#Agilent

[mariamariamare]

13. 08. 2024 || Participando dos Workshops da Agilent Technologies em Recife, no Centro Regional de Ciências Nucleares - NE. Muito conhecimento adquiro de cromatografia gasosa, espectrometria de massas e afins.

E ainda consegui uma foto com um dos nomes mais importantes da cromatografia no Brasil, o sr Celso Blatt.

[stxlabs]

Do you need a "Lab-Lift"?

Imagine the potential of a workspace optimized for efficiency and safety. Don't let outdated facilities hinder your research! A revitalized lab can unlock new levels of innovation and success. Talk to one of our lab renovation specialists today.

[pharmatechy]

Quality Control in Pharmaceutical Industry | QC in Pharma Company

The Quality Control department's major and important role is in the Pharmaceutical industry.

The main role of the quality control department in the pharma industry is to check the quality of various products, such as raw materials, in-process samples, and finished products.

Their main agenda is to analyse and control the quality of the products at all stages of the manufacturing of API or Formulations.

QC is done by the Qualitative and Quantitative analysis of specific materials as per Stanard Testing Procedures (STP) or Method of Analysis.

Generally, the QC department is divided into four sections. These are main

Raw Materials

In-process Quality Checks (IPQC)

Finished Products

Stability Studies

Raw materials:

The materials come from outside industries or suppliers and road tankers check the quality of the materials as per in-house specifications or Standard testing procedures. 

These are categorised into four parts.

General Raw materials:

These are some chemical analyses, like titrimetry, and chemical analysis methods, such as organic and inorganic acids, bases, salts, etc.

Ex: Hydrochloric acid(HCl), Sulphuric acid(H2SO4), Nitric acid(HNO3), Caustic soda(NaOH), Sodium carbonate(Na2CO3), Methanol, Toluene, Acetone, Dichloromethane etc…

Key Starting Materials (KSM):

These are the building blocks of drug intermediates or used to form the structure of compounds, APIs, or Drug substances. 

The sampling method is different from general raw materials.

These are analyzed with both chemical and instrumental analysis.

Ex: Speciality Fine Chemicals, Drug Intermediates etc.

Packing Materials:

PM is used for Products/Compound materials that are stored

Ex: Fibre drums, HDPE, LDPE drums, Polyethene bags, etc…

Hazardous Materials:

HM are harmful or affect body raw materials to handling in careful safety precautions and as per its Material Safety Data Sheets (MSDS) so vendors or suppliers give a certificate of analysis based on these are approved as per customer COAs.

Ex: Sodium Hydride(NaH), Sodium Amide(NaNH2), NaCN etc…

Some catalysts are also approved as per customer COAs

Ex: Raney-Nikel, Palladium/Carbon(Pd/C) used for Hydrogenation reaction.

In-Process samples:

Online chemical and instrumental methods analysis as per in-house specification & STPs carried out samples coming from the manufacturing blocks or production department to time to give results after the process continuously.

Finished Products:

Complete Analysis carried out as per customer or In-house or Pharmacopia specification and Standard Testing Procedures of the final products.

The analysis carried out in the Quality control department is divided into two parts. These are

Chemical Analysis Laboratory (Wet Lab)

Volumetric analysis:

Chemical labs have five types of titrimetric analysis

Acid-Base Titration Ex: Hydrochloric acid (HCl), Sodium Hydroxide (NaOH)

Argentometric titration Ex: Sodium Chloride(NaCl), Aluminum chloride (AlCl3)

Redox Titration Ex: Sodium thiosulphate, Potassium permanganate

Complexometric titration Ex: Calcium chloride (Cacl2), Magnesium (Mg) and Metals

Non-aqueous titration for Drug intermediates and APIs Ex: 2-Amino Pyridine, Isonipotic acid etc..

Gravimetric analysis:

Gravimetric analysis is the mass of an ion in a compound and is determined to find out the mass per cent of the same ion in a known quantity of a compound.

Examples 1) The amount of sulphate as barium sulphate(BaSO4) from sodium sulphate(NaSO4).

2) Content of Nickel in Raney-Nickle catalyst and Palladium in Pd/C catalyst.

Wet laboratory, some important chemical analyses are

Ex: Water content(WC), Loss on drying(LOD), Residue on ignition(ROI), Specific Optical Rotation(SOR), Wt per mL, Thin Layer Chromatography(TLC), Tapped density, Friebilty, Dissolution, Disintegration etc.

Water Analysis:

Softener water: This water is used for boiler purposes to generate steam.

Demineralized or Deionised water: This water is used for chemical analysis and process areas.

Purified water: This water is used for the manufacturing process.

Three samples are collected to be analysed to their specification (WHO) and Standard testing procedures as per scheduled.

Instrumental methods of Chemical analysis

1) Chromatography: 

Instrumental analysis to analyse quantitative and qualitative investigates analytes using the help of scientific instruments.

There are main two instrumental analyses carried out for Quality Control in the Pharmaceutical industry.

This technique separates and identifies the mixture of the compounds based on their relative affinity amounts of each compound distributed between a moving mobile phase, and a stationary phase. Mostly used instruments of Quality Control in the Pharmaceutical industry

          1) High-Performance Liquid Chromatography (HPLC)           2) Gas Chromatography (GC)

2) Spectrophotometry:

Spectroscopic techniques are to pass a beam of electromagnetic radiation onto an unknown sample and observe to find out the difference between energy levels with reference.

Most commonly used spectrophotometers of Quality Control in the Pharmaceutical industry. There are 

           1) Ultra-Violet Spectrophotometer (UVS)            2) Fourier-transform infrared spectrometer (FTIR) and NIR  3) Atomic Absorption Spectrometer (AAS) and FAS

These are the main used Research Centres for Structure elucidations and Analytical Method Development.

          1) Nuclear Magnetic Resonance Spectrometer (NMR)

          2) Mass Spectrometer (MS)

3) Thermo Gravimetric Analysis (TGA)

4) Differential Thermal Analysis (DTA)

Stability Studies:

Stability studies are conducted for a re-test or expiry or a shelf life period for the drug substance or the drug product and recommended storage conditions.

These are analysed as per protocol or stability STP based on the schedule.

           1) Hold-time stability studies            2) Long-term, Accelerated, intermediate condition studies

The quality control department follows systematic proper online documentation, Logbooks, Registers, Good Laboratory Practices (GLP) and Good Documentation Practices.

After complete analysis, documented respective analysis signed and checked authorised persons to prepare the certificate of analysis approved by the Head of the department or Designee.

Backup Electronic Data:

All electronic data stored in their servers or external hard disks are Empower network or Lab solution or Open Lab software and its data is backed up and retrieved every week by an IT person.

 Conclusion:

The Quality Control department checks each step of the product manufacturing as per specification and standard testing procedures after releasing documented data.

[impact-newswire]

Agilent customers are finding new ways to treat cancer, ensure food, water, air, and medicine quality and safety

[poleznotut]

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[internetsites]

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[keferon]

So uh. Haha. I stumbled upon this video about sea lions and immediately went "Oh this is Roddy!"

Because with their hyperactive jumpy wiggly loud behavior? And with their ability to fuck around on land? That's him

Not sure if this design gives uncanny valley or if I'm just overthinking it though. Maybe I should work on it some more but I thought I'd share the idea:)

[liorlen]

gale origin playthru from astarion’s pov or smth like that

[himbosandhardwear]

Steddie I 2.1k I different first meeting I modern au I one sided enemies to lovers I rated T

“I mean, if looking like a dyke is the goal, you're nailing it,” Steve tells Robin as she holds the phone back to showcase her date outfit. “Change the belt, I think-”

He hears a throat clear behind him and spins around to find Eddie the bar manager standing behind him, a blank face and closed off body language.

“Shit,” he mumbles. “Rob, I have to go. I'll text you after work.” He hangs up on her and stuffs his phone into his back pocket. “Sorry about that. Hi, you must be Eddie.” He holds out his hand to shake but Eddie just looks at it. He lowers it, the sting of rejection biting low in his stomach. “Um. Harvey said you just got back from a tour? That's cool.”

“Mmhmm.” He sniffs. “You're on garnish duty,” he says, cold and succinct, before turning away.

It's only Steve's third day behind the bar but he'd been slinging drinks with Rachel the night before. Barback duties are beneath him, he's got six years bartending experience. He doesn't want to complain though, not to Eddie who hated him on sight, and not during his first week.

They stay out of each other's way for the first half of the night, Steve relegated to the back, slicing limes and making the pre-mixes.

He's not used to being hated so thoroughly like this. Eddie hasn't uttered a word directly to Steve since sending him to the back, but he catches Eddie's eye a few times and it's like ice water down his back. The people-pleasing little boy in him wants to cry but he's a grown fucking man, he's not going to let this bother him. Just because he was looking forward to meeting Eddie, wanted to make a friend here, wanted to get to know the guy who managed the bar when he wasn't shredding across the country. Maybe if the owner hadn't talked Eddie up like he was the next Chris Martin…or whoever the metal equivalent of that would be. And, yeah, he'd seen the photos of Eddie, the Polaroids behind the bar of him with staff and guests, and thought he was stupid hot, with his tangled curls and the dimples, and maybe he'd had some inappropriate thoughts about his in absentia boss, and maybe he'd fantasized about flirting at the end of the night, and maybe-

Anyway, it's all good. Eddie doesn't owe him kindness or friendship or a single dimpled smile. Sometimes people just don't get along and that's okay.

“Your Fernet,” he mumbles as he sets the bottle at Eddie's elbow, head down like a dog that's used to booted feet. He feels like an idiot but Eddie's frosty demeanor feels like it's balanced on a knife's edge, like he could tip over into a blazing explosion if Steve says or does the wrong thing.

Eddie doesn't thank him, just snatches the bottle and walks away.

“You're welcome,” he snarks under his breath after Eddie's well away.

“Can I get a rum and coke?” A guy asks over the counter.

Steve hesitates. He's not welcome at the bar, Eddie has made that abundantly clear, but he wasn't hired as a barback, he's a bartender, so he smiles at the guy and starts making the drink. Eddie is busy at the other end of the bar anyway.

“You're new,” the guy says, making conversation as Steve works.

“Yeah, it's my first week.”

“You liking it so far?”

Steve glances down the bar, watching Eddie shake a cocktail like he's fucking Tom Cruise or something. His face lights up at something the woman he's talking to says and the crack of his laugh travels the length of the bar, punching Steve right in the stomach. His dimples are really something to see in motion.

“Jesus Christ, I wanna wrap you in tinsel.”

Steve whips his head back around. “Huh?”

The guy chuckles. “Because you're pining so hard. Get it? Pine-ing.”

Well shit. He deflates. “That obvious, huh?”

The guy accepts his drink with a shrug. “Maybe not to everyone but to a…certain demographic…” He gives Steve a little limp wristed wave, which makes Steve crack a laugh.

“I'm Steve, by the way,” he holds out his hand, which the guy takes easily, unlike some people.

“Cary, like Cary Grant.”

“Or Cary Elwes.”

“Exactly.” He leans a ways over the bar and mumbles, “Don't look but your boy is watching us.”

Steve forces his body to not stiffen up. “Does he look mad?”

“No. Confused if anything. Pretend like I just said the funniest thing you've ever heard.”

Steve, always down for shenanigans, tips his head back and fakes the loudest howl he can without being too over the top.

“Oh, you're good. He's got his eye on you, doll. Make the most of it.”

Steve leans into the shared space, eyes half-lidded. “I hope he's seething with jealousy. He could've had me six ways from Sunday but instead he decided to hate my guts at first sight.”

“What an absolute dumbass.” Cary reaches up and taps Steve's collarbone. “If I wasn't already taken, and you weren't pining like a Christmas tree, we could've ridden into the sunset together.”

“If only,” Steve agrees with a soft laugh.

“We're out of Matcha.”

Steve jumps out of his skin. Eddie is standing three inches from Steve's side, eyes burning into him like he just caught Steve keying his car.

“Make your own Matcha,” Cary snarks, “Steve and I are getting to know one another.”

Without breaking eye contact with Steve, he growls, “I think Tony, your fiance, would prefer it if Steve made the Matcha.”

Chills run down Steve's back and arms but he maintains composure. “On it, boss.”

He slips out from under Eddie's gaze, finger waving to Cary on his way back to the kitchen. He can hear Eddie chastising but he chooses to ignore him in favor of hyperventilating in the walk-in.

“What the fuck.”

Eyes like black flames, licking up the side of Steve's neck. Collarbones raising and lowering in the light of the bar as his chest moved with each breath. Hands clenched at his sides, white knuckled.

That wasn't cold at all.

He moves on autopilot for the rest of his shift. Eddie doesn't talk to him again but Steve can feel his eyes on the back of his neck, raising the hairs and keeping him from forgetting Eddie’s existence.

Towards the end of his shift, just before midnight, he hears Robin calling his name from the bar. He comes out of the kitchen, happy to see her waving him over, excited to introduce her date. He probably shouldn't encourage this behavior, it's his first week after all, but the restaurant is closing and the bar is empty.

“Hey, you must be Chrissy,” he greets the petite woman at Robin's side, takes her tiny hand in his and gives it a firm shake. “Pleasure to meet you.”

“Same! I couldn't believe it when Robin said you'd just started here. Like, it's a crazy coincidence.”

He cocks his head but before he can ask, Eddie comes bounding over from the other side of the bar and lifts Chrissy up off her stool, swinging her in a circle while she shrieks with laughter.

“Apparently Eddie is her best friend,” Rob fills him in, sort of unnecessary at this point. Steve wouldn't have been able to imagine Eddie looking so happy, he'd been so sour faced all night. Even when he'd been laughing with the customer earlier, it was only a fraction of this.

“Tell me everything,” Chrissy is saying after he puts her down. “Last I heard you loved Cleveland and hated Boston, which I maintain is insane.”

“And I maintain you didn't have to navigate the Boston roadways with Boston drivers,” Eddie argues, still grinning. “But it was great. Exhausting but…yeah, fucking awesome.”

“I'm so proud of you, Eds. You deserve it.”

He actually fucking blushes, which is devastating to Steve's crush. Just devastating.

“Shut up,” he mumbles. “Oh, sorry, you must be Robin. Thanks for bringing Chris to see me.” He shakes her hand, not hating her on sight, Steve notes.

“No problem, but I didn't, she brought me here to see the Dingus.” At Eddie's confused look she throws a thumb back at Steve, who waves.

“Yeah, hi. Your best friend is dating my best friend. Sorry. Guess that means you're stuck with me.”

His frown doesn't abate with this explanation.

“Because they're lesbians. She's gonna have me helping her move into Chrissy’s place in, like, a week.”

“Shut up!” Robin reaches across the bar to slap the shit out of his arm and then tosses a lemon wedge at him when he jumps back out of swinging range. Chrissy giggles at them.

“Knock it off, I worked hard on those.” He picks the wedge up off the floor and tosses it into the trash. Three points.

When he looks back up, Eddie is staring at him, wide eyed.

“Oh.”

“Oh?” Steve questions.

“Ohhh.” He presses his wrists into his eye sockets.

Steve looks at Robin and Chrissy in confusion but they're both as lost as him.

“I'm an asshole.” He hasn't removed his hands yet.

“Yes,” Chrissy agrees immediately, “what did you do, Eddie?”

He finally looks up at Steve, who takes a step back, involuntarily. They stare at one another for thirty seconds. Or two days. He's not sure.

“Eddie?” Chrissy prompts again.

“I-” He turns around and walks away.

Chrissy rushes after him and yanks him back. They get into a tug match, which Chrissy wins, somehow.

“I love her,” Robin mumbles.

“I fucking said. Less than a week.”

She slides a look his way, one that reads ‘Like you're any better.’ He shouldn't have told her about his plan to seduce his boss, who he hadn't even met yet.

“Whatever you did, you apologize right now,” Chrissy commands to a pouting Eddie.

Steve stands there, eyebrows up, as Eddie grumbles an apology that would do an eleven year old Dustin proud.

“What is happening right now?” He wonders aloud.

Eddie folds his arms across his chest, his black button down stretching across his shoulders beautifully. “I heard your conversation with Robin earlier. You said something about her looking like a dyke and…I made an assumption on the kind of person you were. And I was an asshole to you because of it. I'm sorry.”

“Oh,” Steve whispers in understanding. A weight lifts off his chest. “Fuck. That's hilarious.” He can't stop the giggles from erupting.

“Okay, in my defense, most straight guys don’t get a pass.”

Steve and Robin look at each other and crack up. He wants to ask what Eddie thinks was going on with Cary if he assumed Steve was straight but Robin shrieks, “You think I would hang out with a straight man!”

“Hey! You did hang out with me when I thought I was straight!”

She shakes her head like a smug asshole. “Debatable. You've always been a lil fruity. Tommy H? Whatever that was with Billy? C'mon.”

Steve takes a turn at slapping her. When he looks back up, he finds Eddie looking at him like a kid who just found coal in his stocking, dark eyes wet and bottom lip desperately trying not to pout.

“Holy shit, stop making that face,” Steve begs.

“I can't.”

Chrissy leans up on her knees, wobbling precariously on the stool, to physically push his lip back where it belongs. He smacks her hand away and then puts his own back up to his eyes, pushing hard.

“This is divine punishment. The universe sensed I was too happy so they sent you to test me. Big fat F, just like always,” he mumbles, nonsensically.

Steve looks to Chrissy to translate.

She puts a finger to her chin, looks between the two of them, and then concludes, “He thinks you're hot and that he ruined his chances by being a prick.”

“Chrissy!” Eddie's shriek puts Robin's to shame.

But he's not denying it.

Steve makes extremely pointed eye contact with Robin and says, “It's getting late. Eddie and I have to close the bar. You should see Chrissy home.”

She nods, slow and then quick, as the message lands.

“Yes! Yes, let's get going. Leave these guys to…close the bar.”

Smooth.

They giggle the entire way out the door but Steve ignores them. Eddie is staring again, dark eyes pinning him to the mirror behind the bar.

“I was going to ask earlier but I didn't think it was appropriate…”

Eddie swallows, throat bobbing. “Ask what?”

“What's the company policy on fraternization?”

As a former jock, Steve is thoroughly impressed by Eddie's form as he vaults the bar.

[gigizetz]

You seem to work pretty fast gigi

How long does one animatic take u?

well that depends on the animatic

I think Suffering took exactly 2 weeks, We'll Be Fine took 3 weeks (I have no idea how we'll be fine took longer than suffering) and I don't really remember how long the rest took

[stxlabs]

Do you need a "Lab Lift"?

Imagine the potential of a workspace optimized for efficiency and safety. Don't let outdated facilities hinder your research! A revitalized lab can unlock new levels of innovation and success. Talk to one of our lab renovation specialists today.

[axiondelta]

I wanted to try my hand at animation and decided some scribbly walk and run cycles would be a fun way to do it. I’ve always liked to imagine that, based on Soundwave’s body structure and the fact that he’s already a delightfully eldritch cryptid of a Cybertronian, he could walk and run on all fours with ease.

[tide-draws-stuff]

This is not a monstrous nightmare. This is a winged red lizard. This creature is cumbersome and unintelligent. It holds none of the terrifying grace and agility of a true monstrous nightmare. This bulky lizard could not run and climb and jump across an arena. It could not think about anything more than a snail. Its tail is stiff and rigid, incapable of expressing the animals intrigue or joy. Its talons are that of any generic dragon, instead of the iconic large hooks of a nightmare. Its stance is stuck low to the ground instead of the wide ranges of posture a true nightmare could take on. It angers me.

This is how a true monstrous nightmare is. Its body is large, but light. It has fluid movements and eyes that are not dead with cgi. It is agile and strong, capable of running and leaping and scaring the shit out of anyone. Its eyes are forward facing, indicating its stance at the top of its food chain. You can see the cogs turning in this animals head. Its slightly askew proportions make it expressive and interesting to watch. It is active and quick and intelligent. This animal knows and is aware of what is going on. This animal is terrifying.

Call me negative and unappreciative or whatever you want, but this:

Will always pale in comparison to this:

[tsunosagun]

someone's feeling shyyy 🤭

[horse-breed-a-day]

Horse breed of the day: Irish Cob

Height: 12-16 hh

Common coat colors: Black, bay, chestnut and buckskin

Place of origin: Ireland