulated studies.

For the new dossier, Schrag provided examples, technical context, and expertise on how the findings might affect the promise of prasinezumab and other drugs. Yang took the lead role in identifying and examining questionable images. She used Image- twin, a software program, to assist her own personal scrutiny. (The software, for example, initially spotted the reused mitochondrion image.) Schrag and Yang worked independently of their employers.

Microbiologist and research integrity expert Elisabeth Bik, who also worked on the Zlokovic dossier, contributed other Masliah examples and reviewed and concurred with almost all of the findings. All of the dossier authors worked as volunteers, poring over papers and images in their spare time. The group says it will post many of the examples from the Masliah dossier on PubPeer for others to review; Schrag provided the dossier to NIH, as did Science in the course of producing this story. (NIH’s statement says it had initiated its own investigation much earlier, in May 2023, after receiving allegations from the HHS Office of Research Integrity [ORI].)

In Yang’s analysis of multiple Masliah-authored papers, duplicated sections in some Western blots that had been “seamlessly blended” quickly floated into view, she says. “It tells me someone put a lot of thought and effort into the image … and usually indicates something is very wrong.”

Yang began to see patterns in the apparent image doctoring, which also included images that had been duplicated or seemingly altered by “cloning” portions of them. “I started feeling like a curator or art historian—when you look at a piece of art without the label, you know the artist by the style. Like a painting from Picasso’s blue period,” she adds, “it’s a signature style that I saw in many, many papers—the way they lay out the figures, even the color contrast.”

After finding hundreds of questionable images, the group had more than enough strong signs of misconduct and stopped looking, Yang says. But she suspects similar problems would emerge from a close examination of the hundreds of other Masliah papers.

Making a drug look better?

National Institute on Aging neuroscience chief Eliezer Masliah was senior author of a 2015 study of the Alzheimer’s disease treatment Cerebrolysin in BMC Neuroscience. Brain-tissue images from normal mice and mice engineered to overexpress a mutant form of the tau protein might have been doctored to suggest the drug reduces damage from the tau.

Overlapping copies

In the paper, normal (non-tg) mice show no tau damage. The mutant mice (3RTau) show tau damage unless treated with Cerebrolysin. But a merged image of the younger, normal mouse and the older, treated mutant appear unnaturally similar. Yellow sections are identical.

A series of clones

Dissimilar (red or green) areas within the merged image seem to be caused by efforts to obscure the duplication. Small “cloned” areas within each image are indicated by same-color boxes. The journal’s publisher said it would review the concerns.

YANG AND THE OTHER authors say the ongoing human trials of prasinezumab add to the urgency of their findings. According to Prothena, the drug blocks the spread of toxic alpha-synuclein and might slow the progression of Parkinson’s movement disorders and dementia. Prasinezumab’s documented side effects have not been dangerous. But if it is based on suspect scientific foundations and, as the first clinical results suggest, ineffective, further clinical testing could raise false hopes and divert patients from trials of other experimental drugs.

The concept for prasinezumab emerged from Masliah’s ties to the late Dale Schenk, a UCSD-trained neuroscientist whose research helped pioneer the idea of treating Alzheimer’s and Parkinson’s with vaccines designed to block the buildup of harmful amyloid and synuclein. Masliah, Schenk, and others proposed that immunizing people with benign parts of each protein could spur the immune system to produce antibodies that might block the full, toxic form. Infusing labmade antibodies might have the same effect. Either approach, they hypothesized, could offer a “disease modifying” attack on a condition’s root cause, rather than merely alleviating symptoms.

In a 2016 post on Alzforum, Masliah recalled an early discussion with Schenk on the idea. “Dale and I sat at a coffee shop (his favorite place) next to the Pacific Ocean and drew, on a napkin, the concept of how a potential synuclein vaccine might work,” he said. “People strongly doubted the potential use of a vaccine approach in Alzheimer’s and even more so in Parkinson’s. Dale was one of the few who listened and believed in the idea.”

To pursue that vision Schenk co-founded and served as chief executive of Prothena, spun off in 2012 from the former biopharma company Elan. Masliah worked extensively with Schenk until his death from pancreatic cancer at age 59 in 2016. Four of their joint studies, published between 2005 and 2017, proved foundational for prasinezumab, according to Prothena’s promotional material. Schenk was senior author on two of the papers, Masliah on two. All four used apparently doctored images, according to the dossier, as did other Masliah papers cited in clinical trial reports as important to prasinezumab’s development. Some of the papers suggested Parkinson’s symptoms could be generated in mice engineered to produce alpha-synuclein, and that those symptoms could be reduced by injecting antibodies akin to prasinezumab into the animals.

Greenamyre, a Parkinson’s specialist, says the papers showed an “astonishing level” of apparent image manipulation. But he notes that the image anomalies and the drug’s lack of success so far don’t necessarily mean “that synuclein is a bad target or that targeting it with antibodies is never going to work.” The clinical trial team testing the antibody reported earlier this year in Nature Medicine that a small subgroup of its patients showed hints that prasinezumab slows the worsening of movement symptoms—although the group acknowledged that the finding emerged in a “posthoc analysis,” a secondary review unrelated to the trial’s hypothesis.

Manipulations in key experiment?

Five images in a 2005 paper in Neuron from Masliah and Prothena founder Dale Schenk appear to have been doctored in ways that could influence paper's findings. It is among several papers cited as key to the experimental drug prasinezumab that show apparent falsifications.

Still, “The discovery that key papers supporting this approach contained manipulated figures certainly muddies the waters,” Greenamyre says. He’s now hoping independent studies will determine whether “the rationale for clinical development remains on firm ground—or if it is now a little shaky.”

“We do not interpret these claims as specifically relevant to the current prasinezumab clinical program,” Prothena told Science in a brief statement responding to questions about the image anomalies related to the drug.

Swiss pharma giant Hoffmann-La Roche, which partnered with Prothena to develop prasinezumab in 2013, also supplied a statement in response to Science’s questions, saying it would continue clinical development of the drug. “The evidence supporting targeting alpha-synuclein aggregates as a mechanism of action in [Parkinson’s] is based on a wide range of sources,” it stated. In the interest of scientific integrity, Roche added, “We are working to further understand the details of this matter.”

Roche has agreed to pay Prothena up to $620 million if its drug candidate passes a series of performance goals. So far, Roche has paid $135 million.

Schenk and Masliah shared inventor credit in patents in the U.S. and Europe related to synuclein, amyloids, and related science, and they and their co-inventors assigned the rights to Prothena, UCSD, or both. Numerous other Prothena patents refer to suspect work cited in the dossier. Prothena and NIH did not respond to questions about whether Masliah has received or was promised royalties.

The dossier also questions some of Masliah’s earliest work on alpha-synuclein, raising further doubts about the foundations of Prothena’s drug. A seminal 2000 Masliah article in Science, for example, suggested alpha-synuclein might kill certain brain cells and speed the development of brain deposits called Lewy bodies that are hallmarks of Parkinson’s and are often seen in Alzheimer’s patients. But the paper contains an apparently doctored image and another image the dossier authors deemed questionable.

Other researchers have yet to validate aspects of that study, according to Ayton and neurologist Michael Okun of the University of Florida.

“A single nonreplicable finding is in itself not worrisome,” Okun says. But it raises greater concern in light of “convincing evidence of spliced and cloned images which appeared frequently in the decades following.” He calls it “deeply troubling” that FDA greenlighted human trials of prasinezumab based largely on suspect papers from Masliah’s lab.

People will, of course, be shocked, as I was. ... I was falling from a chair, basically.

Christian Haass

Ludwig Maximilians University Munich

FDA declined to comment on the prasinezumab findings challenged within the dossier. Holden Thorp, editor-in-chief of the Science family of journals, says the journal will “contact the authors [of the 2000 paper] to hear their response to these concerns. If any adjustments are required, we will certainly make them.” (Science’s News department is editorially independent of the journal.)

The new phase 2 trial of prasinezumab is examining whether it might slow the progression of certain movement difficulties caused by Parkinson’s, as the posthoc analysis suggested it might. Roche and Prothena expect to announce preliminary results later this year. The companies would likely decide in 2025 or 2026 on whether to move on to phase 3 trials—larger efficacy experiments needed for possible FDA approval.

The findings in the dossier cast a shadow on the other drug development efforts that rely on Masiah’s challenged work. And they raise questions about the roles and responsibilities of the many prominent scientists as well as more junior researchers who collaborated on some of his suspect experiments.

UCSD neuroscientist Edward Rockenstein, who worked under Masliah for years, co-authored 91 papers that contain questioned images, including 11 as first author. He died in 2022 at age 57. And neuroscientist Robert Rissman worked on 16 of the papers highlighted in the dossier, seven as senior author. He managed biomarkers and brain tissue samples for UCSD’s Alzheimer’s Disease Research Center prior to moving recently to USC, where he occupies a similar role and manages programs that try to move basic research into treatments for patients. Rissman did not reply to requests for comment. USC says it will conduct a confidential review of Rissman’s involvement with Masliah’s work.  

Haass questions whether Masliah’s closest collaborators could have remained unaware of the steady stream of apparent image manipulation, even if they were not personally culpable. “I mean, come on,” he says. “They must know.”

Other neuroscientists who spoke to Science urged caution in placing blame. “We should be careful … not to rush to judgment on the generation of researchers who may have been innocent members of this laboratory over the span of 20-plus years,” Okun says. “It is entirely possible that many were unaware of improprieties.”

In its statement today, NIH provided few details about the agency’s own investigation into Masliah’s work, including whether it had examined more than two of his publications. The agency says it has notified ORI of its findings and that the NIA deputy director, Amy Kelley, is also now acting head of the neuroscience division.

Given the NIH misconduct determination and the questions raised by the dossier about more than 100 other papers, many scientists—and perhaps congressional appropriators and the public—might question NIH’s vetting process for key roles and how Masliah retained stewardship of NIA’s billions of neuroscience dollars for so long. “For so important a job, you want somebody who is beyond reproach. You want somebody to be an exemplar of what you aspire to be,” Greenamyre says.

By the time NIA hired Masliah in 2016, image manipulation in scientific papers had already become a general concern. Prominent researchers increasingly faced accusations of image manipulation, plagiarism, or other misconduct—which often proved credible. But a former NIA official who would only speak if granted anonymity says he assumes the agency did not assess Masliah’s work for possible misconduct or data doctoring before he was hired.

Indeed, NIH told Science it does not routinely conduct such reviews, because of the difficulty of the process. “There is no evidence that such proactive screening would improve, or is necessary to improve, the research integrity environment at NIH,” the agency added.

Gandy disagrees. “It has to be part of the process now,” he says.

Greenamyre notes a concern about the episode also voiced by Haass and others who viewed the dossier: “I worry about it giving science a further black eye, just as the public’s confidence in science and scientists is sinking to new depths.” But, Greenamyre says, “In the interest of transparency and scientific integrity, this sad story has to come out.”

Questionable papers underpin other drugs

By Charles Piller

The possibility that neuroscientist Eliezer Masliah doctored images in scientific writings for decades is likely to provoke anxiety among multiple drug companies. The concerns documented by whistleblowers most directly challenge an experimental Parkinson’s therapy developed by Prothena (see main story). But 238 active patents concerning neurological conditions also cite suspect work noted in the dossier, according to data from Dimensions Analytics. And the corporate holders of those patents include dozens of firms at work on treatments.

The Austria-based biopharma company Ever Pharma relied heavily on Masliah’s questioned work in developing Cerebrolysin, a mixture of peptides—short chains of amino acids—derived from pig brains. Eight studies conducted at Masliah’s former lab at the University of California San Diego, funded in part by Ever Pharma, indicated the mixture suppresses brain inflammation, promotes growth of new brain cells, and has other benefits that could help dementia patients.

Small clinical trials of Cerebrolysin have suggested modest cognitive benefits in Alzheimer’s disease and vascular dementia, and Ever Pharma now distributes the drug in dozens of nations to treat dementia and stroke. But no large trials have demonstrated it helps dementia patients, and the Food and Drug Administration has not approved Cerebrolysin for use in the United States. And the eight lab studies used suspect images, according to the dossier.

For example, an article by Masliah and colleagues, in BMC Neuroscience in 2014, described the purported benefits of Cerebrolysin for symptoms of neurodegeneration in mice, including reducing mitochondrial damage. Another, published in Neurotoxicity Research in 2016, concerned mice infected with HIV. It republished what appears to be the same image of a mitochondrion.

A spokesperson for Springer Nature, publisher of Neurotoxicity Research, says the concerns will be examined, and responded to if warranted. Stefan Winter, who heads R&D for Ever Pharma’s neurological division, said in a written statement to Science that none of the challenged work in the dossier “played a crucial role in the clinical development of Cerebrolysin.” But, he added, “We take [the allegations] seriously. We will therefore review Prof. Masliah’s work based on the information you provided and refrain from using data from the mentioned publications until this matter is clarified.”

Another company, Neuropore Therapies, cites seven other papers in the Masliah dossier—all with apparently doctored images—as important to the company’s potential drugs for Parkinson’s. Masliah co-founded Neuropore in 2008 but no longer has any apparent affiliation. The most prominent drug candidate his work helped develop, minzasolmin, is in early clinical trials and targets the protein alpha-synuclein for Parkinson’s.

Masliah also provided imaging services for a 2023 paper in NPJ Parkinson’s Disease. The images, which purportedly show enhanced benefits in mice from minzasolmin, appear to be altered, according to the dossier. The concerns will be examined and responded to if warranted, says the journal’s publisher, Springer Nature. “We stand by our data related to clinical development programs,” said Mark Yung, executive chairman of Neuropore, in a brief written reply to detailed questions.

Minzasolmin has Big Pharma backing. In 2015, Neuropore licensed rights to develop and commercialize it and other molecules to the Brussels-based pharma company UCB for $63 million, plus possible future payments. In turn, the Swiss pharma titan Novartis paid UCB $150 million of a possible $1.5 billion for codevelopment rights for minzasolmin and another experimental drug.

“UCB will investigate the preclinical publication on minzasolmin” described in the Masliah dossier and will respond should “evidence of impropriety emerge,” said company spokesperson Laurent Schots in a written statement. But UCB knows of no “facts or circumstances that raise concerns on the quality, validity, and safety of the ongoing clinical development program for minzasolmin,” which is supported by evidence beyond the suspect Masliah work, Schots added.

Preliminary results for the drug’s efficacy from a clinical trial of 496 people in the U.S., Canada, and Europe could be announced later this year.

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Politics 

Supervisors Deadlock on Proposal to Take Aim at Social Media Platforms

The San Diego County Board of Supervisors Tuesday deadlocked on advancing a proposal aimed at protecting young people from being victims of the “addictive algorithms” of social media, with the board voting 2-2.

On July 8, Vice Chair Terra Lawson-Remer announced the proposal, directing the county’s legal team to explore filing and/or joining litigation against social media platforms for “their failure to protect youth mental health,” Lawson-Remer said in a statement at the time.

In addition, the proposal called for a resolution to support the U.S. surgeon general’s effort to put warning labels on social media platforms.

On Tuesday, Lawson-Remer and colleague Monica Montgomery Steppe voted in favor, while their colleagues Joel Anderson and Jim Desmond were opposed.

Chairwoman Nora Vargas was absent from the meeting due to personal reasons, according to her office.

Last week, Lawson-Remer said children “are being harmed by social media. It is affecting their mental and emotional well-being.”

“These platforms have knowingly developed addictive algorithms akin to the opioids manufactured by pharmaceutical companies. I want our county to legally intervene and throw our support behind the U.S. surgeon general’s recommendations,” she added.

Last year, Surgeon General Vivek H. Murthy warned that social media are “contributing to our nation’s youth mental health crisis.”

The American Psychological Association followed suit, linking social media use to reduced well-being and mood disorders — chiefly depression and anxiety — among people between the ages of 10 and 25.

The APA reported that U.S. teens spend an average of five hours every day using the seven most popular social media apps, with Instagram, TikTok and YouTube accounting for 87% of their social media time.

According to Lawson-Remer’s office, “Youth are now exposed daily to strategically designed social media algorithms and features that capitalize on their vulnerabilities to drive engagement.”

In a statement after the Tuesday vote, Lawson-Remer said she would bring back the proposal for a board vote in August.

She added that seeking out legal options would allow the county “to hold opportunistic social media companies accountable and push them to change the way they do business.”

During the Tuesday meeting, Lawson-Remer said social media is a tool for sharing information and entertainment, but can be harmful without guardrails.

Citing different studies, Anderson wanted Lawson-Remer’s proposal to include a report on how marijuana use affects young people’s mental health.

Anderson said that, in his district, more young people are impacted by marijuana use than by social media.

He added that, according to the state Department of Health, there were almost 65,000 cannabis-related emergency visits from those aged 15 to 30 in 2022.

Lawson-Remer said that while she appreciated the spirit of Anderson’s request, the core of her proposal involved possible legal options against social media companies. She also told Anderson that his proposal could be discussed at a future meeting.

Desmond said while he understood why Lawson-Remer introduced the proposal, he wasn’t sure a lawsuit was the best way to deal with how social media affects young people.

Instead of more regulation, Desmond proposed an educational program for children and their parents.

“Where does government end and parenting start?” Desmond asked, suggesting that parents can be given tools, such as blocking certain sites on phones or being alerted to a child’s use.

During a public comment period, supervisors heard from two young people and an LGBTQ activist in support of Lawson-Remer’s proposal.

A high school student said that, at first, social media allowed him to stay in touch with his family, but it kept him “disconnected as ever” and capitalized on vulnerabilities.

A woman calling herself “Oliver Twist” said she opposed any social media policy, as government should be limited.

While social media are a problem, she noted that a Metropolitan Transit System poster encouraged youth ridership by asking young people to post pictures on social media platforms such as Instagram and TikTok. *Reposte3d article from The Times of SD by Elizabeth Ireland on July 16, 2024

[300apftsoldier]

“TRUST” You want someone you can trust above all else.

Loyalty

Duty

Respect

Selfless Service

Honor

Integrity

Personal Courage

I’m a professional driver that provides personal security. I’m looking for an individual or family work for, long term.

Michael E Spangler

Army National Guard Soldier

2010 to present

El Cajon, CA 92021

56M: PMOS: Religious Affairs NCO, PSD: Personal Safety Detail

and driver for our company Chaplain.

91B: SMOS: Light Wheeled Vehicle Mechanic, Combat Lifesaver,

Combatives training, Proficient with a sidearm and rifle.

WORK EXPERIENCE

United States Army National Guard

01/11/2022 to 02/19/2022

I was the NCOIC:

Non Commissioned Officer in charge. I was deployed to a COVID testing site.

I was placed in charge of, and provided safety for, three enlisted Soldier’s and 7 civilian workers.

Not to mention the countless civilian’s that came through to be tested daily.

United States Army National Guard

02/19/2022 to 06/30/2022

I became a Wild Land Firefighter for Cal Fire. I deployed, engaged, and controlled wild land fires with my team.

United States Army National Guard

08/30/2021 to 09/12/2021

I was the Squadron Commanders P.S.D: Personal Security Detail and driver during the Caldor, Dixie fires and in the vicinity of Lake Tahoe and Greenville. I was also the companies Sergeant at Arm’s as well.

I worked for a family as their personal security and driver.

12/2020 to 07/2021

United States Army National Guard (L.A. Protests 2020)

My mission consisted of protecting and serving my fellow brothers and sisters at arms plus, supporting the L.A.P.D. with their mission, not to mention the civilians/citizens of Inglewood California. My Soldier and I had to drive into Inglewood daily, to make our presence known and keep up public relations. 05/30/2020 to 06/09/2020

Allied Universal Security

Security Professional

I personally checked and verified all personnel, visitors, employees, staff, and company identification and equipment before entering the Entrance Control Points. I conducted employee/visitor baggage inspections. Which includes vehicle inspections as well. I interacted with foreign nationals and government/military/DOD employees on a daily basis. My duties placed me at different ECP’S throughout the week. I carried a sidearm.

09/2019 to 02/01/2020

JRC Consulting

Supervisor//Security Officer

I provide security for JRC'S clients, their property, their assets, and also sensitive material. Discretion and peace of mind are some of their highest priorities.

07/12/2019 to Present

Operation Enduring Freedom (Spartan Shield)

Sentry/Escort, checking/verifying identification, looking for contraband, and I.E.D.’S.

I personally searched/inspected over 3,000 military and civilian vehicles, plus personnel as well. We looking for, weapons, ammo, explosives, contraband, classified material, and I.E.D'S.

My role overseas was all sentry work, combined with escorting foreign nationals in and off the base. I was stationed in the watchtowers as well. We conducted surveillance/overwatch for all vehicles entering and exiting the base. I performed identification checks at every E.C.P. point I was assigned to. We carried sidearms and M-4's.

10/2017 – 09/2018

The Bodyguard Group of Beverly Hills

10/2016 – Present

Close Range International Inc.

07/2016 – Present

Presidential Limousine

Chauffeur and Safety

01/2013 – 01/2014

Private Security

Night Clubs and Bars - Pacific Beach, CA - 1993 to 1996

Canes/Hurricanes Nightclub, Tremors nightclub, Plum Crazy, Stingers,

PB Bar and Grill, U31, patron assistance/identification verification.

Private Security

Dignitary Protection International Agency - San Diego, CA - January 1997 to October 1999 Security/Surveillance, client, and civilian interaction.

Loomis Armored

Driver/Guard

1996 – 1997

Education

United States Army National Guard

08/19/2022 to 10/07/2022

I attended and graduated from:

The Institute for Religious Leadership.

United States Army National Guard

WLC: Warrior Leadership Course

(Sergeants School)

Rank: Sergeant

2018 to Present

A.S.C. Advanced Security Concepts

Comprehensive Security Training: BSIS

Baton, Conflict Resolution, Taser Training, Executive Protection Fundamentals, Sexual Harassment, BSIS Exposed Firearms Training, Handgun Shooting Tactics, Arrest and Control, Chemical Agents Training and CPR/AED certified.

United States Army

Structured Self Development

40 hour course

Rock Church

Community Chaplain

Class

California Career School 1100

Technology Circle Anaheim CA

92805 United States Other

Commercial Truck/Bus Driver

Santiago Canyon College

8045 E Chapman Ave Orange, 92869

School/Local 12/Union

Apprenticeship Program

Heavy Equipment Operator

Grossmont Community College

8800 Grossmont College Dr.

El Cajon CA 92020-1765 US

San Diego CCD - Miramar

College 3375 Camino Del Rio S

San Diego CA 92108-3807 US

Azusa Pacific University

San Diego Campus

Masters of Divinity Program

Groups and Affiliate’s

Aloha Church: 2019 to Present

Calvary Chapel (Football)

Competitive Flag Football. If you’re not bleeding or broken, you’re not winning.

2000 to Present

Commendations/Awards

Army Achievement Medal (2nd Award) // National Defense Medal (2nd Award)

Global War on Terrorism // Global War on Terrorism Service Medal //

Expeditionary Medal // Overseas Service Ribbon // Armed Forces Reserve Medal //

Army Service Ribbon // State Army Service Ribbon //

Army Physical Fitness Badge (10th Award)

[greython9j]

Hotel renovations near me

Like the rest of California, San Diego's hotel industry has been flourishing lately. In California, the number of mid-range and luxury hotels has skyrocketed, and San Diego is no different. This general contractor, who primarily serves the hospitality and tourism sectors, is based in the San Diego area. The San Diego branch's financial performance is greatly impacted by the hotel industry. We focus a lot of our attention on the San Diego region. We cover all of San Diego's neighborhoods and downtown areas.

A thorough understanding of both the owner's requirements and the hospitality industry is necessary for a high-quality repair. Things may not work out if the company you select lacks the necessary expertise. If you can remain hidden, your chances of surviving will be significantly increased. They may not be able to offer suggestions for good local hotels, so you might want to look elsewhere. Not many applicants have emphasized how important the business culture is. Only the most worthy people receive invitations to join exclusive international organizations. We expect a lot of exciting things to happen.

We can work with any international hotel chain since we are flexible. Hotel renovations near me If everything goes as planned, we'll be more equipped to take advantage of opportunities when they present themselves. Like us, there are a plethora of different service suppliers in the market. We handle construction, maintenance, and insurance claims. They have proven helpful several times. We won't squander time trying to provide a comprehensive list of our achievements. One of the main reasons Greython Construction has such a great reputation is because of the commitment and knowledge of its employees. The outcomes of these efforts are very favorable when all variables are taken into account. You can be certain that every guest will receive the best care possible because our highly skilled personnel has a wealth of experience in the hospitality industry. Our crew is capable of handling any problem that may come up while a hotel is being built or renovated. The need for hotel services is rising as an increasing number of businesses, both big and small, are making upgrades. Their fresh insights may prove advantageous for hotel maintenance techniques both traditional and nontraditional. They have no trouble switching between the two settings. As the need for lodging rises, an increasing number of hotels are being planned and constructed. This is largely because the public and private sectors are in great demand for their services. There are numerous establishments with five stars. We would love to have someone on our team with hotel construction or renovation experience. Those who possess wisdom and experience have lived longer and are more resilient in the face of difficulty. What makes them unique is their amazing ability to adjust to different environments. It is undoubtedly possible to apply what one has learned in one situation to another.

The doctor has prescribed a tranquil stay at the Greython Hotel. You never know who you might run into here that can give you a hand if you ever find yourself in a tight spot. You couldn't be in a better place at this time, in my opinion. The dining halls of Greython are perfect for a gathering like this.

The construction management of the hotel is working very hard to have everything finished before the busy season starts. Please don't hesitate to get in touch with us at any time to discuss developing hotels and related businesses. Long-term business success will depend on this. Any reputable construction company knows the value of a well-managed project. Greython's background in business management and education will enable her to update both the staff and guests of the hotel on the progress of the renovations. We have been browsing through the corporate database for ideas because we are constantly trying to shake things up and seize fresh opportunities. This is due to the fact that we have experience working with businesses across all industries. We can pursue other interests because we have a lot of free time. Our experience and knowledge enable us to take on challenging projects and seize intriguing opportunities. If all goes according to plan, output ought to soar. We can ensure that every single one of our clients will receive nothing less than exceptional service in this way. Never abandon the trust that the building's original designers, architects, or owners placed in it. As a result of everyone's unwavering support, our business has expanded. Our business's ability to comply with these terms will determine whether it succeeds or fails.

Hotel owners can leverage our substantial construction knowledge, innovative design concepts, and complete project management to accomplish their long-term goals. This new information is truly wowing the hotel industry. We have the power to alter the direction of the hotel industry right now. Hotels can readily acquire cutting-edge features with our assistance. Companies can benefit from providing a wider variety of housing options to their clients. A significant change is about to occur in the hotel industry. Therefore, it makes sense to focus on the expanding tourism market. The aim of the present lobby makeover was to give an homage to the past. Enhancing the lobby's appearance can be accomplished quickly and easily by painting the walls a different color or adding new flooring, lighting, and fixtures. In my opinion, the foyer captures the essence of the structure. Knowing that the amenities will be available during the entry upgrades gives guests peace of mind.

[greython5f]

Hotel renovation company

Like the rest of California, San Diego has seen a surge in the hotel sector in recent years. Like the rest of California, San Diego has seen an increase in mid-range and luxury hotels. This general contractor in San Diego serves lodging and tourism-related companies. The San Diego office's bottom line greatly depends on the hotel sector. We primarily concentrate on the greater San Diego region. The whole San Diego region, including its suburbs and downtown, is included in our service area.

Hotel renovation company

Understanding the needs of the owner and the hotel industry are essential for a successful repair. Should you choose a business without the requisite experience, things might not proceed as planned. If you stay hidden, your chances of surviving are much higher. If they are unable to suggest any excellent hotels in the vicinity, I would advise carrying on with your search. Not many applicants have brought up the company's culture. Only the most deserving individuals from around the globe are asked to join exclusive groups. Many things are going to happen.

Our versatility enables us to collaborate with any international hotel brand. We think that if we implement our approach, we will be better able to capitalize on unforeseen opportunities. There are many different service providers, and they are all essentially the same. Everything is handled by us, including insurance claims, maintenance, and building. Numerous examples demonstrate their worth. It would be useless to list all that we have accomplished. Greython Construction's stellar reputation is primarily due to the dedication and expertise of its workforce. Overall, these initiatives have also produced encouraging outcomes. We promise that every single one of our guests will be treated with the utmost care and respect due to the extensive expertise and training of our staff in the hospitality field. We are equipped to handle any issue that may arise during hotel construction or renovation. hotel refurbishment business As more and more businesses—both old and new—invest in renovations, the demand for hotel services has increased dramatically. Their distinct perspectives would be beneficial for both conventional and unconventional methods of hotel maintenance. They switch between the two environments with ease. To keep up with the growing demand, an increasing number of hotel constructions are underway. The main cause is the rise in demand for their services in both the public and private sectors. One factor is the closeness to many five-star hotels. There should be a crew member on board with experience building or renovating hotels. Due to their larger life experience base, older individuals are more capable of handling challenging activities. This is primarily due to how versatile their skills are. I am more than capable of transferring my knowledge from one environment to another.

A peaceful environment perfect for unwinding could be in store for guests at the Greython Hotel. Do not be afraid to stop by if you're having a bad day. Most likely, you are in the ideal location. The elegant dining rooms of the Greython are perfect for a formal event such as this one.

The hotel's construction team has been stressing how important it is to finish the renovations before the busy season starts. Please get in touch with us if you need any more information on the construction of a hotel or similar establishment. This is essential to the business's survival. Prosperous construction firms understand the importance of having a plan and following it. Greython will notify the hotel workers and guests of any updates pertaining to the renovations because of her experience in corporate administration. Since we are ready to adjust to shifting conditions and seize opportunities as they present themselves throughout the project, we have searched the company's database for relevant concepts. This is a result of our extensive background collaborating with companies in a variety of industries. We have so much spare time now that we can explore other interests. Because of our extensive knowledge and expertise, we have taken on difficult jobs and maximized fantastic chances. Our output will grow considerably if we mean what we say. We guarantee that every one of our clients will receive excellent service when using this strategy. Always maintain the faith of the building's original designers, architects, and owners. Without your constant support, we would not have been able to expand. Your capacity to accept these terms is crucial to the smooth operation of our business.

We provide hotel owners with our in-depth understanding of the construction sector, creative design concepts, and meticulous project management to assist them in reaching their long-term objectives. This will be welcomed by the hotel business. We can now control how the hotel business develops since we have the upper hand. We facilitate hotels' provision of contemporary amenities to visitors. Businesses gain by providing a greater selection of housing options to their clientele. The hospitality sector is going to undergo a radical transformation. Since the tourism industry is growing quickly, it makes sense to concentrate on fortifying ties with it. The organization's past and present were taken into account throughout the current lobby renovation. A different color for the walls or new flooring, fixtures, and lighting could be added to the lobby to modernize its decor. It's reasonable to presume that the entire building is agog if the lobby is. Although the entryway is currently being renovated, visitors won't experience any issues entering or leaving the facility as normal.

[thesproutpr]

Public Relations Firm | The Sprout PR Elevate your brand with a leading public relations firm. They manage media relations, handle crises, and execute strategic communications to enhance public images and build strong audience relationships.

[greython0975]

Greython Construction

Complete Instructions for Constructing the Greython

Greython Construction provides a wide range of services, including general contracting, design/build, O&M, and construction management, among others construction company near me The term "construction" encompasses the whole building process according to this interpretation. This general category includes a wide variety of locations, such as hotels, resorts, townhomes, and condominiums.

We have the resources to swiftly resolve any issue you may be facing.

We collaborate to learn the thoughts of the owners' design teams. These adjustments raise the project's value while lowering the risk's probability.

We have helped a lot of families locate homes because we are really committed and we pay close attention to detail. You need to give it your all if you want to come out on top. Surprisingly, Greython Building has become a household name across the nation and has climbed to the top of the building industry. The expansion of its consumer base has consistently been its utmost focus.

Spending less and saving more are two of the many possible advantages of a better schedule.

Everyone who helped make this possible has my deepest gratitude. We serve a wide variety of clients, from sole proprietorships to multinational conglomerates and beyond. We are capable of handling any job, no matter how big or small. All the way through the building process, the principles of lean construction are upheld. Three tenets form the basis of lean construction: timely project completion, enhanced understanding and fulfillment of customer objectives, and reduction of waste. In the building business, we have complete backing for our idea. Assuring happy clients is lean construction's first priority. Implementing the tenets of Lean Construction will help you achieve better project outcomes. Possible positive outcomes include more work being completed as planned, satisfied clients, reduced costs, and increased productivity from contractors. All of these possibilities are still well within the realm of possibility. All of these options continue to spark debate.

Be very careful when handling this. "Sir Arthur Henry Arthur" is the correct way to greet a lord such as Arthur Tudor.

Things were very different in those days! If we put our minds to anything, we can't back down.

A person for whom aesthetically pleasing homes, restaurants, hotels, and public spaces are works of art.

An excellent illustration of this is the American company Greython Construction. Their expertise in general contracting and project management allows them to effectively represent the owners and see the job through to completion. These solutions are useful for homeowners and business owners alike.

Get in touch with Greython right away. Whenever this is considered, my stomach drops.

Any reliable contractors you may know, please share their names and contact details with us. If you could be of any help, I would be forever indebted to you. We assure you that we will respond promptly to your inquiry, regardless of whether we are temporarily unable to contact the individual you have asked.

Any authority's legitimacy is open to question at any moment.

States served by Greython Construction range from New York and Saint Lucia to Saint Johns and Saint Louis as well as Mystic and Connecticut. There is no legitimate claim to these territories from any country other than the United States. The bulk of these communities are owned by the United States federal government. Among the many building and construction-related services they provide to local clients is traditional project management. Many potential places came to mind, including New York City, Saint Lucia, Saint Louis, Missouri, Saint Lucia, Saint Lucia, California, Los Angeles, San Diego, and an endless number of others. Among the popular options is Saint Lucia. If you are looking for a dependable construction company to build your house, company, apartment, or café, your search ends with Greython Building. That is why the group's recent accomplishments have garnered so much praise. Among our several competitive advantages is the concept that ideas can only be realized via the use of straightforward, uncomplicated language. On top of that, we follow all rules and pay close attention to detail to ensure that our customers get excellent service. In light of this, further demonstrations are required.

Please be cautious, as we are here to help. By using this strategy, we were able to maintain our concentration on the current task. You have all you need to embark on an exciting and challenging quest with the aid of Greython Building. An expert in the field of construction can identify that specific issue. You may take advantage of the many opportunities for growth and success that are available to you with our help. If everyone follows the rules, then everything should be well. We promise to do the project on time and within budget, just the way you want it done. When you want professional advice, a committed crew, and exceptional outcomes, there is only one name to remember: Greython Construction. Our carefully selected agents will not stop until they have completed the task you assigned them, regardless of the expense. Because of their stellar reputation, you can have complete trust in their abilities.

Among the many services offered by Graython Construction are design-build and owner's representative. Hotel, resort, business, single-family home, and apartment complexes are just a few of the many building types included in their vast portfolio. You can trust their abilities due to their extensive experience in the construction industry.

[newcodesociety]

Job Opening: Graphic Designer | Remote

Full Description and application here.

Job Title:  Graphic Designer Important note: This is for a visual design position, NOT a UX Specialist position. Candidate must have strong graphic design skills, including experience creating infographics.

Application Deadline:  January 22, 2024

Location:  Worldwide

About NN/g: Nielsen Norman Group (NN/g) is a UX consultancy trusted by leading organizations world-wide to provide reliable guidance on user experience. NN/g provides evidence-based UX insights in the form of research findings in articles, in-depth training, and consulting. 

We’re a small, fully remote company (fewer than 40 people, currently). We believe deeply in our mission to help the world learn about UX, and enjoy working with our curious and passionate coworkers. Once or twice a year, we travel to a fun location to spend time together in-person and discuss ideas to improve our work and our company. (Our most recent offsite locations include Jackson Hole and San Diego.)

When we hire people, they tend to stick around for a while. Our average employee retention is 7 years.  

Role Description: We’re looking for a talented graphic designer to join our small design team. You’ll work with a group of designers to translate complex concepts into visualizations that help our audience learn about UX. 

We’re looking for someone with: 

Very strong visual and conceptual design skills

At least some knowledge of UX

The ability and willingness to collaborate with UX researchers 

Our new teammate will work on: 

Data visualizations 

Creating templates for graphs and charts

Concept visualizations and infographics 

Book design and visuals

Typesetting 

Storyboarding  

Responsibilities:

Grasping in-progress UX concepts and exploring methods for visually representing them

Understanding constraints, requirements, and considerations of deliverables 

Sketching concepts to communicate ideas

Collaborating with authors, researchers, other designers, and videographers to improve visualizations

Producing high-fidelity, polished outputs: icons, infographics, and posters 

Designing a visual system for physical publications 

Exploring new tools, including artificial image generation  

Qualifications:

A minimum of 3 years of professional experience in graphic design (or visual design), UX, or similar field

A degree in design: graphic design, visual design, interaction design, communication design, or a related design discipline

Strong visual design skills: color, typography, imagery, and iconography

Excellent ability to translate research insights and frameworks into a consumable, compelling visual  

Able to seek input, iterate, and quickly adapt to feedback

Advanced proficiency in the Adobe Creative Suite

Fluent in English (advanced business proficiency)

Available to work during US timezones  

Application Process: 

Submit your resume and portfolio in our application form

Design exercise #1 

1-2 interviews 

Design exercise #2

Final interview  

Compensation & Perks: Base pay is just one component of NN/g’s total compensation. Salary will range from 65k - 100k USD based on experience and location. We're committed to ensuring competitive salary and benefits that are aligned with each country's requirements. These benefits are for U.S. employees and may vary to comply with local rules.

Position benefits include:

401(k) with employer contributions

ESOP (Employee Stock Ownership Plan)

HSA (Health Savings Account)

Health benefits

Paid parental leave

Flexible work arrangements

Performance bonuses  

We are committed to fostering an inclusive, discrimination-free environment where every staff member’s distinctive contributions are valued. We support diversity and inclusivity in our workplace, and reject discrimination based on race, religion, nationality, gender identity, sexual orientation, age, marital status, veteran status, or disability.

[superiorasphalt]

Description: Established in 1969, Superior Asphalt is a San Diego-based asphalt contractor specializing in paving, repair, sealcoating, striping, and resurfacing. With over five decades of experience, the company is committed to providing top-quality workmanship, exceptional customer service, and eco-friendly practices. Their team of licensed and insured professionals utilizes advanced techniques and equipment to deliver durable, long-lasting asphalt solutions for residential, commercial, and industrial projects.

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Address: 10159 Buena Vista Ave, Santee, CA 92071, USA

Business Phone: +16195714324

Email: info@superiorasphalt.com

Website: https://superiorasphaltsd.com

GBP listing: https://www.google.com/maps?cid=8920837094361380946

Coordinates: 32.8347183,-116.9758831

Plus Code: R2MF+VJ Santee, California, USA

Serving Areas: https://www.google.com/maps/d/viewer?mid=1FSWR-GnXQiCOnbGzMAhnWXztEQPOJtg&ll=32.83539447550811,-116.97588&z=10

Facebook: https://www.facebook.com/profile.php?id=61555193968111

Pinterest: https://www.pinterest.com/sandiegosuperiorasphalt

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Instagram: https://www.instagram.com/superior_asphalt_sd

YouTube Geotagged Video: https://youtu.be/7BDKyaiFR58