#Organe

[deutschrapfinest]

Nichts zu bieten außer Spenderorgane.

Hand gebrochen - Crystal F

[vhscorp]

Mon organe le plus vital, c'est ton cœur...

V. H. SCORP

[uneonomatopee]

Tristesse Dimensions 17X22cm 145€ hors livraison Porcelaine froide / acrylique extra-fine - - - #uneonomatopée #anatomie #anatomy #cabinetdecuriosité #cabinetofcuriosities #organe #poumon #emotions #madeinfrance https://www.instagram.com/p/CnB7RScg_Ew/?igshid=NGJjMDIxMWI=

[nikitafauve]

[hualianisms]

verified ways to donate to gaza directly

[this post is outdated. up-to-date version here.]

Donate to a Palestinian family directly:

gazafunds.com - Donate directly to a Palestinian family in urgent need of evacuation, medical treatment, daily necessities or more. Site run by Palestinians, all GFMs verified (full list here). Spotlights 1 stagnant GFM at a time. (*If you can't decide who/where to donate, just go to gazafunds.com & donate to the 1 GFM they show you!)

masterlist of 200+ verified Palestinian families' GFMs: Operation Olive Branch

Help provide tents:

The Sameer Project: Currently providing tents & transport for families in Rafah who urgently need to evacuate to Deir Al Balah. Has a team on the ground in Gaza who have supplied tents to 1% of the displaced population in Rafah. Run by Palestinians. (paypal) (gfm)

@helpgazachildren: Currently helping Palestinians in a refugee camp in Rafah flee the Rafah invasion to Khan Younis. Funds go directly to Hussam, a Palestinian in Rafah who hosts a refugee camp. Funds will cover the cost of tents & transport fuel. Managed by a Palestinian @.fairuzfan. (gfm)

Food:

Care for Gaza: Palestinian charity on the ground in Gaza distributing food, cash, medicine & other essentials to displaced families. Proof of their work found on their Twitter. (paypal) (gfm)

We Feed Gaza: Team of Palestinian volunteers in the heart of Gaza distributing food & water to 344+ families. More details & proof in their gfm. Vetted & promoted by LetsTalkPalestine on IG. (gfm)

Direct Aid for Gaza: A Palestinian activist on the ground in Gaza distributing food, cash & other essential supplies to displaced families. Proof of their work found on their twitter. (paypal) (gfm)

Water (*urgent and crucial!)

Gaza Municipality: The official Municipality of Gaza is doing vital, life-saving work to rebuild the water pipes in Gaza City to restore access to clean water & waste management services for the people of Gaza.

eSIMs (*very urgent):

guide to buy & send esims to gaza

Crips for eSims for Gaza: donate any amount to this team of volunteers who pool funds to buy & maintain gaza esims regularly (see their financial accountability document).

Medical Aid:

Gaza Wound Care: Palestinian doctors in central Gaza treating injured/sick children & mothers in neglected displacement camps far from hospitals. Facing a severe shortage of medicines, equipment, and medical supplies. Currently raising funds to support their efforts to battle infectious diseases in refugee camps. (gfm) (paypal) (gogetfunding)

international charities: Palestine Red Crescent Society, Palestine Children's Relief Fund, Medical Aid for Palestinians

How to help if you can't donate:

Share & amplify Palestinian fundraisers in your irl & online circles

Organize or help to run an online/irl event to raise funds for Palestine

Boycott

Get involved with a protest/strike/direct action in your area

Contact your reps

Educate yourself & others both irl & online

Daily clicks on Arab.org

(you can even adopt 1 fundraiser campaign to regularly boost it & make materials promoting it online, or print posters/flyers about Palestinian fundraisers to encourage others to donate. (poster/graphic about gazafunds.com: here, flyers about esims: here, flyers about gazafamilyfunds: here)

(longer masterpost of all ways you can help)

(*all these links and more now in this rentry page. will no longer be updating this post, instead refer to the rentry page)

Last updated 3/6/2024 with Gaza Wound Care & We Feed Gaza. Wanted to focus on Palestinian-run grassroots initiatives that will actually reach Gazans on the ground, so all of these except eSIMs, PCRF, MAP are by Palestinians. Donating to international orgs is not ideal rn as aid is still being stopped at the border. Please focus on Palestinian-run initiatives on the ground in Gaza.

Remember, small donations really do add up. Any amount counts, even $1!

[aromanticduck]

There's wholesome ships and there's toxic ships, but I'd like to coin 'sodium chloride ships', where the individuals involved are both horrible and dangerous people, but somehow being together renders them surprisingly well-adjusted (if a little salty).

[pnkrathian]

i feel like the knowledge that there are some medical databases with free-to-use 3D scans of various human organs available for 3D printing would have drastically reduced tumblrs amount of bone stealing scandals. plus you can make ones that glow in the dark.

look at my glow in the dark humerus boy

[flango87]

FUCK YEAH COLUMBIA UNI STUDENTS!!!!!!

[angelicgarnet]

the way people online talk about autism is getting really weird, like do they know that neurotypicals still have interests? that someone being passionate about a hobby doesn't mean they're autistic? you guys know that right

[sadclowncentral]

seething about the fact that i will never experience photosynthesis in my own useless cells. i bet it feels so good when the light of the sun both warms you and fuels you at the same time. a bone-deep satisfaction mixed with a heated sugar-rush and endless brightness. not that i would fucking know

[visenyaism]

seven years ago in the name of tolerating free speech from all political perspectives my nasty ass evil university let an army of tiki torch wielding nazis shouting jews will not replace us march through grounds threatening the lives of students and community members with zero police presence. and today they retroactively changed campus policy around tents so they could send in the cops to bust up the gaza memorial vigil. genuinely fucking stomach turning

[peggycatrerr]

today on the train home the guy next to me was on his phone and at one point i saw him go on tumblr and he just had like. a normie dash. like it was all photography. of nature and architecture. he was using tumblr the way a heterosexual landscaper for rich people might use instagram. i actually had to watch his screen for a few seconds to be sure it really was tumblr because i was so taken aback by the content he was viewing. this is why algorithmless websites are so beautiful btw because i genuinely didn't know that this side of tumblr even existed. he didn't even so much as scroll past any text posts.

EDIT: look i'm not going to turn off reblogs but i cannot stress enough that THIS WASN'T A HIPSTER BLOG DASH IT WASN'T AN AESTHETIC BLOG DASH IT WAS THE MOST WILDLY GENERIC COLLECTION OF IMAGES YOU HAVE EVER SEEN IN YOUR LIFE. I AM NOT EXAGGERATING OR BEING A QUIRKY FANDOM TUMBLRINA WHEN I SAY "NORMIE" I GENUINELY MEAN "SO NORMAL THAT IT CIRCLES AROUND TO WEIRD". CAN ANYBODY HEAR ME? HELLO?

[inkskinned]

i got rickrolled today but it didn't work because i have adblocker installed, so youtube just told me i violated the terms of service. yesterday i was trying to edit a picture as a joke for my girlfriend, and google made me check a box to prove i'm human because i wasn't "searching normally".

it isn't just that capitalism is killing fun and whimsy, it is that any element of entertainment or joy is being fed upon by this mosquito body, one that will suck you dry at any vulnerability.

do you want to meet new friends in your city? download this app, visit our website, sign up for our email list. pay for this class on making a terrarium, on candlemaking, on cooking. it will be 90 dollars a session. you can go to group fitness, but only under our specific gym membership. solve the puzzle, sign up for our puzzle-of-the-month-club. what is a club if not just a paid opportunity - you are all paying for the same thing, which makes you a community.

but you're like me, i know it - you're careful, you try the library meetings and the stuff at the local school and all of that. the problem is that you kind of want really specific opportunities that used to exist. you are so grateful for libraries and the publicly-funded things: they are, however, an exception - and everything they have, they've fought tooth-and-nail to protect. you read a headline about how in many other states, libraries have virtually nothing left.

do you want to meet up with your friends afterwards? gift your friends the discord app. you can choose to go to a cafe (buy a coffee, at least), a bar (money, alcohol) or you can all stay in and catch a movie (streaming) or you can all stay in bed (rent. don't get me started) and scream (noise complaint. ticket at least).

you want to read a new book, but the book has to have 124 buzzwords from tiktok readers that are, like, weirdly horny. you can purchase this audiobook on audible! your podcast isn't on spotify, it's on its own server, pay for a different site. fuck, at least you're supporting artists you like. the art museum just raised their ticket price. once, they had a temporary exhibit that acknowledged that ~85% of their permanent art galleries were from cis white men, and that they had thousands of works by women (even famous women, like frida! georgia o'keefe!) just rotting in their basement. that exhibit lasted for 3 months and then they put everything away again.

walmart proudly supports this strip of land by the street! here are some flowers with wilting leaves. its employees have to pay out-of-pocket for their uniforms. my friend once got fined by the city because she organized a community pick-up of the riverfront, which was technically private property.

no, you cannot afford to take that dance class, neither can i. by the way - i'm a teacher. i'm absolutely not saying "educators shouldn't be paid fairly." i'm saying that when i taught classes, renting a studio went from 20 bucks an hour to 180 in the span of 6 months. no significant changes to the studio were made, except they now list the place as updated and friendly. the heat still doesn't work in the building. i have literally never seen the landlord who ignores my emails. recently they've been renting it out at night as an "unusual nightclub; a once-in-a-lifetime close-knit party." they spent some of those 180 dollars on LEDs and called it renovating. the high heels they invite in have been ruining the marley.

do you want to experience the old internet? do you want to play flash games or get back the temporary joy of club penguin? you can, you just need to pay for it. i have a weird, neurodivergent obsession with occasionally checking in to watch the downfall and NFT-ification of neopets. if i'm honest with you all - i never got into webkins, my family didn't have the money to buy me a pointless elephant. people forget that "being poor" can mean literally "if i buy you that toy, i can't afford rent."

you and i don't have time to make good food, and we don't have the budget for it. we are not gonna be able to host dinner parties, we're not made of money, kid. do you want some kind of 3rd space? a space that isn't home or work or school? you could try being online, but - what places actually exist for you? tiktok counts as social media because you see other people on it, not because they actually talk to you.

there was a local winter tradition of sledding down the hill at my school. kids would use pizza boxes and jackets and whatever worked, howling and laughing. back in september, they made a big announcement that this time, rules were changing, and everyone must pay 10 dollars to participate. when im not scared shitless, i kind of appreciate the environmental irony - it hasn't gone below 40. so much for snow & joyriding.

i saw a bulletin for a local dogwalking group and, nervous about making a good first impression, showed up early. the first guy there grimaced at me. "sorry," he said. "there's a 30-dollar buy-in fee." i thought he was joking. wait. for what? the group doesn't offer anything except friendship and people with whom to walk around the city.

he didn't know the answer. just shrugged at me. "you know," he said. "these days, everything costs money."

[blog-for-communications]

Volker Lannert - Universität Bonn Krafttraining aktiviert die zelluläre Müllabfuhr, was unverzichtbar ist, um die Muskulatur langfristig zu erhalten. Das hat ein Forschungsteam um die Universität Bonn gezeigt.

Krafttraining aktiviert zelluläre Müllentsorgung

Bonn, 23.08.2024. In unserem Körper ist die Entsorgung beschädigter Zellbestandteile unerlässlich für die Aufrechterhaltung von Geweben und Organen. Ein internationales Forschungsteam unter der Federführung der Universität Bonn hat nun wesentliche Einblicke in die Regulation eines beteiligten Entsorgungssystems erzielt. Demnach wird dieses durch Krafttraining aktiviert. Die Befunde könnten die Grundlage für neue Therapien gegen Herzversagen und Nervenerkrankungen bilden und auch zum Gelingen bemannter Weltraummissionen beitragen. Die Ergebnisse werden in der aktuellen Ausgabe des Fachmagazins "Current Biology" vorgestellt.

Muskeln und Nerven sind langlebige Hochleistungsorgane, deren zelluläre Bestandteile einem ständigen Verschleiß unterliegen. Bei der Entsorgung beschädigter Bestandteile spielt das Protein BAG3 eine entscheidende Rolle. Es erkennt beschädigte Komponenten und sorgt dafür, dass diese von zellulären Membranen umschlossen werden: Ein sogenanntes Autophagosom entsteht. In diesem „Müllbeutel“ wird der zelluläre Abfall gesammelt und schließlich für ein Recycling zerkleinert. Das Forschungsteam um Prof. Dr. Jörg Höhfeld vom Institut für Zellbiologie der Universität Bonn hat nun gezeigt, dass BAG3 in der Muskulatur durch Krafttraining aktiviert wird. Für die zelluläre Müllabfuhr ist dies wichtig, denn: Erst aktiviertes BAG3 bindet beschädigte Zellbestandteile effizient und treibt die Membranumhüllung voran. Ein aktives Entsorgungssystem wiederum ist unverzichtbar, um die Muskulatur langfristig zu erhalten. „Eine Beeinträchtigung des BAG3-Systems führt in der Tat zu rasch-fortschreitenden Muskelschwächen bei Kindern und zum Herzversagen, eine der häufigsten Todesursachen in westlichen Industrienationen“, erklärt Prof. Höhfeld.

Wichtige Erkenntnisse für Training und Rehabilitation

Sportphysiologen der Deutschen Sporthochschule Köln und der Universität Hildesheim waren maßgeblich an der Studie beteiligt. Der Hildesheimer Professor Sebastian Gehlert betont die Bedeutung der Befunde: "Wir wissen nun, welche Trainingsintensität für eine Aktivierung des BAG3-Systems nötig ist. Das hilft uns, Trainingsprogramme für Spitzensportler zu optimieren und den Muskelaufbau bei Patienten im Zuge der Rehabilitation zu verbessern." Gehlert nutzt diese Erkenntnisse auch bei der Betreuung von Mitgliedern des deutschen Olympiateams.

Nicht nur in Muskeln notwendig

Aber das BAG3-System ist nicht nur in der Muskulatur aktiv. Mutationen in BAG3 können auch zu einer Nervenerkrankung führen, die nach ihren Entdeckern als Charcot-Marie-Tooth-Syndrom bezeichnet wird. Dabei kommt es zu einem Absterben von Nervenfasern in Armen und Beinen. Betroffene können in der Folge Hände und Füße nicht mehr bewegen. Anhand von Zellen, die von Erkrankten stammen, zeigt das Forschungsteam nun, dass es bei bestimmten Formen des Syndroms zu einer fehlerhaften Regulation des BAG3-Entsorgungssystems kommt. Die Befunde belegen somit die weitreichende Bedeutung des Systems für die Gewebeerhaltung.

Unerwartete Regulation weist Weg für Therapien

Eine Überraschung erlebten die Forschenden, als sie die Aktvierung von BAG3 genauer untersuchten. „Viele Proteine werden in der Zelle durch die Anheftung von Phosphatgruppen, die sogenannte Phosphorylierung, aktiviert. Bei BAG3 ist der Vorgang jedoch umgekehrt“, so Jörg Höhfeld, der auch Mitglied im Transdisziplinären Forschungsbereich (TRA) „Life and Health“ der Universität Bonn ist. „In der ruhenden Muskulatur ist BAG3 phosphoryliert und die Phosphatgruppen werden bei der Aktivierung entfernt.“ Damit rücken die Phosphatasen – Enzyme, die die Phosphatgruppen entfernen – in den Mittelpunkt des Interesses. Bei der Identifizierung der Phosphatasen, die BAG3 aktivieren, kooperiert Höhfeld mit der Chemikerin und Zellbiologin Prof. Maja Köhn von der Universität Freiburg. "Die Identifizierung der beteiligten Phosphatasen ist ein wichtiger Schritt", erläutert Köhn. "Es erlaubt uns dann Wirkstoffe zu entwickeln, die auf die Aktivierung von BAG3 im Körper Einfluss nehmen könnten." Damit böten sich gegebenenfalls neue Möglichkeiten zur Behandlung von Muskelschwächen, Herzversagen und Nervenerkrankungen.

Auch für die Raumfahrt bedeutsam

Die Deutsche Forschungsgemeinschaft unterstützt die Arbeiten am BAG3-System im Rahmen einer Forschungsgruppe unter der Leitung von Prof. Höhfeld. Eine Förderung erhält Höhfeld aber auch von der Raumfahrtagentur im Deutschen Zentrum für Luft- und Raumfahrt: "BAG3 wird unter mechanischer Kraft aktiviert. Aber was passiert, wenn die mechanische Stimulierung ausbleibt? Zum Beispiel bei Astronautinnen und Astronauten unter Schwerelosigkeit oder bei immobilisierten und beatmeten Intensivpatientinnen und -patienten?“ erklärt Höhfeld. Die ausbleibende mechanische Stimulierung führt in diesen Fällen zu einem schnellen Verlust der Muskulatur. Höhfeld geht davon aus, dass die fehlende Aktivierung von BAG3 dabei den Muskelverlust vorantreibt. Auch in diesen Fällen könnten Medikamente hilfreich sei, um BAG3 zu aktivieren. Um dies zu klären, bereitet Höhfelds Team unter anderem Experimente an Bord der internationalen Raumstation ISS vor. Die Forschungen zu BAG3 könnten von daher eines Tages dazu beitragen, den Mars zu erreichen.

Förderung und beteiligte Institutionen

Neben der Universität Bonn sind die Universität Freiburg, die Deutsche Sporthochschule, das Forschungszentrum Jülich, die Universität Antwerpen sowie die Universität Hildesheim an der Studie beteiligt. Sie wurde gefördert von der Deutschen Forschungsgemeinschaft und der Raumfahrtagentur im Deutschen Zentrum für Luft- und Raumfahrt.

Originalpublikation:

Ottensmeyer, et al.: Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic. „Current Biology“, DOI: 10.1016/j.cub.2024.07.088; https://doi.org/10.1016/j.cub.2024.07.088

Beitrag zum Blog

Bewegung ist Ausdruck nonverbaler Kommunikation. Technologische Entwicklung und Fortschritt begünstigen das Menschen sich zukünftig weniger Bewegen. Es benötigt daher den freien Wunsch, Willen und Antrieb von Menschen sich bewegen zu wollen. Motivation dafür zu finden. Raus aus der Unterdrückung, rein in ein Selbstbestimmtes Leben gehört zu den Themegebieten des Blogs. Sport, Mode, Smarte Textilien und damit auch Künstliche Intelligenz, in Auswirkung für das Individuum und seiner Teilhabe an der Bildung zur Gesellschaft, sowie als Ausdrucksmittel tiefliegender Kommunikation (Interozeption - Körpersignale aus dem Inneren.)

[normal-thoughts-official]

donated 50 reais to a palestinian GFM today

it amounted to 8 dollars

several days' worth of expenses for me became a single digit donation for them. barely enough for a blanket. just like that

it really sucks to know that my money is inherently less helpful no matter how much it'd pay for me, and there's nothing i can do

[hellsitegenetics]

Which carbon Is your favorite in Thymine specifically?