#some method of induced immunity

[spiribia]

in this universe werewolves are a union between a demon and a human host. with more powerful demons the host is often parasitized to the point of being just an empty human husk containing a demon, but some lesser or benevolent demons have more amicable arrangements, and some by-technicality-werewolves even have demons that only tag along and see the world through your eyes (these cases are considered werewolf 'immune'. when a werewolf bites you and transmits its venom into your bloodstream, the venom acts a beacon for demons to locate your body. they won't take over a human host that's already occupied by another demon, though, so in many cases having a lesser demon prevents any more aggressive demons from trying anything). anyway youre a werewolf hunter chasing down signs of a mark at some club and your assigned werewolf hunter partner whos clearly "not" a "werewolf" is really dragging her feet for this one and you notice some dude thats clearly charming people and devouring them in the back alley and your partners like Dont go back there. lets just forget about this one and youre like What but this is the mark isnt it. the whole point of us being here is to stop it. & then it turns out its some actual demon lord.

[covid-safer-hotties]

Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes - Published July 29, 2024

You read that right: Covid infections can result in AIDS. I've been following this preprint since 2022, and I'm so excited to see it finally published! You might remember the preprint from the original Milf-Adjacent or covidsafehotties blogs.

Highlights •Genotypes N/120 and N/152 of SARS-CoV-2 have been identified in the acquired immuno-deficiency scope caused by Sarbecovirus.

•A new binding site for the Sarbecovirus N protein is proposed as the main route of infection of lymphocytes through CD147 receptors.

•Immune dysregulation caused by infection of CD147 lymphocytes is consistent with clinical data of severe and Long Covid cases.

Abstract Background Epigenetics and clinical observations referring to Betacoronavirus lead to the conjecture that Sarbecovirus may have the ability to infect lymphocytes using a different way than the spike protein. In addition to inducing the death of lymphocytes, thus drastically reducing their population and causing a serious immune deficiency, allows it to remain hidden for long periods of latency using them as a viral reservoir in what is named Long-Covid Disease. Exploring possibilities, the hypothesis is focused on that N protein may be the key of infecting lymphocytes.

Method The present article exhibits a computational assay for the latest complete sequences reported to GISAID, correlating N genotypes with an enhancement in the affinity of the complex that causes immune deficiency in order to determine a good docking with the N protein and some receptors in lymphocytes.

Results A novel high-interaction coupling of N-RBD and CD147 is presented as the main way of infecting lymphocytes, allowing to define those genotypes involved in their affinity enhancement.

Conclusion The hypothesis is consistent with the mutagenic deriving observed on the in-silico assay, which reveals that genotypes N/120 and N/152 are determinant to reduce the Immune Response of the host infecting lymphocytes, allowing the virus persists indefinitely and causing an Acquire Immune Deficiency Syndrome.

Graphical abstract

[rallamajoop]

Resident Evil 7 Ending Text

The ending sequence of RE7 features panning shots of a document containing various photos and text about the project that created Eveline. The text repeats every few paragraphs (often several times in the same image), but it does include some interesting details about Eveline that don't show up elsewhere in the game.

A few lines of the same text even show up again on the side of the Rose flasks in RE8 ‒ Recently deceased. Procedure is untested and early subjects were destroyed too quickly to collect definitive data ‒ and elsewhere, If injections are skipped for prolonged periods of time, the product will age rapidly... (If you have really good eyesight, you might even notice this snippet continues underneath the 'Stabilising Compounds' header.)

But the complete text from RE7 is much longer. I've stuck what I could patch together from the ending sequence under the cut.

The product is a bioweapons commodity created by the Bioweapons Division. It takes the form of a child (in this case a girl named Eveline) which can be purchased and raised to suit individual client needs. Its purpose is mind control — up to and including inducement to violence. Application can vary from political to military to economic destabilization. Method of inducement: chemical transference of psychotropic compounds via skin to skin contact between Product and Subject inducing a mentally suggestive state in the subject responsive only to the product. Known dangers: The Product is currently in the prototype stage and is both mentally and physically unstable requiring regular maintenance injections of stabilizing compounds. If the injections are skipped for prolonged periods of time the Product will age rapidly — 25 Xs faster than normal. Eventually the Product will become insane and a danger to all around it. No tests have been run on subjects depriving them of maintenance chemicals for more than 6 months as the situation became too dangerous for observation. The Product also affects its environment mutating plants and promoting the growth of a highly toxic psychotropic mold, the ingestion of which causes insanity and severe mutations in those who ingest it. There is some indication the use of the mold could revive the recently deceased. However, this has yet to be tested. Early subjects were destroyed much too quickly to collect definitive data on this. Product should ship with a minimum of two Handlers each with serum immunizing them to the Products mental control as well as Stabilizing Compounds. Handlers should be equipped with equipment tuned to Product's biochemisty. One of the Handlers should imprint on the Product as a close relative, either as a mother or as a father figure. This will aid in controlling during field operations. Product is ready for field testing which should be initiated as soon as possible. Suitable clients exist in the Americas, and one should be selected ASAP for test delivery.

Among the more interesting details is that bit about having a handler 'imprint on the Product as a close relative', which is made to sound like it's simply a part of transport procedure ‒ just another thing for handlers to be equipped with. I'd assumed the 'imprinting protocol' Mia refers to in the game meant she must have been involved with the project that created Eveline from early on, but this makes it sound like part of a pre-departure checklist. Could Mia have met Eveline and been 'imprinted' only shortly before they left?

Far creepier is the loud implication that the 'parental' bond of handler to 'Product' would 'aid in controlling during field operations'. Mia gets an awful rap around this fandom, but it's hard to imagine she'd be happy being shipped off as Eveline's permanent field-handler to some foreign government or terrorist organisation ‒ especially given how eager she is to be done with her "babysitting job." But once Eveline was past the 'prototype stage', that sounds like exactly what the Connections intended for handlers like her to do.

Then there's the bit about giving handlers a "serum immunizing them to the Products mental control," which could certainly explain how Mia was able to resist for so long, and is presumably the same agent the Connections supplied to Lucas (I wonder if Zoe ever got her hands on some?) Must be a different serum to the one that actually cures you of the mould, however, since Lucas pretty clearly isn't cured.

Also: There is some indication the use of the mold could revive the recently deceased. However, this has yet to be tested. Early subjects were destroyed much too quickly to collect definitive data on this. Yeah, I'd say that one's been pretty well tested by the end of RE7!

As for that part about Eveline aging 25x faster than normal if not regularly injected with the stabilising compound, the numbers add up surprisingly well! Eveline escaped in October 2014. By September 2016, when Lucas reports she's showing grey hairs, she'd have aged around 2x25=50 years, making her apparent age close to 60. By Ethan's arrival in July 2017, that's 2 years and 9 months, or almost 70 extra years of aging, for total of 80 years old.

Yeah, looks about right to me.

Getting back to RE8, what does it mean that some of this text was reused on the side of the Rose flask? All that stuff about rapid aging clearly applies to Eveline, but seems completely irrelevant to baby Rose.

Much like the RE7 ending, I don't think the text is meant as much more than a bit of convenient lorem ipsum-style filler material ‒ though the fact she's labeled EVE No. 3 is obviously a reference to the project that created Eveline (and yes, the same number appears on all four flasks ‒ it's not a flask number). Which raises the question: who were 1 and 2? Eveline's referred to as E-001, so could 2 be the other member of the E-series we see being killed in necrotoxin tests in the lab photos? Or was Eva 1 and Eveline 2, by Miranda's reckoning? Were these flasks previously used to hold the remains of a previous E-series member tagged E-003?

It's not like it's essential lore or anything, but it'd be interesting to know which version was on the mind of whoever created that asset all the same.

[valleyfthdolls]

New Mr. Hopp Demonology Post, Because I Seem to Have Lost the Last One

What is the Entity? (Excluding Satan, because that's lame)

Looking at the Ars Goetia, the Dictionnaire Infernal, the Pseudomonarchia Daemonum for demons here, we have roughlyyyyy

Ninety demons, give or take? 72 from both and 12 exclusive to the Pseudomonarchia Daemonum, plus all the ones exclusive to the Dictionnaire Infernal. I'm done counting. So how do we go about this? We see its trademarks- what the Entity is associated with, what its powers are, its modus operandi, and its power level in the underworld, and we compare it to those eighty-nine demons. We have a wide variety, but with this method, we can eliminate large numbers in one fell swoop.

So, what are the Entity's trademarks?

Well, according to the wiki, its powers include- excluding the ones that make no sense like "age changing" and "mouth orbs"- supernatural strength, teleportation, manifestation, telekinesis, dream and mind manipulation, future vision, curses, possession, and the ability to induce hallucinations. Its association is mostly with the things it controls (Mr. Hopp's music box, Isabelle's burning death, etc.), but what I will call to mind here is the number three- the three toys it puppets, the three girls it hunts with varying levels of success, and the Six, with six being a multiple of three (I know, it's a stretch). Its modus operandi- how it enacts its whims- seems to be through children, and mostly through little girls. (ew.)

It takes emotionally vulnerable children (Isabelle, a troubled child who I suspect may have- very big may have- been an orphan living in a Christian almshouse in the 1560s, Esther, who was an orphan living in an abusive orphanage who I thought had lost her parents to war, but I guess not, and Ruby, who had recently lost her beloved Nana) and preys on those feelings of pain and alienation, promising them "luxury and comfort"- through the powers of The Six, I assume this to be powers such as telekinesis, manifestation, knowledge, and protection/immunity/immortality. It then takes these children to the underworld to feed on their souls, likely for power.

Also worth noting is that it leads armies in the underworld and is of a high rank. Not worth noting is that it is a fallen angel and "the embodiment of sin and evil in many cultures"- not only because I'm forgoing the Satan approach but also because the former is true of all demons and the latter is... vague, at best, and factually incorrect with regards to Satan at worst.

So looking at that, we need a high ranking demon who promises "luxury", eternal life and protection, preys on children, possesses people, is associated in some capacity with the number three, can manifest things (spirits, objects, whatever), and either has a goat head and/or numerous legs or can shapeshift.

The two closest candidates for the Entity include:

Bael- three headed, numerous legs, shapeshifting, yellow snake eyes according to one source, king of hell, potential child sacrifices (VERY disputed), offers wisdom, invisibility and invincibility, has a hoarse voice, one source says he can induce nightmares, appears in dreams, can possess people

Paimon- two subordinates, hoarse voice, knowledge of past and future, manifestation, inducing visions (hallucinations), reanimating the dead, heralded by music, king of hell, can possess people

Between these two, which one is most likely to be the Entity?

Well, I think it's Bael.

While Paimon's two subordinates call to mind Miss Bo and Mr. Stripes and his ability to induce visions and manifest things is similar to the Entity, the unique parallels end there. Paimon is loyal to Lucifer, and the Entity is independent. To summon him, it's believed that you need to make him an offering- opposite to the Entity, who offers Isabelle the Six. Paimon is depicted as a human riding a camel, as opposed to anything goatlike, and the Entity's music- first of all, a music box, not trumpets like the ones Paimon is heralded by- is only a product of its control of the Mr. Hopp doll.

The Entity is a shapeshifter whose "monster form" has four to six legs, with yellow snake-like eyes, who offers wisdom and invincibility, has a hoarse voice, induces nightmares and appears in dreams. It takes over children, burns them, and rules over hell just like Bael. There's actually no proof that Miss Bo and Mr. Stripes are controlled by any separate entities- in fact, it's more likely that they're all controlled by the same one, making Paimon's subordinates irrelevant. What it does call to mind, however, is Bael's three heads. One for each toy it controls.

And very notably about those toys, when they merge into one in the end of Mr. Hopp's Playhouse 2, the amalgamate has those signature three heads.

But the cherry on top, I think, is the fact that not one but three of the sigils of the Six bear a resemblance to Bael's sigil. Now, all of the Six are exceedingly simple for sigils, I'll come right out the gate and say that, but notably, three of them feature stylized X shapes, which each resemble the sigil of Bael.

The Entity is the sole ruler of the Underworld, like some stories say Bael was at one point, but maybe the other sigils represent angels of some kind? After all, we do know of at least three angels (Esther, the Entity pre-banishment, and whatever banished the Entity) but when we traverse the Underworld, there's only one demon and a bunch of human spirits. And the Six are meant to represent balance, so having three of them worn, used, and corrupted by Bael and the other three for the light powers utilized by Esther to ward off its evil.

TLDR; it's Bael.

[coochiequeens]

First purchasing parents exploit women to have their kids then they exploit women who are able to donate their milk.

Challenges of Breastfeeding Surrogate Babies: Overcoming the Hurdles

By Harriet Collins- 2023-08-22

Top Takeaways

Breastfeeding is a natural process that provides babies with essential nutrition and protects them from infections and diseases.

It helps create a bond between mother and child.

Babies should be exclusively breastfed for the first six months of life.

Surrogacy can pose challenges for breastfeeding, but induced lactation is possible for intended mothers.

Induced lactation recreates the process of breastfeeding and requires advanced preparation.

Breastfeeding is not a choice but a necessity for the good immunity of future generations. Lack of awareness about breastfeeding in surrogacy cases can be a barrier. Intended mothers can lactate and breastfeed their surrogate child.

Quoting a recent article on WIONews, breastfeeding surrogate babies can be challenging, but it is possible. Breastfeeding is a natural and beautiful process that provides babies with all of their nutritional needs and helps create a bond between mother and child. However, some mothers may choose alternative feeding methods such as formula feeding.

Babies can start breastfeeding within the first hour of birth and should be exclusively breastfed for the first six months of life. During this time, no other foods or liquids should be provided, including water. This is important for the baby’s growth and development, as breast milk protects them from infections and diseases.

However, the journey of pregnancy and childbirth is not the same for everyone, and mothers may face numerous challenges. One such challenge is surrogacy, where a woman carries and gives birth to a baby for another person or couple. Surrogacy can be a complex legal and ethical process, and regulations vary by country and jurisdiction.

When it comes to breastfeeding a surrogate baby, it is crucial to carefully consider all aspects and legalities before pursuing surrogacy. However, it should not be a hurdle for the baby to receive basic needs, such as breast milk.

Dr. Manpreet Sodhi, a Consultant in Obstetrics, Gynecology, and Art at Paras Health in Gurugram, explains that intended mothers can lactate and breastfeed their child even without experiencing pregnancy. This is possible through induced lactation, which recreates the process of being able to breastfeed gradually and requires advanced preparation.

Dr. Yashica Gudesar, a Consultant in Obstetrics and Gynaecology at HCMCT Manipal Hospital in Dwarka, emphasizes the health benefits of breastfeeding and notes that it is a necessity for the good immunity of our future generation. In cases of surrogacy, lack of awareness sometimes becomes a barrier to lactation, as doctors and patients may not be aware that lactation is possible in such mothers.

Breastfeeding a surrogate baby is similar to nursing a newborn, and it is essential to provide the baby with the best start in life. Breast milk provides numerous benefits for the baby’s health and well-being, and it also helps strengthen the bond between the mother and child.

In consideration of all these factors, while breastfeeding surrogate babies may present challenges, it is possible through induced lactation. Intended mothers can prepare themselves for breastfeeding and provide their babies with the nutritional and emotional benefits of breast milk. It is important for healthcare professionals and patients to be aware of this possibility and to provide support and guidance to ensure the best outcomes for both mothers and babies.

Milk Banks are supposed to benefit sick babies or babies who lost their mother. Now families, wether that be a hetro couple or two non-women, that were able to exploit a woman for a bio baby could be taking from the supply that families in temporary crisis are dependent on.

[tasharoseorganics]

Why Organic Elderberry Syrup is a Must-Have for Immune Support

Why Organic Elderberry Syrup is a Must-Have for Immune Support

Why Organic Elderberry Syrup is a Must-Have for Immune Support

Let’s get right to the point. Shall we? Elderberry has been scientifically proven to support the activation of the immune system and prevent the replication of viruses, as well as being active against bacteria. Full stop. Do you need to read that again? Elderberries have some pretty amazing benefits. It’s no wonder I always have a bottle of our organic Elderberry Syrup in the fridge for the first sign of sniffles or scratchy throat. In addition to all the modern research, Elderberry has been used for centuries to treat upper respiratory infections and support health in the wintertime when we seem more susceptible to these bugs. Here are the major takeaways about Elderberry (a plant in the sambucus family with multiple genuses, including nigra) from study results published in scholarly journals on PubMed. Proven to inhibit the infectious activity of viruses (PMID: 26645032) In a study with influenza A & B symptoms were relieved on average 4 days earlier with Elderberry Syrup (PMID: 15080016) Significant reduction of cold duration and severity (PMID: 27023596) Shown to inhibit the viral replication and block the virus attachment of human coronavirus NL63 (HCoV-NL63) (PMID: 31560964) Water-derived elderberry extracts induce potent immune-modulatory effects, which represents the basis for a strong immune-mediated response to viruses including influenza compared to alcohol extracts that do not do this. (PMID: 35409309) Stimulates immune response and prevents viral infection (PMID: 22972323) Inhibits replication of influenza A, B, swine flu and turkey flu, significant improvement of the symptoms within 2 days, complete cure in 2-3 days in 90% compared to up to 6 days in the placebo (PMID: 9395631) Most of the research focuses on viruses (influenza A, B, swine flu, common cold, and recently coronavirus), but there’s also examples of elderberry protecting against bacterial infections. Active against human pathogenic bacteria (Gram-positive bacteria of Streptococcus pyogenes and group C and G Streptococci, and the Gram-negative bacterium Branhamella catarrhalisas) well as influenza viruses (PMID: 21352539) Ok, so if you want to go down the scientific study of elderberry rabbit hole, click any of the links above and read on to your heart's content. Want to know more about the plant itself and some of its more magical qualities? Stay with me. Black Elder (Sambucus nigra) is a shrub that can easily grow into a tree. It grows in Europe and North America, tolerating many environments and enjoying full sun. Each spring it produces clusters of tiny cream colored flowers called elderflowers. These flowers can connect us to the realm of above and fairies, and they have a strong connection to children, representing purity and innocence. Elderflowers tend to be gentle, yet profound. Then as the heat of summer arrives, the flowers wither and the berries ripen. Depending on the genus of the plant they range in color from a dusty light blue to a deep, dark purple. The berries are typically dried and then extracted in water (sometimes glycerine or alcohol), though as referenced above, water extraction is the superior method. Anthocyanins in the elderberries turn the water a deep purple and these are the compounds that stimulate and support our immune, respiratory systems and more. Elderberries are not sweet on their own. They have an affinity for the root and heart chakras, promoting a sense of being centered and open simultaneously. Which makes sense to me because when I am feeling vibrant and healthy I also feel centered and open, and elderberry helps bring us back to vibrant health. I hope you learned something new reading this. Let me know if you have any questions about Elder.

[idigitizellp21]

Cupping Therapy: All You Need To Know

Cupping therapy, an ancient healing practice that dates back thousands of years which has recently gained admiration as the perfect alternative to traditional medicine. Widely used in various cultures globally, this therapy involves placing cups on the skin to create a suction effect. This non-invasive technique not only promotes healing but also reduces pain, and enhances your overall well-being.

Let’s take a deep dive into some marvellous benefits, methods, and precautionary measures of cupping therapy, providing you with all the essential information you need to know about this intriguing practice.

How Does Cupping Therapy Work?

Cupping therapy involves placing specially designed cups on specific areas of the body. These cups can be made of glass, bamboo, or silicone and they come in various sizes. The therapist uses heat or a pump to create suction inside the cups, drawing the skin and underlying tissue upward into the cup. This suction effect is proven to boost blood flow to the lesser-known body areas and also helps release muscle and ligament tension.

Types of Cupping Therapy Techniques

There are various types of cupping therapies, two mainly being:

1. Dry Cupping: In dry cupping, the cups are placed on the skin after creating suction. They remain in place for a few minutes, and the therapist may move them around to target different areas. This technique leaves characteristic circular marks on the skin, known as “cupping marks.” These marks are not painful and typically fade within a few days. 2. Wet Cupping: Wet cupping, known as “hijama,” or medicinal bleeding, where blood drawn by local suction from a small skin incision involves a two-step method. After dry cupping, the therapist makes small incisions on the skin’s surface before reapplying the cups. This process is believed to draw out toxins and impurities from the body. Wet cupping should only be performed by a cupping therapy expert who are well trained professionals and under sterile conditions. HOWEVER AT SHIFAKHANA WE USE MORE ADVANCE TECHNIQUE USING A DEVICE AND JUST PRICK THE REQUIRED AREA WITHOUT ANY INCISIONS WHICH IS PAINLESS. ALSO THE BLOOD OOZED OUT IS NOT IN EXCESS GIVING YOU ACCURATE RESULTS.

Some Noteworthy Benefits of Cupping Therapy

Cupping therapy is admired for its potential wellness benefits, which include:

1. Pain Relief: Cupping can help alleviate chronic illness conditions such as back pain, neck pain, and migraines by reducing muscle tension and improving blood flow to the affected areas. 2. Relaxation and Stress Reduction: The therapy’s gentle suction and massage-like effect can induce relaxation and reduce stress levels. 3. Improved Circulation: Cupping increases blood flow to the treated areas, which can enhance overall circulation and promote healing. 4. Detoxification: Advocates of wet cupping believe that it aids in the removal of toxins and waste products from the body. 5. Enhanced Immune Function: Some studies suggest that cupping therapy can positively influence the immune system by stimulating white blood cell production.

Cupping Therapy Precautionary Measures

While cupping therapy is an absolutely safe therapy to undertake, there are a few considerations to keep in mind:

1. Could cause Temporary Bruising: Cupping marks are common and usually harmless. However, they might be mistaken for bruising, so it’s essential to understand the difference. 2. If you face a challenge of skin Sensitivity: People with sensitive skin or certain skin conditions should approach cupping with caution to avoid any adverse reactions. 3. May cause Infection: With wet cupping, there is a slight risk of infection if proper hygiene practices are not followed during therapy delivery.

Cupping therapy is an ancient practice that continues to find relevance in today’s world as people seek alternative approaches to health and wellness. While it offers potential benefits for pain relief, relaxation, and improved circulation, it’s essential to consult a qualified healthcare professional before trying cupping therapy, especially if you have any pre-existing health conditions. With adequate care and expert advice and guidance, cupping therapy can be a valuable addition to your overall wellness.

About Shifakhana:

Shifakhana is a wellness centre in Pune, where we abide by the 3 pillars of healing. Seamlessly blending Yoga & Meditation, Cupping therapy and Herbal Medicine, we give you an all-rounded healing exposure.

Our mission is to spread supreme yet all-rounded Naturopathy healing experiences to one and all. Additionally, we desire to open the stringent doors of your conscious mind and ego, unlocking numerous physical knots which hinder your success in achieving good health and a happy mind. If you decide to contact Healers at Shifakhana you are sure to get value for money, customized healing therapies using proven mythologies.

[unopenablebox]

this is an insanely misleadingly overblown press release about a kind of lackluster paper that basically demonstrates none of these claims

the premise of this paper is that there is a version of mouse nodamuravirus (NoV) (which is as best as i can tell not a human pathogen nor terribly similar to any) which, when attenuated via mutation/KO of a protein that suppresses the cells' foreign-RNA-targeting RNAi response, does not cause disease in mice, presumably because the mice can destroy all the viruses with their RNAi pathway instead.

so what this paper shows is if you inoculate mice, even mice lacking the B and T cells that usually confer immune response to vaccines, with attenuated NoV followed by usually-lethal doses of normal NoV, this leads to survival by most of the mice for up to 3 months after initial inoculation. this is interesting because 1. it's unusually long-lasting for an adaptive-immunity-independent immune response 2. it implies that removing RNAi suppression could be a productive method of generating attenuated viruses as part of vaccine production, and that there's some kind of systemic (body-wide) response being generated to this specific attenuated virus (surprising if it really is due to RNAi activity, since RNAi is a cell-autonomous response)

things this paper absolutely does not show:

that this immunity comes from RNAi/is actually processing or responding to the "whole genome" of the virus

that it confers immunity to multiple variants or strains of NoV (they only tested the NoV strain that the attenuated virus was made from)

how strong the induced immune response is (e.g. is it causing the mice other issues from massive inflammation due to circulating attenuated virus or hypothetical circulating small RNAs?)

that it would last beyond 3 months (the press release claims "9 mouse days are 1 human year" which is extremely dishonest w/r/t the timeline of mouse vs. human immune response; for our purposes that's just a lie)

that it would work for a nasal spray (they use a kind of injection not used in human vaccines for everything except a negative control, where they nasal spray in a different virus that isn't immunized against by attenuated NoV and that accordingly it doesn't work on)

that it would work for the flu

that it would work in humans

the first three, especially 1 and 3, are, frankly, crazy oversights from a paper trying to propose a new vaccine development method & type of vaccine response and i'm kind of shocked they weren't addressed in the paper more. 4, 5, 6, and 7 would be pretty unreasonable criticisms of this paper and could be considered out of scope, except that there is an insanely irresponsible press release implying all these things are known.

the only time the paper touches on the idea of creating a non-strain-specific vaccine is in the final paragraph of the discussion a.k.a. the most speculative part. the entire premise of the claim that it would be non-strain-specific depends on the idea that this is all due to the body developing an RNAi-based "memory" of past viruses, possibly due to previous work (from the same lab) claiming that they find extracellular vesicles in the blood containing small viral RNAs after infection with attenuated NoV, and that adding these vesicles to cells promotes NoV resistance. however, they don't demonstrate that these small viral RNA vesicles are either sufficient or necessary to generating the kind of medium/long-term responses they're discussing in this vaccination paper. also, extracellular vesicle research in general is a... messy field with very bad causal demonstration (especially when you need to perfectly isolate the vesicles from any identically-sized viruses among them), it's otherwise not clear how RNAi could lead to a response over the whole body, and they don't even do any other tests impairing RNAi activity in order to confirm more clearly that this is an RNAi-dependent phenomenon.

like, if it were an RNAi-based vaccine that worked by somehow transmitting a long-lasting RNAi response against a virus to most or all cells in the body, that might well be relatively strain-agnostic and much harder for viruses to evade, and there's probably some chance it might work in some immunocompromised people if the b/t-cell-independence of the effect held true in humans and it doesn't work by e.g. also causing massive inflammation. but, uh, it's a real fucking journey from where we are to there.

“Scientists at UC Riverside have demonstrated a new, RNA-based vaccine strategy that is effective against any strain of a virus and can be used safely even by babies or the immunocompromised. Their flu vaccine will also likely be delivered in the form of a spray, as many people have an aversion to needles. “Respiratory infections move through the nose, so a spray might be an easier delivery system,” Hai said. Additionally, the researchers say there is little chance of a virus mutating to avoid this vaccination strategy. “Viruses may mutate in regions not targeted by traditional vaccines. However, we are targeting their whole genome with thousands of small RNAs. They cannot escape this,” Hai said. Ultimately, the researchers believe they can ‘cut and paste’ this strategy to make a one-and-done vaccine for any number of viruses. “There are several well-known human pathogens; dengue, SARS, COVID. They all have similar viral functions,” Ding said. “This should be applicable to these viruses in an easy transfer of knowledge.””

—

Vaccine breakthrough means no more chasing strains

This is HUGE. This will fundamentally change how we get inoculated.

[didanawisgi]

Geert Vanden Bossche: “Many are likely wondering by now whether my theory regarding the further evolution of the virus and the escalation toward a tsunami of C-19 hospitalizations and deaths will ever come to pass and whether such a frightening outcome is indeed the only scientifically plausible scenario for the chronic phase of this pandemic to end. I have asked myself that question hundreds of times. Essentially, people are wondering whether there might be another way to bring this SARS-CoV-2 (SC-2) pandemic to an end. That this pandemic is still very much ongoing is beyond the slightest doubt. The virus continues to systematically produce new variants, even though for quite some time now, these have taken the form of quasispecies[1]. The viral transmission rate is still relatively high, especially because of the high intrinsic infectiousness of the circulating variants and since infections by the currently circulating variants are often mild or asymptomatic.

Even though symptomatic infections now frequently have a milder or more chronic course and viral concentrations in wastewater remain relatively low, it is crystal clear that the currently circulating SC-2 variants still cause C-19 illness, hospitalizations and even deaths. The interpretation by our health authorities and, unfortunately, also by many scientists and experts that this pandemic is gradually fading out to transition into a seasonal infection—like the flu—is, therefore, pure nonsense. It has long been evident that populations in highly C-19 vaccinated regions are unable to develop sterilizing herd immunity. In other words, the SC-2 pandemic is far from over; at most, it has taken on a different course (i.e., a more chronic progression) and has meanwhile caused many animal species to now also serve as reservoirs for the virus.

In my view, the relatively ‘milder’ course of the declining number of acute reinfections can be attributed to a buffering effect exerted by migratory dendritic cells (DCs) patrolling the upper respiratory tract. Their lectin receptors strongly interact with viral sugars on the surface of the highly infectious circulating variants (see Fig. 1 appended below). Upon exposure, an increasing number of these highly infectious variants are ‘parked’ on these DCs instead of being internalized into susceptible epithelial cells. This likely explains the decline in the rate of productive viral infection. This is the main reason why both laypeople and scientists are under the mistaken impression that the pandemic is waning and will soon transition into a seasonal epidemic that—according to our poorly educated health authorities—could be managed in a flu-like manner through annual vaccination of the most vulnerable in the population! However, those among us who made just a bit more effort to understand these complex biological phenomena realize that vaccination against actively circulating respiratory viruses that easily mutate and/or tend to recombine in animal reservoirs not only further promotes viral immune escape but may even be dangerous when the neutralizing capacity of vaccine-induced antibodies (Abs) against new variants to which vaccinated individuals are exposed decreases significantly. This is because such Abs markedly increase the risk of Ab-dependent enhancement (ADE) of infection. Both suboptimal virus neutralization and ADE of infection promote the further spread of the virus, respectively by facilitating natural selection of viral immune escape variants and ‘enhancing’ viral infectiousness.

This begs the question: If vaccination is far from an effective method to curb the spread of currently circulating SC-2 variants that easily mutate or are prone to recombination, what alternative options do we have to contain the ongoing C-19 pandemic, which is now increasingly characterized by viral transmission from individuals with milder but prolonged clinical symptoms?

Given the current immune-epidemiological situation in highly C-19 vaccinated countries, I can only think of two scenarios that could contribute to ending the pandemic -both, however, by promoting the hyperacute tsunami of C-19 hospitalizations and deaths that I have been predicting.

I recently discussed one of these scenarios in a previous contribution that is available on the VSS website (https://www.voiceforscienceandsolidarity.org/scientific-blog/large-scale-flu-vaccination-could-facilitate-or-expedite-a-tsunami-of-case-fatalities). It involves the reverse zoonosis of SC-2 in highly vaccinated C-19 populations, leading to a higher prevalence of mild to asymptomatic infections by avian influenza viruses in birds. The fulminant expansion of highly pathogenic avian influenza virus (HPAI) involving multiple genetic lineages (primarily belonging to the H5N1 subtype) that have evolved through genetic drift and reassortment, is clearly increasing the likelihood that a strain could emerge that is well adapted to humans and capable of enabling human-to-human transmission upon zoonotic spill-over to humans. Airborne avian influenza virus spread by birds could theoretically trigger rapid global panzootics in several mammalian species or even a global pandemic in humans, causing high morbidity and mortality rates, especially in immunologically naïve populations. While this possibility cannot be fully ruled out, I don’t believe HPAI will sufficiently adapt to mammalian populations that have a high prevalence of species-specific anti-influenza antibodies (Abs). Indeed, it is reasonable to assume that the better newly emerging avian flu strains bind to cell-surface receptors of susceptible mammalian cells, the more likely they are to be recognized by pre-existing infection- or vaccine-induced Abs against species-specific seasonal flu viruses. For example, it is estimated that about 50–60% of the human population in the United States has such Abs. However, this recognition is non-functional or suboptimal because these Abs only cross-react with, but do not cross-neutralize, avian flu strains due to some antigenic similarity between certain epitopes on the hemagglutinin (HA) or neuraminidase (NA) proteins. Such cross-reactivity may lead to ADE of disease (ADED) in populations with high levels of anti-flu Abs.

Given the current surge in seasonal influenza cases—especially in C-19 vaccinated individuals—and the recommendations to vaccinate against seasonal influenza, the proportion of the population with high anti-flu Ab titers is now certainly increasing in many highly C-19 vaccinated countries. It is therefore likely that, instead of witnessing a truly global avian flu pandemic, we will see an increasing number of individual case fatalities due to ADED in highly C-19 vaccinated populations. This will not only affect individuals who developed high titers of infection-induced anti-flu Abs after suffering from serious breakthrough infections with seasonal flu, but also those with high vaccine-induced anti-flu Ab titers, regardless of their C-19 vaccination status. For this reason, I strongly advise against vaccination against the seasonal influenza virus, even in the context of current multi-country flu surges. On the other hand, individuals with weak innate immunity (e.g., those with underlying diseases or those who failed to train their cell-mediated innate immunity due to C-19 vaccination) could also develop high anti-flu Ab titers. These individuals might consider taking antiviral medications at the early onset of symptoms.

However, given the current surge in viral respiratory infections unrelated to SC-2 (e.g., seasonal flu, Respiratory Syncytial Virus [RSV], and Human Metapneumovirus [hMPV]) in highly C-19 vaccinated populations, a much more compelling factor is likely to drive the end of the chronic phase of the C-19 pandemic. As previously explained, circulating, highly infectious SC-2 variants are increasingly being adsorbed onto migratory DCs patrolling the upper respiratory tract (URT). This not only dampens the rate of productive viral infection but also prevents antiviral immunity from being stimulated, as DCs cannot serve as antigen-presenting cells (APCs) unless the virus or antigen is internalized into these cells—rather than merely adsorbed onto them. This explains why the evolutionary dynamics of this pandemic seem delayed, as viral production and shedding are diminished but cannot be entirely abrogated due to the lack of sterilizing immunity. At this ‘metastable’ stage of the pandemic, viral transmission largely relies on weak but prolonged viral shedding by an increasing number of repetitively or ‘chronically’ infected individuals.

As this metastable equilibrium[2] creates a sort of steady-state situation, viral inter-host transmission is not yet under sufficient threat to pressure the virus into shifting to a new phenotype capable of overcoming the virus-neutralizing effect of its attachment to URT-patrolling DCs. Such a shift would enable trans infection and trans fusion of susceptible cells in distant organs (see Fig. 1, with reference from the literature provided below).

I have been wondering how this metastable equilibrium could suddenly transition to a more stable, lower-energy state. In other words, the question remains whether the pressure currently exerted on viral infectivity and transmissibility is high enough to trigger such a spectacular immune selection event. Departing from the metastable equilibrium currently evidenced by relatively low SC-2 wastewater levels, along with relatively low C-19 hospitalization and mortality rates, a dramatic ‘Omicron-like’ mutation event would likely be required to reduce the pressure on the viral infection and transmission rate, shifting the system to a more stable state where viral propagation is no longer constrained by hostile host factors.

But what kind of push would provide enough energy for this transition to occur?

It would have to be an event that further hampers viral transmission. Such an event could only arise from the outbreaks of flu or flu-like illnesses, which are currently emerging in several countries. These outbreaks are likely triggered by the shift of acute C-19 illness to chronicity, thereby preventing broadly functional cytotoxic T lymphocytes (CTLs) from mitigating symptomatic SC-2 infection in individuals with poorly trained cell-mediated immunity (CMII). During the acute phase of the pandemic, the overwhelming prevalence of acute SC-2 infections inhibited the training of CMII in C-19 vaccinees, as well as in unvaccinated individuals who suffered severe C-19 disease. Now, however, symptomatic infections caused by other seasonal cold viruses are helping to train their CMII. Consequently, broadly cross-functional CTLs are being activated. These CTLs not only contribute to abrogating viral infection and curb the spread of these other respiratory viruses but also help reduce the transmission of circulating SC-2 variants.

However, instead of enabling herd immunity[3], this additional reduction in the overall SC-2 transmission rate is likely to increase immune pressure on viral transmission beyond the threshold SC-2 can tolerate. Consequently, the current surge in non-SC-2 respiratory infections in highly C-19 vaccinated countries is expected to drive the natural selection of a new coronavirus (CoV) lineage. Such a lineage could prove virulent in individuals who failed to train their CMII, either during the acute phase of the SC-2 immune escape pandemic or during the acute seasonal epidemics currently occurring in the chronic phase of this pandemic.

The emergence of virulence in highly C-19 vaccinated populations would cause a hyperacute C-19 tsunami of hospitalizations and deaths, rapidly eliminating large parts of the population (i.e., those with deficient or insufficiently trained CMII) and enabling the remainder of the population, largely unvaccinated, to end this immune escape pandemic through a combination of sterilizing natural immunity and diminished population density. Indeed, there is a considerable chance that even C-19 vaccinees who still managed to rev up their immune protection following training of their CMII upon exposure to the other, currently circulating respiratory viruses may still not survive. This could particularly be the case in regions where there is currently a high prevalence of seasonal flu infections, which will provide large parts of the C-19 vaccinated population with high titers of anti-flu Abs, even in the absence of vaccination against seasonal flu! As mentioned above, these high titers could make them highly susceptible to ADED when exposed to the rapidly spreading avian influenza strains. The bottom line is that highly C-19 vaccinated countries are on the brink of a major health crisis that could cause healthcare systems to collapse. Fig. 2 below summarizes the virological and immunological changes that occurred at the population level during the C-19 pandemic in highly C-19 vaccinated populations. The graph on the left-hand side illustrates the corresponding changes in the pandemic's evolutionary dynamics.

However, no one knows when the collective pressure on the viral transmission rate will rise to a high enough level to collectively trigger the natural selection of phenotypic variants capable of dramatically reducing the increasing population-level pressure on SC-2, thereby fully unleashing its virulence[4].

As we cannot measure the level of pressure collectively exerted on the viral infection/ transmissibility rate, and since we do not know the level of pressure the virus can tolerate before it transforms into a virulent phenotype, it is impossible to predict when the tsunami of CoV hospitalizations and deaths will occur and how high mortality rates will arise.

No matter how much data is collected on the evolution of mutants, including details about their sequences and prevalence, it will not change the uncertainty of any prediction. The same applies to data collected on the evolution of viral wastewater activity, hospitalization rates, and death rates.

It has taken me quite some time to realize that, regardless of how much surveillance and sequencing data are gathered, any prediction about the timing and amplitude of the tsunami event remains pure speculation. All I can say for certain is that the multitude of current outbreaks of respiratory viral infections in highly C-19 vaccinated countries is now expediting the end of the C-19 pandemic.

A sudden exponential increase in the rate of hyperacute deaths will unambiguously signal the start of a powerful but brief CoV tsunami. None of this, however, will affect the health of unvaccinated individuals who have been regularly exposed during the immune escape pandemic and do not suffer from underlying immunosuppressive conditions.

In other words, the transition from a metastable pandemic state to a stable post-pandemic state will likely occur as a short but spectacular surge in case fatalities, triggered once a CoV lineage capable of escaping DC-mediated inhibition of trans infection is selected. There can be no doubt that the virulence of such a CoV will primarily affect C-19 vaccinees and unvaccinated individuals who previously suffered severe C-19 disease.

The laws of thermodynamics are increasingly making it clear to me that no single model, no single method of surveillance, sequencing, or any other tracking of viral mutants can exactly predict when Nature will proceed with this hyperacute event in order to restore a sound, low-energy equilibrium.

As it has always been my goal to share scientific truth—not only to warn people about the harmful outcomes of human intervention in this pandemic but also to predict when Nature will retaliate—it is now time for me to end my deductive research and communications on this disastrous yet intriguing phenomenon, brought about by the largest gain-of-function experiment ever conducted in the history of mankind, one that, however, involved the human species itself. I have never been interested in the molecular details revealed by either virological or immunological analyses unless they could potentially help me predict the type and timing of the end of this pandemic. I believe I have largely succeeded in sharing substantial parts of the biological truth. However, I eventually have to admit that I will not be able to predict the exact moment when Nature will finally take back control over the health chaos orchestrated by mankind. As I said, no single analysis can shed light on that. This is the complete uncertainty in which we currently find ourselves, despite living in an era of unprecedented technological revolution. We are nothing compared to Nature. From now on, I intend to spend more of the precious time that remains exploring and admiring its beauty, as well as that of the people who respect it. I will continue to participate in the Immune Biology Forum for as long as there is broad and genuine interest of those who want to learn more about the unimaginably disastrous consequences of this insane and unprecedented interference with the immune system of individuals and even with the collective immune protection of entire populations.

Conclusion

Connecting the dots between the overwhelming occurrence of a diverse spectrum of diseases, the ongoing evolution of the virus, the various manifestations of collective immune dysregulation, and the emergence of other viral panzootics (e.g., avian flu) and ongoing outbreaks of viral respiratory infections (e.g., seasonal flu, RSV, hMPV) in highly C-19 vaccinated populations, it becomes difficult to avoid the conclusion that these unprecedented phenomena—particularly their temporal and spatial overlap—are indirectly the result of reckless human intervention in the collective host immune response to the SC-2 pandemic.

In my view, these unprecedented phenomena and their spatial and temporal overlapping in highly C-19 vaccinated countries highlight the detrimental consequences of interfering with natural immunity at both, the individual and population level during a pandemic caused by an acute, self-limiting viral infection. When attempting to connect all these dots, I believe we must acknowledge that only Nature can ultimately bring an end to this pandemic, and its course will not be positively influenced by any of the vaccines that our public health authorities or so-called ‘experts’, who have shown incompetence and ignorance all along, continue advising as the holy grail of public health interventions.

[1] A quasispecies is a well-defined distribution of highly similar but genetically distinct variants that is generated by a mutation-selection process. The composition of a quasispecies is dynamic, with certain variants becoming dominant under selective pressures from environmental changes such as the immune response or antiviral treatments. The diversity within a quasispecies gives the virus a survival advantage by allowing rapid adaptation to such environmental changes.

[2] ‘Metastable’ refers to a state where the equilibrium is only temporarily stable. This can be visualized by the position of a golf ball in a small hole on a steep slope. It is stable under small disturbances (e.g., in the case of weak selection pressure) as those will only make it roll around inside the small hole but then leave it to return to its resting position. However, if perturbed strongly enough (i.e., in the case of strong selection pressure), it can transition to a much lower and stable energy state as a strong push will provide it with enough energy to escape the confines of the hole (i.e., to overcome the energy barrier preventing its transition to a lower energy state) and roll down the steep slope to a much lower position, which represents a more stable equilibrium.

[3] To explain why additional acquisition of CMII training in vaccinees at this late stage cannot longer contribute to herd immunity, I’d like to refer to my answer to a Q raised on the Immune Biology Forum (https://lnkd.in/e9ZRVsFQ):

“You seem to be suggesting that C-19 vaccinees could benefit from exposure (to other currently circulating cold viruses). If so, then wouldn't that create counter pressure to the imminent tsunami? And if an inflection point is reached, herd immunity is then possible?”

Answer: As the pandemic has transitioned into a chronic phase, other "cold" viruses are no longer being largely outcompeted by SARS-CoV-2 (SC-2) variants (see more accurate explanation above in the text). This allows these viruses to cause illness, particularly in poorly trained COVID-19 (C-19) vaccinees and those recovering from severe COVID-19. This situation is especially concerning for vaccinated individuals with underlying immunosuppressive conditions, as they are at higher risk of severe illness and may, therefore, require antiviral treatment.

However, for others, this could present an opportunity for innate immune system training. It is important to note, though, that while this may enhance their immune protection, it will not result in sterilizing immunity. Achieving sterilizing immunity requires the synergistic collaboration of the innate and adaptive immune systems unless cell-mediated innate immunity (CMII) becomes exceptionally robust, capable of eliminating all viral load independently of the adaptive immune system. This level of immune competence has now been observed in unvaccinated individuals who were repeatedly exposed to the virus during this immune escape pandemic. For vaccinated individuals, exposure to one or more of the other circulating respiratory viruses may now enable their CMII to synergize with their adaptive immune system, potentially sterilizing these new infections. However, they won’t be able to strengthen their CMII strongly enough to sterilize the remaining circulating SC-2 variants and generate herd immunity. There are two key reasons for this:

1. Other respiratory infections will be effectively contained, as sterilizing immunity prevents immune escape and recurrent infection.

2. The partial reduction—but not complete sterilization—of SC-2 transmission will rapidly cause the population to exert selective pressure on viral infectivity and transmission.

As SC-2's intrinsic infectiousness is already nearing its upper limit (recent increases have only been marginal), the virus's survival will now likely require the brakes on viral trans infectiousness and intra-host transmission to be lifted. This, in turn, is expected to drive increased virulence and triggering a tsunami of hyperacute fatalities. Tragically, this is likely to happen before all "healthy" C-19 vaccinees got their CMII revved up by circulating flu viruses or other currently circulating respiratory viruses (e.g., RSV, hMPV).

[4] For the purpose of this article, ‘virulence’ refers to the capacity of the virus to trans infect and trans fuse host cells in susceptible individuals. Virulence, therefore, greatly depends on the immune status of the exposed individual.

[rambandrinkstop]

Medication and Treatment Options for Alcohol Addiction | Ramban Drink Stop

Alcohol, often consumed to relax or celebrate, can lead to serious issues like violence, relationship problems, and workplace conflicts. While moderate drinking is often considered acceptable, even a single drink can sometimes lead to lifelong addiction. Alcohol abuse can harm the liver and heart and may also lead to mental health problems like anxiety and depression. Hence, addressing alcohol addiction is crucial. Fortunately, there are various medications and treatments available to help individuals quit alcohol. Let's explore these options.

Modern Medications

Modern medications can help manage alcohol dependency by targeting the psychological aspects of addiction. Drugs like disulfiram, naltrexone, and acamprosate either make alcohol consumption unpleasant or block its euphoric effects. These medications may also help reduce cravings by restoring the brain's chemical balance. They come in pill or injection form, with dosage and frequency determined by a physician.

However, these drugs can have side effects, including headaches, nausea, fatigue, changes in liver function, breathing difficulties, loss of appetite, and anxiety. To improve effectiveness, these medications are often combined with counseling to address withdrawal symptoms and other related issues.

Natural and Herbal Remedies

For those seeking gentler treatment options, natural remedies can be a beneficial complement to conventional methods. Although they may not entirely replace modern treatments, they can support the recovery process.

Here are some helpful herbs:

Ashwagandha: Reduces anxiety and stress, common triggers for alcohol consumption, making it easier to quit.

Kudzu (Pueraria montana): Contains compounds that mitigate alcohol’s effects on the brain, reducing cravings.

Dandelion (Simhadanti): Protects the liver from alcohol-induced damage and can aid recovery when consumed as a concoction.

Brahmi: Enhances mental clarity and emotional balance, crucial for quitting alcohol. It rejuvenates the body and supports alcohol-free living.

Ayurvedic de-addiction remedy- Ramban Drink Stop, an Ayurvedic solution, helps manage addiction and withdrawal symptoms.The following are the benefits of Drink Stop, an ayurvedic cure for alcoholism:

No color or taste, making it easy to consume.

Reduces cravings and prevents relapse.

Offers long-lasting effects.

Detoxifies the liver and prevents further damage.

Benefits of Quitting Alcohol

Quitting alcohol offers numerous benefits, both physical and mental:

Physical Benefits:

Improved heart and liver function, reducing the risk of related diseases.

Enhanced immunity.

Better weight control.

Improved sleep quality.

Mental Benefits:

Reduced anxiety and stress.

Stable mood and improved mental clarity.

Emotional Benefits:

Improved relationships.

Higher self-esteem and confidence.

Financial Benefits:

Better financial status.

Increased productivity and time management.

Lifestyle Changes and Therapy

While medications and herbal remedies are important, lifestyle changes are equally essential. Consider the following:

Avoid places and events where alcohol is served; surround yourself with sober companions.

Therapists can help uncover the root causes of alcohol use.

Maintain a balanced diet and engage in regular physical activity to boost mood and energy.

Practice yoga and meditation to stay mindful of triggers and manage stress.

Connect with individuals who have successfully quit alcohol and lean on family and friends for support.

A Word of Caution

Herbal remedies, though appealing, aren't regulated as strictly as pharmaceutical drugs. Always consult a healthcare provider before starting any new supplement, especially if you're on other medications or have underlying health conditions.

Conclusion

Quitting alcohol is challenging, but with the right combination of medication, herbal remedies, lifestyle changes, counseling, and support, it is achievable. Whether you opt for modern medicine or natural remedies, the ultimate goal is to live an alcohol-free life. Your journey is personal, and the right approach will help you reach that goal.

visit - https://www.rambands.com/ https://www.rambands.com/assets/images/blogs/effective-treatment-for-alcohol-problems.jpg https://www.amazon.in/Saptarishi-Herbals-Ramban-Ayurvedic-Deaddiction/dp/B0DBVKPRZZ

[covid-safer-hotties]

Reference archived on our website

I know some people will celebrate, but the West has been dragging behind in covid vaccine development, and the issue with these vaccines is they only help provide herd immunity if people actually get them. Two struggles to overcome before we can party.

BACKGROUND. The level of nasal spike-specific secretory IgA (sIgA) is inversely correlated with the risk of SARS-CoV-2 Omicron infection. This study aimed to evaluate the safety and immunogenicity of intranasal vaccination using Ad5-S-Omicron (NB2155), a replication-incompetent human type 5 adenovirus carrying Omicron BA.1 spike.

METHODS. An open-label, single-center, investigator-initiated trial was carried out on 128 health care workers who had never been infected with SARS-CoV-2 and had previously received 2 or 3 injections of inactivated whole-virus vaccines, with the last dose given 3–19 months previously (median 387 days, IQR 333–404 days). Participants received 2 intranasal sprays of NB2155 at 28-day intervals between November 30 and December 30, 2022. Safety was evaluated by solicited adverse events and laboratory tests. The elevation of nasal mucosal spike-specific sIgA and serum neutralizing activities were assessed. All participants were monitored for infection by antigen tests, disease symptoms, and the elevation of nucleocapsid-specific sIgA in the nasal passage.

RESULTS. The vaccine-related solicited adverse events were mild. Nasal spike-specific sIgA against 10 strains had a mean geometric mean fold increase of 4.5 after the first dose, but it increased much higher to 51.5 after the second dose. Serum neutralizing titers also increased modestly to 128.1 (95% CI 74.4–220.4) against authentic BA.1 and 76.9 (95% CI 45.4–130.2) against BA.5 at 14 days after the second dose. Due to the lifting of the zero-COVID policy in China on December 7, 2022, 57.3% of participants were infected with BA.5 between days 15 and 28 after the first dose, whereas no participants reported having any symptomatic infections between day 3 and day 90 after the second dose. The elevation of nasal nucleocapsid-specific sIgA on days 0, 14, 42, and 118 after the first dose was assessed to verify that these 2-dose participants had no asymptomatic infections.

CONCLUSION. A 2-dose intranasal vaccination regimen using NB2155 was safe, was well tolerated, and could dramatically induce broad-spectrum spike-specific sIgA in the nasal passage. Preliminary data suggested that the intranasal vaccination may establish an effective mucosal immune barrier against infection and warranted further clinical studies.

[spaindia]

Relax and Unwind with Stress-Busting Spa Therapies

These massages are excellent ways to show your body some love and care.

Even if it's inevitable, stress is detrimental for your mental and physical health. Physical and mental exhaustion are common outcomes of doing things like attending to social engagements, managing professional tasks, and navigating city traffic. Your health may take a serious hit if you're already struggling to meet the demands of your job and personal responsibilities while also dealing with the stress of commuting. 

You haven't been giving yourself the attention you need. Sure, eating well and getting enough exercise are essential components of a healthy lifestyle, but so is treating yourself to a little R&R every once in a while to help you unwind and recharge. After all, a crowded mind makes it impossible to feel happy. Scientific research suggests that a massage can induce a "feel good" state in your body and mind, similar to the "feel good" condition you experience after a successful exercise, as it releases the hormone serotonin. 

A trip to the best spa in Delhi may be a wonderful stress reliever. Spas offer numerous health advantages in addition to cosmetic and relaxation therapies. 

How Do Spa Treatments Help?

Indulge in a spa treatment, which may revitalize your body and soul in no time.  Instant relaxation during and after treatment is a major effect. Relaxation and relief from stress are the results of a combination of a relaxing atmosphere and skilled massage methods. 

Beauty treatments, such as facials and body scrubs, may also improve the look of your skin, giving you a more awake appearance. Feeling reenergized and rejuvenated is just one of the many benefits of reducing stress hormones and increasing endorphins. 

Let's have a look at various stress-busting spa therapies:

A massage using aromatherapy

Aromatherapy is the best spa wellness in India that many people love. Relaxation on all levels is the goal of this massage, which makes use of the calming effects of pure essential oils. Instead of using physical pressure, the therapist uses light, rhythmic strokes that draw on the therapeutic qualities of the essential oils to alleviate tension, encourage restful sleep, improve circulation, and flush out toxins. 

A specially formulated combination of essential oils is used to address certain parts of the body that are causing discomfort, since each oil has its own distinct function. The oils often treat conditions like congestion and muscular spasms due to their therapeutic effects. 

A massage in Bali 

In order to promote the body's natural circulation of blood, oxygen, and 'chi' (energy), a Balinese massage practitioner uses a combination of acupressure, light stretching strokes, palm pressure, and high-pressure deep tissue techniques. An increase in blood flow helps alleviate tension and restores homeostasis. 

The Swedish massage

Swedish massage, a medium-pressure technique, promotes circulation and an overall sense of well-being to help one feel calm and pleased. This traditional massage method for releasing knotted muscles and other trouble spots makes use of a wide range of strokes, glides, kneads, rubs, tapping, and hammering, among others. By manipulating muscles over bone structure, the massage boosts immunity and lasts anywhere from sixty to ninety minutes. 

Lomi-Lomi treatment 

One of the best ways to relax is with a Lomi-Lomi treatment, which is like a Hawaiian massage. Its signature lengthy, continuous strokes of deep tissue massage aid in the release of limiting beliefs and habits. During the session, moisturisers such as macadamia, palm, or coconut oils are often used on the skin to nourish it and keep the strokes smooth. 

Acupuncture

Reflexology or zone treatment involves applying pressure to specific areas of the body, such as the feet, hands, or ears. This method reduces stress in the body by sending a signal to the central nervous system from the periphery, which then instructs the body to relax. Relaxation is only one of the many benefits of this treatment; it also aids in the reduction of tension and discomfort. 

Hair Spa sessions

The most effective way to relax is to get a hair spa treatment. Daily exposure to astounding quantities of dust and pollutants can harm your hair. Hair spas are wonderful for more than just relaxing; they also feed the hair, which helps it to stay soft and healthy for longer. 

Visit Spa Hibiscus for a Relaxing Experience

A beneficial method to improve your health and deal with stress is to make regular spa visits a part of your routine. The advantages are obvious whether you visit our Spa Hibiscus facility or try to replicate a spa atmosphere at home.

Frequent spa sessions and prioritizing self-care can help you find balance in your life and foster inner calm. Experience the revitalizing effects of the best spa wellness in India and find a way to achieve improved relaxation and well-being by treating yourself to these therapies.

Indulge in some self-care today, you deserve it!

[jlareditor1]

Diabetes Mellitus (DM) is a multitudinous metabolic disorder that can occur due to insufficient or inefficient levels of insulin that leads to hyperglycemia. In many conditions, diabetes can also directly or indirectly lead to other functional disorders such as dyslipidemia and hypertension making them more severe and life-threatening. It is believed that Type 1 Diabetes can be caused by to process of auto-immune destruction of beta-cells of Islet of Langerhans of the pancreas responsible for the production of insulin whereas Type 2 diabetes is because of resistance against insulin along with the futilities of beta-cells to compensate the body with the required amount of insulin. The animal models are considered an essential component in the experimental studies and drug discovery process. Animal models provide safety, effectiveness, and dose of the test substance that needs to be extrapolated to human use. There are several methods for the induction of diabetes in experimental animal models. The present review aimed to discuss and explore currently used approaches including models from streptozotocin-induced diabetes to transgenic models for reproducible and safe diabetes induction in different experimental animals (rats, mice, guinea pigs, and dogs) and sex. Additionally, some genetically modified animal models are also included and discussed in this review which will pave the way for further studies.

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[jadhav1999]

Modern Homeopathy’s Science-Backed Remedies for Heart Disease: Real Success Stories

Heart disease remains one of the leading causes of morbidity and mortality worldwide. While conventional treatments for heart disease often involve complex surgical interventions and long-term medications, many patients are seeking alternative, holistic approaches that offer safer, effective, and side-effect-free options. Modern homeopathy is one such approach, with a steadily growing reputation for successfully addressing chronic and severe heart conditions. Here, we delve into the science-backed remedies offered by modern homeopathy, exploring how it leverages both traditional principles and scientific advancements to provide personalized, non-invasive treatments. We’ll also share real-life success stories that highlight its positive impact on heart disease patients and underscore the value of this promising approach.

What Is Modern Homeopathy?

Modern homeopathy builds on traditional homeopathy’s principles but takes a more scientifically driven approach. Rooted in the idea that “like cures like,” homeopathy posits that substances capable of inducing certain symptoms in healthy individuals can, in highly diluted forms, treat similar symptoms in sick individuals. Modern homeopathy adapts this framework by incorporating research-backed methods and a personalized approach, taking into account each individual’s symptoms, health history, lifestyle, and even psychological factors. The goal is to offer a treatment tailored specifically to the patient’s unique physiological makeup.

Why Choose Modern Homeopathy for Heart Disease?

Heart disease develops over time and can manifest in various forms, including coronary artery disease, heart failure, cardiomyopathy, and congenital heart defects. Factors such as high blood pressure, diabetes, lifestyle habits (e.g., smoking and diet), and family history contribute to its onset. Traditional treatments often require invasive procedures, long-term drug dependence, and lifestyle restrictions, which may not suit everyone. Here’s why modern homeopathy is becoming a preferred alternative:

Non-Invasive Treatment: Homeopathic remedies stimulate the body’s innate healing mechanisms, supporting heart health without the need for surgical interventions.

Personalized Care: Treatment is customized to align with the individual’s symptoms, medical history, lifestyle, and emotional factors, allowing for a highly targeted approach.

Safe and Side-Effect-Free: Homeopathic remedies are derived from natural substances and are highly diluted, minimizing the risk of side effects and making them suitable for people of all ages.

Comprehensive Healing: Rather than merely addressing symptoms, modern homeopathy considers the whole person, promoting overall wellness that extends beyond heart health.

Understanding the Causes and Development of Heart Disease

Heart disease often develops insidiously, influenced by a combination of genetic, environmental, and lifestyle factors. High blood pressure, high cholesterol, obesity, smoking, excessive alcohol consumption, poor diet, and sedentary lifestyle increase the risk of cardiovascular conditions. Modern homeopathy seeks to address these contributing factors by not only treating symptoms but also targeting underlying imbalances and weaknesses, helping to restore natural homeostasis and resilience within the body.

The Role of Modern Homeopathy in Treating Heart Disease

Homeopathic treatment for heart disease focuses on fortifying the heart’s function, improving circulation, and strengthening the body’s overall immune response. Modern homeopathy also targets specific symptoms associated with different types of heart disease, such as:

Improving Blood Flow: Remedies can be selected to assist in improving blood flow, reducing plaque buildup in arteries, and enhancing overall circulation.

Reducing Inflammation: Some homeopathic solutions are geared towards reducing inflammation, a common underlying factor in many heart conditions.

Enhancing Heart Strength: By strengthening the heart muscle, homeopathic remedies help it pump blood more efficiently, which is essential in conditions like cardiomyopathy or heart failure.

Supporting Immune Health: Many heart conditions are worsened by a weakened immune system, and homeopathy aims to strengthen immunity, thereby preventing recurrent illnesses that could strain the heart.

Success Stories: Real Cases of Heart Healing through Modern Homeopathy

Master Atharv’s Journey to a Healthier Heart

Master Atharv’s story exemplifies the potential of modern homeopathy for children with severe heart conditions. Diagnosed with rheumatic heart disease in Germany, Atharv suffered from limb pain, an enlarged heart, and weak immunity, which conventional treatments, including steroids, failed to alleviate. Following valve replacement surgery, his heart condition relapsed, leaving his parents worried and disheartened.

Upon returning to India, they sought the help of Dr. Vijaykumar Mane, a specialist in modern homeopathy. Within the first month of starting Atharv’s homeopathic treatment, his health began to improve significantly. His recurrent fevers and illnesses subsided, his immune system strengthened, and his physical growth normalized. Atharv resumed school, and his heart condition stabilized without further complications. His mother now champions the transformative effects of modern homeopathy for heart disease, expressing her gratitude for the holistic recovery her son achieved.

Soham Acholkar’s Remarkable Recovery from Congenital Heart Disease

Soham Acholkar’s journey is another powerful testament to modern homeopathy’s efficacy. Born with severe cyanotic congenital heart disease—including conditions like Transposition of the Great Arteries (TGA), Ventricular Septal Defect (VSD), Patent Ductus Arteriosus (PDA), and Atrial Septal Defect (ASD)—Soham’s life was riddled with challenges. After undergoing surgery at four months old, he faced continued health setbacks, including breathlessness, frequent ICU admissions, and limitations on normal childhood activities.

When his parents met Dr. Mane, they were desperate for a treatment that could stabilize Soham’s heart health without invasive procedures. Modern homeopathic treatments were introduced, and within a month, Soham experienced relief from his symptoms. His breathlessness improved, and he gradually began to participate in physical activities, attend school, and live a more typical life. Today, Soham leads a healthy, active life, with no signs of his earlier cardiac symptoms, thanks to the personalized care and comprehensive approach of modern homeopathy.

Scientific Basis of Modern Homeopathy in Heart Disease Treatment

The effectiveness of modern homeopathy in treating heart disease has its basis in the principle of “like cures like” and is further bolstered by scientific advances in biochemistry and immunology. Here’s how modern homeopathy supports heart health:

Micro-Dosing for Precision: Homeopathic remedies are prepared through a process of dilution and succession (vigorous shaking), which enhances the healing properties of natural substances at a molecular level. This results in “micro-dosing” that stimulates the body’s healing response without overwhelming it.

Targeted Immune Support: Modern homeopathy includes immune-boosting remedies that improve resilience against infections and stressors that can exacerbate heart disease.

Systematic Detoxification: Some homeopathic treatments support the detoxification of heavy metals and other toxins, helping to reduce strain on the cardiovascular system.

Anti-Inflammatory Benefits: Remedies such as Arnica Montana, Crataegus Oxyacantha (Hawthorn), and Aurum Metallicum are known for their anti-inflammatory properties, which are especially beneficial for reducing inflammation in the arteries.

Psychosomatic Healing: Homeopathy addresses the interconnectedness of the mind and body, often reducing anxiety and stress—factors that can aggravate heart disease.

Challenges and the Future of Modern Homeopathy in Cardiology

Despite these success stories and the growing acceptance of modern homeopathy, challenges remain. Skepticism about the effectiveness of homeopathy, particularly among conventional medical practitioners, persists due to a lack of large-scale clinical trials. However, there is a shift as more scientific studies highlight the potential mechanisms behind homeopathy’s efficacy. Continued research, alongside documented patient successes, will be crucial in bridging the gap between homeopathy and mainstream medicine.

Conclusion: A Promising Future for Heart Disease Patients

Modern homeopathy offers a promising alternative for individuals seeking a holistic, non-invasive approach to heart disease. As seen in the journeys of Atharv and Soham, the potential for healing through personalized, science-backed remedies is profound. Modern homeopathy addresses not just the physical symptoms but the whole person, supporting heart health in a way that is safe, effective, and sustainable.

The field of modern homeopathy is continually evolving, with research and patient outcomes demonstrating that it can play a valuable role in managing heart disease. For those looking for an alternative or complementary therapy, modern homeopathy stands as a beacon of hope, providing a comprehensive path to heart health, resilience, and overall well-being.

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Home Remedies for Combating Seasonal Allergies

The symptoms of seasonal allergies, which are frequently brought on by pollen, mold, and other environmental factors, can cause problems with day-to-day activities and include sneezing, itchy eyes, and congestion.

These allergies, which can cause painful and even fatal symptoms, are caused by our immune system's reaction to allergens in the air during particular seasons.

Home remedies provide a natural, side-effect-free method of effectively managing allergy symptoms, while over-the-counter medicines provide relief.

Home Remedies for Combating Seasonal Allergies

Symptoms of Seasonal Allergies

You can differentiate seasonal allergies from other medical disorders by being able to recognize their symptoms.

Sneezing, a runny or clogged nose, watery or itchy eyes, a sore throat, and fatigue are typical symptoms.

These symptoms are made worse by higher concentrations of pollen and other allergens in the air during the spring and fall seasons of the year.

Finding relief begins with addressing these symptoms.

Benefits of Using Home Remedies for Allergy Relief

Without the negative effects of generic medications, home remedies provide a gentle yet efficient means of relieving allergy symptoms.

Natural remedies often lack the same side effects as allergy medications, such as dry mouth or drowsiness.

To offer an extra degree of alleviation, they can also be used in conjunction with conventional therapies.

You might find it simpler to consistently and sustainably control your symptoms if you choose natural solutions.

Saline Nasal Rinse - A Simple Way to Clear Nasal Passages

A tried-and-true method for clearing allergies from your nasal passages is to use a saline nasal rinse.

Pollen and other material can be removed by rinsing with a saline solution, which can ease congestion while helping breathing.

Rinsing the sinuses with a neti pot or saline spray can help to reduce mucus accumulation and inflammation.

A readily available treatment is saline nasal rinses, which can be performed at home using a basic solution of salt and water or a premade solution.

Honey - Nature’s Sweet Solution

The body is believed to develop a resistance to local pollen by consuming local honey.

According to one idea, continuous exposure to trace amounts of local pollen found in honey may gradually desensitize your immune system, hence lowering allergy symptoms.

During allergy season, consuming a tablespoon of local, raw honey daily may help reduce symptoms.

To take advantage of honey's natural, sweet advantages, try adding it to your tea or smoothies, or just eat a tablespoon every day.

Herbal Teas - Soothing Relief with Anti-Inflammatory Properties

Some herbal teas, such as chamomile, peppermint, and ginger, can offer calming relief from allergic symptoms.

These teas can lessen inflammation in the throat and nasal passages because they have anti-inflammatory and antihistamine qualities.

Breathing difficulties and congestion can also be improved by drinking warm herbal tea.

Try chamomile for its relaxing and anti-allergic qualities, peppermint for its congestion advantages, and ginger tea for its anti-inflammatory effects.

Read: Secret Headache Relief Tricks Nobody Talks About 

Apple Cider Vinegar - An Antihistamine Boost

As a natural antihistamine, apple cider vinegar is a well-liked home treatment that may help lessen allergy symptoms.

This vinegar is believed to promote lymphatic drainage and aid in the breakdown of mucus, which can reduce congestion and help with breathing.

Try drinking a glass of water with one tablespoon of apple cider vinegar once or twice a day to see if it helps with your symptoms.

Honey can be added for taste and additional health benefits.

Essential Oils for Allergy Relief

Essential oils that induce relaxation and reduce allergy symptoms include lavender and eucalyptus.

While lavender oil contains relaxing and anti-inflammatory properties that may lessen discomfort, eucalyptus oil functions as a natural decongestant.

For aromatherapy advantages, try adding a few drops to a warm bath or using them in a diffuser.

Breathing becomes easier when eucalyptus steam is inhaled to relieve congestion.

When utilized properly, essential oils can be a very effective tool for treating allergies.

Probiotics - Strengthening the Immune System

Your immune response may be strengthened by a healthy gut, which may lessen the intensity of allergy symptoms.

The immune system and the body's reaction to allergens may be balanced by probiotics, or "good" bacteria.

The immune system can be strengthened by eating foods high in probiotics, such as yogurt, kefir, sauerkraut, and others.

During allergy season, if you dislike eating foods high in probiotics, think about taking a good probiotic supplement.

Include Vitamin C and Quercetin in Your Diet

Strong antioxidants like quercetin and vitamin C can naturally lessen allergy symptoms by lowering histamine production.

Citrus fruits, berries, and leafy greens are good sources of vitamin C, which functions as a natural antihistamine to reduce runny nose, itching, and sneezing.

Apples, onions, and green tea contain quercetin, which stabilizes histamine-releasing cells.

By including these items in your diet, you can strengthen your immune system and lessen the impact of allergy symptoms.

Lifestyle Tips to Prevent Seasonal Allergy Triggers

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What Are the Latest Advances in Regenerative Medicine?

In recent years, the field of regenerative medicine has witnessed remarkable advances, driven by innovations in science and technology. This multidisciplinary area focuses on repairing, replacing, or regenerating damaged tissues and organs, offering the promise of more effective treatments for a variety of medical conditions. As our understanding of cellular biology and the mechanisms of healing deepens, the potential for regenerative medicine to transform healthcare grows ever more tangible. This article explores some of the latest breakthroughs in regenerative medicine, highlighting their implications for future therapies and patient outcomes.

Stem Cell Therapies: Pioneering Tissue Repair

One of the most significant advancements in regenerative medicine is the use of stem cell therapies. Stem cells have the unique ability to differentiate into various cell types, making them invaluable for tissue repair and regeneration. Recent research has focused on harnessing the potential of both embryonic and adult stem cells to treat a range of conditions, including neurodegenerative diseases, cardiovascular disorders, and musculoskeletal injuries.

One of the key developments in this field is the application of induced pluripotent stem cells (iPSCs). Scientists have discovered methods to reprogram adult cells into a pluripotent state, allowing them to develop into any cell type. This has opened new avenues for personalized medicine, as iPSCs can be derived from a patient’s own cells, reducing the risk of immune rejection and ethical concerns associated with embryonic stem cells. In clinical trials, iPSC-derived therapies have shown promise in treating conditions such as spinal cord injuries and retinal degenerative diseases, paving the way for future applications across various medical fields.

Tissue Engineering: Building Replacement Tissues

Another exciting area within regenerative medicine is tissue engineering, which involves the creation of artificial organs and tissues using a combination of cells, biomaterials, and growth factors. Recent advances in 3D bioprinting technology have revolutionized this field, enabling researchers to construct complex tissue structures with precision. By layering living cells and biomaterials, scientists can create functional tissues that mimic the natural architecture of human organs.

For instance, researchers have made significant strides in engineering skin, cartilage, and even vascular tissues. These engineered tissues can be used for transplantation, reducing the reliance on donor organs and addressing the shortage of available grafts. Additionally, tissue-engineered constructs can be utilized in drug testing and disease modeling, providing valuable insights into various conditions without the ethical concerns associated with animal testing.

Gene Therapy: Revolutionizing Treatment Approaches

Gene therapy represents another frontier in regenerative medicine, offering the potential to treat genetic disorders at their source. Advances in gene editing technologies, such as CRISPR-Cas9, have made it possible to precisely modify genes within living organisms. This revolutionary approach enables the correction of genetic mutations that cause diseases, opening new pathways for treatment.

Recent clinical trials have demonstrated the efficacy of gene therapies in treating conditions like hemophilia, muscular dystrophy, and certain forms of inherited blindness. By delivering corrected copies of genes or using gene editing techniques to repair faulty genes, researchers have made significant progress in restoring normal function in affected tissues. As the safety and efficacy of these therapies are further established, gene therapy may become a standard treatment option for a range of genetic disorders.

Exosome Therapy: Harnessing Cellular Communication

A relatively new area of research within regenerative medicine is the use of exosomes, which are small vesicles secreted by cells that play a crucial role in intercellular communication. Exosomes contain proteins, lipids, and nucleic acids that reflect the state of their parent cells, making them valuable for therapeutic applications. Recent studies have shown that exosomes derived from stem cells can promote tissue repair and regeneration by modulating inflammation, enhancing cell survival, and stimulating tissue regeneration.

The advantages of exosome therapy lie in their ability to facilitate communication between cells and promote healing without the need for direct cell transplantation. This approach has shown promise in treating conditions such as cardiovascular diseases, neurodegenerative disorders, and injuries. As research continues to uncover the mechanisms underlying exosome function, their potential as a therapeutic tool in regenerative medicine becomes increasingly evident.

Personalized Medicine: Tailoring Treatments for Individual Patients

The concept of personalized medicine is gaining traction within regenerative medicine, as advances in genomics and biotechnology allow for tailored therapeutic approaches. By analyzing an individual’s genetic makeup, researchers can identify specific biomarkers that predict treatment responses, enabling the development of targeted therapies.

In regenerative medicine, personalized approaches can optimize stem cell therapies, tissue engineering, and gene therapies. For example, by understanding a patient’s unique genetic profile and disease mechanisms, clinicians can select the most appropriate stem cell source or engineering strategy for tissue repair. This shift towards personalized medicine not only enhances treatment efficacy but also minimizes the risk of adverse effects, ultimately improving patient outcomes.

Conclusion

The latest advances in regenerative medicine hold the promise of transforming healthcare by providing innovative solutions for tissue repair and regeneration. From stem cell therapies and tissue engineering to gene therapy and exosome therapy, these breakthroughs are paving the way for more effective treatments for a wide range of medical conditions. As research continues to evolve, the potential for personalized medicine to tailor regenerative therapies to individual patients will further enhance the effectiveness of these approaches.

Brands like Edge Peptide Therapy are at the forefront of this exciting field, offering access to cutting-edge therapies that harness the power of peptides and other regenerative technologies. By integrating the latest scientific advancements into therapeutic practices, they are committed to improving health outcomes and enriching the lives of individuals seeking recovery and rejuvenation. As regenerative medicine continues to advance, the future of healing appears brighter than ever, with the potential to change the landscape of medical treatment for years to come.