#Dr. Oanh Nguyen

[intelligentliving]

Australian scientists at the Peter Doherty Institute for Infection and Immunity mapped how the body’s immune system responds to coronavirus. The study involved four spaced out sessions of blood sample testing. The blood came from an otherwise healthy 47-year-old woman who tested positive with COVID-19 and had mild-to-moderate symptoms. This...

[marwahstudios]

Sandeep Marwah Knows His Job as Global Cultural Ambassador- ASEAN Group

Noida: Thirty ladies representing eight ASEAN countries and members of ASEAN Ladies Circle honoured Sandeep Marwah President of Marwah Studios for his untiring contribution to  international media and entertainment industry during their full day seminar cum workshop at Noida Film City.

“Forty years in media, thirty years in studio business, more than twenty five years in film, TV and media education, Dr. Sandeep Marwah is a  legend. We feel honoured in honouring him today in the presence of International personalities and diplomats from various countries. Dr. Marwah in real is an Ambassador of art and culture not only representing India but many other countries,” said H.E. Pham Sanh Chau Ambassador of Vietnam to India while presenting the certificate to Marwah.

The event was witnessed by Datin Mariaratnah Binti Hj Apong Spouse of Head of Mission of Brunei, Nadiah Ahmad Rafie, Norzainah Hj Ramlee and Nur Amani Yahya from Embassy of Brunei attended the seminar.

Katmany Chouanghom Spouse of Head of Mission of Laos, Pranom Boupha, Daovone Saritthirath and Soudalath Inthavong from Embassy of Laos were there. Datin Rozita Spouse of Head of Mission of Malaysia, Termeeta Kaur Banwait and Nur Aida Sulaiman from Embassy of Malaysia joined the show

Khin Mar Thi from Myanmar Embassy, Cristina G. Juan, Sabina C. Moreno,  Corazon Digna C. Moreno of Philippines Embassy, Patricia Teh Spouse of Head of Mission of Singapore , Van Tramy, Felicia Tohp and  Choo Souw Hwa from Singapore Embassy attended the conference. M.L Piyawan Gongsakdi Spouse of Head of Mission of Thailand and Rachaneekorn from Thailand Embassy were the participants.

Bui Thi To Lan Spouse of Head of Mission of Vietnam, Doan Thi Hoa, Tran Thi Linh, Nguyen Thu Hoai, Nguyen Thi Minh Hue,  Duong Hong Lien, Vu Thi Hue, Vu Hoang Oanh, Tran Thi Thuy Linh from Vietnam Embassy participated in the summit.

“I extend my heartiest thanks to each and every dignity present here and respect your decision and gesture which has touched me a lot. I am always there to support all the countries for the promotion of art and culture,” thanked Dr. Sandeep Marwah. He presented his book on accomplishments and accolades to everyone.

[lemaupertus]

https://e3o.org/e3o/covid-19-photographie-dun-cas-modere-et-de-sa-reponse-immunitaire/

COVID-19 : Photographie d’un cas modéré et de sa réponse immunitaire

Ces chercheurs de l’Université de Melbourne veulent lancer, avec cette étude de cas, un message d’espoir : oui notre système immunitaire peut vaincre le nouveau coronavirus SARS-CoV-2, même lorsque l’épidémie COVID-19 est déjà déclarée. L’équipe australienne qui a cartographié les réponses immunitaires d’un des premiers patients australiens atteint de COVID-19, démontre ici la capacité du corps à combattre le virus et à se remettre de l’infection. Une explication qui confirme le taux de récupération très élevé déjà constaté, soit plus de 80% des cas légers à modérés. Une description de cas également très instructive, présentée dans Nature Medicine.   Les chercheurs du Doherty Institute ont testé des échantillons de sang du patient, à 4 moments différents de la maladie. La patiente était une femme par ailleurs en bonne santé, âgée de 47 ans, revenant de Wuhan et qui présentait des symptômes légers à modérés nécessitant une hospitalisation. Ces analyses ont permis ce rapport détaillé de la façon dont la patiente et son système immunitaire ont répondu au virus. L’un des auteurs, le Dr Oanh Nguyen, explique que cet examen a été effectué « avec tout le recul des connaissances acquises au fil des années » via le suivi des réponses immunitaires de patients hospitalisés pour d’autres maladies virales, comme la grippe. Quelle évolution de la maladie et de la réponse immunitaire au SARS-CoV-2 ?   Les symptômes ont commencé 4 jours avant l’admission à l’hôpital : léthargie, mal de gorge, toux sèche, douleur thoracique pleurétique, dyspnée légère et épisodes de fièvre ; lors de l’admission, au jour 4, l’examen clinique a révélé une température de 38,5 ° C, une fréquence cardiaque de 120 battements par minute, une pression artérielle de 140/80 mm Hg, une fréquence respiratoire de 22 respirations par minute et une saturation en oxygène de 98% ; Le même jour, le SRAS-CoV-2 a été détecté dans un échantillon d’écouvillon nasopharyngé par PCR, puis a de nouveau été détecté aux jours 5 à 6 dans des échantillons du nasopharynx, des expectorations et des selles, mais était redevenus indétectable à partir du 7e jour ; toujours lors de l’admission, jour 4, la protéine sanguine C-réactive était élevée à 83,2, avec un compte normal de lymphocytes (4,3 × 109 cellules par litre (fourchette, 4,0 × 109 à 12,0 × 109 cellules par litre)) et de neutrophiles (6,3 × 109 cellules par litre (fourchette, 2,0 × 109 à 8,0 × 109 × 109 cellules par litre)). Aucun autre pathogène respiratoire n’a été détecté. Aucun antibiotique, stéroïde ou antiviral n’a été administré ; le lendemain, jour 5, la radiographie thoracique a révélé des infiltrats bi-basaux qui ont disparu au jour 10 ; 3 jours après l’admission du patient, soit au jour 7, les chercheurs observent de grandes populations de plusieurs cellules immunitaires, qui, chez les patients atteints de la grippe saisonnière, sont souvent un signe révélateur de rétablissement ; au jour 11, la patiente a été renvoyée chez elle, à l’isolement ; 3 jours plus tard, soit 6 jours après l’admission, au jour 13, la patiente était complètement rétablie ;     Ainsi, si COVID-19 est provoqué par un nouveau coronavirus encore mal connu, les chercheurs observent une réponse immunitaire robuste, similaire à ce qu’ils observent habituellement pour la grippe, à travers différents types de cellules immunitaires et associée à une récupération clinique, .     Une plateforme d’analyse d’avant-garde : cette recherche a pu être menée grâce à la plateforme SETREP-ID (Sentinel Travellers and Research Preparedness for Emerging Infectious Disease), qui permet l’analyse d’un large éventail d’échantillons biologiques par exemple venant de voyageurs de retour de l’étranger en cas de nouvelle épidémie infectieuse inattendue. La plateforme était donc tout à fait adaptée à COVID-19 et les protocoles déjà en place pour examiner en détail la réponse immunitaire au virus.   Les chercheurs souhaitent partager leurs méthodes avec d’autres équipes pour comprendre les réponses immunitaires dans des cohortes plus larges de COVID-19, et pouvoir identifier les « failles » pouvant expliquer les conséquences fatales du virus chez certains patients. Source: Nature Medicine 16 March 2020 Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 Plus sur COVID-19 Équipe de rédaction Santélog Cet article COVID-19 : Photographie d’un cas modéré et de sa réponse immunitaire est apparu en premier sur Santé blog. ARTICLE COMPLET SUR : blog.santelog.com/2020/03…

#Coronavirus

[ptbestprofitfuturespontianak]

Bestprofit - Peneliti Petakan Respons Imun Pasien Corona

PT.Bestprofit – Peneliti Petakan Respons Imun Pasien Corona | PT Best Profit Futures Pontianak

Bestprofit (31/03) - Peneliti Melbourne telah memetakan respons imun dari salah satu pasien virus corona pertama Australia yang menunjukkan kemampuan tubuh untuk melawan virus dan pulih dari infeksi.

Para peneliti di Peter Doherty Institute untuk Infeksi dan Kekebalan (Doherty Institute), perusahaan patungan antara University of Melbourne dan rumah sakit Royal Melbourne, menguji sampel darah pada empat titik waktu berbeda pada wanita sehat yang berusia 40-an.

Nature Medicine membuat laporan terperinci tentang bagaimana sistem kekebalan tubuh pasien merespons virus. Salah satu penulis, rekan peneliti Dr Oanh Nguyen mengatakan bahwa ini adalah pertama kalinya tanggapan kekebalan yang luas terhadap Covid-19 dilaporkan.

"Kami melihat luasnya respons imun pada pasien ini menggunakan pengetahuan yang telah kami bangun selama bertahun-tahun dalam melihat respons imun pada pasien yang dirawat di rumah sakit dengan influenza," kata Dr Nguyen.

"Tiga hari setelah pasien dirawat, kami melihat populasi besar dari beberapa sel kekebalan, yang seringkali merupakan pertanda pemulihan selama infeksi influenza musiman, jadi kami memperkirakan bahwa pasien akan pulih dalam tiga hari, itulah yang terjadi."

Tim peneliti dapat melakukan penelitian ini dengan sangat cepat berkat SETREP-ID (Wisatawan Sentinel dan Kesiapsiagaan Penelitian untuk Penyakit Menular yang Muncul), yang dipimpin oleh Dokter Penyakit Menular Rumah Sakit Royal Melbourne, Dr Irani Thevarajan di Doherty Institute.

SETREP-ID adalah platform yang memungkinkan pengambilan sampel biologis secara luas untuk dilakukan pada para pelancong yang kembali jika terjadi wabah penyakit menular yang baru dan tidak terduga.

"Ketika Covid-19 muncul, kami sudah memiliki etika dan protokol sehingga kami dapat dengan cepat mulai melihat virus dan sistem kekebalan tubuh dengan sangat terperinci," kata Dr Thevarajan.

PT Bestprofit Futures Sumber : Investing

[workcamp2017-blog]

Medical Clinic Field Notes

by Bùi Thanh-Hằng

The medical team with Dr. Hang Bui at center. (Photo by Dan Q. Dao)

Finally, the medical clinic day has arrived. The medical team consisted of 5 physicians: Dr. Hoang Phi, an internist from Houston, TX, Dr. Mai Anh Mai, an internist from Saigon, Dr. Thai Nguyen, an internist, Dr. Tito Nguyen, à radiologist and acting pharmacist, and myself, an ear, nose, and throat doctor from Orange County, CA. Dr. Bich Loan Pham, a pharmacist from Saigon, had obtained all the medications we needed about 3 months before this trip. We also had assistance from Dalton Bui and Tri Pham in the pharmacy department and Kim-Oanh Phi, Thanh Bui, and Stephanie Nguyen in the registration and check-in department. Our medical clinic was set up in an old and shabby house belonging to the local government. It had an antique tractor in the corner, which cannot be moved. We arranged 4 old school tables for the 4 physicians and several tables for the medications for our pharmacy department.

By 9 AM, when we arrived to the clinic, our patients were already waiting for us in front of the clinic. We immediately went to work: measuring blood pressure and weight, directing patients to the physicians and to the pharmacy counter. We had several Red Cross volunteers assisting patients from station to station. Our first patient, an elderly woman in her 80's who could not walk, had to be piggy-backed by her grandson to the clinic. Moving from station to station, she has to be carried. All patients were older than 65, yet they appeared to be much older than their age. One by one, each patient got to see an internist and were referred to me for any ear, nose, and throat problems. The number of patients increased rapidly, and we had a temporary backlog. I was asked to see more patients, usually those who had back, leg, arm pain, without any internal medical problems.

Elderly folks queue up for a visit to the Sunflower Mission medical clinic (Photo by Dan Q. Dao)

One 68 year-old patient complained of the usual back pain that keeps her awake at night. It turned out on her exam that she had severe ear bone erosion and complete ear drum perforations due to chronic infection. However, the chronic ear drainage and hearing loss were not priority on her list. She has been living with severe hearing loss and has accepted it as facts of life. It was the back pain that she wished to seek treatment. I thought how in United States, we ENT specialists would panic to find such severe ear diseases. We would immediately obtain a CT scan and advise immediate ear surgery since severe chronic ear infections would cause intracranial complications, meningitis and death. Looking at my patient, she seems to be adjusting quite well with her ear problems. I quietly advised her to keep her ears dry, and prescribed antibiotic ear drops and antibiotics if her ears got worse, and pain medications for her back pain. She laughed shyly when I told her to do back exercises and bedrest. She told me gently: "I have to work everyday, chopping woods, to keep foods on the table for my family."

In the afternoon, after we have seen about 200 elderly patients, we went back to the school site to help the pediatricians and dentists to finish seeing the remaining 120 children. The  line was so long, and the children were mostly accompanied by an older sibling (older by 1-3 years). I saw mostly healthy children with poor dentition. One 8 year-old child had very large tonsils. He had difficulty with swallowing, loud snoring and apnea at night. By appearance, he looked like a 5 year-old.  I advised his mother to bring him to see an ENT specialist to get the tonsils removed. He would definitely eat and swallows better and will grow normally.

It was a rewarding experience. Even during brief contacts with the patients, the stories of their lives have profoundly touched me. Thinking about how I was so burned out in the last few months with my solo practice, with the amount of unnecessary paper works, uninvited interference from insurance companies, government rules and regulations, billing problems, and hiring and dismissing employees, I now have a different outlook in life. I hope that I will be able to go back to work in a better state of mind, appreciating what I have to face with everyday, my problems are really minimal compared to what my patients in Tam-Kỳ, Quang-Nam have to face throughout their lives.

[greggsdiabetes-blog]

Experts urge use of evidence-based medicine to avoid overtreatment of type 2 diabetes

New Post has been published on http://www.greggsdiabetes.com/experts-urge-use-of-evidence-based-medicine-to-avoid-overtreatment-of-type-2-diabetes/

Experts urge use of evidence-based medicine to avoid overtreatment of type 2 diabetes

UT Southwestern Medical Center research supports an evidence-based medicine (EBM) approach that embraces individualized care to prevent overtreatment, specifically for patients with type 2 diabetes.

This recommended strategy is outlined in a review article published recently in Circulation.

Medical care overuse accounts for approximately 20 percent of the estimated $750 billion of wasteful spending in health care in the United States, according to the National Academy of Medicine.

While there are many factors that drive overuse, the authors propose that applying the principles of EBM — which includes balancing absolute benefits and harms with the physician’s judgment and the patient’s values and preferences — helps to avoid overtreatment. The review is intended to be a call to action for physicians, medical educators, researchers, and policy leaders to apply EBM principles to individualize treatment decisions and to improve the health and well-being of patients.

“Evidence-based medicine is a powerful tool to provide person-centered care to individuals with type 2 diabetes, as well as for patients with other diseases,” said Dr. Anil Makam, Assistant Professor of Internal Medicine at UT Southwestern and lead author of the article. “When applied to type 2 diabetes, EBM calls for a paradigm shift in our treatment approach.”

To prevent overtreatment, the researchers propose that intensive blood-sugar treatment should not be a universal goal of patient care for those with type 2 diabetes, which according to the Centers for Disease Control and Prevention affects more than 29 million people in the United States.

While the current standard of care for type 2 diabetes calls for strict control of blood sugars (defined as a hemoglobin A1c level of less than 7 percent), evidence shows that this strategy offers only a modest potential benefit — and it can decrease quality of life due to the burden of treatment itself and possible harm from therapy. Also, because it takes up to two decades of strict blood-sugar control to potentially achieve meaningful benefit, many frail and older individuals can be successfully treated by achieving more modest blood-sugar goals (hemoglobin A1c levels of 8.5 to 9 percent) that maintain the benefits of treatment while minimizing potential harm.

“EBM is often misunderstood as a call for universal, cookie-cutter medicine, which has led to an epidemic of overtreatment in type 2 diabetes,” said Dr. Oanh Nguyen, Assistant Professor of Internal Medicine and Clinical Sciences, and senior author of the article. “Instead, EBM is a critical tool in the physician’s arsenal to provide individualized and person-centered care.”

Story Source:

Materials provided by UT Southwestern Medical Center. Note: Content may be edited for style and length.

  Original Article