#HIV research

[fidicushiv]

Call : +917997101303 | Whatsapp : https://wa.me/917997101505 | Website : https://fidicus.com

HIV పుట్టుకకి గే మనుషులే కారణమా? History HIV Virus | HIV AIDS Treatment Medicine | Dr. Bharadwaz

Explore the history of HIV in this informative video, tracing its origins from the early 20th century to its global recognition in the 1980s. Learn about the discovery of the virus, its impact on public health, and how it became a global epidemic. We also delve into major scientific breakthroughs, the development of treatments, and ongoing efforts to combat HIV/AIDS. Gain a deeper understanding of HIV's past and the lessons learned in the fight against this virus.

Dr. Bharadwaz | HIV AIDS | Health & Fitness | Homeopathy, Medicine & Surgery | Clinical Research

#HIVHistory #HIVAIDS #GlobalHealth #VirusEvolution #hivawareness

#DrBharadwaz #Helseform #Fidicus #Clingenious

#ClingeniousHealth #HelseformFitness #FidicusHomeopathy #ClingeniousResearch

#FidicusHIV #HIV #AIDS #HumanImmunodeficiencyViruses #AcquiredImmuneDeficiencySyndrome

#Treatment #Cure #Prevent #Relieve #Medicine #Vaccine

#AlternativeTherapy #AdjuvantTherapy #AlternativeMedicine #AlternativeSystem

Specialty Clinic Fidicus HIV highest success with homeopathy Improve Wellness | Increase Longevity | Addresses Questions

[morningmantra]

Navigating Life with HIV: A Journey of Resilience and Hope

Navigating Life with HIV: A Journey of Resilience and Hope

Understanding HIV and AIDS HIV, or the Human Immunodeficiency Virus, is a virus that attacks the body’s immune system, the body’s defense against infections. Over time, HIV can weaken the immune system to the point where it’s unable to fight off infections and diseases. This weakens the overall health and increases the risk of developing serious infections and illnesses. AIDS, or Acquired…

[reasonsforhope]

"Five people have gone into remission thanks to advancements in medicine — and a sixth patient may also now be free of HIV.

One of the biggest breakthroughs in HIV/AIDS prevention in recent years is the widespread use of PrEP (pre-exposure prophylaxis). 

This drug therapy, approved by the Federal Drug Administration in 2012, has been a key player in preventing HIV transmission through sex or injection drug use. Antiretroviral drugs, such as PrEP, also slow the replication of the virus and prevent it from progressing to AIDS.

Although PrEP has become a more accessible treatment for the virus, scientists have been hurriedly working towards cures for HIV for decades — and we’re finally seeing some results.

In February of this year, scientists in Germany confirmed a fifth-ever patient had been cured of HIV after receiving stem cell transplants that include genetic mutations that carry a resistance to HIV. 

But it looks like a sixth patient may soon be able to join this very exclusive club. 

The man, referred to as the “Geneva patient,” underwent a stem cell transplant after cancer treatment, though these cells did not include the HIV-resistant genetic mutation. 

Still, he went off antiretroviral therapy for HIV in November 2021, and his viral load remains undetectable. 

Instead, doctors are researching whether a drug called ruxolitinib may be partially responsible for his recovery. 

Ruxolitinib decreases inflammation associated with HIV by blocking two proteins, JAK1 and JAK2. This helps kill off “reservoir cells” that lay dormant in the body and have a potential to cause rebounds in patients with HIV.

Experts say the AIDS crisis can end by 2030 across the globe — as long as leaders prioritize this goal. 

A new report from UNAIDS shows a clear, optimistic path to ending the AIDS crisis. (This looks like a 90% reduction in cases by 2030.)

The organization’s report includes data and case studies that show that ending AIDS is a political and financial choice — and that governments that have prioritized a path towards progress are seeing extraordinary results.

By following the data, science, and evidence; tackling inequality; and ensuring sufficient and sustainable funding across communities, the global community could wipe out the AIDS pandemic by the end of the decade.

The report demonstrates that progress has been strongest in the countries and regions that have the most financial investments, like eastern and southern Africa, where new HIV infections have been reduced by 57% since 2010. 

Investments in treatments, education, and access to care have also led to a 58% reduction in new HIV infections among children from 2010 to 2022 — the lowest number since the 1980’s.

Plus, the number of people on antiretroviral treatment around the globe has risen from 7.7 million in 2010 to 29.8 million in 2022.

The moral of the story? This goal can be achieved, if world leaders put their minds — and wallets — to it. 

A region in Australia might be the first place in the world to reach the United Nations targets for ending HIV transmission. 

Researchers believe that the central district of Sydney, Australia is close to becoming the first locality in the world to reach the UN’s target for ending transmission of HIV. 

Specifically, new infections among gay men have fallen by 88% between 2010 and 2022. In fact, there were only 11 new HIV cases recorded in central Sydney last year, and almost all HIV-positive Australians are on antiretroviral drugs. 

... "These numbers show us that virtual elimination of HIV transmissions is possible. Now, we need to look closely at what has worked in Sydney, and adapt it for other cities and regions across Australia.”

Namibia is ahead of schedule in UN targets to end HIV/AIDS. 

Although the virus is still the leading cause of death in Namibia, the country is well on track to hit 95-95-95 UNAIDS targets before its 2030 deadline. 

In Namibia, 92% of people know their HIV status, 99% of people living with HIV are on treatment, and 94% of people living with HIV who are on treatment are virally suppressed.

In addition to these exciting statistics, new infections have plummeted. The estimated rate of new HIV infections in Namibia is five times lower than it was in 2002, according to the Centers for Disease Control & Prevention.

These encouraging numbers are thanks to the investment and strategic response of PEPFAR, but also to the willingness of local governmental agencies and organizations to adhere to the UN’s Fast-Track approach.

Breakthroughs are being made in HIV vaccine therapies.

Long before we were all asking each other “Pfizer or Moderna?” about our COVID-19 vaccines, scientists have been researching the potential of mRNA vaccines in treating some of the world’s deadliest diseases — like HIV.

And with the success of our mainstream mRNA vaccines, an HIV inoculation remains a goal for researchers across the globe.

Last year, the National Institutes of Health launched a clinical trial of three mRNA vaccines for HIV, and similar studies are being conducted in Rwanda and South Africa, as well. 

CAR T-cell clinical trials are underway to potentially cure HIV.

This spring, UC Davis Health researchers have dosed the second participant in their clinical trial, which poses the use of CAR T-cell therapy as a potential cure for HIV.

The study involves taking a participant’s own white blood cells (called T-cells), and modifying them so they can identify and target HIV cells, ultimately controlling the virus without medication. 

The first participant in the study was dosed with anti-HIV T-cells last August, and the trial is the first of its kind to utilize this technology to potentially treat HIV. 

Of course, the trials have a long way to go, and the lab is still preparing to dose a third participant for the study, but CAR T-cell treatments have been successful for lupus and forms of cancer in the past...

“So far, there have been no adverse events observed that were related to the treatment, and the two participants are doing fine.”

Guidance on how to reduce stigma and discrimination due to HIV/AIDS is reaching people around the globe.

While the stigma surrounding HIV and AIDS has significantly decreased — especially towards the LGBTQ+ community — with advancements in treatment and prevention, discrimination is certainly not gone. 

While most people now understand HIV/AIDS better than they did decades ago, those most impacted by the virus (like gay men and low-income women and children) still face ongoing barriers to care and economic security. 

It is vital to maintain awareness and education interventions. 

After all, experts suggest that eliminating discrimination and stigma are key factors in reducing disease.  And not eliminating stigma impedes HIV services, argues UNAIDS, “limiting access to and acceptance of prevention services, engagement in care, and adherence to antiretroviral therapy.” 

Luckily, UNAIDS provides guidance on how to reduce stigma and discrimination in the community, workplace, education, health care, justice, and emergency settings. 

The goal is to, of course, decrease stigma in order to decrease disease, but also to provide folks with the culturally significant support they need to live safe, integrated lives — with or without disease. 

For instance, a 2022 study conducted in Northern Uganda showed that local cultural knowledge passed through Elders was a successful intervention in reducing HIV-related stigma among young people.

“Research in school settings has shown that the use of local cultural stories, songs, myths, riddles, and proverbs increases resilient coping responses among students and strengthens positive and socially accepted morals and values,” the study’s discussion reads. 

So, while an uptick in acceptance gives us hope, it also gives us a directive: Keep telling the accurate, full, and human stories behind HIV/AIDS, and we’ll all be better for it. "

-via GoodGoodGood, August 3, 2023

[kittykatninja321]

what’s crazy is that just a year ago I was using the data on the CDC website to research HIV statistics/history for a college project, and right now someone who got the same assignment I did might be having a much harder time with that project because that information is being censored by the government

[daisiesonafield-blog]

Abstract:

Full article here

[zeddimusprime]

Trans Man Noah Diaz

The first time I saw Rise of the Beasts, I read Noah as a Trans Man, and that headcanon just solidified after my second viewing.

I’ll get the heavy reasons out of the way first, and work down to the most silly ones.

The section that was here before has been removed, because I was overstepping and someone rightly called me out on it. However. I’m not going to lie and pretend I didn’t do what I did. I deleted the comment that called me out because it made me feel bad, I panicked, and deleted it to save my own ego. It was wrong, it was cowardly, it was fucked up, and I shouldn’t have done it.

I truly am sorry, and have spent the last day sitting with myself until I stopped trying to excuse my behavior and just acknowledged what I did. I am not asking for forgiveness, I can only try going forward to be the kind of person deserving of it.

For now, I’m taking a break from this blog, leaving it on a queue, and I won’t be posting here for a while. Even though that isn’t the kind of person I want to be, I need to reckon with the fact that that is the kind of person I am. I’m sorry, once again.

1994 was also the year Don’t Ask, Don’t Tell was put into place, which, for those too young to remember, was basically a policy allowing queer and trans people to serve in the military so long as they remained closeted, and prohibited superiors from forcibly outing them. Given that we’re never actually told in the film why Noah was discharged, it’s not unreasonable to think that it may have been because he got found out as trans.

The part that’s particularly personal for me is his relationship with Kris. I’ve also got a little brother that’s quite a bit younger than me, and I acted as an extra parent to him, practically raised him since we were both latchkey kids, and yeah, there’s no doubt in my mind that I’d face the apocalypse head on if it meant keeping him safe. All that to say, it’s comforting to think that Noah’s identity as a man is inseparable from his identity as a Big Brother, the way it is for me.

Most of my other reasons are less serious:

Noah wears a lot of layers and baggy clothes on his upper half, which yes, was part of 90s fashion, but it’s also how I dressed for most of my life, even before I realized I was trans.

Noah is also non-toxically masculine in a way that’s not unheard of but also not as common for men, especially service members, of that time period. Again, there may very well be a cultural component I’m missing here, let me know if there is, but this is just something I related to as a Guy Who Wasn’t Raised As One.

This last one’s kinda silly, but I’m a Car Guy, and one of the most gender euphoria inducing things I can do is work on my car. There’s few things that make me feel like Man quite like sweat on my brow and grease on my hands and a purring engine from a job well done. So for Noah to not only be a tech wiz but specifically a Mechanic? That was the thing that really sold me on this headcanon. (And that’s not even getting into the very fun implications of Noah being the one to repair Mirage, to get to know him so intimately, literally inside and out. Very nice.)

(I also love the idea that rather than being weirded out or taken aback at first like he is in some fics, Noah would be kinda weirdly affirmed to find out that not only does Mirage have some of roughly the same *equipment* while still being treated as and being a Mech, but his setup is the norm for Cybertronians. I can so picture Noah anxiously telling Mirage about his situation when they finally get together only for Mirage to be like “you mean other human mechs don’t have a 🐈??? Like, most humans only have one or the other?????”)

[woodsfae]

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency. By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus.

[tvnacity]

if I had a nickel for every time someone came to their appointment with an untreated, dangerous, highly contagious disease and lied to us about it, saying they don’t have it, until after we’d done their whole visit and drawn their blood, I’d have two nickels. Which isn’t a lot. But it’s fucking diabolical that it’s happened twice

[reasonsforhope]

"The “Düsseldorf Patient”, a man now aged 53, is just the third person worldwide to have been completely cured of HIV via stem cell transplantation.

As in the case of the other two patients, the so-called “Berlin Patient” and “London Patient,” the transplantation was undertaken to treat an acute blood disease, which had developed in addition to the HIV infection.

The Düsseldorf Patient received a stem cell transplant used to treat leukemia in 2013 and has shown persistent suppression of HIV-1 ever since, including during the last 4 years after the patient stopped taking anti-retroviral medication.

“I still remember very well the sentence from my family doctor: ‘don’t take it so hard,'” the Düsseldorf Patient, who had leukemia as well as HIV-1, said in a statement. “‘We will experience together that HIV can be cured!’ At the time, I dismissed the statement.”

Allogeneic hematopoietic stem cell transplantation (HSCT) is a procedure used to treat certain cancers, such as leukemia, by transferring immature blood cells from a donor to repopulate the bone marrow of the recipient.

Scientists now understand that individuals with two copies of the Δ32 mutation in the gene for the HIV-1 co-receptor CCR5; are resistant to HIV-1 infection. The two previous cases of both the London patient and the Berlin patient involved receiving a stem cell transplant from a donor with these unique mutations.

Björn-Erik Jensen, a specialist in infectious diseases at Düsseldorf University Hospital, lead the treatment and subsequent research, revealed today in a peer-reviewed study in Nature.

The patient was diagnosed as having acute myeloid leukemia and proceeded to undergo transplantation of stem cells from a female donor in 2013, followed by chemotherapy and infusions of donor lymphocytes.

After the transplantation, anti-retroviral therapy was continued, but HIV was undetectable in the patient’s blood cells. Anti-retroviral therapy was suspended in November 2018 with the patient’s informed consent, almost 6 years after the stem cell transplantation, to determine whether the virus persisted in the patient.

“I very much hope that these doctors will now get even more attention for their work,” said the patient. “I have now decided to give up some of my private life to support research fundraising. And of course, it will also stay very important for me to fight the stigmatization of HIV with my story.”

The authors conclude that although HSCT remains a high-risk procedure that is at present an option only for some people living with both HIV-1 and hematological cancers, these results may inform future strategies for achieving long-term remission of HIV-1."

-via Good News Network, 2/20/23

VERIFIED 10 YEARS ON, PROOF THAT HIV IS CURABLE

[evitcani-writes]

“It seems like almost all of those people don’t have HIV,” said Jennifer Kates, HIV policy director at KFF, a health-research nonprofit. “If they did, that would be substandard care at a pretty severe level,” she said.

Ya’ll. United Health just got accused of $17 billion in medicare fraud.

Basically they made up diagnosis which are improbable or impossible, “forgot” to remove ones which had been cured, and overall allegedly stole billions from taxpayers.

The government pays insurers a base rate for each Medicare Advantage member. The insurers are entitled to extra money when their patients are diagnosed with certain conditions that are costly to treat.

… About 18,000 Medicare Advantage recipients had insurer-driven diagnoses of HIV, the virus that causes AIDS, but weren’t receiving treatment for the virus from doctors, between 2018 and 2021, the data showed. Each HIV diagnosis generates about $3,000 a year in added payments to insurers.

… He said internal company data for 2022 showed a treatment rate for patients UnitedHealth diagnosed with HIV of more than triple what the Journal found. He said the pandemic disrupted care, lowering treatment rates during the period analyzed by the Journal, and that the analysis failed to account for patients who started treatments in future years.

The Medicare data, however, show UnitedHealth’s patients with insurer-driven HIV diagnoses were on the antiretrovirals at low rates even before the pandemic, and hardly any started the drugs in the years after UnitedHealth diagnosed them.

Source: https://www.wsj.com/health/healthcare/medicare-health-insurance-diagnosis-payments-b4d99a5d

I bet United Health really wishes it was a different week right now.

UPDATE/EDIT: Article is from July. I didn’t notice myself since it came up in my news feed. Don’t always trust the internet to be time accurate. 😎My guess is it is getting promoted due to current events. However, there are some updates concerning actions taken based on the report which you can look into by checking the authors’ other articles.

[thatstormygeek]

Link for study screening questionnaire here

[flyonthewallmedstudent]

HIV hasn't been cured, but now it's manageable. You can live a long (relatively) normal life with HIV. It's a chronic disease, under the same umbrella as diabetes, COPD etc.

Oncologists are now striving for the same thing.

It has been amazing to see how aids has been controlled, definitely a win for humanity

[positivesinglesmeet]

for std and herpes dating

[biotechnewsalert]

Ex-CytoDyn CEO, Amarex CEO charged for allegedly defrauding investors

In another twist down the CytoDyn rabbit hole, former CEO Nader Pourhassan, Ph.D., and Amarex CEO Kazem Kazempour are both facing multiple charges for their alleged roles in schemes to defraud investors.

The two executives are accused of exaggerating the progress of CytoDyn’s leronlimab, an investigational monoclonal antibody being tested in several indications, according to a Dec. 20 release from the Department of Justice. Pourhassan and Kazempour allegedly deceived investors about the timeline and status of FDA submissions to boost the biotech’s stock price and pull in new investors.

Pourhassan is known for his decade serving as CytoDyn’s president and CEO until being ousted by the board this January. Meanwhile, Kazempour is the co-founder, president and CEO of Amarex Clinical Research, a CRO that managed CytoDyn’s trials and interactions with the FDA. Kazempour was also a member of CytoDyn’s disclosure committee, which reviews and approves the biotech’s filings with the U.S. Securities and Exchange Commission (SEC).

The Dec. 20 indictment alleges that the two made false and misleading representations about CytoDyn’s biologics license application (BLA), which was submitted to the FDA regarding leronlimab as a potential treatment for HIV.

In April 2020, after the two companies failed to meet publicly disclosed timelines for the application, Pourhassan allegedly told Kazempour and Amarex to submit an incomplete BLA so CytoDyn could announce the submission to investors. Pourhassan and Kazempour allegedly knew that the FDA would not evaluate an incomplete application.

According to an SEC release, Kazempour signed off on the incomplete submission and proceeded to sell more than $420,000 of CytoDyn stock.

Within days, the FDA had gotten back to the company about the BLA’s deficiencies, but the former CytoDyn CEO didn’t tell shareholders about this, according to the SEC. The CEO is accused of selling $15.8 million worth of the biotech’s stock based on the false information, raking in a profit of more than $4.7 million.

“The indictment alleges that these defendants conspired to defraud investors in order to line their own pockets,” Erek Barron, U.S. attorney for the District of Maryland, said in a Dec. 20 release. “Investors must be able to rely on the statements of biotech companies about their products. Executives who knowingly mislead investors must be held accountable.”

Pourhassan is also accused of causing CytoDyn to make false and misleading representations about developing leronlimab as a potential treatment for COVID-19, including the significance of clinical trial data and the status of CytoDyn’s FDA submissions. Pourhassan allegedly knew that leronlimab’s clinical studies failed to achieve the results needed for FDA approval, but CytoDyn continued to insist the drug could treat patients with severe disease. The FDA publicly disagreed and called out the company for cherry-picking data to suggest the therapy was a success.

“The conduct alleged in these charges erodes public trust in the safety and effectiveness of medical products, including drugs,” Catherine Hermsen, assistant commissioner of the FDA’s office of criminal investigations, said in the Dec. 20 release. “The FDA would like to extend our thanks to our federal law enforcement partners for sending a strong message to biotechnology executives and others that these types of actions will not be tolerated.”

Pourhassan and Kazempour are each charged with one count of conspiracy to commit securities fraud and wire fraud, three counts of securities fraud and two counts of wire fraud. Pourhassan is separately charged with another securities fraud charge, an additional count of wire fraud related to the COVID-19 scheme and three counts of insider trading. Kazempour separately faces one count of making false statements to federal law enforcement agents. The charges come from the work of the U.S. Postal Inspection Service Criminal Investigation group.

If convicted, each faces a maximum of 20 years in prison on each securities fraud and wire fraud count, and five years in prison for the conspiracy count. Kazempour also faces up to five years in prison for the false statements count if convicted. 

That’s not all, though. Amarex and CytoDyn are also currently tied up in a legal battle of their own, in which CytoDyn blames the CRO for “systemic issues” with the quality of data. The biotech pointed to the issues as reasoning for withdrawing its approval application for leronlimab in a specific HIV indication this October. The biotech is currently filing a claim for damages against the CRO. 

However, the ever-optimistic biotech has reaffirmed its commitments to pursuing other underserved HIV indications as well as nonalcoholic steatohepatitis and metastatic triple-negative breast cancer, where it has already secured a fast-track tag from the FDA.

The biotech continues to search for a permanent CEO in the wake of Pourhassan’s termination. Meanwhile, the biotech is helmed by President Cyrus Arman, Ph.D., who remains optimistic about leronlimab's and CytoDyn's potential.

[sumi-sprite]

Oh hell yes LETS GO!!!

Referred to as “the Dusseldorf patient” to protect his privacy, researchers said he is the fifth confirmed case of an HIV cure. Although the details of his successful treatment were first announced at a conference in 2019, researchers could not confirm he had been officially cured at that time.

Today, researchers announced the Dusseldorf patient still has no detectable virus in his body, even after stopping his HIV medication four years ago.

[ninecolors]

HIV: THE OTHER CLOSET

Imagine an unknown virus is spreading at incredible speed, causing a global pandemic that kills millions everywhere.

And now imagine that nobody cares. Nobody does anything about it. Nobody even talks about what's happening. Even worse, in many places the research into this lethal virus and possible ways to stop it are actively obstructed.

That's how the AIDS pandemic was for several decades.

World AIDS Day, held on 1 December every year since 1988, is an international day dedicated to raising awareness of the AIDS pandemic caused by the spread of HIV.

In the 40 years since the first cases of AIDS were discovered, enormous strides have been made in our knowledge of HIV and how to manage it, but there is still a great deal of work yet do be done to end the pandemic that never went away.

Thanks to the efforts of activists, scientists, and educators around the world, today a diagnosis is not necessarily a death sentence. Progress continues at an ever-accelerating pace, reaching milestones that were unthinkable only a few years ago:

U = U

With the treatments now available, a person living with HIV can have a totally normal life, including not being contagious. Yes, you read that right. When a person living with HIV receives adequate treatment, the virus is suppressed to the point that is no longer detectable in their blood: they become undetectable.

Undetectable means untransmissible. In other words, that person is not able to pass the virus to others.

PrEP and PEP

Pre-Exposure Prophylaxis (PrEP) and Post-Exposure Prophylaxis (PEP) are two kinds of medication that are highly effective in preventing the transmission of HIV. They have been made available recently, and their implementation is still limited, but these drugs are already playing a critical role in reducing transmission rates among at-risk populations.

HIV Vaccine

We have never been closer to an effective and long-lasting vaccine against HIV. Thousands of researchers and volunteers around the globe are working tirelessly to develop one. Currently the Mosaico Study is the most promising candidate.

VIHsibility

The visibility of HIV/AIDS characters in media has come a long way, both in quantity and quality. These representations are important because they have real-world impact in people's perceptions and behaviors. For example, after the success of the British show "It's a Sin", there was a significant increase in HIV testing in the UK.