#the antibiotics

[firelord-frowny]

yall these last several days have been THE! WORST!!!!

or idk, not the worst lmao i tend to try to save catastrophic language for actual catastrophes these days and since nobody is dead or maimed, i guess "really really sucked" is the better way to describe it.

but anyway. it really really sucked so bad that i dont even feel like properly ranting about it, so here's a bulleted list of the suckage. -Had (probably) the flu for like two weeks. Missed two weeks of volunteering and one week of work. -Felt better! Volunteered. Went to work. -Throat got sore in the middle of the night. like i literally FELT it get sore in real time. felt it swell. -Sore throat morphed to include an ear ache. -Also felt nauseous several times throughout the day. -went with my mom to go pick up groceries and also one single item to hopefully expedite my recovery (those lil emergen-c supplement drink packets) and somehow wound up getting yelled at about what an inconvenience it is to ~have~ to make a 20 minute round trip to pick up groceries that included something for me🙃 i literally would have just done an instacart order like i usually do but we already needed groceries and that is the only reason i put it in the grocery order so i guess that somehow means that its My Fault the household needed groceries and i guess a 20 minute trip is the worst fucking thing a person can be bothered to do on a sunday afternoon. i mean nevermind the asparagus and the yellow squash and the cornbread mix and the condensed milk and the walnuts and the clam strips and the bananas and the whole grain cereal and the canned vegetables and the frozen berries and all the other shit that aint have JACK to do with me, bc my vitamin c supplement made all of that moot and the sole reason for going to get groceries was because im a needy piece of shit whose better off idk dying of meningitis or soemthing, idfk.

-had a virtual ~urgent care~ visit. got prescribed antibiotics for what's probably a sinus infection gone nuclear. that was yesterday.

-today! throat still hurt like a bitch. couldn't really eat or drink much but I had an apple and some water before taking a dose of ibuprofen.

-went to work. started getting a migraine on the way. benadryl often takes the edge off of my migraines so my dad (who was giving me a ride to work) agreed to swing by a store and pick some up after dropping me off at work, and then swing back and bring me the meds.

-HOWEVER! you know what the first thing i did upon pulling into the parking lot at work was?

-puke. A LOT. big ol pile of puke in the parking lot. disgusting.

-called the front desk and let them know that i in fact made it to work but that i just vomited my guts out in the parking lot and should probably go home. they were like, "yikes, yeah, definitely go home, please feel better soon" and canceled all my students for the day. I'm Extra Upset by this bit because 2 of my students have missed a lot of lessons recently (one because they were on vacation, another because there were no lessons on 4th of july, another because a different student canceled, and one because i was sick) and i really really really want to keep as much consistency as possible both for the student's progression, and for increasing my chances that they'll keep me as a teacher. and i also had one new adult student that i saw for the first time last week and am super bummed that i already had to throw a wrench in his new experience learning an instrument.

anyway,

-throat was still hurting like a BITCH and i obviously needed to eat and drink especially since i THREW THE HELL UP EARLIER so i made another virtual urgent care appointment.

-got through the entire intake process as far as submitting all the forms. all that was left was for someone to call me and confirm all the info.

-i get the call! confirm the info! the lady says she'll send me a link to the visit as soon as we hang up.

-BUT THEN she asks me if i'd had a virtual visit the day before for the same reason, and i said yeah! and then she says! that i can't have a virtual visit because blah blah blah they cant do telehealth appointments for one patient for the same reason in less than 7 days! which like! ok i guess but PERHAPS THAT COULD HAVE BEEN POINTED OUT WHEN I SELECTED THE REASON IN THE INTAKE FORMS 15 MINUTES AGO???

-but whatever! okay fine! so i made an appointment for the in person clinic and was able to be seen relatively quickly.

-everybody was super nice (literally all of the medical people i've dealt with over the last two days have been super nice) and one of the desk ladies told me i have a "really sweet voice" and that made me Happyyyy and so i told her how happy it made me and that it meant an extra lot because i used to have a violin teacher who would tell me my voice was annoying and the lady was like "omg wtf" and i was like "i know right? i was like 13" and she's like "daaaaang wtf!' and im like RIGHT???

-even though i was able to be seen relatively quickly it still took kind of a long time for the nurse practitioner herself to get to me, but once she did, it was smooth sailing from there. covid, flu, and strep tests were negative. prescribed me prednisone for the sore throat. took my first dose in the clinic. picking up the rest of it from a pharmacy tomorrow.

-its now 3am as i type this and my throat is feeling significantly better. took my 3rd dose of antibiotics earlier tonight, along with some tylenol, since apparently ibuprofen can have some reactions with prednisone, and since my throat at that moment was still pretty sore. but i think by now i can finally EAT SOMETHING so thats what imma do, and then imma *samuel l jackson voice* Go The Fuck To Sleep.

[pangur-and-grim]

this seems to be what we're doing, everyone is having a turn being The Sick One with this URI

[froody]

child mortality rates were so high in the 1840s and 1850s that when I see record of someone who’s (documented) children all survived into adulthood I’m like “wow. how the fuck did you do that.”

also there is this idea that parents just cared less about their children back then because they died so often but the many many many accounts of mothers and fathers holding their gravely ill children all night not sure if their next breath would be their last. that loss was the greatest fear then just as it is now and just as it seemed to be in Paleolithic times. they compartmentalized their grief to survive but that didn’t mean they felt it any less keenly.

[reasonsforhope]

"When bloodstream infections set in, fast treatment is crucial — but it can take several days to identify the bacteria responsible. A new, rapid-diagnosis sepsis test could cut down on the wait, reducing testing time from as much as a few days to about 13 hours by cutting out a lengthy blood culturing step, researchers report July 24 [2024] in Nature.

“They are pushing the limits of rapid diagnostics for bloodstream infections,” says Pak Kin Wong, a biomedical engineer at Penn State who was not involved in the research. “They are driving toward a direction that will dramatically improve the clinical management of bloodstream infections and sepsis.”

Sepsis — an immune system overreaction to an infection — is a life-threatening condition that strikes nearly 2 million people per year in the United States, killing more than 250,000 (SN: 5/18/08). The condition can also progress to septic shock, a steep drop in blood pressure that damages the kidneys, lungs, liver and other organs. It can be caused by a broad range of different bacteria, making species identification key for personalized treatment of each patient.

In conventional sepsis testing, the blood collected from the patient must first go through a daylong blood culturing step to grow more bacteria for detection. The sample then goes through a second culture for purification before undergoing testing to find the best treatment. During the two to three days required for testing, patients are placed on broad-spectrum antibiotics — a blunt tool designed to stave off a mystery infection that’s better treated by targeted antibiotics after figuring out the specific bacteria causing the infection.

Nanoengineer Tae Hyun Kim and colleagues found a way around the initial 24-hour blood culture.

The workaround starts by injecting a blood sample with nanoparticles decorated with a peptide designed to bind to a wide range of blood-borne pathogens. Magnets then pull out the nanoparticles, and the bound pathogens come with them. Those bacteria are sent directly to the pure culture. Thanks to this binding and sorting process, the bacteria can grow faster without extraneous components in the sample, like blood cells and the previously given broad-spectrum antibiotics, says Kim, of Seoul National University in South Korea.

Cutting out the initial blood culturing step also relies on a new imaging algorithm, Kim says. To test bacteria’s susceptibility to antibiotics, both are placed in the same environment, and scientists observe if and how the antibiotics stunt the bacteria’s growth or kill them. The team’s image detection algorithm can detect subtler changes than the human eye can. So it can identify the species and antibiotic susceptibility with far fewer bacteria cells than the conventional method, thereby reducing the need for long culture times to produce larger colonies.

Though the new method shows promise, Wong says, any new test carries a risk of false negatives, missing bacteria that are actually present in the bloodstream. That in turn can lead to not treating an active infection, and “undertreatment of bloodstream infection can be fatal,” he says. “While the classical blood culture technique is extremely slow, it is very effective in avoiding false negatives.”

Following their laboratory-based experiments, Kim and colleagues tested their new method clinically, running it in parallel with conventional sepsis testing on 190 hospital patients with suspected infections. The testing obtained a 100 percent match on correct bacterial species identification, the team reports. Though more clinical tests are needed, these accuracy results are encouraging so far, Kim says.

The team is continuing to refine their design in hopes of developing a fully automated sepsis blood test that can quickly produce results, even when hospital laboratories are closed overnight. “We really wanted to commercialize this and really make it happen so that we could make impacts to the patients,” Kim says."

-via Science News, July 24, 2024

[tinypaperhats]

Love that mineru can walk in with you at the blademaster’s exam cave.

[spidehpig]

my fever induced thoughts about bird is horny & ovulating x mean bastard ghost

mostly just rambling, didn’t check for coherency or grammar. i’ve been plagued by these thoughts and just had to get them out sorry.

ghost x reader

mean bastard ghost with a bird who’s been so needy and clingy all day long. he’s not really sure what’s got her panting and gagging for his cock like a whore, must be a cycle thing. either way he doesn’t mind, in fact he finds it amusing. he’s so used to just indulging himself, parting her thighs with his meaty hands and swiping his tongue along her folds as her little squeals and protests fall on deaf ears.

it’s not everyday that he’s the one to wake up to her trying to take what she needs from him. her pretty moans shaking away the last tendrils of sleep from him as the wet cotton of her panties rut against his thigh and her other hand gropes at his cock straining against his boxers. he has half a mind to push the greedy brat onto her belly and just mount her right there. but this unashamed desperation radiating from his bird is a rarity he’ll indulge in.

he feels a little sick satisfaction when her sweet moans break off into a frustrated little cries as his fist clamps around her waist, halting the desperate little grind of her hips. ignores her begging and pleading as he slips from the sheets. leaves her aching and wanting as she trails into the shower after him with a cute little pout.

keeps his face stoic as he pinches and flicks at her swollen nipples, his other hand pawing at her ass. working her up into a frenzy again, makes sure she can feel his heavy cock throb against her thigh as he cups her dripping cunt. thick fingers bullying their way between her lips under the guise of washing her clean. likes the way she shivers and bucks against him when his knuckle brushes across her clit. he quickly twists the rusty shower handle when she reaches for his cock again and huffs out a raspy laugh when she squawks at him as the shower water turns to ice. doesn’t look back as he steps out and tosses a towel at her.

maybe he shouldn’t punish his little bird’s confidence and needy demands. it’s not every day he wakes up to her wet and willing, so eager to milk his cock. but he has the time and patience today. maybe it’s boredom from such a long leave or maybe he’s just a bastard he thinks as he pulls her onto his lap later as he watches the game. fingers sneaking under the fabric of her tank top to pinch and twist at her nipples until she’s squirming in his lap searching for the friction of his hard cock. waits until she’s panting and whining again before pushing her off his lap a grunting at her to go fix dinner. gives his cock a couple of lazy tugs as she shoots him a dirty look and stumbles into the kitchen on unsteady legs.

later ducks his head under the kitchen doorframe to corner her against the counter to paw and grope at her pretty hips, feels the soft skin of her inner thighs are still slick. pulls back the second she sighs and arches back against him. he ignores the way she glares at him across the table as he shovels the dinner she made him into his mouth. and just to be a prick, finishes his game after dinner while she angrily slams the dirty dishes around in the kitchen.

waits until she’s finished until he prowls off into the bedroom and lights a cigarette as he settles against the pillows. sprawled out across the center of the bed, he finally shoves the waistband of his sweats under his balls to let his heavy cock spring free. precum already leaking onto his thigh as he barks at his bird to come take care of this.

can’t help but smirk as she hesitates in the doorway. unsure if this is just another one of his cruel tricks after he had spent all day teasing her. fists his cock and tells her to come take what she needs. almost barks out a laugh as her eyes widen and she quickly wiggles out of her panties and scrambles up onto the bed. licks his lips when he gets a glimpse of her already glistening cunt as she crawls up over his hulking body. has half a mind to stub his smoke out and sit her over his hungry mouth. instead he takes another drag as her thighs stretch wide on either side of his thick waist to hump her slick cunt along the underside of his cock.

he makes no move to touch her as she ruts and humps against his cock, the bed already creaking with her frantic movements. only pausing to grit his teeth as the tip of his cock catches on her warm hole as she rocks backwards again. lights up another smoke as she leans back onto her haunches to bury two fingers into her cunt when it becomes apparent he won’t be doing anything to help satiate her needs. pupils blown as he watches her sloppy cunt swallow her little fingers. not at all enough to prep her for his cock.

she doesn’t seem to care as she lurches forward and her nails dig into the fat of his chest as she rises up onto her knees, reaching back as she pathetically tries to line his leaking cock up with her cunt. her little grunts of frustration are music to his ears as she struggles to catch the tip on her hole again. movements faltering and sputtering a little when he blows smoke in her face. sweat glistening along her brow when she glares at him and finally manages to sink down a few inches.

his eyes roll back with how tight she is, half expects her to stop and beg him to finger her open. instead she grunts in pain and tries to bounce and wiggle her way down onto his prick. barely any leverage with the way she’s already risen so far up onto her knees just to straddle his thick waist, the cushioned mattress does nothing to ease her struggle. and fuck, watching her buck and bounce just to bully his fat cock into her greedy cunt is tearing at the remains of his control.

it’s not until her walls finally relax and she sinks down onto his cock with a yowl that he finally acknowledges her. cooing and taunting her for being such a needy slag, drooling over his cock all day long. watches the way a sob wracks through her body as her hands grip at the fat of his stomach trying to get some leverage to push herself up on his cock. barely manages to rise up a few inches before she’s letting out a frustrated sob and instead just grinds back and forth on his lap with his cock buried in her cunt, so pathetic.

she yelps when he slaps her tit and growls at her to ride him proper. sniveling after his cock all day long and she can’t even take it right? he decides he’ll let her whine and mewl and beg him to just take her as she grinds on top him. she can’t even take what she needs. maybe when she finally collapses from exhaustion will he flip her over and breed her pretty cunt. seems like he’s the only one that can give her what she needs after all.

[theshitpostcalligrapher]

Guesss who got reinfected with strep throat???

[musubiki]

🎂 birthday time 🎂

[salt-baby]

POTS Medication Vocabulary

after about the third time a doctor prescribed a medication that made my POTS drastically worse, and about three doctors visits past giving up on being an easy patient, i started asking my doctors the following questions whenever they prescribed a new long term medication:

is this medication a hypotensive? (will this medication lower my blood pressure?)

does this medication have a risk of tachycardia? (can this medication raise my heart rate?)

is this medication a diuretic? (will this medication dehydrate me?)

can this medication cause hyponatremia? (will this medication cause my body to lose salt?)

your doctor likely doesn’t know all of this off the top of their head for every medication, but they should know the most common adverse reactions. some may simply tell you they have no clue. i still think it’s worth asking to force them to consider these mechanisms.

for additional consideration:

your pharmacist likely knows the answers to these questions better than your doctor does. 

an additional list of types of drugs which should be avoided is available here, in the table on the fourth page. (note that propranolol, a beta blocker, is often prescribed for POTS but is discouraged by this paper. as someone whose taken it, it’s worth trying to see if it will improve symptoms, but didn’t for me. Additionally, these are just guidelines, and in those with, for example, both hEDS and POTS, the benefits of opiates for pain relief may be worth the risk of worsening POTS.)

regardless of what the doctor says, I always look up the FDA info sheet before taking a medication. these can be found pretty easily on google (your med + “fda pdf”), and list most of the adverse effects. I’m happy to make a post about reading these info sheets.

there’s a reason prescribing medication is left to those with years of medical training - it’s a complicated and difficult process. but oftentimes those who do this work are so overworked and burnt out, they don’t have the ability to read someone’s entire medical file, or be aware of an adverse event that only affects those with an uncommon condition. I find asking these questions forces my doctors to think about my chronic conditions, and after so many adverse events, I always check a medication for myself before taking it. 

remember that you can and should refuse to take a medication that is making your life worse or harming you. even pediatric patients have the right to refuse a medication, and often times, I’ve found nothing other than a very firm “no, I refuse” will get a doctor to consider other options. and even though its against the norm, remember that you have the right to ask your doctor why they’ve chosen that medication for you.

as always, feel free to ask questions, they make my day!

[moki-dokie]

furries would not be where they are today if not for dragoneer. even before he created FA, he was carving out spaces where the tiny niche that were furries could feel safe and have fun. one dude. you can trace practically every modern furry community back to one individual guy and the relentless work he did. given how tied to the lgbt+ community furries have become, i sincerely hope his name is one that becomes immortalized in queer history. what a fucking legacy.

[pangur-and-grim]

I’m so happy that he’s on antibiotics. tiny kittens should never be allowed to get sick

[foxett]

The 5 rw group making flower crowns post game ? :3

Hey guys i bring the

[mindblowingscience]

Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, a common and dangerous hospital-associated bacterial infection, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture. The findings are detailed in the journal Nature. "People are starting to realize that the antibiotics we've all been taking—that are fighting infection and, in some instances, saving our lives—also are having these deleterious effects on us," said University of Illinois Urbana-Champaign chemistry professor Paul Hergenrother, who led the study with former doctoral student Kristen Muñoz.

Continue Reading.

[reasonsforhope]

"An international research team has found almost a million potential sources of antibiotics in the natural world.

Research published in the journal Cell by a team including Queensland University of Technology (QUT) computational biologist Associate Professor Luis Pedro Coelho has used machine learning to identify 863,498 promising antimicrobial peptides -- small molecules that can kill or inhibit the growth of infectious microbes.

The findings of the study come with a renewed global focus on combatting antimicrobial resistance (AMR) as humanity contends with the growing number of superbugs resistant to current drugs.

"There is an urgent need for new methods for antibiotic discovery," Professor Coelho, a researcher at the QUT Centre for Microbiome Research, said. The centre studies the structure and function of microbial communities from around the globe.

"It is one of the top public health threats, killing 1.27 million people each year." ...

"Using artificial intelligence to understand and harness the power of the global microbiome will hopefully drive innovative research for better public health outcomes," he said.

The team verified the machine predictions by testing 100 laboratory-made peptides against clinically significant pathogens. They found 79 disrupted bacterial membranes and 63 specifically targeted antibiotic-resistant bacteria such as Staphylococcus aureus and Escherichia coli.

"Moreover, some peptides helped to eliminate infections in mice; two in particular reduced bacteria by up to four orders of magnitude," Professor Coelho said.

In a preclinical model, tested on infected mice, treatment with these peptides produced results similar to the effects of polymyxin B -- a commercially available antibiotic which is used to treat meningitis, pneumonia, sepsis and urinary tract infections.

More than 60,000 metagenomes (a collection of genomes within a specific environment), which together contained the genetic makeup of over one million organisms, were analysed to get these results. They came from sources across the globe including marine and soil environments, and human and animal guts.

The resulting AMPSphere -- a comprehensive database comprising these novel peptides -- has been published as a publicly available, open-access resource for new antibiotic discovery.

[Note: !!! Love it. Open access research databases my beloved.]"

-via Science Daily, June 5, 2024

[slouchingbeast]

INJECTED for my crimes

[lizziestudieshistory]

Someone send help, this is my "currently reading" pile and I'm fearful it's going to topple over if I keep going at this rate! Worst part is this isn't a complete picture of how out of control I am because I'm reading two fantasy books on my Kobo!