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biatconsultant · 4 months ago

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The Impact of RNI Registration on Your Newspaper’s Credibility

In the bustling world of Indian journalism, establishing credibility is crucial for any newspaper or periodical. One significant step towards achieving this is securing registration with the Registrar of Newspapers for India (RNI). This process, while seemingly administrative, has profound implications for the credibility and trustworthiness of your publication. In this blog, we will explore the impact of RNI registration on your newspaper’s credibility, the RNI registration process, and the importance of maintaining a valid RNI registration status.

What is RNI Registration?

The Registrar of Newspapers for India (RNI) is a statutory body under the Ministry of Information and Broadcasting. It was established to facilitate and regulate the publication of newspapers and periodicals in India. The primary function of the RNI includes the registration of newspapers, verifying circulation claims, and maintaining the register of newspapers in India.

Importance of RNI Registration

Legal Recognition: Obtaining an RNI certificate provides legal recognition to your publication. This certificate is a testament that your newspaper adheres to the regulations set by the Indian government.

Enhanced Credibility: An RNI-registered newspaper is perceived as more credible and reliable by readers, advertisers, and stakeholders. This registration acts as a mark of authenticity, ensuring that the publication meets the necessary standards and regulations.

Advertising Opportunities: Many government and private advertisers prefer or require newspapers to be RNI-registered. This expands the advertising opportunities for your publication, leading to increased revenue.

Protection of Title: RNI registration protects the title of your newspaper, preventing others from using the same or a similar name. This helps in establishing a unique identity for your publication in the market.

The RNI Registration Process

The process of obtaining an RNI certificate involves several steps:

Title Verification: The first step is to get the title of your newspaper verified and approved by the RNI. This ensures that your chosen title is unique and not already in use.

Filing an Application: Once the title is approved, you need to apply for registration. This application includes details about the publication, such as the language, periodicity, and area of publication.

Submission of Documents: Along with the application, you need to submit several documents, including a copy of the first issue of the newspaper, a declaration from the publisher, and an affidavit stating the particulars of the publication.

Payment of Fees: RNI registration fees must be paid at this stage. The fee structure may vary based on the type and frequency of the publication.

Inspection and Verification: The RNI may conduct inspections to verify the details provided in the application. This includes verifying the circulation claims and other relevant information.

Issuance of RNI Certificate: Upon successful verification, the RNI issues the registration certificate, formally recognizing your newspaper.

Maintaining RNI Registration Status

Once you have obtained the RNI certificate, it is crucial to maintain your registration status. This involves submitting annual statements, ensuring compliance with the regulations, and renewing the registration as required. An RNI registration consultant can assist in navigating these requirements, ensuring that your publication remains in good standing with the RNI.

Impact on Credibility

The credibility of a newspaper is built on trust, reliability, and adherence to ethical standards. Here’s how RNI registration enhances these aspects:

Trustworthiness: Readers are more likely to trust a newspaper that is RNI-registered as it signifies adherence to regulatory standards and ethical journalism practices.

Professionalism: RNI registration reflects the professionalism of the publication, showcasing its commitment to maintaining quality and transparency.

Ethical Standards: An RNI-registered newspaper is expected to follow ethical guidelines, thereby enhancing its reputation among readers and peers.

Market Positioning: In a competitive market, having an RNI certificate sets your publication apart, providing an edge over non-registered newspapers.

Conclusion

RNI registration is not just a legal formality but a significant step towards establishing and enhancing the credibility of your newspaper. From legal recognition and protection of title to increased advertising opportunities and enhanced trustworthiness, the benefits are manifold. By understanding the importance of RNI registration and maintaining a valid RNI registration status, you can ensure that your publication stands out in the crowded media landscape. Whether you are a new publisher or an established one, consulting with an RNI registration consultant can simplify the process and help you navigate regulatory requirements with ease.

By securing your RNI certificate, you are not only complying with the law but also reinforcing your newspaper’s commitment to quality journalism and ethical standards.

Read Our Other Blogs to Know More About RNI Registration

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DEMYSTIFYING RNI REGISTRATION FOR FOREIGN PUBLICATIONS: STAY UPDATED ON YOUR RNI REGISTRATION STATUS

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lecielconsulting · 2 years ago

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RNI Registration - Leciel Consulting.

Registration of newborn infants (RNI) is a requirement for all children born in India. The child can get vaccinated, get his or her birth certificate and passport did at the same time. In order to register, one needs to produce the following documents: The child’s Birth Certificate issued by the hospital.

#RNI Registration #Leciel Consulting.#Consulting firm #GST Registration

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reportwire · 3 years ago

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SpendMend Expands Platform for Managing RNI, Working Capital, and More for U.S. Hospitals

SpendMend releases updated platform to extend the value and reach of their Vendor Management Services solutions. Press Release – Oct 21, 2021 GRAND RAPIDS, Mich., October 21, 2021 (Newswire.com) – SpendMend, the leading provider of tech-enabled solutions to optimize the cost-cycle for the healthcare industry, announced today they have released a major platform upgrade for their Vendor…

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#consulting #Cost-Cycle #healthcare #HealthSystems #Hospitals #optimization #RNI #Solutions #SpendMend #VendorManagementServices #VMS #WorkingCapital

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loyallogic · 5 years ago

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All you need to know about Press Council of India

In this article, Komal Kumari of Lloyd Law College, Greater Noida writes about the Press Council of India. The article focuses on the various aspects of PCI constituted in 1966 and amended in 1978. This article highlights the present situation of PCI as a safeguard to the freedom of the press.

Media is considered as the fourth pillar of democracy, it is the eyes and ears of this society and ideally perform the function of a moral watchdog of the public interests. Correspondingly, proving to be the interpreter between the public and different organs of our government. For the proper functioning of this organ, it has to be independent and should be able to withstand the outside pressure and influence i.e., political parties and various other powerful organizations. Here comes into play the press council of India with the object of preserving the freedom of the press and of maintaining and improving the standards of press in India. It is the autonomous, statutory quasi-judicial body which was first constituted on 4th July, 1966 and started functioning from November 16 of the same year (resulting in celebration of National Press Day on this date) by the Parliament on the recommendations of the First Press Commission under the chairmanship of Justice J.R Mudholkar (then a Judge of Supreme Court).

First Press Commission

When the nation was struggling for independence, majority of the National Press were contributing towards the freedom struggle against the British government but as soon as India gained independence the national press started lacking and losing its objective. The Editors and Owners of the press started thinking of it as a tool for their personal interest, an ample amount of defamatory articles were directed against communities or groups, of indecency, vulgarity and personal attacks on individuals. Moreover, some sections of the press were involved in yellow journalism. Therefore, raising a need to mark the status of the press in order to check their malpractices and to keep professional standards high. The first press commission was appointed with these objectives in 1952.

As Mahatma Gandhi said, “The sole aim of journalism should be service. The newspaper is a great power, but just as an unchained torrent of water submerges the whole countryside and devastates crops, even so, an uncontrolled pen serves but to destroy. If the control is from without, it proves more poisonous than want of control. It can be profitable only when exercised from within. If this line of reasoning is correct, how many journals of the world would stand the test? But who would stop those that are useless? and who should be the judge? The useful and the useless must, like good and evil. go on together, and man must make his choice.”

Recommendations of the First Press Commission

The recommendation of the first press commission for the first time provided an idea of what a responsible press should be.

For the protection of the freedom of the press and to maintain high standards of journalism, a Press Council should be established.

For preparing the account of the press and the position of every year, there should be an appointment of the Registrar of Newspaper for India (RNI).

For protecting the small newspapers from the fierce competition there’s a need for the introduction of a price-page schedule.

Press Consultative Committee should be constituted for maintaining a cordial relationship between the government and the Press.

Implementation of the Working Journalists Act.

Establishment of a fact-finding Committee for evaluating the financial position of the newspapers and news agencies.

Newspaper Financial Corporation should be constituted for protecting the main principles of the freedom of the press and to help the newspapers against monopolistic tendencies.

Conversion of the Press Trust of India into a public corporation.

Indigenization of both capital and the staff especially at the higher levels and it was highly desirable that proprietarily interests in the publication should vest predominantly in Indian hands.

Achievements of the First Press Commission

The first Press Commission has some commendable achievements to its credit. The report provided various important measures regarding regulating the newspaper industry.

Press Council of India was established in the year 1966 for regulating the press.

Appointment of Registrar for Newspaper of India on July 1956 to prepare an account of the publications and titles.

The price-page was scheduled in 1956 but was shot down in court.

Press Consultative Committee was constituted in 1962.

Working Journalists Act came into existence in 1955, the working journalists and other newspaper employees (conditions of services) and Miscellaneous Provisions Act were set up.

Fact Finding Committee was set up on the financial position of the newspapers and news agencies which submitted its report on 14th January 1975.

Newspaper Financial Corporation was accepted in principle and on 4th December 1970, a Bill was also presented in the Lok Sabha, which lapsed.

Composition of the Press Council of India

The 1965 Act provided for 25 members in the council which was changed to 28 members as per the act of 1978. The term of the Chairman and the members of the Council is 3 years.

Accordingly, it is a 28 member committee with the Chairman. The 28 members are as per the following diagram:

Chairmans of press council of India

Chairman

Years of Service

Mr. Justice Chandramauli Kumar Prasad

November 25, 2014 – till date.

Mr. Justice Markandey Katju

October 5, 2011 – November 24, 2014

Mr. Justice G.N. Ray

May 19, 2008 – October 4, 2011

Mr. Justice G.N. Ray

March 11, 2005 – May 18, 2008

Mr Justice K. Jayachandra Reddy

August 8, 2001 – February 7, 2005

Mr Justice P B Sawant

August 8, 1998 -August 7, 2001

Mr Justice P B Sawant

July 24, 1995- August 7, 1998

Mr Justice R S Sarkaria

January 24, 1992- July 23, 1995

Mr Justice R S Sarkaria

January 19, 1989- January 23, 1992

Mr Justice A N Sen

October 10, 1985- January 18, 1989

Mr Justice A N Grover

June 16, 1982-October 9, 1985

Mr Justice A N Grover

April 3, 1979-June 15, 1982

Mr Justice N Rajagopala Ayyangar

May 4, 1968-December 31, 1975

Mr Justice J R Mudholkar

July 4, 1966-March 1, 1968

Functions of the press council of India

The main functions of the Press Council of India as per the objectives of the Press Council Act, 1965, are as follows:

Helping newspapers in maintaining their independence;

Building up a code of conduct for journalists and newspapers according to the high professional standards;

Ensuring that the newspapers and journalists maintain high standards of public taste and foster a due sense of both the rights and responsibilities of citizenship;

Encouraging the growth of a sense of responsibility and public service among all those engaged in the profession of journalism;

Reviewing any development which is likely to restrict the supply and dissemination of news of public interest and importance;

Reviewing such cases where assistance has been received by any newspaper or news agency in India from foreign sources, as are referred to it by the Central Government;

Promoting the establishment of such common service for the supply and dissemination of news to newspapers as may, from time to time, appear to it to be desirable;

Providing facilities for the proper education and training of persons in the profession of journalism;

Promoting the proper functional relationship among all classes of persons engaged in the production or publication of newspapers;

Studying developments that may lead towards monopoly or concentration of ownership of newspapers, including a study of the ownership or financial structure of newspapers, and if necessary, to suggest remedies.

Promoting technical or other research.

Doing such other acts as may be incidental or conducive to the discharge of the above functions.

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Hence, the main function of the Press Council of India is to check the media practice and to keep an eye on freedom of the press.

Powers of the Press Council of India

Powers of the Press Council is given in section 14 and 15 of the Press Council Act, 1965. Powers to censure are given in section 14 and some general powers are described in section15.

Power to censure : Section 14

This section provides that if a complaint is made to the council, the council would give the newspaper, news agency, editor or journalist concerned an opportunity of being heard and hold an inquiry as provided under the regulations of this act. The council would not entertain a complaint if in the opinion of Chairman there is no sufficient ground for holding an inquiry. But this section does not empower the council to hold an inquiry into any matter in respect of which any proceeding is pending in the court of law.

The decision of the council shall be final and shall not be questioned in any court of law.

General powers of the Council: Section 15

This section provides that for performing its function or for the purpose of inquiry, the council shall have the same powers throughout India as are vested in a Civil court while trying a suit under the Code of Civil Procedure, 1908. But, this cannot compel any newspaper, news agency, editor or journalist to reveal the source of any news or information published. Furthermore, every inquiry held by the council shall be deemed to be a judicial proceeding under sections 193 and 228 of the Indian Penal Code.

Press Council of India Complaint Procedure

U/S 14 of PCI:Complaint against newspaper, editor or journalist: A complaint with the Press Council can be filed by any person, if there is a breach of the recognized ethical standards of journalism by the publication or non-publication of a news-statement or article, cartoon, advertisement, etc which is published in a newspaper. The complainant firstly has to write to the editor of the newspaper drawing his attention towards what the complainant finds objectionable. This gives the editor the opportunity to deal with the matter and take the necessary steps as in many cases the facts are usually misinterpreted by the complainant, or there is an error which the editor is ready to admit and correct. If the Complainant is satisfied the matter ends here, but if he is not satisfied then he can take further steps which is to refer to the Press Council. The complaint should contain the name and address of the editor, journalist or newspaper against whom the complaint has been drawn along with this he has to state in what manner the particular news-article, statement, cartoon, advertisement, etc is objectionable within the meaning of Press Council Act,1978 and has to provide all the relevant particulars(copies of correspondence with the editor and a declaration that no proceedings are pending in any court of law).

As per the Press Council (Procedure for Inquiry) Regulations, 1979, the complaint has to be filed within two months in the case of dailies, news agencies, and weeklies. In all the other cases it has to be filed within four months.

U/S 13 of PCI

Complaint by a newspaper, editor or journalist regarding abuse to freedom of press: a complaint can be produced against the Government, Organization or any other individual encroaching on the freedom of the press. The complaint should contain all the details of the respondent as well as the alleged infringement and if the cause of action is a reprisal measure of any article, all the details need to be produced before the council.

As per the Press Council (Procedure for Inquiry) Regulations, 1979, the complaint has to be filed within four months from the date of cause of action, the Chairman can condone the delay if satisfied that a sufficient reason existed for such condonation.

Press Council of India reconstituted

The PCI was reconstituted for its thirteenth term on 16 March 2018 for three year term but the names under the category of medium newspapers were not announced as the matter is sub-judice.

Why is the category of medium newspaper sub-judice?

The decision of PCI to reject the nomination of Hormusji N Cama (owner of Mumbai Samachar weekly and member of INS) and Kalyan Barooah in the category of medium newspaper as ineligible led to a huge outcry by the working journalists, editors and various media houses that the Chairman of PCI has done a biased selection while reconstituting the 13th term of PCI, he has simply overlooked the precedents and has adopted such a measure through which he can keep out certain candidates and media houses. They considered the act as a violation of the freedom of the press and had raised doubts regarding the neutrality of this institution.

The Indian Newspapers Society moved the Delhi High Court regarding the decision of PCI on the rejection of the nomination of Cama. The HC has stayed the decision of PCI and has sought the response of PCI and the Ministry of I&B against the rejection of the mentioned nomination and also sought the response of Cama on this plea.

The Press Council Act, 1978

The new legislation providing for the establishment of the Press Council was enacted in the year 1978 with the same objective of preserving the freedom of the press, maintaining and improving the standards of Press in India. The new Act brought a few structural changes:

the body would now consist of 28 members,

furthermore, it provided a new process for the selection of the Chairman, which is by a Committee consisting of the chairman of the Rajya Sabha, the Speaker of Lok Sabha and an individual elected by the members of the council from among themselves.

The best feature of this council is the procedure of nominating the Chairman and other members, based on the research and experience of the working of the Council. It has totally been a non-subjective procedure that does not allow the interference or influence of the Government, any agency or any individual, however eminent or highly placed he/she may be.

The objects of this Council are almost the same with that of the Act of 1965, two new functions that were added are: (i) Undertaking studies of foreign newspapers, including those brought out by any embassy or any other representative in India of a foreign state, their circulation and impact; and (ii) undertaking studies as may be entrusted to the Council and to give its opinion in regard to any matter referred to it by the Central Government. Whereas, some of the few functions which were a part of the previous Act were not included in this new Act as they were thought to be herculean for the Council to perform i.e., (i)Promoting the establishment of such common service for the supply and dissemination of news to newspapers as may, from time to time, appear to it to be desirable; (ii)Providing facilities for the proper education and training of persons in the profession of journalism; (iii) Promoting technical or other research.

The other functions remained the same as in the Act of 1965.

Press Council of India as a Safeguard of Press Freedom

“Freedom of the press is a precious privilege that no country can forgo” – M. K. Gandhi

Safeguarding the freedom of press was the first objective of the Council but it has failed to protect the same. There have been various threats to the freedom of press, in the form of pressurizing or intimidating them for the views expressed in paper, coercing newspapers from publishing facts, group raids on newspaper offices by unruly mobs, filing of motivated cases against a journalist for the sole purpose of harassing & victimization, browbeating by police and ministers,being slapped with hefty defamation suits, etc. This situation has gradually developed as a culture in India. The simple motto being used for infringing the freedom of the press is by ‘it won’t be possible for you to kill the story, but storyteller can be silenced or suppressed’.

According to the report of the Committee to Protect Journalism on ��The global impunity index’, India has been ranked 14th on the list with 18 murders of journalists with impunity from 2008 to 2018.

Reporters Without Borders (RSF) has listed India at 138th on its World Press Freedom Index in 2018, enumerating the fear that journalists are being the targets of online smear campaigns who not only vilify them but also threaten them with physical violence. These are the few cases of ruthless murders indicating the problem of silencing the journalists:

The shooting of Gauri Lankesh: veteran journalist and editor, renowned for her criticism of right-wing extremism and communal violence was killed because of her Anti-Hindutva Stand.

Navin Nischal of Dainik Bhaskar for reporting on child marriage.

Sandeep Sharma for publishing stories on illegal sand mining and police corruption.

Shujaat Bukhari for his reporting on the situation in Kashmir.

In order to protect the Democracy there a need to protect the independence of the press and furthermore serious actions are required to be taken in such cases.

References

https://www.mkgandhi.org/mass_media.htm

http://presscouncil.nic.in/

https://thediplomat.com/2018/11/journalism-in-india-a-dangerous-pursuit/

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thachthanhnghi1 · 5 years ago

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Essay On Endangered And Endemic Species Of India

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savoir-entreprendre · 6 years ago

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Afrique : les risques liés à la nationalisation des ressources énergétiques et minières sont en hausse (Verisk Maplecroft)

Les formes indirectes de nationalisation des ressources énergétiques et minières sont en hausse en Afrique. Le constant a été fait par le consultant mondial en risques, Verisk Maplecroft, dans une étude publiée jeudi.

Verisk s’est, ici, appuyé sur son indice de nationalisme des ressources naturelles (RNI), qui mesure le risque d’expropriation, l’imposition de régimes fiscaux plus stricts et la…

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kuldeeppathak-blog · 6 years ago

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marketresearchinsight-blog · 6 years ago

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Antisense & RNAi Therapeutics Market Is Growing Rapidly Over The Forecast Period

San Francisco, 15 Nov 2018 - According to a report published by Grand View Research, Inc.; the global antisense and RNAi therapeutics market is projected to be worth around USD 1.81 billion by 2025. Rising use of antisense technology to study gene function for disease management is anticipated to propel market growth over the forecast period (2014 to 2025). This technology regulates expression of disease-causing genes allowing better management of diseases. In addition, increasing R&D for treatment of uncommon neurodegenerative diseases such as hereditary transthyretin amyloidosis (ATTR) is also expected to boost market in near future.

Rising collaborations between pharmaceutical companies and drug delivery service providers are anticipated to drive the market. Antisense therapeutics offer precise and effective gene silencing. Various gene silencing drugs are in late stages of development. Adoption of antisense therapeutics to overcome challenges such as unspecific modes of action and delivery-associated complications are also expected to support market growth in the forthcoming years.

Access Full Insights On Antisense & RNAi Therapeutics Market: www.grandviewresearch.com/industry-analysis/global-antisense-and-rni-therapeutic-market

Advancements in personalized therapies based on antisense technology are expected to further propel market expansion. Development of nanotechnology-oriented procedures are expected to create more opportunities in the market. However, issues related to delivering drugs to desired site is the key challenge for market growth. In addition, inevitable toxic effects associated with the antisense and RNAi therapeutics may further hinder the adoption of this technology.

The worldwide antisense and RNAi therapeutics market can be segmented on the basis of technology, application, route of administration, and region. Based on technology, the market can be categorized into RNA interference and antisense RNA. In 2016, RNA interference technology held the largest revenue share due to various advantages of the technology. The RNA interface segment is further bifurcated into Small Interfering RNA (siRNA) and microRNA (miRNA). MiRNA is used to attain deeper understanding related to cancer metastasis as it involves in maintaining identity of cells. SiRNA enables induction at advanced stages of cancer growth as compared to chemotherapy. Thus, adoption of RNAi therapy to target Single Nucleotide Polymorphisms (SNPs) in genetic disorders is likely to propel market during the forecast period.

As per application, the market can be characterized into oncology, cardiovascular, respiratory disorders, renal diseases, neurodegenerative disorders, genetic disorders, infectious diseases, and others. Oncology is anticipated to continue witnessing significant growth over the forecast period due to existence of significant pipeline for cancer therapies. Demand for effective tumor targeting vectorization systems and multiple genes targeting oligonucleotide drugs is expected to grow as nanoparticle systems are affected by inter- and intra-tumor heterogeneity.

On the basis of route of administration, the market for antisense and RNAi therapeutics can be divided into pulmonary delivery, intravenous injections, intradermal injections, topical delivery, intraperitoneal injections, and others. Several studies are being carried out to reduce problems associated with rapid drug elimination without desired pharmacological action. This factor is expected to drive R&D in intravenous injections during the forecast period. Liver is considered as an ideal target for evolving technologies and can be targeted easily by intravenous route. High prevalence of liver disorders like hepatitis B and hepatitis C is likely to drive demand for RNAi therapeutics and antisense nucleotides over the forecast period.

Geographically, the market can be divided into North America, Europe, Asia Pacific, Latin America, and Middle East and Africa. North America is considered as a key market due to the presence of pipeline RNAi therapeutics in U.S. Several drug applicants under clinical trials have revealed favorable results and are rolling through the development phases. This factor is anticipated to boost regional market over the forecast period.

Prominent companies operating in the antisense and RNAi therapeutics market include Enzon Pharmaceuticals Inc.; Bio-Path Holdings Inc.; Sirnaomics Inc.; Bio-Path Holdings Inc.; and Benitec Biopharma Ltd. Investments in R&D and collaborations remain the key strategies adopted by major market players to attain greater market share. Most companies are also adopting mergers and acquisitions to maintain dominance over other players. This factor is projected to create business opportunities in the forthcoming years.

Access More Reports Of The Same Category: www.grandviewresearch.com/industry/pharmaceuticals

Grand View Research has segmented the global antisense and RNAi therapeutics market on the basis of technology, application, route of administration, and region:

Antisense & RNAi Therapeutics Technology Outlook (Revenue, USD Million, 2014–2025)

RNA Interference

siRNA

miRNA

Antisense RNA

Antisense & RNAi Therapeutics Application Outlook (Revenue, USD Million, 2014–2025)

Oncology

Cardiovascular

Respiratory Disorders

Renal Diseases

Neurodegenerative Disorders

Genetic Disorders

Infectious Diseases

Other

Antisense & RNAi Therapeutics Route of Administration Outlook (Revenue, USD Million, 2014–2025)

Pulmonary Delivery

Intravenous Injections

Intradermal Injections

Intraperitoneal Injections

Topical Delivery

Other Delivery Methods

Antisense & RNAi Therapeutics Regional Outlook (Revenue, USD Million, 2014–2025)

North America

US.

Canada

Europe

Germany

UK.

Asia Pacific

Japan

China

Latin America

Brazil

Middle East & Africa

South Africa

Browse Press Release of this Report: www.grandviewresearch.com/press-release/antisense-rnai-therapeutics-market

About Grand View Research

Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.

For More Information: www.grandviewresearch.com

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monaligvr-blog · 6 years ago

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Antisense & RNAi Therapeutics Market Coming To Reach $1.81 Billion By 2025 | Leading Players Marina Biosciences, Benitec Biopharma

San Francisco, 8 October 2018 - According to a report by Grand View Research, Inc., global antisense & RNAi therapeutics market is anticipated to value USD 1.81 billion by 2025. Growing requirement of advanced and effective therapeutics to address rising cases of chronic disorders globally is anticipated to propel demand for antisense & RNAi therapeutics. Antisense technology is likely to offer an opportunity for manipulation of gene expression for treatment of several diseases. It can be used to study gene function for disease management by regulating expression of disease-causing gene.

Continual R&D for treatment of uncommon neurodegenerative diseases such as hereditary ATTR amyloidosis can influence growth of market. Development of antisense therapeutics to overcome challenges related to unspecific modes of action and delivery-associated complications can augment market growth over next few years.

Difficulty in delivering drugs to specific site is expected to become major challenge for use of antisense and RNAi. Drug delivery to nervous tissues can be tough as the drug is supposed to pass blood-brain barrier. In addition, inevitable toxic effects of using these therapeutics can further restrict growth of market over the forecast period. It is necessary to determine right dosage and composition of antisense molecule to reduce Huntington's disease (HD) symptoms and avoid side effects.

Browse Research Report On Antisense & RNAi Therapeutics Market : www.grandviewresearch.com/industry-analysis/global-antisense-and-rni-therapeutic-market

The antisense & RNAi therapeutics market can be segregated on the basis of technology, application, route of administration, and region. Based on technology, the market can be categorized into RNA interference and antisense RNA. In 2016, antisense RNA segment dominated the market and accounted for largest market share over the forecast period. Growing use of antisense oligonucleotides to treat neurodegenerative disorders is expected to fuel growth of segment. In addition, implementation of various approaches for prevention of disease onset or halting progressions can influence growth. Diseases such as spinal muscular atrophy and amyotrophic lateral sclerosis are expected to show positive results with use of antisense technology.

Based on application, the market can be classified into oncology, cardiovascular, respiratory disorders, renal diseases, neurodegenerative disorders, genetic disorders, infectious diseases, and other. Oncology segment is expected to contribute maximum towards growth of market over next few years. Rising cases of eradication disorders such as cancer, HIV, and other mutating viral diseases can augment use of oligonucleotide products. Growing number of clinical trials for oligonucleotide drugs are likely to exhibit growth of segment. In addition, high prevalence of significant pipeline for cancer therapies by companies and institutes can boost segment growth over the forecast period. Moreover, R&D in nanocarriers for oligonucleotide delivery can contribute well to cancer treatment. These nanoparticles can be used to reduce toxicity.

Based on route of administration, the market can be divided into pulmonary delivery, intravenous injections, intradermal injections, intraperitoneal injections, topical delivery, and other delivery methods.

Regional segmentation includes Europe, North America, Asia Pacific, Latin America, and Middle East & Africa (MEA). In North America, the market is expected to witness significant growth over the forecast period. Rising number of RNAi therapeutics currently under developmental pipeline in United States can augment growth of market. Big pharmaceutical developers are likely to enter into collaborations and licensing deals with other smaller firms to boost revenue generation. This, in turn, can fuel market growth over next few years.

Since the discovery of RNAi, there have been efforts to improve treatment methods using RNAi. However, complexities in delivery methodologies associated with RNAi is expected to slow down growth of market. Development of new nanotechnology-oriented methods are likely to re-infuse the market with growth potential during the forecast period.

Moreover, rising number of drug candidates under clinical trials are expected to show favorable results and can progress through development process. This, in turn, can augment market growth over the forecast period.

Some of the leading companies offering antisense & RNAi therapeutics are Olix Pharmaceuticals, GlaxoSmithKline Plc, Alnylam Pharmaceuticals, Benitec Biopharma Ltd., and Antisense Therapeutics Limited. These players are expected to be involved in development of RNAi therapies and platforms that can offer diagnostics, medicines, personalized treatment options for key diseases.

View more reports of this category by Grand View Research at www.grandviewresearch.com/industry/pharmaceuticals

Grand View Research has segmented the global antisense and RNAi therapeutics market on the basis of technology, application, route of administration, and region:

Antisense & RNAi Therapeutics Technology Outlook (Revenue, USD Million, 2014 - 2025)

RNA Interference

siRNA

miRNA

Antisense RNA

Antisense & RNAi Therapeutics Application Outlook (Revenue, USD Million, 2014 - 2025)

Oncology

Cardiovascular

Respiratory Disorders

Renal Diseases

Neurodegenerative Disorders

Genetic Disorders

Infectious Diseases

Other

Antisense & RNAi Therapeutics Route of Administration Outlook (Revenue, USD Million, 2014 - 2025)

Pulmonary Delivery

Intravenous Injections

Intradermal Injections

Intraperitoneal Injections

Topical Delivery

Other Delivery Methods

Antisense & RNAi Therapeutics Regional Outlook (Revenue, USD Million, 2014 - 2025)

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

Browse Press Release of this Report: www.grandviewresearch.com/press-release/antisense-rnai-therapeutics-market

About Grand View Research

For More Information: www.grandviewresearch.com

#Antisense & RNAi Therapeutics Market Antisense & RNAi Therapeutics Market Analysis Antisense & RNAi Therapeutics Market Forecast Antisense

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enterslice-blog · 6 years ago

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vandykecarolpdrf7 · 7 years ago

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The Importance of Potassium in Low-Carb Diets

What is Potassium and why is it needed?

Potassium is one of the main electrolytes within the body. Along with sodium and chloride, potassium is responsible for maintaining electrolyte balance. Electrolytes are responsible for sending electrical impulses around the body. Specifically, potassium assists in a range of essential bodily functions including: (1).

Water balance

Blood pressure control

Muscle contractions

Digestion

Heart rate and rhythm

pH balance

Normal Ranges in the Body

The average content of potassium in adults is 40-50 mmol (1.6-2.0 g)/kg of body weight (2). Someone who weighs 65 kg would therefore have a level of 2600-3250 mmol in their body.

The concentration of potassium is greater within the intracellular fluid (150 mmol/L) with the remainder in the extracellular fluid (3.5-5.5 mmol/L) (2).

The amount of total potassium is directly related to the level of lean tissue mass. As men generally have greater lean muscle mass, they have a greater level in the body.

Testing of potassium levels is done within the blood. This means it is testing the extracellular fluid and subsequently the normal ranges for the test will be between 3.5-5.5 mmol/L.

Recommended Intakes

The body cannot naturally produce or make potassium and so it needs to be obtained from the diet.

The recommended intakes vary between America and Europe. In the USA the Adequate Intake (AI) for adults is 4.7 g/day (4700 mg/d) and in Europe, the Reference Nutrient Intake (RNI) is set at 3.5 g/day (3500 mg/d) (3, 4). The lower reference nutrient intake (LRNI/ EMR), is the minimum amount that needs to be met within a day and is set at 2 g/day for adults (3).

As the levels are directly correlated with muscle mass, men may require a slightly higher dose.

Low and High Levels of Potassium

Various hormonal and other factors (including sodium levels), regulate potassium within the body. As with the other electrolytes, it is the role of the kidneys to regulate potassium balance.

Hypokalemia

Hypokalemia is when the body has low levels of potassium (<3.5 mmol/L). This can cause symptoms including:

Irregular heart beat

Muscle weakness or cramping

Glucose intolerance

Extreme fatigue

Constipation, nausea and/or vomiting

Developing such low levels generally should not happen if you are consuming enough potassium in your diet. However, a mild deficiency can be much more common causing symptoms including (5).

An increase in blood pressure

Increased salt sensitivity

Increased risk of kidney stones

Heart arrhythmias

Mild muscle cramping

Headaches

Hyperkalemia

Hyperkalemia is when potassium levels are too high in the body, classed as >7.5 mmol/L (6). This often only occurs when potassium intake exceeds 17.6 g/day which is usually done through supplementation. As well as excessive supplementation, certain medical conditions (such as kidney disease) and medications can cause high potassium levels.

The most common symptom of high potassium is abnormal heart beat. With the severest outcome being that of cardiac arrest (7).

Potassium Levels on a Low Carb Diet

In the first few weeks of starting a low-carb diet, the symptoms of the “keto-flu” can come into full effect. One of the major reasons for the symptoms occurring is due to a change in electrolyte balance. Potassium is one of those electrolytes that can be affected.

In the first few weeks, your body loses a significant amount of water. As this is processed through the kidneys this can then affect the electrolyte balance. Sodium is often the first electrolyte to be lost. Since potassium is closely related to sodium and because the kidneys control the levels, a drop-in potassium can also be experienced.

The symptoms of muscle cramps, heart arrhythmias and fatigue could be a combination of lower salt and subsequent potassium levels.

Therefore, ensuring you get adequate salt in your diet is important both for sodium and potassium balance and to alleviate any keto-flu.

Top 7 Potassium Rich Foods

Below is a list of the top 7 foods high in potassium that you should eat daily to hit your required levels.

1. Spinach

All dark green leafy vegetables offer an abundance of nutrients including spinach. One cup (180 g) of cooked spinach offers a significant amount of potassium at 839 mg (24% of RNI) (8). That is almost double what a medium sized banana offers in the way of potassium at only 422 mg!

Although spinach has one of the highest magnesium contents, other dark green leafy veg that offers a good source of magnesium include kale, swiss chard and broccoli.

2. Avocados

As well as providing a significant amount of healthy fats, avocados are also packed full of certain electrolytes and minerals.

Just one average avocado (136 g) contains 690 mg (20% RNI) of potassium (9).

3. Zucchini

Squash is a a great versatile vegetable that also carries with it, a relatively low carbohydrate content at just under 4 g (net carbs) per cup.

It is also relatively high in potassium with one medium zucchini (192 g) providing 512 mg (15%) (10).

4. Salmon

Salmon is best known for providing an excellent source of omega 3, but it is also packed full of other essential nutrients. Whilst providing a great source of the B vitamins and vitamin D it is also a good source of potassium. For a 3-oz serving it provides 416 mg (12% RNI) (11).

Other fish including cod, sea bream, monkfish, sardines, herring and mackerel also offer a good source of magnesium.

5. Beef

Often when people look at sources of potassium they list mostly fruits and vegetables but meat sources offer a significant amount of potassium as well. A 4-oz steak provides 384 mg (11% RNI) of potassium (12).

As well as beef, other meats (such as pork and lamb) and poultry (such as chicken and turkey) also offer a good level of magnesium.

6. Mushrooms

Mushrooms make a great base for many low-carbohydrate dishes and can be a great option for those following more of a plant based low-carbohydrate diet. They are known for being higher in vitamin B12 as well as having a great antioxidant capacity which can help fight free radicals (13).

Whilst all mushroom do have a higher potassium level, just 1 cup (72 g) of crimini mushrooms have the highest at 323 mg (9% RNI) (14).

7. Cauliflower

Cauliflower is a cruciferous based vegetable and is extremely nutrient dense, including having a high antioxidant profile in sulfur-containing compounds. One cup (107 g) contains 320 mg of potassium (9% RNI) (15).

Other Sources of Potassium

Nuts and seeds are a great staple within a low carbohydrate diet providing sources of good fats, protein and certain minerals. Almonds offer the highest potassium content out of all the nut options with 1 oz (28 g) providing 200 mg (6% RNI) (16).

Beets are often classed as a superfood as they are packed full of phytonutrients that act as powerful antioxidants. As well as being high in both folate and manganese, it is a great source of potassium. One cup (136 g) provides 442 mg (13% RNI) (17). Since they contain more carbs than other vegetables, they should be eaten in moderation if you follow a low-carb diet.

Supplementation

Due to the risk of developing Hyperkalemia (high potassium levels), supplements are rarely sold with a content of more than 85 mg. Before ever supplementing with potassium, you should always consult with a health professional (18).

Some people find that supplementing with a small amount of potassium chloride within the day can help with any side effects of low potassium in the diet. A dose of around 20 mEq dissolved in a glass of water and taken with food 1-2 times per day can help with any symptoms of low potassium levels (19). It needs to again be stressed here that if you are unsure of your levels, you must consult a health care professional to recommend on the levels.

If your low carbohydrate diet is well formulated with foods containing potassium (as listed above) then you should not need to supplement.

However, in the first couple of weeks when you are experiencing keto-flu, the water loss may cause an imbalance in both sodium and potassium. To help with any of the side effects, taking 1-2 teaspoons of lite salt (which is 50% sodium chloride and 50% potassium chloride) per day can be of benefit. If the side effects still persist then adding in the above potassium chloride supplement may also help.

Take Home Message

Potassium is an essential electrolyte which often becomes more essential on a low carbohydrate diet. Ensuring that you get the recommended intake through your diet will make sure that you reach the adequate intake.

If the symptoms of muscle cramping and heart arrhythmia continue then taking in a 1-2 tsp of lite salt per day can help alleviate this. Always be sure to get any blood levels checked before ever supplementing with potassium.

Potassium Rich Keto Recipes

Below is a collection of KetoDiet recipes that are packed full of potassium:

Keto Pork & Kohlrabi Stew, 1778 mg

Stuffed Avocados, 800 to 1400 mg

Keto Beef Stroganoff Soup, 1406 mg

Quick & Easy Eggs Benedict, 996 mg

Beef, Spinach & Mozzarella One-Pot Bake, 899 mg

Easy Avocado & Egg Salad, 875 mg

Spicy Keto Salmon Burgers with Lemony Kale, 850 mg

Keto Zucchini Breakfast Hash, 691 mg

Keto Breakfast Sausage & Guac Stacks, 775 mg

Goat Cheese & Spinach Salad Bowl, 541 mg

Paleo Spinach Tabbouleh, 525 mg

Low-Carb Zucchini Apple Pie, 515 mg

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#The Importance of Potassium in Low-Carb Diets

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semilane · 7 years ago

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marketresearchinsightsrepor-blog · 8 years ago

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Antisense and RNAi Therapeutic Market is expected to boost lucrative growth rate during the forecast period

Global antisense and RNAi therapeutic market is expected to witness a lucrative growth rate during the forecast period owing to rising prevalence of infectious diseases, and coronary heart disorders which lead to cardiovascular diseases. Incorporation of technologically advanced RNA based technologies such as RNA antisense; RNA nanobiotechnologies, RNA interference, and SMaRT technology are also expected to drive market demand. Furthermore, growing needs for high throughput therapeutic tools for treatment of neurometabolic disorders such as amyotrophic lateral sclerosis, Huntington’s disease and Alzheimer’s disease, and rising awareness regarding tissue specificity for drug delivery about RNA based drugs are factors expected to fuel the growth for gene synthesizing mechanisms & cellular gene silencing. However, huge investment requirement in drug delivery & research and high treatment success rates are some factors that are expected to boost market growth.

To request a sample copy or view summary of this report, click the link below: http://www.grandviewresearch.com/industry-analysis/global-antisense-and-rni-therapeutic-market

Further key findings from the study suggest:

Increasing awareness towards the use of aptamers and ribozymes for suppression of target genes, and there selective expression in order to treat diseases at a genomic level prior to protein expression is also expected to promote the market growth. Increasing usage of RNAi technology based therapeutics for infectious diseases such as HIV, viral hepatitis and cancer in order to overcome the adverse effects observed by consumption of generic drugs and inhibit the metabolic growth of causative micro-organism are expected to drive demand for antisense & RNAi therapeutic market through to 2022. Furthermore, approval of different novel drugs for the treatment of cholesterol associated disorders and ocular diseases are anticipated to have a positive impact on the growth of this market in the coming seven years.

The geographical analysis of antisense & RNAi therapeutic market divides it into Europe, North America, Asia-Pacific, Latin America and MEA. North America held the largest share in market revenue in 2014 as a consequence of rise in incidence of cardiovascular, genetic and neurometabolic disorders. Other factors contributing towards large market share of the region include rise in number of R&D institutes and laboratories involved in development of bioinformatics based research for disease prognosis. However, Asia Pacific region with emerging economies such as India and China is expected to grow at a significantly faster rate in the RNAi and antisense therapeutic market. Factors attributing this anticipated growth of this region include presence of unmet market demand, and increased used of miRNA as a disease marker for oncology diseases. Furthermore, presence of many antisense and siRNA molecules in the pipeline for drug development under clinical trials for regulatory approval is expected to fuel the market growth during the forecast period. Key participants in the market include Sanofi, Allergan, Benitec Biopharma, Biogen, Atlantic Pharmaceuticals, Inc., Enzon Pharmaceuticals Inc., AstraZeneca, Bristol-Myers Squibb, Acuitas Therapeutics, Glaxosmithkline, Isis Pharmaceuticals, Dicerna Pharmaceuticals, Antisense Therapeutics, Dainippon Sumitomo Pharma, Roche Holding AG and Tekmira Pharmaceuticals. Competitive strategies adopted by the market players include collaborations for development and commercialization of antisense and RNAi drugs in the pharmaceutical and biotechnological market.

See More Reports of This Category: http://www.grandviewresearch.com/industry/pharmaceuticals About Grand View Research: Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare. Contact: Sherry James Corporate Sales Specialist, USA Grand View Research, Inc Phone: 1-415-349-0058 Toll Free: 1-888-202-9519 Email: [email protected] Web: www.grandviewresearch.com

#Antisense and RNAi Therapeutics Market #Healthcare

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grandviewresearchinc-blog · 8 years ago

Text

Antisense and RNAi Therapeutic Market is expected to boost lucrative growth rate during the forecast period

To request a sample copy or view summary of this report, click the link below: http://www.grandviewresearch.com/industry-analysis/global-antisense-and-rni-therapeutic-market

Further key findings from the study suggest:

#Antisense and RNAi Therapeutics Market #Healthcare

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