#vinorelbine chemotherapy

[thelotusbiotech]

Raising Awareness: A Vital Step in the Fight Against Breast Cancer

Did you know that breast cancer affects millions of people worldwide each year?

Yes! Undeniably, breast cancer is a serious global health concern. Thus, understanding the data, prevalence rates, and worldwide impact sets the stage for a thorough examination of the critical role of breast cancer awareness.

Breast cancer awareness campaigns are not just symbolic but are essential to establishing a shared understanding of the disease's prevalence. Awareness catalyzes early detection, lowers death rates, and improves treatment outcomes.

Table of Content

Introduction: The Global Impact of Breast Cancer

Why is Breast Cancer Awareness So Important?

What Are Some Signs and Symptoms of Breast Cancer?

Breast Cancer Risk Factors

Breast Cancer Screening

Types of Breast Cancer

Management of Breast Cancer

Vinelbine 50mg Vinorelbine Injection: An Emerging Treatment

5 Tips for Breast Cancer Prevention

Conclusion

Why is Breast Cancer Awareness So Important?

One cannot stress the significance of raising awareness about breast cancer. It is the cornerstone of early detection and a revolutionary cancer treatment. Beyond that, breast cancer awareness programs encourage preventive actions, destigmatize discussions about the disease, and help individuals impacted by it build supportive networks.

Early Detection Impact: It greatly raises the possibility of early detection, essential for efficient therapy and higher survival rates.

Destigmatizing Conversations: It helps destigmatize breast cancer by promoting open conversations that inspire people to share their stories and look for assistance.

Promoting Prevention: Beyond diagnosis, awareness encourages preventive actions and risk factor education, enabling people to make well-informed decisions for a better way of life.

Empowering Individuals: It changes the narrative from fear to empowerment by promoting proactive participation in one's health through frequent screenings and self-examinations.

Global Impact: Breast cancer awareness is a global movement that cuts across boundaries to reach various communities, encourage early detection, and support a concerted international effort to combat the illness.

What Are Some Signs and Symptoms of Breast Cancer?

Arming people with the correct information about the signs and symptoms, including changes in breast appearance, lumps, nipple changes, and other signs, is essential to early detection. Knowing these indicators makes it possible for people to spot possible warning signs and seek prompt medical assistance.

Some Signs and Symptoms of Breast Cancer

Lump Formation: The most typical symptom is when someone feels a lump or thickening in their underarms or breasts.

Changes in Breast Appearance: Unexplained changes in the breast's size, shape, or appearance, such as dimpling, redness, or swelling.

Nipple Changes: Shifts in the position, inversion, or discharge of the nipples, mainly if bleeding or don't happen when you squeeze them.

Pain or Tenderness: Breast discomfort or soreness unrelated to the menstrual cycle or other factors.

Skin Changes: Skin changes on the breast, such as redness, scaliness, or puckering, resembling the texture of an orange peel.

Breast Cancer Risk Factors

It is vital to comprehend the diverse risk factors linked to breast cancer to practice preventative health management. This section explores lifestyle choices, reproductive history, and genetic predispositions, offering insights into how these factors affect the risk of breast cancer. Equipped with this understanding, people can employ customized preventative measures and make well-informed judgments regarding risk assessment.

Age and Gender: The two main risk factors are aging and gender; women are more susceptible to breast cancer as they get older.

Family History: An increased risk is associated with a family history of breast or ovarian cancer, particularly among first-degree relatives.

Genetic Mutations: The risk of breast cancer is greatly increased by inherited gene mutations, especially those involving BRCA1 and BRCA2.

Personal History: The risk may be raised by prior breast cancer or certain non-cancerous breast conditions.

Reproductive Factors: Contributing factors include late menopause, early menstruation, and having your first kid later in life.

Breast Cancer Screening

Early detection is a cornerstone of improved treatment outcomes. The significance of routine screenings, self-examinations, and mammography is emphasized in this section. A comprehensive manual offers advice on how people can actively participate in screening procedures and make educated decisions regarding their breast health.

Mammography: The most popular screening technique is a routine mammography, which takes pictures of the breast tissue and looks for anomalies.

Clinical Breast Exam (CBE): A physical examination is conducted by a medical professional to find lumps or textural changes in the breasts.

Breast Self-Exams: Self-examination regularly helps people get to know their breasts and recognize any changes right away.

MRI (Magnetic Resonance Imaging): Used in addition to mammography for high-risk patients or to assess ambiguous results.

Genetic Testing: Genetic testing might be advised for those with a significant family history to pinpoint specific risk factors.

Types of Breast Cancer

Breast cancer is a multifaceted illness with a range of subtypes that call for different treatment strategies. This section thoroughly reviews ductal carcinoma in situ (DCIS), invasive ductal carcinoma, and invasive lobular carcinoma. Knowledge about these subtypes increases consciousness and promotes a more sophisticated understanding of the illness.

Invasive Ductal Carcinoma (IDC): The most prevalent kind, IDC, starts in the milk ducts and spreads to the breast's surrounding tissues.

Invasive Lobular Carcinoma (ILC): It begins in the lobules, the glands that produce milk, and it spreads to the tissues around it.

Triple-Negative Breast Cancer: Lacks receptors for estrogen, progesterone, and HER2, making it more challenging to treat.

HER2-Positive Breast Cancer: Overexpression of HER2 protein makes cancer cells grow more rapidly.

Management of Breast Cancer

A multidisciplinary approach to treatment is necessary when treating breast cancer. Treatment options such as surgery, chemotherapy, radiation therapy, hormone therapy, and targeted therapies are discussed in this section. After a thorough investigation, individuals are better equipped to make educated decisions and navigate their treatment journeys.

Surgery: Removal of the tumor (lumpectomy) or the entire breast (mastectomy), depending on the severity of the disease.

Radiation Therapy: Using high-energy rays to target and eliminate cancer cells post-surgery or as an immediate treatment.

Chemotherapy: Drugs, vinelbine 50 mg, that target and eradicate cancer cells that divide quickly throughout the body.

Hormone Therapy: Typically used for tumors that are hormone receptor-positive, it blocks the hormones that cause some forms of breast cancer.

Targeted Therapy: Targets particular molecules, such as HER2, that are involved in cancer growth, offering a more targeted approach.

Vinelbine 50mg Vinorelbine Injection: An Emerging Treatment

Vinelbine 50mg Vinorelbine Injection's targeted mechanism and noteworthy benefits are altering the treatment of breast cancer:

Mechanism of Action: Vinorelbine injection is a highly potent medication against fast-dividing cells in breast cancer because it affects the microtubules of cancer cells, preventing them from growing.

Advantages: -

Efficacy: Proven efficacy when used alone or in combination with other therapies.

Tolerability: Manageable side effects improve patient compliance.

Versatility: Proven effectiveness in treating various kinds of breast cancer.

Considerations: -

Patient Profiles: Tailored according to patient profiles and according to the unique forms of breast cancer.

Combination Therapies: Frequently employed in interdisciplinary methods to improve therapeutic techniques.

Real-World Impact: -

Patient Experiences: Real-world viewpoints are provided via patient testimonies and healthcare professionals' insights.

Clinical Trials: Vinorelbine 50 mg’s prospective uses are being investigated further, helping advance treatment modalities.

Cost Considerations: The vinorelbine price may differ; people should get the correct information by contacting their insurance and healthcare providers.

Vinorelbine 50 mg, which provides a tailored and adaptable therapy strategy with the potential to enhance results, represents a substantial advancement in the treatment of breast cancer. Its function in improving breast cancer treatment is further cemented by ongoing research and practical experiences.

5 Tips for Breast Cancer Prevention

The foundation of good breast health is prevention. Beyond generic recommendations, this part offers helpful tips based on food modifications, frequent exercise, awareness of environmental influences, and lifestyle improvements. With the help of these suggestions, readers will be able to proactively lower their risk of breast cancer.

Healthy Diet: Eat a well-balanced diet that consists primarily of fruits, vegetables, and whole grains; minimize alcohol and processed foods.

Maintain a Healthy Weight: Obesity is linked to an increased risk of breast cancer, particularly after menopause.

Breastfeeding: For those who can, breastfeeding may reduce the risk of breast cancer.

Regular Check-ups: To identify any changes early on, schedule routine tests and health examinations.

Comprehending these facets is vital for prompt identification and implementation of preventive measures, augmenting efficacious breast cancer handling, and improved consequences.

Conclusion

In summary, this thorough book provides a road map for proactive health management and well-informed decision-making in breast cancer. It highlights our shared responsibility to raise awareness, encourage research, and provide people the tools they need to take control of their health, from identifying symptoms to comprehending risk factors, screening techniques, and new treatments like vinorelbine injection.

The inclusion of Vinelbine 50mg Vinorelbine Injection as an emerging treatment highlights the dynamic landscape of breast cancer management. While costs are a consideration, the potential benefits and advancements in treatment options underscore the ongoing progress in the fight against breast cancer. As we strive for a world where breast cancer is not just treatable but preventable, this guide stands as a call to action for continued advocacy, understanding, and active engagement in one's breast health journey.

[mihikavasant]

Understanding Black Spots on the Tongue: Causes, Remedies, and When to See a Dentist

Noticing black spots on your tongue can be concerning, but they often disappear within a few hours. This is usually due to stains on the taste buds from consuming certain foods and beverages like black tea, coffee, red wine, and blackberries. The appearance of black spots on the tongue can range from tiny dots to noticeable dark areas, and they are typically harmless. However, in some cases, they can be a sign of a more serious issue, so it's important to know when to seek medical advice. In this blog post, we will explore the causes of black spots on the tongue, natural remedies, and when it's time to visit the dentist.

What Do Black Spots on the Tongue Mean?

Black spots on the tongue refer to dark patches or spots that can vary in size and prominence. Most of the time, these spots are harmless and temporary, disappearing on their own within a day or two. However, if the spots persist for longer, they could indicate a more serious condition.

Some individuals have black spots on their tongues from birth, known scientifically as pigmented nevus, which is common among people with darker skin tones.

Common Causes of Black Spots on the Tongue

Stains from Food and Drinks: The most common cause of black spots is simply staining from the foods and drinks we consume. Beverages like black coffee, red wine, and foods like blueberries can leave temporary stains on the taste buds. Improving oral hygiene can usually resolve this harmless condition.

Hyperpigmentation: This occurs when there is an excess of pigment in the tongue, resulting in dark spots. Hyperpigmentation can also occur after starting chemotherapy or taking certain chemotherapy drugs, such as Fluorouracil, Vinorelbine, and Daunorubicin.

Oral Piercings and Tongue Injuries: Injuries to the tongue, such as accidental bites, cuts, or damage from a cracked tooth, can cause black spots. Similarly, oral piercings can lead to discoloration of the tongue.

Exposure to Chemicals: The tongue may react with certain chemicals, such as bismuth found in some medications, leading to temporary black spots. The tongue usually returns to its normal color after some time.

Tongue Cancer: Persistent black spots accompanied by lumps, swelling, or sores that do not heal may indicate tongue cancer, a serious condition requiring immediate medical attention.

Black Hairy Tongue: This condition occurs when dead cells accumulate on the surface of the tongue and do not shed properly. Poor oral hygiene, smoking, and excessive tobacco use are common causes.

Peutz-Jeghers Syndrome (PJS): PJS is a genetic disorder that can cause dark spots on the lips, inside the mouth, or on the tongue, resembling black spots.

How to Treat Dark Spots on the Tongue

In most cases, maintaining good oral hygiene can help dark spots disappear. If the spots persist for more than two or three days, it's advisable to seek medical attention. A dentist or specialist will typically perform a physical examination and may take samples to check for bacterial or fungal infections.

It's important to be open and honest with healthcare providers during the consultation, especially regarding habits like smoking and tobacco use. Based on the diagnosis, the healthcare provider will suggest appropriate treatments tailored to the cause of the black spots and any accompanying symptoms.

Key Takeaway

Most black spots on the tongue are harmless and will fade with improved oral hygiene. However, if they last longer than a couple of days, it’s important to consult a dentist or healthcare provider to determine the cause and receive appropriate treatment.

[hkmagicure]

Cervical Cancer Immunotherapy! Anti-PD-L1 therapy Libtayo (cemiplimab) approved in EU for recurrent or metastatic cervical cancer

HK-Magicure -- On November 22, Regeneron announced that the European Commission (EC) approved Libtayo (cemiplimab) as monotherapy for the treatment of adult patients with recurrent or metastatic cervical cancer and disease progression on or after platinum-based chemotherapy.

Cervical cancer is the fourth leading cause of cancer death in women worldwide and is most frequently diagnosed between the ages of 35 and 44. Approximately 600,000 new cases of cervical cancer and 350,000 deaths from cervical cancer occur worldwide each year. Almost all cases are caused by human papillomavirus (HPV) infection, with approximately 80% classified as squamous cell carcinoma (SCC; arising from cells lining the external portion of the cervix) and the remainder largely adenocarcinomas (arising from glandular cells lining the internal portion of the cervix). Cervical cancer is often curable when detected early and effectively managed, but treatment options are more limited in advanced stages.

The EC approval in advanced cervical cancer is based on data from the global Phase 3 EMPOWER-Cervical 1 trial. The trial evaluated Libtayo in comparison to an investigator's choice of chemotherapy (pemetrexed, vinorelbine, topotecan, irinotecan or gemcitabine) and enrolled 608 patients across 14 countries. Patients were allowed to enroll regardless of PD-L1 expression status, with 78% of patients having SCC and 22% having adenocarcinoma or adenosquamous carcinoma.

The primary endpoint for the trial was OS, analyzed first among patients with SCC, then in the total population.

Results from the trial demonstrated that those treated with Libtayo (n=304) compared to chemotherapy (n=304) experienced significant improvements in OS, progression-free survival (PFS) and objective response rate (ORR) including a:

In the total population, the risk of death was reduced by 31%, with a median OS of 12.0 months for Libtayo and 8.5 months for the chemotherapy arm;

In the patients with SCC, the risk of death was reduced by 27%, with a median OS of 11.1 months for Libtayo versus 8.8 months for the chemotherapy arm.

25% reduction of risk in progressive disease in the total population.

16% ORR for Libtayo, versus 6% for chemotherapy in the total population.

In addition to today's approval, Libtayo is approved in the European Union (EU) for the treatment of certain patients with advanced basal cell carcinoma (BCC), advanced cutaneous squamous cell carcinoma (CSCC) and advanced non-small cell lung cancer (NSCLC).

About Libtayo (cemiplimab)

Libtayo is a fully human monoclonal antibody targeting the immune checkpoint receptor PD-1 on T cells and was invented using Regeneron's proprietary VelocImmune technology. By binding to PD-1, Libtayo has been shown to block cancer cells from using the PD-1 pathway to suppress T-cell activation. In the U.S. and other countries, Libtayo is indicated in certain patients with advanced basal cell carcinoma (BCC), advanced cutaneous squamous cell carcinoma (CSCC) and advanced non-small cell lung cancer (NSCLC), as well as in advanced cervical cancer in the EU, Canada and Brazil.

For more articles on medicines, click here: hkmagicure

Hong Kong Magicure Medical Center has long been focusing on the import and export of new drugs, special drugs and rare disease drugs in the field of oncology. Welcome to inquiry: hkmagicure@gmail.com.

[indianfitnesscare]

Breast Cancer Has Survival Advantage With Sacituzumab

Breast Cancer Has Survival Advantage With Sacituzumab

The Federal Joint Committee (G-BA) had specified chemotherapy with capecitabine or vinorelbine or eribulin or, if necessary, a therapy containing anthracycline or taxane as appropriate comparator therapy. IQWiG sees a hint of a major added benefit of sacituzumab govitecan compared to the appropriate comparator therapy. The effects in overall survival were decisive for this positive assessment:…

[hematooncologist]

Side Effect of Chemotherapy: Hair Loss

Balding can occur as a symptom of chemotherapy, designated treatment, radiation treatment, or a foundational microorganism (bone marrow) relocate. These malignant growth medicines can hurt the cells that assist hair with developing. It can influence hair all around your body, including your head, face, arms, legs, underarms, and pubic region. The clinical term for going bald is alopecia.

Going bald is distinctive for everybody. You may lose all your hair or just segments of it. It may come out leisurely over the long haul or become slender. Or on the other hand you may essentially see that your hair is dryer and blunter. Lost hair normally develops back after disease and treatment. In any case, once in a while, hair remains flimsy Best Oncologist in East Delhi.

 Chemotherapy

Not all chemotherapy causes balding, but rather some chemotherapy drugs are bound to cause going bald or diminishing. They include:

•             Altretamine (Hexalen)

•             Carboplatin (Paraplatin)

•             Cisplatin (Platinol)

•             Cyclophosphamide (Neosar)

•             Docetaxel (Taxotere)

•             Doxorubicin (Adriamycin, Doxil)

•             Epirubicin (Ellence)

•             Fluorouracil (5-FU)

•             Gemcitabine (Gemzar)

•             Idarubicin (Idamycin)

•             Ifosfamide (Ifex)

•             Paclitaxel (different brand names)

•             Vincristine (Marqibo, Vincasar)

•             Vinorelbine (Alocrest, Navelbine)

This classification additionally incorporates chemotherapy given as a component of an immature microorganism/bone marrow relocate Best Oncologist in East Delhi.

 Hair doesn't generally drop out when you start chemotherapy. It generally requires a little while or patterns of treatment and will in general drop out 1 or 2 months into treatment Best Medical Oncologist in South Delhi.

How much hair you lose relies upon the medication and the portion. It additionally relies upon whether you get your chemotherapy as a pill, into a vein, or on the skin. What's more, how much going bald is distinctive for every individual? You and another person can take a similar medication for a similar disease and still lose various measures of hair Best Medical Oncologist in South Delhi.

Hair normally begins to develop back 1 to 90 days after chemotherapy closes. It regularly requires 6 to a year to develop back totally. It might develop back more slender, coarser, wavy, or an alternate tone. Hair generally returns to ordinary over the long run.

Radiation treatment

Radiation treatment just influences the hair on the body part where the radiation is pointed. For instance, assuming you have radiation treatment to the pelvis, you could lose pubic hair. Going bald relies upon the portion and technique for radiation treatment. It generally becomes back following a while, however it could be more slender or an alternate surface. With extremely high dosages of radiation treatment, hair may not develop back Best cancer specialist in East Delhi.

Designated treatment

Malignant growth prescriptions called designated treatment don't cause total balding. Yet, the accompanying designated treatments might make hair become more slender, curlier, or drier than expected Best cancer specialist in East Delhi.

•             Afatinib (Gilotrif)

•             Cetuximab (Erbitux)

•             Dabrafenib (Tafinlar)

•             Dasatinib (Sprycel)

•             Erlotinib (Tarceva)

•             Ibrutinib (Imbruvica)

•             Imatinib (Gleevec, Glivec)

•             Nilotinib (Tasigna)

•             Panitumumab (Vectibix)

•             Sonidegib (Odomzo)

•             Sorafenib (Nexavar)

•             Trametinib (Mekinist)

•             Vemurafenib (Zelboraf)

•             Vismodegib (Erivedge)

Hormonal treatment

At times, hormonal treatment for the disease can cause an individual's hair gets more slender. This might happen a while to years in the wake of beginning treatment. Hormonal treatment doesn't for the most part cause total balding. The accompanying hormonal treatments are bound to cause balding Best cancer specialist in South Delhi.

•             Anastrozole (Arimidex)

•             Fulvestrant (Faslodex)

•             Letrozole (Femara)

•             Octreotide (Sandostatin)

•             Tamoxifen (Nolvadex)

Losing your hair can cause in excess of an adjustment of your actual appearance. It very well may be an inner test that influences your mental self-portrait and personal satisfaction. It is vital to be benevolent to yourself during this unpleasant time Best cancer specialist in South Delhi.

Individuals adapt to going bald in various ways. Contemplating how you feel generally great in overseeing going bald previously, during, and after treatment might help. What's more, your decisions might change over the long run.

Discussing your sentiments with an instructor, a relative, or a companion might give solace. It might likewise be useful to interface with others who have encountered balding, for example, through an internet based care group, and discover what turned out best for them in adapting to it.

It could be useful to set up your loved ones about you conceivably losing hair. This is particularly valid for youngsters. They might feel less unfortunate and restless on the off chance that the adjustment of your appearance is something they anticipate. This, thus, can assist you with feeling much improved.

Cold cap treatment

Wearing a cap that cools the scalp can assist with keeping balding from drugs given through a vein. This treatment is called scalp cry therapy. You wear the cap previously, during, and after chemotherapy.

The virus makes the veins in the skin of your head smaller. Less blood and less of the chemotherapy drug arrives at your hair follicles through the veins. Keeping your scalp freezing likewise forestalls harm to the hair follicles.

 Chat with your medical services group to learn assuming virus cap treatment is accessible and might work for you.

Medications

An over-the-counter prescription called monoxide might help diminish hair from hormonal treatment or designated treatment. It might likewise help to assume your hair doesn't develop back totally after chemotherapy, radiation treatment, or an undifferentiated cell/bone marrow relocation Best Cancer Specialist in Delhi NCR.

There are likewise different meds you can take by mouth. These incorporate spironolactone (Aldactone) and finasteride (Propecia, Proscar).

Hair and scalp care

·         Here are a few hints to deal with your hair and scalp during malignant growth treatment.

Pick a delicate, aroma free cleanser. Try not to wash your hair consistently. Wash delicately. In the event that your hair tangles, consider utilizing items like a delicate conditioner or detangle shower Best Cancer Specialist in Delhi NCR.

·         Wipe your hair off to forestall harm. Try not to pull on your hair however much as could be expected. Style it delicately with a delicate brush or wide-toothed brush.

·         At the point when outside, use sun insurance on your scalp, like sunscreen, a cap, or a scarf.

·         Stay away from high-heat styling, synthetic twisting or fixing, and extremely durable or semi-super durable hair tone.

·         Pick a delicate, smooth pillowcase.

Chat with your medical services group assuming that you are keen on taking biotin, a kind of B nutrient.

[gabakins-blessedandhighlyfavored]

🌺🌸🌼🌻🌺🌸🌼🌻🌺🌸🌼🌻🌺🌸

Day 25. Today I researched Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle. It’s a species of flowering plant in the family Apocynaceae. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant. It is a source of the drugs vincristine and vinblastine, used to treat cancer. It was formerly included in the genus Vinca as Vinca rosea. The species has long been cultivated for herbal medicine, as it can be traced back to 2600 B.C.E. Mesopotamia. In Ayurveda (Indian traditional medicine) the extracts of its roots and shoots, though poisonous, are used against several diseases. In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma. In the 1950s, vinca alkaloids, including vinblastine and vincristine, were isolated from Catharanthus roseus by when screening for anti-diabetic drugs. This chance discovery led to increased research into the chemotheraputic effects of vinblastine and vincristine. Conflict between historical indigenous use, and recent patents on C.roseus-derived drugs by western pharmaceutical companies, without compensation, has led to accusations of biopiracy. Medicinal Vinblastine and vincristine , chemotherapy medications used to treat several types of cancers, are found in the plant and are biosynthesised from the coupling of the alkaloids catharanthine and vindoline. The newer semi-synthetic chemotherapeutic agent vinorelbine, used in the treatment of non-small-cell lung cancer, can be prepared either from vindoline and catharanthine or from the vinca alkaloid leurosine, in both cases via anhydrovinblastine. The insulin-stimulating vincoline has been isolated from the plant. A periwinkle shrub Dark pink colour Coming in different colours C. roseus can be extremely toxic if consumed orally by humans, and is cited (under its synonym Vinca rosea) in the Louisiana State Act 159.

🌺🌸🌼🌻🌺🌸🌼🌻🌺🌸🌼🌻🌺🌸

[freechaoskitten]

A Brief Introduction About MCL LeukemiaFrequently Asked QuestionsWhat is the USP of the report?What are the key content of the report?What are the value propositions and opportunities offered in this market research report?Related Reports

ML leukemia is a rare form of cancer that affects the blood and its functions. It can also affect the bone marrow. This type of cancer is not common, but still it has become one of the most serious health concern today. Since there is still no specific cure for this leukemia, most of the medical experts recommend the patients to undergo treatment and prevention at any cost.

Some studies show that mcl leukemia is more common among male patients. But the reason why is still unknown. However, it is known fact that the male gender is the cause of this cancer. This is due to the male hormone or testosterone that is present in their body.

When the cancer cells develop in the bone marrow, the immune system then attacks the cancerous cells. The immune system then attempts to kill the remaining cancer cells. However, since the number of leukemia cells increase, the body's immune system is now unable to fight against it.

Since the immune system has become weak, most of the patients are diagnosed with this type of cancer. Since the majority of the patients are diagnosed with this type of leukemia, they are also given treatments such as chemotherapy, radiotherapy, hormone therapy, and even surgery. Chemotherapy, on the other hand, is used to treat the cancerous cells. This drug is used for the patients that have large numbers of cancer cells in their body. Chemotherapy also has side effects on some patients.

Radiotherapy also is used to treat the cancer. This process involves high-energy rays being shot at the cancerous area. It can also be used on the bone marrow for the patients that have a history of cancer. However, it is also dangerous and sometimes the radiation damages some parts of the patients' body. Surgery is also another procedure that can treat the cancer.

Leukemia can also spread to other parts of the body. Most patients are diagnosed before the cancer cells spread. Since the treatment for the leukemia spreads the cancer cells around, the doctors will also perform blood transfusions to replenish the patients' lost blood. This treatment is called as transfusion.

The chemotherapy treatment also is done. It also involves drugs, radiation, and pain medications. However, the side effects of this treatment can cause the patients to become depressed and can also cause the patients to lose their appetite and to vomit.

The doctors always have to perform intensive research when treating mcl leukemia. This research involves studying the medical histories of the patients, their family background, the stages they are in, their physical capabilities, as well as their psychological condition. This is to prevent the occurrence of further cancer cells to develop in the future. Moreover, the doctors should also know the factors that contribute to the emergence of the cancer cells. The study will help the doctors to provide better mcl leukemia research treatment to the patients.

There are different types of chemotherapy for all leukemia. For the early stage, it usually uses combination therapy. In this case, the doctors use some medications that can not be tolerated by the patients. Therefore, these medications should not be taken by the patients immediately. They can also have an additional course of treatment for mcl.

At later stages, mcl leukemia may also use a single drug combination therapy. This treatment is usually very effective in reducing the number of the sick cells in the bone marrow. Moreover, it can also improve the immune function of the patient. The combination may leukemia drugs usually include drugs such as amnesties, carboplatin vinorelbine, cisplatin, etoprofen, gemcitabine, hylatingen, insulin, leupeptase, miotics, streptomycin, tobramycin, or trifluoperazine. A single drug can not treat all the symptoms and it can not totally cure the disease.

On the other hand, treatment for all leukemia can be given in an individualized way. This means that each mcl leukemia patient should receive a treatment based on the type of the disease and the stage of the disease. Sometimes, physicians use combination treatments. The patients should not depend solely on the doctor during the treatment. He/she should also take part in the decision making process and help in deciding which medication to use and the dosage.

Sometimes, all leukemia patients suffer from fatigue and shortness of breath. Sometimes, their lung capacity is affected. Mcl can also damage the digestive system. However, with proper care, these side effects can be overcome and can lead a normal life.

The research team projects that the Induced Myeloid Leukemia Cell Differentiation Protein Mcl 1 market size will grow from XXX in 2020 to XXX by 2027, at an estimated CAGR of XX. The base year considered for the study is 2020, and the market size is projected from 2020 to 2027.

The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing with 10 major regions and 50 major countries. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

By Market Players:

 AbbVie Inc

 Amgen Inc

 AstraZeneca Plc

 Complix NV

 Les Laboratoires Servier SAS

 Takeda Pharmaceutical Co Ltd

 Warp Drive Bio Inc

By Type

 AZD-5991

 FL-118

 S-64315

 UMI-77

 Others

By Application

 Ovarian Cancer

 Prostate Cancer

 Hemotological Tumor

 Non-Hodgkin Lymphoma

 Others

By Regions/Countries:

 North America

 United States

 Canada

 Mexico

East Asia

 China

 Japan

 South Korea

Europe

 Germany

 United Kingdom

 France

 Italy

 Russia

 Spain

 Netherlands

 Switzerland

 Poland

South Asia

 India

 Pakistan

 Bangladesh

Southeast Asia

 Indonesia

 Thailand

 Singapore

 Malaysia

 Philippines

 Vietnam

 Myanmar

Middle East

 Turkey

 Saudi Arabia

 Iran

 United Arab Emirates

 Israel

 Iraq

 Qatar

 Kuwait

 Oman

Africa

 Nigeria

 South Africa

 Egypt

 Algeria

 Morocoo

Oceania

 Australia

 New Zealand

South America

 Brazil

 Argentina

 Colombia

 Chile

 Venezuela

 Peru

 Puerto Rico

 Ecuador

Rest of the World

 Kazakhstan

Points Covered in The Report

 The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.

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The report focuses on Global, Top 10 Regions and Top 50 Countries Market Size of Induced Myeloid Leukemia Cell Differentiation Protein Mcl 1 2016-2021, and development forecast 2022-2027 including industries, major players/suppliers worldwide and market share by regions, with company and product introduction, position in the market including their market status and development trend by types and applications which will provide its price and profit status, and marketing status & market growth drivers and challenges, with base year as 2020.

Key Indicators Analysed

 Market Players & Competitor Analysis: The report covers the key players of the industry including Company Profile, Product Specifications, Production Capacity/Sales, Revenue, Price and Gross Margin 2016-2021 & Sales by Product Types.

 Global and Regional Market Analysis: The report includes Global & Regional market status and outlook 2022-2027. Further the report provides break down details about each region & countries covered in the report. Identifying its production, consumption, import & export, sales volume & revenue forecast.

 Market Analysis by Product Type: The report covers majority Product Types in the Induced Myeloid Leukemia Cell Differentiation Protein Mcl 1 Industry, including its product specifcations by each key player, volume, sales by Volume and Value (M USD).

 Markat Analysis by Application Type: Based on the Induced Myeloid Leukemia Cell Differentiation Protein Mcl 1 Industry and its applications, the market is further sub-segmented into several major Application of its industry. It provides you with the market size, CAGR & forecast by each industry applications.

 Market Trends: Market key trends which include Increased Competition and Continuous Innovations.

 Opportunities and Drivers: Identifying the Growing Demands and New Technology

 Porters Five Force Analysis: The report will provide with the state of competition in industry depending on five basic forces: threat of new entrants, bargaining power of suppliers, bargaining power of buyers, threat of substitute products or services, and existing industry rivalry.

COVID-19 Impact

 Report covers Impact of Coronavirus COVID-19: Since the COVID-19 virus outbreak in December 2019, the disease has spread to almost every country around the globe with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt, and will significantly affect the Induced Myeloid Leukemia Cell Differentiation Protein Mcl 1 market in 2021. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor/outdoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future.

 Induced Myeloid Leukemia Cell Differentiation Protein Mcl 1 Market report offers great insights of the market and consumer data and their interpretation through various figures and graphs. Report has embedded global market and regional market deep analysis through various research methodologies. The report also offers great competitor analysis of the industries and highlights the key aspect of their business like success stories, market development and growth rate.

Microscopic Polyangiitis (MPA) Treatment Market

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[thelotusbiotech]

Get Vinorelbine 50mg which is a chemotherapy medication used in the treatment of various cancers, including non-small cell lung cancer and breast cancer. It is a medication in the vinca alkaloid class that inhibits the development and division of cancer cells by interfering with the production of microtubules during cell division.

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Vinorelbine Report

OK, what fun things do people do once a week? I get chemotherapy! This is the first time since I was initially getting chemo that I’ve been on a weekly schedule and I definitely feel the difference. There’s not a whole lot of time for the side effects to hit and run their course before the next treatment, so I’m basically always having some kind of reaction all the time. 

I’ve had 3 treatments of vinorelbine and I’ll be getting 5 more weekly treatments before the next scan. The Good Doctor said he had a patient with sarcoma who had success with this drug, but that’s no guarantee of a similar outcome in my case. Honestly, at this point I just want it to stop the growth; I’m not even looking for shrinkage anymore. Just something.

So meantime, I’m super fatigued, having both extremes of digestive symptoms and having some serious muscle aches. But the good news is that there’s no sign of my hair falling out or even thinning, so that’s something positive. It’s good to have something positive. Anything.

[arroseworld]

treatments for lung cancer

Treatment for lung cancer;

Surgery

Chemotherapy

radiation therapy.

TREATMENTS MAY INCLUDE;

Chemotherapy:

One or more of the following drugs are given intravenously to kill the affected cells.

Carboplatin. Gemcitabine. Nab-Paclitaxel. Paclitaxel. Pemetrexed. Vinorelbine

Targeted therapeutic drugs:

They target abnormalities in affected cells and kill cancer cells. Erlotinib, Procedure

Pulmonary lobectomy:

This is one of the most effective methods and is performed by removing one of the lobes of the lung.

Lung segmentation:

This surgical procedure removes a portion of the lung.

Pneumonectomy:

In this case, the entire lung is removed.

Pulmonary wedge resection:

If the flap is difficult to remove, the tumor will be removed along with some healthy tissue.

Therapy

Radiation therapy: cancer cells are killed by high-energy rays, which eliminate all lung cancer cells

[cancertame3]

What is Chemotherapy?

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more chemotherapeutic agents (anti-cancer drugs) to destroy rapidly growing cells in the body, such as cancer cells which grow and divide faster than other cells in the body. Chemotherapy is primarily used to lower the total number of cancerous cells in the body and shrink tumour size. In the case of advanced stage cancers, chemotherapy may help to relieve pain.

History of Chemotherapy

The use of chemotherapy to treat cancer began at the start of the 20th century. Several attempts were made to narrow down the chemicals that might affect the disease by developing various methods to screen chemicals using transplantable tumours in the rodents. Chemotherapy was first coined as a word in the early 1900s by a German chemist Paul Ehrlich, who defined it as the use of chemicals to treat disease[1].

During World War I, mustard gas was used as a chemical warfare agent. It was discovered that the gas was a potent suppressor of haematopoiesis (blood production). Similarly, nitrogen mustards were studied during World War II after the effects of an accidental spill of sulphur mustards on troops from a bombed ship in Bari Harbour, Italy[2]. This incident led to an observation that both bone marrow and lymph nodes were marked depleted in those who were exposed to mustard gas. It was believed that an agent which could damage the rapidly growing white blood cells might have a similar effect on cancer. The first chemotherapeutic drug developed from this research was Mustine (chlormethine, sold under the brand name of Mustargen). Sidney Farber collaborated with Lederle Laboratories to develop a series of folic acid analogues. These compounds included aminopterin and amethopterin, now known as methotrexate. Farber tested these antifolate compounds in children with leukaemia and in 1948, the results of these tests showed unquestionable remissions[3]. Farber is regarded as the father of modern chemotherapy.

In the mid-1950s, Charles Heidelberger and his colleagues developed a drug that was aimed at non-hematologic cancers[4]. Heidelberger “targeted” a biochemical pathway by attaching a fluorine atom to the 5-position of the uracil pyrimidine base which resulted in the synthesis of fluoropyrimidine 5-fluorouracil (5-FU). This agent was found to have broad-spectrum activity against a range of solid tumours and to this day, remains the cornerstone for the treatment of colorectal cancer. This agent represents the very first example of targeted therapy which has now become a focus in current cancer drug development, although the target, in this case, was a biochemical pathway instead of a molecular pathway.

Methods

There are a number of methods in the administration of chemotherapeutic drugs used today. Chemotherapy may be given with a curative intent or it may aim to prolong life or as palliative care. Induction chemotherapy is considered as the first line of treatment of cancer with a chemotherapeutic drug. It is usually given with curative intent.

Combined modality chemotherapy is the use of drugs along with other cancer treatments like surgery, radiation therapy, ayurvedic treatment (such as Cancertame), homeotherapy treatment etc

Combination chemotherapy involves treating a person with a number of different drugs simultaneously. This is one of the most used methods in chemotherapy as it minimises the chances of resistance developing to any one agent. For the treatment of bladder cancer, for example, a combination of Methotrexate, vincristine, doxorubicin, cisplatin is used

Neoadjuvant chemotherapy is given with an aim to shrink the tumour prior to principal treatment such as radiotherapy or surgery[5]

Adjuvant chemotherapy is given after principal treatment. It is an effective treatment if the cancerous cells have spread to other parts of the body

Types of Chemotherapy

1) Alkylating agents are the oldest group of chemotherapeutics in use today. There are several types of alkylating agents used in chemotherapy treatments such as:

Mustard gas derivatives -  Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide

Ethylenimines - Thiotepa and Hexamethylmelamine

Alkyl sulfonates - Busulfan

Hydrazines and Triazines - Altretamine, Procarbazine, Dacarbazine and Temozolomide

Nitrosoureas - Carmustine, Lomustine and Streptozocin.  Nitrosoureas are unique because, unlike most types of chemo treatments, they can cross the blood-brain barrier.  They can be useful in treating brain tumours.

Metal salts - Carboplatin, Cisplatin, and Oxaliplatin

2) Antimetabolites are a group of molecules which impede DNA and RNA synthesis such as:

Folic acid antagonist - Methotrexate

Pyrimidine antagonist - 5-Fluorouracil, Floxuridine, Cytarabine, Capecitabine, and Gemcitabine

Purine antagonist - 6-Mercaptopurine and 6-Thioguanine

Adenosine deaminase inhibitor - Cladribine, Fludarabine, Nelarabine and Pentostatin

3) Topoisomerase Inhibitors are drugs which interfere with the action of topoisomerase enzymes which control the manipulation of the structure of DNA necessary for replication

Topoisomerase I inhibitors - Irinotecan, topotecan

Topoisomerase II inhibitors - Amsacrine, etoposide, etoposide phosphate, teniposide

4) Plant Alkaloids are chemotherapy treatments derived from certain types of plants.

Vinca alkaloids (made from Catharanthus roseus) - Vincristine, Vinblastine and Vinorelbine

Taxanes (made from Taxus) - Paclitaxel and Docetaxel

Podophyllotoxins (derived from may apple plant) - Etoposide and Tenisopide

Camptothecin analogues (derived from camptothecin acuminate) - Irinotecan and Topotecan

Side Effects of Chemotherapy

Chemotherapy can produce adverse side effects that range from mild to severe, depending on the type and extent of the treatment. Some people may experience adverse to a few side effects which vary from person to person and the stage of cancer. Toxicities related to chemotherapy can occur acutely within hours to days, or chronically, after weeks to years[6].

Some common side effects of chemotherapy are:

Nausea and vomiting

Hair loss

Skin changes

Nail changes

Fatigue

Hearing impairment

Infections

Bleeding problems

Anaemia

Loss of appetite

Bowel problems

Cognitive and mental health problems

Luckily, due to advancement in medical research, ayurvedic drugs such as Cancertame when taken along with chemotherapy can minimize such side effects providing for a better integrative treatment for cancer patients.

New Treatment Management Protocols

The practice of utilizing chemotherapy for the treatment of cancer began in the 1940s and still remains a fundamental treatment for various types of cancer. Given the poisonous origin of chemotherapy, patients receiving these treatments experienced some severe side effects which create a demand for new treatment management protocols. Research over the past 30 years has led to the discovery of medications aimed at reducing the side effects of chemotherapy.

Targeted therapies became more popular and are one of the major focus of current cancer drug development. Although the very first use of this method was done back in the 1950s, this therapy aims for the specific targets that are specific to cancer cells and do not occur or are rare in healthy cells

Electrochemotherapy is a combined treatment in which an injection of a chemotherapeutic drug is followed by the application of high-voltage electric pulses to the tumour. This treatment enables the chemotherapeutic drugs, which cannot or hardly go through the membrane of cells, to enter cancer cells

Hyperthermia therapy is a heat treatment of cancer that can be very effective if combined with chemotherapy. The heat can be applied locally to the tumour site, which will dilate blood vessels to the tumour, allowing the more chemotherapeutic medication to enter the tumour. The tumour cell membrane will become more porous which will further allow more of the chemotherapeutic medicine to enter the tumour cell

Other medications such as Cancertame can also help to reduce the side effects of chemotherapy by enhancing the immune system of the body, and also helps to fight the growth of cancer by inducing apoptosis (cell death) and inhibiting tumour angiogenesis.

References

DeVita VT, Chu E (November 2008). "A history of cancer chemotherapy". Cancer Research. 68 (21): 8643–53

Krumbhaar EB, Krumbhaar HD. The blood and bone marrow in yellow gas (mustard gas) poisoning. Changes produced in bone marrow in fatal cases. J Med Res 1919; 40: 497–508

Farber S, Diamond LK, Mercer RD, et al. Temporary remissions in acute leukaemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin). N Eng. J Med 1948; 238: 787–93

Heidelberger C, Chaudhuari NK, Danenberg P, et al. Fluorinated pyrimidines. A new class of tumor inhibitory compounds. Nature 1957; 179: 663–6

Rachel Airley (2009). Cancer chemotherapy. Wiley-Blackwell

https://www.cancertame.com/in/article.php?title=What%20is%20Chemotherapy?&article_id=VmtkNFUxSXdjM2xYYmxaV1ltMTRjbFpxUmxaUFVUMDk=

https://www.cancertame.com

[oncologistdrmanish]

Best Way to Treat Lung Cancer

Lung cancer affects more than 200,000 Americans each year. Although cigarette smoking is the main cause, anyone can develop lung cancer. Lung cancer is always treatable, no matter the size, location, whether the cancer has spread, and how far it has spread.

Because lung cancer is associated with smoking, patients may feel that they won’t receive much support or help because they believe that others will think that their behavior caused the disease. The truth is that most smokers do not develop lung cancer, and not all people diagnosed with lung cancer smoke. Lung cancer is a disease that can affect anyone. In fact, most people who get lung cancer today have either stopped smoking years earlier or never smoked.

Treatment overview

In cancer care, different types of doctors often work together to create a patient’s overall treatment plan that combines different types of treatments. This is called a multidisciplinary team. Cancer care teams include a variety of other health care professionals, such as physician assistants, nurse practitioners, oncology nurses, social workers, pharmacists, counselors, dietitians, and others.

There are 5 main ways to treat NSCLC:

Surgery

Radiation therapy

Chemotherapy

Targeted therapy

Immunotherapy

Surgery

The goal of surgery is to completely remove the lung tumor and the nearby lymph nodes in the chest. The tumor must be removed with a surrounding border or margin of healthy lung tissue. A “negative margin” means that when the pathologist examined the lung or a piece of lung that was removed by the surgeon, no cancer was found in the healthy tissue surrounding the tumor. A surgical oncologist is a doctor who specializes in treating cancer using surgery. A thoracic surgeon is specially trained to perform lung cancer surgery.

The following types of surgery may be used for NSCLC:

Lobectomy. The lungs have 5 lobes, 3 in the right lung and 2 in the left lung. A lobectomy is the removal of an entire lobe of the lung. It is currently thought to be the most effective type of surgery, even when the lung tumor is very small.

A wedge resection. If the surgeon cannot remove an entire lobe of the lung, the surgeon can remove the tumor, surrounded by a margin of healthy lung.

Segmentectomy. This is another way to remove the cancer when an entire lobe of the lung cannot be removed. In a segmentectomy, the surgeon removes the portion of the lung where the cancer developed.

Pneumonectomy. If the tumor is close to the center of the chest, the surgeon may have to remove the entire lung.

These types of adjuvant therapy used for NSCLC include radiation therapy and systemic therapies, such as chemotherapy, targeted therapy, and immunotherapy. Each therapy is described below.

Radiation therapy 

Radiation therapy is the use of high energy x-rays or other particles to destroy cancer cells. If you need radiation therapy, you will see a specialist called a radiation oncologist. A radiation oncologist is the doctor who specializes in giving radiation therapy to treat cancer. The most common type of radiation treatment is called external-beam radiation therapy, which is radiation given from a machine outside the body. A radiation therapy regimen, or schedule, usually consists of a specific number of treatments given over a set period of time. This can vary from just a few days of treatment to several weeks.

Like surgery, radiation therapy cannot be used to treat widespread cancer. Radiation therapy only destroys cancer cells directly in the path of the radiation beam. It also damages the healthy cells in its path. For this reason, it cannot be used to treat large areas of the body.

Sometimes, CT scans (see Diagnosis) are used to plan out exactly where to direct the radiation beam to lower the risk of damaging healthy parts of the body. This is called intensity modulated radiation therapy (IMRT) or stereotactic body radiation therapy (SBRT). It is not an option for all patients, but it may be used for early-stage disease and small tumors when surgery is not an option.

Some people with Stage I NSCLC or people who cannot have surgery may be treated with radiation therapy as an alternative treatment to surgery.Best lung cancer in delhi.

Chemotherapy

Chemotherapy is the use of drugs to destroy cancer cells, usually by keeping the cancer cells from growing, dividing, and making more cells. It has been shown to improve both the length and quality of life for people with lung cancer of all stages.

A chemotherapy regimen, or schedule, usually consists of a specific number of cycles given over a set period of time. The type of lung cancer you have, such as adenocarcinoma or squamous cell carcinoma, affects which drugs are recommended for chemotherapy.

Common drugs used to treat lung cancer include either 2 or 3 drugs given together or 1 drug given by itself. Some common drugs include.

Carboplatin or cisplatin (both are available as generic drugs)

Docetaxel (Taxotere)

Gemcitabine (Gemzar)

Nab-paclitaxel (Abraxane)

Paclitaxel (Taxol)

Pemetrexed (Alimta)

Vinorelbine (Navelbine)

Chemotherapy may also damage healthy cells in the body, including blood cells, skin cells, and nerve cells. The side effects of chemotherapy depend on the person and the dose used, but they can include fatigue, low numbers of blood cells, risk of infection, mouth sores, nausea and vomiting, loss of appetite, diarrhea, numbness and tingling in the hands and feet, and hair loss. Some lung cancer chemotherapy treatments do not cause significant hair loss.

Your medical oncologist can often prescribe drugs to help relieve many of these side effects. Hormone injections may be used to prevent white blood cell counts from becoming too low. Nausea and vomiting are also often avoidable. Learn more about preventing nausea and vomiting caused by cancer treatment. In many cases, side effects usually go away after treatment is finished.

Targeted therapy

Targeted therapy is a treatment that targets the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. This type of treatment blocks the growth and spread of cancer cells and limits damage to healthy cells.

Not all tumors have the same targets. To find the most effective treatment, your doctor may run tests to identify the genes, proteins, and other factors in the tumor. For some lung cancers, abnormal proteins are found in unusually large amounts in the cancer cells. This helps doctors better match each patient with the most effective treatment whenever possible. In addition, research studies continue to find out more about specific molecular targets and new treatments directed at them. Learn more about the basics of targeted treatments.

Immunotherapy

Immunotherapy, also called biologic therapy, is designed to boost the body's natural defenses to fight the cancer. It uses materials made either by the body or in a laboratory to improve, target, or restore immune system function. For example, the PD-1 pathway may be very important in the immune system’s ability to control cancer growth. Blocking this pathway with PD-1 and PD-L1 antibodies has stopped or slowed the growth of NSCLC for some patients. The following immunotherapy drugs block this pathway:

Atezolizumab (Tecentriq)

Durvalumab (Imfinzi)

Nivolumab (Opdivo)

Pembrolizumab (Keytruda)

[higherfeed]

What is Mesothelioma Chemotherapy? and how chemotherapy for mesothelioma..!

Chemotherapy for Mesothelioma....

Meaning literally "chemical therapy", the term "chemotherapy" refers to the treatment of any disease with some type of drug or "chemical". However, it is best known specifically as a way to treat cancer. It is often recommended for the treatment of mesothelioma, either on its own, before or after surgery, or in conjunction with radiation therapy. The use of multiple types of therapy is known as multimodal treatment. ]] In short, chemotherapy works to stop the multiplication of cancer cells by killing them. Cancer cells, unlike healthy cells, grow out of control and become tumors that affect the function of organs. Chemotherapy drugs are designed to stop this rampant growth. For patients with pleural mesothelioma, some chemotherapy drugs work better than others, and there are more than 100 drugs currently on the market. Chemotherapy does not offer a cure for mesothelioma patients, but it can save time. Scientists continue to invent new treatments to combine with chemotherapy that increase the lifespan of people with pleural mesothelioma. READ MORE : 10 Tips for being healthy Chemotherapy can cause serious side effects, but it can prolong the survival of many people with pleural mesothelioma. It can be frightening to consider chemotherapy treatment. Fortunately, modern medicines and therapies help patients control symptoms better than in the past.   Chemotherapy and Pleural Mesothelioma

]] Chemotherapy drugs are often administered in pairs. Currently, the combination of chemotherapy most commonly used for cancer treatment of pleural mesothelioma is a combination of pemetrexed, also known by its trade name Alimta, and cisplatin. These are the only chemotherapy drugs approved by the FDA for the treatment of pleural mesothelioma. A phase III trial in 2003 found that approximately 41 percent of patients with pleural mesothelioma respond to the combination of pemetrexed and cisplatin. Experts point out that folate and vitamin B12 should be given when this combination is used because pemetrexed interferes with the normal metabolism of these vital nutrients. The toxicity is reduced with vitamin supplementation and the median survival for trial participants who received B12 and folic acid was 13.3 months.   Other chemotherapy drugs most commonly used in the treatment of pleural mesothelioma include:

]] Gemcitabine Gemcitabine is often given as second-line chemotherapy or for patients who can not easily tolerate platinum-based medications such as cisplatin and carboplatin. A phase II trial of 2002 on the combination of gemcitabine and cisplatin reported a response rate of 33 percent, which means that the tumors were reduced to some degree but did not disappear. Vinorelbine Vinorelbine is another second-line chemotherapy drug that works for some people with pleural mesothelioma. A study conducted in 2009 with 63 people with recurrent pleural mesothelioma reported that vinorelbine reduced tumors in 16 percent of participants and overall survival was 9.6 months. READ MORE : These 5 Tips make your teeth Clean, if you taking Tobacco Carboplatin Carboplatin is a platinum-based drug such as cisplatin, but it tends to cause fewer side effects. A 2006 phase II trial of the combination of carboplatin and pemetrexed in 102 patients with pleural mesothelioma reported a complete response in two patients, meaning that their tumors disappeared completely. The tumors were reduced by 18.6 percent of the participants, and 47 percent did not have a new tumor growth after treatment. The median overall survival was 12.7 months. Doxorubicin Doxorubicin is another option for second-line chemotherapy drugs for recurrent pleural mesothelioma. In 2011, the results of a phase II trial with doxorubicin combined with valproic acid (an anticonvulsant that destroys mesothelioma cancer cells) were published in 45 patients with pleural mesothelioma. The tumors were reduced in 16 percent of the participants, and 36 percent did not have a new tumor growth. The mean survival was 16.7 months for 16 percent of the participants with tumor shrinkage. Your doctor will determine which ones are best for you. If you do not tolerate a particular medication, a change can usually be made. The effectiveness of any of these medications will depend on a variety of factors including the stage of the cancer and your overall health. New chemotherapy drugs are constantly being developed and some are promising in the fight against pleural mesothelioma.   Read the full article

[shrikrisharathod]

Exhaustive Study on Vinorelbine Market 2019 | Strategic Assessment by Top Players like  Hospira, Nanjing Cuccess Pharmaceutical Co., TEVA Pharms

Vinorelbine (Navelbine®) is a chemotherapy drug used to treat non-small cell lung cancer and breast cancer that has come back after treatment. It may also be used to treat other cancers.

The research report, labeled Global Vinorelbine  Market Report 2025, provides a clear understanding of the subject. This report was collected using the main and sub research methodology. Both of these methods focus on working with accurate and meticulous data about market dynamics, historical events and the current market environment. Recent research data has allowed professionals to understand their ideas for market development.

Key Players Mentioned: Pierre Fabre Pharmaceuticals, Inc., TEVA Pharms, Hospira, Inc., West-Ward Pharmaceuticals Corp., Fresenius Kabi, EBEWE Pharma (Sandoz A Novartis Division), Jiangsu Hansoh Pharmaceutical Group Co., Ltd., Mylan, Dr. Reddy's Laboratories, Hangzhou Minsheng Pharmaceutical Group Co., Ltd., Nanjing Cuccess Pharmaceutical Co., Ltd, Qilu Pharmaceutical (Hainan) Co., Ltd., Sinopharm A-Think Pharmaceutical Co., Ltd., Beijing SL Pharm, Shenzhen Main Luck Pharmaceuticals Inc., Shanxi Powerdone Pharmaceutics Co., Ltd., Luoxin Pharmaceutical Group Co., Ltd Request Sample @t: https://introspectivemarketresearch.com/request-samples.php?_id=&_sid=417

 This report provides a comprehensive assessment of the Vinorelbine  market. We do this with in-depth qualitative insight, historical data, and verifiable predictions of market size. It also provides key details such as production capacity, manufactured product type, gross margin, global product production share, production value, company contact information and manufacturing process. A key factor driving market growth is the growing demand for efficient energy solutions.

Product Segment Analysis: Oral, Injection

Application Segment Analysis: Breast Cancer, Lymphoma, Non-small Cell Lung Cancer, Others

Regional Segment Analysis: North America, Europe, Asia-Pacific and Rest of the World

The report clearly shows that the Vinorelbine  industry has grown significantly. Based on an in-depth assessment of the industry. The analysis provided in this report reveals key sectors and strong insights that can help you determine new strategies that have a strong presence in the industry. In conclusion, analysts who value unbiased information about stakeholders, investors, product managers, marketing executives, supply, demand, and future forecasts value the report. Ask For Discount @t: https://introspectivemarketresearch.com/ask-for-discount.php?_id=&_sid=417

 The report on the Vinorelbine  Market is designed to motivate competent analysts to serve as the ultimate guide for investors, stakeholders and business people to make decisions to increase market growth. This report has market statistics, value and other factors that may affect the market. The market is studied during the forecast period from 2019 to 2025.

Target Audience of the Global Vinorelbine  Market in Market Study: • Key Consulting Companies & Advisors • Large, medium-sized, and small enterprises • Venture capitalists • Value-Added Resellers • Third-party knowledge providers • Investment bankers • Investors Inquiry @t: https://introspectivemarketresearch.com/Enquiry-before-buying.php?_id=&_sid=417

 About Us: Introspective Market Research is a visionary research company who is ready to assist their customer to flourish their business by offering strategies for gaining success. We sell market research reports received from other leading companies in the market research industry which offer in-depth and trustworthy information on different topics and sectors. The IMR founded by the team of experts and experienced professionals in the industry. The team is focusing on offering the empirical data collected from experts that can be the base for the next few years. The Aim of the company is to offering reports from numerous sectors such as FMCG, technology, food beverages, media, chemical, and healthcare among others. Contact Us: 3001 S King Drive, Chicago, Illinois, U.S.A 60616 +1-773-382-1047 Web: https://www.introspectivemarketresearch.com

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[pharmaphorumuk]

Merck & Co’s Keytruda fails in triple negative breast cancer trial

Most of the time, Merck & Co’s Keytruda (pembrolizumab) has been a consistent performer across a range of cancers – but it has produced an uncharacteristic failure in tough to treat triple negative breast cancer.

US-based Merck tested Keytruda, an anti-PD-1 immunotherapy, as monotherapy in second or third line in patients with metastatic triple negative breast cancer (TNBC).

This is a rare form of the disease that lacks the three most common receptors found on the disease, which interact with the hormones oestrogen, progesterone and human epidermal growth factor 2 (HER2).

Results of the phase 3 KEYNOTE-119 trial showed Keytruda missed its primary endpoint by failing to improve overall survival compared with standard chemotherapy – capecitabine, eribulin, gemcitabine or vinorelbine.

The study randomised 622 patients to receive either Keytruda as monotherapy (200 mg fixed dose every three weeks for up to 24 months) or a physician’s choice of single-agent chemotherapy at a ratio of 1:1.

Other endpoints were not formally tested per the study protocol because the primary endpoint of overall survival was not met, although there were no new surprises in terms of Keytruda’s safety.

The US pharma is testing several chemotherapy and Keytruda cocktails in TNBC patients in the KEYNOTE-522 trial.

This trial started in 2017, and initial results are expected soon and could potentially lead to approval as a neoadjuvant therapy administered before an operation, or as an adjuvant to hit remaining disease after surgery.

Until earlier this year there were no immunotherapies approved at all in triple negative breast cancer, leaving patients with chemotherapy as the only treatment option.

But in March Roche’s Genentech unit got its Tecentriq (atezolizumab) approved in combination with Celgene’s Abraxane (nab-paclitaxel) in TNBC patients whose locally advanced or unresectable tumours express the protein PD-L1.

Roy Baynes

Merck & Co’s head of global clinical development, Dr Roy Baynes, said: “While we are disappointed by the outcome of this monotherapy trial, we are continuing to study Keytruda in earlier stages of the disease and in combination with chemotherapy to address the unmet medical need of patients with triple negative breast cancer. We are grateful to the patients and investigators for their participation in this important study.”

The post Merck & Co’s Keytruda fails in triple negative breast cancer trial appeared first on Pharmaphorum.

from Pharmaphorum https://pharmaphorum.com/news/merck-cos-keytruda-fails-in-triple-negative-breast-cancer-trial/