#Ischemic stroke

[reasonsforhope]

A large trial investigating the effectiveness of a celery-seed-derived neuroprotectant drug for use in ischemic stroke cases has shown significant promise.

Patients given the medicine called butylphthalide had a 70% better chance of improved neurological and general living outcomes 90 days post-stroke, a finding generated from a little over 1,000 cases.

Butylphthalide is already approved for use in treating strokes in China. Currently though, the FDA has not approved it for any use.

How butylphthalide works isn’t clear, with animal studies suggesting various possible mechanisms. It may help protect brain tissue from damage when the supply of oxygenated blood is cut off and it works alongside existing clot-busting drugs or procedures to remove blood clots in ischemic stroke conditions.

The trial consisted of 1,216 patients who were admitted for stroke in China where the drug is approved for use, and given it alongside a tissue plasminogen activator (tPA) and/or a mechanical clot removal procedure—two primary means of dealing with ischemic, or clot strokes.

Every year, more than 795,000 people in the United States have a stroke, with 87% of these being ischemic ones. The burden of these events is large, and they are a leading cause of disability in the elderly.

“This is the first trial to show the benefit of using a medication that protects the brain from damage caused by a lack of oxygen to brain tissue...” said Baixue Jia, M.D., co-author of the study...

The results will soon be presented to the International Stroke Conference this week in Dallas, Texas.”

-via Good News Netwwork, 2/6/23

[cripvideoproductions]

Talk to teaching students about stroke in adults and toddlers

On November 21 I spoke to another  class of Carol Carielli’s students learning to be teachers who had seen “A Stroke Of Endurance”. One student asked if the real professor who “A Stroke Of Endurance” is based on had his stroke in class, and I told them he had the stroke on campus but not during our class. I explained to the student the character in the film and the real professor did have side effects of the stroke that made him dizzy which led to a discussion of other different types of strokes, emergency treatments to stop a stroke, and individuals who had mini strokes and concussions which led to questions about institutional developmental delay, early intervention, Cerebral Palsy and my science essays https://medium.com/@dylanrothbein/how-does-mammal-fetal-development-relate-to-developmental-disability-guest-post-by-margot-8d52475fdaec  on Cerebral Palsy like The Moro Reflex https://medium.com/@dylanrothbein/the-moro-reflex-guest-post-by-margot-3d9ccc4758b2  and how the Moro Reflex and gag reflex effect children with Cerebral Palsy and Autism and how some children have both Cerebral Palsy and Autism at the same time. We discussed how teachers must also accommodate parents who have disabilities who have to meet with teachers and access the school buildings. 

This post is posted with permission of Professor Carol Carielli.  

[mukathospital]

Explore advanced stroke treatment at Mukat Hospital, Chandigarh. Our expert team offers comprehensive care, from emergency response to rehabilitation, ensuring the best possible outcomes for stroke patients.

[ricisidro]

PSA 2023 top 6 causes of deaths in the Philippines:

1. Ischemic heart diseases 122,027 (18.8%)

2. Neoplasms or Cancer 69,449 (10.7%)

3. Cerebrovascular 65,224 (10.1%)

4. Diabetes 41,056 (6.2%)

5. Pneumonia 40,082 (6.2%)

6. Hypertension 35,820 (5.5%)

#StayHealthy

https://psa.gov.ph/content/2023-causes-death-philippines-provisional-31-may-2024

[trendykun]

Recognize the Signs: How to Act FAST to Spot a Stroke and Save Lives

Introduction to Stroke Awareness

Stroke is a medical emergency that occurs when there is an interruption of blood flow to the brain, causing brain cells to die. Recognizing the signs of stroke and taking immediate action can save lives and improve recovery outcomes. The importance of stroke awareness cannot be overstated, as timely intervention can mean the difference between life and death, or between full recovery and permanent disability. Read more....

[runawaywidow]

18 Surprising Stroke Facts that I Didn't Know, Until Now

The lullaby music is playing again. So sweet. “Are they trying to make the patients fall asleep?” I smiled at the nurse as she entered the room. “No, that means a baby has just been born,” she replied as she turned off Pete’s call button. We returned to Sarasota Memorial Hospital exactly 5 days after being discharged from my husband’s neck surgery for a cervical spinal fusion. He had been…

[vascular-surgeon-azeemagha]

Best Vascular Surgeon in Islamabad

[dixvlogslive]

Early Signs of Ischemic Stroke -2024

Ischemic stroke is also called brain ischemia or cerebral ischemia. It is one of three forms of stroke (brain ischemia, hemorrhagic stroke, and transient ischemic attack (TIA)). Read more

[dangerdust2]

Is radon linked to health condition other than lung cancer?

Radon is a known mutagen, meaning it can cause genetic mutations, it is also a growing concern because this gas makes its way into homes, and exposure is increasing as modern construction practices make homes more airtight.

We wanted to determine if exposures to high levels of radon are linked to this condition called CHIP, caused by genetic mutations in hematopoietic stem cells.

The condition, called clonal hematopoiesis of indeterminate potential (CHIP), develops when some hematopoietic stem cells, the building blocks for all blood cells, undergo genetic mutations as a person ages.

Cells with such mutations replicate more quickly than cells without them.

Previous research has shown people with CHIP may have a higher risk of blood cancers like leukemia and cardiovascular disease including stroke.

Researchers found participants with ischemic stroke living in areas with the highest concentrations of radon had a 46% increased risk of CHIP, while those living in areas with medium concentrations had a 39% increased risk compared to those living in areas with the lowest concentrations of radon.

Risk was not increased in participants without stroke.

[omg-erika]

When the Stroke Hits You

by Dr.Harald Wiesendanger– Klartext What the mainstream media is hiding Suddenly severely disabled: A stroke can have dire consequences that are often irreversible. In the worst case, it kills. Preventing it is one of the best reasons for a healthy lifestyle, as the AUSWEGE Foundation recommends to everyone. Does a Covid-19 “vaccination” increase the risk? You’ve just filled the shopping cart…

[ctbraininjurysupportservice-blog]

"Know Your Strokes: Understanding the Different Types of Stroke"

#stroke , ischemic stroke, hemorrhagic stroke, transient ischemic attack, #TIA, medical condition, blood flow, brain cells, blood clot, thrombotic stroke, embolic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, high blood pressure, #smoking, high cholesterol, diabetes, #symptoms, treatment options, #rehabilitation life-threatening, prompt medical attention, #awareness#Connecticut#community#braininjuryawarenessy#strokeawareness#caregiver

ABI RESOURCES Advocacy, Community Care and Supported Living

[joseywritesng]

Fetterman's recovery marks way back from stroke

Fetterman’s recovery marks way back from stroke

October 21, 2022 – John Fetterman, Democratic nominee for the Pennsylvania Senate, recovers well from a heart attack he had in late spring, according to a medical report from his doctor. In his evaluation of Fetterman, Clifford Chen, MD, concluded that “he has no work restrictions and can work full duty in public office.” Fetterman is currently Lieutenant Governor. But Chen also noted that the…

[ricisidro]

#Heartdisease is the main cause of death in the #Philippines from January to September 2023, according to Philippine Statistics Authority. (PSA). There was a total of 85,192 cases of #ischemic heart disease or 19% of total deaths within the given period.

https://philstarlife.com/news-and-views/636317-heart-attack-alone-explainer

[coochiequeens]

This article is from last year but since I posted about detransitioners earlier this week I think this is relevant

Testosterone Therapy in a Transgender Male Patient as a cause of Acute Ischemic Stroke (P2-5.011)

Christina Tan, Lauren Kim Sing, Ron Danziger, Alex Aw, Chae Kim, Stephen Avila, Vilakshan Alambyan, Angud Mehdi, Michael Gezalian, Maranatha Ayodele, and Shahed ToossiAuthors Info & Affiliations

April 25, 2023 issue

Objective:

To share an intriguing case of a young transgender male patient receiving testosterone therapy who developed locked-in syndrome due to an acute ischemic stroke and to highlight potential risk factors for stroke in the LGBTQI+ community

Background:

There are many studies identifying risk factors for stroke in racially and ethnically diverse populations. However, there is little existing data for stroke risk factors in the LGBTQI+ community. Prior research has shown testosterone therapy in cis-gender men with initially low levels of testosterone increases the risk of stroke, especially in the first 2 years of use1. While testosterone therapy has been shown to increase the risk of venous thrombosis, its role in arterial thrombosis is unclear2. A proposed mechanism for thrombosis with testosterone replacement includes erythrocytosis, but the potential contribution of an independent pro-coagulant effect is yet to be determined3.

Design/Methods:

Literature review and case report.

Results:

An otherwise healthy 23-year-old transgender male on one year of testosterone therapy presented in an obtunded state. Examination revealed complete quadriplegia with sparing of vertical eye movements, consistent with locked-in syndrome. Imaging revealed complete occlusion of the basilar artery with distal reconstitution at the superior cerebellar arteries, and a large bilateral ischemic infarct of the pons. Computed tomography angiography did not demonstrate other large vessel disease or structural vascular abnormalities. Unfortunately, the patient was out of the time window for any acute stroke interventions. A hypercoagulable workup was performed but results were unrevealing and hematocrit was normal. Further investigation with transthoracic echocardiogram, transesophageal echocardiogram, and telemetry were negative for thrombus, patent foramen ovale, and atrial fibrillation.

Conclusions:

Acute ischemic stroke may be an under recognized complication of testosterone therapy in transgender males independent of degree of erythrocytosis. Further research is needed to establish a safety profile of testosterone therapy in this understudied population.

Disclosure: Dr. Tan has nothing to disclose. Mrs. Kim Sing has nothing to disclose. Dr. Danziger has nothing to disclose. Mr. AW has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Avila has nothing to disclose. Dr. Alambyan has stock in Teleflex. Dr. Alambyan has stock in Natera. Dr. Alambyan has stock in Labcorp. Dr. Alambyan has stock in Veracyte. Dr. Alambyan has stock in Vicarious Surgical. Dr. Alambyan has stock in Unity Biotechnology. Dr. Alambyan has stock in Scynexis. Dr. Alambyan has stock in Stryker. Dr. Alambyan has stock in Eli Lilly. Dr. Alambyan has stock in DaVita. Dr. Alambyan has stock in Invitae. Dr. Alambyan has stock in Pfizer. Dr. Alambyan has stock in Bristol-Myers Squibb. Dr. Alambyan has stock in Johnson and Johnson. Dr. Alambyan has stock in Merck. Dr. Alambyan has stock in Medtronic. Dr. Alambyan has stock in AbbVie. The institution of Dr. Alambyan has received research support from Albert Einstein Healthcare Network. Dr. Mehdi has nothing to disclose. Dr. Gezalian has nothing to disclose. Dr. Ayodele has nothing to disclose. Dr. Toossi has nothing to disclose.