#Contract Research and Manufacturing Services

[octanexlabsin]

OctaneX Labs, a youthful and innovative chemistry-focused company, excels in creating advanced processes for synthesizing and manufacturing a wide array of products and compounds. Their expertise spans across the Pharma, Agro, Fine, and Specialty Chemicals industries, along with CRO and CDMO sectors. The company takes on Custom Development projects and provides Contract Research and Manufacturing Services (CRAMS) to clients worldwide. OctaneX Labs has developed numerous intermediates, including crucial raw and starting materials, making them a reliable partner for contract research synthesis in all areas of Organic and Medicinal Chemistry.

[omgakashpandit]

In the pharmaceutical industry, Contract Research and Manufacturing Services (CRAMS) is a commonly used term. These services are provided by third-party companies to the pharmaceutical industry to perform research and development, manufacturing, and other related services.

[cdmoservices]

Pharma API Manufacturing Sites & Capabilities | CDMO Company | CRO | Aurigene Pharmaceutical Services

We operate 8 API manufacturing sites. Each of these sites has a dedicated facilities associated with capacity, capability, desired market, & appropriate regulatory status.

To know more:https://www.aurigeneservices.com/services/manufacturing/sites-and-capabilities

[bishtmeenakshi]

CRAMS Revolution: Riding the Wave of Innovation in a $132.8 Billion Sector

Experience the CRAMS revolution in the $132.8 billion sector. Explore market size, segmentation, trends, and reports, along with opportunities and challenges shaping the contract research and manufacturing services industry.

[nasa]

Athletes Go for the Gold with NASA Spinoffs

NASA technology tends to find its way into the sporting world more often than you’d expect. Fitness is important to the space program because astronauts must undergo the extreme g-forces of getting into space and endure the long-term effects of weightlessness on the human body. The agency’s engineering expertise also means that items like shoes and swimsuits can be improved with NASA know-how.

As the 2024 Olympics are in full swing in Paris, here are some of the many NASA-derived technologies that have helped competitive athletes train for the games and made sure they’re properly equipped to win.

The LZR Racer reduces skin friction drag by covering more skin than traditional swimsuits. Multiple pieces of the water-resistant and extremely lightweight LZR Pulse fabric connect at ultrasonically welded seams and incorporate extremely low-profile zippers to keep viscous drag to a minimum.

Swimsuits That Don’t Drag

When the swimsuit manufacturer Speedo wanted its LZR Racer suit to have as little drag as possible, the company turned to the experts at Langley Research Center to test its materials and design. The end result was that the new suit reduced drag by 24 percent compared to the prior generation of Speedo racing suit and broke 13 world records in 2008. While the original LZR Racer is no longer used in competition due to the advantage it gave wearers, its legacy lives on in derivatives still produced to this day.

Trilion Quality Systems worked with NASA’s Glenn Research Center to adapt existing stereo photogrammetry software to work with high-speed cameras. Now the company sells the package widely, and it is used to analyze stress and strain in everything from knee implants to running shoes and more.

High-Speed Cameras for High-Speed Shoes

After space shuttle Columbia, investigators needed to see how materials reacted during recreation tests with high-speed cameras, which involved working with industry to create a system that could analyze footage filmed at 30,000 frames per second. Engineers at Adidas used this system to analyze the behavior of Olympic marathoners' feet as they hit the ground and adjusted the design of the company’s high-performance footwear based on these observations.

Martial artist Barry French holds an Impax Body Shield while former European middle-weight kickboxing champion Daryl Tyler delivers an explosive jump side kick; the force of the impact is registered precisely and shown on the display panel of the electronic box French is wearing on his belt.

One-Thousandth-of-an-Inch Punch

In the 1980s, Olympic martial artists needed a way to measure the impact of their strikes to improve training for competition. Impulse Technology reached out to Glenn Research Center to create the Impax sensor, an ultra-thin film sensor which creates a small amount of voltage when struck. The more force applied, the more voltage it generates, enabling a computerized display to show how powerful a punch or kick was.

Astronaut Sunita Williams poses while using the Interim Resistive Exercise Device on the ISS. The cylinders at the base of each side house the SpiraFlex FlexPacks that inventor Paul Francis honed under NASA contracts. They would go on to power the Bowflex Revolution and other commercial exercise equipment.

Weight Training Without the Weight

Astronauts spending long periods of time in space needed a way to maintain muscle mass without the effect of gravity, but lifting free weights doesn’t work when you’re practically weightless. An exercise machine that uses elastic resistance to provide the same benefits as weightlifting went to the space station in the year 2000. That resistance technology was commercialized into the Bowflex Revolution home exercise equipment shortly afterwards.

Want to learn more about technologies made for space and used on Earth? Check out NASA Spinoff to find products and services that wouldn’t exist without space exploration.   

Make sure to follow us on Tumblr for your regular dose of space!

[tbrcresearchreport]

The Business Research Company offers contract research and manufacturing services (crams) market research report 2023 with industry size, share, segments and market growth

[market-insider]

Pharmaceutical Contract Manufacturing And Research Services Market Negatively Impacted By COVID-19

The global pharmaceutical contract manufacturing and research services market size is expected to reach USD 395.2 billion by 2030, according to a new report by Grand View Research, Inc. It is expected to expand at a CAGR of 7.2% from 2022 to 2030. The rising investments in R&D, increasing demand for generics, and the growing aging population with various chronic diseases are responsible for market growth. However, the advent of COVID-19 led to a temporary shutdown of research and manufacturing activities of ancillary goods used for manufacturing drugs, which had impacted the supply chain and is likely to have a negative impact on the market growth.

Gain deeper insights on the market and receive your free copy with TOC now @: Pharmaceutical Contract Manufacturing And Research Services Market Report

Outsourcing allows pharmaceutical companies to focus on their core competencies such as sales and marketing rather than manufacturing and research. This is expected to have a positive impact on the market growth. However, the pharmaceutical companies practicing in-house manufacturing are increasing their investments with respect to production capabilities. This may limit the potential growth of contract manufacturing services to traditional customers, thereby hampering industrial growth.

The COVID-19 pandemic has provided new opportunities for pharmaceutical contract manufacturing and research services. Because of this pandemic, the contract service sector has switched its focus toward manufacturing and research of COVID-19 therapies and vaccines. For instance, in October 2020, CDMO Recipharm formed an agreement with Arcturus Therapeutics to support the manufacturing of its COVID-19 vaccine candidate—ARCT-021. Currently, it is in the phase 1/2 clinical trial. Similarly, in March 2022, the biotechnology company GeoVax partnered with a CRO CATO SMS to support GeoVAX in the Phase 2 trials of the COVID-19 Vaccine candidate GEO-CM04S1.

[sgiandubh]

A word on Wardpark/Cumbernauld Studios

@docsama left a comment, on S's birthday, under one of my posts and I promised her an answer with more information, as soon as I got the time. Anyway, here goes - and @docsama, sorry for the delay:

Question is: who owns the Wardpark Film and Television Studios?

The answer was quick to find, in the not-so-old specialized media:

The story begins in 2013, with an ambitious Scottish entrepreneur, Terry Thomson - this guy (courtesy of The Herald, https://www.heraldscotland.com/news/15984820.analysis-three-projects-pipeline-help-productions-make-big-picture/):

He is the owner of the Thomson Pettie Group, based in Carluke (https://www.thomsonpettie.com/about-us), which has nothing to do with cinema:

You've read that right: they are 'manufacturers of fabricated metal parts and assemblies', primarily for the national automotive industry. Yet, in 2013, Mr. Thomson agreed to rent what he described as 'a dormant industrial property' - a warehouse, to be exact - to Sony, in order to host the filming and production of OL. Thus, he became the CEO of a newly created entity, The Wardpark Film and Television Studios (https://www.hackmancapital.com/scotlands-largest-most-iconic-film-studio-acquired-by-hackman-capital-partners-and-square-mile-capital/).

By 2017, Wardpark was doing so well, that a big expansion plan was announced, with the direct support of the Scottish Government, which invested £4 million via Scottish Enterprise, its business support, advice and funding agency:

And then, in November 2021, the little engine that could was sold to those two big US investors, Hackman Capital Partners (HCP) and Square Mile Capital Management LLC (now globally rebranded as Affinius Capital). In this montage, Hackman Capital Partners brought its own confirmed film studios and media management expertise...

... while Square Mile most probably funded a sizeable portion of the acquisition, simply because this is what they do best:

Perhaps an interesting detail: HCP owns and manages both the Culver City based Sony Pictures Animation Studios' Campus and the legendary Culver Studios, now rebranded by Amazon:

Back to Scotland, Wardpark Studio's sale made just about everyone happy. Mr. Thomson kept his CEO job and look who was more than thrilled about the juicy transaction:

Currently, the studio is operated by HCP's subsidiary, The MBS Group:

That means that MBS probably manages just about everything, as far as daily management is concerned, from business operations, staffing and/or property management, to lighting and grip, trucks and generators' fleet, expendables and props. Unless I could see a contract and have a precise idea, I can just enumerate all the services they offer.

At no point in time did S and C own anything of those studios. As for the Executive Producer part, that is another discussion entirely. I could be coaxed to write something about it, if you really want to know why Those Two are EPs and what does that really, really mean - because once again, I have seen and read a LOT of bullshit in here, especially in the Desperate Housewives Disgruntled Tumblrettes' corner.

Thank you for asking. It was fun to research and write and I hope it brought more clarity to you.

[momxijinping]

There is much concern that Elon Musk’s Starlink intends to provide satellite internet coverage to the United States following the failure of its Red Sea “Operation Prosperity Guardian” alliance to curb Yemen’s pro-Palestinian front.

This conversation has gained traction since the company’s announcement on 18 September that it would launch services in Yemen after months of informal contracts with the Saudi-backed government in Aden. The timing of this announcement raised eyebrows, especially as it coincided with Israel’s terrorist attacks in Lebanon, involving exploding pagers and walkie-talkies.

[...]

The announcement that Yemen would be the first country in West Asia to have full access to its services surprised many – particularly because the US embassy in Yemen was quick to praise the move as an “achievement” that could unlock new opportunities.

[...]

The rival Sanaa government, under which most of Yemen’s population lives, was quick to warn that the Starlink project may threaten Yemen and its national security. Mohammed al-Bukhaiti, a member of Ansarallah’s political bureau, criticized the US embassy’s stance, which he says:

"Confirms the relationship between the launch of Starlink and the war launched by America on Yemen, which threatens to expand the conflict to the orbits of outer space for the first time in history."

[...]

In March, the Financial Times reported that the US and UK faced intelligence shortfalls in their Red Sea campaign, particularly around the capabilities of the Ansarallah-aligned forces’ arsenal. This intelligence gap underlined the west’s need for a reliable spy network, and Starlink’s role in this context raises serious questions.

A Reuters report revealed that SpaceX had signed secret contracts with the US Department of Defense aimed at developing a spy satellite system capable of detecting global threats in real-time.

[...]

Another concerning aspect is the involvement of Israel. Israel’s spy satellites, OFEK-13 and OFEK-14, are reportedly linked to Starlink’s satellite network. SpaceX, as a third party, may provide critical guidance and intelligence to these satellites, further enhancing Tel Aviv’s surveillance capabilities in the region. This connection between Starlink and Israeli intelligence efforts has heightened fears in Yemen that the satellite network will be used to undermine the country’s security and sovereignty.

Currently, Starlink services are available primarily in Yemeni areas controlled by the Saudi and UAE-led coalition, although roaming packages allow temporary access in other regions. This has prompted concerns about data security, privacy, and the spread of misinformation, as unrestricted satellite internet bypasses local government control.

[...]

Moreover, cybersecurity risks are particularly troubling, as the network might be exploited for dangerous purposes, including facilitating terrorist activities like bombings. The presence of a global satellite internet service that bypasses local regulations raises concerns about its potential to disrupt local internet infrastructure.

Starlink could also introduce unfair competition to local provider Yemen Net, further marginalizing the national telecom provider and hindering local development efforts.

[...]

Dr Youssef al-Hadri, a right-wing political affairs researcher, shared his views with The Cradle on the recent events in Lebanon and the ongoing electronic warfare involving the US and its allies. According to Hadri, intelligence agencies operating in areas under the control of the Sanaa government face challenges in detecting the locations of missiles, drones, and military manufacturing sites.

This shortfall became even more apparent after a major intelligence operation exposed a long-running spy cell in Yemen, with activities spanning across multiple sectors.

From the risk of espionage to the undermining of local telecom providers, the implications of Starlink’s operations extend far beyond providing internet access – they could become a vehicle for foreign influence and control.

[...]

3 Oct 2024

[agbpaints]

Name: Moth

Model: MTH-9L

Manufacturer: Ceres Metals Industries

Intro Year: 3145

Class: Light Battlemech

Cost: 4.677 mn c-bills

Weight: 30 T

Top Speed: 97.2 kph

Jump Capacity: 240 meters

Quirks: difficult to maintain, no/minimal arms, nimble jumper

In the wake of the 6th Andurian War, the Strategios of the Capellan Confederation Armed Forces determined that there was a need for a new, low cost light mech to serve as a forward observer and harassment unit in their augmented companies. While the venerable Raven remained in service, its relatively low speed and expensive suite of electronics lead to a number of costly losses during the conquest of Wallacia. To that end, specifications for a new scout were sent out for bids- the new mech had to be cheap, difficult for Free Worlds League precision energy weapons to engage with, and capable of engaging and providing support for indirect fire elements of the CCAF at a variety of ranges. Unusually, despite Hellespont Industrials, the Confederation's more seasoned light manufacturer, submitting a bid in the form of the Sunfire, Ceres Metals Industries won the contract. Their design, initially named Project GOSSAMER, was delayed several times due to production shortfalls and the discovery of a Federated Suns spy ring operating at Ceres' design bureau. Eventually the mech began full production in 3145 as the Moth.

An outwardly radical design, Ceres managed to reduce the cost of their bid significantly through the use of a number of off the shelf parts and existing research prototypes. The mech's engine was a GM 180 extralight fusion power plant, originally designed for a prototype Vindicator before the VND-4L project opted for a larger 225 power plant instead, allowing the 30 ton mech to achieve ground speeds of up to 97 kph. While this speed was deemed unacceptable for the task at hand, the mech's principle designer, Dr. Oxana Ufimtsev, opted to equip the mech with a battery of Anderson jump jets and used a novel delta design for the main hull of the mech, with very low profile arms and wide, integrated control surfaces to give the mech an unusually high glide coefficient. Together, these systems allow the Moth to leap distances similar to those achievable by the Spider, despite the mech's far less powerful engine. The cost of this innovative design is a frame with extremely cumbersome access points and systems not immediately intuitive to most mechtechs, leading to increased maintenance costs and repair times. When deployed in augmented formations alongside aerospace assets, technicians are commonly cross trained on both the unit's fighters and Moths, as the two repair schedules have been found to be similar.

The production model MTH-9L Moth uses a Moscovia light PPC as its main armament, supported by a pair of Ceres Arms model JX small pulse lasers mounted in the two weapons nacels that comprise the design's arms. Additionally, the mech carries a Diverse Optics ER small laser in the left arm and an Apple Churchill TAG system in the left, imported from Hellespont's Sian facility. Clad in 6 tons of Ceres mk III Stealth Armor, the Moth is easily capable of withstanding light fire from enemy mechs while confounding longer range sensor returns. Unfortunately, to make room for the light PPC, Ceres opted to reduce the size and ammenities of the mech's cockpit, resulting in complaints from pilots assigned to the machine for long scouting patrols.

In combat, Moths are most typically used as long range harassment units, using their stealth armor and long jump range to maintain evade enemy fire as they opportunistically engage with their TAG and light PPC. As the fight progresses, some pilots may choose to engage in more active combat, allowing the indirect elements they're supporting to remove the majority of a target'a armor before attempting to destroy vulnerable exposed components with their small lasers

The first recorded combat involving a Moth occurred on Brisbane between elements of the First Victoria Rangers and a raiding force of the Concordat Commandos. Captain Curtis Bao deployed a lance of Moths to waylay the advance of a Taurian armored colum and allow for his own heavy units and combat vehicles to position themselves in foothills east of the TDF landing site. The light mechs caught the tank company and their mech escorts by surprise, outflanking the vehicles and engaging into their weaker side armor at long range with their PPCs while painting targets for Bao's LRM carriers and Thunderbolts. Eventually, the Commandos' mechs rallied and began to engage the stealthy light lance, forcing them to withdraw, however the action blunted the Taurian advance and allowed time for the Victoria Rangers to mount a successful defense of Brisbane's capital, Badwater. The surviving Moths then saw use as city fighters, their jumping capabilities allowing them to manuever easily though the urban fabric of Badwater while their X-pulse lasers let them to brutally engage Taurian infantry.

As a new design, very few variants or operators outside the Confederation have yet to be spotted. Beyond the CCAF, a few Capellan aligned mercenary commands have been allowed to officially purchase small numbers of the design, while the allied Magistracy of Canopus has managed to acquire a number of lances of the mech through unknown sources.

While their infiltration was discovered and rooted out before the full design was finalized, MIIO operatives did manage to steal plans for the early prototypes of the Moth, which the New Avalon Institute of Science used as a test bed for re-engineered laser designs and new SRM munitions. A small production run of the design, similar but without the Capellan stealth armor, was produced by Corean Enterprises at their Augusta plant, but the AFFS appears to have abandoned adding the mech to its TO&E.

Finally, several examples of the Moth were captured by forces loyal to Alaric Ward's Star League during fighting on New Earth. The Jade Falcon remnant present immediately saw use in the design as a heavier alternative to their light Ion Sparrows. A Clantech refit of the mech has been spotted using an ER large laser in place of the PPC and a quartet of small pulse lasers in the weapons nacels.

[usafphantom2]

IMAGES: Fly the new USAF stealth bomber, the B-21 Raider

Fernando Valduga By Fernando Valduga 11/10/2023 - 15:14in Military

Photo: Matt Hartman

USAF's new B-21 “Raider” flying wing bomber made its first flight on Friday, the next step in the launch of a new fleet of nuclear-capable long-range stealth bombers built by Northrop Grumman.

The B-21 left the Northrop facility at U.S. Air Force Plant 42 in Palmdale, California, at sunrise on Friday at 6:51 a.m., offering the first improvised view of the new bomber that was developed under strict security.

The aircraft went to Edwards Air Base, California, where it will continue with the flight test phase with USAF. The flight lasted about 90 minutes.

With the Cerberus callsign, the aircraft took off eastward with an F-16 companion plane after climbing about 500 feet. The landing gear was not collected, according to videos and photos that appeared on social networks.

TAP TITLE BAR TO VIEW VIDEO☝️

U.S. Air Force leaders did not disclose the first flight of the B-21, but about three dozen aviation enthusiasts and amateur photographers gathered around Plant 42 on Friday in the hope of seeing the bomber rise to the skies.

Photo: Mike Henry

The B-21, which carries the same "flying wing" format as its predecessor, the B-2, will be able to launch conventional and nuclear weapons around the world, using long-range and in-flight refueling capabilities.

The aircraft are projected to cost approximately $550 million each in 2010 dollars, or about $750 million in current inflation-adjusted dollars. However, the USAF kept other price information confidential, “which makes it difficult to validate the proposed cost,” the Congressional Research Service said in a 2021 report.

Photo: Mike Henry

The U.S. Air Force plans to buy at least 100 planes and start replacing the B-1 and B-2 bombers. The B-1 costs about US$ 60,000 per hour to operate and the B-2 costs about US$ 65,000 per hour, according to Pentagon data.

Ann Stefanek, USAF spokesperson, said: “The B-21 Raider is in flight tests. Flight tests are a critical step in the testing campaign managed by the Air Force Test Center and the 412ª Combined Test Wings B-21 Test Force."

Photo: Mike Henry

Six test aircraft are being produced now. They are being built on the same line, using the tools, processes and technicians that will build the production aircraft.

Northrop defeated a team composed of Boeing and Lockheed Martin when it won the 2015 contract to manufacture the bomber. Engine manufacturer Pratt & Whitney, Collins Aerospace, GKN Aerospace, BAE Systems and Spirit Aerosystems are among more than 400 suppliers in 40 states.

The B-21 was publicly presented in December 2022, but the expectation around its first flight had been growing for years.

In 2019, an important Air Force general suggested that the bomber could fly as early as December 2021, but the Force subsequently postponed this date to mid-2022. In early 2022, the USAF postponed even more until 2023.

The B-21 program is in the engineering and manufacturing development phase and the first aircraft will be delivered to Ellsworth Air Force Base in North Dakota.

Northrop is calling the plane a sixth-generation aircraft due to its ability to connect to other aircraft and easily integrate future weapons into its systems architecture.

The B-21 also features surface material with low observation, more durable and stealthy, which should require less maintenance and reduce operating costs and downtime.

Tags: Military AviationNorthrop Grumman B-21 RaiderUSAF - United States Air Force / U.S. Air Force

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Fernando Valduga

Fernando Valduga

Aviation photographer and pilot since 1992, has participated in several events and air operations, such as Cruzex, AirVenture, Dayton Airshow and FIDAE. He has work published in specialized aviation magazines in Brazil and abroad. Uses Canon equipment during his photographic work in the world of aviation.

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[octanexlabsin]

OctaneX Labs is a pioneering chemical company specializing in innovative solutions for the pharmaceutical, agricultural, and fine chemical industries. We offer comprehensive services, including custom development and contract research and manufacturing (CRAMS), to meet the diverse needs of our clients. With a focus on quality, efficiency, and sustainability, we strive to be the trusted partner for businesses seeking cutting-edge chemical solutions.

[spacetimewithstuartgary]

Two new satellites added to Galileo constellation for increased resilience

The European Galileo satellite navigation system keeps growing: a new pair of satellites has joined the constellation after a journey on a Falcon 9 rocket, launched from the Kennedy Space Center in Florida on 18 September at 00:50 CEST (17 September 18:50 local time).

The 13th launch in the Galileo programme, performed by SpaceX under contract with ESA, has taken Galileo satellites number 31 and 32 (FM26 and FM32) to medium Earth orbit, extending the constellation to make it more robust and resilient. In the coming weeks, the new satellites will reach their final destination at 23 222 km, where they will be tested prior to starting operations. 

ESA Director of Navigation Javier Benedicto said, “With the deployment of these two satellites, Galileo completes its constellation as designed, reaching the required operational satellites plus one spare per orbital plane. The remaining 6 Galileo First Generation satellites are expected to be deployed in 2025 and 2026 for increased robustness and performance, solidifying the resilience and reliability of Galileo and enabling uninterrupted delivery of the world’s most precise navigation.” 

ESA, as design authority and system development prime, together with manufacturer OHB, has developed and tested 38 satellites since the conception of Galileo. All but six satellites have been launched, with the remaining ones ready to join the constellation starting next year. They will be launched in pairs by Ariane 6, ESA’s new launcher that successfully completed its inaugural flight in July. Thereafter, the first batch of Galileo Second Generation (G2) satellites, currently under development by Thales Alenia Space and Airbus Defence and Space, will also be placed in orbit by ESA’s heavy launcher. 

Galileo, onwards and upwards

2024 has been a busy year in the Galileo programme, that moves ahead at full speed. In April, the first dual launch of the year placed satellites 29 and 30 in orbit. After a successful early orbit phase and test campaign, the pair entered into service in September.  

Just a few days prior to the April launch, Galileo’s new Public Regulated Service (PRS) signals started broadcasting. This encrypted navigation service is specifically designed for authorised governmental users and sensitive applications, contributing to increase Europe’s autonomy and resilience in the critical domain of satellite navigation. 

Also in April, Galileo’s ground segment, the largest in Europe and one of the continent’s most critical infrastructures, was migrated with no user impact. This upgrade was needed in part to prepare the system for Galileo’s Second Generation, that is being built by European industry. G2 satellites will be ground-breaking with fully digital navigation payloads, electric propulsion, a more powerful navigation antenna, inter-satellite link capacity and an advanced atomic clock configuration. 

About Galileo

Galileo is currently the world’s most precise satellite navigation system, serving over four billion smartphone users around the globe since entering Open Service in 2017. All smartphones sold in the European Single Market are now guaranteed Galileo-enabled. In addition, Galileo is making a difference across the fields of rail, maritime, agriculture, financial timing services and rescue operations. 

A flagship programme of the EU, Galileo is managed and funded by the European Commission. Since its inception, ESA, as system development prime and design authority, leads the design, development and qualification of the space and ground systems, and procures launch services. ESA is also entrusted with research and development activities for the future of Galileo within the EU programme Horizon Europe. The EU Agency for the Space Programme (EUSPA) acts as the system prime for the operational system provider, ensuring exploitation and safe and secure delivery of services while overseeing market demands and application needs.  

[darkmaga-retard]

otherwise investors will take their money elsewhere

Hedley Rees

Sep 25, 2024

Trialsite News Interview from 2 years ago

About two years ago, I was interviewed by Megan Redshaw, here:

Drug Development Expert Sounds Alarm Over Rushed-to-Market COVID-19 Vaccines

The hypothesis was that Big pharma’s 40-year love affair with outsourcing everything must end, otherwise investors will take their money elsewhere.

Why—three main reasons

Pharma manufacturers divested their physical storage, logistics and distribution skills and assets to the wholesaler network. Through consolidation, this network is now dominated by three major corporations – McKesson, Cardinal, and AmerisourceBergen. Pharma manufacturers’ crucial link with the users of its products has been lost.

Outsourcing drug development and commercialization activities to Contract Research Organisations (CROs) and Contract Development and Manufacturing Organisations (CDMOs) has created a highly complex network of third-party contractors working on a fee-for-service basis. These tactical, arms-length relationships have resulted in the following:

Clinical trial sponsors and product license holders must pay cash for any innovations they may want to introduce into their products, putting a drag on innovation.

Time-to-market is in the hands of the contractor network, as lead-times are stipulated in contracts, and they are conservative, to say the least.

The high contractor switching costs and disruption involved in changing supply sources means clinical trial sponsors and product license holders become locked-in and hostage to price escalation.

Each contractor involved is a different company, and some are even in competition with each other.

Outsourcing early-stage development of drugs has resulted in:

Early-stage development deprived of the investment needed to create a sound platform on safety, efficacy, and quality.

These small companies do not have the skills, funding or critical mass required to develop new drugs.

The small companies have to depend on convincing investment analysts that they have a wonder drug, so that a big pharma company buys or partners with them - BioNTech and Moderna fit the mould.

Do investors know the issues?

I suspect the investors familiar with the outsourced model think it was always a good idea to reduce risk and save costs. They should think again.

As demand has dropped, Moderna’s supplier of the drug substance, Lonza, is going to see a big hit on its projected profits. Their investors will not be happy as orders are cancelled and profits drop - see the account of the demand drop here:

[pyramidroofingcompanyinc]

⭐️Navigating Roofing Decisions: Finding the Right Contractor for Your Home⭐️

When it comes to maintaining and enhancing the integrity of your home, the roof plays a critical role. Not only does it protect you and your family from the elements, but it also adds to the aesthetic appeal and value of your property.

 Therefore, selecting a reputable roofing contractor is crucial to ensure that your roof is installed or repaired correctly. In this article, we will discuss the importance of hiring a professional roofing contractor and provide valuable tips on how to choose the right one for your needs.

🌟Why Hire a Professional Roofing Contractor?

Roofing projects are complex and can be dangerous if not handled properly. Professional roofing contractors are trained and experienced in working on different types of roofs, using the right materials, and following safety protocols. Here are some compelling reasons to hire a professional:

✨Expertise and Experience: Professional roofing contractors bring years of experience and expertise to the job. They understand the nuances of different roofing materials and can recommend the best solutions based on your needs.

✨Quality Workmanship: A reputable contractor will ensure that the job is done right the first time, using high-quality materials and adhering to industry standards.

✨Safety: Roofing can be hazardous, especially for those without the proper training and equipment. Professional roofers are equipped to handle safety concerns and minimize risks during the project.

✨Warranty and Insurance: Most professional contractors offer warranties on their workmanship and use materials that come with manufacturer warranties. They are also insured, so you're protected in case of accidents or damage during the project.

🌸Tips for Choosing the Right Roofing Contractor

Now that we understand the importance of hiring a professional, here are some tips to help you select the right roofing contractor for your home:

🌼Look for Local Reputation: Start by looking for local roofing contractors with a solid reputation in your community. Local contractors are familiar with local building codes and regulations, and you can easily verify their reputation through references and referrals.

🌼Check Credentials: Ensure that the contractor is licensed and insured. A valid license demonstrates that they have met certain standards and qualifications. Insurance protects you from liability in case of accidents.

🌼Ask for References: Request references from the contractor and follow up with these past clients. Ask about their experience with the contractor, the quality of work, and whether the project was completed on time and within budget.

🌼Get Detailed Estimates: Obtain detailed written estimates from at least three different contractors. Compare the scope of work, materials used, project timeline, and cost breakdown. Be wary of unusually low bids, as they may indicate subpar workmanship or the use of inferior materials.

🌼Verify Manufacturer Certifications: Some roofing materials require special installation certifications. Ensure that the contractor is certified to install the specific type of roofing material you choose.

🌼Communication and Professionalism: Pay attention to how the contractor communicates with you. A professional contractor will be responsive, transparent, and willing to answer your questions.

🌼Understand the Contract: Before signing any contract, make sure you understand all the terms and conditions, including payment schedules, project timelines, and warranty details.

🌼Avoid Storm Chasers: Be cautious of contractors who show up uninvited after a storm. While some legitimate contractors may offer storm damage repair services, others may be unreliable or looking to scam homeowners.

Conclusion

Investing in a new roof or repairs is a significant decision for any homeowner. By hiring a reputable roofing contractor, you can ensure that your investment is well-protected. 

Take the time to research and choose a contractor who is qualified, experienced, and trustworthy. 

Remember, the right contractor will not only deliver quality work but also provide peace of mind knowing that your roof is in good hands. So, whether you need a roof replacement, repairs, or maintenance, follow these tips to find the best roofing contractor for your home.