#selegiline

[seagullcharmer]

besties for the resties

[knifedog]

Sally got prescribed selegiline which should help with the sundowning. it's a liquid i have to squirt into her mouth every morning and it'll be a week before we see a change.

its something she'll have to be on for the rest of her life but if it helps her it's worth the hassle. i just want her to be comfortable.

oh and she also got her rabies vaccine so she can go fight raccoons

[kingsofeverything]

Hi Lauren I just read your post on Rufus and I just wanted to let you know that I'm going through the same thing with my baby boy. I have a Morkie named Lucky he is 13yrs old and my poor baby was recently diagnosed with Dementia and Glaucoma/Cataracts. He has also been dealing with Diabetes for a few years now. My Lucky is blind and can't hear as well as he used to so getting around has been rough. He sleeps a lot throughout the day but he does still sleep at night however more frequently he gets up to either walk around or just stare at the wall. I'm just trying to make him as comfortable as I can. This is all new to me as well and sometimes I wonder if he doesn't go naturally to heaven will I be able to make that final decision. I honestly don't know but I pray for guidance and strength. I'm praying for you as well.. I hope you have a great night.

i'm sorry to hear about lucky! sending you guys love.

it's been rough around here. rufus is taking a lot of meds for his anxiety and sleep and it's helping for now. we've already had to add/adjust because what worked at first stopped working after a few weeks. my vet's main concern (and mine) is that rufus is happy and comfortable. i know we'll wind up having him put to sleep just because from what i've learned about ccd is that once their minds reach a certain point, they're afraid all the time. right now rufus takes selegiline in the morning, then around 3pm i give him 300mg of gabapentin. at 8:30ish he gets another 300mg of gabapentin and 10mg melatonin. that's what's working for now.

he's still eating and drinking and he's remembering to go outside to go to the bathroom, so i'm thankful. once he stops doing any of those, we'll have to reevaluate. but it's end of life care at this point.

[zayashr]

ما هو علاج مرض باركنسون؟

علاج مرض باركنسون يشمل مجموعة من الاستراتيجيات تهدف إلى تخفيف الأعراض وتحسين جودة الحياة. لا يوجد علاج نهائي للمرض، ولكن هناك عدة خيارات علاجية يمكن أن تساعد في إدارة

جراحات مرض باركنسون تُستخدم عادةً لعلاج الأعراض عندما لا تكون الأدوية كافية أو عندما تسبب الأدوية آثارًا جانبية غير مقبولة. هناك عدة أنواع من الجراحات التي يمكن استخدامها لعلاج مرض باركنسون:

الأعراض بشكل فعال.

1. الأدوية:

ليفودوبا/كاربيدوبا (Levodopa/Carbidopa): يعتبر العلاج الأكثر فعالية. ليفودوبا يتحول إلى دوبامين في الدماغ، مما يساعد على تخفيف الأعراض الحركية. كاربيدوبا يساعد على منع تحلل ليفودوبا قبل وصوله إلى الدماغ.

ناهضات الدوبامين (Dopamine Agonists): مثل براميبكسول (Pramipexole) وروبينيرول (Ropinirole)، تحاكي عمل الدوبامين في الدماغ.

مثبطات مونوامين أوكسيداز ب (MAO-B Inhibitors): مثل سيليجيلين (Selegiline) ورازاجيلين (Rasagiline)، تساعد على الحفاظ على مستوى الدوبامين في الدماغ.

مثبطات ناقلة الكاتيكول-أو-مثيل ترانسفيراز (COMT Inhibitors): مثل إنتاكابون (Entacapone)، تساعد على زيادة فعالية ليفودوبا.

الأدوية المضادة للكولين (Anticholinergics): تستخدم لتقليل الرعاش وتحسين التوازن.

أمانتادين (Amantadine): يمكن أن يساعد في التحكم في الحركات غير الطوعية (dyskinesia) الناتجة عن استخدام ليفودوبا.

2. الجراحة:

التحفيز العميق للدماغ (Deep Brain Stimulation - DBS): يتضمن زرع أقطاب كهربائية في مناطق محددة من الدماغ. جهاز مولد النبضات الكهربائية المزروع تحت جلد الصدر يرسل إشارات كهربائية لتنظيم نشاط الدماغ.

الاستئصال الجراحي (Lesioning): يشمل تدمير مناطق معينة من الدماغ مثل الكرة الشاحبة أو المهاد لتخفيف الأعراض.

3. العلاج الطبيعي والتأهيل:

العلاج الطبيعي: يساعد على تحسين القوة، التوازن، والمرونة.

العلاج الوظيفي: يساعد المرضى على تحسين قدراتهم في أداء الأنشطة اليومية.

العلاج بالكلام: يساعد في تحسين مشاكل النطق والبلع.

4. الدعم النفسي والاجتماعي:

العلاج النفسي: يمكن أن يساعد في التعامل مع الاكتئاب، القلق، والتغيرات المزاجية المرتبطة بالمرض.

مجموعات الدعم: توفر الدعم العاطفي والاجتماعي للمرضى وعائلاتهم.

5. العلاجات التكميلية:

التغذية السليمة: النظام الغذائي المتوازن يمكن أن يساعد في الحفاظ على الصحة العامة.

العلاج بالموسيقى، العلاج بالفن، والعلاج بالحيوانات: يمكن أن تساعد في تحسين الحالة النفسية وتقليل التوتر.

6. الإدارة الذاتية:

التمارين الرياضية: ممارسة التمارين بانتظام يمكن أن تساعد في تحسين الحركة واللياقة البدنية.

التثقيف المستمر: معرفة المزيد عن المرض وكيفية التعامل معه يمكن أن يساعد المرضى وأسرهم في إدارة الحالة بشكل أفضل.

العوامل المؤثرة في اختيار العلاج:

مرحلة المرض: تختلف العلاجات باختلاف مراحل المرض.

الأعراض السائدة: يحدد نوع الأعراض وشدتها الخيارات العلاجية الأنسب.

الحالة الصحية العامة: يؤثر وجود حالات طبية أخرى على اختيار العلاج.

المتابعة والرعاية:

الزيارات المنتظمة للطبيب: لتقييم تقدم العلاج وتعديل الخطة العلاجية إذا لزم الأمر.

الفحوصات الدورية: للتحقق من الآثار الجانبية ومراقبة الصحة العامة.

تحتاج إدارة مرض باركنسون إلى نهج متعدد التخصصات يشمل الأطباء والمختصين في العلاج الطبيعي والوظيفي والنفسي لتقديم الرعاية الشاملة والدعم المستمر للمرضى.

[teachingrounds]

Q. There are 5 second-line medications for migraine prophylaxis. What are they?

.

.

.

A. Monoamine oxidase inhibitors (e.g. selegiline / Emsam*), botulinum toxin A (Botox), calcitonin gene-related peptide (CGRP) inhibitors, cyproheptadine (Periactin), and gabapentin (Neurontin).

Pro-Tip: Of these, cyproheptadine and gabapentin have unproven efficacy.

Source for this week is Jasvinder Chawla’s “Migraine Headache Treatment & Management” article on Medscape.

Picture of selegiline / Emsam

[johnmark0404]

Adderall and Methylphenidate Difference and Potency: Choose Your Option for ADHD

Adderall and Methylphenidate medicines are used to treat attention deficit Hyperactivity disorder Composition: Adderall formulation of amphetamine salts, including dextroamphetamine and levoamphetamine. Belongs to the group of phenethylamine class Methylphenidate is a phenethylamine derivative. and belongs to the piperidine class. Side effects: Adderall can increase heart rate and blood pressure not suitable for people with heart deseaseProlonged use can lead to dependence. Methylphenidate: it can cause loss of appetite, sleep difficulty, dry mouth, nausea, stomach ache, and dizziness can also cause anxiety, and irritability Both are available in immediate and extended-release formulations. Prescribed extended-release versions of Adderall are Adderall XR and Mydayis

While Methylphenidate, popular extended-release forms Concerta and Ritalin LA Adderal works negatively with MAO inhibitors.

Avoid using MAO inhibitors like isocarboxazid, linezolid, metaxalone, methylene blue, safinamide, selegiline, and tranylcypromine when using Adderall. While with Methylphenidate stop taking MAO like moclobemide, phenelzine, procarbazine, and rasagiline. Dexmethylphenidate and methylphenidate and drugs which have dexmethylphenidate. 

[biomedres]

Ligand-Based Virtual Screening for the Inhibitors of Monoamine Oxidase B

Ligand-Based Virtual Screening for the Inhibitors of Monoamine Oxidase B in Biomedical Journal of Scientific & Technical Research

https://biomedres.us/fulltexts/BJSTR.MS.ID.006029.php

The inhibition of monoamine oxidase enzyme suggests the significant target for the regulation of depression and Parkinson’s disease. The current studies were based on the identification of potent scaffold from several known inhibitors of monoamine oxidase and marketed inhibitors of MAO-B namely selegiline, rasagiline and safinamide were retrieved from Zinc database and database was prepared. Based upon the pharmacophore, screening of potential inhibitors of MAO-B downloaded from databases were done. Different similarity searching on the basis of structures of rasagiline and safinamide assembled a total of 456 compounds from Zinc database. Out of these 456, 37 compounds were chosen, and filter was applied for the generation of pharmacophore method. The resultant binding interactions and binding energies inside the active pocket were monitored and reported. The lowest binding energy and highest binding interactions were established for ZINC ID 89775104 as -12.43. ADME properties of all the 37 compounds were also performed. These findings may help for future studies in order to design the potent and selective inhibitors of MAO-B. Furthermore, the current studies suggested new findings for MAO-B inhibitors, especially for aging based neurodegenerative diseases. The searched and screened compounds emerge to be promising scaffold and may be used for the drug design and development for the targeted neurodegenerative diseases.

For more articles in Journals on Biomedical Sciences click here bjstr

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[seagullcharmer]

does that [let's take ibuprofen together!] meme again but it's selegiline holding out a tiny vicodyn

[inceptionanalysis]

Overall, it seems very likely that SBF’s propensity to take extreme levels of risk was elevated to preternaturally high levels via heavy, habitual usage of amphetamines and selegiline, causing him to rationalize nonsensical strategies as optimal via convoluted “linear wealth utility” reasoning.

[ask-a-vetblr]

for a ccd dog, which medicine / supplement has better results longterm, Choline or selegiline? would omega 3 alone not be enough to help my dog? she paces at night / restless, doesnt stay too long in one spot day or night, easily startled, very clingy, appears to look down & see things that arent there, quiet when she is normally much more vocal. thank you so much for your help. we hadnt got to take xrays yet, unsure if its chronic pain or ccd :( shes a 12 y/o pomchi

mod @the-kazoo-kid

[seagullcharmer]

also since my friend lin has been drawing + talking abt dnd characters i need to sit down and draw ref sheets of my dnd characters so i can commission them

[mcatmemoranda]