#KCNR

[ctgreys]

Mca64 launcher 2.0

nnounced this week tht they will not proceed with their plnned record opertis merger. Pge 42 Newsstnd Price $3 50 RADIO & RECORDS Polytrm, Wrners Drop Merger Plns PolyGrm nd Wrner Bros. Pge 4 SUMMER COUNTRY RATINGS SCOREBOARD L Helt checks out Country's rtings performnce in the summer books, mrket -by -mrket. Pge 23 FCC FINES 3 STATIONS The Commissi dished out $40,500 worth of fines to 3 sttis this week, including three $0,000 levies. Pge 2 HOLIDAYS: SALES BONANZA Dwight Cse emphsizes the need to pln hed for the extr benefits holidys cn bring your stti. VP t Msl Chet Trt VP t Blir Rdio Stn Snyder VP t Mnhttn Thoms Lnd WTIX PD Scott McCloud PD t KCNR Steve Grmzy PD for WYMJ Pge 3, 28, 34 PROMOTING NETWORK PROGRAMMING Reed Bunzel lerns how networks nd progrm suppliers re working with sttis to promote their specil progrmming nd dd tht extr edge of ppel. Pge 0 PEOPLE IN THE NEWS THIS WEEK Steve Downes GM t WISN & WBTT Kevin Sutter Chryslis Nt'l LP Promoti Director Susn Bice VP At Aries Phil Roberts Sr. Pge 35, 44 RATINGS DIARIES AUSTRALIAN STYLE Jhn Hiber exmines the McNir Anders rdio listening diry, which bosts n 80% usble return rte from Austrlin prticipnts (double wht Arbitr receives here). Menwhile, WSFM/Hrrisburg sets up comprehensive promoti to help reunite missing kids with their prents. uthorities gng up to defuse the dngerous situti. Pge 36 RADIO'S POSITIVE SOCIAL ACTIVISM Following numerous incidents of gng -relted shootings, KDAY nd L.A. 1 ISSUE NUMBER 559 THE INDUSTRY'S WEEKLY NEWSPAPER NOVEMBER 9, 984 I N S I D E: EXECS CITE AOR MONEY POWER AOR is in gret finncil shpe, ccording to top executives from Tft, Infinity, Shmrock, nd other successful opertis.

[animalmother16]

I’ll be on KCNR 1240 AM/95.5 FM at 6:15 Pacific/9:15 Eastern Interviewed by Radio Wasteland.

[we-burn-so-bright]

dry throat dry eyes

[webercreative]

Redding Trail Alliance Executive Director Nathan Knudsen talks about bringing together government agencies, private resources and outdoors enthusiasts to string together, renew and build anew trails that mean so much to the lifestyle and tourism economy of the region.

Click HERE or click the image below to hear the interview on Scorecard Scribblings, my YouTube channel, which first aired Wednesday night, January 8,  2019 with the on KCNR 1460 in Shasta County, California. You can also learn more at reddingtrailalliance.org. He also talks about why we won’t be hiking the falls trails at Whiskeytown anytime soon (so quit blaming the folks at Whiskeytown National Recreation Area!)

Here are some pics from a couple of work days in 2019 that I took part in – I look forward to volunteering again in 2020.

An alliance to heal and build trails in Northern California: interview with Nathan Knudsen Redding Trail Alliance Executive Director Nathan Knudsen talks about bringing together government agencies, private resources and outdoors enthusiasts to string together, renew and build anew trails that mean so much to the lifestyle and tourism economy of the region.

[cancersfakianakis1]

Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma

Abstract

Catechol-O-methyltransferase (COMT) is an enzyme that inactivates dopamine and other catecholamines by O-methylation. Tolcapone, a drug commonly used in the treatment of Parkinson's disease, is a potent inhibitor of COMT and previous studies indicate that Tolcapone increases the bioavailability of dopamine in cells. In this study, we demonstrate that Tolcapone kills neuroblastoma (NB) cells in preclinical models by inhibition of COMT. Treating four established NB cells lines (SMS-KCNR, SH-SY5Y, BE(2)-C, CHLA-90) and two primary NB cell lines with Tolcapone for 48 h decreased cell viability in a dose-dependent manner, with IncuCyte imaging and Western blotting indicating that cell death was due to caspase-3-mediated apoptosis. Tolcapone also increased ROS while simultaneously decreasing ATP-per-cell in NB cells. Additionally, COMT was inhibited by siRNA in NB cells and showed similar increases in apoptotic markers compared to Tolcapone. In vivo xenograft models displayed inhibition of tumor growth and a significant decrease in time-to-event in mice treated with Tolcapone compared to untreated mice. These results indicate that Tolcapone is cytotoxic to neuroblastoma cells and invite further studies into Tolcapone as a promising novel therapy for the treatment of neuroblastoma.

This manuscript reports a novel mechanism for targeting neuroblastoma through inhibition of catechol-O-methyltransferase with Tolcapone. This results in neuroblastoma cell death, increased intracellular reactive oxygen species levels, decreased ATP levels, and tumor inhibition in xenografts. This treatment provides promising preclinical results, which may be a potential novel treatment for neuroblastoma and is being tested in a Phase I study currently.

http://ift.tt/2p2glZj

[webercreative]

2019 Season In Review: Hot Streaks and Strong Starters

2019 Season In Review: Hot Streaks and Strong Starters

This article, including photos not seen here, originally appeared on the website ReddingColt45s.com here.  A recap of the season with manager Berek Fasking will air on KCNR 1460 AM and 96.5 FM in Shasta County, Wednesday, August 14, 2019 on Brent Weber’s weekly radio show Scorecard Scribblings. An archive of the interview can be heard after that date on www.kcnr1460.com .

The Redding Colt 45s…

[animalmother16]

RADIO INTERVIEW

MARK SLADE@MARKSLADE33·39sI will be interviewed on @RadioWasteLand6  with my Friends Cara and Chauncey, talking about #witchforhire Mon. at 6pm pacific/9pm Eastern, on KCNR AM 1460 Listen here (link: https://www.kcnr1460.com/live-2/) kcnr1460.com/live-2/   or tune in on the radio if yer in Cali.  @ScatterOfAshes @camlette  @writerrausch1

[webercreative]

Colt 45s pre-game radio interviews available to watch

Colt 45s pre-game radio interviews available to watch

Now that yours truly is delivering the radio play-by-play of Redding Colt 45s Summer Collegiate Baseball action, I wanted to make available the pre-game interviews with the players to enhance the efforts on KCNR Radio and with my new talk show, Scorecard Scribblings, airing Wednesday nights at 6:00 p.m. on KCNR in Redding. 

To begin with, I’ve posted interviews with pitcher Eamon Velarde and Andy…