maybe this is a little vague, but how long would it take for a coma patient to die after their life support is withdrawn?
Very interesting question. It depends on what life support measures are being implemented, and how dependent on them the person is.
Life support is a range of different machines and therapies designed to keep a person alive. This ranges from something called ECMO, which effectively takes over for the heart and lungs for temporary periods, to simply a tube that goes from the nose to the stomach to deliver food and water to a person who cannot eat or drink.
As stated above, the most intensive life support is ECMO, which is essentially a machine that takes over the functions of the heart and lungs temporarily- oxygenating blood outside the body and circulating it. This is usually used in open heart surgery, though it can be used in some ICUs for longer periods of time. Assuming the person is entirely dependent on ECMO (as in, they do not have heart or lung function on their own), they would begin to die within minutes of ECMO being withdrawn.
Next down might be something like a ventilator. Ventilators have different modes that allow a person who has some respiratory function on their own to continue exercising it while being supported mechanically.
For example, someone may be on a ventilator only to provide extra pressure to overcome the resistance from a tube that goes from their mouth to their lungs to hold open their airway, and sometimes it adds pressure to make it easier for the person to pull in breaths. This person can probably breathe on their own for an indeterminate amount of time and would not necessarily die if the ventilator was withdrawn, though they may have trouble keeping their airway open or they may tire out easily trying to breathe.
Another vent setting involves the patient breathing as much as they can, and the ventilator serving as a backup. If the person doesn't take a breath in a set number of seconds, the ventilator gives them one. This person may survive for a while afterwards, but would likely eventually die due to high levels of carbon dioxide in their blood. It might be any time between an hour or less to several days before the person's death.
The highest setting on most vents still allows the patient to initiate breaths, but every breath they take is assisted to ensure it is a complete breath, and the machine also delivers a set number of breaths every minute. Someone who is dependent on this mode may pass within minutes of being taken off the vent and likely wouldn't live more than an hour or so, dying from lack of oxygen or buildup of carbon dioxide.
Another life support device is a cooling blanket. When certain parts of the brain are damaged (such as the parts that are damaged after a long period without oxygen), the person cannot control their own temperature, and they tend to get extremely overheated by their own metabolism. Temps can get into the 110's *F, which kills pretty quickly. Fever-reducing drugs are not effective. This would also be someone who could last anywhere from an hour or so to a couple of days, though their brain would quickly become more and more damaged during this time.
The least intensive form of life support would be the provision of food or water through an NG tube- a tube that goes from the nose to the stomach and allows medications and tube feed (water and basic nutrition) to be delivered to the stomach. If this is withdrawn and IV fluids are not provided, the person may live a week or more before dying of dehydration. If they are, for some reason, given IV fluids, they may live months.
Note that a person may be on a combination of modalities (like it would be weird for someone to be on a ventilator without an NG tube).
-Ross ( @macgyvermedical)
64 notes
·
View notes
Biological Disaster
Biological disaster
--------------------
( BDLS & ADLS)
Factors that compose the "chain of infection"
1. Infectious agent
- the greater virulence,invassiveness & pathogenicity --> the greater possibility organism will cause infection
2. Reservoirs
- the infectious agent normally lives & multiply , can reproduce itself & transmitted to susceptible host
3. Portal of exit
- biological agent leave the reservoir
4. Mode of transmission
- mechanism which infectious agent is spread
- can be airborne,droplet , direct & indirect physical contact, fecal oral transmission , vector mediated transmission
5. Portal of entry
- infectious agent enter host through skin,mucous membrane, lung. GIT, genito urinary , placenta , invasive procedure
6. Susceptible host
- influence by factors:
1, hod defense characteristic
2. Medical condition immunocompramised
3. Malnutrition
4. Pregnancy
5. Age
6. Increase exposure risk
7. Behavior factors
Biological disaster
---------------------
Epidemic:
- illness that occur in higher number that expected within a country & region.
Pandemic:
- worldwide epidermic disease
- 3 condition:
1. New disease emerges to a population has little or no immunity.
2. Disease is infectious for humans
3. Disease spreads easily among humans
Bioterrorism
Criminal act that causes illness, both law enforcement & public health authorities have responsibility to responds .
Intention use of biological agent to harm human or living organism.
- inexpensive
- easy to produce
- easy to disguised
- difficult to defend
Potential BT threats
----------------------
Category A: high priority agents
- easily disseminated
- high mortality
- causes public panic
- require public health for special action
Eg antarax,botulism,plaque,small pox & tularemia, viral haemorrhagic fevers
Category B: second priority agents
- moderate easy to disseminate
- moderate morbidity & low mortality
- require enhancement of CDC
Eg brucelosis
Clostridium perfrongens
E. coli
Meliodosis
Q fever
Viral encephalitis
Category C: third priority
- easily available
- easily produced or disseminated
- potential for high morbidity & mortality
Eg Nipah virus, SARS
Situational awareness & detection
----------------------------------------
- high index of suspicious
- usually multiple report
- simultaneously outbreak of different diseases in same locale
- large number of casualties in hours to days
Clue for bioterrorism attack
--------------------------------
1. Increase in unexplained deaths
2. Unusual age distribution of patient
- severe illness 20-50 years
3. Unusual seasonality
4. Unusual manusfestation of disease or occurrence of animal die off
- antarax: inhalation
Clinical decision making
----------------------------
Characteristic clinical symptoms of selected potential BT agents
1. CXR: Widening mediastinum
- anthrax
2. Symmetrical flaccid paralysis
- botulism
3. Hemoptypsis
- pneumonic plaque
4. Pox like rash
- small pox
5. Diarrhoea
- cholera
- shigelosis
Transmission based infection control
-------------------------------------------
(I) Droplet precaution
------------------------
- transmitted by large particle droplet >5um
- through cough, sneeze, talk or resp care procedure.
Rx
1. 3 feet away
2, surgical mask or respiratory care procedure
(II) contact precaution
--------------------------
- transmitted by direct contact with patient or indirect contact with potentially contaminated surfaces
Rx
Wear gloves
Gown
Remove gown before enter
Wash hand
(iIi) Airborne precaution
----------------------------
- limit transmission airborne droplet <5um of evaporated droplet containing microorganism that remain suspended in air for long time or dust particles.
Rx
N95
Powered air purifying respirators m
Negative pressure room with minimum six air exchanges per hour
- exhaust direct outside or high efficient particulate air filtration
If source unknown:
Contact precaution & N95 or better respiratory
Triage
--------
Goal
- prevent 2' transmission through implementation non medical strategy
Triage model
SEiRV
- Susceptible: person not yet exposed but susceptible
- exposed: susceptible & have in contact with infected person, they maybe infected but not contagious
- infectious: symptomatic & contagious
- removed: no longer transmit disease as they survived or died
- vaccinated : prophylactic medication intervention to protect them from infection
Rx
Self protective measures
Designated evacuation areas
ABCs
Clinical assessment & diagnosis
------------------------------------
Fbc
ABG
Nasal swab for culture & pcr
Blood for bacterial culture & pcr
Serum for serological studies
Sputum for c&s
Blood & urine Tox
Throat swab for viral culture, Pcr & enzyme linked immunosorbent assay
Environment samples
Theurapeutic intervention
Established diagnosis
Prompt therapy
Eg antarax & plaque / treatment within 24H
( longer - grim prognosis)
Biological agent - specific issues
( I) Anthrax
-------------
Causative agent: bacillus anthracis
Site of infection :
1. Cutaneous
2. Inhalation
3. GIT
Incubation period: 1-7 days ( as long as 12/7)
Presentation
Small itchy papule or vesicles
2nd day : ulcer
Usually on exposed area of body
Non render swelling around ulcer
Small vesicles may surround ulcer
Then black scab or ESCAR x 2/52
80-90% resolves
LN +
Fever +
Inhalation antarax
Incubation: 2-43/7
Presentation
*** classical : fever & respiratory distress + shock + widening mediastinum
Flu like illness
- fever
- fatique
- cough
- sob
- headache
- anorexia
Then
Sudden increase in fever
Respiratory distress
Diaphoresis
Shock
CXR
Widening mediastinum
Inflitrates
Pleural effusion
GI anatarx
Ingestion contaminated meat
Nausea
Vomiting
Bloody diarrhoea
Ix
Blood culture
- gram positive bacilli
Gram stain
Sputum
CXR: widening mediastinum
Rx
IV ciprofloxacin 400mg bd
Or
IV doxycycline 100mg bd
Standard barrier precaution only
No need airborne precaution
Mneumonic: AB CD
( Anthrax bacillus cipro doxy )
Botulism
Causative: toxin by C.botulinum
One of the most poisonous substance known
Clinical features
Onset: 12-36Hv
1. Bulbar palsy
2. Blepharoptosis
3. Bluring vision
4. Dry mouth
5. Difficulty speaking
6. Trouble swallowing
( descending pattern paralysis)
" descending type of paralysis"
No fever
Not confused
Not obtunded
Rapid onset
Severity depends on amount toxin absorbed
7. Descending symmetrical skeletal muscle paralysis
8. Respiratory muscle paralysis
Diagnosis
" clinical presentation"
Confirmatory : blood toxin assay
Treatment
-----------
Supportive - intensive care + close monitoring respiratory failure & feeding
May take 1-3/12 for the toxin to resolved. Hence; need ventilatiry support if intubated.
Antitoxin
- only stop the progression paralysis but will not reverse the existing paralysis.
No prophylaxis
Standard precaution for infectious control.
- no person to person transmission
Pneumonia plaque
--------------------
Causative agent: Y. pestis
Highly fatal
Person to person
Via flea vector
Route; aerosolization ( common)
Clinical features
------------------
Incubation period: 1-6/7
Classical: fever + chills + intense swelling LN in one area.
But if terrorist attack with spray:
Fever , cough ---> rapid pneumonia
1. Abrupt onset high fever
2. Chills
3. Malaise
4. SOB
5. Cough with bloody sputum
6. Sepsis
7. Nausea
8. Vomiting
9. Diarrhoea
10. Severe rapidly progressive pneumonia
Diagnosis
CXR: pathchy infiltrates
Culture blood & sputum
Gram stain : safety pun bipolar staining
Rx
IM Streptomycin
iM /IV gentamicin
Pregnant: gentamicin preferred
Prophylaxis
Doxycycline
Or
Ciprofloxacin
Infectious control:
Droplet precaution for 48H
- must be 3 feet away
Mneumonic:
PSG Department
Plaque streptomycin gentamicin droplet precaution
SARS
-------
Causative agent
-------------------
SARS associated coronavirus
Clinical features
-----------------
IP: 2-7 days
1. Flu like prodromal
2. Fever with chills & rigors
3. Headache
4. Muscle aches
5. May hv diarrhoea
Day 3-7:
Cough
SOB
Diagnosis
Probable SARS:
Severe respiratory illness
Unknown etiology
Epidemiology of exposure
Lab criteria used to confirm
Suspected SARS:
Moderate respiratory illness
Unknown etiology
Epidemiology for exposure
Lab criteria to confirm
Moderate respiratory illness
- temp > 100.4'c
- respiratory findings
1. Cough
2. Sob
3. Hypoxia
Severe respiratory illness
- moderate respiratory illness + one findings as below:
1. X-ray: pneumonia
2. Respiratory distress syndrome
3. Autopsy: pneumonia or RDS w/o cause
Epidemiology
- exposure to SARS in travel within 10/7 to area with current,documented or suspected SARS.
Treatment
No proven Tx
Antibiotic to cover CAP & atypical pathogens
Prophylaxis
No known
Infection control
- standard precaution ( hand wash)
- contact precaution ( gown & gloves)
- airborne precaution ( -ve pressure room & N95)
- eye protection
Smallpox
-----------
Mortality rate
30%
Clinical features
IP: 7-17 days
Prodromal
( more severe than chicken pox)
( look sick before rashes appear)
- lasting 2-3/7
- fever
- myalgia
- prostration
- nausea
- vomiting
- delirium
Rash
( all same stages of maturity)
( more rounded)
( more in face & extremities while chicken pox more in trunk )
( chicken pox less on palm & soles)
( start periphery then go centrally)
" outside to inside"
" all same stage"
- start on face & extremities including palm & soles
Then spread to trunk
( macular --> papular--> vesicles--> pustules )
- form,deep & umbilicated
- rash scan over 1-2/52 resulting in scars
Diagnosis
1. Clinical recognition
2. History
3. Confirmatory test in CDC
Treatment
Vaccination small pox
- very effective if within 3/7 exposure
Supportive care
Daily eye rinsing
Adequate hydration & nutrition
Start penicillase resistant antibiotic if :
1. Secondary infected
2. Bacterial endangers the eyes
3. Eruption very dense & widespread
Specific therapy
No specific therapy
If corneal lesions: topical isoxuridine
Cidofovir
Infection control
------------------
Airborne & contact precaution
Treated in negative pressure room
Tularemia
-------------
Agent
Francisella tularensis
Spread:
Ticks or biting flies
Direct bite by rabbits
Clinical features
------------------
Classical; fever + tender papule --> ulcer with eschar + tender LN
If terrorist by spray; fever + shock + pneumonia
IP: 3-5/7
1. Acute febrile illness with prostration
2. Conjunctivitis or skin ulcer with regional adenopathy
3. X-ray: pneumonia (80%)
Diagnosis
-----------
Blood C&S
Gram -ve coccobacillus
Treatment
------------
IV streptomycin + gentamicin
Alternative:
Doxycycline
Ciprofloxacin
Chromphenicol
Prophylaxis
Doxycycline
Ciprofloxacin
X 14/7
Infection control
------------------
- not spread from person to person
- standard precaution.
- no need any isolation
- notification immediately
Viral haemorrhaguc fever
-----------------------------
Examples
1. Filovirus
Ebola
Marburg
2. Arenavirus
Lassa
Machupo
Transmitted
Infected animal or arthopods
Mortality rate
Ebola: 90%
Clinical features
-------------------
IP: 2-21/7
Presentation:
1. Non specific prodromal
2. Hypotension
3. Relative bradycardia
4. Rapid breathing
5. Conjunctivitis
6. Pharyngitis
7. Generalized bleeding problems
- mucous membrane haemorrhage
- shock
- hematemesis
- hemoptypsis
- hematochezia
2 haemorrhagic symptoms in severely ill patient with t >101F <3/52 with no other alternate diagnosis
Diagnosis
-----------
High index suspicious
Thrombocytopenia
Leukopenia
aST raised
Lab detection of antigen & antibodies
Treatment
------------
Supportive
Ribavirin
Prophylaxis
----------------
None
Isolation
-----------
Contagious after contact blood & bodily fluids
Liquid impervious protective coverings ( leg & shoe coverings) + double gloves
N95 or better
Face shield
Googles
Negative pressure room
Clinical consideration for pediatric casualties
----------------------------------------------------
More vulnerable
- breathes more per min than adults
- skin thinner & larger surface area ratio
- small fluid reserve
- some agents have shorter incubation period in children
- present with different symptoms
- preventive & theurapeutic regime not studiesbin infant & children
0 notes