#ultraviolet absorption by biomolecules

[biology-geology-beaches-india]

TSRNOSS, p 710.

[spookysaladchaos]

Fluorescent Dye, Global Market Size Forecast, Top 11 Players Rank and Market Share

Fluorescent Dye Market Summary

According to the new market research report “Global Fluorescent Dye Market Report 2023-2029”, published by QYResearch, the global Fluorescent Dye market size is projected to grow from USD 949.1 million in 2023 to USD 1311 million by 2029, at a CAGR of 5.5% during the forecast period.

Fluorescent dyes are special chemicals that have the ability to absorb visible or ultraviolet light and re-emit longer wavelength fluorescent light. This ability makes fluorescent dyes very useful in a variety of applications, including fields such as biomedical research, cell labeling, drug screening, materials science, and labeling technology.

Key features of fluorescent dyes include:

Absorption and Emission Wavelengths: Fluorescent dyes absorb light from shorter wavelengths (usually ultraviolet or visible) and then re-emit fluorescent light at longer wavelengths. The wavelength of this emitted light usually depends on the molecular structure of the dye.

Brightness of Emitted Light: Fluorescent dyes typically emit fluorescence with high brightness, making them powerful tools for detecting and observing tiny structures and biomolecules.

Excitation light source: Fluorescent dyes require an external light source to excite them to emit light, usually using UV lamps, lasers, or visible light sources.

Fluorescent color: Different fluorescent dyes can emit different colors of fluorescence, from purple to red, and even near-infrared light.

Stability: A good fluorochrome is usually stable enough to last in an experiment or application.

Fluorescent dyes are widely used in life science research to label and track biomolecules such as proteins, DNA, and RNA in order to visualize and analyze their location and activity. Fluorescent dyes are classified into protein-based fluorescent dyes, organic fluorescent dyes, and organic polymers. In addition, fluorescent dyes are also widely used in the fields of material science, environmental monitoring, food industry and safety marking. Different fluorescent dyes have different properties and are suitable for a variety of different application needs.

Figure.   Global Fluorescent Dye Market Size (US$ Million), 2018-2029

Based on or includes research from QYResearch: Global Fluorescent Dye Market Report 2023-2029.

Market Drivers:

Increased Demand in Life Science Research: Fluorescent dyes are widely used in the fields of biomedical research, cell biology, and molecular biology to label and visualize biomolecules, and developments in these areas are driving the growth of the fluorescent dyes market.

Medical Diagnosis and Therapy: Fluorescent dyes have potential applications in medical diagnosis, tumor labeling, surgical navigation, and drug delivery, and the demand for new fluorescent dyes is growing for these applications.

Materials Science and Nanotechnology: Fluorescent dyes are used in materials science to research and develop new materials, especially in the fields of optoelectronics and nanotechnology.

Environmental monitoring: Fluorescent dyes can be used to monitor water quality, air quality and environmental pollution, and these applications are of great value in the field of environmental protection.

Food and Beverage Industry: Fluorescent dyes are used to detect contaminants in food and for quality control to ensure product quality and safety.

Restraint:

Cost and Availability: High-performance fluorochromes are often expensive, which may limit adoption for some applications. Also, some specific types of dyes may be in short supply.

Stability and Toxicity Issues: Some fluorochromes may become destabilized or toxic with prolonged use or at high concentrations. This may limit their use in certain applications.

Market competition: The fluorescent dye market is highly competitive, and continuous innovation and development of new dyes are required to meet market demand.

Opportunity:

Research and development of novel dyes: Development of more stable, brighter, and more sustainable fluorescent dyes will provide market opportunities. These dyes could be used in a wider range of applications, including life sciences, energy storage and optoelectronics.

Custom dyes: Services that provide custom fluorescent dyes and labeling systems to meet the needs of specific applications will be a growth opportunity. This personalized approach can meet the requirements of different customers.

Development of biological imaging technology: With the continuous advancement of biological imaging technology, the demand for more sensitive, multi-spectral fluorescent dyes will increase. This will drive the development of new dyes and imaging techniques.

Increased demand for environmental monitoring: As environmental pollution issues intensify, the demand for fluorescent dyes capable of efficient monitoring and detection will continue to grow.

Figure.   Fluorescent Dye, Global Market Size, The Top Five Players Hold 50% of Overall Market

Based on or includes research from QYResearch: Global Fluorescent Dye Market Report 2023-2029.

This report profiles key players of Fluorescent Dye such as Thermo Fisher (Life Technologies)、BD Biosciences、Merck Millipore、Bio-Rad Laboratories、PerkinElmer (BioLegend, Inc)

In 2022, the global top five Fluorescent Dye players account for 55.5% of market share in terms of revenue. Above figure shows the key players ranked by revenue in Fluorescent Dye.

Figure.   Fluorescent Dye, Global Market Size, Split by Product Segment

Based on or includes research from QYResearch: Global Fluorescent Dye Market Report 2023-2029.

In terms of product type, type one is the largest segment, hold a share of 50.5%.

Figure. Fluorescent Dye, Global Market Size, Split by Application Segment

Based on or includes research from QYResearch: Global Fluorescent Dye Market Report 2023-2029.

In terms of product application, application one is the largest application, hold a share of 44.16%.

Figure.   Fluorescent Dye, Global Market Size, Split by Region (Production)

Based on or includes research from QYResearch: Global Fluorescent Dye Market Report 2023-2029.

Figure.   Fluorescent Dye, Global Market Size, Split by Region

Based on or includes research from QYResearch: Global Fluorescent Dye Market Report 2023-2029.

About The Authors

Ziyi Fan

Lead Author

Consumer Goods,

Equipment & Parts, Packaging, etc.

About QYResearch

QYResearch founded in California, USA in 2007.It is a leading global market research and consulting company. With over 16 years’ experience and professional research team in various cities over the world QY Research focuses on management consulting, database and seminar services, IPO consulting, industry chain research and customized research to help our clients in providing non-linear revenue model and make them successful. We are globally recognized for our expansive portfolio of services, good corporate citizenship, and our strong commitment to sustainability. Up to now, we have cooperated with more than 60,000 clients across five continents. Let’s work closely with you and build a bold and better future.

QYResearch is a world-renowned large-scale consulting company. The industry covers various high-tech industry chain market segments, spanning the semiconductor industry chain (semiconductor equipment and parts, semiconductor materials, ICs, Foundry, packaging and testing, discrete devices, sensors, optoelectronic devices), photovoltaic industry chain (equipment, cells, modules, auxiliary material brackets, inverters, power station terminals), new energy automobile industry chain (batteries and materials, auto parts, batteries, motors, electronic control, automotive semiconductors, etc.), communication industry chain (communication system equipment, terminal equipment, electronic components, RF front-end, optical modules, 4G/5G/6G, broadband, IoT, digital economy, AI), advanced materials industry Chain (metal materials, polymer materials, ceramic materials, nano materials, etc.), machinery manufacturing industry chain (CNC machine tools, construction machinery, electrical machinery, 3C automation, industrial robots, lasers, industrial control, drones), food, beverages and pharmaceuticals, medical equipment, agriculture, etc.

[awesomechrisharry]

Innovations in Analytical Chemistry: The Role of Spectrometry in Industry

Spectrometry is a powerful analytical technique used to determine the composition of substances by measuring the interaction between matter and electromagnetic radiation. It plays a crucial role in various scientific and industrial applications. Here's an overview of the key technologies and applications in spectrometry:

1. Technologies:

a. Atomic Spectrometry:

- Involves the analysis of atoms and their elemental composition. Techniques such as atomic absorption spectroscopy (AAS) and atomic emission spectroscopy (AES) fall under this category.

b. Molecular Spectrometry:

- Focuses on the study of molecules and their structure. Techniques like infrared (IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy are part of molecular spectrometry.

c. Mass Spectrometry:

- Measures the mass-to-charge ratio of ions and is widely used for identifying and quantifying compounds. It includes techniques like gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS).

2. Applications:

a. Pharmaceuticals:

- Spectrometry is used in pharmaceutical analysis for drug formulation, quality control, and the detection of impurities. Mass spectrometry is particularly valuable in drug discovery.

b. Biotechnology:

- In biotechnology, spectrometry is employed for protein characterization, DNA sequencing, and the analysis of biomolecules. Mass spectrometry is widely used in proteomics and metabolomics studies.

c. Industrial Chemistry:

- Spectrometry plays a role in industrial chemistry for quality control, process monitoring, and the analysis of raw materials. Atomic and molecular spectrometry are applied in various manufacturing processes.

d. Environmental Testing:

- Environmental monitoring involves the use of spectrometry for the analysis of air, water, and soil samples. This includes identifying pollutants, monitoring chemical composition, and assessing environmental health.

e. Food & Beverage Testing:

- Spectrometry is crucial in ensuring the safety and quality of food and beverages. It is used for detecting contaminants, determining nutritional content, and verifying the authenticity of products.

Market Dynamics:

Technological Advancements:

Ongoing advancements in spectrometry technologies enhance sensitivity, accuracy, and the range of applications, driving market growth.

Regulatory Compliance:

Stringent regulations in industries such as pharmaceuticals and food demand reliable analytical techniques, boosting the adoption of spectrometry.

Rise in Research and Development:

Increased research activities in pharmaceuticals, biotechnology, and environmental science contribute to the demand for advanced spectrometry techniques.

Globalization and Industrialization:

The expansion of industries globally, particularly in developing regions, increases the need for analytical techniques like spectrometry for quality control and compliance.

Challenges and Opportunities:

Cost and Accessibility:

High initial costs and the need for specialized expertise can be challenges. Opportunities lie in the development of cost-effective and user-friendly spectrometry solutions.

Miniaturization and Portability:

There is a growing demand for portable and miniaturized spectrometry devices for on-site analysis, creating opportunities for innovation.

Integration of Technologies:

Integration of spectrometry with other analytical techniques offers opportunities for comprehensive and efficient analyses.

Environmental Concerns:

The spectrometry industry is likely to benefit from increased focus on environmental testing and monitoring, addressing global environmental concerns.

[jcmarchi]

Machine Learning-Aided Non-Invasive Imaging for Rapid Liver Fat Visualization - Technology Org

New Post has been published on https://thedigitalinsider.com/machine-learning-aided-non-invasive-imaging-for-rapid-liver-fat-visualization-technology-org/

Machine Learning-Aided Non-Invasive Imaging for Rapid Liver Fat Visualization - Technology Org

The proposed framework, which is label-free and rapid, can enable an early diagnosis, treatment, and prevention of liver diseases.

Steatotic liver disease (SLD), previously known as non-alcoholic fatty liver disease, which includes a range of conditions caused by fat build-up in the liver due to abnormal lipid metabolism, affects about 25% of the population worldwide, making it the most common liver disorder.

Often referred to as “silent liver disease,” SLD progresses without noticeable symptoms and can lead to more severe conditions like cirrhosis (liver scarring) and liver cancer.

A liver biopsy―an invasive procedure involving liver tissue sample extraction from the body―is the conventional method of testing for SLD. To simplify detection, a research team led by Professor Kohei Soga of Tokyo University of Science (TUS) had previously introduced near-infrared hyperspectral imaging (NIR-HSI) as a non-invasive method to visualize the total lipid content in the liver.

NIR light, with longer wavelengths (800-2500 nm) than ultraviolet and visible light shows absorption attributed to various organic substances, including biomolecules in tissues, enabling the identification of fat distribution in the liver.

Now, in a new study published in the journal Scientific Reports, the research team, including Prof. Kohei Soga, Associate Professor Masakazu Umezawa, and Associate Professor Masao Kamimura from TUS, and Professor Naoko Ohtani from Osaka Metropolitan University, has improved upon this method by having a machine learning model differentiate the type of lipids present in the liver at a pixel-by-pixel level.

The framework differentiates lipids based on the hydrocarbon chain length (HCL) and degree of saturation (DS) of fatty acids, helping estimate the risk of SLD progression, steatohepatitis (NASH), and SLD/NASH-associated liver cancer.

“In addition to qualitative information, such as the total lipid content, we can now also visualize qualitative information, such as the characteristics of the distribution of fatty acids contained in lipids, mainly triglycerides,” says Dr. Umezawa.

Notably, identifying lipids based on molecular composition using NIR-HSI faced challenges due to the overlapping absorption spectra of various biomolecules. To address this, the researchers used a support vector regression machine learning model, which was trained to recognize the composition of 16 fatty acids.

This training data was obtained through gas chromatography analysis of liver samples of mice that were fed diets of varying fat content. By applying machine learning to NIR-HSI data, it became possible to interpret the spectral information in terms of the distribution of fat (DS and HCL) within the liver.

DS, indicating the double bonds or degree of saturation of the fatty acids, is calculated as the CH2 fraction from the sum of the CH and CH2 numbers. HCL, representing the fatty acid chain length, is determined by the ratio of CH3 + CH2 + CH + 1(COOH) groups to the number of CH3 groups.

Using this method, the researchers successfully determined the fatty acid composition in mice livers, revealing correlations with the fat contents in their diets. For instance, the livers of mice on a diet rich in saturated fats like palmitic acid and myristic acid exhibited a notably high DS, whereas mice fed with unsaturated fats such as α-linoleic acid showed a low DS.

The DS, HCL, and total lipid content were depicted as a color map, offering a unique visual representation of fat distribution in the liver, thus simplifying the diagnosis of fatty liver conditions. “Visualization of lipid distribution in higher-dimensional information rather than simply using total lipid content as a single parameter provides a novel tool for revealing the pathophysiological conditions of liver diseases and metabolism,” remarks Dr. Umezawa.

Indeed, by providing a rapid and label-free technique to identify fatty liver, which affects a large population segment, the method could be a potential alternative to invasive liver biopsy procedures, transforming liver care.

This novel framework could also find potential applications in pharmacological research, such as drug metabolism, toxicity, and efficacy; studies on metabolic disorders through metabolic imaging; and identifying responders and non-responders in clinical trials.

The researchers also expect the framework to find applications in identifying personalized nutritional strategies―tailoring plans and optimizing interventions for better nutrition―through biomarker identification and treatment response prediction. In summary, the novel framework developed by the researchers could revolutionize healthcare and related research.

Source: Tokyo University of Science

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[inphenix]

Explained: How Broadband Light Sources Have Advanced Spectroscopy?

In the past, discharging lamps, colour lasers and optical parametric oscillators were the only useful sources for spectroscopy. However, with the introduction of new technologies, spectroscopy has advanced to a new level. Supercontinuum lasers, light-emitting diodes, and laser-driven plasma technologies are new models of broadband light sources.

Because spectroscopy systems rely on light sources, new broadband light sources open up new opportunities for spectroscopists. Broadband light sources were only available for much of the last century.

However, a new generation of relatively sturdy broadband light sources is now gaining a place in the spectroscopist's toolset. From supercontinuum lasers, plasma sources driven by lasters, to Superluminescent diodes or SLEDs are now being used in spectroscopic applications.

Let's take a quick look at each of these three types of broadband light sources to see how they've advanced spectroscopy.

Supercontinuum Lasers For Spectroscopy

A supercontinuum is created when one or more spatial processes expand the frequency range of an electron beam. Depending on the medium in which the effect occurs, the processes underlying supercontinuum generation are diverse and complex.

These broadband light sources are analogous to broadband lamps that have been converted into lasers. These instruments' capabilities are put to use in spectroscopy in a variety of ways, including the development of novel mid-infrared absorption spectroscopy, optical coherence tomography, and visible cavity-enhanced spectroscopy setups.

Laser-Driven Light Sources For Spectroscopy

As previously stated, laser plasmas have been used as broadband light sources for spectroscopy in the past, but they have traditionally been found to be too unstable or weak to be useful for analytical spectroscopy.

This one-of-a-kind light source improves spectroscopy from near-infrared to ultraviolet wavelengths. As predicted by the reference work, Laser-driven broadband light sources have enabled numerous advances in the UV. For example, quantitative spectral analysis of biomolecules has been made possible using ultraviolet microscopy. Thanks to the ultraviolet wavelength, sub-cellular spatial resolution is possible.

Superluminescent Diodes For Spectroscopy

The most recent broadband light sources are superluminescent light-emitting diodes, which have only recently become available across a wide spectral spectrum.

The biggest problem with commercial LED lighting has been figuring out how to make both high-power, high-efficiency LEDs and colour blends that are appealing to the human eye.

The challenge in spectroscopy is different. Spectroscopists seek specific colors (ideally, tunable sources), high spectral purity or reproducibility, and high stability. LEDs face a unique challenge in terms of performance stability as a function of temperature. Accessing electronic transitions of environmentally significant gas molecules with UV sources has been a particular desire and challenge.

Summary: Lamps, traditional plasmas, globars, and the Sun are no longer the only broadband light sources. These applications range from ultraviolet to infrared. Consider one of these new sources the next time you're looking for a new application. Because of the combination of brightness, collimation, spectral range, and affordability, a new source could be your promising spectroscopic future.

Inphenix is a laser and light source manufacturer based in the United States that produces a variety of products such as O-band optical amplifiers, distributed feedback lasers, broadband light sources, VCSELs, and swept-source lasers. Visit their website to find out more about their high-quality products and services.

[pinersale]

Blueprint pro unit for red light therapy

Low-intensity light research has revealed that specific wavelengths of light in the visible and near visible spectrum (at the correct dose, intensity, and pulse frequency) can induce a variety of cellular effects in some nonphotosynthetic cells. In this way, visible and near visible light provides the energy for the production of high-energy molecules and influences the reduction/oxidation (redox) state of the cell. This electron transport also influences the reduction and oxidation of biomolecules associated with the electron transport chain (i.e., the production of associated ROS). This electron transport is used to create the proton motive force and thus generates energy for the cell. Subsequent photoexcitation is tightly linked to biomolecular electron transport, which in essence involves the oxidation and reduction of biomolecules in the chain. Plant life utilizes biomolecular photoacceptors to absorb this energy. Photosynthesis is dependent upon the absorption of photon energies from the visible and near visible spectrum. 2 In plants, the chloroplast is a major source of ROS, produced by photostimulation of the chloroplast electron transport chain. In certain cell types, they have demonstrated their effect on cellular function, in particular as growth regulators. In higher concentrations they can be cytotoxic however, in lower concentrations they are now being appreciated as important signaling molecules. These ROS alter the cellular redox state. 1 ROS are largely produced as oxidative metabolism byproducts of the mitochondria. Understanding the role of redox state and signaling in LILT may be useful in guiding future therapies, particularly in conditions associated with pro-oxidant conditions.Ĭ ellular redox state is the delicate balance between the levels of reactive oxygen species (ROS) produced during metabolism and ROS scavenged by the antioxidant system. In this manner, LILT may act to promote proliferation and/or cellular homeostasis. It seems that visible and near visible low-intensity light can be used to modulate cellular physiology in some nonphotosynthetic cells, acting through existing redox mechanisms of cellular physiology. In gene therapy research, ultraviolet lasers are being used to photostimulate cells through a process that also appears to involve redox signaling. In plants, photostimulation of the analogous photosynthetic electron transport chain leads to redox signaling known to be integral to cellular function. Redox mechanisms are known to be involved in cellular homeostasis and proliferative control. In some cells, this process appears to participate in reduction/oxidation (redox) signaling. Although the underlying mechanisms have not yet been clearly elucidated, mitochondrial photostimulation has been shown to increase ATP production and cause transient increases in reactive oxygen species (ROS). The mitochondrial electron transport chain has been shown to be photosensitive to red and near-infrared (NIR) light. Low-intensity light therapy (LILT) appears to be working through newly recognized photoacceptor systems.