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1. Pendapatan Boleh Guna Bersih (PBGB) ialah jumlah wang yang boleh dibelanjakan atau disimpan oleh individu atau isi rumah selepas ditolak cukai pendapatan. Ia juga dikenali sebagai Pendapatan Peribadi Boleh Guna (PPBG).
2. Pendapatan Budi Bicara (PBB) ialah jumlah baki pendapatan yang tinggal selepas semua keperluan hidup diambilkira..
3. Nisbah Keupayaan Membayar Hutang (NKMH) ialah ukuran aliran tunai yang tersedia untuk kewajiban membayar hutang semasa. NKMH mengukur aliran tunai perniagaan berbanding keupayaan membayar hutangnya.
4. Nilai Bersih (NB) ialah nilai aset individu ditolak liabilitinya. Ia merupakan ukuran penting kesihatan kewangan kerana ia memberikan gambaran kedudukan kewangan semasa individu.
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lindseyfoard · 2 years
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Un bistro charmant. Might have to print this one. ❤️ (at Paris, France) https://www.instagram.com/p/CpiYMr-pPBg/?igshid=NGJjMDIxMWI=
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rabchunter · 2 years
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Last night I had the greatest honour to attend my dear friend and bro KT Preceptory, Marc was installing the EKT that was following on from him, what a magnificent ceremony and one I am so glad I did not miss.
I was also there playing my part as the PPBG with my fellow Bodyguard KTs, a wonderful bunch of great men and Freemasons, we had such a jolly time as always at the festive board or after meeting as it's known.
I am so looking forward to attending my own preceptory coming up and catching up with these wonderful fellows, I have to say KT is one of my all time favourite orders within Freemasonry 💪🙏🛡️⚔️🧔🥇 www.somersetkt.org
#somersetfreemasonry #kt #knightstemplars #knightstemplar #somersetknightstemplar #freemasonrysomerset #freemason #theolehedgecreeper #freemasonry
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leiajoydesign · 2 years
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Bibliography
Wednesday 30th November 2022
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dizzyG2696. (2022) Detailed Trip Report on 200ug of LSD. Reddit. [online]. 2 September. Available from: https://www.reddit.com/r/Psychedelics/comments/x45oet/detailed_trip_report_on_200ug_of_lsd/ [Accessed 7 October 2022]
SuperReeseP_Soog. (2022) 2g psilocybin and 600ug LSD Trip Report. Reddit. [online]. 9 August. Available from: https://www.reddit.com/r/Psychedelics/comments/wjsyof/2g_psilocybin_and_600ug_lsd_trip_report_beauty/ [Accessed 7 October 2022]
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Steven Van (2019). 5 TRIPPY Music Video Effects - NO PLUGINS! (Premiere Pro CC Tutorial). [online]. Available from: https://www.youtube.com/watch?v=On2EiNgfvpQ&list=PLcx7mvJoa0s8Gqmf5OVmzxzJczZu9Bk7Y&index=13 [Accessed 8 October 2022].
SoundEffectsFactory (2013). Male Deep / Heavy Breathing Sound Effect. [online]. Available from: https://www.youtube.com/watch?v=U3frQdGaJiY [Accessed 9 October 2022].
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John Kensy Music (Unknown). Meditation/Spiritual Music MP3 Download. [online]. Available from: https://pixabay.com/music/search/genre/meditation/spiritual/ [Accessed 9 October 2022].
Piero Zagami (Unknown). Market Cafe Magazine - A zine about data visualization. [online]. Available from: https://pierozagami.com/market-cafe-magazine-a-zine-about-data-visualization [Accessed 16 October 2022].
Gerry Leonidas (2013). The Origin of ‘Adhesion’. [online]. Available from: https://leonidas.net/2013/04/03/the-origin-of-adhesion/ [Accessed 21 October 2022].
Heller, S. Talarico, L. (2012). Typography Sketchbooks. Thames & Hudson Ltd. [Accessed 21 October 2022]
McNeil, P. (2017). The Visual History of Type. Laurence King Publishing Ltd. [Accessed 21 October 2022]
British Beauty Council (Unknown). PACKAGING. [online]. Available from: https://britishbeautycouncil.com/ppbg/packaging/ [Accessed 15 November 2022].
Inside Packaging (Unknown). How can the beauty industry reduce plastic waste? [online]. Available from: https://inside-packaging.nridigital.com/packaging_jul21/beauty_packaging_plastic_waste [Accessed 15 November 2022].
Plastic Pollution Coalition (2022). The Ugly Side of Beauty: The Cosmetics Industry’s Plastic Packaging Problem.[online]. Available from: https://www.plasticpollutioncoalition.org/blog/2022/1/25/the-ugly-side-of-beauty-the-cosmetics-industrys-plastic-packaging-problem [Accessed 15 November 2022].
Glamour (2022). How the beauty industry is tackling the ocean plastic problem, plus the brands making a change.[online]. Available from: https://www.glamourmagazine.co.uk/article/ocean-plastic-waste-beauty-industry [Accessed 15 November 2022].
Lush (Unkown). BRING IT BACK - Our new-look recycling scheme. [online]. Available from: https://www.lush.com/uk/en/a/bring-it-back-our-new-look-recycling-scheme [Accessed 16 November 2022].
The Body Shop (Unkown). OUR RECYCLING SCHEME. [online]. Available from: https://www.thebodyshop.com/en-gb/about-us/brand-values/sustainability/return-recycle-reuse/a/a00011 [Accessed 16 November 2022].
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Alexandra Black Bug Creation ********(2022). Cynthia. Branding. Packaging. [online]. Available from: https://www.behance.net/gallery/137445643/Cynthia-Branding-Packaging?tracking_source=search_projects|cosmetic+packaging [Accessed 18 November 2022].
Elshafiey, M. Labib, M (2022). NURA Branding & Packaging. [online]. Available from: https://www.behance.net/gallery/141875085/NURA-Branding-Packaging?tracking_source=search_projects|cosmetic+packaging [Accessed 18 November 2022].
Al Asif, A. (2022). Ombré | Branding and Packaging. [online]. Available from: https://www.behance.net/gallery/141179639/Ombr-Branding-and-Packaging?tracking_source=search_projects|cosmetic+packaging [Accessed 18 November 2022].
Fernandes, R. (2022). seed'it - semeie a si mesmo. [online]. Available from: https://www.behance.net/gallery/145613973/seedit-semeie-a-si-mesmo?tracking_source=search_projects|cosmetic+packaging [Accessed 18 November 2022].
Bouliane, N. (2022). The Pfand system: how to return bottles in Germany. [online]. Available from: https://allaboutberlin.com/guides/pfand-bottles [Accessed 20 November 2022].
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the-kipsabian · 6 years
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Some Asagao!Mads ship doodles
I heard you weren’t doing great and wanted to make you a cute. But if you look closely, you can tell the exact points I got tired and gave up.
Hope you’re doing a tad better when you see this x
dsaSDNSAKDASNDKAS I WANNA YELL SO BADLY RIGHT NOW THESE ARE SO FFFREAKING CUTE??? oh my god my dude these are absolutely precious, gosh look at all these sweet beans aaaAAAAA also my god i have a lot of ships and ZERO REGRETS LOL
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Pterocarpus marsupium and Gymnema Sylvestre Powder in Alleviation of Biochemical Abnormalities Associated with Human Type 2 Diabetes Mellitus- Juniper Publishers
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Abstract
Objectives: This observational study investigated the antihyperglycemic, antihyperlipidemic and antioxidant potential of Pterocarpus marsupium (Vijaysaar) and Gymnema sylvestre (Gudmar) (“VG”) Therapy in patients with type 2 diabetes mellitus.
Methods: Subjects with type 2 diabetes mellitus were administered a phytochemical formulation consisting 50 ml of aqueous extract derived from 3 gm “VG” powder was administered twice a day for six months. The blood glucose levels were monitored at monthly intervals; glycosylated hemoglobin, lipid profile and biomarkers of oxidative stress, liver and kidney functions were monitored at three monthly intervals.
Results: Daily administration of the “VG” Therapy regularly for 6 months resulted in significant reduction of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in high-density lipoprotein cholesterol levels with concomitant decrease in total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein levels. Significant improvement in the biochemical markers of oxidative stress was recorded.
Conclusion: TThe results suggest that herbal formulation “VG” is beneficial in improving glucose and lipid homeostasis in type 2 diabetics and may serve as an adjunct therapy.
Keywords: Hyperglycemia; Dyslipidemia; Oxidative stress; Type 2 diabetes mellitus; Pterocarpus marsupiu; Gymnema Sylvestre
Abbrevations: BMI: Body Mass Index; DBP: Diastolic Blood Pressure; FPG: Fasting Plasma Glucose; GSH: Reduced Glutathione; HbA1c: Glycosylated Haemoglobin; HDL: High-Density Lipoprotein Cholesterol; LDL: Low-Density Lipoprotein Cholesterol; PPG: Postprandial Glucose; SBP: Systolic Blood Pressure; SOD: Superoxide Dismutase; SGOT: Serum Glutamate Oxaloacetate Transaminase; SGPT: Serum Glutamate Pyruvate Transaminase; TBARS: Thiobarbituric Acid Reacting Substances; VLDL: Very low-density lipoprotein cholesterol; VG: Vijaysaar and Gurmar
Introduction
Type 2 diabetes mellitus is reaching epidemic proportions worldwide and is a complex metabolic disorder characterized by hyperglycemia and dysregulated lipid metabolism [1,2]. Abdominal obesity and dyslipidemia (increased triglycerides, high LDL-cholesterol and low HDL-cholesterol), and hypertension, as well as altered platelet function [3] are the major risk factors contributing to type 2 diabetes. The metabolic defects that underlie the development of type 2 diabetes may include islet β-cells dysfunction, hyperglucagonemia, elevated endogenous glucose production, development of peripheral insulin resistance, inflammation of adipose tissue, and dysregulation of adipokines production [4]. Chronic elevation of blood glucose which is a central factor in the production of reactive oxygen species (ROS) [5] which in turn promote cellular damage and contribute to the development and progression of diabetic complications, such as cardiovascular disease, nephropathy, retinal blindness, neuropathy, and peripheral gangrene [6]. The conventional allopathic drugs, sulfonylureas, meglitinides, biguanides, metformin, thiazolidinediones, miglitol, acarbose, etc. although effective [7], are associated with minor or major side effects on long term use [8]. Statins used in the treatment of dyslipidemia have their own limitations [9].
Plant based Indian traditional medicines such as Ayurveda have been used since ancient times in the treatment of diabetes [10]. Ethnobotanical studies of traditional herbal medicine used for diabetes have identified more than 1,200 species of plants with hypoglycemic activity [10]. Medicinal plants are frequently considered to be less toxic and free from side effects than synthetic ones. The antidiabetic effects of several plant extracts and herbal formulations and their bioactive compounds have been identified and characterized for the treatment of diabetes mellitus [11,12].
Polyherbal formulations [13], have been shown to exhibit antidiabetic, antihyperlipidemic and antioxidant potential in animal models as well as in diabetic patients [14]. The phytochemical based formulations consisting of multiple herbs are liable to produce a large number of metabolites that may act on multiple targets in the body and hence, polyherbal formulations (Which are used in traditional practice) are preferred over mono therapeutic ones. Although, phytochemical based formulations have extensively been used, studies on their proof of efficacy are limited [15].
Gymnema sylvestre (Gudmar) is a climber grown in tropical forests of South-East and belongs to the family Asclepiadaceae G. sylvestre is considered to have a great anti-diabetic potential and used in several anti-diabetic formulations. There are several reports in animal models as well as in diabetic patients which shows that extract of G. sylvestre leaves have anti-diabetic potential [16,17], and these effects are attributes due to increase in insulin secretion [18]. Pterocarpus marsupium (Vijaysaar) is the most versatile plant with a wide spectrum of biological activities and belongs to the family Fabaceae. The P. marsupium is reported to be anti-diabetic and associated with anti-obesity, anti-hyperlipidemic, antiinflammatory, anti-oxidative, antitumorigenic functions [19-21]. The aim of this study is to explore the therapeutic potential of combined effects of the regular consumption of Pterocarpus marsupium and Gymnema sylvestre in human subjects with type 2 diabetes mellitus.
Materials and Methods
Study sample
A total of 45 type 2 diabetic patients attending the weekend diabetes clinic run by the Centre for Translational Research, School of Studies in Biochemistry, Jiwaji University, India expressed their willingness to participate in the study. Of these, 35subjects met the inclusion criteria who were then explained the necessity of maintaining defined lifestyle pattern during the course of the study. Out of 35 subjects, 8 subjects were eliminated during the course of the study due to non-compliance. The remaining 27 subjects took the drug regimen regularly as per the experimental design. Figure 1 shows the number of subjects enrolled and drop outs during the course of study. The patients’ baseline characteristics are summarized in (Table 1).
Data are expressed as Mean ± SEM;
BMI-Body mass index; SBP- Systolic blood pressure; DBP- Diastolic blood pressure; FBG-Fasting blood glucose; PPBG-Post prandial blood glucose; HbA1c: Glycosylated Haemoglobin.
Study design
The study design included following steps:
a) Selection of patients meeting inclusion criteria and those consented to participate in the study.
b) Measurement of anthropometric and biochemical parameters once before and at selected intervals during the course of the study.
c) Administration of “VG” Therapy in defined dose daily for a period of 6 months.
d) Measurement of parameters at the end of the study.
e) Analysis of the data.
Inclusion criteria
a) Non-insulin dependent diabetes diagnosed, as per the criteria of the World Health Organization;
b) Both genders between the ages of 30-65 years;
c) Body Mass Index in the range of 18.5 to 40;
d) Participants who understood the benefits of the study and signed a written informed consent;
Exclusion criteria
a) Presently using other blood glucose regulating agents;
b) Daily intake of alcoholic beverages;
c) Smokers consuming more than 1 pack/day;
d) Patients diagnosed as type I and insulin dependent type II diabetics;
e) Patients with hepatic or renal disease, pancreatitis, cardiac problems, uncontrolled hypertension, malnutrition and severe immune deficiency.
f) Non-compliance during the course of study.
Before starting the study all participating subjects were given a verbal explanation about the objectives of the study, nature of drug formulation (Kwath) to be consumed daily, (“VG” Therapy) rationale and duration of therapy in local language. They were asked to avoid a carbohydrate rich diet and advised regular walking for about 4-5 km during the course of study. The patients who consented to participate in the study were registered, anthropometric measurements; weight, height and waist were recorded at the beginning and at selected intervals during the study period. The patients were kept exclusively on “VG” therapy.
Composition of drug (VG) formulation
The “VG” formulation consisted of a mixture of Pterocarpus marsupium (Vijaysaar), and Gymnema sylvestre (Gurmar) (Table 2) and was provided by the M/S Dindayal Industries Ltd. India. The individual plants were identified by Prof. A.K. Jain, School of Studies Botany, Institute of Ethnobiology Jiwaji University Gwalior. Voucher specimens were prepared and deposited at the Centre (IOE-501 and IOE-505).
Composition of VG formulation: 1:1.
Preparation of VG kwath
3 gm of VG powder was suspended in 100 ml drinking water, kept overnight, boiled till 50% water is evaporated, cooled to room temperature and consumed on an empty stomach twice a day for six months under the supervision of an Ayurvedic Physician.
Biochemical parameters
The fasting and postprandial plasma glucose levels were monitored at monthly intervals, while the glycosylated hemoglobin (HbA1c), biomarkers of oxidative stress viz., Superoxide dismutase (SOD), catalase, reduced glutathione (GSH), Thiobarbituric Acid Reactive Substances (TBARS) and lipid profile, biochemical markers of kidney and liver functions were monitored at baseline, at the middle (3 month) and at the end (6 month) of the therapy.
Fasting and postprandial plasma glucose was estimated by the Glucose oxidase/Peroxidase method [22]. Glycosylated hemoglobin (HbA1c) was estimated by the ion exchange resin method [23]. Estimation of plasma total cholesterol by the Cholesterol oxidase Phenolaminophenazone CHOD-PAP method [24], triglyceride by GPO-PAP method [25], High density lipoprotein cholesterol (HDL) by Polyethylene glycol/CHOD-PAP method [26], Low-density lipoprotein cholesterol (LDL) and Very-low density lipoprotein cholesterol (VLDL) were calculated by the Friedewald formula, urea by the modified Berthelot method [27], uric acid by uricase/PAP method [28], creatinine by modified Jaffe’s kinetic method [29], Alanine transaminase (SGPT or ALT) and serum Aspertate transaminase (SGOT or AST) by the modified International Federation of Clinical Chemistry method [30], and bilirubin by method of L. Jendrassik [31] was assayed using standard kits from Crest Biosystems, Goa (India). Markers of oxidative stress such as super oxide dismutase (SOD) Winterbourn et al. [32], catalase by Sinha, [33], glutathione (GSH) Ellman et al. [34], and Thiobarbituric Acid Reactive Substances (TBARS) Ohkawa et al. [35] were checked.
Ethical clearance
The study protocol was duly approved by the Institutional Human Ethics Committee (JU/IHEC/2013-A/13).
Statistical analysis
Statistical analysis was carried out using a paired t test (Sigma stat 3.5). A p-value *p<0.05, **p<0.001 was considered statistically significant.
Results
Effect of VG therapy on hyper-glycemia
Table 3 shows the fasting and postprandial blood glucose levels at monthly intervals in subjects on “VG” therapy. A significant decrease was recorded for fasting (13.5% P<0.05), postprandial (15.0%, <0.001) glucose levels and glycosylated hemoglobin (9.8%) at the end of six months therapy.
Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values
HDL-High-density lipoprotein cholesterol; LDL-Low-density lipoprotein cholesterol; VLDL- Very- low density lipoprotein cholesterol; TC-Total cholesterol
Effect of VG therapy on lipidemia
Table 4 shows the results of the lipid profile of patients on “VG” therapy. Total cholesterol, triglycerides, LDL and VLDL were significantly decreased after six months therapy by 9.6%, 14.4%, 15.7%, and 14.4% respectively (P<0.05). HDL cholesterol was elevated from32.50±1.11 to 35.69 ± 1.02 (P<0.001).
Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values
HDL-High-density lipoprotein cholesterol; LDL-Low-density lipoprotein cholesterol; VLDL- Very- low density lipoprotein cholesterol; TC-Total cholesterol
Effect of VG therapy on biomarkers of oxidative stress
Significant (P<0.05, P<0.001), improvements in GSH level (from 1.98±0.17 to 2.59±0.21 mg/dl), SOD activity (from 0.63±0.05 to 0.94±0.08 μM/min/mg protein), catalase activity (from 7.64±0.24 to 9.44±0.23 μM/min/mg protein) were recorded. A significant decrease (P<0.001) in TBARS (from 457.19±8.09 to 415.15±7.47 (moles of Malondialdehyde/ml of blood) were recorded at the end of six months therapy.
Effect of VG therapy on markers of toxicity
The effect of “VG” therapy on kidney function was monitored by estimating urea, uric acid and creatinine levels in plasma at specified intervals during the course of therapy. The data presented in Table 5 showed significant (P<0.05), reductions in Urea (from 29.97±1.20 to 27.10±0.88mg/dl) and uric acid (from 5.08±0.20 to 4.67±0.20 mg/dl) and notable reduction in creatinine (from 0.78±0.06 to 0.73±0.05) at the end of six months therapy.
Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values
GSH: Reduced glutathione; SOD-Superoxide dismutase; TBARS- Thiobarbituric acid reacting substances.
Data are expressed as Mean ± SEM; *p<0.05; **p<0.001 compared to Base line values.
SGOT- Serum Glutamate Oxaloacetate Transaminase; SGPT- Serum Glutamate Pyruvate Transaminase.
Significant (P< 0.05), variations in biochemical markers of liver functions, namely bilirubin (from 0.83±0.06 to 0.70±0.04 mg/ml) and SGOT (from 22.47±1.61 to 18.00±1.04 IU/L) as well as SGPT (from 23.60±2.32 to 19.26±1.38 IU/L), at the end of six months was observed (Table 6).
Effect of VG therapy on hypertension and body mass index
Table 7 shows variations in systolic blood pressure (from 133.70±2.59 to 129.22±2.39 mmHg), diastolic blood pressure (from 81.70±0.97 to 79.56±0.93 mmHg) and body mass index (from 25.21±0.64 to 24.22±0.60 kg/m2) at the end of the six months therapy.
Discussion
Currently, plant based therapies (main or supplementary) are being used globally for the management of type 2 diabetes. In India, the indigenous systems of medicine viz., Ayurveda, Siddha & Unani employ plant based extracts for treatment of diabetes (Premeha in Ayurveda). Most of the Ayurveda based formulations depend on plants/herbs based decoctions, and powders. In the present study, administration of the aqueous extract of VG that consisted of equal amounts of the ingredients for over a period of 6 months to type 2 diabetic subjects resulted in significant improvements of altered biochemical markers. Significant alleviation in glucose homeostasis, as marked by noticeable changes in glycosylated hemoglobin, blood glucose levels, and lipid profile were observed. The G. sylvestre leaf extracts are reported to reduce hyperglycaemia in experimental animals [16], and human type II diabetics [17]. The G. sylvestre is reported to promote insulin secretion, probably by regeneration of pancreatic beta cells [17,18]. The gymnemagenin and gymnemic acids in G. sylvestre, showed to exhibit potent antioxidant, and hepatoprotective activities [36]. Ethanolic extract of G. sylvestre was reported to possess anti‑apoptotic potential in STZ‑induced diabetic cardiomyopathy, and affected the levels of leptin, insulin, dyslipidemia, apolipoproteins, lipids, LDH (serum lactate dehydrogenase) in experimental models [37]. Administration of deacylgymnemic acid DAGA (200mg/kg), a derivative of gymnemic acid reduced Systolic blood pressure and significantly improved the fasting plasma glucose and HOMA-IR (homeostatis model assessment insulin resistance) with marginal improvement in lipid profile [38]. The G. sylvestre is also reported to inhibit absorption of glucose from intestine. The atomic arrangement of gymnemic acid molecules is similar to that of glucose molecules and they reduce the blood glucose level by preventing the absorption of sugar molecule in the intestine. It is attributed by filling the receptor location in the absorptive external layer of the intestine by gymnemic acid molecules [39].
In a controlled study, an aqueous extract of the leaves of G. sylvestre, (GS4) when administered at the dose of 400mg/day, to subjects with insulin-dependent diabetes mellitus (IDDM), the insulin requirement came down together with fasting blood glucose, HbA1c and serum lipid levels soon after therapy. However, the GS4 administration failed to check glycosylated haemoglobin and glycosylated plasma protein levels on long term follow up. The GS4 therapy is reported to enhance insulin secretion rate, either by regeneration or revitalisation of the beta cells [40].
The effectiveness of GS4, further investigated as a supplementary drug to conventional oral anti-hyperglycemic drugs. Administration of GS4 (400mg/day) to 22 Type 2 diabetic patients receiving conventional therapy resulted in significant reductions in blood glucose and, glycosylated hemoglobin level. In addition, five of the 22 diabetic patients showed improved glycemic control with GS4 alone and were discontinue their conventional drug [17].
In another study, supplementation of the diet with G. sylvestre at the dose of 500 mg per day for a period of 3 months reduced polyphagia, fatigue, blood glucose levels with concurrent reductions in HbA1c, lipid profile suggesting beneficial effect of G. sylvestre supplementation in the management of diabetes mellitus [41].
Pterocarpus marsupium is traditionally used in Indian ayurvedic medicine for the treatment of diabetes and has been shown to control diabetes in experimental animals [42]. The phenolic C-glycosides present in P. marsupium regulated glucose homeostasis and significantly decreased the TNF-α level in experimental diabetes [43]. The phenolics, marsupsin, pterosupin, pterostilbene and (-)-epicatechin present in P. marsupium have been identified as the blood sugar lowering components [20,44].
The alcohol extract of the bark of P. marsupium Roxb shown to exhibit potent antidiabetic activity and corrected the metabolic alterations in diabetic rats [42]. Aqueous extracts of P. marsupium Linn significantly attenuated hyper insulinaemia as well as hypertriglyceridaemia and also prevented the alteration in metabolic patterns [45]. The Indian Council of Medical Research undertook an anti-diabetic phase II open trial at four centers across Indian using Vijaysar (Pterocarpus marsupium). Vijaysar was tested in newly-diagnosed or untreated non-insulin dependent diabetes mellitus (NIDDM) patients between 35 and 60 age for 12 weeks. Among the 93 patients who completed 12 wk of treatment, both the fasting and postprandial blood glucose levels fell significantly (P < 0.001), by 32 and 45mg/dl at 12 wk from the initial means of 151 and 216mg/dl respectively. Mean HbA1c Other laboratory parameters remained stable during the designated treatment period of 12 wk. Also, no side-effects were reported [46].
Our previous study done with the polyherbal formulation, “GSPF kwath” which contains Vijaysar and Gurmar as two of the ingredients has shown antidiabetic and antioxidative effects [13]. “GSPF kwath”, showed 23.5%, 26.7% and 11.7% reductions in fasting, postprandial blood glucose and HbA1c respectively. In the present study “VG” containing only two of the components of GSPF proved highly beneficial in restoring not only hyperglycemia but also lipidemia and antioxidative potential. The changes observed on glycemic, lipidemic and oxidative stress. Oral administration of “VG” therapy for 6 months had no adverse effects, either on kidney or liver functions and in fact showed a significant improvement in the functioning of these vital organs.
Conclusion
In conclusion, the “VG” administration to type 2 diabetic patients with varying degrees of glycemia, lipidemia and oxidative stress provide an efficient alternative to conventional antidiabetic drugs when coupled with active lifestyle and dietary changes. Significant decrease in biochemical markers viz., blood glucose, HbA1c, total cholesterol, triglycerides, LDL-cholesterol, and VLDL-cholesterol and higher values of HDL, following VG therapy are testimony to the anti-diabetic efficacy of VG. Further, the formulation did not show any adverse effects on liver and kidney functions and may be a potential natural and safe therapy for treatment and prevention of diabetic complications but randomized controlled trials are required to confirm these findings.
Acknowledgment
We thank M/S Dindayal Industries Ltd., Gwalior (M.P.) for the supply of the Vijaysaar and Gurmar powder and the financial support from AYUSH, New Delhi, (F.NO. Z.31014/02/2009/ EMR-CCARS) is duly acknowledged. We are grateful to all the human subjects who volunteered to participate in the study. Our profound thanks extend to colleagues of the laboratory and students for their unreserved support in conducting this study.
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pikasute · 7 years
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日刊アメーバニュース
極道牧師を知っていますか? 元暴力団員でも人生をやり直せる 日刊アメーバニュース 進藤さんは、刑務所で罪をつぐない、所属していた暴力団と関係を断ってから、キリスト教の伝道活動をおこなっている人物です。 覚せい剤の売人だった暗黒時代『極道牧師の辻説法』(進藤龍也・著/学研プラス・刊)という本があります。 前科7犯・服役3回という、元暴力団員の ...
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rabchunter · 2 years
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Last Night I had the greatest honour to attend St Keyna 455 Preceptory that meet in the Keynsham Temple here in the Province of Somersetshire, to see my good friend and Bro KT SB go through his Knight of Malta Ceremony ⚔️🛡️🧔💪🙏
I was also there as part of the PPBG for Somersetshire, we mustard up in good numbers too, be being The Late Knight as always all the Bodyguard duties were filled ⚔️🛡️💪
Ahhhh happy days just sit back and enjoy the ceremony or so I thought, the MS announced they need a volunteer to sit on the OCT Table, as my name echoed through the PPBG like a male voice choir, thanx boys, I actually really enjoyed taking part as I always do, especially as my very good friend EKT MC was heading it all up 🙏⚔️🛡️🧔💪
I will say the ceremony was absolutely fantastic and one of the very best Malta ⚔️ ceremonies I have ever seen, the festive board or after meeting as it's known was so jolly, the food wonderful and the wine exquisite, I was truly saddened when the evening ended for I enjoyed it so much amongst my Brother Knights 🙏💪⚔️🛡️🧔
I will say of all the degrees in Freemasonry this one of my true favourites 🙏 🛡️⚔️
Tuum in vinculis ordinis 💪🙏🛡️⚔️🧔
www.somersetfreemasons.org
somersetkt.org.uk
#somersetfreemasonry
#somersetfreemasons
#freemasonry #knightstemplar #knightsofmalta #knight #malta #kt #theolehedgecreeper.co.uk #stkeyna455 #stkeyna #preceptory #ugle #unitedgrandlodgeofengland
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the-kipsabian · 6 years
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At the end of rough days PBG will bring a cookies and either play animal intersection or binge Arter whilst cuddling Mads like a tiny Teddy bear
..the mental imagine i have in my head about this with peanut sitting under three blankets with mads in his lap, a cookie in his mouth and his chin on top of her head as hes trying to get a good look at his 4ds while they sit there playing animal intersection together as mads keeps yelling cause all the villagers are jusT SO HECKING CUTE LIKE PEANUT DID YOU SEE THIS BIRD HES ADORABLE I LOVE HIM
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rabchunter · 2 years
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WOW Massonically yet again last night another awesome Knights Templar meeting ⚔️🤺🙏🤠
Last night I had the pleasure nay honour to be a guest at OLOW The Bodyguards Preceptory here in the Province of Somersetshire, I was also there with my fellow Provincial Priors Bodyguards (PPBG) as our awesome Provincial Prior and Sub Prior was in attendance ⚔️🙏
EKt AC EP, wow lead his officers magnificently what a ceremony, quite simply first class, Bro KTs T & D were accepted as a member of the preceptory after a successful ballot ⚔️🤺🙏
EKt J lead a body of knights with the S of S and presented it in fine style to EKt AC and the OLOW Preceptory, this was really inspiring and a great job boys 💪🤠⚔️🤺🙏
EKt Fritz have a most enchanting talk about the TT KTs and finished to a momentous round of applause 🙏
The festive board or after meeting was so jolly and every man there happy to be in each other's company, the food was exquisite and the wine was very palatable, the speeches and toasts were excellent 🤺🙏⚔️
What a fantastic night spent with Good Friends, Masons and Bro Knights, I truly did not want the night to end 🤠🤺🙏⚔️
Knights Templar in Somersetshire' some of the finest Of the order I telle, I can't recommend KT highly to all MMs/Comps you will wish you had joined sooner I guarantee 💪🤠🤺🙏⚔️
http://somersetkt.org.uk/
www.somersetfreemasons.org
#knightstemplar #knighttemplars #knightsofmalta #theolehedgecreeper #somersetroyalarch #somersetknightstemplar #somersetfreemasonry #somersetfreemasons #masonic #freemason #freemasonry #unitedgrandlodgeofengland #ugle #freemasonrytoday
@pglsomerset @ugle
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rabchunter · 2 years
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Massonically Wow yet again yesterday, I had the privilege nay honour to attend The KT Preceptory Temple Combe 686 that meet in the Yatton Temple here in the Province of Somersetshire 🙏🤺
I was there as a personal guest of a dear friend and brother Knight 🤺 but also there because our Provincial Prior was there and I am part of his elite body gaurd (PPBG) a fine body of men I telle, good friends and Brother Knights 🙏🤺
The ceremony was first class, every officer performing their roles admirably, The PPBG Wow our A of Ss were so sharp and ceremonial drill was quite simply the best I have seen in the land, Somerset have one of the finest PPBGs, I feel truly humbled to be amongst such great men and Bro Knights 🙏🤺
Catching up with old friends and making new ones is also a great pleasure in freemasonry, the food exquisite, the wine 🍷 most excellent, the company simply the best 🙏🤺
The festive board or after meeting as it's known was jolly, inspirational and educational, the speeches and toasts were excellent too, alas the day had to end as always, I wish it would of lasted longer, I am looking forward to attending Keynsham Preceptory tonight to see so many friends until next time dear brother Knights 🙏 YITBOTO 🤺🙏💪
www.somersetfreemasonry
#somersetfreemasonry #somersetfreemasons #theolehedgecreeper #freemasonry #masonic #knightstemplar #knighttemplars #knightsofmalta #masonicknightstemplar #kt #templecombe #templecombe686 #yattonmasonictemple #unigitedgrandlodgeofengland #ugle #freemasonrytoday
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the-kipsabian · 8 years
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12 with Spacepixi >:3
12. “I loved you. Loved.” 
Helooked at her nervously over the desk, the blue haired girl not even noticingthe pair of hazel eyes basically staring at her. Jeff had gone through thismoment over in his head so many times he probably couldn’t even count that highif he tried, or at least he would have lost count about halfway through everytime, but now that it was looking him straight in the face, it still didn’t makegoing through with it any easier.
     “Hey?”
    The pair of gray eyestook a moment before they looked up from the notebook sitting on the desk infront of her, her hand finishing the word she was currently writing. Jeff wasn’texactly sure what she was working on, but he didn’t dare to ask. It wasn’t importantright now, maybe he could use it as a bailing plan B if the situation got toosticky for his liking and he had to quickly change the topic.
    “Yeah?”
    He wasstared back rather intensely, it was almost like Pixi was impatient with him.She didn’t sound like it, but her eyes were telling him a whole differentstory, traveling all over his face as if they were trying to find a point tolook at that made it less obvious how much she already missed the lines of thepages of her notebook.
    “I, uh,wanted to talk to you about something.”
    Well,that one was fairly obvious, seeing how they were the only two people sittingin the clubroom at the moment, half an hour before anyone else was scheduled toshow up. Pixi nodded, Jeff making a mental note how part of her bangs bouncedin front of her forehead a little. Had they always been that long?
    Hewatched as Pixi lowered the pen from her hand, slowly closing the notebook, effectivelytrapping the pen between the pages, before her eyes looked back up at him. Shealmost looked like she had been expecting this? But Jeff wasn’t thatpredictable, at least not with this… Right?
    “I’mgoing to assume you talked to Peanut?”
    Shit, didshe really already know? Jeff nodded slowly, watching as Pixi let out a longsigh before running a hand through her shorty, messy blue hair. After a moment,she nodded her head as well. “Well… Then you know.”
    Yes… Yes,he did know. Jeff was aware of the order things had gone down. How he had toldPBG how he felt about the blue girl sitting across the table from him. How PBGhad told him to go for it, Jeff pushing the thought off and leaving it at that.Maybe it would happen in the future.
    How PBGhad taken the matters into his own hands without telling anybody, trying tomake Jeff jealous enough to confess as he started to court his classmateinstead.
    Thingshas just went downhill from there. As far as Jeff knew, this was betrayal, andnothing more. He didn’t go for the girl, so his best friend did. For whatpurpose, he didn’t really know. All that was sure, is that after PBG starteddating her, the contact was broken.
    No moregame days together.
    No morepractice time together.
    No moreteam game in the soccer matched either.
    Up untilyesterday Jeff didn’t know why this happened. And after he learned that it wasfor his sake, it didn’t really make things any better. He had been kept in thedark about everything for so long, the revelation felt like it was made up onthe spot when PBG finally decided to tell him, months later, what was actuallygoing on.
    And thatsomewhere down the line he had actually fallen for the girl he knew his best friendalso had feelings for since the very beginning.
    “To behonest,” Pixi’s quiet voice cut his trail of thought, the pair of hazel eyesblinking Jeff back into reality as he noticed that he had stopped to stare the topof the blue hair across the desk as Pixi looked down at her notebook, herfingers tracing the imagines on its cover. Foxes, huh?
    “If youwould have told me first, I would have said yes. I loved you.”
    It took amoment for the words to hit in, Jeff’s eyes slowly widening.
    “You… Youdo?”
    “Loved.”She looked up, sending him a little smile as she straightened her back beforestanding up, grabbing the notebook with her. “It’s too late. I’m sorry, Jeff.”
    His mindstill registering her words, frozen on his seat Jeff watched as the girl flungher bag over her shoulder, giving him another apologetic smile before sheexited the clubroom.
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the-kipsabian · 8 years
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“fake dating” with asagao!pixi and pbg
its peanuts idea, cause he knows jeff like her so he wants to try to push him on to get jealous enough to confess to her i realized how much this sounds like the canon pbg route in the game oH BOY
but jeff is like a mixture of jealousy and being like ‘okay i like this girl but hes also my best friend and look how happy they are i dont wanna interfere’
and then nothing happens on his end and somewhere down the line peanut actually starts having real feelings in this “fake dating” scenario
to pixi its all real from the very beginning. like peanut doesnt fill her in that hes just playing along to push jeff into doing something, but shes down to date peanut when he asks cause why not. hes nice and a friend and sure she maybe feeling something for jeff but thats like never gonna happen so pfff i can go on a few dates with peanut and see what happens
its never more than possibly hand holding and snuggles, mostly cause pixi isnt comfortable and peanut is trying to keep it as civil as possible for the sake of jeff, but again somewhere down the line hes actually like ‘oh shit i might actually have feels for this girl??’
and mmmmm
ensue angst
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the-kipsabian · 5 years
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just because i'm still trying to learn asagao things, what are the mads ships? like friendships, romantic ships, whatever other ships there are. i just wanna know things ~
oooof we have. established so many things lemme see if i can even recall all of them anymore lol
as for romantic ships, therespixiefeathers (mads/kit)spaceharper (mads/jeff)pixietown (mads/luke)natemadness (mads/nate, tho atm this is an au only i believe? and its probably gonna be that way?)didyouknowmadness (mads/shane)sparkleharper (mads/jared)ppbg (mads/peebs)fictionbang (mads/dan)
friendships/bromances (i think this counts with ones that have like names for them cause. basically anyone within hidden block and normal boots no matter the timeline qualify for friendships tho? + all the other selfinserts ofc)assblastbros (mads & jimmy)pixiemoose (mads & ian)pixiecarus (mads & caddy)melancholy poets (mads & ayu)mads and arin doesnt have a name but that also exist i just. need to do something with it really lmao
as for other ships, the only one that comes to mind that qualifies for this is yungpixiefeathers? which is a poly ship for mads, kit and luke ~
im. fairly sure thats all? the only other thing asagao selfinsert related i have tagged in my blog outside of other selfinserts is pasta the cat but thats not a ship thing but a tag for one of the stray cats cause i havent tagged the rest cause pasta was the original one lol
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the-kipsabian · 8 years
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im gonna find the warmest hoodie i can from my closet and then im gonna make more tea and THEN im gonna write down some plans for my spaceharper
pls come yell at me on discord im gonna need emotional support for this
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pikasute · 7 years
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日刊アメーバニュース
極道牧師を知っていますか? 元暴力団員でも人生をやり直せる 日刊アメーバニュース 進藤さんは、刑務所で罪をつぐない、所属していた暴力団と関係を断ってから、キリスト教の伝道活動をおこなっている人物です。 覚せい剤の売人だった暗黒時代『極道牧師の辻説法』(進藤龍也・著/学研プラス・刊)という本があります。 前科7犯・服役3回という、元暴力団員の ...
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