#HIV research

[morningmantra]

Navigating Life with HIV: A Journey of Resilience and Hope

Navigating Life with HIV: A Journey of Resilience and Hope

Understanding HIV and AIDS HIV, or the Human Immunodeficiency Virus, is a virus that attacks the body’s immune system, the body’s defense against infections. Over time, HIV can weaken the immune system to the point where it’s unable to fight off infections and diseases. This weakens the overall health and increases the risk of developing serious infections and illnesses. AIDS, or Acquired…

[reasonsforhope]

"Five people have gone into remission thanks to advancements in medicine — and a sixth patient may also now be free of HIV.

One of the biggest breakthroughs in HIV/AIDS prevention in recent years is the widespread use of PrEP (pre-exposure prophylaxis). 

This drug therapy, approved by the Federal Drug Administration in 2012, has been a key player in preventing HIV transmission through sex or injection drug use. Antiretroviral drugs, such as PrEP, also slow the replication of the virus and prevent it from progressing to AIDS.

Although PrEP has become a more accessible treatment for the virus, scientists have been hurriedly working towards cures for HIV for decades — and we’re finally seeing some results.

In February of this year, scientists in Germany confirmed a fifth-ever patient had been cured of HIV after receiving stem cell transplants that include genetic mutations that carry a resistance to HIV. 

But it looks like a sixth patient may soon be able to join this very exclusive club. 

The man, referred to as the “Geneva patient,” underwent a stem cell transplant after cancer treatment, though these cells did not include the HIV-resistant genetic mutation. 

Still, he went off antiretroviral therapy for HIV in November 2021, and his viral load remains undetectable. 

Instead, doctors are researching whether a drug called ruxolitinib may be partially responsible for his recovery. 

Ruxolitinib decreases inflammation associated with HIV by blocking two proteins, JAK1 and JAK2. This helps kill off “reservoir cells” that lay dormant in the body and have a potential to cause rebounds in patients with HIV.

Experts say the AIDS crisis can end by 2030 across the globe — as long as leaders prioritize this goal. 

A new report from UNAIDS shows a clear, optimistic path to ending the AIDS crisis. (This looks like a 90% reduction in cases by 2030.)

The organization’s report includes data and case studies that show that ending AIDS is a political and financial choice — and that governments that have prioritized a path towards progress are seeing extraordinary results.

By following the data, science, and evidence; tackling inequality; and ensuring sufficient and sustainable funding across communities, the global community could wipe out the AIDS pandemic by the end of the decade.

The report demonstrates that progress has been strongest in the countries and regions that have the most financial investments, like eastern and southern Africa, where new HIV infections have been reduced by 57% since 2010. 

Investments in treatments, education, and access to care have also led to a 58% reduction in new HIV infections among children from 2010 to 2022 — the lowest number since the 1980’s.

Plus, the number of people on antiretroviral treatment around the globe has risen from 7.7 million in 2010 to 29.8 million in 2022.

The moral of the story? This goal can be achieved, if world leaders put their minds — and wallets — to it. 

A region in Australia might be the first place in the world to reach the United Nations targets for ending HIV transmission. 

Researchers believe that the central district of Sydney, Australia is close to becoming the first locality in the world to reach the UN’s target for ending transmission of HIV. 

Specifically, new infections among gay men have fallen by 88% between 2010 and 2022. In fact, there were only 11 new HIV cases recorded in central Sydney last year, and almost all HIV-positive Australians are on antiretroviral drugs. 

... "These numbers show us that virtual elimination of HIV transmissions is possible. Now, we need to look closely at what has worked in Sydney, and adapt it for other cities and regions across Australia.”

Namibia is ahead of schedule in UN targets to end HIV/AIDS. 

Although the virus is still the leading cause of death in Namibia, the country is well on track to hit 95-95-95 UNAIDS targets before its 2030 deadline. 

In Namibia, 92% of people know their HIV status, 99% of people living with HIV are on treatment, and 94% of people living with HIV who are on treatment are virally suppressed.

In addition to these exciting statistics, new infections have plummeted. The estimated rate of new HIV infections in Namibia is five times lower than it was in 2002, according to the Centers for Disease Control & Prevention.

These encouraging numbers are thanks to the investment and strategic response of PEPFAR, but also to the willingness of local governmental agencies and organizations to adhere to the UN’s Fast-Track approach.

Breakthroughs are being made in HIV vaccine therapies.

Long before we were all asking each other “Pfizer or Moderna?” about our COVID-19 vaccines, scientists have been researching the potential of mRNA vaccines in treating some of the world’s deadliest diseases — like HIV.

And with the success of our mainstream mRNA vaccines, an HIV inoculation remains a goal for researchers across the globe.

Last year, the National Institutes of Health launched a clinical trial of three mRNA vaccines for HIV, and similar studies are being conducted in Rwanda and South Africa, as well. 

CAR T-cell clinical trials are underway to potentially cure HIV.

This spring, UC Davis Health researchers have dosed the second participant in their clinical trial, which poses the use of CAR T-cell therapy as a potential cure for HIV.

The study involves taking a participant’s own white blood cells (called T-cells), and modifying them so they can identify and target HIV cells, ultimately controlling the virus without medication. 

The first participant in the study was dosed with anti-HIV T-cells last August, and the trial is the first of its kind to utilize this technology to potentially treat HIV. 

Of course, the trials have a long way to go, and the lab is still preparing to dose a third participant for the study, but CAR T-cell treatments have been successful for lupus and forms of cancer in the past...

“So far, there have been no adverse events observed that were related to the treatment, and the two participants are doing fine.”

Guidance on how to reduce stigma and discrimination due to HIV/AIDS is reaching people around the globe.

While the stigma surrounding HIV and AIDS has significantly decreased — especially towards the LGBTQ+ community — with advancements in treatment and prevention, discrimination is certainly not gone. 

While most people now understand HIV/AIDS better than they did decades ago, those most impacted by the virus (like gay men and low-income women and children) still face ongoing barriers to care and economic security. 

It is vital to maintain awareness and education interventions. 

After all, experts suggest that eliminating discrimination and stigma are key factors in reducing disease.  And not eliminating stigma impedes HIV services, argues UNAIDS, “limiting access to and acceptance of prevention services, engagement in care, and adherence to antiretroviral therapy.” 

Luckily, UNAIDS provides guidance on how to reduce stigma and discrimination in the community, workplace, education, health care, justice, and emergency settings. 

The goal is to, of course, decrease stigma in order to decrease disease, but also to provide folks with the culturally significant support they need to live safe, integrated lives — with or without disease. 

For instance, a 2022 study conducted in Northern Uganda showed that local cultural knowledge passed through Elders was a successful intervention in reducing HIV-related stigma among young people.

“Research in school settings has shown that the use of local cultural stories, songs, myths, riddles, and proverbs increases resilient coping responses among students and strengthens positive and socially accepted morals and values,” the study’s discussion reads. 

So, while an uptick in acceptance gives us hope, it also gives us a directive: Keep telling the accurate, full, and human stories behind HIV/AIDS, and we’ll all be better for it. "

-via GoodGoodGood, August 3, 2023

[daisiesonafield-blog]

Abstract:

Full article here

[zeddimusprime]

Trans Man Noah Diaz

The first time I saw Rise of the Beasts, I read Noah as a Trans Man, and that headcanon just solidified after my second viewing.

I’ll get the heavy reasons out of the way first, and work down to the most silly ones.

The section that was here before has been removed, because I was overstepping and someone rightly called me out on it. However. I’m not going to lie and pretend I didn’t do what I did. I deleted the comment that called me out because it made me feel bad, I panicked, and deleted it to save my own ego. It was wrong, it was cowardly, it was fucked up, and I shouldn’t have done it.

I truly am sorry, and have spent the last day sitting with myself until I stopped trying to excuse my behavior and just acknowledged what I did. I am not asking for forgiveness, I can only try going forward to be the kind of person deserving of it.

For now, I’m taking a break from this blog, leaving it on a queue, and I won’t be posting here for a while. Even though that isn’t the kind of person I want to be, I need to reckon with the fact that that is the kind of person I am. I’m sorry, once again.

1994 was also the year Don’t Ask, Don’t Tell was put into place, which, for those too young to remember, was basically a policy allowing queer and trans people to serve in the military so long as they remained closeted, and prohibited superiors from forcibly outing them. Given that we’re never actually told in the film why Noah was discharged, it’s not unreasonable to think that it may have been because he got found out as trans.

The part that’s particularly personal for me is his relationship with Kris. I’ve also got a little brother that’s quite a bit younger than me, and I acted as an extra parent to him, practically raised him since we were both latchkey kids, and yeah, there’s no doubt in my mind that I’d face the apocalypse head on if it meant keeping him safe. All that to say, it’s comforting to think that Noah’s identity as a man is inseparable from his identity as a Big Brother, the way it is for me.

Most of my other reasons are less serious:

Noah wears a lot of layers and baggy clothes on his upper half, which yes, was part of 90s fashion, but it’s also how I dressed for most of my life, even before I realized I was trans.

Noah is also non-toxically masculine in a way that’s not unheard of but also not as common for men, especially service members, of that time period. Again, there may very well be a cultural component I’m missing here, let me know if there is, but this is just something I related to as a Guy Who Wasn’t Raised As One.

This last one’s kinda silly, but I’m a Car Guy, and one of the most gender euphoria inducing things I can do is work on my car. There’s few things that make me feel like Man quite like sweat on my brow and grease on my hands and a purring engine from a job well done. So for Noah to not only be a tech wiz but specifically a Mechanic? That was the thing that really sold me on this headcanon. (And that’s not even getting into the very fun implications of Noah being the one to repair Mirage, to get to know him so intimately, literally inside and out. Very nice.)

(I also love the idea that rather than being weirded out or taken aback at first like he is in some fics, Noah would be kinda weirdly affirmed to find out that not only does Mirage have some of roughly the same *equipment* while still being treated as and being a Mech, but his setup is the norm for Cybertronians. I can so picture Noah anxiously telling Mirage about his situation when they finally get together only for Mirage to be like “you mean other human mechs don’t have a 🐈??? Like, most humans only have one or the other?????”)

[woodsfae]

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency. By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus.

[tvnacity]

if I had a nickel for every time someone came to their appointment with an untreated, dangerous, highly contagious disease and lied to us about it, saying they don’t have it, until after we’d done their whole visit and drawn their blood, I’d have two nickels. Which isn’t a lot. But it’s fucking diabolical that it’s happened twice

[dontmeantobepoliticalbut]

The Food and Drug Administration on Friday proposed easing blood donation guidelines for gay and bisexual men.

Under current rules, the FDA allows donations from gay and bisexual men if they haven't had sex with another man for three months.

In a draft proposal posted to the agency's website, the FDA said the new rules would allow anyone to donate blood — regardless of gender or sexual orientation — as long as they haven't engaged in certain sexual behaviors in the last three months.

That would mean most gay and bisexual men who are in a monogamous relationship with another man will no longer need to abstain from sex to donate blood.

"This is a great first step in getting in the right direction," Dr. Peter Marks, the director of the FDA's Center for Biologics Evaluation and Research, said on a call Friday. The new rules, he said, are consistent with those of Canada and the United Kingdom.

Under the new guidelines, blood donors who report having a new sexual partner or more than one sexual partner would be asked about their sexual activity over the last three months.

People taking oral medications to prevent HIV, such as PrEP, and people who have recently had sex in exchange for money or drugs would be subject to a three-month deferral period under the FDA proposal. Those taking injectable PrEP to prevent HIV infection would be deferred for two years from their most recent injection.

People with HIV, including those who take medication that drastically reduces their viral load, would still be asked to not donate blood.

“Maintaining a safe and adequate supply of blood and blood products in the U.S. is paramount for the FDA, and this proposal for an individual risk assessment, regardless of gender or sexual orientation, will enable us to continue using the best science to do so," FDA Commissioner Dr. Robert Califf said in a statement.

On Friday’s call, Califf said donating blood is “one of several really important symbolic methods of demonstrating one caring for other people.”

The agency's restrictions on blood donations from gay and bisexual men stem from the AIDS crisis, which began in the early 1980s, when little was known about the virus.

As of 2019, an estimated 1.2 million people in the United States had HIV, according to the Centers for Disease Control and Prevention.

Advocacy groups and medical organizations, including the American Red Cross, have urged the FDA to lift restrictions on blood donations for gay and bisexual men, saying the practice is discriminatory and has contributed to shortages in the blood supply in the United States.

A report from the Williams Institute, a think tank at UCLA School of Law, found that if the FDA were to lift donor bans for men who have sex with men, the annual blood supply would increase by 2 to 4%, or 345,400 to 615,300 pints of blood annually.

The FDA is not expected to reach a final decision until after a 60-day public comment period.

Marks, of the FDA, said the agency plans to work with blood collectors during the comment period to help them make any necessary changes needed to implement the new rules.

[jedibongrip]

What's your writing about HIV for?

a grade

[ocdhuacheng]

No offense but thinking about the possible long term risks of covid and how literally no one seems to care about it makes me fall into a fit of despair. In ten years when we are all dropping like flies I’m going to say I told you so with my last goddamn breath. See you in fucking hell Karen

[powerofpets]

New research investigates whether pet ownership impacts healthcare access in people living with HIV.

Read the full story here 👉

[soumyafwr]

https://connected.linkspreed.com/read-blog/54966_hiv-or-aids-drugs-market-size-analysis-and-forecast-2031.html

Hiv or Aids Drugs Market Size, Analysis and Forecast 2031

[reasonsforhope]

"The “Düsseldorf Patient”, a man now aged 53, is just the third person worldwide to have been completely cured of HIV via stem cell transplantation.

As in the case of the other two patients, the so-called “Berlin Patient” and “London Patient,” the transplantation was undertaken to treat an acute blood disease, which had developed in addition to the HIV infection.

The Düsseldorf Patient received a stem cell transplant used to treat leukemia in 2013 and has shown persistent suppression of HIV-1 ever since, including during the last 4 years after the patient stopped taking anti-retroviral medication.

“I still remember very well the sentence from my family doctor: ‘don’t take it so hard,'” the Düsseldorf Patient, who had leukemia as well as HIV-1, said in a statement. “‘We will experience together that HIV can be cured!’ At the time, I dismissed the statement.”

Allogeneic hematopoietic stem cell transplantation (HSCT) is a procedure used to treat certain cancers, such as leukemia, by transferring immature blood cells from a donor to repopulate the bone marrow of the recipient.

Scientists now understand that individuals with two copies of the Δ32 mutation in the gene for the HIV-1 co-receptor CCR5; are resistant to HIV-1 infection. The two previous cases of both the London patient and the Berlin patient involved receiving a stem cell transplant from a donor with these unique mutations.

Björn-Erik Jensen, a specialist in infectious diseases at Düsseldorf University Hospital, lead the treatment and subsequent research, revealed today in a peer-reviewed study in Nature.

The patient was diagnosed as having acute myeloid leukemia and proceeded to undergo transplantation of stem cells from a female donor in 2013, followed by chemotherapy and infusions of donor lymphocytes.

After the transplantation, anti-retroviral therapy was continued, but HIV was undetectable in the patient’s blood cells. Anti-retroviral therapy was suspended in November 2018 with the patient’s informed consent, almost 6 years after the stem cell transplantation, to determine whether the virus persisted in the patient.

“I very much hope that these doctors will now get even more attention for their work,” said the patient. “I have now decided to give up some of my private life to support research fundraising. And of course, it will also stay very important for me to fight the stigmatization of HIV with my story.”

The authors conclude that although HSCT remains a high-risk procedure that is at present an option only for some people living with both HIV-1 and hematological cancers, these results may inform future strategies for achieving long-term remission of HIV-1."

-via Good News Network, 2/20/23

VERIFIED 10 YEARS ON, PROOF THAT HIV IS CURABLE

[grounded-gryphon]

This is huge!

Usually when news of a new HIV 'breakthrough' comes through, it's all hot air about a stage 1 trial that will never go anywhere.

This is not that.

This is a real, honest-to-god BREAKTHROUGH on a phase 3 trial that could prevent thousands of infections. This is the biggest news since PrEP was first announced.

Be excited!

[borom1r]

Like it really does just speak to the power of music in film. I really would love to know the thought process. also genuinely sitting here torn between “nothing about the Hitcher could ever be good representation” and “they really went ‘we can’t have John Ryder become homicidally obsessed with a MAN, that was weird in the 80s.’” im. hello? it’s dark in here.

[hiv-live-laugh-love]

like i know hiv is like technically not the gay person disease or the black african disease but like assertions of this fact ring hollow to me

[captainjunglegym]

.