#Preventing Disease

[happycareclinicnursingservice]

Chronic diseases, such as diabetes, hypertension, and heart disease, require ongoing care and attention. Patients benefit significantly from dedicated healthcare services in Frederick, Maryland. Access to comprehensive care ensures that chronic conditions are managed proactively, reducing complications and improving the quality of life.

[meirimerens]

youtube shorts is just tiktok without being on the app the amount of "i'm a [qualification] and [misinformation]" could make one turn their skin inside-out in protest. "i'm a board-certified OB-GYN & it's only been about the last hundred years that women have actually experienced menopause. We didn't live long enough to experience it" how can you be so incredibly wrong about something so integral to your practice. King of the Hittites Hattusilis III was told in 1250 BCE that his sister was too old to reproduce at age 50+. Aristotle wrote in the 4th century BCE that women stopped menstruating between ages 40 to 50, common menopause ages today still. i cannot begin to tell you how 4th century & 1250 BCE don't really count as "the last hundred years" unless that -s is doing a lot of heavy lifting. waiter waiter more misinformation laws.

[reasonsforhope]

"Since it was first identified in 1983, HIV has infected more than 85 million people and caused some 40 million deaths worldwide.

While medication known as pre-exposure prophylaxis, or PrEP, can significantly reduce the risk of getting HIV, it has to be taken every day to be effective. A vaccine to provide lasting protection has eluded researchers for decades. Now, there may finally be a viable strategy for making one.

An experimental vaccine developed at Duke University triggered an elusive type of broadly neutralizing antibody in a small group of people enrolled in a 2019 clinical trial. The findings were published today [May 17, 2024] in the scientific journal Cell.

“This is one of the most pivotal studies in the HIV vaccine field to date,” says Glenda Gray, an HIV expert and the president and CEO of the South African Medical Research Council, who was not involved in the study.

A few years ago, a team from Scripps Research and the International AIDS Vaccine Initiative (IAVI) showed that it was possible to stimulate the precursor cells needed to make these rare antibodies in people. The Duke study goes a step further to generate these antibodies, albeit at low levels.

“This is a scientific feat and gives the field great hope that one can construct an HIV vaccine regimen that directs the immune response along a path that is required for protection,” Gray says.

-via WIRED, May 17, 2024. Article continues below.

Vaccines work by training the immune system to recognize a virus or other pathogen. They introduce something that looks like the virus—a piece of it, for example, or a weakened version of it—and by doing so, spur the body’s B cells into producing protective antibodies against it. Those antibodies stick around so that when a person later encounters the real virus, the immune system remembers and is poised to attack.

While researchers were able to produce Covid-19 vaccines in a matter of months, creating a vaccine against HIV has proven much more challenging. The problem is the unique nature of the virus. HIV mutates rapidly, meaning it can quickly outmaneuver immune defenses. It also integrates into the human genome within a few days of exposure, hiding out from the immune system.

“Parts of the virus look like our own cells, and we don’t like to make antibodies against our own selves,” says Barton Haynes, director of the Duke Human Vaccine Institute and one of the authors on the paper.

The particular antibodies that researchers are interested in are known as broadly neutralizing antibodies, which can recognize and block different versions of the virus. Because of HIV’s shape-shifting nature, there are two main types of HIV and each has several strains. An effective vaccine will need to target many of them.

Some HIV-infected individuals generate broadly neutralizing antibodies, although it often takes years of living with HIV to do so, Haynes says. Even then, people don’t make enough of them to fight off the virus. These special antibodies are made by unusual B cells that are loaded with mutations they’ve acquired over time in reaction to the virus changing inside the body. “These are weird antibodies,” Haynes says. “The body doesn’t make them easily.”

Haynes and his colleagues aimed to speed up that process in healthy, HIV-negative people. Their vaccine uses synthetic molecules that mimic a part of HIV’s outer coat, or envelope, called the membrane proximal external region. This area remains stable even as the virus mutates. Antibodies against this region can block many circulating strains of HIV.

The trial enrolled 20 healthy participants who were HIV-negative. Of those, 15 people received two of four planned doses of the investigational vaccine, and five received three doses. The trial was halted when one participant experienced an allergic reaction that was not life-threatening. The team found that the reaction was likely due to an additive in the vaccine, which they plan to remove in future testing.

Still, they found that two doses of the vaccine were enough to induce low levels of broadly neutralizing antibodies within a few weeks. Notably, B cells seemed to remain in a state of development to allow them to continue acquiring mutations, so they could evolve along with the virus. Researchers tested the antibodies on HIV samples in the lab and found that they were able to neutralize between 15 and 35 percent of them.

Jeffrey Laurence, a scientific consultant at the Foundation for AIDS Research (amfAR) and a professor of medicine at Weill Cornell Medical College, says the findings represent a step forward, but that challenges remain. “It outlines a path for vaccine development, but there’s a lot of work that needs to be done,” he says.

For one, he says, a vaccine would need to generate antibody levels that are significantly higher and able to neutralize with greater efficacy. He also says a one-dose vaccine would be ideal. “If you’re ever going to have a vaccine that’s helpful to the world, you’re going to need one dose,” he says.

Targeting more regions of the virus envelope could produce a more robust response. Haynes says the next step is designing a vaccine with at least three components, all aimed at distinct regions of the virus. The goal is to guide the B cells to become much stronger neutralizers, Haynes says. “We’re going to move forward and build on what we have learned.”

-via WIRED, May 17, 2024

[leona-florianova]

No, Jayce...What the fuck...He was dying of terminal illnes at like 30... Terminal illness caused by all the pollution in Zaun (Piltover mining operations, The Grey, the sewer system) .. What he really wanted was at least little bit more time to figure out and prevent the cause... To help the people of Zaun that work n live in the fissures...

But that part of Viktors character was lost at this point so whatever

Anyway... whats up.. S2 was very hollow.

[watermelinoe]

it's men it's men it's men the problem is men

[serpentface]

SPIRITUAL POLLUTION, THE GESTURES AGAINST EVIL, AND ABLUTION: A POST

The concepts of spiritual purity and pollution are central to the Faith of the Seven Faced God (and similar takes on the concept predate it throughout and beyond the immediate Wardi cultural sphere). There is no clean cut distinction between physical and spiritual health in this belief system (these concepts exist as a heavily overlapping venn diagram) and many methods intended to cleanse spiritual pollution address both realms.

The word for the concept referred to as spiritual pollution is 'mesechitse', which can translate to 'blockage' or 'severance' depending on the context (its underlying meaning is a pathway that has been stopped in some capacity).

At its core, spiritual pollution is a corruption of the living spirit (which is carried by/IS the blood). It causes both physical and spiritual problems. Polluted blood flows improperly and does not maintain the body’s natural stasis or integrity, causing or allowing disease or other bodily dysfunctions to occur. Many ailments are seen as wholly physical and internal in nature, occurring directly due to polluted blood flowing improperly and affecting key organs. Other diseases (particularly contagious or infectious disease) are known to be caused by dagi, which are harmful spirits that enter the body through orifices or wounds. A limited number of ailments (most notably pronounced schizophrenia-spectrum disorders or cognitive disabilities, unfortunately) are thought to be caused by possession by more powerful evil spirits.

At its worst, severe spiritual pollution is thought to impact or sever one's connection to God. Summarized very basically, severe pollution = blockage of flow between one's own living spirit and the greater spirit of God, which deprives a person of God's blessings and protection, severs them from the natural cycling of life and death (and prevents their necessary participation) and can put their afterlife in jeopardy.

Some degree of corruption to the living spirit is seen as completely inevitable and managed by the body, which physically expels some polluting agents via urine and feces, as well as menstruation (thus all of these substances are themselves dirty and polluting agents). It is reckoned as impossible for any living body to exist in a Completely spiritually pure state. The goal of cleansing (and broader practices revolving around spiritual integrity) is rather to maintain stasis of the body's natural cycling (and by extension a connection to God's living spirit) and to keep pollution contained and minimized.

If one's immortal soul successfully reaches the afterlife, it is then reborn into a spiritually pure existence incapable of being 'severed' from God in any capacity. God Itself is a spiritually pure being, but Its body and living spirit (the world and its cycles, manifested as Faces) is vulnerable. The purity of God's living spirit (and therefore the life-sustaining functions of the world that all beings depend upon) must be sustained, protected, and restored through right practice, which is what much what the public religion revolves around.

Spiritual pollution is a separate but overlapping concept with:

-Metaphysical vulnerability, the word for which is 'namne couyibase' (literally ‘lacking integrity of Being’). This is a state in which the body and living spirit is considered vulnerable to great change, for good or for bad. These states can have vital and positive uses (they are utilized in many rituals, and it is what allows for conception and birth), but must be entered with caution and intentionality. Uncontrolled namne couyibase can otherwise leave one open to forms of spiritual harm. -Curses, which are targeted infliction of harm (of all sorts- bad luck, evil spirits, etc) onto a person, place, or thing. A spiritually polluted body is has less resistance to curses, and curses can intensify this pollution. -Possession, which is when evil spirits attach themselves to or inhabit the body. In the vast majority of cases, possession does not mean an evil spirit is Controlling the body, merely harming it. A spiritually polluted body has less resistance to possession, and possession can intensify this pollution. -Ritual uncleanliness, which is a state of intensified spiritual pollution that requires complete prohibition from a person from entering sacred spaces or participating in certain rituals until they are made clean. The most common reasons for ritual uncleanliness are active menstruation, being in the mourning period, or having performed a known dirtying action without its required ablution (see below).

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Multiple levels of religious-medical practice are centered around maintaining the body's stasis and cleansing it of mesechitse whenever possible. The methods are both active and passive.

Passive methods include the wearing of protective objects/amulets or having the motifs on household items or as decoration (the most ubiquitous are charms like the pelatoche (lit: '(ocean) eye') or odatochent (lit. 'Gods eyes'), the skimmer woman, or phalluses, and the wearing of gull feathers), in addition to other beneficial/protective iconography (guardian lions are most common, though physical representations of each Face of God have beneficial functions).

Active methods cover a broad swath of rites and behaviors (which is even broader in non-doctrinal folk practices). I'll be focusing here on the two main everyday methods of protection/cleansing (rather than more specialized rites) that are supported by core doctrine and may be performed by anyone, rather than being restricted to priests.

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Gestures against evil

These are the absolute most basic protection methods, comprised of three core gestures.

Purity of intent: the hand is held with the palm facing upward, the pointer and pinky finger extended and the thumb and inner two fingers pressed together. This is the most directly ‘cleansing�� gesture, it attempts to bind uncleanliness within the body and thus to prevent inevitable background level spiritual pollution from the body infecting a pure environment or another person. You mostly perform this gesture while entering/leaving a protected or vulnerable space (literal or figurative).

Protection of spirit: the hand is held with the first two fingers pointed together, held upwards for generalized use or pointed for directed use. This is the simplest of apotropaic gestures, aiming to protect the body and spirit from outside harm. This is commonly used before or while entering contexts seen as physically and/or spiritually dangerous, or to un-aggressively counter an evil eye curse.

Dispelling of evil: The hand is held with the first two fingers pointing together, touched to the lips, and flicked away from the body. In practice, this is most commonly used to prevent attachment by malicious or otherwise harmful spirits that may have been evoked (you might perform this after you speak of someone believed to be an earthbound ghost or refer to an evil spirit directly, or immediately after touching a potentially contagious sick person (ideally followed by ablution)). This will not help you if evil spirits have fully Attached themselves to you, but can remove ones that have been attracted to you. Doing this gesture and flicking in the direction of another person is very rude.

These gestures have separate uses, but will often be performed in conjunction (usually in the order given) as a quick means of protecting oneself and the spaces around them. It is not considered a doctrinal replacement for ablution as it does not actually cleanse the spirit, but it attempts to reduce harm (both sustained and produced by the user).

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Ablutions:

Ablution is spiritually and physically cleansing the body with clean water. The metric for clean water is fairly expansive- ocean water, any flowing water, any clear lake, shallow water sources that are clear and free of (obvious) polluting elements such as animal corpses or unclean animal feces, any clear collected water.

The core requirement of an ablution is for the hands to be cleaned in all circumstances, and for other body parts to be cleansed in addition if the situation requires it. One must fully wet the hands/other affected areas and scrub thoroughly, and then use fresh water to rinse. If you have to clean other parts of your body, you save your hands for last (as they will be used for the cleaning).

It is appropriate to perform ablutions cooperatively, but the person assisting you should participate as well (ie- if you have someone washing your back, they should scrub and rinse their own hands after). Someone considered to be in a ritually unclean state that ablution will not immediately fix (the most common are actively menstruating or being in the midst of the mourning period) should not perform ablutions on others.

Note that there is no Hard distinction between bathing for spiritual cleanliness and bathing for physical cleanliness (there is a separate set of cultural standards for physical hygiene, but most hygiene expectations are Covered by ablution). In most circumstances, ablution is just a regular, sometimes tedious everyday activity rather than a solemn or special occasion.

The ritualized requirements denote that only the hands + any given affected body parts Must be washed, but ablutions will often be an aspect of a full-body bathing routine to meet other hygiene standards. (ie: someone performing ablution before making offerings or eating a meal is only Required to wash their hands, but will very often wash their whole bodies and clean their hair- offerings and a meal are (typically) daily activities, so this is a good time to just get a full bath in while you’re at it). It may additionally involve washing the skin with oil or soap, moisturizing the hair with oil, scraping away dead skin, and applying perfumes. This is not a ritual requirement and is performed because generally, people like to feel clean and smell nice.

The hard physicality of cleansing WITH WATER is KEY to this practice. Per core doctrine, there are no DIY cleansing methods that replace washing with water. If one does not have access to clean water for ablutions, they should not perform offerings whatsoever (but are allowed to pray) until they can be cleansed, and accept that they are receiving spiritual pollution by performing ablution-required tasks in the meantime. A blessing from a priest is the only doctrine-supported spiritually cleansing replacement for water ablutions. In practice many people will use the gestures against evil as a replacement (which is not supported by doctrine and is more common in folk religious practice), and virtually everyone will find ways to get physical contaminants off of their body either way (if you step in dog shit and don't have any water nearby, you're going to wipe it the hell off even if that doesn't make you ritually clean).

Times when such an ablution is generally considered a hard requirement:

Before bloodletting in prayer or making other offerings

Before meals

Before assisting in a birth

After menstruation ends

After receiving penetrative sex

After defecating

After urinating (this isn't as ubiquitously seen as a hard requirement, in a lot of cases people interpret it as 'only if you actually get pee on your hands')

After touching urine

After touching feces (many lines of thought make exceptions for the excrement of cattle and khait due to their clean and sacred status- this makes life a easier for the majority of people who have to use dry dung as fuel)

After touching a dead body (human or animal)

At the end of your mourning period for dead kin (traditionally as part of a larger ritual involving full body submergence in flowing water, rather than as a common ablution)

After touching someone else's blood (aside from rites that require it, in which the blood is expected to be clean and the cross-pollution of living spirit is intentional) (technically includes semen but this does not come up very often)

After touching most sick people (particularly with contagious diseases or any skin ailments)

After recovering from an illness (ablutions will be performed as an aspect of treatment as well)

Before entering most temple's inner shrines (and some temples altogether)

Also a requirement for participation in certain specific rites and/or festivals

The exact nuances on how hard these requirements are sometimes vary, particularly in instances revolving around touch. Official doctrine is that any unclean touch requires ablution, but in common practice this is sometimes reinterpreted as only a hard requirement when the touch occurs to the hands. Most practitioners do not perform an ablution immediately after an unclean touch occurs (if you're a field laborer and step in dung, you're probably going to wait to wash until you retire for the night), and not everyone performs ablutions every single time they 'should'.

Only drawing I have related to ablution under the cut (nudity)

This is one way to do it

[juniper-clan]

When did the baby get so wise???

Longpaw??? Great intelligence but what??? /pos

[todaysdocument]

Draft Report [on Tuskegee Syphilis Study]

Record Group 442: Records of the Centers for Disease Control and PreventionSeries: Tuskegee Syphilis Study Administrative Records

-1- 10-8-49.

Alabama Untreated Syphilis Study

[handwritten] "Progression of Abnormalities over 16 yrs"? [/handwritten]

This paper is the fourth of a series of studies of untreated acquired syphilis in the male Negro in Macon County, Alabama. Previous papers [checkmark with "Ref" handwritten above] have health with ["^ (1)" handwritten] the [crossed out] extend of morbidity [/crossed out] ["various abnormalities found" handwritten above] in untreated syphilitics [crossed out] in comparison with [/crossed out] ["and" handwritten above] nonsyphilitic controls, ["at the time of the initial examination" handwritten above] the life expectancy of the respective groups ["after 10 yrs observation." handwritten to the right of the typewritten line] ["^ (2)" handwritten] the natural history of syphilis, uninfluenced by treatment, with special attention to [crossed out] its [/crossed out] ["the" handwritten above] effect ["^of the disease" handwritten above] on the cardiovascular system ["-after 5 yrs observation and" handwritten above]. The present study is a[crossed out "n"] ["^report made after 16 years observation and is an" handwritten above]attempt to estimate the ["- increment of abnormalities" handwritten below] [crossed out] progressive disability [/crossed out] among untreated syphilitics and nonsyphilitic controls ["-recurring during that 16 yr. period" handwritten below] [crossed out] during 16 years of observation. [/crossed out]

How are these different? [handwritten at right side with "HaK" circled below]

The original study population selected during ( the winter [crossed out] seasons [/crossed out] ["months" handwritten above] of) 1931-32 and 1932-33 consisted of 410 syphilitics and 201 ["^controls presumably" handwritten above] nonsyphilitic [crossed out] controls [/crossed out], all of [crossed out] which [/crossed out] ["whom ?" handwritten above] were 25 years of age or ["^older" handwritten above] [illegible text crossed out]. [crossed out] The individuals were carefully selected.[/crossed out] The presence or absence of syphilitic infection was based on personal history, physical examination, and serologic tests on the blood. [crossed out] Before the present far reaching aims of the study were actually set up, 179 [/crossed out] Of the syphilitic group ["^179" handwritten above] were given some treatment for their infection during the

What was the study pop. selected for??? [handwritten at the right with "HaK" circled below]

To be referenced a specific page in this paper. [handwritten at the right, signed "KHZ" below]-2-

period of this first examination. Most of these individuals were among the younger age groups, and were given amounts of treatment varying from 1 to 15 shots of neoarsephenamine. ["-These have been dropped from consideration in the present paper" handwritten above] A second complete physical examination was made of the majority of the group in 1938-39. [crossed out] However, no strenuous effort was made to locate those who received treatment, and consequently a large number of them lapsed from observation. [/crossed out] Since 1939, there has been an annual visit to Macon County by a physician for the purpose of obtaining specimens of blood for serologic examination. In the fall of 1948 a third physical examination was performed on the individuals who could be located at that time, [crossed out] again with no particular emphasis on those who had received some treatment. [/crossed out]

An important phase of the study has been the performance of autopsies on the individuals who have died. Through 1948, [crossed out] 163 [/crossed out] ["140" handwritten above] of the number included in the original population have died, and of these [crossed out] 111 [/crossed out] ["98" handwritten above] have been autopsied. Of those on whom [crossed out] have not been autopsied [/crossed out] ["autopsies have not been performed," handwritten above] proof of death has been established by death certificate or by information furnished by relatives or friends of the deceased. Because of the relatively non-migratory nature of the group, it is reasonably certain that there have been no other deaths than the [crossed out] 163 [/crossed out] ["140" handwritten above] recorded. No analysis of autopsy data will be attempted in this report; a detailed account of this

[thebookishwallflower]

I want to make a post to inform people about the current situation with the bird flu (/avian flu/H5N1) outbreaks.

I don't want to cause panic but do want to spread information.

This is especially important if you live in an area that has a news system you don't trust to give accurate, timely, or honest news about something like a possible new pandemic, use your own judgement.

If that applies it is going to be very important to make sure you stay informed and follow these H5N1 outbreaks yourself and know how to best protect yourself.

I am no expert, but I do know a good bit about disease and influenza in particular, and have been following the H5N1 outbreaks as they've been happening, so under the cut I'm going to do my best to inform everyone I can.

Please stay safe, stay informed, and spread information, not germs.

What's bird flu and why do I care? (What's bird flu and why do I care?)

Avian flu and bird flu mean the same thing, an influenza virus that (primarily) infects birds. H5N1 denotes a specific strain of avian influenza. H5N1 can spillover (when a pathogen spreads from it's normal host organism to a new host organism) from animals to humans.

How could I get H5N1? (How could I get H5N1?)

Human to human transmission has not been observed yet (12/1/24) during this current outbreak. You can get this from contact with wild birds, especially water fowl, domestic birds, cattle, pigs, horses, dogs, and bats. It is also possible to get from raw (unpasteurized) milk and undercooked meat from infected animals.

What's the big deal then? (What's the big deal then?)

The common flu is not very pathogenic. How pathogenic something is determines how sick something makes the host, something that is highly pathogenic can cause severe disease. H5N1 is considered a HPAI, Highly Pathogenic Avian Influenza.

H5N1 is also a Type A influenza virus, most known Type A influenza viruses can infect birds. There is one Type A human flu in circulation at the moment, however it isn't very prevalent.

"IAV poses a significant risk of zoonotic infection, host switch, and the generation of pandemic viruses. IAVs can infect humans and a variety of animals, such as pigs, horses, marine mammals, cats, dogs, and birds (S1)."

IAV - Influenza A Viruses | Zoonotic infection - when an infectious disease of a non-human host infects a human host | Host switch - when a cross-species transmission of a pathogen can lead to successful, stable, and continuous infections

Every species the flu infects, the more strains that pop up under a sub-type IAV, the possibility for recombination increases. "Recombination occurs when at least two viral genomes [or strains] co-infect the same host cell and exchange genetic segments (S2)."

The flu is pretty good at recombination, when given the chance. It is also really good at mutating, and fast. If there were to be a recombination event and a new strain evolved (this would be called an antigenic shift) that was highly pathogenic, highly infectious (good at spreading, which H5N1 is), that could then infect humans and cause human-to-human transmission we might have a pandemic on our hands. This has not shown signs of happening during this outbreak*, this is what to look out for.

This (a recombination event) is what caused the 1918 pandemic during WW1. This pandemic killed an estimated 50 to 100 million people in 1918, in a world with a population of around 2 billion. 7.1 million died of COVID 19, as of 11/9/24 (S3), from a population of around 8 billion.

We know more, we are prepared, it's not guaranteed to happen, and it's not guaranteed to be as bad. But the possibilities are endless and it's extremely important to be prepared and stay informed.

So what do I do? (So what do I do?)

Again, stay informed, and that might mean checking independent news sources, the CDC website, and more, to keep yourself updated, especially if you know your local news won't do it for you. You should also familiarize yourself with the symptoms of influenza, if you have it, stay home.

Keep yourself safe, we had a pandemic already, you know the drill. Cover your nose and mouth when sneezing/coughing, wash your hands, sanitize your hands, and get your flu shot. And, in addition, avoid contact with wild birds, poultry, pigs, and cattle if you can.

In the event that this gets worse, social distancing is very important, being outdoors, wearing a mask, and all the stuff above, you can shed the virus for around a week before you start feeling bad. Keep yourself safe and don't infect anyone else.

If that doesn't sound like it'll do much, I promise you it does. Those are all classified NPI's (non-pharmaceutical interventions) and even epidemiologists were shocked at their impact and importance during the COVID-19 pandemic. They did work, and they were incredibly effective—as long as they were carried out.

I don't want to cause panic or worry anyone, but that is how information ends of suppressed. I want to make everyone aware of what we might face so that we can fight it and be strong and stay safe.

If anyone has any questions, wants any clarification, any corrections, or wants to know some good places to learn more about this stuff please don't hesitate to contact me (@'s, dm's, or asks), I will answer as best I can.

Here's the CDC's page covering the H5 bird flu current situation.

S1 - https://pmc.ncbi.nlm.nih.gov/articles/PMC5578040/

S2 - https://pmc.ncbi.nlm.nih.gov/articles/PMC7106159/

S3 - https://data.who.int/dashboards/covid19/deaths?n=c

*with the exception of this coverage (as a possibility): https://www.theguardian.com/world/2024/nov/19/bird-flu-cases-mutation-canada

[threepoint14art]

FELIZ CUMPLEAÑOS A EAKKKKKKKK

[kittenquasar]

Why do people look at me more when I wear a mask? It's like they see this gender ambiguous body and assume the "worst" is under the mask and treat me weird. Like girl I'm pretty and you are out of pocket for treating me bad because i don't want to bring covid home (or because I have stubble heh). I've gotten more colds/flus in the past two years than I got in the preceeding like 8! People are gross and covid is airborne now! Wear a mask when it's busy! It isn't hard I just wish people didn't treat me worse for wearing one :(

[cluescorner]

Arlecchino's whole deal is unbelievable

Arlecchino: Huh I wonder what's causing my weird powers? I can't really worry about that right now tho, I've gotta become King and then kill my "Mother".

*Kills Clervie and "Mother"*

Arlecchino: Huh I wonder why I was able to defeat a Fatui Harbinger when I'm like 17 or so? I can't really worry about that right now tho, I've gotta be in jail and become a Harbinger.

*Is in jail for a while and becomes a Harbinger*

Arlecchino: Huh I wonder why I am-

Pierro: Hey what's up hello, anyways you're descended from the Crimson Moon Dynasty of Khaenri'ah. I'm sure that this is a lot for you to take in so-

Arlecchino: Ok.

Pierro: ...You're just cool with that?

Arlecchino: IDK maybe? I can't really worry about that at the moment, I'm a father now. This orphanage full of children I love (who also are child soldiers and are not allowed to leave or else I'll execute them except maybe now I'm just gonna wipe their memories IDK I'm morally complex) isn't gonna run itself.

*Runs the orphanage/spy recruitment initiative*

Me, the fucking player: WHAT DO YOU MEAN YOU ARE KHAENRI'AN? WHY WASN'T THIS BROUGHT UP IN YOUR FUCKING QUEST?? OR ANYTHING ELSE????

Arlecchino, talking to me through my phone: I honestly don't know why you care, I'm too busy to give a shit. Anyways, I'm gonna go fight fate itself I guess. I'm sure that I don't share any thematic parallels with any other Khaenri'an characters (particularly as it relates to acting and family angst) and that I haven't made the idea of 'curses' on Khaenri'ans and what they entail even more complicated than they already were. See ya.

[reasonsforhope]

Cancer

“Starting at home, a study last year found that US cancer deaths had declined by 33% since 1991. This is equivalent to around 3.8 million people alive thanks to various efforts to combat the disease family.

The report was authored by the American Cancer Society, and published in the journal CA. American Cancer Society CEO Karen Knudsen called the drop “truly formidable,” while the report attributed the fall to the development of better treatments, the reduction in smoking habits, and earlier detection methods.

Just between 2019 and 2020, cancer death rates dropped 1.5%, while the deployment of the HPV vaccine was correlated with a 65% drop in cervical cancer rates from 2012 through 2019 among women in their 30s.

The report also found that not only are death rates falling, but 5-year survival rates for detected cancers have increased 68% among all diagnoses made between 2012 and 2018.

Guinea Worm Disease

Cancer research often involves cutting edge medical research, but across West Africa and India where cutting edge medicine is not widely available, human determination has succeeded in nearly eradicating Guinea Worm disease.

There are records of this truly unpleasant parasite affecting human health going back thousands of years, and in 1989, there were nearly 1 million cases globally.

But in 2022, this unwelcome waterborne guest created just 15 cases worldwide—a decline of 99.998%, and almost all 15 of those cases occurred in Chad.

This monumental turnaround was not the result of some experimental vaccine, but simple education, teaching people how to avoid drinking contaminated water, when and where this mostly seasonal parasite is likely to be found, and how to treat water to purify it of the Guinea worm.

Ebola

Other than Chad, Guinea Worm disease was also found in Uganda, which produced another medical milestone with the successful eradication of a recent Ebola outbreak.

The outbreak began in September, driven on by the incurable Sudan strain of the virus. It was the worst outbreak in 20 years, but even though there is no vaccine for the Sudan strain, the health authorities managed to contain it to just two administrative districts, and 142 confirmed cases.

“The magic bullet has been our communities who understood the importance of doing what was needed to end the outbreak, and took action,” said health minister Dr. Jane Ruth Aceng Ocero last Wednesday.

Vaccine trials involving Oxford University are currently underway for the Sudan strain, but until that time, health authorities received congratulations for their swift actions, and were thanked for the “lessons learned.””

-via Good News Network, 1/19/23

[ricisidro]

The Centers for Disease Control and Prevention (CDC) vaccine advisory group today recommended a second 2024-25 COVID-19 vaccine dose, spaced 6 months apart, for people ages 65 and older and for people in younger age-groups who have moderate or severe immunocompromising conditions.

The group also recommended an extra dose, three or more, in people with immunocompromising conditions.

#SARSCOV2 #COVID19

https://www.cidrap.umn.edu/covid-19/cdc-vaccine-advisers-recommend-second-covid-vaccine-dose-seniors-immune-compromised

[eatclean-bewhole]

[alwaysbewoke]

nice. of course the k-12 education system is underfunded, leading to constant teacher shortages, inadequate facilities, and subpar student outcomes. healthcare access is alarmingly poor, with an unneeded high uninsured rate that leaves many without normal, essential medical services, and even with recent medicaid expansion, mad issues still remain. health outcomes are fckn dismal, with high rates of chronic diseases and preventable deaths. obesity levels are among the worst in the nation (no wonder with all the food insecurity and lack of healthy lifestyle options around there). income inequality is out of control. they got many of their citizens living in poverty with almost zero prospects for improvement. on top of these issues, oklahoma has one of the highest incarceration rates in the country, driven by harsh sentencing laws and systemic failings which targets black and poor (because of course (because america)). all on top of a legacy of racial injustices. i mean the tulsa race massacre. need i say more? but yea they should totally spend 1bil on entertainment. that's a totally reasonable thing to do smfh.