#401 2022

[rabbitcruiser]

HALL Wines, St. Helena (No. 7)

The 35 foot tall Bunny Foo Foo is anything but little, and is visible from highway 29 as it leaps up from our HALL St. Helena vineyard. We are thrilled to share Lawrence Argent's sculpture and we invite you to visit us at HALL St. Helena and discover all of the amazing new works of art on site.

“When David and Jennifer (Kathryn’s children) were little we were living in Dallas but spent at least 1 weekend a month at my family’s vineyard in Mendocino. One of our daily routines was to walk through the vineyard singing the song ‘Little Bunny Foo Foo hopping through the vineyard scooping up the field mice and bopping them on the head’ note that we changed the word forest to vineyard because it was our song. I am very excited that we now have a new not so little Bunny Foo Foo hopping through our vineyard here in St. Helena. Life feels like it comes full circle.” –Kathryn Hall

Biography

After seeing the incredible works of famed artist Lawrence Argent, including his Leap rabbit installation at the Sacramento Airport and his I See What You Mean piece at the Denver Convention Center, the Halls were inspired to reach out to Argent and share their story with him.

Source

[rayhaber]

İsrail Savunma Kuvvetleri'nden Albay Daxa'nın Ölümü Hakkında Açıklama

İsrail Savunma Kuvvetleri’nden Açıklama İsrail Savunma Kuvvetleri (IDF), 41 yaşındaki Albay Daxa’nın Gazze Şeridi’ndeki çatışmada hayatını kaybettiğini duyurdu. Bu trajik olay, bölgedeki gerginliğin daha da arttığı bir dönemde gerçekleşti. IDF, çatışma sırasında 401’inci Demir Raylar Tugayı’nın 52’inci taburundan bir subayın daha ağır yaralandığını bildirdi. Yaralı subayın tedavi edilmek üzere…

[justdreamsandmusic]

Summer, 2022 ; East Providence as in my Hometown, East Providence "City" Halls new rainbow bridge is something I actually thought was rather beautiful yet I couldn't help yet goof on it thinking of perspective tricks with the laptop once I decided I needed photos for myself

[elgaberino-mcoc]

spreadsheet cleanup subseries: he's more machine now than man STARR SAXON the MACHINESMITH

ComicVine: 153 issues Fandom: 103 appearances, 4 variants 0 video games

he'd merit his @MCOCwishlist spot IF he had a game or two.

exemplary candidate for a @MarvelGames debut in #MCOC

- Other Gabe

[tieflingkisser]

All unionized Dragon Age: Dreadwolf QA workers have been laid off

All of Keywords Studios’ unionized QA workers were laid off from the studio in late September after Dragon Age: Dreadwolf developer BioWare declined to continue its contract in August. The QA workers, who were contracted to assist with playtesting and quality assurance at BioWare Edmonton, won their union vote in June 2022. All 16 eligible voters said “yes” to joining United Food and Commercial Workers Canada Union, Local No. 401. It was a historic vote, making the group the first games industry union in Canada. Keywords Studios workers were in bargaining with the company when they were laid off following the news of 50 job cuts at BioWare itself. A UFCW representative told Polygon that 13 people were laid off — everyone supporting BioWare. Liz Corless, Keywords Studios’ global head of marketing, confirmed that 13 Edmonton-based QA workers were laid off.

[snoopdoggs]

#401 gifs of JANELLA SALVADOR in 'darna: season 2 (2022),' can be accessed by joining my discord server, or sending me a message off anon. janella is of filipino (cebuano) descent and was born in 1998, so cast accordingly. please like and reblog if you found these useful.

tw: violence, alcohol

please read my rules before using. all gifs were made by me, so do not redistribute or claim as your own.

[iww-gnv]

All of Keywords Studios’ unionized QA workers were laid off from the studio in late September after Dragon Age: Dreadwolf developer BioWare declined to continue its contract in August. The QA workers, who were contracted to assist with playtesting and quality assurance at BioWare Edmonton, won their union vote in June 2022. All 16 eligible voters said “yes” to joining United Food and Commercial Workers Canada Union, Local No. 401. It was a historic vote, making the group the first games industry union in Canada. Keywords Studios workers were in bargaining with the company when they were laid off following the news of 50 job cuts at BioWare itself.

[felassan]

Article: 'All unionized Dragon Age: Dreadwolf QA workers have been laid off'

The Keywords Studios workers were laid off in late September

Text:

"All of Keywords Studios’ unionized QA workers were laid off from the studio in late September after Dragon Age: Dreadwolf developer BioWare declined to continue its contract in August. The QA workers, who were contracted to assist with playtesting and quality assurance at BioWare Edmonton, won their union vote in June 2022. All 16 eligible voters said “yes” to joining United Food and Commercial Workers Canada Union, Local No. 401. It was a historic vote, making the group the first games industry union in Canada. Keywords Studios workers were in bargaining with the company when they were laid off following the news of 50 job cuts at BioWare itself. A UFCW representative told Polygon that 13 people were laid off — everyone supporting BioWare. Liz Corless, Keywords Studios’ global head of marketing, confirmed that 13 Edmonton-based QA workers were laid off. “We can confirm that regrettably the 13 Edmonton-based staff have now left the business following the end of a fixed term client contract,” Corless wrote in an email. The group of workers were laid off on Sept. 27. Russwurm added that Keywords Studios has “taken the position there is no more work available.” (Keywords Studios has several QA job postings listed on its website, in Canada and across the world. Many, but not all of these listings, are related to language localization and require specialties that the laid-off workers may not have.) Russwurm said the union filed an employment standards complaint against Keywords Studios this week. He added that Keywords Studios offered “minimal severance,” which the union is disputing. Severance has not yet been paid out, he said. (Several BioWare employees laid off at that time are currently suing the company for “adequate severance.” These are two separate issues with two separate companies, however, despite being linked to Dragon Age: Dreadwolf.) Though the unionized QA workers did not yet have a contract with Keywords Studios, they can attempt to negotiate better severance pay. Keywords Studios is headquartered in Ireland but has more than 20 worldwide offices. The studio was founded in 1998, and does not publish or develop its own games — instead, it provides art, QA, audio, and other development support for other studios, like BioWare."

[source]

(emphasis mine as there are two issues with two companies)

[jungwnies]

syn ' soobin sees that you're not really eating your food, and does his best to make sure you're healthy. pairing ' bf!soobin x gn!reader warning ' implied eating disorder, low self-esteem

401 words

“did you eat yet?” soobin asks, as he walks out from the bathroom drying his hair.

you shrug, “i’m not really hungry.”

soobin walks in front of you and reaches out for your hands, “eat with me.”

“i’m not really in the mood to eat.” you tell him, taking a deep breath.

soobin kisses the top of your head, “how about you share something with me.”

he gets up and walks over to the kitchen making a small cup of ramen. he walks back over to the couch with a ramen fresh out of the microwave and sits back down next to you. as the two of you guys wait for two minutes to take the lid off the steaming ramen, he sits a little closer to you and turns on your favorite show.

“what’s going on?” he asks, as he looks at you dearly.

you shrug, “i guess social media,” you tell him. “i just find myself comparing my features to these other people who are ten times more attractive than me and it makes me feeling disgusting.”

soobin holds your hand, “it’s all editing y/n.”

you sigh, “i know it is,” you pause. “but then i see your fans shipping you with these really pretty idols, and i don’t know, it just makes me feel like less than them.”

soobin leans his forehead against yours, “i wish i could tell the whole world who you are to me, and what you mean to me.”

you lean forward and grab the ramen and hand it to soobin, “this is a lot”

soobin takes the lid off and grabs a small bunch of the noodles and he holds it up to your mouth, “just a little piece then.”

you take a bite and smile at soobin, “i love you, thank you for understanding baby.” you tell him, kissing his cheek.

“i love you too y/n” soobin tells you, with complete adoration. “i wish you could see yourself the way i do, but all i can do is show you.”

the two of you spent the rest of the night talking, it wasn’t the most light-hearted conversation, but it wasn’t the deepest. he reminded you why you two were dating as he listened to your feelings and took care of you. there was no one else who would make you feel as loved as he does. 

2022 © jungwnies

[usedpidemo]

Update - 3rd year anniversary! (and some future plans, a reflection, etc.)

Hi everyone! π here.

By the time this post is up, it'll be the 13th of May. Three years since I began my writing journey and this Tumblr blog. Three years. Time flies by so fast. I was close to graduating senior high after it was delayed because pandemic, had my graduation in an empty room basically, now I'm hitting my third year of college. Crazy stuff.

With that said, here are the stats + timetable of the blog so far:

First work: Sandwich (Wendy) (published 05/13/21, 4:03 a.m)

Highest note count: Tell your friends (Yujin x Wonyoung) (published 01/14/23, 1274 notes)

Number of works published: 91 fics (1 fic every 12.03 days)

500 followers: June 18, 2021 (36 days)

1000 followers: October 12, 2021 (152 days)

2000 followers: June 18, 2022 (401 days)

3000 followers: November 12, 2022 (548 days)

4000 followers: May 22, 2023 (740 days)

5000 followers: December 18, 2023 (950 days)

Current follower count: 5615 (1 new follower every 5.12 days)

It's been a hectic final month of college, so I apologize for the lack of activity in recent times :< But summer is coming up very soon, so hopefully I'll have all the time in the world to write more till then! I will say, a new fic is on the near horizon, so please be on the lookout!

I would like to take the opportunity to thank every single of you, whether reader, lurker, or a fellow writer for your support! Especially during these lull times, your unwavering support has kept me afloat and has been a motivation in continuing to write. Love you guys as always. Here's to another fruitful year <3

From this point, this part will be an overall reflection and life summary of the previous year, my thoughts on some personal matters, and some ideas I've been contemplating. If you don't wanna read this, you can stop here.

I miss 2023 quite a bit, not gonna lie. I know nostalgia can quickly grow warm and fuzzy, seeing the past through rose tinted lens, but I'll admit that 2024 hasn't been off to the start I envisioned it to be. That year was mostly peak for me, and I could even argue it's my favorite year to live out based on all my experiences. Traveling to new places, finally attending live events, interacting with my K-pop biases, and so on—it really felt like the best was yet to come with how 2023 flowed and transitioned into the new year.

Five months in, and I am struggling. Horribly. Most plans, dreams, and ideas have gone up in smoke, and it's just one devastating gut punch after another. I have a shitty professor in one major that basically made me check out of that class, and I don't know my family will react when I tell them I have to repeat said class because that professor was a dick. My family's been infighting on a daily basis, and I'm mostly collateral damage to them. Not one week can go by without some serious confrontation between them. There was a brief health scare with my mother, but that seems to be a nothing matter; thank God she'll be okay.

All this just makes life so deflating, in all honesty. I get that no life is without struggle, but I genuinely don't know when we'll be in the clear. Not anytime soon, I reckon. In these tough times, there's very little comfort except the past, when everything was pretty all right for the most part. It's been demotivating to write when mom comes forward with another grievance with my sister. It's hard to write when you have a professor who likes to power trip their students into submission. It's hard when you don't know how to admit to your mother that he failed his one class because of said power tripping professor.

But that doesn't mean I will let it eat me alive. I know we've been through some utter lows in the past. And we always get back up. If no one has us, then God does.

Summer break is fast approaching and I want to fix things. Even in my own little way. I know none of what I'm saying has anything to do with writing degenerate stories about hot K-pop idols, but real life circumstances have definitely affected me more than I can brush off. I should be calm, unfazed, undeterred.

After all, some stories are meant to be finished. They just take a more unconventional route. Ask Cody.

With all that being said, I will finish these commissions over the next two months. I'm really sorry to everyone who requested and paid for their stories months and months ago; I genuinely feel bad for not getting these out on time, but I am very mindful of quality control, and I have no one to blame but myself for being a slacker and lazy worker. Despite my feelings, I should remain professional—that's what being a worker means.

A lifestyle overhaul is definitely in my list of things to improve over the summer too. Figuring out how to get writing done, finding ways to alleviate my PokeRogue addiction (GOTY), whilst having a healthy work/life balance and not losing my sanity over it. Or worse, burning out.

And I want to take this opportunity to thank all my friends—peach, caps, majorblinks, chunk, frisky, raf, c.o, levi, sins, iz, ken, v1n, ddeun, notions, kevin, eros, brandon, kaede, svn, frisky, cray, rpg, prael—for putting up with my shit for another year. This life is tough, but you guys make it tolerable. Thank you for letting me air out my grievances even when it wasn't the best time to. I pray that when everything passes, I'm able to repay you all in some shape or form generously.

And to you, dear reader, for making it this far, thank you. Whether you've been with me since day one, or day 1094, as a commenter, reposter, liking, or just passing by/lurking, thank you for giving me a chance. Without you, all of this would have been for nothing. I don't know where I would be now if I didn't take that chance, that leap of faith back in 2021, and it's because of you I am able to keep doing this for the love of the game.

With grace,

Peter / π

[3dchoujinbag]

First time Togashi posted on twitter, he was on chapter 397, page 6. It took five months from that post (May 24 - Oct 23, 2022) for chapter 391 to be published.

Today, he posted chapter 405, page 5.

He has mentioned several times that he is continuously working to find the best system to make his manga. The system for 391-400 was not as efficient as he wanted, but seemed optimistic in his 401 post. This, combined with his Sailor Moon reference about healing means he may be feeling better and/or has figured a better system.

If we just add two chapters to his previous rate, we can guess that we see Chapter 401 this November (~six months). However, depending on his current system, back pain levels, and other possible events, it could be before or after that who knows.

Other facts for the timeline I guess:

Chapter 400 was completed on November 22, 2022

Chapter 401 was completed on March 9, 2022.

In between 401 and now, he posted this "Start Over" tweet on October 1, 2023, "Start Over" being a reference to the song by Sakurazaka46, used in this official video

His father passed away in November 2023

A HxH stage play happened that he was probably involved with in some form or another

[rabbitcruiser]

HALL Wines, St. Helena (No. 6)

It starts with the vines and the land. HALL prides itself on securing the finest grapes in the Napa Valley. Roughly half of all the grapes HALL uses come from our Estate Vineyards, the other half come from vineyards from around the valley. Our viticulture team works tirelessly to seek out the best grapes available.

HALL’s estate vineyards stretch from ancient riverbeds on the valley floor to sun-drenched hilltops, encompassing approximately 150 acres of classic Bordeaux varietals. In our pursuit to craft the finest varietals possible, each HALL estate vineyard was strategically chosen for its elevation, microclimates and soil types. Director of Vineyard Operations, Don Munk, and his viticulture team, employ small-vine farming to produce low-yield, highly concentrated fruit. Each vineyard block is managed uniquely — farming practices are adjusted according to varietal, terroir, clone, rootstock, and row orientation. We farm for the highest quality fruit and employ sustainable farming practices to ensure vineyard health and optimum fruit character.

Source

[matias-2003]

The divisibility rules of every number from 2001 to 2100

2001: The number is a multiple of 3, 23 and 29 at the same time

2002: The number is a multiple of 2, 7, 11 and 13 at the same time

2003: The sum of 601 times the last digit and the rest of the number is a multiple of 2003

2004: The number is a multiple of 3, 4 and 167 at the same time

2005: The number is a multiple of 5 and 401 at the same time

2006: The number is a multiple of 2, 17 and 59 at the same time

2007: The number is a multiple of 9 and 223 at the same time

2008: The number is a multiple of 8 and 251 at the same time

2009: The number is a multiple of 41 and 49 at the same time

2010: The number is a multiple of 3, 10 and 67 at the same time

2011: The difference between 201 times the last digit and the rest of the number is a multiple of 2011

2012: The number is a multiple of 4 and 503 at the same time

2013: The number is a multiple of 3, 11 and 61 at the same time

2014: The number is a multiple of 2, 19 and 53 at the same time

2015: The number is a multiple of 5, 13 and 31 at the same time

2016: The number is a multiple of 7, 9 and 32 at the same time

2017: The difference between 605 times the last digit and the rest of the number is a multiple of 2017

2018: The number is a multiple of 2 and 1009 at the same time

2019: The number is a multiple of 3 and 673 at the same time

2020: The number is a multiple of 20 and 101 at the same time

2021: The number is a multiple of 43 and 47 at the same time

2022: The number is a multiple of 2, 3 and 337 at the same time

2023: The number is a multiple of 7 and 289 at the same time

2024: The number is a multiple of 8, 11 and 23 at the same time

2025: The number is a multiple of 25 and 81 at the same time

2026: The number is a multiple of 2 and 1013 at the same time

2027: The difference between 608 times the last digit and the rest of the number is a multiple of 2027

2028: The number is a multiple of 3, 4 and 169 at the same time

2029: The sum of 203 times the last digit and the rest of the number is a multiple of 2029

2030: The number is a multiple of 7, 10 and 29 at the same time

2031: The number is a multiple of 3 and 677 at the same time

2032: The number is a multiple of 16 and 127 at the same time

2033: The number is a multiple of 19 and 107 at the same time

2034: The number is a multiple of 2, 9 and 113 at the same time

2035: The number is a multiple of 5, 11 and 37 at the same time

2036: The number is a multiple of 4 and 509 at the same time

2037: The number is a multiple of 3, 7 and 97 at the same time

2038: The number is a multiple of 2 and 1019 at the same time

2039: The sum of 204 times the last digit and the rest of the number is a multiple of 2039

2040: The number is a multiple of 3, 17 and 40 at the same time

2041: The number is a multiple of 13 and 157 at the same time

2042: The number is a multiple of 2 and 1021 at the same time

2043: The number is a multiple of 9 and 227 at the same time

2044: The number is a multiple of 4, 7 and 73 at the same time

2045: The number is a multiple of 5 and 409 at the same time

2046: The number is a multiple of 2, 3, 11 and 31 at the same time

2047: The number is a multiple of 23 and 89 at the same time

2048: The last 11 digits are a multiple of 2048

The 10,000,000,000s digit is even and the last 10 digits are a multiple of 2048

The 10,000,000,000s digit is odd and the last 10 digits are 1024 times an odd number

2049: The number is a multiple of 3 and 683 at the same time

2050: The number is a multiple of 41 and 50 at the same time

2051: The number is a multiple of 7 and 293 at the same time

2052: The number is a multiple of 4, 19 and 27 at the same time

2053: The sum of 616 times the last digit and the rest of the number is a multiple of 2053

2054: The number is a multiple of 2, 13 and 79 at the same time

2055: The number is a multiple of 3, 5 and 137 at the same time

2056: The number is a multiple of 8 and 257 at the same time

2057: The number is a multiple of 17 and 121 at the same time

2058: The number is a multiple of 2, 3 and 343 at the same time

2059: The number is a multiple of 29 and 71 at the same time

2060: The number is a multiple of 20 and 103 at the same time

2061: The number is a multiple of 9 and 229 at the same time

2062: The number is a multiple of 2 and 1031 at the same time

2063: The sum of 619 times the last digit and the rest of the number is a multiple of 2063

2064: The number is a multiple of 3, 16 and 43 at the same time

2065: The number is a multiple of 5, 7 and 59 at the same time

2066: The number is a multiple of 2 and 1033 at the same time

2067: The number is a multiple of 3, 13 and 53 at the same time

2068: The number is a multiple of 4, 11 and 47 at the same time

2069: The sum of 207 times the last digit and the rest of the number is a multiple of 2069

2070: The number is a multiple of 9, 10 and 23 at the same time

2071: The number is a multiple of 19 and 109 at the same time

2072: The number is a multiple of 7, 8 and 37 at the same time

2073: The number is a multiple of 3 and 691 at the same time

2074: The number is a multiple of 2, 17 and 61 at the same time

2075: The number is a multiple of 25 and 83 at the same time

2076: The number is a multiple of 3, 4 and 173 at the same time

2077: The number is a multiple of 31 and 67 at the same time

2078: The number is a multiple of 2 and 1039 at the same time

2079: The number is a multiple of 7, 11 and 27 at the same time

2080: The number is a multiple of 13 and 160 at the same time

2081: The difference between 208 times the last digit and the rest of the number is a multiple of 2081

2082: The number is a multiple of 2, 3 and 347 at the same time

2083: The sum of 625 times the last digit and the rest of the number is a multiple of 2083

2084: The number is a multiple of 4 and 521 at the same time

2085: The number is a multiple of 3, 5 and 139 at the same time

2086: The number is a multiple of 2, 7 and 149 at the same time

2087: The difference between 626 times the last digit and the rest of the number is a multiple of 2087

2088: The number is a multiple of 8, 9 and 29 at the same time

2089: The sum of 209 times the last digit and the rest of the number is a multiple of 2089

2090: The number is a multiple of 10, 11 and 19 at the same time

2091: The number is a multiple of 3, 17 and 41 at the same time

2092: The number is a multiple of 4 and 523 at the same time

2093: The number is a multiple of 7, 13 and 23 at the same time

2094: The number is a multiple of 2, 3 and 349 at the same time

2095: The number is a multiple of 5 and 419 at the same time

2096: The number is a multiple of 16 and 131 at the same time

2097: The number is a multiple of 9 and 233 at the same time

2098: The number is a multiple of 2 and 1049 at the same time

2099: The sum of 210 times the last digit and the rest of the number is a multiple of 2099

2100: The number is a multiple of 3, 7 and 100 at the same time

[yasamsallik]

Karabük’te korkunç bir kara para ağı mı var ? Araştırmacı Gazeteci Ersin Eroğlu dehşeti anlattı...

Karabük'te Afrikalı öğrenci istilasının arkasında, Karabük Üniversitesi'nin ikinci, üçüncü sınıf Afrika ülkelerinde Karabük'e gelmeleri için yaptıkları sonuç garantili sınavlar var!

Lise diploması olmayanlar bile getirilmiş!

Bu sözde sınavlar; Maarif Vakfı'nın himayesinde gerçekleşiyor! Dikkatinizi çekti mi? Maarif Vakfı!

Bu olayı bir süredir zenci erkeklerle Türk kızlarının evliliğinin teşvik edilmesinden ayrı düşünmeyin!

Üniversite bahanesiyle getirilip Türkiye'de kalmaları amaçlanıyor.

İktidarın Suriyeli, Afgan ve Müslüman Afrikalılarla oluşturmaya çalıştığı ümmet toplumu projesinde görevli üniversitelerden biri Karabük Üniversitesi'dir.

Fatih Ergin.

--------------------------------------------------------------------------

malesef 😔

Bugün şunu gördüm:

Karabük Üniversitesi yabancı öğrenci sayıları:

(YÖK 2022-2023'e göre 11 bin 890)

Çad 1386

Senegal 401

Somali 493

Afganistan 348

Sudan 464

Cibuti 238

Endonezya 99

Bangladeş 32

Etiyopya 46

Fildişi Sahili C. 64

Gabon 361

Gine-Bissau 169

Moritanya 93

Kamerun 135

Kongo 149

Suriye 1498

Ürdün 464

Yemen 649

Tanzanya 53

Pakistan 139

Gana 22

Komorlar Birliği 8

Kenya 53

Mali 32

Myanmar 66

Nijer 6

Nijerya 66

Burkina Faso 11

Haiti 9

Zimbabve 4

Vasat zekalar n'olicek yurt dışında da yabancılar okuyor diyecekler. Yurt dışı bir defa zekileri alıyor kendi ülkesinde ona çalışma alanı var. Biz ne yapıyoruz. Kendi halkımızın sırtından kendi çocuklarının kontenjanından başka ülkelerin hizmetinde çalışacak çocuklar yetiştiriyoruz.

Kaldı ki Türk gençleri yurtdışında okuyamıyorlar. Kabulü ve davetiyesi olsa da vize alamıyorlar. TC vatandaşlığı el altından arap ülkeleri vatandaşlarına koşulsuz şartsız sağlandığı için Avrupalı Amerikalı Kanadalı diyor ki ne bileyim ben senin muhammad el hakeym iken muhammet haki adını almadığını.

Şimdi sağlıktan sonra yargıda da sınavsız denklik şartsız arap afrikalı hakim savcı başlarsa hiç şaşırmam

[haveyouseenthishorrormovie]

Stats from Movies 401-500

Top 10 Movies - Highest Number of Votes

The Platform (2019) had the most votes with 1,912 votes. Sauna (2008) had the least votes with 546 votes.

The 10 Most Watched Films by Percentage

Zombieland (2009) was the most watched film with 69.3% of voters out of 858 saying they had seen it.

The 10 Least Watched Films by Percentage

Slender Man (2018) was the least watched film with 71.9% of voters out of 1,354 saying they hadn’t seen it.

The 10 Most Known Films by Percentage

American Psycho (2000) was the best known film, only 1% of voters out of 1,171 saying they’d never heard of it.

The 10 Least Known Films by Percentage

Beaten to Death (2022) was the least known film, 92,86% of voters out of 658 saying they’d never heard of it.

The movies part of the statistic count and their polls below the cut.

Prey (2022) M3GAN (2022) Caveat (2020) Patchwork (2015) All Cheerleaders Die (2013) The Final (2010) Disturbing Behavior (1998) The Gate (1987) Sssssss (1973) Xtro (1982)

Body Melt (1993) Mr. Sardonicus (1961) The Abominable Dr. Phibes (1971) Eating Raoul (1982) Peeping Tom (1960) Night of the Scarecrow (1995) Bad Milo! (2013) Patrick (1978) Beaten to Death (2022) Lovely Molly (2011)

The Passenger (2023) Rent-A-Pal (2020) The Cell (2000) Faust: Love of the Damned (2000) The Children (2008) Prince of Darkness (1987) Escape Room (2019) Eraserhead (1977) Incubus (1966) Blacula (1972)

I Drink Your Blood (1971) Dementia (1955) Hollow Man (2000) Thir13en Ghosts (2001) The Endless (2017) Bite (2015) Idle Hands (1999) Undead (2003) At Midnight I'll Take Your Soul (1964) Daddy's Girl (2018)

Bad Boy Bubby (1993) Warm Bodies (2013) Resident Evil: Welcome to Raccoon City (2021) The Haunting in Connecticut (2009) The Stepford Wives (2004) Fright Night (2011) The Witches (1990) The Hills Have Eyes (2006) Cat People (1942) AVP: Alien vs. Predator (2004)

King Kong (1933) The Happening (2008) Blade (1998) Blade II (2002) Blade: Trinity (2004) Bone Tomahawk (2015) Resident Evil (2002) Don't Look Now (1973) I Know What You Did Last Summer (1997) What Lies Beneath (2000)

Sauna (2008) The Orphanage (2007) Eight Legged Freaks (2002) The Windmill Massacre (2016) Antlers (2021) Slaughterhouse Rulez (2018) Dark Signal (2016) When Evil Lurks (2023) Huesera: The Bone Woman (2022) Halloween (2018)

Halloween Kills (2021) Halloween Ends (2022) Smile (2022) Orphan (2009) Orphan: First Kill (2022) Fresh (2022) Texas Chainsaw Massacre (2022) White Noise (2005) The Platform (2019) In the Tall Grass (2019)

Slender Man (2018) It Chapter Two (2019) Annabelle (2014) The Conjuring (2013) The Nun (2018) Urban Legend (1998) Bones and All (2022) Deep Rising (1998) Black Friday (2021) Werewolf By Night (2022)

Deathgasm (2015) Slither (2006) American Psycho (2000) Friday the 13th (2009) Revenge (2017) Host (2020) A Bay of Blood (1971) Black Christmas (2019) Zombieland (2009) Zombieland: Double Tap (2019)

[covid-safer-hotties]

Preserved in our archive

A research letter from 2022 highlighting the effects of even "mild" covid on the brain.

Dear Editor,

A recent study published in Nature by Douaud and colleagues1 shows that SARS-CoV-2 infection is associated with longitudinal effects, particularly on brain structures linked to the olfactory cortex, modestly accelerated reduction in global brain volume, and enhanced cognitive decline. Thus, even mild COVID-19 can be associated with long-lasting deleterious effects on brain structure and function.

Loss of smell and taste are amongst the earliest and most common effects of SARS-CoV-2 infection. In addition, headaches, memory problems, confusion, or loss of speech and motility occur in some individuals.2 While important progress has been made in understanding SARS-CoV-2-associated neurological manifestations, the underlying mechanisms are under debate and most knowledge stems from analyses of hospitalized patients with severe COVID-19.2 Most infected individuals, however, develop mild to moderate disease and recover without hospitalization. Whether or not mild COVID-19 is associated with long-term neurological manifestations and structural changes indicative of brain damage remained largely unknown.

Douaud and co-workers examined 785 participants of the UK Biobank (www.ukbiobank.ac.uk) who underwent magnetic resonance imaging (MRI) twice with an average inter-scan interval of 3.2 years, and 401 individuals testing positive for SARS-CoV-2 infection between MRI acquisitions (Fig. 1a). Strengths of the study are the large number of samples, the availability of scans obtained before and after infection, and the multi-parametric quantitative analyses of serial MRI acquisitions.1 These comprehensive and automated analyses with a non-infected control group allowed the authors to dissect consistent brain changes caused by SARS-CoV-2 infection from pre-existing conditions. Altogether, the MRI scan processing pipeline used extracted more than 2,000 features, named imaging-derived phenotypes (IDPs), from each participant’s imaging data. Initially, the authors focused on IDPs involved in the olfactory system. In agreement with the frequent impairment of smell and taste in COVID-19, they found greater atrophy and indicators of increased tissue damage in the anterior cingulate cortex, orbitofrontal cortex and insula, as well as in the ventral striatum, amygdala, hippocampus and para-hippocampal gyrus, which are connected to the primary olfactory cortex (Fig. 1b). Taking advantage of computational models allowing to differentiate changes related to SARS-CoV-2 infection from physiological age-related brain changes (e.g. decreases of brain volume with aging),3 they also explored IDPs covering the entire brain. Although most individuals experienced only mild symptoms of COVID-19, the authors detected an accelerated reduction in whole-brain volume and more pronounced cognitive declines associated with increased atrophy of a cognitive lobule of the cerebellum (crus II) in individuals with SARS-CoV-2 infection compared to the control group. These differences remained significant when 15 people who required hospitalization were excluded. Most brain changes for IDPs were moderate (average differences between the two groups of 0.2–2.0%, largest for volume of parahippocampal gyrus and entorhinal cortex) and accelerated brain volume loss was “only” observed in 56–62% of infected participants. Nonetheless, these results strongly suggest that even clinically mild COVID-19 might induce long-term structural alterations of the brain and cognitive impairment.

The study provides unique insights into COVID-19-associated changes in brain structure. The authors took great care in appropriately matching the case and control groups, making it unlikely that observed differences are due to confounding factors, although this possibility can never be entirely excluded. The mechanisms underlying these infection-associated changes, however, remain to be clarified. Viral neurotropism and direct infection of cells of the olfactory system, neuroinflammation and lack of sensory input have been suggested as reasons for the degenerative events in olfactory-related brain structures and neurological complications.4 These mechanisms are not mutually exclusive and may synergize in causing neurodegenerative disorders as consequence of COVID-19.

The study participants became infected between March 2020 and April 2021, before the emergence of the Omicron variant of concern (VOC) that currently dominates the COVID-19 pandemic. During that time period, the Alpha and Beta VOCs dominated in the UK and all results were obtained from individuals between 51 and 81 years of age. It will be of great interest to clarify whether Omicron, that seems to be less pathogenic than other SARS-CoV-2 variants, also causes long-term brain damage. The vaccination status of the participants was not available in the study1 and it will be important to clarify whether long-term changes in brain structure also occur in vaccinated and/or younger individuals. Other important questions are whether these structural changes are reversible or permanent and may even enhance the frequency for neurodegenerative diseases that are usually age-related, such as Alzheimer’s, Parkinson’s or Huntington’s disease. Previous findings suggest that cognitive disorders improve over time after severe COVID-19;5 yet it remains to be determined whether the described brain changes will translate into symptoms later in life such as dementia. Douaud and colleagues report that none of top 10 IDPs correlated significantly with the time interval between SARS-CoV-2 infection and the 2nd MRI acquisition, suggesting that the observed abnormalities might be very long-lasting.

Currently, many restrictions and protective measures are relaxed because Omicron is highly transmissible but usually causes mild to moderate acute disease. This raises hope that SARS-CoV-2 may evolve towards reduced pathogenicity and become similar to circulating coronaviruses causing mild respiratory infections. More work needs to be done to clarify whether the current Omicron and future variants of SARS-CoV-2 may also cause lasting brain abnormalities and whether these can be prevented by vaccination or therapy. However, the finding by Douaud and colleagues1 that SARS-CoV-2 causes structural changes in the brain that may be permanent and could relate to neurological decline is of concern and illustrates that the pathogenesis of this virus is markedly different from that of circulating human coronaviruses. Further studies, to elucidate the mechanisms underlying COVID-19-associated neurological abnormalities and how to prevent or reverse them are urgently needed.

REFERENCES (Follow link)