#FGF21

[anabananawl]

I’ve lost the will to care about my health- here’s a list of things I’m doing to lose weight in 2024 (with pros and cons from research and person experience):

1. Caffeine (Long Black, and if you need laxative and are lactose intolerant: milk but no sugar). Caffeine is know for its stimulation on the nervous system. It sends direct signals to fat cells and breaks it down. Drinking with added syrups or sugars may cause you to gain weight. But, it does taste better with it. It can raise blood pressure, and therefore you need to consider pre-existing conditions. For example: I have POTS, and I’m not supposed to drink large amounts of caffeine or do too much strenuous activity, but I don’t drink it every day.

2. Cold compresses on areas you want to lose fat. Shivering is known to help induce weight loss- as it releases the hormone irisin from muscles and the hormone FGF21 from brown fat stores. It also can increase metabolism as it increases oxidation of both fat and carbohydrates. I usually add wearing loose clothing or shorts and turn on the aircon. Swimming in cold water may help too!! But, obviously don’t do it too much in one go as you may be prone to hypothermia or other conditions like colds.

3. Walking and online workouts. Like I said before, I can’t do too much strenuous activity as it makes me faint or puts my heart rate at an uncomfortable level- but, walking a lot helps me since it doesn’t need to be too hard. You can find online workouts that help target areas of unwanted fat (and you can usually do it from your bed)! It can be uncomfortable, so don’t overwork yourself.

4. N1cot1n3 products. I’m not promoting this to younger audiences (or any audience really)- but, it’s not my business on your age and what you do. This substance helps reduce appetite and therefore food intake. It is also said to increase resting metabolic rate and number of calories the body burns at rest. However, it isn’t good for your lungs, gums, or any other body parts. And, most products within this substance range have a small amount of calories themselves. Some people find that it clears up their skin, others find it doesn’t, and so on, so forth. However, OD is possible, especially in the beginning (throwing up, fainting, and other horrible things), but once I got over that, it’s been amazing (but very addictive).

5. Of course, the most well known way to lose weight is indulging in a calorie deficit. This can get to the point of being severe and would be bad for you (as you probably know)- and unless ending up in the hospital from not eating enough is on your 2024 bucket list, you have to do this in moderation (not super fun, I can tell you that). You can find inspiration pics on Tumblr, TikTok or Pinterest for calorie deficit diets (and I’m more than happy to post some on here as well), but use this one safely if you can. Or hide your symptoms if able- that is a personal choice.

6. This one goes hand in hand with 5. but, cutting out unnecessary fat, salt and sugar. Again, you can find inspiration for these types of meals online, but do it safely. Don’t do what Emily did on Devil Wears Prada, and only eat a cube of cheese when feeling faint- that may actually have you in the hospital being force fed. Following diet and healthy lifestyle videos (some are toxic, so beware) may help with motivation. I’m happy to try and find some for you and put it in comments. But, doing this can also help with skin, hair, and overall health. If you’ve seen people online who go a week without unnecessary sugar, you know what I’m talking about.

7. Okay, this one may be controversial (more than the others), but go off weight gaining medication. Of course, some people physically cannot go off those medications, and that’s okay- but if you have the choice, then go for it. Talk to a G.P about your concerns, and hopefully they can help you out. Again, this may be difficult, but it doesn’t hurt to try. I have been put on multiple medications in the past that made me gain mass amounts of weight, and they told me to just go on a diet and exercise (which of course didn’t work because the medication was so strong). I’m lucky enough to be at an age (no longer considered to be under “Gillick competence” in the medical world) and position in my life where I have the freedom to refuse those medications, but I understand that you may not. I’m not saying you should go off those medications without guidance, but I found that at one point, it was my only option as it had other side effects that threatened my life (and G.P wouldn’t let me go off).

All of these may be hard to accomplish due to money, living, and age restrictions. Practicing self control, and being more assertive (if able) with others can make a big difference. Of course, some families may not allow this, maybe due to cultural (or other) reasons, but as long as you’re safe (I don’t have much concern for myself anymore, but that’s personal preference), and able to live without a hospital. If you have other ideas, then let me know, but this is personal preference and what I found helps me. Good luck on your journey! You’re beautiful/handsome, and I wish you the very best.

[regenerationcenterthailand]

A compound called FGF21, produced by tumors, suppresses the immune system by altering the cholesterol processing in specific immune cells known as CD8+ T cells.

[jhavelikes]

The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine system that governs multiple metabolic processes in mammals. FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the βKlotho–FGFR4 complex in hepatocytes to promote metabolic responses to feeding. By contrast, under fasting conditions, the liver secretes the starvation hormone FGF21, which induces metabolic responses to fasting and stress responses through the activation of the hypothalamus–pituitary–adrenal axis and the sympathetic nervous system following binding to the βKlotho–FGFR1c complex in adipocytes and the suprachiasmatic nucleus, respectively. Finally, FGF23 is secreted by osteocytes in response to phosphate intake and binds to αKlotho–FGFR complexes, which are expressed most abundantly in renal tubules, to regulate mineral metabolism. Growing evidence suggests that the FGF–Klotho endocrine system also has a crucial role in the pathophysiology of ageing-related disorders, including diabetes, cancer, arteriosclerosis and chronic kidney disease. Therefore, targeting the FGF–Klotho endocrine axes might have therapeutic benefit in multiple systems; investigation of the crystal structures of FGF–Klotho–FGFR complexes is paving the way for the development of drugs that can regulate these axes.

The Klotho proteins in health and disease | Nature Reviews Nephrology

[biotech-news-feed]

DATA BYTE HOW 89 BIO’S PHASE IIB NASH DATA MATCH UP WITH AKERO’S IN FGF21 CLASSBY Planned Phase III trials would clarify benefit compared with other classes ahead in regulatory queue #BioTech #science

[sauolasa]

Smaltire i postumi di una sbornia? Grazie all'iniezione di ormoni nei topi "ubriachi"

L'ormone, che si chiama FGF21, attira da anni l'attenzione degli scienziati: è prodotto dal fegato e svolge un ruolo significativo nell'aiutare - sia gli esseri umani che i topi - a processare determinati alimenti, come l'alcol, limitandone i tempi dell'effetto. Una ricerca della Texas University

[leontiucmarius]

Injecția cu hormoni care „vindecă” beția

Într-un nou studiu, cercetătorii au creat injecția cu hormoni care „vindecă” beția, care acționează asupra părții din creier ce controlează vigilența. Un hormon numit factor de creștere a fibroblastelor 21 (FGF21) protejează reflexul de redresare […] Articolul Injecția cu hormoni care „vindecă” beția apare prima dată în Descopera. Această știre a fost preluată de pe portalul amintit Această…

[myfeeds]

Drunk mice sober up after a hormone shot

“We’ve discovered that the liver is not only involved in metabolizing alcohol but that it also sends a hormonal signal to the brain to protect against the harmful effects of intoxication, including both loss of consciousness and coordination,” says co-senior study author Steven Kliewer of the University of Texas Southwestern Medical Center. “We’ve further shown that by increasing FGF21 concentrations even higher by injection, we can dramatically accelerate recovery from intoxication. FGF21 does this by activating a very specific part of the brain that controls alertness,” says Kliewer. The consumption of ethanol produced by the natural fermentation of simple sugars in ripening fruits and nectars can cause intoxication, impairing mobility and judgement. Animals that consume fructose and other simple sugars have evolved liver enzymes to break down ethanol. FGF21 is a hormone that is induced in the liver by a variety of metabolic stresses, including starvation, protein deficiency, simple sugars, and ethanol. In humans, ethanol is by far the most potent inducer of FGF21 described to date. Previous studies showed that FGF21 suppresses ethanol preference, induces water drinking to prevent dehydration, and protects against alcohol-induced liver injury. In the new study, Kliewer and co-senior study author David Mangelsdorf of the University of Texas Southwestern Medical Center show that FGF21 plays a broader role in defending against the harmful consequences of ethanol exposure than previously thought. In mice, FGF21 stimulated arousal from intoxication without changing the breakdown of ethanol. Mice lacking FGF21 took longer than their littermates to recover their righting reflex and balance following ethanol exposure. Conversely, pharmacologic FGF21 administration reduced the time needed for mice to recover from ethanol-induced unconsciousness and lack of muscle coordination. Surprisingly, FGF21 did not counteract sedation caused by ketamine, diazepam, or pentobarbital, indicating specificity for ethanol. FGF21 mediated its anti-intoxicant effects by directly activating noradrenergic neurons in the locus coeruleus region in the brain, which regulates arousal and alertness. Taken together, the results suggest that the FGF21 liver-brain pathway evolved to protect against ethanol-induced intoxication. According to the authors, this pathway may modulate a variety of cognitive and emotional functions to enhance survival under stressful conditions. Yet it remains to be determined whether activation of the noradrenergic system contributes to FGF21’s other effects, including those on metabolism and ethanol and sweet preference. Although both FGF21 and noradrenergic nervous system activity are induced by ethanol in humans, additional studies will also be required to determine whether FGF21’s anti-intoxicant activity translates to humans. “Our studies reveal that the brain is the major site of action for FGF21’s effects,” Mangelsdorf says. “We are now exploring in greater depth the neuronal pathways by which FGF21 exerts its sobering effect.”

[dailytechnologynews]

Hormone treatment makes alcoholic monkeys drink 50% less. A hormone produced by the liver called fibroblast growth factor 21 (FGF21) makes alcohol-addicted vervet monkeys cut their drinking by half, according to international scientists. https://ift.tt/2qWuXVyQU

[neurosciencenews]

Brain Cells that Trigger Sugar Cravings and Consumption Identified

FGF21, a hormone created in the liver in response to increased levels of sugar, acts in the brain to suppress sugar intake and controls the preference for sweet-tasting foods.

[new25kidney]

The Extreme Kidney Disease Solution Book Pdf file Shelly Manning

Students increased issues related to the opportunity affect on their expert career because of the unexpected timetable adjustments. FGFs are signaling healthy proteins that manage embryonic improvement, tissue regeneration, also as diverse metabolic features by binding extracellularly to 4 cell area tyrosine kinase FGF receptors (FGFRs 1-4) . FGF21 is mostly secreted inside the liver and exerts its many helpful metabolic effects by binding to FGFRs from the reputation of coreceptor ß-Klotho . By virtue of such components, FGF21 administration has improved experimental NASH and also CKD . The clinical development of FGF21, however, is hampered by its simple fifty percent-daily life (.5-5 h) and by tissue FGF21 amount of resistance, which is subtended by FGFR1 and in addition ß-Klotho downregulation as well as is get over by pharmacological dosages of FGF21. The capability for gut microbiota to have got discussion with hold metabolic and defense reactions as well as to play a function in the creation of weight problems-related issues continues to be more and more identified . Sufferers with NAFLD as well as CKD show an altered gut microbiota structure, by using a general decrease in healthful Bacteroidetes, Lactobacillaceae, as well as Prevotellaceae households and also interference of your common intestinal shield .

With absence of kidney work, it includes an deposition normal water, spend, also as harmful materials within the complete body that happen to become usually excreted from the kidney. Loss in kidney function also causes other problems like anemia, higher bloodstream stress degree, acidosis , problems of cholestrerol levels and also essential essential fatty acids, and also bone disease. If you have vital severe kidney disease however have not even created kidney failing, confer with your physician about that kind of dialysis might be absolute best for you. If you have serious kidney disease that moves along, you might possess the choice of the kidney transplant. Several experts acknowledge that it is the most effective option for people with kidney failure. Generally talking, individuals which may have kidney transplants stay a lot more than people dealt with with dialysis. Most people which have extended kidney disease have issues with really higher blood pressure at several time during their disease.

Regardless Of If The Kidney Disease Solution Amazon . com Is Accessible ?

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[michelvoss]

carbohydrate gen RARB.

…”two novel loci; a common variant in RARB locus for carbohydrate intake and a rare variant in DRAM1 locus for protein intake, and corroborating earlier FGF21 and FTO findings.” Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Jordi Merino, Hassan S. Dashti, […]Toshiko…

[kamuoyuhaber-blog]

Keşfedilen yeni gen vücuttaki yağ oranını azaltıyor

Keşfedilen yeni gen vücuttaki yağ oranını azaltıyor

Yediklerimizin oranı her zaman bilinçli seçimlere bağlı olarak kendini göstermez. Bu bazen genetik faktörlere bağlı olarak değişiklik gösterir.

FG21 GENİ KARBONHİDRAT VE LİPİT ALIMINI ETKİLİYOR

Özellikle de FG21 olarak adlandırılan bir genin karbonhidrat ve lipit (yağ) alımını da etkilediği tespit edildi.

YAĞ ORANINDA AZALMA MEYDANA GELİYOR

Exeter…

[stupendousunknownstrawberry]

Za słabość do słodyczy odpowiada wątroba

Za słabość do słodyczy odpowiada wątroba

Osoby posiadające określony wariant genu sterującego wydzielaniem hormonu FGF21 w wątrobie mają większą skłonność do sięgania po słodkie przekąski – czytamy na łamach “Cell Metabolism”.

[askdurianrider]

Unlimited carbs can make you fat. I don’t eat any overts, train a decent amount, and have been low fat vegan for 6 years. But I started medicating with marijuana and bc of that i’ve had the munchies every day the last 4 weeks and over eat on rice, sugar, cereal etc. I’ve GAINED 10 lbs in 4 weeks already. not changing anything else.

lol DRUGS ruin your FGF21 levels bro so don’t blame healthy eating and lifestyle! BLAME YOUR DRUG ADDICTION!

I eat unlimited carbs. I train LESS than you. Im double your age almost and Im fucking RAZOR LEAN bruh.

[durianriderofficial]

How can someone like Texas fruitarian who lives on fruit still have a fukd up thyroid according to blood tests and high cholesterol?

She must have done some real damage in the past.

Her FGF21 system must be right screwed up. If she was my gf though she would get skinny AF.

[nahaslegal]

3dlabprint p38

The confirmed presence of UCP1 + brown fat in humans has added to the interest in finding methods and molecules that can augment energy expenditure through browning of beige fat cells ( 5– 7). Several polypeptides, including FGF21, BMP7/8b, BNP/ANP, and orexin, all have interesting browning effects ( 8– 12). Irisin was of interest because it is induced during exercise in rodents and is at least partially responsible for the browning response observed in white fat during chronic exercise ( 2). The parent polypeptide, FNDC5, is synthesized as a type 1 membrane protein and is then cleaved and shed into the circulation as a highly glycosylated polypeptide of roughly 12kDa. Irisin appears to act preferentially on the browning of white fat deposits when elevated in the blood of obese mice via viral vectors. This correlates with improvements in glucose tolerance in obese mice. Regarding human irisin, it is clear that FNDC5 mRNA is increased in skeletal muscle in some exercise paradigms but not others ( 2, 13, 14). Interestingly, two articles report that human patients with diabetes are deficient in irisin compared with normal counterparts ( 15, 16). Because the human irisin mRNA has an AUA start codon in the precise location where other species have a classical ATG start codon, the possibility that the human gene might not encode a protein has been raised ( 17), though the large number of studies measuring human irisin in blood with different antibodies and methods would seem to close this issue ( 15, 16, 18– 22). ( 23) addressed the signal transduction pathways by which irisin drives the browning of white fat cells. This article used the mammalian irisin produced in yeast cells and found that it is both heavily glycosylated and biologically active when placed on either 3T3-L1 cells or primary cultures from the rat inguinal depot. The effects on the 3T3-L1 cultures are especially impressive because these cells are generally viewed as very “white,” or not prone to the induction of mRNA encoding UCP1 and other thermogenic genes. The article shows rather convincingly that these browning effects depend on the activation of extracellular signal–related kinase (ERK) and p38 protein kinase signaling cascades. While both of these kinases have been implicated previously in the thermogenic actions of other agents on brown fat, including β-adrenergic agonists and FGF21, the role in irisin action was not known ( 11, 24, 25). The signal transduction through ERK and p38 occurs within 20 min after irisin is added to the cell culture. The swift response and the evidence that irisin directly binds to the cell membrane alludes to a yet-to-be-identified irisin receptor present in both primary inguinal cells and 3T3-L1 cells. Further studies will illustrate how the expression and activation of this receptor is regulated under physiological (exercise) and/or pathological (metabolic diseases) conditions. further demonstrate that mutation of either glycosylation site of irisin compromised its activity whether this is due to a strict requirement of these modifications for (putative) receptor binding or whether they influence protein folding/solubility was not addressed.The p38MAPK family of Mitogen Activated Protein Kinases are a group of signalling molecules involved in cell growth, survival, proliferation and differentiation. The widely studied p38α isoform is ubiquitously expressed and is implicated in a number of cancer pathologies, as are p38γ and p38δ. However, the mechanistic role of the isoform, p38β, remains fairly elusive. Recent studies suggest a possible role of p38β in both breast and endometrial cancer with research suggesting involvement in bone metastasis and cancer cell survival. Female tissue specific cancers such as breast, endometrial, uterine and ovary account for over 3,000,000 cancer related incidents annually advancements in therapeutics and treatment however require a deeper understanding of the molecular aetiology associated with these diseases.