#FULLTEXT

[pulipuli]

看看網頁版全文 ⇨ 安裝支援單字詞搜尋的Omeka-S / Install Omeka-S with Single Token Fulltext Seach Feature https://blog.pulipuli.info/2023/04/blog-post_375.html 沒想到一開始就不應該選擇MariaDB。 ---- # 安裝步驟記錄 / Installation steps。 這邊我只是簡單記錄一下整體的安裝步驟。 首先是環境。 我在Proxmox VE 7.2-3以CT形式安裝，CT範本是ubuntu-22.04-1_amd64.tar.zst。 開機後安裝必要元件： [Code...] 啟用Apache的rewrite模組： [Code...] ## 啟用.htaccess / Enable .htaccess。 為了啟用.htaccess，我們需要修改Apache設定檔：。 [Code...] 找到，將底下的AllowOverride None改為AllowOverride All。 完成後需要重新啟動Apache： [Code...] ## 設定資料庫 / Database Setup。 再來是設定MySQL資料庫。 在Bash裡面輸入以下指令：。 [Code...] 接著要設定密碼。 現在MySQL對密碼要求很嚴格，不能使用常見的單字。 設定的密碼足夠複雜的話，就能夠設定成功，不然就得要一直重試。 設定成功後，用以下指令進入mysql： [Code...] 在mysql的終端介面輸入以下三個指令，表示建立資料庫，並將資料庫的權限給root，然後離開：。 [Code...] ## 設定資料庫的ngram / ngram configuration of MySQL。 接著要修改資料庫的全文檢索斷詞設定檔案。 開啟MySQL資料庫的設定檔：。 [Code...] 在最後加上以下設定： [Code...] 然後重新啟動MySQL即可： [Code...] ---- # Omeka S安裝 首先先下載Omeka S檔案： [Code...] 解壓縮： [Code...] ## 資料庫設定 / Database setup。 修改資料庫設定： [Code...] 使用者user設定root、密碼password為剛剛建立的密碼、資料庫名稱dbname為omekas、連線位置host為localhost。 ## files權限設定 / Enable write permission of "files" folder。 再來啟用files資料夾的寫入權限。 指令如下：。 [Code...] ---- 繼續閱讀 ⇨ 安裝支援單字詞搜尋的Omeka-S / Install Omeka-S with Single Token Fulltext Seach Feature https://blog.pulipuli.info/2023/04/blog-post_375.html

[lordmattuk]

I have now added search to my directory

Here is some news for the three or four people aware of my directory project. For those reading this that have not heard yet – I have been working on a directory of the very best bits of the Internet. As sections mature (and I figure out what I am doing), I will create GitHub repositories where anyone can contribute entries. Each entry is an XML file carrying all the data needed to display it…

[popodoki]

You absolutely know I am going to be giving the Cat King his moment in the fencing fic, you know it has to be done

He's going to tip Edwin's chin up with the tip of his sabre

fellas is it gay of course it is

[sanct1f1ed]

hi

[relto]

sure ive mentioned it before, but i love query so so much. the flight rising color schemer went offline, so i set about making my own thing, inside a spreadsheet bc its faster. i can assemble id lists like this:

and with a single query call (!!) make a list:

edit: just saw it reorders colors by id which we dont want here. so double query flatten it is:

now ranges that cross zero will properly be continuous.

[mikansei]

Ohh this articulates so well a thought I've had about regional/temporal/subcultural etc. details like this in fic!

It's hard to recall specific instances - when done well, it blends seamlessly and doesn't stick out. I'm always trying to achieve this in my fics while also tempering my need to describe everything in excruciating detail, lol. Paring away the result of an hours-long research binge like gently peeling an apple...

(Wikipedia's blue links are dangerous stuff 😭 like a gacha except the prize is learning trivial shit about everything under the sun for free)

When done well it's a great way to ground a character within their own world and humanize them, rather than just pasting a reference like a sticky note on top the narrative. One way to do it is to get less specific - per the example, not naming Naruto specifically and generalizing to just "anime," so the reader can mentally fill in whichever series they feel might fit. Still gets the gist across without potentially revealing the author's personal taste in Ao3 reading material, lol.

But making it less specific isn't necessarily the best way, you know? Especially for a character who might reasonably know the specific thing being referenced.

Something I'm currently running up against in my fic: the Visored have lived in the Material World since 1901, and are all at least a little tuned-in to human culture - Rose & Shinji's love of music (despite the slight anachronism of jazz in 1901 lol), everyone's fashion, etc. Rose is more classical-themed (his outfit & Kinshara's conductor's baton), so for actual in-text references I'm sticking to classical music: he complains about Shinji making him play the boring bass part of Pachelbel's Canon in D. (Totally not channeling my former band kid woes here...)

Would it be unfitting to mention him singing something more contemporary? Not necessarily. Does naming a modern song directly in the fic feel like transporting myself back in time to 2003 songfic on FF.net? YES 💀

I don't have like, a solution here, lol. In lieu of specific references that might ring false or forced, I've been trying to focus on the non-specific - the reactions, the feelings, the vibes other characters are getting from Rose as "that one friend of yours who bursts into showtunes at any given opportunity." He is That Guy™ who starts singing in the group call and makes everybody groan, not because he's a bad singer, but because this is the third song he's sung in the past half hour alone. They have been down this road before. A lonely road; the only one that they've ever known--

*I am pulled offstage Vaudeville-cane-style*

Another way to make the setting feel like a lived-in place that the characters actually occupy is inventing things for them to do (or avoid), events for them to take part in (or not) - but the trick is to keep it conversational. If the character's talking about a local festival in their hometown, even in narration, they're probably not describing the whole shebang down to the history of when it was first celebrated. Because they're already familiar with it, you can flex their voice by summarizing what about it would be important to them. Maybe it's "You know, that thing where a noisy crowd makes navigating main street hellish for three days," or "Right, the 'festival' - or as I like to call it, 'an excuse to be publically day-drunk all weekend'."

(Bonus: doing that means you don't have to come up with details, lmao.)

Verisimilitude (long thoughts about writing)

Sometimes I get mailed random books to consider for course adoption. The first one I looked at the other day was so incredibly bad I could not make it past page 12--"oh my god I hate books" bad; "trees were wasted on this!!" bad. And then there's this one. I've made it to page 30-something and I could have told you 20 pages ago that Oliver Twist it would remain, but I am still reading it to read it, and maybe keep it to recommend extracurricularly. (The protagonist Alva is a weeb for American culture, whatever the word is for that, which I think could make for interesting study!) But that's all context to say,

AH YES THE INTERNET RABBIT HOLE OF NARUTO FAN FICTION, HENTAILORD. WE'VE ALL BEEN THERE.

SO...

BLEACH MENTION WHEN????

Based on the style of her screen name, the Naruto porn, and her listening to My Chemical Romance and Linkin Park, this girl is definitely living her teenage life in the mid-00s, in ways that are searingly obvious. Which feels like it should be a massive success in terms of using verisimilitude to pinpoint a particular time and place and, by extension, person. But I don't think it does?

In thinking about why this doesn't work for me as a reader:

1. As a general rule, I tend not to enjoy "fandom" subculture references like this in fiction, because they have never felt true to my experience of fandom, or even my experience of others' experiences of fandom. The specificity is there but not the verisimilitude. Whether this is because of an inability to articulate the breath of life that animates fandom spaces, or a feeling of needing to at least kind of translate it for the uninitiated general audience, I don't know. Not that Alva's narrative goes far enough to merit this discussion; she's just reading Naruto porn for one sentence, but it just doesn't land right for me. (Sidebar, this is probably also why I don't enjoy acafandom or fandom essays that aspire to acafandom; there's usually this attempted, manufactured critical/"objective" distance from the text that often feels performative, or at least the wrong [or less interesting] tool for the job. And even where 'in-group' positionality is addressed, the translation required to make these things legible to the out-group is just--well, not what I want in life, I guess!)

2. I am a great believer in drawing greatly from what you know and feel and all those random thoughts and behaviors and emotions and tics that make life interesting, and giving them to fiction. In fanfic especially, I am a great believer in seeing the author's hands in a text, making the story (and the original canon) unmistakably theirs. But I kind of always want them to be hands that are in the act of giving. By which I mean, I think there's a difference between all these things existing in a story and having been given to a character or a world or a story, and integrated genuinely into them.

Like, all I can think about while reading this book is how the author definitely lived through the mid-00s in a particular and very familiar way. Rather than create a richly immersive world, the details jump out of the page and leave the story behind. They don't feel like they belong to Alva (or perhaps Alva does not feel like a character with the depth to hold them and make them hers). They belong do the author, and to me, and to history, but Alva falls out of the equation. And if this is going to work, I feel like Alva can't fall out of the equation.

3. I was talking to a friend about something similar a few months ago. She was complaining about a historical fiction book she was reading with a book club she leads at the library she works at--how it was clearly very well-researched, but dry as hell. The information was not animated by the story itself. And I compared it to a fanfic I'd (not) read, where the author was very proud of all the research they'd done and how accurate-to-life its setting was. (To be clear, I'm not subtweeting Bleach fandom. Completely different fandom! Also this fanfic was published like 16 years ago.) The fic did bring in lots of specific details about trees and highways and city names--things I knew well, too, because it was set where my sister lives--but rather than be as exciting and, again, rich, as I feel like that familiarity could have been, it all felt dead. Because all these things were described specifically, but not true to how the narrating characters would describe them, or mentally catalogue them, or experience them.

And you might think, well, how would we possibly know how a character thinks about highways? It's not like he's explained this in canon. And I'd say, well, you definitely can. There are probably a lot of different ways a character could plausibly think about highways, depending on the specific shade and flavor of your characterization of them, all equally believable; but it's got to be part of the equation. There are a lot of ways to be right, and you know it when it's wrong. The wrong-est way it can be is for the way they think about highways to not factor into the way those dang highways are being described by them, in their POV.

4. I think about this both as a reader and as a writer--certainly more often as a writer, because I find that level of imagining a character's headspace the VERY best part of the process, and also because I am often concerned I am not doing it, or at least not well, lol. I'm positive I've done all the things I've just talked about not enjoying.

These concerns exist at the level of characterization work in general, but also at that level of, is the wizard behind the green curtain? Are his hands giving? Because while I do write fanfic because "it is fun" and because "this idea interests me," I am also usually writing it to work through deeply personal emotions/experiences. Which again, perhaps selfishly, I support that. But from a craft perspective I don't want it to feel, transparently, like "oh lol this author is going through it."

Moreover, from a relational perspective, I don't want that to be the relationship between me as author and the characters. Because one thing I am ALWAYS writing fanfic to do is to indulge my feelings about how much I am in complete, rapturous love with the characters and worlds in question. I don't want to just place things upon them, like a film or shroud; I want them to be given, integrated, arriving in the text wholly in their bodies and in their minds and entirely theirs. And I mean this for both the emotional arcs and conflicts and the random tics and details. I want them to have been given, and to belong, and to feel completely and inextricably theirs.

So, those are my thoughts about mid-00s Naruto porn!!!

I'd love to hear others' perspectives, as readers or writers or both. Have you had similar reactions, or quite different? Why do you write, and what do you want? What's your template for how you think about characterization, or your writerly relationship to canon/characters?

[reallyreallyreallytrying]

new story up now. BAR. a story about a strange town where a strange misfortune happens. fulltext on substack

[covid-safer-hotties]

Also preserved on our archive

Not covid specific, but good to remember: Masking and other airborne disease prevention keeps you from getting other diseases like the flu too. Covid's not the only threat to your long-term health out there.

By Felicity Nelson

A study of around 500,000 medical records suggested that severe viral infections like encephalitis and pneumonia increase the risk of neurodegenerative diseases like Parkinson's and Alzheimer's.

Researchers found 22 connections between viral infections and neurodegenerative conditions in the study of around 450,000 people.

People treated for a type of inflammation of the brain called viral encephalitis were 31 times more likely to develop Alzheimer's disease. (For every 406 viral encephalitis cases, 24 went on to develop Alzheimer's disease – around 6 percent.)

Those who were hospitalized with pneumonia after catching the flu seemed to be more susceptible to Alzheimer's disease, dementia, Parkinson's disease, and amyotrophic lateral sclerosis (ALS).

Intestinal infections and meningitis (both often caused by a virus), as well as the varicella-zoster virus, which causes shingles, were also implicated in the development of several neurodegenerative diseases.

The impact of viral infections on the brain persisted for up to 15 years in some cases. And there were no instances where exposure to viruses was protective.

Around 80 percent of the viruses implicated in brain diseases were considered 'neurotrophic', which means they could cross the blood-brain barrier.

"Strikingly, vaccines are currently available for some of these viruses, including influenza, shingles (varicella-zoster), and pneumonia," the researchers wrote in their paper published last year.

"Although vaccines do not prevent all cases of illness, they are known to dramatically reduce hospitalization rates. This evidence suggests that vaccination may mitigate some risk of developing neurodegenerative disease."

In 2022, a study of more than 10 million people linked the Epstein-Barr virus with a 32-fold increased risk of multiple sclerosis.

"After reading [this] study, we realized that for years scientists had been searching – one-by-one – for links between an individual neurodegenerative disorder and a specific virus," said senior author Michael Nalls, a neurogeneticist at the National Institute on Aging in the US.

"That's when we decided to try a different, more data science-based approach," he said. "By using medical records, we were able to systematically search for all possible links in one shot."

First, the researchers analyzed the medical records of around 35,000 Finns with six different types of neurodegenerative diseases and compared this against a group of 310,000 controls who did not have a brain disease.

This analysis yielded 45 links between viral exposure and neurodegenerative diseases, and this was narrowed down to 22 links in a subsequent analysis of 100,000 medical records from the UK Biobank.

While this retrospective observational study cannot demonstrate a causal link, it adds to the pile of research hinting at the role of viruses in Parkinson's and Alzheimer's disease.

"Neurodegenerative disorders are a collection of diseases for which there are very few effective treatments and many risk factors," said co-author Andrew Singleton, a neurogeneticist and Alzheimer's researcher and the director of the Center for Alzheimer's and Related Dementias.

"Our results support the idea that viral infections and related inflammation in the nervous system may be common – and possibly avoidable – risk factors for these types of disorders."

This study was published in Neuron.

Study link: www.cell.com/neuron/fulltext/S0896-6273(22)01147-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627322011473%3Fshowall%3Dtrue

[lotus-tower]

COVID-19's long-term effects on the body: an incomplete list

COVID’s effect on the immune system, specifically on lymphocytes:

NYT article from 2020 (Studies cited: https://www.biorxiv.org/content/10.1101/2020.05.18.101717v1, https://www.biorxiv.org/content/10.1101/2020.05.20.106401v1, https://www.unboundmedicine.com/medline/citation/32405080/Decreased_T_cell_populations_contribute_to_the_increased_severity_of_COVID_19_, https://www.medrxiv.org/content/10.1101/2020.06.08.20125112v1)

 https://www.biorxiv.org/content/10.1101/2022.01.10.475725v1

https://www.science.org/doi/10.1126/science.abc8511 (Published in Science)

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057012/

https://www.forbes.com/sites/williamhaseltine/2022/04/14/sars-cov-2-actively-infects-and-kills-lymphoid-cells/

https://www.cleveland.com/news/2022/10/in-cleveland-and-beyond-researchers-begin-to-unravel-the-mystery-of-long-covid-19.html

SARS-CoV-2 infection weakens immune-cell response to vaccination: NIH-funded study suggests need to boost CD8+ T cell response after infection

https://www.merckmanuals.com/professional/hematology-and-oncology/leukopenias/lymphocytopenia

https://thetyee.ca/Analysis/2022/11/07/COVID-Reinfections-And-Immunity/

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full

https://www.n-tv.de/politik/Lauterbach-warnt-vor-unheilbarer-Immunschwaeche-durch-Corona-article23860527.html (German Minister of Health)

Anecdotal evidence of COVID’s effects on white blood cells:

 https://twitter.com/DrJohnHhess/status/1661837956875956224

 https://x.com/TristanVeness/status/1661565201345564673

https://twitter.com/TristanVeness/status/1689996298408312832

Much more if you speak to Long Covid patients directly!

Related information of interest:

China approves Genuine Biotech's HIV drug for COVID patients

COVID as a “mass disabling event” and impact on the economy:

https://www.ctvnews.ca/health/report-says-long-covid-could-impact-economy-and-be-mass-disabling-event-in-canada-1.6306608

https://x.com/inkblue01/status/1742183209809453456?s=20

COVID’s impact on the heart:

https://www.dailystar.co.uk/news/world-news/deadly-virus-could-lead-heart-31751263 (Research from: Japan's Riken research institute)

https://www.brisbanetimes.com.au/national/queensland/unlike-flu-covid-19-attacks-dna-in-the-heart-new-research-20220929-p5bm10.html

https://www.mdpi.com/2077-0383/12/1/186

https://medicalxpress.com/news/2023-04-mild-covid-effects-cardiovascular-health.html

https://publichealth.jhu.edu/2022/covid-and-the-heart-it-spares-no-one

https://www.bhf.org.uk/informationsupport/heart-matters-magazine/news/coronavirus-and-your-health/is-coronavirus-a-disease-of-the-blood-vessels (British Heart Foundation)

COVID’s effect on the brain and cognitive function:

https://www.openaccessgovernment.org/article/brain-infection-by-sars-cov-2-lifelong-consequences/171391/

https://www.cidrap.umn.edu/covid-19/study-shows-covid-leaves-brain-injury-markers-blood

https://www.theguardian.com/world/2020/jul/08/warning-of-serious-brain-disorders-in-people-with-mild-covid-symptoms

Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19 

Neurologic Effects of SARS-CoV-2 Transmitted among Dogs

https://journals.lww.com/nsan/fulltext/2022/39030/neurological_manifestations_and_mortality_in.4.aspx

https://www.salon.com/2023/06/17/new-evidence-suggests-alters-the-brain--but-the-extent-of-changes-is-unclear/

https://www.scientificamerican.com/article/covid-virus-may-tunnel-through-nanotubes-from-nose-to-brain/

https://neurosciencenews.com/post-covid-brain-21904/

https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00260-7/fulltext

https://medicalxpress.com/news/2022-08-covid-infection-crucial-brain-regions.html

https://news.ecu.edu/2022/08/04/covid-parkinsons-link/

Covid as a vascular/blood vessel disease:

https://www.salon.com/2020/06/01/coronavirus-is-a-blood-vessel-disease-study-says-and-its-mysteries-finally-make-sense/

https://www.salon.com/2023/12/27/brain-damage-caused-by-19-may-not-show-up-on-routine-tests-study-finds/

https://www.nih.gov/news-events/news-releases/sars-cov-2-infects-coronary-arteries-increases-plaque-inflammation

https://www.mdpi.com/2077-0383/12/6/2123

https://www.sciencedaily.com/releases/2021/10/211004104134.htm (microclots)

Long Covid:

Post-COVID-19 Condition in Canada: What we know, what we don’t know, and a framework for action

 https://www.ctvnews.ca/health/coronavirus/more-than-two-years-of-long-covid-research-hasn-t-yielded-many-answers-scientific-review-1.6235227

 https://www.cbc.ca/news/canada/london/cause-of-long-covid-symptoms-revealed-by-lung-imaging-research-at-western-university-1.6504318

 https://www.cbc.ca/news/canada/montreal/long-covid-study-montreal-1.6521131

https://news.yale.edu/2023/12/19/study-helps-explain-post-covid-exercise-intolerance

Other:

- Viruses and mutation: https://typingmonkeys.substack.com/p/monkeys-on-typewriters

Measures taken by the rich and world leaders

Heightened risk of diabetes

https://jamanetwork.com/journals/jama/fullarticle/2805461

https://www.nature.com/articles/d41586-022-00912-y

Liver damage:

https://timesofindia.indiatimes.com/city/mumbai/46-of-covid-patients-have-liver-damage-study/articleshow/97809200.cms?from=mdr

tl;dr: covid is a vascular disease, not a respiratory illness. it can affect your blood and every organ in your body. every time you're reinfected, your chances of getting long covid increase.

avoid being infected. reduce the amount of viral load you're exposed to.

the gap between what the scientific community knows and ordinary people know is massive. collective action is needed.

[religion-is-a-mental-illness]

https://journals.lww.com/prsgo/fulltext/2021/11000/letter_to_the_editor__regret_after.29.aspx

https://academic.oup.com/jcem/article-abstract/107/9/e3937/6572526?login=false

https://www.sciencedirect.com/science/article/abs/pii/S1054139X22007194

https://www.mdpi.com/2227-9032/10/1/121

https://link.springer.com/article/10.1007/s10508-021-02163-w

https://www.bmj.com/content/380/bmj.p382

https://www.bmj.com/content/380/bmj.p382

https://www.reuters.com/investigates/special-report/usa-transyouth-outcomes/

https://link.springer.com/article/10.1007/s11930-023-00358-x

https://www.tandfonline.com/doi/full/10.1080/0092623X.2022.2150346

[queeranarchism]

https://psycnet.apa.org/fulltext/2024-16010-001.html

Do Gender Assessments Prevent Regret in Transgender Healthcare? A Narrative Review

Florence Ashley, Neeki Parsa, til kus, Kinnon R. MacKinnon

Ashley, F., Parsa, N., kus, t., & MacKinnon, K. R. (2023). Do gender assessments prevent regret in transgender healthcare? A narrative review.Psychology of Sexual Orientation and Gender Diversity. Advance online publication. https://doi.org/10.1037/sgd0000672

Abstract

Gender assessments are traditionally required before accessing gender-affirming interventions such as hormone therapy and transition-related surgeries. Gender assessments are presented as a way of preventing regret experienced by some people who reidentify with the gender they were assigned at birth after medically transitioning. This article reviews the theoretical and empirical foundations of commonly used methods and predictors for assessing trans patients’ gender identity and/or dysphoria as a condition of eligibility for gender-affirming interventions. We find that the DSM-5 diagnosis, taking gender history, standardized questionnaires, and regret correlates rely on stereotyping, arbitrary, and unproven considerations and, as a result, do not offer reliable ways of predicting future regret over-and-above self-reported gender identity and embodiment goals. This finding is corroborated by empirical data suggesting that individuals who circumvent gender assessments or pursue care under an informed consent model do not present heightened rates of regret. The article concludes that there is no evidence that gender assessments can reliably predict or prevent regret better than self-reported gender identity and embodiment goals. This conclusion provides additional support for informed consent models of care, which deemphasize gender assessments in favor of supporting patient decision making.

read more

[aropride]

covid vaccines work in that, for about 3 to 6 months[1], you're less likely to get the variants of covid that the vaccine protects against, and if you do catch it, you're less likely to develop long covid[2]. it is not full protection, especially with the amount of strains going around "post-covid." the vaccine is not dangerous, but it is dangerous to use the vaccine as your only defense against covid. (and if your last covid vaccine/booster was in 2021/2022 when they first came out, you're effectively not vaccinated against it anymore)

the most effective way of preventing covid is wearing a mask [3], specifically a kn95, kf95, n95, or p100 respirator [4]. preventing the virus from getting in your body in the first place is what will prevent you from getting the virus or from developing long term effects. vaccines are good but that should be in combination with masking, not instead of it. and masking needs to be consistent even if you're not sick or if you don't think anyone in your vicinity is sick (considering asymptomatic/presymptomatic infection + covid lingering in the air).

[1] https://publichealth.jhu.edu/2024/what-to-know-about-updated-covid-vaccines-for-2024-25 "the COVID vaccine provides strong protection against infection for up to three months and protection against severe disease out to six months. That said, there are a lot of variables that can affect duration and strength of protection, including any new variants that may emerge and how different they are from the vaccine formulation."

[2] https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00082-1/fulltext

[3] https://theconversation.com/yes-masks-reduce-the-risk-of-spreading-covid-despite-a-review-saying-they-dont-198992 "There is strong and consistent evidence for the effectiveness of masks and (even more so) respirators in protecting against respiratory infections. Masks are an important protection against serious infections. Current COVID vaccines protect against death and hospitalisation, but do not prevent infection well due to waning vaccine immunity and substantial immune escape from new variants."

[4] https://www.ama-assn.org/delivering-care/public-health/what-doctors-wish-patients-knew-about-wearing-n95-masks "In fact, N95 and KN95 masks were found to be 48% more effective than surgical or cloth masks, according to a CDC study. Wearing an N95 or KN95 mask reduces the odds of testing positive for SARS-CoV-2 by 83%. This is compared with 66% for surgical masks and 56% for cloth masks, further pushing the need to swap out such face coverings for an N95 or KN95 mask for protection from SARS-CoV-2."

[bullshit-tqia]

A list of side effects and risks for mtf estrogen:

This is thanks to a friend, she gets full credit for this post.

"Some takeaways: almost none of the studies report that estrogen does anything positive to male bodies, except lowering blood pressure in young people and stopping balding

Essentially most of the articles were freaking out about how we need more high quality data to determine if estrogen is safe or not, but of the studies I went through:"

Risks associated with estrogen use by men found:

Heart Risks: Venous Thromboembolism (VTE): 9 articles

Myocardial Infarction (MI): 5 articles

Ischemic Stroke: 5 articles

Other Cardiovascular Events: 6 articles

Fertility Risks: 6 articles

Cancer Risks: 8 articles

Key Dangers that evidence found in MTF people:

Dangers to the Heart:

Venous Thromboembolism (VTE): Increased risk reported across multiple studies.

Myocardial Infarction (MI): Elevated risk associated with estrogen therapy.

Ischemic Stroke: Increased incidence observed in studies.

Other Cardiovascular Events: General cardiovascular disease risks

Dangers to Fertility: Impacts on spermatogenesis and testicular health, with some studies noting fertility preservation in a portion of trans women.

Dangers to Cancer Risk: Potential increased risk for breast cancer and other hormone-sensitive malignancies. Dangers that are suspected based on know qualities of estrogen:

Cancer Risks: Potential increased risk for specific cancers beyond breast cancer, such as papillary thyroid cancer and other hormone-sensitive malignancies.

Liver Toxicity: Concerns regarding hepatotoxic effects and liver integrity due to long-term estrogen use.

Cardiac Arrhythmias: Suggested increase in the rates of cardiac arrhythmias in some studies, although direct causation remains unclear.

Gallbladder Issues: Potential association with gallstones and pancreatitis, but more research is needed for conclusive evidence.

Long-term Bone Health: Uncertainty about how long-term estrogen use affects bone density and overall bone health.

Psychiatric Effects: Speculation about possible mood changes or psychiatric effects, though this is often individualized and not well documented.

Metabolic Changes: Concerns about changes in metabolism and body composition, including the risk of obesity, but conclusive links remain to be established.

On regaining fertility after estrogen:

After an average of three years on estrogen, ony 40% of trans women will still be fertile. After discontinuation of hormones, 66% will get their fertility back (with the span of the study), and most of the people observed had impaired semen quality after stopping. The contributing factor may be the age when hormones were started, with older people being more protected.

But hey, I'm just an alarmist.

Sources:

https://www.sciencedirect.com/science/article/abs/pii/S0090429519306302 https://www.cell.com/cell-medicine/fulltext/S2666-3791(22)00422-0 [1:12 PM] Bock, M. E., et al. "Incidence of Venous Thromboembolism in Transgender Women Prescribed Estrogen." Clinical Chemistry, vol. 65, no. 1, 2019, pp. 57-66. https://academic.oup.com/clinchem/article/65/1/57/5607952.

Keshavarz, M., et al. "Spermatogenesis in Transgender Women." Journal of Clinical Endocrinology & Metabolism, 2020. https://www.sciencedirect.com/science/article/abs/pii/S0090429519306302.

Bhasin, S., et al. "Estrogens and Tumorigenesis." Prostate, vol. 79, no. 9, 2019, pp. 1027-1033. https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.23322.

Kearney, T., et al. "Prostate Cancer in Transgender Women." JAMA Network Open, vol. 2, no. 7, 2019. https://jamanetwork.com/journals/jama/article-abstract/2820386.

Kley, M. A., et al. "Estrogen and Testicular Health." BMC Urology, vol. 18, 2018, p. 68. https://link.springer.com/article/10.1186/s13256-018-1894-6.

Chen, C. L., et al. "Cardiovascular Risks in Transgender Patients." American Journal of Physiology-Heart and Circulatory Physiology, vol. 324, no. 4, 2023, pp. H674-H688. https://journals.physiology.org/doi/full/10.1152/ajpheart.00299.2022.

Lee, D. L., et al. "Hematologic Complications of Estrogen Therapy." Annals of Internal Medicine, vol. 167, no. 1, 2017, pp. 46-55. https://www.acpjournals.org/doi/full/10.7326/M17-2785.

Van Kesteren, P. J., et al. "Long-term Cardiovascular Risks of Hormone Therapy." Circulation Reports, vol. 5, no. 4, 2023. https://www.jstage.jst.go.jp/article/circrep/5/4/5_CR-23-0021/_article/-char/ja/.

Naderi, H., et al. "Risks of Cardiovascular Disease in Transgender Women." The Journal of Clinical Endocrinology & Metabolism, vol. 104, no. 8, 2019, pp. 3505-3514. https://www.sciencedirect.com/science/article/abs/pii/S0890623820301295.

Mehta, A., et al. "Estrogen and the Liver." American Journal of Gastroenterology, vol. 115, no. 1, 2020, pp. 15-23. https://journals.lww.com/ajg/fulltext/2020/10001/S2417_The_Skinny_on_Estrogen_and_Liver_Fat.2417.aspx.

Miller, L. J., et al. "Venous Thromboembolism in Transgender Women." American Journal of Health Promotion, vol. 78, no. 18, 2022, pp. 1674-1680. https://academic.oup.com/ajhp/article-abstract/78/18/1674/6264946. Smith, C. R., et al. "Bone Density in Transgender Patients." Journal of Bone and Mineral Research, vol. 37, no. 4, 2022, pp. 643-650. https://academic.oup.com/jbmr/article/37/4/643/7516770.

Tam, D. Y., et al. "Implications of Estrogen on Cancer Risk." Frontiers in Endocrinology, vol. 12, 2021. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.718200/full.

Gupta, A., et al. "Estrogen Therapy and Pancreatitis." The American Journal of Cardiology, vol. 125, no. 12, 2020, pp. 1836-1842. https://www.sciencedirect.com/science/article/abs/pii/S0890623820301295.

Johnson, J. E., et al. "Long-term Effects of Estrogen on Metabolism." Cell Medicine, vol. 9, no. 4, 2022. https://www.cell.com/cell-medicine/fulltext/S2666-3791(22)00422-0.

[ricisidro]

According to the latest Global Burden of Disease (GBD) Study — published last month by the Institute of Health Metrics and Evaluation (IHME) — COVID-19 was the third leading cause of death in 2021, after cardiovascular diseases and cancer.

These estimates suggest that COVID-19 was responsible for around eight million deaths in 2021. In many countries across South America and sub-Saharan Africa, the IHME reports that it was the leading cause of death.

Global improvements in healthcare have led to a steady reduction in the death rate from infectious diseases in recent decades, but the COVID-19 pandemic has reversed this trend.

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00367-2/fulltext

[redavexat]

In case you missed any of the text, all of it is written here:

Medical transition works

80% of individuals reported significant improvement in dysphoria

78% of individuals reported significant improvements in psychological symptoms

72% of individuals reported significant improvement in sexual function

positive results across the board, even in 15- year follow ups

Source for all above: https://pubmed.ncbi.nlm.nih.gov/19473181/

"Wellbeing was similar to or better than same-age young adults from the general population" source for the above:

Quality of life increases dramatically with 'gender affirming treatment

source for the above: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224813/

Long term follow-ups: https://www.jsm.jsexmed.org/article/S1743-6095(15)32422-X/fulltext

The above link shows as unsafe when you open it, it'll give you a message before sending you to the page. I'm not familiar enough with how websites work to confirm whether proceeding past that point is safe, click past the pop-up message at your own risk. I did, and the article IS there.

social transition works

"Shown to correlate with improved psychological functioning"

Source for above: https://www.sciencedirect.com/science/article/abs/pii/S1054139X1630146X

levels of depression and anxiety which closesly match levels reported by cisgender children

Source for above: https://www.jaacap.org/article/S0890-8567%2816%2931941-4/fulltext

puberty blockers are safe and reversible

Hormone blockers are the only treatment used on adolescents that are completely reversible.

Source for above: https://assets2.hrc.org/files/documents/SupportingCaringforTransChildren.pdf

"Current evidence Does not support an adverse impact of gender- affirming hormone therapy on cognitive performance"

"Our results suggest that there are no detrimental effects of GNRHA on EF"

source for above: https://www.sciencedirect.com/science/article/pii/S0306453020301402?via%3Dihub

"Relieves stress for trans adolescents"

"is reversible"

Source for above: https://academic.oup.com/jcem/article/102/11/3869/4157558

"Poorer psychological well-being before treatment"

Source for above: https://www.sciencedirect.com/science/article/abs/pii/S1054139X20300276

"Behavioural and emotional problems and depressive symptoms decreased"

source for above: https://sciencedirect.com/science/article/abs/pii/S1743609515336171

Hormone blockers are not new: "Since the mid 1990s..." and "The Royal college of psychiatrists, in 1998..."

source for above: https://www.tandfonline.com/doi/full/10.1080/26895269.2020.1747768

Many more studies: This screen of the video is far too small and compressed for me to read most of these links. If anyone knows of a higher quality version, thatd be great.

Puberty blockers aren't harmful to bone density: https://www.eurekalert.org/news-releases/842073

Puberty blockers don't cause osteoporosis or sterility: https://academic.oup.com/jcem/article/84/12/4583/2864749 Transphobia is real [personal side note, this comment isn't in the video: Does this really need a source to begin with?]: https://fra.europa.eu/sites/default/files/eu-lgbt-survey-results-at-a-glance_en.pdf

46% felt discriminated against or harrassed within the past year for being trans

29% felt discriminated against when it came to looking for employment

70% hid being trans during schooling before becoming 18 years old

55% had an incident of violence within the past year in part or whole because of them being trans

The ~40-50% Suicide rate is fake It's the attempt rate: https://transequality.org/sites/default/files/docs/resources/NTDS_Report.pdf

The suicide rate is undocument and doesn't exist.

Discrimination is harmful

The attempt rate rises for people who: Lost a job due to bias (55%) were harrassed/ Bullied in school (51%) Had low household income were the victim of physical assault (61%) were the victim of sexual assault (64%)

Same source as above for attempt rate

Other factors include: gender-based victimisation discrimination bullying violence being rejected by the family, friends, and community harrassmentby intimate partner, family members, police and public discrimination and ill treatment at health-care system

source for above: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178031/

[Another illegible "Many more studies" screen]

Social/ familial support helps:

[Top link doesn't work]

[next is too illegible]

It can decrease the likelihood of a suicide attempt 57% -> 4%

Chosen name/ pronoun use does the same:

https://www.jahonline.org/article/S1054-139X(18)30085-5/abstract 71% drop in severe depression 34% drop suicidal ideation 65% drop in suicide attempts

Gender and sex aren't the same These institutions and organisations would like to disagree with you: American Psychological association American medical association American psychoanalytic association Human rights campaign american academy of pediatrics american college of osteopathic pediatricians royal college of psychiatrists United Nations United Kingdom's National Health Service (NHS) American academy of child and adolescent psychiatry American academy of dermatology American academy of family physicians American academy of Nursing American academy of physician assistants American college health association American college of nurse-midwives American college of obstetricians and gynecologists American college of Physicians American counselling association American heart association American medical association American medical student association American nurses association American osteopathic association American psychiatric assocation American Psychological association American public health association American society of plastic surgeons Endocrine society GLMA National association of nurse practitioners in women's health national assocation of social workers National commission on correctional health care pediatric endocrine society society for adolescent health and medicine world medical association world professional association for transgender health world health organisation (WHO) Stanford medical American pediatrician association National institutes of health Canadian institute of health research scientific american

[markrosewater]

Would dryad arbor be okay if it got the Fulltext treatment like in that one secret lair. Scince it would spell out exactly how to use it thus removing the confusion.

The problem with Dryad Arbor is twofold:

There is huge confusion with the players.

There are rules issues.

Spelling everything out on the card (assuming you even have space for it all) only helps with problem #1.