#Good as fuck game. Good as FUCK game.

[internetskiff]

SIGNALIS SPOILERSSS GO PLAY IT GO PLAY IT IT'S THE BEST SURVIVAL HORROR GAME I'VE EXPERIENCED ... ... ... ... ... ...

I've immediately begun a second playthrough after my first blind one and I've realized something that's probably extremely obvious in hindsight but

technically this is the moment Adler lets it slip that he knows about the loop. He's asked Elster for the picture before she even revealed she had it. He's quite an interesting character to me since it seems like he's the only one who's both aware of the loop and not going insane, or, well, going insane in a different way. Every other Replika's either turned mindless or obsessive but he's still trying to make sense of the loop, and even seemingly trying to maintain it.

Maybe my view of the story is still incomplete since I found out there's more to the game I've yet to see (so far I've only gotten the 'Memory' ending), but what would happen if the loop breaks? Why is Adler so afraid of it? If this is a dream reality, is he afraid that the moment Ariane wakes Sierpinski gets erased from existence? Or, at the very least, this extremely warped perception of the facility?

Also, there's this moment that I can't stop thinking about. I genuinely can't tell if I just didn't take a look at this key before or if Alina's pass photo changed to make her look wounded like this on the second playthrough. I might've just taken the key and booked it because the EULR enemies creeped me out. I think she and Adler are the only people to ever mention seeing an LSTR at Sierpinski, so I'm wondering if they were both just driven mad by bioresonance or if there really was one at the facility at some point. The way Alina talks about her makes it sound as if she was stationed at the facility for a while. Is she just being bombarded with Ariane's memories? Judging from how she mentions off-handedly about feeling sick and she's covered in that many bandages, I assume she was suffering from the same radiation poisoning-like symptoms as everyone else. Genuinely can't stop thinking about this game's story. It feels like absolutely everything connects in some way. It's so fucking good. Apologies if I got anything wrong from what I've gathered so far, trying to be more thorough when it comes to looking at the finer details on the second playthrough. Playing this game mostly blind was the best decision I made, makes me adore every second of it even more.

[mintaii]

take responsibility

[yuri-hell-world]

THIS SPACE LEFT INTENTIONALLY BLANK

[chiangyorange]

the chain but on a scale of who says hooray yippee and wahoo

is this anything.

[musubiki]

balor 🥰

[egophiliac]

do skully have pokemon?

Pumpkaboo is the obvious one, but y'know, sometimes the obvious one is the right one! (we'll say SUPER SIZE Pumpkaboo, just for fun. big pumpkin for big skeleton boy.) and another person actually also suggested Greavard, which I somehow hadn't considered, but feels so perfect that I feel like I should have. dangit.

(they can also have little Nightmare Suit costumes :D)

[girlwiththegreenhat]

team fortress 2 finally getting rid of the bots after 5 years

work on the team fortress 2 comic continuing after 7+ years

half life 3 development looking more likely than ever with legitimate code, file, and voicework leaks referencing a new non-VR single-player game from valve featuring a HEV suit wearing protagonist and Xen creatures and concepts

shoutout to the valve fan that found the genie lamp. you a real one

[giselles-dumping-hat]

So Act 3 is going great,

[1982brucespringsteen]

some good news!! the spanish state's ministry of equality has finally passed one of the most progressive trans laws on the planet, shielded free and universal access to abortion and banned conversion therapy and genital surgery for intersex babies, among a lot of other feminist policies. the minister of equality irene montero gave a speech thanking spain's lgtb and trans associations for helping her draft these legislations. couldn't be more proud!!

[saragrosie]

I was ltr just drawing them in swapped outfits cuz ya know disco is canon in Yakuza 0 and then bam they fucking Harry Du Bois'd Majima and ive never been more hyped for a video game in my life

Expect to see more of this in non shitpost style (yes I lowered the graphics on kiryu and majima im tired) bc I love disco fashion and RGG and DE <3

[wyrmswears]

??lego ninjas

[reasonsforhope]

"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.

The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.

Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.

Tell us about the trial and what it set out to achieve

The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.

Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.

The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.

The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.

Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...

The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.

In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.

By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...

What is the significance of these trials?

This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.

There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...

For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.

HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.

For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.

What happens now?

The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.

They will be offered the choice of PrEP they would prefer as the trial continues.

A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.

It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.

How long until the drug is rolled out?

We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.

The World Health Organization will also review the data and may issue recommendations.

We hope then that this new drug will be adopted into WHO and country guidelines.

We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.

Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.

Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.

In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."

-via The Conversation, July 3, 2024

[medicalunprofessional]

ohhh hell yes

[bananafire11]

Tadc..... dinosaurs.... tadc dinosaurs

[channnel]

What if they were friends 🥹

[humming-fly]

Delighted to discover that the way shadow unlocks new abilities in sxsg is a perfect parallel of the pringles iron maiden