#GBM treatment

[bpod-bpod]

Seeing Progress

Glioblastoma (GBM) is the most intractable and fatal type of brain tumour and models to aid study towards better treatment are urgently needed. Here, a genetically-relevant zebrafish model of aggressive human GBM which, thanks to the transparency of the developing fish body, enables live imaging and presents a means of high-throughput genetic and molecular manipulations towards therapeutic discovery

Read the published research article here

Today – 17th July 2024 – is Glioblastoma Awareness Day

Read here about the OurBrainBank initiative, the research and data collection community with a mission to turn GBM from terminal to treatable

Image from work by Alex Weiss and colleagues

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife (reviewed reprint), July 2024

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[kkumarsblog]

Glioblastoma Multiforme Market Overview: Insights from DelveInsight

Glioblastoma Multiforme (GBM) is an aggressive and highly challenging brain cancer originating from glial cells. Known for its rapid progression, high recurrence rates, and resistance to conventional treatments, GBM remains a critical focus for researchers and healthcare professionals.

Despite the challenges, the Glioblastoma Multiforme market is evolving, driven by continuous advancements in treatment strategies and the introduction of novel therapeutic agents. This article explores the GBM treatment market, therapeutics market, drugs market, and the key companies shaping the industry.

Glioblastoma Multiforme Drugs Market Overview

GBM is the most common and aggressive primary brain tumor in adults, classified as a Grade IV glioma by the World Health Organization (WHO). It typically affects individuals aged 45-70 years and is more prevalent in men. The average survival time post-diagnosis is approximately 15 months, with a low five-year survival rate.

The tumor's heterogeneity makes treatment complex, as it exhibits rapid cell division, abnormal blood vessel growth, and resistance to traditional therapies. Despite medical advancements, the prognosis remains poor, underscoring the urgent need for innovative and effective therapies.

Glioblastoma Multiforme Treatment Market

The GBM treatment market is driven by the demand for therapies that can enhance survival rates, lower tumor recurrence, and improve patients’ quality of life. The standard approach combines surgery, radiation therapy, and chemotherapy, though the tumor's aggressive nature poses significant challenges.

Current Treatment Options

Surgical Treatment: Surgery is the primary intervention to remove as much of the tumor as possible while preserving healthy brain tissue. However, due to its infiltrative nature, complete removal is difficult, leading to recurrence.

Radiation Therapy: Following surgery, radiation therapy is commonly used to destroy remaining cancer cells. External beam radiation is the preferred method, though targeting tumors without harming healthy tissues remains a challenge.

Chemotherapy: Temozolomide (TMZ) is the most widely used chemotherapy drug for GBM. It works by damaging cancer cell DNA, but resistance to TMZ limits its long-term effectiveness.

Despite these treatments, the median survival rate remains 15-18 months, emphasizing the need for breakthrough therapies.

Glioblastoma Multiforme Therapeutics Market

The GBM therapeutics market is rapidly evolving, with promising innovations in targeted therapies, immunotherapies, gene therapy, and nanotechnology.

Key Therapeutic Advancements

Targeted Therapy: Focused on specific cancer-driving mechanisms like epidermal growth factor receptor (EGFR), angiogenesis, and DNA repair pathways.

Bevacizumab (Avastin): An anti-angiogenic therapy approved for recurrent GBM, limiting tumor blood vessel growth.

Immunotherapy: A growing area utilizing the immune system to combat GBM.

CheckMate-143 Trial: Studying nivolumab (Opdivo), an anti-PD-1 immune checkpoint inhibitor, in combination with temozolomide.

DCVax: A cancer vaccine stimulating the immune system to attack tumor cells.

Gene and Stem Cell Therapy: Investigating oncolytic viruses and gene-modified T-cell therapies to correct cellular abnormalities in GBM.

Nanotechnology: Nanoparticles are being engineered to deliver drugs across the blood-brain barrier (BBB), enhancing effectiveness and minimizing side effects.

Glioblastoma Multiforme Drugs Market

The GBM drugs market is witnessing the development of innovative therapies aimed at addressing unmet medical needs.

Key Drugs in the Market

Temozolomide (TMZ): The current standard-of-care chemotherapy, though its effectiveness is limited due to resistance.

Bevacizumab (Avastin): Targets angiogenesis and is used primarily for recurrent GBM.

Nivolumab (Opdivo): An immune checkpoint inhibitor undergoing clinical trials to improve GBM treatment outcomes.

Investigational Drugs: Idasanutlin, ABT-888, and Olaratumab are being tested in combination therapies for enhanced efficacy.

Glioblastoma Multiforme Companies

The GBM market is competitive, with leading pharmaceutical and biotechnology companies investing in R&D to develop innovative therapies.

Key Companies

Genentech: Developer of Bevacizumab (Avastin), a key targeted therapy for GBM.

Bristol-Myers Squibb: Advancing nivolumab (Opdivo) in GBM clinical trials.

Eli Lilly: Investigating Verzenio in combination treatments.

Novocure: Pioneering Tumor Treating Fields (TTF) technology, disrupting cancer cell division.

Sarepta Therapeutics: Researching gene therapy and personalized medicine for GBM.

Conclusion

The Glioblastoma Multiforme market is poised for transformation with advances in targeted therapies, immunotherapies, and nanotechnology-driven drug delivery. While current treatments remain limited, ongoing research and clinical trials offer hope for improved survival rates and quality of life for patients.

As new therapies emerge and personalized medicine progresses, the GBM treatment landscape is set to evolve, with the potential for a breakthrough treatment in the near future.

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Contact Information

Kanishk

kkumar@delveinsight.com

[vikas-009]

Enhance Your Production with Advanced Pre-Treatment Plants | GBM Industrial

Looking to optimize your industrial production process? GBM Industrial Ovens offers state-of-the-art pre-treatment plants designed to enhance efficiency, improve product quality, and streamline your operations. Our innovative solutions are tailored to meet the demands of various industries, ensuring durability, precision, and exceptional performance. 

Explore our cutting-edge technology today and take your production to the next level!

Read more : Pre-Treatment Plant Manufacturer In India | GBM Industries

[credenceresearchdotblog]

The Glioblastoma Treatment Drugs Market is projected to grow from USD 2665 million in 2024 to an estimated USD 5589.2 million by 2032, with a compound annual growth rate (CAGR) of 9.7% from 2024 to 2032. Glioblastoma multiforme (GBM) is the most aggressive and common type of primary brain tumor in adults. Known for its rapid progression and resistance to standard therapies, GBM presents a significant challenge to healthcare professionals and researchers worldwide. The growing prevalence of glioblastoma, coupled with advancements in oncology, has spurred significant developments in the glioblastoma treatment drugs market.

Browse the full report at https://www.credenceresearch.com/report/glioblastoma-treatment-drugs-market

Market Overview

The glioblastoma treatment drugs market is experiencing steady growth, driven by the increasing incidence of GBM and rising investments in cancer research. According to recent statistics, the global glioblastoma treatment market was valued at approximately USD 2.1 billion in 2022 and is projected to grow at a compound annual growth rate (CAGR) of around 8% during the forecast period of 2023–2030.

Current Treatment Options

The primary treatment for glioblastoma typically involves surgical resection, followed by radiation therapy and chemotherapy. Temozolomide (TMZ), an oral alkylating agent, remains the gold standard chemotherapy drug for GBM treatment. However, the recurrence of glioblastoma post-treatment remains a critical concern.

To address these challenges, several new drugs and therapeutic approaches are entering the market, including:

Targeted Therapies Drugs targeting specific molecular pathways, such as EGFR (epidermal growth factor receptor) inhibitors, have shown promise. Agents like bevacizumab, an anti-VEGF (vascular endothelial growth factor) monoclonal antibody, are being used to control tumor angiogenesis and prolong progression-free survival.

Immunotherapies Immunotherapy has emerged as a game-changer in oncology. Immune checkpoint inhibitors, cancer vaccines, and adoptive T-cell therapies are being explored to harness the body’s immune system to fight glioblastoma. Clinical trials of drugs like nivolumab are underway, aiming to improve patient outcomes.

Gene and Cell-Based Therapies Advances in gene editing and cell-based therapies have paved the way for personalized medicine in glioblastoma treatment. Oncolytic viral therapies, which use genetically modified viruses to target cancer cells, are gaining traction in research and development pipelines.

Challenges in the Market

Despite significant progress, the glioblastoma treatment drugs market faces several hurdles:

High Costs: Advanced therapies often come with a hefty price tag, limiting access for many patients.

Complex Biology of GBM: The heterogeneity and adaptability of glioblastoma tumors make them highly resistant to treatment.

Regulatory Barriers: Stringent approval processes for new drugs can delay market entry.

Future Outlook

The future of the glioblastoma treatment drugs market looks promising, driven by ongoing research and technological advancements. The integration of artificial intelligence and big data analytics in drug discovery is expected to expedite the development of effective treatments. Additionally, combination therapies that incorporate multiple approaches—such as chemotherapy, immunotherapy, and gene therapy—are likely to emerge as the new standard of care.

Government initiatives to support cancer research and increasing funding from private organizations further bolster the market’s growth potential. However, addressing the affordability and accessibility of these advanced treatments remains crucial to ensuring better outcomes for patients worldwide.

Key Player Analysis:

Amgen, Inc.

Amneal Pharmaceuticals

Arbor Pharmaceuticals, LLC

AstraZeneca PLC

Hoffmann-La Roche Ltd.

Gene Therapy

GlaxoSmithKline plc (GSK)

Glioma Steam Cell Targeting

Johnson & Johnson

Karyopharm Therapeutics, Inc.

Kinase Inhibitor

Merck & Co., Inc.

MiRNA Targeting

Novartis AG

Pfizer Inc.

Roche Holding AG

Sanofi S.A.

Sun Pharmaceutical Industries Ltd.

Teva Pharmaceutical Industries Ltd.

Segmentation:

By Treatment 

Surgery

Radiation Therapy

Chemotherapy

Targeted Therapy

Tumor Treating Field (TTF) Therapy

Immunotherapy

By Drug Class:

Antineoplastic

VEGF/VEGFR Inhibitors

Alkylating Agents

Miscellaneous Antineoplastic

By Distribution Channel:

Hospitals

Cancer Research Organizations

Long Term Care Centers

Diagnostic Centers

By Region:

North America

U.S.

Canada

Mexico

Europe

Germany

France

U.K.

Italy

Spain

Rest of Europe

Asia Pacific

China

Japan

India

South Korea

South-east Asia

Rest of Asia Pacific

Latin America

Brazil

Argentina

Rest of Latin America

Middle East & Africa

GCC Countries

South Africa

Rest of the Middle East and Africa

Browse the full report at https://www.credenceresearch.com/report/glioblastoma-treatment-drugs-market

Contact:

Credence Research

Please contact us at +91 6232 49 3207

Email: sales@credenceresearch.com 

[themalriclabs]

Nanotechnology in Neuro-Oncology: Targeted Drug Delivery for Glioblastoma Multiforme (2019)

ABSTRACT.

This paper explores the advancements in nanomedicine to address the challenges of treating glioblastoma multiforme (GBM), an aggressive and treatment-resistant brain tumor. The study focuses on the use of nanocarriers, such as liposomes, polymeric nanoparticles, and dendrimers, to enhance the precision and efficacy of drug delivery across the blood-brain barrier. By utilizing nanoscale targeting mechanisms, including surface modifications and ligand-receptor binding, these systems improve the delivery of chemotherapeutic agents directly to tumor sites while minimizing systemic toxicity. Preclinical and early clinical results indicate a significant increase in drug bioavailability and tumor uptake, along with reduced adverse effects. This article highlights nanotechnology's transformative potential in neuro-oncology and provides a foundation for future research toward personalized and effective GBM treatment strategies.

[rohit-buzzz-creater]

Top Drying Oven in India - GBM Industries 🏭

Looking for the best drying oven in India? GBM Industries is your trusted partner for high-performance and durable drying solutions. 🏭 Our ovens are perfect for various industrial applications like curing, drying, and heat treatment, ensuring precision and energy efficiency. 🚀 Take a next step - Visit Our Latest PPT : Top Drying Oven in India - GBM Industries

[teejeepclothes]

Official Kansas Jayhawks School Of Medicine Shirt

Official Kansas Jayhawks School Of Medicine Shirt Glioblastoma (GBM). GBM is the most Official Kansas Jayhawks School Of Medicine Shirt and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

[limoteesese]

The Grinch Stole Indianapolis Colts Ball Blue Womens Ugly Christmas Sweater

The Grinch Stole Indianapolis Colts Ball Blue Womens Ugly Christmas Sweater

Glioblastoma (GBM). GBM is the most The Grinch Stole Indianapolis Colts Ball Blue Womens Ugly Christmas Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

[vikas-09]

Belt Conveyor Oven by GBM Industries: A Comprehensive Overview 🔥🏭

The Belt Conveyor Oven by GBM Industries is a cutting-edge solution designed to enhance production efficiency in various industries. This oven is ideal for continuous heat treatments, such as drying, curing, and baking, where components move seamlessly on a conveyor belt through different heating zones. Whether it's for automotive, electronics, or food production, this oven ensures consistent and controlled heating.

Key Features:

🔄 Continuous Operation: Streamlines production by automating the transport of parts through the oven.

🌡️ Precise Temperature Control: Multiple heating zones ensure even distribution of heat for optimal results.

⚡ Energy-Efficient Design: Built with insulation and energy-saving features, reducing operational costs.

🛡️ Safety Features: Includes emergency shutdown systems, overheating protection, and proper ventilation for safe operations.

For more details, check out GBM Industries' website! 🌍

[vikas-009]

Pre-Treatment Plant: Essential for Effective Surface Treatment

Discover how a Pre-Treatment Plant enhances metal surface preparation for superior coating and durability. GBM Industries provides high-quality solutions for various industries. Learn more about the process, benefits, and applications in our latest blog!  

👉 Read now: Pre-Treatment Plant Manufacturer In India | GBM Industries

[medicomunicare]

Aminoacids and fats meet for "malignant" purposes: reexploring antipsychotic drugs paving the way for metabolic wreck

Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy treatments, the two-year survival rate for GBM patients is less than 10%. Two major challenges hinder effective treatment: the limited penetration of anti-tumor drugs into GBM tissues because of the blood-brain-barrier; and the rapid…

[teejeep-shirt]

Tampa Bay Rays take October 2024 Postseason shirt

Tampa Bay Rays take October 2024 Postseason shirt Glioblastoma (GBM). GBM is the most Tampa Bay Rays take October 2024 Postseason shirt and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

[crimsonpublisherscancerstudy]

Recent Advances in the Therapeutic Approaches of Glioblastoma Multiforme_Crimson Publishers

Abstract

Glioblastoma Multiforme (GBM, WHO grade IV) is one of the most aggressive, invasive, and lethal intracranial neoplasms, with a low post-diagnosis survival rate. Standard-of-care treatment regimens involving maximal surgical resection, radiotherapy, and genetic anti-tumor compounds like Temozolomide have only been marginally effective in improving overall survival and quality of life. Cell fusion, autophagy, and other complex biological processes affecting GBM pathophysiology are being studied to improve GBM treatment. This paper therefore focuses on oncolytic virus therapy combined with surgical resection, photodynamic therapy, and novel gene therapy, demonstrating how GBM treatment for patients could result in immediate and authentic tumor cytotoxicity and removal, rather than treatment of recurrent GBM. Standard therapy for GBM, including surgery, radiotherapy, and chemotherapy, is called the Stupp regime with the inclusion of Temozolomide (TMZ). It is extremely difficult to design new and effective therapeutic approaches because of the numerous complex biological pathways involved in GBM pathogenesis. Even Stupp regime clinical outcomes have only shown modest benefits with less than 10% of overall 5-year survivorship. A major contributing factor in GBM development is also its interaction with the patient’s host immune system.

Read more about this article:

For more articles in Novel Approaches in Cancer Study

[rnomics]

Pharmaceutics, Vol. 16, Pages 829: Targeting Intracranial Tumours with a Combination of #RNA and Chemotherapy

Glioblastoma multiforme (GBM) is a fast-growing and aggressive brain tumour, which remains largely resistant to treatment; the prognosis for patients is poor, with a median survival time of about 12–18 months, post diagnosis. In an effort to bring more efficacious treatments to patients, we targeted the down regulation of ITCH, an E3 ligase that is overexpressed in a variety of #cancers, and which inhibits P73, a tumour suppressor gene. 6-O-glycolchitosan (GC) was used to deliver #siRNA ITCH (GC60-#siRNA-ITCH) and gemcitabine via the nose to brain route in CD-1 nude mice which had previously been implanted intracranially with U87-MG-luc2 cells. Prior to this in vivo study, an in vitro study established the synergistic effect of #siRNA-ITCH in combination with a chemotherapy drug—gemcitabine. A downregulation of ITCH, an upregulation of p73 and enhanced apoptosis were observed in vitro in U87-MG cells, using qPCR, Western blot analysis, confocal laser scanning microscopy, flow cytometry and cytotoxicity assays. When GC60-#siRNA-ITCH was combined with gemcitabine, there was a resultant decrease in cell proliferation in vitro. In CD1 mice, the administration of #siRNA-ITCH (7 doses of 0.081 mg/kg) alone did not significantly affect animal survival (increasing mean survival from 29 to 33 days when compared to untreated animals), whereas intranasal gemcitabine had a significant effect on survival (increasing survival from 29 to 45 days when compared to untreated animals, p < 0.01). The most significant effect was seen with combination therapy (GC60-#siRNA-ITCH plus gemcitabine), where survival increased by 89%, increasing from 29 to 54 days (p < 0.01). Our data demonstrate that #siRNA chemosensitises brain tumours to gemcitabine and that the nose-to-brain delivery route may be a viable route for the treatment of intracranial tumours. https://www.mdpi.com/1999-4923/16/6/829?utm_source=dlvr.it&utm_medium=tumblr