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myrawjcsmicasereports · 11 days ago

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Rapid progression of angioimmunoblastic t cell lymphoma after Covid-19 vaccination by Iryna Abramenko, MD in Journal of Clinical Case Reports Medical Images and Health Sciences

Abstract

We present the case of a 57-year-old male patient from Ukraine who developed tonsillitis and generalized lymphadenopathy approximately one week after receiving the first dose of the ChAdOx1 (AstraZeneca) anti-SARS-CoV-2 vaccine. A total body computerized tomography scan revealed pronounced lymphadenopathy above and below the diaphragm, and enlargement of the spleen. Histologic examination of the left inguinal lymph node revealed revealed lack of a clear separation of the cortical and paracortical areas. Expanded proliferation of vessels (postcapillary venules) around which atypical lymphoid cells of small and medium size were located. The most of atypical lymphoid cells expressed CD3, CD4, PD1, blc-6, and Ki-67 antigens, some cells also CD10-, CD30-positive. Diagnosis of angioimmunoblastic T-cell lymphoma (AITL), IVB Ann Arbor stage, was established. The patient received six courses of therapy CHOEP regimen. According to the results of treatment clinical and hematological remission is achieved. Thus, this article describes the second case of the development of AITL after vaccination. The accumulation of such data and their analysis will allow to make appropriate conclusions about the relationship of anti-SARS-CoV-2 vaccination with development of oncohematological diseases.

Introduction

SARS-Cov-2 virus infection is widespread throughout the world. By May 2023, the number of infected cases raised to 765,903,278 persons and a total 13,350,530,518 vaccine doses have been administered [1]. Vaccination is an effective mean of preventing infection and the development of severe forms of the disease. Eleven vaccines were recommended by World Health Organization for vaccination: Pfizer-BioNTech, Oxford-AstraZeneca, Sinopharm BIBP, Moderna, Janssen, CoronaVac, Covaxin, Novavax, CovoVax (Novavax formulation), Convidecia, Sanofi-GSK; a number of vaccines are under consideration [2]. Oxford-AstraZeneca, CoronaVac, Pfizer-BioNTech, and Moderna were used for vaccination against SARS-CoV-2 in Ukraine [3].

Vaccination leads to the development of protective antiviral immunity [4, 5]. In oncological patients, this may have ambivalent influence on tumor growth. Two cases of spontaneous tumor regression after SARS-Cov-2 vaccination have been described: shrinking of the cervical lymph node and resolution of the diffuse lung lesions in patient with a recurrent primary cutaneous anaplastic large-cell lymphoma one week after having received the first COVID-19 vaccination (BioNTech/Pfizer) [6]; and spontaneous regression of metastatic salivary gland myoepithelial carcinoma in patient one month after vaccination of mRNA-1273 COVID-19 (Moderna) vaccine [7]. Anti-cancer effect of COVID-19 vaccines (a decrease in tumor size, a decrease in the expression of tumor markers (VEGF, Ki-67, MMP-2/9), CD4/CD8 ratio, and metastasis to the vital organs) has been shown in 4T1 mice models [8].

On the other hand, cases of progression of oncohematological diseases after vaccination have also been described. Goldman et al. described rapid progression of angioimmunoblastic T cell lymphoma following BNT162b2 mRNA vaccine booster shot [9]. Cavanna et al. presented a case of anaplastic large-cell lymphoma that developed in a patient approximately 10 days after receiving the third dose of the BNT162b2 vaccine and summarized eight additional cases identified in the available literature [10]. There were four cases of diffuse large-B-cell lymphoma [11-13], one case of extranodal NK/T-cell lymphoma [12], one patient with subcutaneous panniculitis-like T-cell lymphoma [14], one case of marginal zone B-cell lymphoma [15] and one primary cutaneous anaplastic large-cell lymphoma (developed at the SARS-CoV2 vaccine injection site) [16].

In this article, we report a case of angioimmunoblastic T-cell lymphoma developed shortly after SARS-CoV2 vaccination.

Case report

The patient is a 57-year-old Caucasian man with no previous history of disease. On May 6, 2021, he received the first dose of the ChAdOx1 (AstraZeneca). A few days later, he noted a flu-like syndrome and a sore throat. A diagnosis of tonsillitis was established. Antibacterial therapy was ineffective and within two weeks patient noted rapid increase of cervical, axillary, and inguinal lymph nodes. On May, 28, 2021, trephine biopsy of the left inguinal lymph node was performed.

Pathological examination revealed lack of a clear separation of the cortical and paracortical areas. Expanded proliferation of vessels (postcapillary venules) around which atypical lymphoid cells of small and medium size were located. Mitotic figures, single plasma cells, macrophages, neutrophils and eosinophils were present. The most of atypical lymphoid cells expressed CD3, CD4, PD1, blc-6, and Ki-67 antigens, some cells also CD10-, CD30-positive. Small clusters of CD20-positive cells were found between tumor cells. CD21- and CD23-positive follicular dendritic cells wrapped around postcapillary venules. Conclusion (8.06.2021): morphological changes in the lymph node and the immunophenotype of tumor cells correspond to diagnosis of angioimmunoblastic T cell lymphoma.

CT scan (29.05.2021) revealed pronounced lymphadenopathy above and below the diaphragm (diameters of cervical lymph nodes 10-24 mm, paratracheal lymph nodes 8-18 mm, bifurcation lymph nodes 14-25 mm, right axillary lymph nodes up to 20 mm, left axillary lymph nodes up to 15 mm, inguinal lymph nodes 8-28 mm), enlargement of the spleen (5.8x12.0x11.3 cm).

On June, 11, 2021 patient referred to the hematological department of National Research Center for Radiation Medicine. Complaints of the patient upon admission: fever (up to 380C) in the second half of the day, weakness, severe fatigue, enlargement of tonsils and lymph nodes. At examination: ECOG2 performance status. Weight 72 kg. Height 174 cm. Skin is pale. Peripheral lymph nodes are palpable: submaxillary up to 6 cm, cervical 4-6 cm, axillary up to 4 cm, inguinal up to 4 cm in diameter. The liver is not enlarged. The spleen is not palpable. Breathing is vesicular. Systolic murmur over the cardiac apex. The heart rhythm is correct. Blood pressure is 115/75 mm Hg, heart rate is 80 per min. There are no edema.

Bone marrow aspiration (11.06.2021) showed hypercellular marrow, dysplasia in erythropoiesis and megakariocytopoiesis, absence of blast cells, 5.6% of lymphocytes, no cytological signs of leukemic involvement. Among all nuclear bone marrow cells 1.68% with phenotype CD45dim+CD34+CD7+CD5+CD1a-TdT- were quantified by flow cytometry.

Except high level of blood lactate dehydrogenase (1249 units/L), and C-reactive protein (29.8 mg|L) other results of laboratory test of blood and urine were unremarkable.

Diagnosis of angioimmunoblastic T-cell lymphoma (AITL), IVB Ann Arbor stage, was established, and CHOEP (cyclophosphamide, vincristine, doxorubicin, etoposide and prednisone) regimen was initiated. The patient received six courses of therapy CHOEP regimen. According to the results of treatment clinical and hematological remission is achieved: hemodynamic parameters are stable, peripheral lymph nodes are not palpable, the spleen is not enlarged, and the size of the tonsils has decreased significantly. At the time of this report the patient continues to be in clinical and hematological remission.

Discussion

The most exciting, intriguing question is: can vaccines induce the development of tumors, in particular, lymphoproliferative diseases?

So far, only the development of fibrosarcomas in cats after vaccination is known. This has been proven for killed adjuvanted virus vaccines (vaccination against rabies and feline leukemia virus). An inflammatory process with the formation of granulomatous nodules, only 5% of which subsequently undergo transformation, preceded tumor development. The interval between vaccine administration and detection of sarcoma varied from 4 months to several years [17]. In human, we found three similar cases in the literature: the development of lymphoma and undifferentiated, pleiomorphic high-grade sarcoma at the site of anti-SARS-CoV-2 vaccine administration [16, 18], and peripheral T-cell lymphoma at the injection site of influenza vaccination [19]. However, the interval between vaccine administration and tumor development was short, which does not fit into the classical scheme for the development of the oncological process (initiation, promotion, progression). Thus, it is unclear whether there is a true association between vaccination and the development of malignancy.

For the case described in this article, progression of preceding lymphoma under the influence of the vaccine seems more likely. Anti-SARS-CoV-2 vaccines cause a powerful immune response and stimulation of T- and B-lymphocytes, as well as the production of numerous cytokines [20]. Cases of post vaccine benign lymphadenopathy are described [21]. Today, AITL is recognized as a neoplasm derived from T-follicular helper cells [22, 23]. Up to 75% of AITL patients had a mutation RHOA G17V that facilitates proliferation and activation of several signaling pathways [24]. Since T-follicular helper cells are one of the main targets of mRNA vaccines [25], the Goldman et al. suggested that their stimulation under the influence of the vaccine can accelerate the development of AITL. In their case the malignant cells of patient had a mutation RHOA G17V that could make them especially sensitive to anti-SARS-CoV-2 vaccines [9]. Unfortunately, molecular genetic studies have not been performed in our patient.

Thus, this article describes the second case of the development of AITL after vaccination. The accumulation of such data and their analysis will allow to make appropriate conclusions about the relationship of anti-SARS-CoV-2 vaccination with development of oncohematological diseases. It will contribute to our better understanding of the possible negative consequences of anti-SARS-CoV-2 vaccination and their prevention as well.

#Rapid progression #t cell lymphoma #hematological remission #Journal of Clinical Case Reports Medical Images and Health Sciences quartile.#jcrmhs

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journeyjottings · 6 months ago

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Canadian Student Visa – Eligibility Criteria and Application Process

In recent years, Canada has become a sought-after destination for international students pursuing higher education via Canadian student visa. Admission into premier Canadian universities requires outstanding academic credentials while obtaining a study permit is essential for legal enrollment. The visa application process for foreign students carries a fee of CAD 150.

To pursue studies in Canada, prospective students must initiate the application process for a Temporary Resident Visa through the Canadian High Commission, which is facilitated by Visa Application Centers. Upon arrival in Canada, students are granted a study permit, a prerequisite for enrollment in Designated Learning Institutions (DLIs) as mandated by Canadian immigration authorities. Due to processing times potentially lasting up to three months, early application submission is strongly advised.

As of May 2024, international students are permitted to engage in off-campus employment for up to 24 hours per week.

Qualification Criteria and Documentation Requirements for Canadian Student Visa

To be eligible for a Canadian student visa, applicants must fulfill the following criteria:

Be fully vaccinated with approved vaccines such as AstraZeneca or Covaxin.

Receive acceptance from a DLI.

Demonstrate financial capability to cover tuition, living expenses, and return travel.

Possess a clean criminal record, subject to police verification.

Undergo a medical examination.

Convince the visa officer of their intention to depart Canada post-study.

Essential Documents for Canadian Student Visa

Valid Passport: Covering the intended duration of stay in Canada.

Acceptance Letter from a DLI: Confirmation of admission from the educational institution.

Financial Proof: Evidence of financial capacity to support tuition and living expenses.

Passport-Sized Photos: Recent photographs adhering to specified guidelines.

Immigration Medical Examination: Conducted by approved medical practitioners.

English Language Proficiency Test Score: Recommended, though not mandatory during initial application.

Statement of Purpose: An essay detailing reasons for studying in Canada.

Credit Card: Required for online payment of application fees.

Provincial Attestation Letter: Mandatory for undergraduate students or those pursuing non-degree courses.

Application Procedure

Check Processing Time: Typically six weeks, excluding biometric processing duration.

Determine Application Method: Choose between online or paper applications.

Pay Processing Fee: CAD 150, plus an additional CAD 85 for biometric processing.

Submit Application: Visit the nearest Visa Application Center (VAC) with all requisite documents.

Here’s an in-depth guide to navigating the process.

Online Application Process

Document Preparation: Ensure access to a scanner or camera for creating electronic copies of documents. A valid credit card is required for fee payment.

Fingerprint Scan Requirement: After online application submission, provide fingerprints at the regional Visa Application Centre (VAC).

Visit VFS Offices: Submit your passport and confirm the application form at VFS offices. Submit the required fee to the embassy for the Canadian study visa. Required documents at the VAC may vary slightly based on the application.

Paper Application Process

Download Application Kit: Obtain the application kit and instruction guide from the official website, containing vital information and a document checklist.

Eligibility for Paper Application: Paper application is applicable if:

Applicant faces disability preventing online application submission.

Applicant holds an identity or travel document for non-national residents, refugees, or stateless persons.

Study Finances

The minimum bank balance requirements for Canada student visa applicants are as follows:

Outside Quebec:

Primary Applicant: CAD 10,000 annually (excluding tuition fee)

First Family Member: CAD 4,000 annually

Each Additional Member: CAD 3,000 annually

In Quebec:

Single person under 18 years: CAD 6,569 annually

Single person 18 years or above: CAD 13,134 annually

Two persons 18 years or above: CAD 19,264 annually

Two persons 18 years or above, one person under 18: CAD 21,579 annually

Two persons 18 years or above, two persons under 18: CAD 23,290 annually

Study Permit Renewal

Students must apply for permit renewal at least 30 days before expiry if studies are ongoing. Spouses and dependents can accompany students on a dependent vcisa, provided proof of adequate funds. Spouses might also qualify for an unrestricted work permit.

#Canadian student visa #application process #documentation

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newshawkers · 7 months ago

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market-news-24 · 7 months ago

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Today's Current Affairs: AstraZeneca Covid Vaccine Linked To Rare Blood Clotting Disorder If you're keeping up with the latest news, you might have heard about the recent findings regarding the AstraZeneca Covid-19 vaccine. Researchers have discovered a rare but fatal blood clotting disorder known as vaccine-induced immune thrombocytopenia and thrombosis (VITT) linked to the vaccine. The vaccine, developed in collaboration with Oxford University, has been sold as Covishield in India and Vaxzevria in Europe. The discovery of VITT has raised concerns about the safety of the vaccine, with researchers identifying a dangerous blood autoantibody directed against a protein called platelet factor 4 (PF4) as the culprit. This new research has important implications for vaccine safety and development, as well as shedding light on the genetic risk factors associated with the disorder. AstraZeneca has acknowledged the rare side effect and has taken steps to address the issue, including withdrawing the vaccine from certain markets. Stay informed about the latest developments in today's current affairs to stay ahead of the curve. [ad_2] Download Latest Movies in HD Quality Downloading In 15 seconds Scroll Down to End of This Post const downloadBtn = document.getElementById('download-btn'); const timerBtn = document.getElementById('timer-btn'); const downloadLinkBtn = document.getElementById('download-link-btn'); downloadBtn.addEventListener('click', () => downloadBtn.style.display = 'none'; timerBtn.style.display = 'block'; let timeLeft = 15; const timerInterval = setInterval(() => if (timeLeft === 0) clearInterval(timerInterval); timerBtn.style.display = 'none'; downloadLinkBtn.style.display = 'inline-block'; // Add your download functionality here console.log('Download started!'); else timerBtn.textContent = `Downloading In $timeLeft seconds`; timeLeft--; , 1000); ); [ad_1] 1. What is the rare but fatal blood clotting disorder associated with AstraZeneca's Covid-19 vaccine? - A. Vaccine-induced thrombosis and thrombocytopenia - B. Vaccine-related allergic reaction - C. Vaccine-induced fever and fatigue - D. Vaccine-associated muscle pain Answer: A. Vaccine-induced thrombosis and thrombocytopenia 2. What is the name of AstraZeneca's Covid-19 vaccine in India? - A. Covaxin - B. Covishield - C. Comirnaty - D. Moderna Answer: B. Covishield 3. In a research published in the New England Journal of Medicine, what did international experts identify in the PF4 antibodies associated with blood clotting disorders? - A. Different molecular fingerprints - B. Common genetic risk factors - C. New antigen targets - D. Unique vaccine components Answer: B. Common genetic risk factors 4. What rare side effect has been linked to the AstraZeneca Covid vaccine, causing blood clots and low blood platelet count? - A. Thrombocytosis - B. Thrombosis - C. Thrombotic Thrombocytopenic Syndrome (TTS) - D. Thrombophlebitis Answer: C. Thrombotic Thrombocytopenic Syndrome (TTS) [ad_2] What is the AstraZeneca Covid-19 vaccine known as in India? The AstraZeneca's Covid-19 vaccine was named CoviShield in India. What is VITT and how is it related to the AstraZeneca vaccine? VITT stands for vaccine-induced immune thrombocytopenia and thrombosis, which is a rare but fatal blood clotting disorder. It has been found to be related to the adenovirus vector-based Oxford-AstraZeneca vaccine, sold as Covishield in India and Vaxzevria in Europe. What was found to be the reason for VITT in relation to the AstraZeneca vaccine? An unusually dangerous blood autoantibody directed against a protein termed platelet factor 4 (or PF4) was found to be the reason for VITT in relation to the AstraZeneca vaccine. What have researchers discovered in a new study regarding PF4 antibodies? Researchers in a new study have found that the PF4 antibodies in both adenovirus

infection-associated VITT and classic adenoviral vector VITT share identical molecular fingerprints or signatures. They also noted that the pathways of lethal antibody production in these disorders must be virtually identical and have similar genetic risk factors. What important clinical implications have researchers mentioned regarding their findings? Researchers have noted that the findings regarding VITT have important clinical implications for rare cases of blood clotting after adenovirus (a common cold) infections, as well as implications for vaccine development. Lessons learned from VITT can be applicable to these cases and can help improve vaccine safety. [ad_1] Download Movies Now Searching for Latest movies 20 seconds Sorry There is No Latest movies link found due to technical error. Please Try Again Later. function claimAirdrop() document.getElementById('claim-button').style.display = 'none'; document.getElementById('timer-container').style.display = 'block'; let countdownTimer = 20; const countdownInterval = setInterval(function() document.getElementById('countdown').textContent = countdownTimer; countdownTimer--; if (countdownTimer < 0) clearInterval(countdownInterval); document.getElementById('timer-container').style.display = 'none'; document.getElementById('sorry-button').style.display = 'block'; , 1000); [ad_2] Today's current affairs bring to light a concerning discovery regarding the AstraZeneca Covid-19 vaccine. Researchers have found that the vaccine may increase the risk of a rare but fatal blood clotting disorder known as vaccine-induced immune thrombocytopenia and thrombosis (VITT). This disorder, caused by an autoantibody targeting a protein called platelet factor 4 (PF4), has been linked to the adenovirus vector-based AstraZeneca vaccine, sold as Covishield in India and Vaxzevria in Europe. Further research has shown that the PF4 antibodies in VITT after adenovirus infection and in classic adenoviral vector-induced VITT share identical molecular fingerprints. This has led experts to believe that the pathways of lethal antibody production in these disorders are virtually identical. The implications of these findings extend to improving vaccine safety and understanding rare cases of blood clotting after adenovirus infections. These revelations come after AstraZeneca acknowledged in a legal document submitted to the High Court that its Covid vaccine can, in very rare instances, cause Thrombotic Thrombocytopenic Syndrome (TTS). This rare side effect has been associated with the deaths of at least 81 people in the UK, as well as a number of serious injuries. As a result, the company has voluntarily withdrawn the Marketing authorization of its Covid vaccine from Europe and other global markets. [ad_1]

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jloisse · 1 year ago

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Les employeurs australiens ont reçu l'ordre de "détruire les données de vaccination Covid qui ont été collectées sur leurs employés" dans les 30 jours. On dirait bien que c'est la fin des haricots, maintenant ils essaient de cacher tous les crimes sous le tapis....

#australia #Australie #vaccin #vaccine #vaccinations #vaccination #vaccins #effets indésirables #effets secondaires #side effects #covidー19 #covid2020 #covid #covaxin #covid vaccine

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info24sevennews-blog · 7 months ago

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#AstraZeneca #Covaxin #Covishield #CovishieldControversy

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cavenewstimes · 7 months ago

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'Safety first', says Bharat Biotech amid AstraZeneca row

NEW DELHI: Bharat Biotech on Thursday assured Covaxin ‘s safety amid debate over Astrazeneca ‘s admission that its Covid-19 vaccine , sold as Covishield in India, could cause “rare’ side effects.The vaccine company posted a statement on X, mentioning that Covaxin was the sole Covid-19 vaccine in the government’s Covid-19 immunisation programme to have conducted efficacy trials in India. The…

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chaoticbreadengineer · 8 months ago

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Multi Specialist Hospital Bangalore At Axon Speciality Hospital

About Axon Speciality Hospital In Bangalore

Axon Speciality Hospital was started in the year 2009 and has been serving people successfully in and around Indiranagar for the last 12 years under the leadership of Dr. Praveen M and Dr.Amar P. Axon Speciality Hospital has played a major role in serving people during the time of Dengue, and H1N1 outbreak and also handled the situation very professionally.

During the pandemic, corona Axon has served the community with high zeal, providing oxygen and all other medical facilities to the needy. Axon has been instrumental in vaccinating people with Covishield and Covaxin.

Axon Speciality Hospital is a multispeciality hospital in Bangalore dedicated to providing affordable and quality health care to patients. Our team of empathetic doctors and medical staff ensures each patient receives timely attention and the right medical care in the most professional and ethical manner.

Our specialists are highly qualified and well-experienced and offer recommendations considering the best interest of the patient. We believe in making your concerns ours. Our 24-hour human, medical, and infrastructural services ensure your constant comfort and quick recovery.

We ensure that from the minute you walk in through our doors; you are treated and cared for. We offer you a shoulder to lean on and an ear to talk to.

Success for us is the smile on our patient's faces as they leave our hospital.

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ednetconsultant · 8 months ago

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Some Basic Requirements that you need to know before applying for a Canada Study Visa

Canada continues to attract lots of international students in 2024 as well. Lots of students want to go to Canada from India for further education. There are lots of things that any student needs to know before applying for a Canada study visa. But as a student, you can't gather that much information so it is advised to visit Study abroad consultants in Delhi for Canada. The consultants will guide you and help you at every step, not only this they will let you know all the requirements related to the Canada study visa.

To get admission to Canada you must have excellent academic scores. The study permit will be issued at the time of the arrival in Canada. Know you want to know how Indian students can study in Canada and what are the important things any student needs to know.

What do you understand by a Canada Study Permit?

This is a type of document that is issued by the Canadian immigration government authorities and serves as permission for international students to study in Canada. Any international student can't study in Canada without this permission.

For to get your permit for Canada you need to carry some specific documents with you. while applying for a Canada visa there are lots of important things which need to be fulfilled.

For Canada study visas students need to carry the letter of introduction with the other important documents as well.

Some basic eligibility criteria for a study permit in Canada.

You need to Qualify as a fully vaccinated Traveller. In Canada, there are some accepted vaccines such as AstraZeneca/COVISHIELD, Bharat Biotech Covaxin, etc.

you need to show or you should have specific documents to show that you have adequate funds to pay your tuition fees, living expenses, return transportation for yourself, etc.

you need to show proof of your clear background with no criminal record. The student should have a police verification certificate with them.

you need to show your medical certificates as well that you don't have any major health problems.

when you get your college acceptance letter only after that you can apply for a study permit in Canada.

Apart from these, there are some valid documents which are required for the visa.

The first one is a valid passport. According to the Canadian government, your passport validity covers the intended stay In Canada. Suppose you are planning to travel to Canada for a year course in September 2022 then your passport should be valid until at least September 2024.

Acceptance letter from college and university you are going to attend.

All the proofs of funds.

Passport-size photographs.

Immigration Medical Examination Result

English Language Proficiency Exam score is very important.

Statement of purpose and credit card.

so if you are planning to study in Canada or Study in the USA consultants in Delhi, you need to consult Ednetconsultants for that. You will get proper guidance regarding your admission.

#best canada education consultants in delhi #us education consultants in delhi #study in usa consultants in delhi

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more-savi · 1 year ago

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The Vaccine War 2023 Movie

The Vaccine War 2023 Movie Review by Moreshanaya

Type Documentary & Drama Film Language Hindi OTT Platform Theatre / Disney Hotstar Director Vivek Agnihotri Producer Pallavi Joshi Genre Thriller The Vaccine War is a 2023 Hindi-language medical docudrama film directed by Vivek Agnihotri and produced by Pallavi Joshi. It highlights the efforts of scientists in making Covaxin Production during the COVID-19 pandemic in India. This movie is based on the the book 'Going Viral' by Indian Council of Medical Research Professor Balram Bhargava . It stars Nana Patekar, Pallavi Joshi, Raima Sen, Anupam Kher, Girija Oak, Nivedita Bhattacharya, Saptami Gowda and Mohan Kapoor. Vaccine War was formally released on 28 September 2023 with mixed reviews from critics. The film received praise for its performances, direction and the challenges faced by scientists during the pandemic. The story of the vaccine war is the time for the scientific community to create safe and effective vaccines to combat COVID-19. The film focuses on the work of the National Institute of Virology and the Indian Council of Medical Research, discussing the challenges faced in producing vaccines. Nana Patekar, the center of the film, plays an important role in the story. It gives an inside look at scientists' efforts to tackle the pandemic and highlights the challenges faced in creating vaccines. Overall, this is an entertaining and inspiring film that offers a different perspective on one of the biggest public health issues today. The Vaccine War 2023 Movie Trailer https://youtu.be/Y-ULaz6I9oY Frequently Asked Questions: – Can this movie be seen with family? This is a Documentary + Drama Movie and as per movie there are no bad scenes, so that we can say that this film can be seen with family. How can we watch this movie? This movie is has released on Disney Hotstar on 23rd November 2023, so if you want to watch this movie you should take a subscription of Disney Hotstar. Also Read - M3GAN Movie Star-cast Release date Story Review Read the full article

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