#Influenza

[queeroldweapon]

It’s cold/flu/covid season again, please wear your goddam masks and get vaccinated if you’re able to

[reasonsforhope]

"A team of researchers at Washington University in St. Louis has developed a real-time air monitor that can detect any of the SARS-CoV-2 virus variants that are present in a room in about 5 minutes.

The proof-of-concept device was created by researchers from the McKelvey School of Engineering and the School of Medicine at Washington University...

The results are contained in a July 10 publication in Nature Communications that provides details about how the technology works.

The device holds promise as a breakthrough that - when commercially available - could be used in hospitals and health care facilities, schools, congregate living quarters, and other public places to help detect not only the SARS-CoV-2 virus, but other respiratory virus aerosol such as influenza and respiratory syncytial virus (RSV) as well.

“There is nothing at the moment that tells us how safe a room is,” Cirrito said, in the university’s news release. “If you are in a room with 100 people, you don’t want to find out five days later whether you could be sick or not. The idea with this device is that you can know essentially in real time, or every 5 minutes, if there is a live virus in the air.”

How It Works

The team combined expertise in biosensing with knowhow in designing instruments that measure the toxicity of air. The resulting device is an air sampler that operates based on what’s called “wet cyclone technology.” Air is sucked into the sampler at very high speeds and is then mixed centrifugally with a fluid containing a nanobody that recognizes the spike protein from the SARS-CoV-2 virus. That fluid, which lines the walls of the sampler, creates a surface vortex that traps the virus aerosols. The wet cyclone sampler has a pump that collects the fluid and sends it to the biosensor for detection of the virus using electrochemistry.

The success of the instrument is linked to the extremely high velocity it generates - the monitor has a flow rate of about 1,000 liters per minute - allowing it to sample a much larger volume of air over a 5-minute collection period than what is possible with currently available commercial samplers. It’s also compact - about one foot wide and 10 inches tall - and lights up when a virus is detected, alerting users to increase airflow or circulation in the room.

Testing the Monitor

To test the monitor, the team placed it in the apartments of two Covid-positive patients. The real-time air samples from the bedrooms were then compared with air samples collected from a virus-free control room. The device detected the RNA of the virus in the air samples from the bedrooms but did not detect any in the control air samples.

In laboratory experiments that aerosolized SARS-CoV-2 into a room-sized chamber, the wet cyclone and biosensor were able to detect varying levels of airborne virus concentrations after only a few minutes of sampling, according to the study.

“We are starting with SARS-CoV-2, but there are plans to also measure influenza, RSV, rhinovirus and other top pathogens that routinely infect people,” Cirrito said. “In a hospital setting, the monitor could be used to measure for staph or strep, which cause all kinds of complications for patients. This could really have a major impact on people’s health.”

The Washington University team is now working to commercialize the air quality monitor."

-via Forbes, July 11, 2023

-

Holy shit. I know it's still early in the technology and more testing will inevitably be needed but holy shit.

Literally, if it bears out, this could revolutionize medicine. And maybe let immunocompromised people fucking go places again

Also, for those who don't know, Nature Communications is a very prestigious scientific journal that focuses on Pretty Big Deal research. Their review process is incredibly rigorous. This is an absolutely HUGE credibility boost to this research and prototype

[yesterdaysprint]

The Grainfield Cap Sheaf, Kansas, January 16, 1914

[vintage-sweden]

"Seth and Greta, reunited after Spanish flu", 1919, Sweden.

[weirdlookindog]

Otto Seitz (1846-1912) - The Black Kitchen of Death

illustration from Jugend #24, 1896

[covid-safer-hotties]

Pt 1 (source)

[reality-detective]

Influenza drugs in 1959 🤔

[guavagyal]

still wearing a mask because people in my area think it's their right to spread viruses and think they're too cute to wear one (and they never are!)

[blackpinkofficialupdates]

[240624] Jisoo weibo update

Thank you Xiuqi! I love you ❤️

[ollyvoile]

Add your reasons, if you like!

Other people have added these:

• Yellow fever @notoverjoyed

• Scurvy @monitorchakas

• Lymph disease @wyrmalien

• Diphtheria ( I couldn’t fit this one)

• Malaria “ye olde marsh fever” @bombadilbaddie

• Scrofula “The King’s Evil” @hasturswig

Edit for all the people telling me “uhhh tuberculosis still exists”: I know! :) In fact, all of these sicknesses still exist. In the modern world we live in, however, most of these are only prevalent in developing countries, and certainly not to the extent they once were.

[auradaparanormal]

Look what I found

A while back I had an idea for a TPOT fanmade episode called "Weathered Woes" where the general premise was:

Two catches the flu, making their powers go haywire (more specifically they cause a major blizzard), but they disguise it by saying that they're making a snow day for everyone.

The challenge is to build a fort against the weather, but whilst the challenge happens, Gaty notices that Two seems less energetic and cheery. At some point, the storm reaches its worst and everyone forfeits the challenge and retreat into the hotel. Gaty realises that Two is still outside and that she needs to confront them about this. She finds Two and is basically like "Somethings wrong, but I can help!" But Two's like nuh uh then Gaty's like Yuh huh then two finally caves in and admits that they feels scared that everyone won't want to stay with them if they aren't a good host. Gaty consoles them and tells them that they need to go inside. Two obliges and collapses in an empty hotel room.

A cute little bit that would be at the end would be Gaty asking if she could announce who's up for elimination and Two is too tired to argue so they say "Yeah sure *violently coughs*"

(I also vividly remember creating the whole episode in my head and it was so angsty for no reason 😭)

[disease]

Making the vaccine against the Influenza Outbreak of 1957.

[thebookishwallflower]

I want to make a post to inform people about the current situation with the bird flu (/avian flu/H5N1) outbreaks.

I don't want to cause panic but do want to spread information.

This is especially important if you live in an area that has a news system you don't trust to give accurate, timely, or honest news about something like a possible new pandemic, use your own judgement.

If that applies it is going to be very important to make sure you stay informed and follow these H5N1 outbreaks yourself and know how to best protect yourself.

I am no expert, but I do know a good bit about disease and influenza in particular, and have been following the H5N1 outbreaks as they've been happening, so under the cut I'm going to do my best to inform everyone I can.

Please stay safe, stay informed, and spread information, not germs.

What's bird flu and why do I care? (What's bird flu and why do I care?)

Avian flu and bird flu mean the same thing, an influenza virus that (primarily) infects birds. H5N1 denotes a specific strain of avian influenza. H5N1 can spillover (when a pathogen spreads from it's normal host organism to a new host organism) from animals to humans.

How could I get H5N1? (How could I get H5N1?)

Human to human transmission has not been observed yet (12/1/24) during this current outbreak. You can get this from contact with wild birds, especially water fowl, domestic birds, cattle, pigs, horses, dogs, and bats. It is also possible to get from raw (unpasteurized) milk and undercooked meat from infected animals.

What's the big deal then? (What's the big deal then?)

The common flu is not very pathogenic. How pathogenic something is determines how sick something makes the host, something that is highly pathogenic can cause severe disease. H5N1 is considered a HPAI, Highly Pathogenic Avian Influenza.

H5N1 is also a Type A influenza virus, most known Type A influenza viruses can infect birds. There is one Type A human flu in circulation at the moment, however it isn't very prevalent.

"IAV poses a significant risk of zoonotic infection, host switch, and the generation of pandemic viruses. IAVs can infect humans and a variety of animals, such as pigs, horses, marine mammals, cats, dogs, and birds (S1)."

IAV - Influenza A Viruses | Zoonotic infection - when an infectious disease of a non-human host infects a human host | Host switch - when a cross-species transmission of a pathogen can lead to successful, stable, and continuous infections

Every species the flu infects, the more strains that pop up under a sub-type IAV, the possibility for recombination increases. "Recombination occurs when at least two viral genomes [or strains] co-infect the same host cell and exchange genetic segments (S2)."

The flu is pretty good at recombination, when given the chance. It is also really good at mutating, and fast. If there were to be a recombination event and a new strain evolved (this would be called an antigenic shift) that was highly pathogenic, highly infectious (good at spreading, which H5N1 is), that could then infect humans and cause human-to-human transmission we might have a pandemic on our hands. This has not shown signs of happening during this outbreak*, this is what to look out for.

This (a recombination event) is what caused the 1918 pandemic during WW1. This pandemic killed an estimated 50 to 100 million people in 1918, in a world with a population of around 2 billion. 7.1 million died of COVID 19, as of 11/9/24 (S3), from a population of around 8 billion.

We know more, we are prepared, it's not guaranteed to happen, and it's not guaranteed to be as bad. But the possibilities are endless and it's extremely important to be prepared and stay informed.

So what do I do? (So what do I do?)

Again, stay informed, and that might mean checking independent news sources, the CDC website, and more, to keep yourself updated, especially if you know your local news won't do it for you. You should also familiarize yourself with the symptoms of influenza, if you have it, stay home.

Keep yourself safe, we had a pandemic already, you know the drill. Cover your nose and mouth when sneezing/coughing, wash your hands, sanitize your hands, and get your flu shot. And, in addition, avoid contact with wild birds, poultry, pigs, and cattle if you can.

In the event that this gets worse, social distancing is very important, being outdoors, wearing a mask, and all the stuff above, you can shed the virus for around a week before you start feeling bad. Keep yourself safe and don't infect anyone else.

If that doesn't sound like it'll do much, I promise you it does. Those are all classified NPI's (non-pharmaceutical interventions) and even epidemiologists were shocked at their impact and importance during the COVID-19 pandemic. They did work, and they were incredibly effective—as long as they were carried out.

I don't want to cause panic or worry anyone, but that is how information ends of suppressed. I want to make everyone aware of what we might face so that we can fight it and be strong and stay safe.

If anyone has any questions, wants any clarification, any corrections, or wants to know some good places to learn more about this stuff please don't hesitate to contact me (@'s, dm's, or asks), I will answer as best I can.

Here's the CDC's page covering the H5 bird flu current situation.

S1 - https://pmc.ncbi.nlm.nih.gov/articles/PMC5578040/

S2 - https://pmc.ncbi.nlm.nih.gov/articles/PMC7106159/

S3 - https://data.who.int/dashboards/covid19/deaths?n=c

*with the exception of this coverage (as a possibility): https://www.theguardian.com/world/2024/nov/19/bird-flu-cases-mutation-canada

[whimsimarion]

Hey, guys! Remember Influenza? The daughter of the couple who went to live in Asterix' village after they were mistaken it belonged to them in "Asterix and Caesar's Gift"?

I brought her up mainly because I wanted to say that she was totally valid into falling in love with Asterix.

What a man, indeed!

[scientificinquirer-blog]

Could a bout of COVID protect you from a severe case of flu?

More than 200 viruses can infect and cause disease in humans; most of us will be infected by several over the course of a lifetime. Does an encounter with one virus influence how your immune system responds to a different one? If so, how? Does it weaken your defenses, boost them, or have some other impact altogether? These are questions Rockefeller University scientists from the Laboratory of…

[ricisidro]

The H1N1 influenza A virus is indeed the agent of the 1918 Spanish flu and the ancestor of all subsequent flu pandemics.

The 1918 virus is believed to be of avian (relating to birds) origin and adapted to humans.

The enigma of the 1889 - 1894 flu pandemic (Russian Flu)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813723/

The origin of the 1918 -1919 influenza virus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1088558/

1918 Influenza (Spanish Flu): the Mother of All Pandemics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291398/