#Coxiella burnetii

[pierre-hector]

Armes biologiques : qui fait quoi ?

Par Dilyana Gaytandzhieva, journaliste d'investigation bulgare (1).

« L'unité A1266 du Pentagone et des scientifiques locaux ont collecté 40000 tiques dans 13 régions du Kazakhstan et isolé quatre bio-agents qui constituent une grave menace de bioterrorisme : virus de l'encéphalite à tiques (TBEV), virus de la fièvre hémorragique de Crimée-Congo (CCHFV) [Ébola], Rickettsia et Coxiella burnetii (l'agent causal de la fièvre Q). Ces bio-agents ont le potentiel d'être conçus pour la diffusion massive d'aérosols et utilisés comme armes biologiques. [...]

Le programme du Pentagone sur les tiques et les maladies transmises par les tiques au Kazakhstan a débuté il y a dix ans, selon l' étude publiée par la National Library of Medicine des États-Unis en 2016. “Nous disposons de nouvelles données substantielles sur une maladie grave transmise par les tiques en Asie centrale, de l'importance à la fois pour les autorités de santé publique locales et mondiales, ainsi que pour le DoD américain”, affirment les chercheurs. Tous les bio-agents qui ont été découverts dans des tiques infectées au Kazakhstan dans le cadre du programme DoD ont été étudiés comme des armes biologiques potentielles dans le passé. […]

Recherche sur les coronavirus

Un autre projet du Pentagone a étudié les coronavirus chez les chauves-souris (2015-2018). Au total, 200 échantillons de guano de chauve-souris ont été collectés dans trois grottes du Kazakhstan. Dans l'ensemble, 25 (12,5%) de tous les échantillons de guano testés étaient positifs pour les coronavirus. Cette étude a été financée par le projet de recherche biologique coopérative KZ-33 : MERS Coronaviruses : Surveillance and detection in Kazakhstan. [...] » (Dilyana Gaytandzhieva) (trad. Google)

Lire la partie concernant la peste noire à l’aide de Google Chrome (par exemple).

« L'Agence de réduction des menaces de défense (DTRA) a dépensé près de 300 millions de dollars pour deux laboratoires de biosécurité de niveau 3 (BSL3) au Kazakhstan depuis 2009 : le Laboratoire central de référence à Almaty (également connu sous le nom de Centre scientifique kazakh de quarantaine et des maladies zoonotiques (KSCQZD), et l'Institut de recherche sur les problèmes de sécurité biologique (RIBSP) à Otar, révèlent des documents du registre des contrats fédéraux des États-Unis.

DTRA a sous-traité une grande partie du travail à des entrepreneurs privés américains. AECOM Government Services a remporté un contrat de 240,4 millions de dollars pour la construction des deux laboratoires BSL 3 (2009-2016). Une autre société américaine CH2M Hill a reçu deux contrats fédéraux : un contrat de 38,4 millions de dollars pour des services scientifiques (20 août 2015 - 31 août 2020) et 17,2 millions de dollars supplémentaires pour l'ingénierie et la livraison d'équipements (31 janvier 2020 - 2 février 2023).

Ces installations américaines au Kazakhstan ne sont que deux des nombreux biolaboratoires du Pentagone dans 25 pays à travers le monde. Ils sont financés par la Defense Threat Reduction Agency (DTRA) dans le cadre d'un programme militaire de 2,1 milliards de dollars - Cooperative Biological Engagement Program (CBEP), et sont situés dans des pays de l'ex-Union soviétique tels que le Kazakhstan, la Géorgie et l'Ukraine, le Moyen-Orient, l’Asie du Sud-Est et l’Afrique.

Les laboratoires Bio-Safety Level 3 sont accessibles uniquement aux citoyens américains disposant d’une autorisation de sécurité. » (Dilyana Gaytandzhieva) (trad. Google)

‣ Dilyana Gaytandzhieva, « Pentagon Unit A1266 studies bioterrorism agents in Kazakhstan » (« L'unité A1266 du Pentagone étudie les agents de bioterrorisme au Kazakhstan »), pub. 21 juil. 2020, http://armswatch.com/pentagon-unit-a1266-studies-bioterrorism-agents-in-kazakhstan/ (cons. 21 juil. 2020). — (1) « Dilyana Gaytandzhieva est une journaliste d'investigation bulgare, correspondante au Moyen-Orient et fondatrice d'Arms Watch. Au cours des deux dernières années, elle a publié une série de rapports révélateurs sur les livraisons d'armes aux terroristes en Syrie et en Irak. Son travail actuel se concentre sur la documentation des crimes de guerre et des exportations illicites d'armes vers les zones de guerre du monde entier. – http(:)//armswatch(.)com » (trad. Google) —

[yesusagisanworld]

Advent Calendar Q熱感染を語るぞ！

アドベントカレンダー！！ に見せかけたお正月記事になりました。遅くなり大変申し訳ない。

というのも、なんということでしょう。投稿が消えてしまいました事件が起きていたのでした。

山梨ロスト――……

からの復活。 もう一度文章を作ってみました。頑張ったね！私よ！！

そして今回はQ熱感染について語りたいと思います。

昨年も沢山の方に遊んでいただけました。

また、Q熱感染はさておき、少しずつ呪印感染そのものの認知度も上がってきているようにも、Twitterなんかを見ていると思います。 プレイ人口が増えるの、とっても嬉しいね！

その中でタマミさん経由で、箪笥ルールが少々特殊だったり、独自の進化を遂げているようだったりということが判明したりなんかして。始めてから3年？くらいになるのに、まだまだ新しい発見もあったゲームでした。愛しているよ！

さて、話題を戻してQ熱感染です。

箪笥発呪印感染シナリオの三作目であります。 （pest氏こと先生の全十作→たまみさんのあざら印感染全十作→Q熱の全十作！ Takanashi→Azarashi→Yamanashiって、韻を踏んで覚えていってね！ちなみに、お二人の影響を受けた部分やシナリオ中のオマージュがあるんだけど、ネタバレになってしまうのでここでは言えないよ！）

そして、Q熱ってなんなの？ということで、よく質問される名前の由来は至って普通！

Q熱とは

Q 熱は重要な人獣共通感染症の一つで、1935年オーストラリアの屠畜場の従業員の間で流行した原因不明の熱性疾患として発見され、のちにリケッチアの一種Coxiella burnetii による感染症であることが明らかにされた。Q熱という病名は、「Query fever ＝不明熱」に由来している。

うさぎ作のシナリオだったので、ウサギ・ヒト共通感染症の名前からとりました。それ以上の意味は現状ありません。

むやみに意味をこじつけるとしたら、QuestionのQとか？それでAnswerができたらA？と考えましたが、A熱は存在しないので、そのこじつけは恐らくしません！数日後にやっぱその路線でいきますとか言い出したら私の掌ドリルを面白がっていただけますと幸いです。

とりあえず言いたいことは「うさぎ作」ということ。

そしてなんと本作、ステージが山梨ではないのです。

政令指定都市があると良いな（なぜならダイス表の「都市表」を使用するから）と思って……設定したのは…………

静岡県です。 魂は売っていません。 被害となった地として選んだだけです！！！！！

では、ここからはネタバレのお時間！！！！！

まだ十話分プレイしていない人＆プレイ予定がこれからの方はここでバックだ！

プレイしていないけれども、呪印感染に興味があるよ、という方はぜひ去年の記事を読んで貰えると嬉しいな。 お付き合いありがとう！！

⚠ スクロールしたらネタバレがくるぞ～ ⚠

--------------------------------------------------

このくらいでいいか！？

良さそうだね！では！

--------------------------------------------------

【Q熱感染 黒・ストーリー】

6年前に流行した『感染』というタイトルの連続短編小説。 十人の新人作家たちによって作られた十話のオカルト話。

それは『呪印』という20世紀末ごろに出回ったオカルト話を元としたストーリーであり、さらには怪異を生むための設定集そのものであった。

呪いは、怪異は、尾ひれはひれ付き、ゆっくり姿を変えていきながら、ついには現代の〈呪印者〉たちの目の前に、利き手の甲に、現れる。日常は徐々に恐怖に侵食されていく。

その中で過去の存在である、『喪服の男』こと『１』にエンカウントしたり、 キーマンである『七海 享』から過去を聞いたり、 その他諸々の怪異の存在や『零泉月詠』を調べたり……、

最終的に〈呪印者〉たちはこの世界を玩具にしている『天帝』という存在（PL・GMそのもの）にたどり着き、 そしてこの世界（呪印感染の世界そのもの）の未来をPLでもGMなく、PCである〈呪印者〉自身が決定していく。

という感じになります！

展開としては、

前半は世界観と『うさぎ性癖ホラー』、さらにゲームシステムに慣れてもらい、 後半でメタフィクション要素をはじめとするオリジナル要素・ルールをぶち込んで、 最終的に［呪印］そのものがなくなり、全てから〈呪印者〉たちは解放されて自由になる。すべて解決！大団円！

みたいな流れとなっております。

プレイ済みの方は、だいたい思い出していただけたでしょうか……？

そして！

【全十話 タイトル・怪異名一覧（正規ルート）】

一人歩きするはじまりの怪異　・１ 二人といない大切な君へ　　　・二人静の妄執 三界に咎は無し　　　　　　　・三尸の紙魚 四大空に帰す　　　　　　　　・四つ辻の名無し 五線譜は知っていた　　　　　・Victoria Theatre 六芒星の加護の中で　　　　　・六臂の土蜘蛛 七回忌　　　　　　　　　　　・七編版『感染』 / 七海 享 八首を産みし嘘八百　　　　　・八卦見 九曜の棄捨せし最終稿　　　　・九相図の垂乳根 拾��の名前と呪印感染　　　　・十さん

全話タイトル・怪異名がこちらになります！

もうお気づきだと思うのですが、タイトルの最初の一文字が漢数字で一〜十（「拾」は「十」の大字）となっております。

また、登場する怪異にはそれぞれ怪異名という物が設定されており、そちらも数字縛りの名称となっています（第五画目についてはローマ数字の「V」）。

結構言葉遊びというか、ダジャレ的なネタも含めながらのタイトル・怪異名で、いつもこねくり回しながら作るのが楽しかった記憶があります。ただ全部オリジナルなので、大変難しかったけれどもね！

また、いつもおなじみの『導入前導入』。

回のはじめに必ず読み上げられる部分があり、その後にまともな導入が入る作りがデフォでした。

この［呪印感染］の世界がすべて小説からつくられた設定であるため、連続短編小説『感染』該当回の冒頭数行を『導入前導入』として設定していたという小ネタがありました。（もちろんタイトル・怪異名の数字縛りもこの連続短編小説『感染』が前提にあるからこその縛りです！）

こちらはタイトル・怪異名以上に難産で、頭にすっと入っていきやすい文章ってどうやって作るんだろう？？といつも唸りながら書いていた部分です。

文字書きさんってわかってはいたけれどもやっぱりすごいのね……。

そして、

ここまでは、物語の大筋に関わってくる連続短編小説『感染』についての小ネタやら、設定していた理由やらでしたが、

ここから先は、完全に制作裏話。ストーリー作りで考えていたことやら、全十話の順番やらについてのざっくりした話をしたいと思います。

【全体のストーリーづくりについて】

なんと最初に内容が確定した画数は第七画目でした！！

最初から画数ごとのタイトルと画数の数字で遊びたいと考えており、 とってもシンプルにちょっと不気味な過去の話をするとしたら、どういうタイトルの話がいいかな？と考えて出てきたのが「七回忌」。

数え年のため六年前から現代に続く、不気味な話をすることができるのでは？というところから書き始めました。

そして勿論七回忌なので、最低でも死者と生者の2人が必要になってくることで、生者（語り手）として『七海 享』がつくられます。

さらに、七画目は後半戦半ばなので、それまでに登場した怪異を死者側でしたよ、という伏線回収をしたいと考え、第一画目に人の形をした怪異を連れてくることに決定した。

というのが……すべての発端でした。

その後に考えたことは、

「十画すべて終わって、ひとまずは解決したけど、これ再度［呪印］が現れる可能性があるのでは？」

という、［呪印感染］の世界そのものに対しての不安感。

でもこれってジャパニーズホラーだから、そういう「まだ続いてしまうかも……」といった、 いつ非現実に導かれるかわからない理不尽さが残る展開ってよくある上、個人的に好きなものなんですが、

「それら全部を解決してみたくない！？ならどうしたらいいのかな！？」とハッピー頭による疑問がわきました。

出てきた答えが「PL・GMがいるからどうしようもないですね！」 → 「なら第四の壁が見えるようになって逃れる術を持てば良いのでは！」

これによって、メタフィクション要素がガッツリ搭載される流れとなりました。

ここで、第十画目の内容が「PL・GMを敵に回す」とざっくり確定。

同時に第七画目の内容もメタフィクションのために「この世界はフィクションに則っています」ということがわかる話＝小説家『七海 享』による過去の小説の話、と方向性が確定。

ここで、全部の画数をそれぞれ別の人が書いている、とかにしたら面白いのでは？と考え、第七画目と、さらにQ熱黒の世界がカチッと決まりました。

そしてところどころに、フィクションと現実にまつわる話（第五画目）や、PL・GMの存在をちらつかせる伏線回（第三画目）や、うさぎ性癖なんかを散りばめつつ書いている中で、

《伏線》ってなんでこんなに問答無用で強いんだ？小説の話だからか！？と、誰でもお持ちの過去と秘密の《伏線》関係の話を混ぜ込みたくなり、第八画目、第十画目、なんなら第一画目の『喪服の男』周りにセットしておきます。この辺で『喪服の男』の特異性を考え、それを恐れる人間をつくることを考え始めまして、『一宮 朔』の存在はなんとここで決まります。『七海 享』のがずっと先にいたという……。

最後に残るは二・四・六・九画目で、

序盤に『七海 享』が登場しなければという登場回として第二画目（捨てられた女として自覚している伏線回）、

忘れた頃に『ガーデンハイツ八河』を登場させたい&第六画目・第八画目に登場する『祠』の伏線のための第四画目、

中ボス回として&オリジナル《正体》に慣れ始めたPLへの登龍門、第六画目、

最後にラスボス前に気持ちを嫌でもすべてを清算していけPvP回&『零泉月詠』メイン回、第九画目……

の順番で決めていきました。

なお、こちらの記事ではわかりやすさのために上の文章の該当画数に数字を振っていますが、 当時は一画目・七画目・十画目以外はこの数字！とカチッと決めておらず、 前半のこのくらいに〜、後半のこのくらいに〜という配置だけなんとなく決めていました。

順番を決めるために最初は適当に並べてみたんですが、しっくり来なく、そのため、 「伏線をどうやって維持させるか」という観点から、順序をかちっと決めることにしました。

なぜ「伏線をどうやって維持させるか」という観点なのか、 ���う少し詳しく書くと、

［呪印感染］というシステムの中でのPC・〈呪印者〉たちはあまりにも簡単に死にやすい！

Q熱黒は全十話で、どこかで話が途切れた途端に、大事にしていた伏線が全滅してしまう！という課題がつきまとうのです。

それを解決するためにはどうしたらよいのか？？

→死んでも大丈夫なように外付けハードディスクをつけましょう！

→PCの生存をずっと維持し続けるのは難しいため、必ず一定期間までは死なないNPCをちょいちょい登場させて維持させてみては？

→『七海 享』だ！！！

ということで、『七海 享』���早めの第二画目からの登場、次いで第四画目の確定助っ人NPC・第六画目の冒頭で会議を行う・第七画目（メイン回）以降はずっと出ずっぱりにすることに。

［呪印感染］はシステム上、時間切れではない限り必ず1人は生還できるため、 2人プレイで、PCが交互にロストするとかいう器用なことをしたとしてもぎりぎりなんとかなるように、『七海 享』は（序盤は）偶数回にだけ登場するように設定させることにし、 『七海 享』が入り込めそうな隙きのある画数だけピックアップして偶数画数として並べることにすることで、解決&順序を決定するという荒業に出ました……。

が、なんだかしっくり来て個人的にとても満足。

外付けハードの『七海 享』の配置によって順番が決まり、 あとはそれぞれの画数にあったタイトル名と怪異名を〜という、決め方をしました。

（で、これを考えながら同時に白をねりねりしていた。）

といった形での制作裏話でした！！ 『七海 享』に全体的に助けられて作られたわけだ……。 どうもありがとう……。

あんまり参考にならないかもですが、 これから［呪印感染］のシナリオを書きたい人の為に、こんな感じで考えていたよ〜程度のメモとなります。

読んでくださってありがとう！

全部で十話もありますが、

本当に順番ぐちゃぐちゃに作ったので、 順番通りに作る必要ないと思います！

とだけは力強く主張できます。

そして、シナリオを新しく作ったよという方がいらっしゃったら、 是非私にプレイさせていただけると幸いです！

そして、ここまで読んでくださった皆さん。

改めまして、

あけましておめでとうございます。

あの例の一件からおよそ一ヶ月経った頃。 あの事件以来、利き手に痛みが走ることはなく、安心した人もいれば、寧ろ拍子抜けした人もいるかもしれない。

そしてそのままやってきたお正月。何はともあれ貴方達は久しぶりの長めの平和な休日に入った。

幸運なことに、今年は7日までが休みであり、貴方達は本日までの正月休みをゆっくりと満喫できたことだろう。

それにしてもお正月とは賑やかなものである。

どこでも浮かれたように初売りと称したバーゲンセールが行われ、大きな袋に詰められた商品は福袋と名付けられぽんぽんと売れる。

田舎では獅子舞なんかも家を回るのだろう、神社では破魔矢やらお守りやらが売られ、その隣では昨年買われたものが天に帰されるために燃やされるのだろう。

餅付きのイベント、冬休みの今しかやらないであろう、コマ回し、凧揚げをする小学生たち、混雑する新幹線。

あけおめことよろメッセージ、朝早くに郵便局から出発する赤いバイク。そのバイクのエンジン音に目覚めて騒がしく吠える玄関先の犬。

何度も言うが、お正月とは賑やかなものである。

どこか貴方の家の近所でも正月を祝う祭りでもやっているのか、祭囃子のようなものが微かに聞こえてくる。

微かに聞こえる日本人の慣れ親しんだ美しい和音。笛の音、太鼓の音。

神社だけでなく、この時期はテレビでも流れていそうな短調で雅な音色だ。

その祭囃子のテンポに合わせて足音のようなものも聞こえる。随分と賑やかな祭りのようだ。

笛の音に負けず劣らずの美しい歌声も複数聞こえてくる。

ここで貴方達は気がつく。

最初に祭囃子に気がついた時よりも、音が鮮明に聞こえているということに。

移動しながらの催しなのだろうか？獅子舞のように、家々をまわり、道路を練り歩くような催しが近所で行われているのは聞いたことがない。

そんなことを考えている内に、遂に美しい歌声が聞き取れるほどに近付き……

「天まで届けやしずやしず」という女の囁くような声と、

ぴぃ

と、か細い笛の音が。 耳元で聞こえたかのような、不気味な感覚におそわれる。

同時に貴方達の利き手の甲に、しびれるような痛みが走った。

…………

………

……

…

.

本日、ちょうどお目出度い第二画目の日となっております。

『七海 享』とみんなはもう会えたかな？？

今年もどうぞよろしくお願いいたします。

うさぎ

[heathcareforallworld]

Q Fever Market: Size, Share, and Growth Forecast to 2032

Introduction

Q fever is a zoonotic infection caused by the bacterium Coxiella burnetii, which primarily affects animals such as cattle, sheep, and goats but can also infect humans. The disease is typically transmitted to humans through inhalation of contaminated air particles or through direct contact with infected animals or animal products. Although Q fever can range from asymptomatic to severe in humans, it remains a significant public health concern in various parts of the world. This article provides an in-depth analysis of the Q fever market, including its size, share, industry trends, and forecast through 2032.

Market Size and Growth

Q fever Market Size was estimated at 0.21 (USD Billion) in 2023. The Q Fever Market Industry is expected to grow from 0.23 (USD Billion) in 2024 to 0.4 (USD Billion) by 2032. The q fever Market CAGR (growth rate) is expected to be around 7.3% during the forecast period (2024 - 2032). This growth is driven by several factors, including increased awareness of Q fever, improved diagnostic methods, and a rise in zoonotic diseases globally.

Market Segmentation

1. By Product Type:

Vaccines: Vaccination is one of the most effective ways to prevent Q fever, particularly in high-risk populations such as farmers, veterinarians, and abattoir workers. The vaccine segment is expected to grow significantly as governments and health organizations push for broader vaccination coverage.

Antibiotics: Antibiotics like doxycycline are the standard treatment for Q fever. The antibiotics segment holds a significant market share and is expected to maintain steady growth due to the increasing incidence of Q fever globally.

Diagnostic Tests: The market for diagnostic tests is growing rapidly as early detection of Q fever becomes a priority in both human and animal health. This segment includes serological tests, PCR-based assays, and ELISA kits.

2. By Application:

Human Q Fever: The human segment dominates the Q fever market, driven by increasing awareness, improved diagnostic capabilities, and a growing number of reported cases. The rising incidence of Q fever in both endemic and non-endemic regions contributes to the demand for vaccines and treatments.

Animal Q Fever: Although primarily a human health concern, Q fever also affects livestock, leading to significant economic losses in the agricultural sector. The animal segment is expected to see steady growth as the focus on controlling Q fever in animals intensifies to prevent transmission to humans.

3. By Distribution Channel:

Hospital Pharmacies: Hospital pharmacies hold a significant share of the Q fever market, particularly for the distribution of antibiotics and vaccines used in treating acute cases.

Retail Pharmacies: Retail pharmacies are a major distribution channel, especially in regions where Q fever is endemic. They provide easy access to antibiotics and over-the-counter preventive measures.

Online Pharmacies: The rise of e-commerce and online pharmacies is contributing to the growth of the Q fever market, especially in developed countries where online sales of medications are gaining popularity.

Regional Analysis

1. North America:

Market Share: North America holds the largest share of the global Q fever market, accounting for approximately 35%. The region's advanced healthcare infrastructure, coupled with high awareness and reporting of Q fever cases, drives market growth.

Trends: The increasing focus on zoonotic disease surveillance and the implementation of preventive measures, such as vaccination programs, are key trends in the North American market.

2. Europe:

Market Share: Europe is the second-largest market for Q fever, driven by several outbreaks in the past decade, particularly in countries like the Netherlands. The region has seen significant investment in research and preventive measures.

Trends: Europe is witnessing a rise in the use of vaccines and the implementation of stricter animal health regulations to curb the spread of Q fever.

3. Asia-Pacific:

Market Share: The Asia-Pacific region is expected to register the highest growth rate during the forecast period. The region's large livestock population, coupled with increasing awareness and healthcare access, drives market expansion.

Trends: The growing focus on animal health and zoonotic disease prevention in countries like China and India is expected to boost demand for Q fever diagnostics and vaccines.

4. Latin America and Middle East & Africa:

Market Share: These regions account for a smaller market share but offer significant growth potential due to improving healthcare infrastructure and increasing awareness of zoonotic diseases like Q fever.

Trends: The growing focus on expanding access to affordable healthcare and vaccines in these regions is likely to drive market growth.

Industry Trends

1. Increasing Awareness and Surveillance:

The rising awareness of zoonotic diseases and their potential impact on public health is driving increased surveillance and reporting of Q fever cases. Governments and health organizations are investing in educational campaigns and monitoring programs to control the spread of the disease.

2. Advances in Diagnostic Technologies:

Ongoing advancements in diagnostic technologies, such as PCR and serological tests, are improving the accuracy and speed of Q fever diagnosis. These innovations are crucial in identifying outbreaks early and implementing appropriate control measures.

3. Growing Focus on Vaccination:

Vaccination is emerging as a key strategy in preventing Q fever, particularly in high-risk populations. Governments in endemic regions are increasingly adopting vaccination programs to protect both humans and livestock from the disease.

4. Impact of Climate Change:

Climate change is expected to influence the distribution and incidence of Q fever, as it affects the habitats of animal reservoirs and vectors. This is leading to a growing emphasis on research and surveillance to predict and mitigate the impact of climate change on Q fever epidemiology.

5. Regulatory Challenges:

The regulation of Q fever vaccines and treatments is a critical aspect of the market. Stringent regulatory guidelines ensure the safety and efficacy of these products, but they also pose challenges for manufacturers in terms of compliance and approval processes.

6. Competitive Landscape:

The Q fever market is competitive, with key players including companies like IDEXX Laboratories, Zoetis, Merck & Co., Boehringer Ingelheim, Bavarian Nordic. These companies are focusing on expanding their product portfolios, investing in research and development, and entering emerging markets to drive growth.

Forecast Through 2032

The global Q fever market is poised for significant growth through 2032, driven by the increasing prevalence of zoonotic diseases, advancements in diagnostic technologies, and the growing emphasis on vaccination. While North America and Europe will continue to dominate the market, the Asia-Pacific region is expected to emerge as a major growth area due to its large livestock population and improving healthcare infrastructure.

In conclusion, the Q fever market presents numerous opportunities for growth, particularly in emerging markets. Companies operating in this space should focus on innovation, regulatory compliance, and strategic partnerships to capitalize on the increasing global demand for effective Q fever diagnostics, treatments, and preventive measures.

[goatvetoz]

Goats were the main source of Qfever outbreaks in people in Spain.

[innerkingwolf]

Comprehensive Guide to Q Fever: Symptoms, Transmission, Prevention, and Animal Infection

Q fever, caused by the bacterium Coxiella burnetii, is a zoonotic infectious disease that poses a risk to both animals and humans. This blog explores the symptoms, transmission, risk factors, prevention strategies, diagnosis, and treatment of Q fever. Symptoms:Individuals infected with Q fever may exhibit flu-like symptoms such as fever, chills, fatigue, and muscle pain. Severe cases can lead to…

[antoniodatsch]

Documentos expõem experimentos biológicos dos EUA em soldados aliados na Ucrânia e na Geórgia - Dilyana.bg



Documentos expõem experiências biológicas dos EUA em soldados aliados na Ucrânia e na Geórgia

Por

 Dilyana Gaytandzhieva

-

24 de janeiro de 2022

33

277876

O programa da Agência de Redução de Ameaças de Defesa dos EUA (DTRA) na República da Geórgia. Foto: Ministério de Assuntos Internos da Geórgia

Enquanto os EUA planeiam aumentar a sua presença militar na Europa de Leste para “proteger os seus aliados contra a Rússia”, documentos internos mostram o que significa “protecção” americana em termos práticos.

O Pentágono conduziu experiências biológicas com resultados potencialmente letais em 4.400 soldados na Ucrânia e 1.000 soldados na Geórgia. De acordo com documentos vazados, todas as mortes de voluntários deveriam ser comunicadas dentro de 24 horas (na Ucrânia) e 48 horas (na Geórgia).

Ambos os países são considerados os parceiros mais leais dos EUA na região, com uma série de programas do Pentágono a serem implementados no seu território. Um deles é o programa de engajamento biológico da Agência de Redução de Ameaças de Defesa (DTRA), de US$ 2,5 bilhões, que inclui pesquisas sobre bioagentes, vírus mortais e bactérias resistentes a antibióticos sendo estudado na população local.

Projeto GG-21: “Todas as mortes de voluntários serão prontamente comunicadas”

O Pentágono lançou um projeto de 5 anos com uma possível extensão de até 3 anos, com o codinome GG-21: “Infecções zoonóticas e transmitidas por artrópodes entre militares na Geórgia”. De acordo com a descrição do projeto, serão obtidas amostras de sangue de 1.000 recrutas militares no momento do exame físico de registro militar no hospital militar georgiano localizado em Gori.

As amostras serão testadas para anticorpos contra quatorze patógenos:

Bacillus anthracis

Brucela

Vírus CCHF

Coxiella burnetii

Francisella tularensis

Hantavírus

Espécies de Rickettsia

Vírus TBE

Espécies de Bartonella

Espécies de Borrelia

Espécies de Ehlrichia

Espécies de Leptospira

Salmonela tifo

WNV

A quantidade de sangue coletado será de 10 ml. As amostras serão armazenadas indefinidamente no NCDC (Lugar Center) ou USAMRU-G e as alíquotas poderão ser enviadas para a sede da WRAIR nos EUA para futuras pesquisas. O Instituto de Pesquisa do Exército Walter Reed (WRAIR) é o maior centro de pesquisa biomédica administrado pelo Departamento de Defesa dos EUA. Os resultados dos exames de sangue não serão fornecidos aos participantes do estudo.

Tal procedimento não pode causar a morte. No entanto, de acordo com o relatório do projeto, “todas as mortes de voluntários serão imediatamente comunicadas (geralmente dentro de 48 horas após o PI ser notificado)” ao Exército Georgiano. Hospital e WRAIR.

 

De acordo com o relatório do projeto GG-21, “todas as mortes de voluntários serão prontamente comunicadas” ao hospital militar georgiano e ao WRAIR, nos EUA.

As amostras de sangue dos soldados serão armazenadas e posteriormente testadas no Lugar Center, uma instalação financiada por 180 milhões de dólares pelo Pentágono, na capital da Geórgia, Tbilisi.

O Lugar Center tornou-se famoso nos últimos anos por atividades controversas, incidentes de laboratório demonstraram.documentos internos. A causa da morte na maioria dos casos foi listada como desconhecida, pelo menos 248 mortes de pacientes e escândalos em torno do programa de hepatite C da gigante farmacêutica norte-americana Gilead na Geórgia, que resultou em

O projeto georgiano GG-21 foi financiado pela DTRA e implementado por cientistas militares americanos de uma unidade especial do Exército dos EUA de codinome USAMRU-G que opera no Centro Lugar. Eles receberam imunidade diplomática na Geórgia para pesquisar bactérias, vírus e toxinas sem serem diplomatas. Esta unidade está subordinada ao Instituto de Pesquisa do Exército Walter Reed (WRAIR).

O Lugar Center é o biolaboratório financiado pelo Pentágono, no valor de 180 milhões de dólares, na capital da Geórgia, Tbilisi. 

...

[evoldir]

Fwd: PostDoc: ClermontFerrand_France.CoxiellaPathogenPhylogeny

Begin forwarded message: > From: evoldir@evol.biology.mcmaster.ca > Subject: PostDoc: ClermontFerrand_France.CoxiellaPathogenPhylogeny > Date: 21 October 2023 at 09:17:18 BST > To: rdmpage@gmail.com > > > We are recruiting a postdoc to join our group on the epidemiology of > animal and zoonotic diseases (epia.clermont.hub.inrae.fr) to work in > the fields of bacterial genomics, phylogenetics, disease ecology and > epidemiology. > > The position is funded by Q-Net-Assess (Improved molecular surveillance > and assessment of host adaptation and virulence of Coxiella burnetii > in Europe), an ICRAD European research program on Q fever, a zoonotic > disease caused by Coxiella burnetii infections. > > Your main task will be to carry out a genome-based phylogenetic study > of C. burnetii across Europe, in collaboration with partners of the > project. This would be based on ~200 bacterial genomes from different > host species and different countries. > > You will also be involved in various analyses designed to complement the > information provided by the genome-based phylogenetic analysis to explore > the factors that determine the distribution of C. burnetii lineages on > a regional scale. This involves studying the evolution of quantitative > virulence traits obtained for a subset of strains and the analysis of > bacterial genotyping data obtained at a finer scale. > > Job Offer Details: > Position: Post-doctoral researcher > Duration: 2 years > Gross salary: between 2,600€ and 3,300€ depending on experience > Location: Theix close to Clermont-Ferrand, France > Starting Date: as soon as possible (before April 2024) > > Applications before Novembre 7, 2023 > > Please send an email to elsa.jourdain@inrae.fr, xavier.bailly@inrae.fr > and julien.theze@inrae.fr with : > - a cover letter detailing your research interests, relevant experience, >  and motivation for the position. > - a curriculum vitae with a list of publications and contact information >  of two professional references > > Please feel free to contact us for any inquiries regarding the position > or the application process. > > Xavier Bailly

[nklminhnguyen262]

Bệnh sốt Q là gì và có nguy hiểm không?

Bệnh sốt Q là gì và có nguy hiểm không?

Bệnh sốt Q, hay còn được gọi là hạch hạt (query fever), là một loại bệnh do vi khuẩn Coxiella burnetii gây ra. Vi khuẩn này có khả năng sống sót trong môi trường ngoại sinh trong thời gian dài và có thể lây nhiễm cho con người qua tiếp xúc với động vật hoặc môi trường nhiễm khuẩn.

Bệnh sốt Q có thể lây truyền từ động vật sang người thông qua tiếp xúc với phân, nước tiểu, dịch sinh dục hoặc phôi thai của động vật nhiễm khuẩn. Ngoài ra, người cũng có thể nhiễm bệnh thông qua hít phải không khí chứa vi khuẩn hoặc tiêu thụ thực phẩm nhiễm khuẩn.

Nguy hiểm của bệnh sốt Q phụ thuộc vào nhiều yếu tố, bao gồm tình trạng sức khỏe của người nhiễm khuẩn, liều lượng vi khuẩn tiếp xúc và chủng vi khuẩn. Một số trường hợp nhiễm bệnh có thể không gây ra triệu chứng hoặc chỉ có triệu chứng nhẹ, trong khi những trường hợp nghiêm trọng hơn có thể gây sốt cao, viêm phổi, viêm gan và các biến chứng khác.

Điều quan trọng là nếu bạn nghi ngờ mình có thể bị nhiễm bệnh sốt Q, bạn nên tham khảo ý kiến bác sĩ để được kiểm tra và điều trị. Nếu không được điều trị, bệnh có thể gây ra các biến chứng nghiêm trọng.

[leedsomics]

Comparative Transcriptomics and Genomics from Continuous Axenic Media Growth Identifies Coxiella burnetii Intracellular Survival Strategies

Coxiella burnetii (Cb) is an obligate intracellular pathogen in nature and the causative agent of acute Q fever as well as chronic diseases. In an effort to identify genes and proteins crucial to their normal intracellular growth lifestyle, we applied a Reverse evolution approach where the avirulent Nine Mile Phase II strain of Cb was grown for 67 passages in chemically defined ACCM-D media and gene expression patterns and genome integrity from various passages was compared to passage number one following intracellular growth. Transcriptomic analysis identified a marked downregulation of the structural components of the type 4B secretion system (T4BSS), the general secretory (sec) pathway, as well as 14 out of 118 previously identified genes encoding effector proteins. Additional downregulated pathogenicity determinants genes included several chaperones, LPS, and peptidoglycan biosynthesis. A general marked downregulation of central metabolic pathways was also observed, which was balanced by a marked upregulation of genes encoding transporters. This pattern reflected the richness of the media and diminishing anabolic and ATP-generation needs. Finally, genomic sequencing and comparative genomic analysis demonstrated an extremely low level of mutation across passages, despite the observed Cb gene expression changes following acclimation to axenic media. http://dlvr.it/Sj3Fwr

[rnewspost]

How macrophages use metabolic product to combat Q fever pathogen

Immunofluorescence microscopy of Acod1−/− BMM 120 h after infection with NMII at MOI 10. IFNγ was added or not 4 h after infection when extracellular Coxiella burnetii was removed. Staining for Lamp1 appears in green, staining for C. burnetii in pink, DAPI stain for DNA shows nuclei (examples marked by arrows) and large CCV in Acod1−/− BMM in the absence of IFNγ (marked by asterisk). Credit: EMBO…

[biogenericpublishers]

Veterinary Medicine Articles in JBGSR

Review on Q Fever: Epidemiology, Public Health Importance and Preventive Measures by Gizaw Mekonnen* in Open Access Journal of Biogeneric Science and Research (JBGSR)

Summary

Q fever is worldwide zoonotic disease which is caused by obligate intracellular gram-negative bacteria, called Coxiella burnetii. Q fever is air born disease and thus inhalation is considered as primary mode of transmission in both animal and human, sometimes through ingestion they may be infected and ticks play essential role in transmission. The agent is spread a long distance through the wind. The geographical distribution of Q fever is worldwide except New Zealand. The main reservoirs for human infections are cattle, goat, sheep, and pets and ticks are the natural primary reservoir for animal. Coxiella burnetii in ruminant cause reproductive problems like miscarriage, infertility and reduced milk production. The organism can be found in the milk, urine, feces placenta and birth fluids of animals. The airborne transmission of C. burnetii associated with its highly resistance to environments and the ability to easily produce huge quantities of C. burnetii in the after birth of aborted ewes or goats have led to classify C. burnetii as a Category-B, biological terrorism agent. The incubation period of Q fever is depending on the size of infectious. The recommended treatment for ruminant administering two injection of Oxytetracycline during the last month of gestation, also Doxycycline is the best drug. C. burnetii can be reduced in the farm environment by regular cleaning and disinfection of animal facilities. Q fever is global health problem and it is an OIE notifiable disease. Q fever is one of infectious disease which is considered as being having economic and public health importance in Ethiopia. Therefore, awareness creation and, application of prevention and control method has paramount importance in reduce the hazardous effect of this disease.

Abbreviations: SCV: Small cell variant; LCV: Large cell variant; CFSPH: Central food security public Heath; PCR: Polymerase chain reaction; LPS: Lipopolysaccharide; IFA: Indirect fluorescent antibody; OIE: Office international des Epizooties

Introduction

Q fever is a serious zoonotic disease caused by an obligate intracellular bacterium Coxiella burnetii and it is presumed to be one of the most widespread zoonosis in the world. The disease has known since the 1930s and has a worldwide distribution, with the exception of the Antarctica and possibly New Zealand [1]. The disease first identified in Queensland, Australia, in 1935, after an outbreak of febrile illness among slaughterhouse workers [2]. Some authors suggested that the Q stood of Queensland, the state in which the disease was first founds [3], but after testing all those who were affected and could not arrive at a diagnosis from the patients’ history, physical examination, and a few investigations, Derrick termed the illness “Q” for Query fever, because its etiopathogenesis was not known at the time [4]. It also known by several synonyms such as Abattoir fever, Australian Q fever, Balkan influenza, Coxiellosis, Nine-mile fever, and Pneumorickettsiosis [5].

Domestic animals such as cattle, sheep and goats are considered as the mainreservoir for the pathogen which can infect a large variety of animals, humans, birds, and arthropods [5]. Q fever is a mainly airborne zoonosis; infection is most acquired by breathing infectious aerosols or contaminated dust [6]. Infection can occur also in individuals not having direct contact with animals, such as persons living along a road used by farm vehicles or those handling contaminated clothing. The infection result from inhalation of endospores and from contact with the milk, urine, feces, vaginal mucus or semen of infected animals [7]. The pathogen is highly resistant to adverse physical conditions and chemical agents, so it can survive for months and even years in the environment which create conducive condition for infection [8].

Q fever is frequently asymptomatic, in sheep and goats it causes abortion, stillbirth, premature delivery, and delivery of weak offspring and in cattle and camel may develop infertility, metritis, and mastitis [9]. The majority of human coxiella burnetii infections are asymptomatic, especially among high-risk groups such as veterinary and slaughterhouse workers, other livestock handlers, and laboratory workers [10]. In more recent dates Q fever is classified as a “Category “B” critical biological agent” by the Centre for Diseases Control and Prevention (CDC) and is considered a potential weapon for bioterrorism [11]. The disease so is considered has having public health concern throughout the worldalongside with its economic importance. On top this, although Qfever is an OIE notifiable disease, it remains poorly reported and its surveillance is frequently severely neglected [12]. Review of the disease epidemiologic status, public health significance is lacking in different countries, including Ethiopia.

Therefore, the objectives of this seminar paper are: i. To overview Q Fevers Epidemiology, Public health importance, and preventive measures ii. To highlight current status of Q fever in Ethiopia

History of Q Fever

Q fever was first described in 1935 by Edward Holbrook Derrick [2] in abattoir workers in Brisbane, Queensland, Australia. The “Q” stands for “query” and was applied at a time when the causative agent was unknown; it was chosen over suggestions of “abattoir fever” and “Queensland rickettsial fever,” to avoid directing negative connotations at either the cattle industry or the state of Queensland [13]. Derrick inoculated guinea pigs with blood or urine from the "Q" fever patients. The guinea pigs became febrile. Derrick was unable to isolate the agent responsible for the fever so he sent a saline emulsion of infected guinea pig liver to Macfarlane Burnet in Melbourne. Burnet was able to isolate organisms, which "appeared to be of rickettsia nature" [7].

In 1936, Herald Rea Cox joined Davis at the Rocky Mountain Laboratory to additional characterize the “Nine Mile agent.” Burnet and Freeman, as well as Davis and Cox, demonstrated that the etiological agent was filterable and displayed properties of both viruses and rickettsiae. A major advance obtained in 1938, when Cox succeeded in propagating the infectious agent in embryonated eggs. Cox termed the Nine Mile Agent Rickettsia diaporica (diaporica means having the ability to pass through) a reference to the filterable property of the agent. In intervening time in Australia, Derrick suggested the name of Rickettsia burnetii for the Q fever agent. In 1948, Cornelius B. Philip proposed that R. burnetii considered as the single species of a distinct genus since it was now apparent that this organism was unique among the rickettsiae. He proposed the name Coxiella. The Q fever agent is known as Coxiella burnetii. C. burnetii, a namewhichhonors bothCox and Burnet who had identified the Q fever agent as a new rickettsial species [14]. For more Veterinary articles in JBGSR Click on https://biogenericpublishers.com/ To know more about this article click on https://biogenericpublishers.com/jbgsr.ms.id.00153.text/ https://biogenericpublishers.com/pdf/JBGSR.MS.ID.00153.pdf For Online Submissions Click on https://biogenericpublishers.com/submit-manuscript/

[mcatmemoranda]

I got mixed up between hypersensitivity pneumonitis and interstitial (atypical) pneumonia due to coxiella burnetii. I think it's because when we were taught about hypersensitivity pneumonitis, I'm pretty sure Dr. Plummer mentioned not only pigeon breeders, but also pig farmers. Or maybe I'm just confused. At any rate, veteranarians and farmers can get coxiella burnetii infection, which causes Q fever and interstitial pneumonia. Pigeon breeders can get hypersensitivity pneumonitis from inhaling the dust from the birds. Chronic hypersensitivity pneumonitis can lead to interstitial fibrosis. But this pt didn't have hypersensitivity pneumonitis. He had Q fever.

Coxiella burnetii is an obligate intracellular bacterial pathogen, and is the causative agent of Q fever. The genus Coxiella is morphologically similar to Rickettsia, but with a variety of genetic and physiological differences. C. burnetii is a small Gram-negative, coccobacillary bacterium that is highly resistant to environmental stresses such as high temperature, osmotic pressure, and ultraviolet light. These characteristics are attributed to a small cell variant form of the organism that is part of a biphasic developmental cycle, including a more metabolically and replicatively active large cell variant form. It can survive standard disinfectants, and is resistant to many other environmental changes like those presented in the phagolysosome.

This patient has likely contracted Q fever, a zoonotic infection caused by the pathogen, Coxiella burnetii. This disease has both an acute and chronic manifestation. Individuals with Q fever can present with a wide spectrum of symptoms from mild to even absent, while others present with symptoms of acute or chronic infection. An acute infection can typically present with a self limited, flu-like illness; pneumonia; hepatitis; and pyrexia of unknown origin. Chronic Q fever is an infection that lasts greater than or equal to 6 months and is more likely to occur in patients who are pregnant, immunocompromised, or have underlying valvular disease, as in this patient. In the chronic form, C. burnetii multiplies in macrophages and produces an extended bacteremia that produces high levels of antibodies, immune complexes, and autoantibodies (particularly of smooth muscle and cardiac muscle). These individuals are at high risk for developing Q fever endocarditis, which can be severe or even fatal. Q fever is more likely to occur in adult males who have contact with animals such as cattle, goats, and especially sheep. Unlike in humans, infection in animals does not cause pathologic changes in the lungs, heart, or liver. The site most often affected is the female reproductive system, primarily the placenta. So if you deal with cattle and deliver cattle, you can become exposed to C. burnetti in the placenta of the cattle.

Endocarditis, primarily of the aortic and mitral valves, is the most common manifestation of chronic Q fever. Patients who develop chronic Q fever have a weakened immune response that may allow persistence of the microorganism in the host and formation of circulating immune complexes resulting in cellular damage. As in this patient, it can also cause noncardiac manifestations including hepatomegaly, where the liver is generally hard and considerably enlarged. Most cases of chronic Q fever hepatitis are associated with endocarditis.

Bottom Line: Q fever (caused by Coxiella burnetii) is most commonly contracted through the handling of sheep placental tissue, and can cause a chronic infection that increases the risk of endocarditis, especially in immunocompromised individuals or in those with previous valvular disease.

[frontal-cortex]

Produced by the National Institute of Allergy and Infectious Diseases (NIAID), this digitally-colorized scanning electron microscopic (SEM) image of a dry-fractured Vero cell revealed its contents, and the ultrastructural details at the site of an opened vacuole, inside of which you can see numerous Coxiella burnetii bacteria undergoing rapid replication. Please see the Flickr link below for additional NIAID photomicrographs of various microbes.

Infection of humans by Coxiella burnetii bacteria usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.

Copyright Restrictions: None - This image is in the public domain and thus free of any copyright restrictions. As a matter of courtesy we request that the content provider be credited and notified in any public or private usage of this image.

[save-the-villainous-cat]

Okay. So, I’m a SUCKER for sickfics. Here’s my self-indulgent prompt:

Villain accidentally poisons Hero with a new chemical weapon they’ve been working on. It simulates a severe flu to put people out of commission for a few days. After poisoning them, they feel obligated to take care of Hero until they can survive on their own.

Preferably with quite a bit of hurt/comfort.

P.S:

Your writing never ceases to amaze me, so if you choose to use this prompt, I can’t wait to see what you come up with!

I’ve kinda been silently lurking since your 4th snippet, and it’s been awesome to see how much your followers/writing have grown over such a short period of time!

Much love,

Rin

Someone had pushed a button.

Otherwise, the villain could have never explained their own behaviour. They were terrified. They were terrified of losing them.

“What did you do to me?” the hero managed to rasp out, their arms around the villain’s neck. Those words were actually heartrending when the villain analysed them too much. They never wanted this, they never wanted the hero to look like a sick Victorian peasant who craved for a last kiss of sunshine before consumption ended them.

It was terribly obvious to the villain how fatigue and frail their hero was. Heavy limbs and an unsteady walk had been the result of the villain’s error of judgement yesterday. And now, vomiting, a bad fever and probably a lot of pain had made it to the list.

“Please, make it stop. My head…” The hero’s words turned unidentifiable when they continued to sob into the villain’s shirt.

“Okay, darling. You have to lay down now. I’ll help you. Alright?”

“No, please make it stop. Just, please,” the hero whispered, grasping the villain’s shirt.

Coxiella burnetii. That was the name, that was the bacterial pathogen the villain had experimented on. It was never meant to leave the lab, is wasn’t even supposed to escape the Petri dish.

“Darling.” The villain tried a softer approach. “You have a bacterial infection.”

But, of course, the hero had to break into the villain’s lab a week ago. Without any protection.

“I can’t lay down right now. It hurts. I want it to stop. Please make it stop.”

“Darling.” They emphasised both syllables. “I need you to get in my bed and rest.”

A whine escape the deep insides of the hero’s throat. The villain feared they would have to force their nemesis which was the last thing they wanted in this very moment but the hero didn’t protest this time. They just stayed in this position, whimpering quietly.

Right when the villain thought they had to urge the hero anew, they moved.

The hero obeyed and let the villain guide them down. When the villain helped them on the mattress, the lack of resistance was an unfamiliarity they craved to banish. They wanted the hero to be strong, they wanted them to scream at the villain, to throw an insult at them, to be angry and curse them to hell.

That would have been easier. That wouldn’t have sparked this reaction inside of the usually cold villain.

The villain tucked the hero, eyeing every movement, observing every change in their behaviour.

C. burnetii caused Q fever and the villain’s dear nemesis experienced the flu-like symptoms with a greater intensity than they had hoped they would. This wouldn’t have been that bad if the villain hadn’t experimented on the bacteria…and if the disease wasn’t able to lead to acute respiratory distress syndrom. Or in other words: the death of the hero.

“You got infected with bacteria I was working on. It uses intracellular multiplication to, well, multiply. So, it produces effector proteins to attack the host cells in your body. Those—” the villain stared at their nemesis “—fuck, why am I telling you this? You don’t need me to be nerdy.”

Just in case, the villain threw another blanket on the hero. Their own hands were trembling while they checked the hero’s forehead.

“Hurts,” the hero mumbled, frowning. The back of the villain’s hand lowered to the hero’s cheek.

The hero was a little sun of their own already — hot and seemingly pulling the villain towards them. The fever was eating through them. They had trouble breathing, there were dark circles under their eyes and they had vomited exactly twenty minutes ago. No wonder the hero’s face was buried in the villain’s pillows and their whole system longed for sleep.

The hero was someone who would go to work even with the worst illnesses. They had probably been active the whole last week, even with the infection. The hero needed sleep.

“The antibiotics should hit tomorrow. I’m sorry it takes that long.” The villain remembered how they had forced the hero to take the tetracycline yesterday when they had connected the dots between their nemesis’ symptoms and the intrusion last week. They had felt a real and strange panic attack crawling through their entire body as it dawned on them what was probably going on.

Because there was a problem with this sample of C. burnetii. A stupidly tremendous problem.

The villain had stolen it. From a biological warfare program which had been shut down a long time ago. And the villain wasn’t finished with their experiments, yet. This could be a mutant.

“Hm. You so smart,” the hero mumbled into the pillows. It sounded genuine.

“Don’t feed my ego, darling. This has punched it to a moderate level and I think I can be quite endurable, actually.” The villain sat down on the edge of the bed and rubbed their hands over their face. When they looked up, they saw how the hero nudged them. “Fuck. You should really sleep.”

[goatvetoz]

Coxiella burnetii infection persistence in a goat herd during seven kidding seasons after an outbreak of abortions.  Unfortunately there is no vaccine for goats for Qfever/Coxiella burnettii although a project looked at developing one but it is proving too difficult to make and register.  However Australia does have a disease for people which is the only country to do so.  Many livestock and pets as well as marsupials and even dust can spread Qfever.

[innerkingwolf]

Comprehensive Guide to Q Fever: Symptoms, Transmission, Prevention, and Animal Infection

Q fever, caused by the bacterium Coxiella burnetii, is a zoonotic infectious disease that poses a risk to both animals and humans. This blog explores the symptoms, transmission, risk factors, prevention strategies, diagnosis, and treatment of Q fever. Symptoms:Individuals infected with Q fever may exhibit flu-like symptoms such as fever, chills, fatigue, and muscle pain. Severe cases can lead to…