#renal properties

[ms-demeanor]

If you're new to me yelling about this: my neighbors feed a feral cat colony but provide no other care to the colony like neuter/spay or vaccination. They free feed the cats, which attracts skunks, and they have (at the moment) about 20 cats in the colony, which attracts coyotes.

My dog has been skunked twice, she can't be outside in our yard unsupervised for even a minute because otherwise she'll try to eat cat shit because there's cat shit everywhere in my yard because the neighbors also haven't provided litterboxes or a sandbox for their ferals (their entire yard is paved) and if she has to go outside at night I need to clear the yard for coyotes before I let her out even in the small fenced area by our bedroom.

Also there are fleas fucking *everywhere* and even though my dog is on medication to prevent fleas I need to de-flea her twice a week in the summer; this is the case for every dog owner on the street.

The street I live on has a speed limit of 25mph but I hear cats getting hit frequently, so frequently that we have a resident group of crows who hang out and wait for them to become roadkill.

I have a collection of photos on my phone that show kittens with broken legs, kittens with missing eyes, kittens with horrible ear mite infections, and I have a dedicated shovel that I use for moving cat corpses that show up on my property. The cats that die on my property die from abscessed wounds from fights with other cats, respiratory infections, renal failure, and injuries from being hit by cars.

My spouse is immune compromised, and while toxoplasmosis is not a serious risk for most people, it IS a serious risk for people who are immune compromised (as are all the other infections that cats can potentially carry), which means that it's unsafe for me to grow vegetables in my yard for us to eat and it's unsafe for him to work in the yard.

I'd love to maybe open my windows at night and keep down the electricity costs of using the AC, but I can't because the entire side of my house that faces my neighbor's yard reeks of cat shit and piss year round.

Those are my next door neighbors.

Last week I was walking my dog as a neighbor around the corner was pulling out of her garage; she paused and rolled down her window and pointed at the cats on her lawn and said "Head's up, my cats are weirdly aggressive about small dogs and they just got let out so they're full of energy right now" and I nodded and crossed the street and didn't yell at my neighbor but *the temptation was there* because A) why are you letting your aggressive animals roam and B) Why are you letting your cats shit all over the neighborhood and C) Why are you exposing your owned cats to the risks of the large and territorial feral colony that is a literal stone's throw away from your house?

Anyway, and as always, Keep Your Fucking Cats Indoors.

[raviollies]

Vampire world biology rambling ft. Lorelai

Vampires "live" through the interaction of necrotic energy allowing them to ambulate. For this reason, despite the common misconception, vampires do have a heartbeat, it is however extremely slow, most accurately being compared to an Agonal rhythm (around 10 BPM), purely for the sake of circulating this energy through the vehicle of blood. Since most of the vampires organs have atrophied (their digestive, reproductive and renal systems), blood circulation is purely to facilitate the energy reaching all extremities and to discourage blood pooling, and causing swelling.

Since their digestive tracts are atrophied, vampires cannot digest food, and have to get their "nutrition" through liquid means. In order to replenish their unique homeostasis, they must consume the living force of other creatures, the more intelligent creatures leading to a much better ratio of blood to potential energy. Sickness, age, lifestyle and nutrition affect the potential energy that can be found within an organism, thus vampires typically seek out younger, healthier individuals, but rarely children due to their small size. Because of this, vampires do not need to feed as regularly if they consume blood from sapient, and go several days up to weeks without feeding (Akin to reptiles).

As such, since the vampire cannot eat meat to consume the energy, they must stick to bodily fluids, the easiest and easiest to replenish being blood, but things like CFS would also work. Occasionally starving vampires eat meat in desperation, but that is a lost cause as, they are forced to regurgitate it as they cannot digest it (Like Owl pellets). This usually only happens to 'feral vampires' - so lost in their hunger they step over their inhibitions and cave into pure instinct to get *something* to fill their belly.

Another system, while not fully atrophied, but heavily impacted is the nervous system causing vampires to experience Analgesia (Lack of Pain). They can feel sensations, however they are extremely muted. To feel cold a vampire must be in extremely freezing conditions, to feel warm they must be quite close to a flame, to feel pain they must sustain heavy damage etc.etc. This has an adverse effect on the psyche, and it is quite common for vampires to experience depression upon becoming undead.

But just because their body is dead does not mean it is impervious to damage. Their regenerative properties are part to none - Vampires still have to care for their bodies just as much as mortals, as due to their lack of an immune system, while they cannot fall ill, their body can still house fungi or bacteria that promote decomposition which while not a death sentence, is a promise of a painful and gruesome future.

In the sun, vampires burn, but not akin to a thermal burn, but rather chemical burn. There is no flame, but the sizzling of flesh, due to a unique interaction of necrotic forces and sunlight. As long as there is no direct sunlight on exposed flesh, the vampire can walk in the sun, however such a feat is quite difficult as it would involve covering ever single inch of your skin, most likely outing yourself as undead -hence why most prefer to simply rest during the day. Sunlight and holy forces are the only things that can scar a vampire.

How does Lorelai deal with the above?

Lorelai is still very young as far as Vampires go, only being one for several years, so many of the psychological long term effects remain a mystery to her.

She does require regular consumption of blood but she is acutely aware that by biting her companions, she would be putting them at a disadvantage for her own...he avoids it as much as possible (Only on extremely rare occasions will she feed from the wrist - never the neck because she finds that too intimate but that's for another post). Whenever the party buys ingredients for food, they also buy Pig's blood for her - a fairly innocuous and easy to acquire ingredient. When hunting, she is given time before the animal is butchered to drink. Since she mostly drinks of animals, she has to feed much more frequently, so it's common for her to be having her 'food' along with the party for dinner nightly.

She always had a soft spot for various fruits, with mangos being her favourite, so she indulges in tiny quantities of mango juice on special occasions.

Lorelai does feel the temperature difference very acutely, as I mention before she enjoys staying in her bat form to warm up by the fire or in various people's beds due to the much smaller size of body. She is fine without the cold.

She does have a lot of issues as I went over here about Analgesia, and how it impacts how she feels pleasure as well - so she is working through that, but she misses the positive sensations of when she was alive, feeling something soft or fluffy. To hold a warm cup. She however is not one of those people that wax poetically about how even pain she misses.

In general Lorelai isn't...someone that hates being a Vampire. Ultimately she wouldn't go back. She doesn't mind being tied to the night than the day, after all, most people rest during the night and miss the things that happen there (and with Raha only needing 4 hours of sleep and Blythe not needing sleep at all, she doesn't feel lonely). She enjoys that she feels full of energy at all times, that she can't get hurt as easily, that she is free to do what she wants. Vampirism to her was...the open door to freedom, to acceptance of what she wanted to do. She'd never want to go back (even if Raha continues to search for a cure for her. Even if she doesn't take it...at least this time she can make the choice to stay a Vampire)

[chasindbae]

Due to the overwhelming popularity of the Nuka-Berry mixture available in Nuka World, an exclusive run of Nuka-Berry was distributed in select markets and advertised in in magazines directed at upper-class women, such as SteelBarn and Publishing Clearance Home. Implied to be a cool, refreshing drink with sophisticated taste, the popularity of the drinks created a gap in the market which lead to resellers making excess profit, much to the displeasure of the greater public and the Nuka-Cola Company and its affiliated properties. Official Nuka-Berry would never be distributed again beyond its initial release, due to claims that the intense, glowing pink drink had caused the death of a woman in renal recovery who was reported only to have tried the drink. Many reports of renal damage in healthy individuals and rumors that the product turned a person's urine a concerning red, lead to the shut down of the project. A hand painted commission for the wonderful @juneiper-art of her Lone Wanderer Quinn. I wanted to do a Nuka-Cola ad with those pink curls and I'm delighted with how it came out. I hope to do more stuff like this!

edit!!: commissions still open bby! 🏄🏼‍♀️

[dmvcannabisdeliverysblog]

Do Weed Edibles Make You Dehydrated? (What Experts Say)

Do you ever experience dry skin, mouth, or other dehydration symptoms while consuming Cannabis? Does that ever concern you? If so, you are not alone. Many people have certain concerns while trying new stuff, especially when it is drug-related, whether it is for pleasure or pain management. But is it really the truth or a myth? Do weed edibles dehydrate you? We will explore it in this article.

What is Dehydration?

It is the absence of enough fluids or water in the body. Dehydration occurs when your body loses more fluids than it takes in. Your body won’t work properly if the lost fluids aren’t replaced as soon as possible.

Usually, thirst is our body’s way of telling us we need to drink water. It has been shown, nevertheless, that thirst alone isn’t necessarily a good sign of hydration. Many people don’t feel thirsty until they’ve already lost a lot of fluid, which is especially typical in older people. In general, it’s a good idea to increase water consumption whether you’re sick, it’s hot outside, or you’re exercising.

Dehydration signs are obvious, such as darker urine and a considerable reduction in urination. Dehydration can also be indicated by less obvious symptoms like fatigue or lightheadedness, which can occasionally resemble the consequences of using Cannabis. It can also appear as a dry scalp or skin.

Dehydration results from regular biological functions that cause us to lose water, such as breathing, sweating, peeing, and producing saliva. Dehydration results from not drinking enough water to replenish these losses.

Dehydration can occasionally happen accidentally. Lack of thirst, being preoccupied with other things, not feeling thirsty, or even being under the influence of Cannabis can all cause dehydration.

Read More: How Long Do Weed Edibles Stay in Your System?

Why Does Cannabis Dry Mouth?

Cannabis users frequently suffer from “cotton mouth,” a drying sensation in the mouth that is also associated with dehydration. The dryness that follows smoking, meanwhile, doesn’t always indicate dehydration.

Cannabis use does not automatically dehydrate you, but dehydration symptoms like dry mouth, lightheadedness, and dizziness, which are typical of a “weed hangover,” might be mistaken for these symptoms.

Contrary to claims of dehydration, Cannabis itself doesn’t significantly disturb the natural balance of water. However, actions like consuming alcohol and Cannabis together might cause dehydration and other problems.

Although Cannabis does not normally result in dehydration, a small percentage of long-term users may have a disease known as cannabinoid hyperemesis syndrome (CHS). CHS develops in phases, resulting in vomiting, dehydration, weight loss, and nausea. The only CHS therapy that works and results in complete recovery is ceasing to consume Cannabis.

But Is Cannabis Dehydrating Your Body?

Does Cannabis dehydrate? Yes, it does. Cannabis has dehydrating properties because of its diuretic properties, which encourage urine production and, therefore, increase water excretion.

Fundamentally, increased renal function can cause the body to feel dry when using Cannabis without maintaining enough water consumption. This effect is especially prominent in the case of edibles since the prolonged period of increased urine lasts for several hours due to their slow digestion.

Read More: Do Weed Edibles Smell? The Truth Revealed

What Can Be Done to Avoid Dehydration?

You can use the below-mentioned tips in order to avoid dehydration after consuming the weed edibles.

1. Maintain Hydration

Staying hydrated is essential, especially while using Cannabis. This means drinking enough water before, during, and after using Cannabis. You may prevent the possible dehydration effects of Cannabis by intentionally ingesting enough water. The body’s natural systems are supported by enough hydration, which also helps counteract water loss from cannabis’ diuretic effects.

2. Choose a Balance Diet

Diuretic intake must be balanced; therefore, paying attention to what you’re eating is important. The drying effects of Cannabis can be exacerbated by meals high in salt and beverages like coffee and alcohol. These drugs promote increased urination, which amplifies water loss. Maintaining optimum water levels can be greatly helped by monitoring and controlling your consumption of certain diuretic substances.

3. Exploring Cannabis-Infused Drinks

If you like edibles, choosing cannabis-infused drinks might be a smart move. These drinks give a hydration benefit in addition to the desirable cannabis benefits. Contrary to certain conventional ways of ingestion, cannabis-infused beverages increase your fluid intake and help you stay hydrated as you experience the effects of the drug.

4. Quickly Responding to Dehydration Symptoms

It’s crucial to spot early indications of dehydration. A few examples are a dry mouth, increased thirst, darker urine, or a feeling of exhaustion. The dehydration effects of Cannabis can be fought off by increasing water intake as soon as these symptoms appear. You may avoid the pain and potential health problems related to dehydration by practicing proactive hydration.

5. Factors Affecting Dehydration Caused by Cannabis

The degree of dehydration brought on by Cannabis varies depending on a number of variables. These variables include the amount and kind of Cannabis used, as well as one’s metabolism, body composition, and general health. An overall feeling of dehydration can also result from other cannabis side effects, such as an elevated heart rate or dry lips.

Should You Get Advice from a Medical Professional?

It’s important to recognize that the relationship between Cannabis and a person’s physiology can be complicated. It is advisable to see a medical expert before making any big adjustments to your cannabis use, especially if you are worried about how THC may affect your body’s processes. Based on your health history, medical specialists can offer individualized guidance to make sure your cannabis use is in line with your general well-being.

Maintaining proper hydration while using Cannabis entails a proactive approach to water intake, mindful use of diuretics, consideration of alternative consumption methods like beverages infused with Cannabis, prompt response to dehydration signals, and consulting medical professionals to make educated decisions about your cannabis use.

Read More: How to Make Weed Edible Rice Krispie Treats?

Conclusion

Drinking a lot of water is essential while using Cannabis; however, there should be a healthy balance to everything. When the body stores an abnormally large amount of water, water intoxication can arise from excessive ingestion. Drinking a substantial volume of water in a short period of time can give birth to this issue. For instance, consuming 100 ounces of water in only a few hours might result in a number of risks, even lethal ones. Make careful to spread out your regular water consumption equally throughout the day to protect your health.

There are a number of sensible methods for keeping hydrated when using Cannabis. The cornerstone of preserving good health is moderation, along with a balanced lifestyle and nutrition. Since thirst may not always correspond to our real hydration needs, including hydrating drinks and plain water in your diet can help. In addition, maintaining sufficient hydration is a tried-and-true way to reduce the effects of a “weed hangover” the next day.

More Information please visit our online store :- https://dmvcannabisdelivery.com/

[ataleoftwopitties]

These past few years, I have become a huge advocate for feeding fresh food to dogs to enhance their lives. However, you don't exactly have to transition your dog to a 100% fresh food diet in order to gain the benefits of fresh food.

Simply adding fresh food to your dog's kibble can go a long way in improving their nutrition and overall health. For instance, one study done a group of dogs in 2005 revealed that feeding vegetables just three times a week had significantly lowered their risk of developing cancer, compared to dogs who were only fed kibble.

Asian markets, in particular, have some very beneficial fresh food items that aren't typically found at your local grocery store. These food items, however, are not intended to fully replace your dog's food. Remember - too much of something good can be bad for you.

Instead, they should be offered in moderation as treats, or just small amounts topped over an already complete and balance meal. As a general rule of thumb, treats/toppers should never make more than 10% of your dog's overall diet.

Bok choy (Chinese cabbage) is full of essential vitamins and minerals needed to support a dog’s eyesight, cardiac function, digestion, bone strength, and immunity. Sulfurophane - a compound found in bok choy and other cruciferous vegetables - has been linked to inhibiting cancer cell growth, lowering blood pressure, and activating the nuclear factor Nrf2 which prevents the development of diabetes and its complications. Bok choy’s low calorie, high fiber content also make it a good option for a snack/food topper for dogs who need to control their weight. 

Preparation: Lightly steam or boil for better nutrient absorption. Cooking will also help neutralize the enzyme (myrosinase) that can decrease thyroid function. You should also chop/trim their long leaves to avoid choking hazards.

Goji berries (wolfberries) are rich in amino acids, carotenoids which support healthy vision, and polyphenols that have anti-inflammatory, anti-tumor, and cardio-protective properties. Studies on goji berry supplementation in animals have shown that it has the potential to help lower cholesterol, protect the liver by increasing hepatic antioxidant activity, as well as enhance metabolic homeostasis and prevent diabetes-induced renal inflammation. 

Preparation: Remove stems if still attached and cut/mash berries. If dried, soak in water until softened to avoid passing straight through the GI tract and losing the benefits of its nutrients. 

Offal refers to the internal organs and variety meats of animals that can be consumed as food (i.e. lung, heart, kidney, liver, gizzard, head, feet, etc.) The word 'offal' literally translates to "fall off", and thus, whatever falls off the skeleton during the butchering process. Offal is densely loaded with essential vitamins, minerals, proteins, and fats - so small amounts go a long way. Pet owners who use these as ingredients as part of a complete and balanced recipe should keep in mind that each organ is unique in its nutrient profile - dependent on the animal it is sourced from and how it is raised. For example, grass-fed beef may contain less fat yet more vitamin A and E than grain-fed beef, and beef liver has significantly more vitamin A and copper than chicken liver.

Preparation: Boil in water or low-sodium broth. May also be baked or dehydrated into jerky treats.

Oyster mushrooms are a good source of protein and fiber, and vitamins that support healthy digestion. They can help to increase satiety and maintain healthy body weight. Oyster mushrooms are also full of pantothenic acid which help to maintain cognitive function and healthy skin/coat. Beta-glucans derived from oyster mushrooms have also been shown to reduce inflammation and strengthen immunity. 

Preparation: Lightly sauté or boil in water or low-sodium broth. Raw or dried mushrooms can be difficult for dogs to digest. 

Purple sweet potato (Ube or Okinawan sweet potato) are typically found in grocery stores more commonly during the fall/winter seasons. They contain more antioxidants than regular sweet potatoes due to the anthocyanins that cause their violet hue. While all potato varieties may impact blood sugar levels because of their high carbohydrate content, purple potatoes may exert less of an effect because of their high polyphenol content that decreases the absorption of starches in the intestines. In addition, they have been linked to improving blood pressure, likely due to their high potassium content. 

Preparation: Peel skin and bake until soft for better digestibility and to prevent intestinal blockages. May be boiled and drained to reduce oxalate intake for dogs with a history of bladder stones, or prone to urinary issues. 

Quail eggs are small, yet packed with protein and essential fatty acids, and have a higher ratio of iron, riboflavin, and vitamin b12 than chicken eggs. It is even safe and can be beneficial to feed them with the shells included for added calcium. Quail eggs have been linked to improving bone growth/healing, reducing liver damage, and increasing energy levels. While some studies have shown evidence of quail eggs treating allergies in humans and mice, they may be less likely to trigger reactions than chicken eggs in dogs who have poultry sensitivities.

Preparation: Wash thoroughly, and handle gently as they are more fragile due to their tiny size. Cooking methods are similar to that of chicken eggs, yet require less time. 

Sardines contain all the amino acids your dog needs for optimal health, making it a "complete protein". They are also notorious for being rich in omegas and coenzyme q-10, which help support heart and brain health. What sets sardines apart from other fish, too, is that they are smaller and more short-lived species than larger predator fish and may have less of a risk for mercury poisoning. Because they are so small and have soft bones, you can feed them whole to your pets.

Preparation: Bake or dehydrate. If already purchased as dried, be sure to make sure there is no added salt or seasonings. If canned, preferably those stored in water only.

Sushi rice (Japanese sticky rice) has a high proportion of starch and moisture, giving it a stickier texture when cooked. Sushi rice has virtually zero fat, yet still provides a desirable balance of nutrients while remaining gentle on a dog’s digestive tract. Its higher iron content than regular rice supports healthy blood circulation and can provide more energy to dogs who are recovering from illness. Cooling/refrigerating the rice before serving also enables more retrogradation of prebiotic fiber, helping to lower glycemic responses and maximize intestinal function.

Preparation: Rinse thoroughly and soak in water (with 1tbsp apple cider vinegar - optional) before cooking. If you don’t have a rice cooker or instant pot, boil on the stove until the water is completely absorbed. May be cooked with bone broth for added flavor. You can also use small amounts of beet root powder, turmeric, or blue spirulina to add color and nutrients.

[sac-bestsupplements]

Cistanche Deserticola vs Tubulosa? The Magical Cure for Fatigue, Impotence, and Memory Loss?

Discover the best Cistanche Supplements: https://super-achiever.com/best-cistanche-supplements

#cistanche #cistanchetubulosa #cistanchebenefits

Hello, Achiever Fam! 🌟

Today, we’re diving into the world of Cistanche, comparing two fascinating species: Cistanche Deserticola and Tubulosa. Heard about Desert E Cola? Well, it’s not a drink but an intriguing herb! In this video, we’ll explore “Cistanche Deserticola vs Tubulosa.” Let’s unravel the differences and similarities between these two. Don't forget to subscribe for more herbal insights! 🌿🔬 Introducing Our Herbal Fighters: - Cistanche Deserticola: Known as "the ginseng of the desert," traditionally used in Chinese Medicine. 🏜️🌿 - Cistanche Tubulosa: Preferred by the red willow tree, with proven benefits for blood sugar control and more. 🌳🍃 The Battle Begins: - Deserticola: More resistant to cold, higher sugar levels, effective as a laxative. 🥶🌱 - Tubulosa: Known for antidepressant-like effects and abundant growth. 🧠💚 Health Benefits Showdown: - Deserticola: Protects brain and liver health, anti-inflammatory, antioxidant, and anti-ageing properties. 🧠🛡️ - Tubulosa: Aids in blood sugar control, insulin resistance, and has strong antioxidant effects. 🩸🌡️ Which is Better? - No clear winner! Both are used interchangeably with similar renal and intestine health benefits. 🏆🤝 - Different phytochemical compositions: Tubulosa has a higher concentration of echinacosides. 🧪🌿 - Deserticola, while lower in echinacosides, contains 2′-acetylacteoside. 🌱🔍 Availability and Choice: - Tubulosa is more abundant and commonly found in supplements. 💊🌿 - Deserticola and Tubulosa can be chosen based on specific health needs and phytochemical preferences. 🚀🌱 There you have it – the fascinating comparison between Cistanche Deserticola and Tubulosa! Both are excellent choices with unique benefits.

Which one would you pick for yourself? Drop a comment below, and remember to subscribe for more enlightening content from the Super Achievers Club. See you in the next video! 📹👋🌿

[votaryoftheseven]

On The Effects of Prayerblossom on Shadow Afflictions

A note; local sources use the names Prayerblossom and Prayerbloom interchangeably. Both seem to be correct in the Common vernacular of the area.

Other medics have speculated on the effects of Prayerblossom and its interaction with fel, shadow, and even death magic afflicted individuals, often relating the plant to the Holy Light.

While other plants I've seen have consumed arcane from their surrounding areas, I fail to see why Prayerblossom would do the same. There is no natural font or beacon of Light magic noted that I can find in texts surrounding the Swamp of Sorrows, however the area in which Prayerblossom is prevalent is absolutely laden with natural energies.

Sources state nature spirits and pure elementals are very common, and the Green Dragonflight had activity in the area, even if they later fell to corruption. If anything, the plant may simply have incredible curative properties.

Since the supply of plant material I have is limited and my purpose of research narrow, the experiments conducted will be solely focusing on the idea Prayerblossom can aid in the treatment of shadow corruption in some form.

First, I broke down the different parts of the plant into different forms to see if there was a difference in how they could be used or applied. Of the blooms, the stems, the leaves and the roots, I made a tincture and a paste of each of them.

Secondly, I prepared the samples I would be testing on. I had small pieces of meat I had steeped in Shadow, hares I afflicted with Shadow, and soil tainted with Prideful Sha.

Testing each upon each, I recorded the results as follows;

Of the shadow-steeped pieces of meat, the paste of the blooms seemed to have the most potent effect. Applying a little didn't do much, but applying a generous portion, enough to cover the affliction, slowly pushed the corruption to the edges of where I applied the paste. The corruption, when increased by my hand, did not go past where the paste was applied, down to several inches past the surface.

The hares I tested on seemed to mostly want to chew on the stringy paste I had made from the stems, even though they'd been fed plenty prior to testing. Though I did not see a reduction in corruption levels, chewing and even eating the stem paste seemed to make them less nervous and more docile. They did not flee as before when a bright light was shone on them.

Tinctures made from the roots did seem to reduce the hares' corruption levels, though they did not like the medicine, likely due to its dryness and bitterness. The reductions were rather quick, not coming out in the renal process as many other Shadow Protection Potions work, but by shedding it out in the few sweat glands that exist around the mouth. Through careful care, I was able to aid the hares in removing their affliction.

The soil, when mixed with the tincture and even paste from the roots, seemed to slowly, over the course of hours and days, release the sha's taint upon it. Such as is the case of sha, the soil mound smouldered and smoked, though there was no indication of true 'burning'. Adding more root tincture or mixing in more root paste increased the speed of the reaction.

In conclusion; through these few studies, I believe I've worked out a few methods of further treating shadow afflictions.

Paste of the flowers of Prayerblossom seem able of 'chasing out' Shadow corruption. One might be able to use it to line a limb or an area to contain its spread in the body, where extraction can happen in a particular spot. It also may be able to be used to reduce the concentration of shadow corruption if placed on a shadow-infected wound.

While perhaps better as whole stems vs. stem paste, it does seem that the stems have some sort of calming agent in them. While it doesn't affect shadow corruption directly, it may prove useful to those suffering from shadow's mental effects and make patients easier to treat. The tincture did not have the same effect, so it stands to reason there's something in the fibres themselves or in the chewing and mechanical activation that matters.

Prayerblossom root tincture did wonders in general for shadow and void corruption. It not only seems to revitalise, but force the body to excrete the shadow through any means necessary. Applied to non-living material, it severed the bonds between shadow magic and material object given enough contact and time. It may be a useful alternative for those who cannot take SPPs, or a good addition for those already taking an increased dosage of SPP.

Hierei Iatromantis

[yarnyfan]

The Many Benefits of Glutathione: The Powerful Antioxidant That Keeps Your Body in Top Shape

Glutathione, abbreviated as GSH, is a naturally occurring antioxidant in the human body. This potent chemical is critical in preserving our cells from harm and guaranteeing normal cell function. It is created within the body by numerous enzymes and may also be taken through specific foods such as fruits, vegetables, and meats.

One of glutathione's most important properties is its capacity to enhance the immune system. It serves to protect cells from free radicals and decrease oxidative damage. This, in turn, lowers inflammatory levels in the body and protects against cancer. Furthermore, by delaying the aging process, glutathione can assist to keep the skin appearing youthful and healthy.

Glutathione is also beneficial to heart health. It aids in the prevention of heart disease and the promotion of healthy blood flow throughout the body. Furthermore, it promotes kidney function and may lower the risk of renal disease.

Another advantage of glutathione is that it helps to maintain good metabolic function. It can assist regulate metabolism and protect against metabolic illnesses like diabetes. Furthermore, it is important for maintaining healthy brain function and can help avoid cognitive decline.

To summarize, glutathione is a necessary chemical that aids in the healthy functioning of our bodies. It is critical that we obtain enough of it through our diets or supplements. To get the various advantages of glutathione, incorporate glutathione-rich foods in your diet and consider supplementing with a high-quality GSH supplement.

[global-research-report]

Aptamers Market Growth: Key Trends, Opportunities & Forecast

The global aptamers market size is expected to reach USD 10.88 billion by 2030, according to a new report by Grand View Research Inc. The market is expected to expand at a CAGR of 24.54% from 2023 to 2030.  The growth of the market is attributed to the strong presence of product pipelines and their expected launch during the forecast period. Some of the products in the pipeline are E10030 (Fovista), ARC1905 (Zimura) by IVERIC Bio, Inc., AGRO100 by Antisoma Research Ltd, NOX-A12 (olaptesed pegol) & NOX-E36 (emapticap pegol) by NOXXON Pharma, and NU172 by ARCA Biopharma, Inc. AGRO100 completed the phase 1 clinical trial for multiple oncology indications such as non-small cell lung cancer, solid tumors, and renal cancer.

In addition, initiatives undertaken by regulatory agencies such as the U.S. FDA, Health Canada, EMA, COFEPRIS, MHRA, and CDSCO to support the research and development in the field of aptamers are projected to fuel market growth. For instance, in March 2020, IVERIC Bio, Inc. received Fast Track designation from the U.S. FDA for Zimura for the treatment of patients with GA secondary to age-related macular degeneration (AMD). Zimura is a chemically synthesized pegylated RNA aptamer, administered by intravitreal injection. It acts by inhibiting complement factor C5 which is responsible for the development of AMD.

Gather more insights about the market drivers, restrains and growth of the Aptamers Market

Companies are studying aptamers for applications such as western blotting, ELISA, therapeutics, and flow cytometry. Custom aptamer selection is considered to be an important service offered by existing aptamer players to life sciences companies. Thrombin aptamers, cocaine aptamers, and theophylline aptamers are some of the most frequently used customized aptamers for research and development activities. Thus, the surge in numbers of biotech and pharma companies working on research related to aptamers and related technologies has opened up new avenues for the growth of this market.

Moreover, there are a number of strategic initiatives undertaken by key players such as mergers & acquisitions, with an aim to expand their current aptamer product portfolio. For instance, in May 2022, Epicore Biosystems acquired Eccrine Systems' intellectual property and assets. This acquisition boosts Epicore’s wearable microfluidic solutions with additional aptamer-based sweat sensor technology from the Eccrine Systems and the University of Cincinnati to its aptamer product portfolio and strengthens the company’s position in the market. This aptamers-based sensor has been demonstrated in stress, pain, and other healthcare management applications.

Browse through Grand View Research's Biotechnology Industry Research Reports.

The global DNA diagnostics market sizewas estimated at USD 10.61 billion in 2024 and is projected to grow at a CAGR of 8.7% from 2025 to 2030.

The global CRISPR and Cas genes market sizewas estimated at USD 4.69 billion in 2024 and is projected to grow at a CAGR of 16.12% from 2025 to 2030.

Aptamers Market Segmentation

Grand View Research has segmented the global aptamers market on the basis of type, application, and region:

Aptamers Type Outlook (Revenue, USD Million; 2018 - 2030)

Nucleic Acid Aptamer

Peptide Aptamer

Aptamers Application Outlook (Revenue, USD Million; 2018 - 2030)

Diagnostics

Therapeutics

Research & Development

Others

Aptamers Regional Outlook (Revenue, USD Million; 2018 - 2030)

North America

US

Canada

Europe

Germany

UK

France

Italy

Spain

Denmark

Sweden

Norway

Asia Pacific

Japan

China

India

Australia

Thailand

South Korea

Latin America

Brazil

Mexico

Argentina

MEA

South Africa

Saudi Arabia

UAE

Kuwait

Key Companies profiled:

SomaLogic

Aptamer Group

Aptadel Therapeutics

Base Pair Biotechnologies

Noxxon Pharma

Vivonics Inc.

Aptagen, LLC

TriLink Biotechnologies

Altermune LLC

AM Biotechnologies

Order a free sample PDF of the Aptamers Market Intelligence Study, published by Grand View Research.

[uvedanaturals]

A Comprehensive Guide to Natural Kidney Health and Herbal Remedies

Kidneys are essential organs that filter waste and excess fluids from the blood, regulate blood pressure, balance minerals, and produce hormones necessary for red blood cell production and bone health. As vital as they are, kidneys can face challenges due to stress, disease, or age-related decline. Fortunately, natural herbs and supplements can help maintain kidney health and support its functions. This article delves into the best natural kidney health herbs, their benefits, and how they contribute to overall wellness.

Understanding Kidney Function

Healthy kidneys process about 50 quarts of blood every day, removing waste and excess water to create urine. This urine travels through two ureters to the bladder for elimination. Besides filtering blood, kidneys also:

Regulate the balance of minerals like potassium, calcium, and sodium.

Manage blood pressure through hormone release.

Produce erythropoietin, which aids in red blood cell production.

Convert Vitamin D into its active form for bone health.

Given these vital roles, maintaining kidney health is crucial. Proper hydration, a balanced diet, and a healthy lifestyle form the foundation of kidney care. However, herbal remedies can offer additional support, especially as we age or face chronic conditions.

Best Natural Herbs for Kidney Health

Several herbs stand out for their ability to enhance kidney function, prevent complications, and improve overall health. Here are the top options:

1. Vitamin D

Vitamin D is essential for bone health and reducing inflammation. People with kidney disease often struggle to convert Vitamin D into its active form, leading to deficiencies. Supplementing with Vitamin D can help mitigate cardiovascular risks and support bone health.

Recommended Dosage: 800–2,000 IU daily, based on individual needs.

2. Codiya Nephroshield Mac

Designed for people with diabetes and elevated creatinine levels, Codiya Nephroshield Mac protects the kidneys, supports liver function, and prevents renal failure. Its herbal blend promotes natural cleansing and reduces toxic accumulation.

Recommended Dosage: One tablet twice daily with water.

3. Iron

Iron supplements address anemia, a common issue in chronic kidney disease (CKD). Iron helps in the production of hemoglobin, enabling oxygen transport throughout the body.

Recommended Dosage: 100–200 mg daily for those with deficiency (consult a physician).

4. Uveda Nephro Panchamrit

This traditional herbal formula focuses on kidney cleansing and inflammation reduction. Its enhanced version, Nephro Panchamrit Plus, offers additional detoxification benefits, supporting kidney stone prevention and urinary tract health.

Recommended Dosage: 10 cc from each bottle, three times daily.

5. Uveda Naturals 5-in-1 Combo

This Ayurvedic blend supports detoxification, kidney function, blood pressure control, and overall health. It’s ideal for individuals seeking a comprehensive approach to renal care.

6. Vitamin B12

Vitamin B12 helps maintain healthy red blood cells and regulates phosphorus levels, essential for kidney function. While it doesn’t replace medical treatments like dialysis, it aids in restoring balance in the body.

Herbs for Kidney and Bladder Health

Certain herbs and plants can enhance kidney and bladder health, offering protection against infections and promoting detoxification. Key herbs include:

1. Cranberry

Cranberries prevent urinary tract infections (UTIs) by inhibiting bacterial growth in the bladder.

2. Parsley

Known for its mild diuretic properties, parsley helps flush out toxins and reduce inflammation.

3. Marshmallow Root

This herb soothes urinary tract inflammation and relieves bladder irritation.

4. Goldenrod

With its diuretic properties, goldenrod reduces swelling and inflammation.

5. Uva Ursi

This herb has antiseptic and astringent properties, making it effective against UTIs and inflammation.

6. Dandelion Root

A natural diuretic, dandelion root promotes kidney function and helps manage water retention.

7. Juniper Berries

Juniper berries aid in flushing out toxins and supporting kidney health.

Best Drinks for Kidney Health

Hydration is key to maintaining kidney function. Certain beverages can enhance detoxification and protect against kidney-related issues:

Cranberry Juice: Prevents UTIs.

Carrot Juice and Beet Juice: Rich in antioxidants, these juices promote detoxification.

Herbal Teas: Such as dandelion or nettle tea, which support kidney function.

Dissolving Kidney Stones Naturally

Kidney stones are painful but can often be managed naturally. Lemon juice and apple cider vinegar are believed to help dissolve kidney stones, making them easier to pass. Staying hydrated is critical to preventing stone formation and aiding their removal.

Herbs to Avoid for Kidney Health

While many herbs support kidney health, some can be harmful, particularly for individuals with CKD. Avoid excessive consumption of:

Fat-Soluble Vitamins (A, E, K): These can accumulate and cause toxicity.

Potassium-Rich Herbs: Such as certain pre-workout supplements, which may pose risks for those with kidney failure.

Always consult a healthcare provider before starting any new herbal or vitamin regimen, especially if you have an existing kidney condition.

Why Choose Uveda Naturals?

Uveda Naturals specializes in Ayurvedic remedies tailored to kidney health. Their products, like Nephro Panchamrit and 5-in-1 Combo, are designed to enhance kidney function, dissolve stones, and promote overall wellness. With a focus on natural cleansing and detoxification, Uveda Naturals provides a comprehensive solution for those seeking herbal support for their kidneys.

Conclusion

Kidneys are vital to overall health, and incorporating natural herbs into your routine can provide significant benefits. From Vitamin D and Iron to herbal blends like Uveda Nephro Panchamrit, these remedies can support kidney function, prevent complications, and promote detoxification. Always consult a healthcare provider to determine the best approach for your individual needs. For a range of effective, natural products, consider Uveda Naturals as a trusted source for kidney health.

FAQs on Natural Kidney Health Herbs

1. Which are the best natural kidney herbs? Codiya Nephroshield Mac, Uveda Nephro Panchamrit, Vitamin D, Iron, and Vitamin B12 are among the top choices.

2. What is the best drink for kidney health? Cranberry juice, carrot juice, beet juice, and herbal teas are excellent options.

3. What dissolves kidney stones quickly? Lemon juice and apple cider vinegar can help dissolve kidney stones, while proper hydration aids in passing them.

4. Can garlic reduce creatinine levels? Yes, garlic helps protect kidneys from free radical damage and may aid in lowering elevated creatinine levels.

5. Why choose Uveda Naturals for kidney health? Uveda Naturals offers Ayurvedic remedies tailored to kidney health, including products for kidney function support, stone prevention, and detoxification.

[unleashwellness]

Best Supplements to Stop Dog Shedding: Fur-getful No More!

Are you worried about your pet’s kidney health and on the lookout for the best natural supplements for dogs with kidney problems? Don’t stress—Unleash Wellness is here to help! Supporting your furry friend’s kidney health can feel overwhelming, but with the right knowledge and natural supplements, you can improve your pet’s overall well-being.

Understanding Kidney Issues in Dogs: The Sneaky Symptoms

Kidney problems in dogs can be tricky to detect, but early diagnosis is critical for effective treatment. Here are some common symptoms to watch out for:

Increased Thirst and Urination: If your dog suddenly starts drinking a lot more water and needing frequent bathroom breaks, it may be a sign of kidney dysfunction. Keep an eye out for changes in the color or smell of urine as well.

Loss of Appetite and Weight Loss: If your dog isn’t eating well, even turning down their favorite meals, it might signal a deeper health issue. Unexplained weight loss can also be a red flag.

Lethargy: A normally playful dog that’s become sluggish and spends more time napping than running around may be experiencing kidney trouble.

Vomiting and Diarrhea: Frequent vomiting or diarrhea can point to kidney issues, especially if these symptoms persist over time.

Bad Breath or Mouth Ulcers: If your dog has unusually bad breath or if you notice ulcers in their mouth, this could indicate an imbalance in the body, which might be linked to kidney problems.

If you notice any of these signs, it’s important to consult a vet. Early detection and proper treatment can help prevent further complications.

Best Natural Supplements for Dogs with Kidney Problems: Nature’s Cure

For many pet owners, natural remedies are a preferred choice when it comes to managing kidney issues. The best natural supplements for dogs with kidney problems not only support renal health but also aid in improving overall wellness. Let’s take a look at some of the top natural supplements you can consider:

1. Omega-3 Fatty Acids

Omega-3 fatty acids are excellent for reducing inflammation in your dog’s kidneys. These healthy fats help slow down the progression of kidney disease and improve your pet's overall health.

2. Probiotics

A healthy gut is essential for kidney health. Probiotics support your dog's digestive system by maintaining the right balance of good bacteria. This, in turn, helps the kidneys function better by aiding in detoxification processes.

3. Vitamin B Complex

B vitamins are crucial for dogs with kidney issues, as they help combat fatigue and support energy production. When kidney function is compromised, these vitamins can be lost through increased urination, so replenishing them is vital.

At Unleash Wellness, we have crafted supplements that combine these beneficial ingredients to support your dog’s kidney health. We offer high-quality, natural supplements that can make a real difference in your dog’s well-being.

ELIVIR®: A Powerhouse for Kidney Health

Unleash Wellness offers ELIVIR®, a natural supplement specially formulated to support both liver and kidney health. Packed with a blend of herbs, vitamins, and other natural ingredients, ELIVIR® helps detoxify the body, reduce inflammation, and promote overall kidney function.

Here’s what sets ELIVIR® apart:

Amla: A rich source of Vitamin C, Amla supports the immune system and acts as a powerful antioxidant.

Ashwagandha: This adaptogenic herb helps reduce stress and supports the body’s natural healing processes.

Mulethi (Licorice): Known for its anti-inflammatory properties, it soothes the digestive system and supports kidney function.

Giloy: Renowned for its detoxifying properties, Giloy helps cleanse the blood, aiding kidney health.

Sonth (Ginger): With anti-inflammatory effects, ginger supports digestion and kidney function.

By choosing ELIVIR®, you’re giving your pet the best natural care for their kidney health, helping them stay active and happy for years to come.

VITAM PAWS®: A Nutritional Boost

In addition to ELIVIR®, Unleash Wellness offers VITAM PAWS®, a multivitamin that helps fill nutritional gaps in your pet’s diet. VITAM PAWS® includes vitamins A, E, and selenium, which are vital for combating oxidative stress—a common problem for dogs with kidney issues.

This supplement ensures your dog is getting all the essential nutrients they need to maintain overall health, further supporting their kidneys and other organs.

FAQs on Kidney Health and Supplements

Q: Can ELIVIR® cure kidney disease?A: ELIVIR® is not a cure, but it is designed to support kidney health and overall well-being. Always consult your vet for a proper diagnosis and treatment plan for serious conditions.

Q: How long before I see results with ELIVIR®?A: While some dogs may show improvements within 4-6 weeks, it’s recommended to give the supplement at least 2-3 months for optimal results.

Q: Are these supplements safe for all dogs?A: ELIVIR® and VITAM PAWS® are formulated with natural ingredients and are safe for most dogs. However, always check with your vet before introducing any new supplement into your dog’s routine, especially if they have pre-existing health conditions.

Q: Can I give ELIVIR® and VITAM PAWS® together?A: Yes! ELIVIR® and VITAM PAWS® work together to support kidney and overall health. However, consult with your veterinarian to ensure there are no interactions with other medications.

Conclusion

Taking care of your dog’s kidney health requires attention and care, but the right supplements can make a significant difference. With Unleash Wellness products like ELIVIR® and VITAM PAWS®, you can give your furry friend the best natural support for their kidney health. So, if you’re on the lookout for the best natural supplements for dogs with kidney problems, be sure to consider these options and consult with your vet for a personalized plan. Your dog deserves the best, and Unleash Wellness is here to help you provide that!

[aegislifescience]

Redefining Post-Hemodialysis Bleeding Control with SURGISPON® DIAL

Chronic kidney disease (CKD) is a significant global health issue, affecting over 750 million people worldwide. For more than two million patients with end-stage renal disease (ESRD), hemodialysis serves as a vital lifeline, enabling survival despite the loss of kidney function [1, 2]. As the need for hemodialysis in patients with end-stage renal disease (ESRD) continues to rise, the creation of hemodialysis access points—such as arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs)—has become a routine yet essential vascular surgery procedure, crucial for ensuring long-term dialysis success [3, 4].

Maintaining the patency of these dialysis access points is a significant challenge, as less than half of all AVFs and AVGs remain functional beyond three years due to frequent complications such as narrowing or thrombosis [4]. To address these issues, catheter-based interventions like percutaneous transluminal angioplasty are commonly used to restore blood flow. However, achieving hemostasis after these procedures remains a time-consuming challenge, underscoring the need for better bleeding control methods.

The presence of uremic toxins in ESRD patients complicates bleeding control, underscoring the need for improved hemostatic solutions. This is where haemostats for dialysis like SURGISPON® DIAL can revolutionize patient care.

Understanding the Need for Dialysis

Dialysis becomes necessary when kidney function declines to a point where 85-90% of it is lost, marked by a glomerular filtration rate (GFR) of less than 15. In this stage, without dialysis, toxins accumulate in the body, leading to serious health risks. Despite its life-saving properties, dialysis presents challenges, among the most pressing being the management of post-procedure bleeding.

The Challenge of Post-Hemodialysis Bleeding

After each hemodialysis session, controlling bleeding at the puncture site is a critical concern. Although this may seem straightforward, several factors complicate the process—most notably the use of anticoagulants, such as heparin, which are essential for preventing blood clotting during dialysis. However, these same medications significantly increase the risk of post-dialysis bleeding [5]. This complication, known as Post-Hemodialysis Site Hemorrhage (PHSH), becomes even more complex in patients with other conditions like hypertension, diabetes, or low platelet counts. These factors prolong the bleeding and make the hemostasis process time-consuming and difficult.

Methods for Controlling Post-Dialysis Bleeding

Today, healthcare professionals use two primary techniques to control post-hemodialysis bleeding:

Direct Pressure: This is the most commonly used method. It involves applying firm pressure to the puncture site with gauze or a cotton roll until the bleeding stops. The time required can vary greatly, from 20-30 minutes to over an hour, depending on the patient’s health status, comorbidities, and the extent of the bleeding.

Tourniquet Application: a sterile elastic tourniquet is applied along with direct pressure to control bleeding. While effective, applying excessive pressure can reduce the lifespan of the fistula, the vascular access point used for dialysis. This renders it a suboptimal solution for long-term use, particularly in patients requiring frequent dialysis. 

The Need for Advanced Haemostats for dialysis

The current methods, while standard, have limitations. They take time, are labour-intensive, and may damage the vascular access, potentially compromising future dialysis sessions [6]. This highlights the need for advanced hemostats for dialysis, like SURGISPON® DIAL, that can offer rapid, reliable bleeding control without compromising the integrity of the fistula or graft. These advanced solutions would not only reduce the time required for post-dialysis care but also decrease the burden on healthcare staff, allowing them to focus on other critical aspects of patient care. Discover more about our hemostatic solutions here.

We at Aegis Lifesciences introduce “SURGISPON®DIAL”, an optimal haemostatic dialysis bandage to control bleeding post-renal dialysis.

The Role of SURGISPON® DIAL in Post-Hemodialysis Bleeding Control 

As the need for hemodialysis continues to grow, the challenge of maintaining the functionality of dialysis access points persists, with frequent complications such as narrowing and thrombosis[3]. Despite advancements like catheter-based interventions, post-procedure bleeding remains a significant and unresolved issue, highlighting the need for improved hemostatic solutions like SURGISPON® DIAL.

SURGISPON® DIAL offers a revolutionary approach to managing post-dialysis bleeding, addressing the unique challenges posed by anticoagulants and other complicating factors, thus redefining post-hemodialysis bleeding control and enhancing patient care.

SURGISPON® DIAL

SURGISPON® DIAL is an absorbable hemostatic gelatin sponge specifically designed to meet the unique challenges of post-renal dialysis patients. By addressing the limitations of traditional hemostatic methods, SURGISPON® DIAL offers a faster, more efficient solution.

a) Key benefits

Highly Porous Structure: SURGISPON® DIAL is capable of absorbing fluids 40–50 times its own weight, ensuring rapid and effective bleeding control.

Function: SURGISPON® DIAL provides a matrix that promotes platelet aggregation and coagulation and prevents the loss of natural clotting factors.

Indication: It is specifically designed for use in post-hemodialysis patients to stop bleeding at the puncture site.

Mode of Action: SURGISPON® DIAL’s porous structure activates the thrombocytes at the moment blood comes in contact with the matrix of the sponge. This initiates the release of substances that promote thrombocyte aggregation while their surfaces undergo change, facilitating fibrin formation and arresting the bleeding.

Size available: offered in a convenient 30cm x 30cm x 10cm size, it is specifically designed to cover dialysis puncture sites.

Reduced Recovery Time: SURGISPON® DIAL is designed to minimize post-operative time and promote a faster return to normal activities, enhancing recovery outcomes for patients. 

b) Clinical highlight 

Cristóbal et al. (2021) aimed to evaluate the pressure generated by an adjustable hemostasis clamp on arteriovenous fistulas (AVFs) during the hemostasis process and compare it with the direct two-finger pressure applied by the patient. The study analyzed data from 51 hemodialysis procedures involving 15 patients. SURGISPON® DIAL, an absorbable gelatin dressing, was utilized as an adjunct hemostatic agent during the study to apply pressure to the puncture site, enhancing the effectiveness of both the adjustable clamp and manual compression techniques. The combination of SURGISPON® DIAL with these pressure methods contributed to improved hemostasis, ensuring adequate pressure while minimizing the risk of complications, such as external bleeding or hematomas [7]. Read the full case study here.

Conclusion

Managing post-dialysis bleeding is a vital but often underemphasized part of patient care. With the increasing number of patients requiring dialysis, the need for more effective and efficient hemostatic solutions is clear. SURGISPON® DIAL addresses this challenge by providing a fast, reliable method to control bleeding while preserving vascular access for future treatments. Its innovative design reduces recovery time, enhances patient outcomes, and lightens the workload for healthcare professionals. By integrating SURGISPON® DIAL into their practices, healthcare providers can significantly improve the quality of post-dialysis care. Discover our full range of hemostasis solutions here.

[credenceresearchdotblog]

The Vascular Grafts Market is projected to grow from USD 1,263.48 million in 2023 to an estimated USD 2,422.39 million by 2032, with a compound annual growth rate (CAGR) of 7.50% from 2024 to 2032. The global vascular grafts market has seen significant growth in recent years, driven by the increasing prevalence of cardiovascular diseases, the aging population, and advancements in medical technology. Vascular grafts are used in surgical procedures to bypass, repair, or replace damaged blood vessels, making them a crucial component in the treatment of various vascular conditions. These grafts can be synthetic, biological, or composite, depending on the material used, and they play a critical role in procedures such as coronary artery bypass surgery, peripheral artery disease treatment, and hemodialysis access.

Browse the full report at https://www.credenceresearch.com/report/vascular-grafts-market

Market Overview

As of 2024, the vascular grafts market is experiencing a robust growth trajectory, with a market value that is expected to reach billions of dollars in the coming years. The demand for vascular grafts is fueled by the increasing burden of cardiovascular diseases, which are among the leading causes of death globally. According to the World Health Organization (WHO), cardiovascular diseases (CVDs) claim over 17 million lives annually, and this number is expected to rise due to factors such as unhealthy lifestyles, rising obesity rates, and an aging population.

The market is segmented based on product type, application, and end-user. The main types of vascular grafts include:

1. Endovascular Stent Grafts – Used in minimally invasive procedures to treat aneurysms or occluded blood vessels. 2. Peripheral Vascular Grafts – Typically used to bypass or replace damaged vessels in the peripheral arterial system. 3. Hemodialysis Access Grafts – Commonly used to create arteriovenous (AV) fistulas for patients undergoing dialysis.

Key Drivers of Market Growth

1. Rising Prevalence of Cardiovascular Diseases The increasing incidence of cardiovascular diseases, including coronary artery disease and peripheral artery disease, is the primary driver of the vascular grafts market. As lifestyles become more sedentary, coupled with poor dietary habits and rising levels of obesity, the demand for cardiovascular procedures such as coronary artery bypass grafting (CABG) is rising.

2. Aging Population The global population is aging, and older adults are more prone to cardiovascular diseases, atherosclerosis, and related complications. This demographic trend is a major factor contributing to the growth of the vascular grafts market. Elderly individuals often require vascular grafts in procedures such as aneurysm repair or dialysis access creation, which boosts demand.

3. Technological Advancements The development of new materials and technologies for vascular grafts has significantly enhanced their performance and outcomes. For instance, the introduction of bioengineered grafts and hybrid materials that combine synthetic and biological properties has improved the compatibility and durability of grafts. Furthermore, advancements in endovascular procedures, which are less invasive than traditional open surgeries, have driven the adoption of vascular grafts, particularly stent grafts.

4. Increasing Incidence of End-Stage Renal Disease (ESRD) The rising prevalence of diabetes and hypertension has contributed to a growing number of patients with end-stage renal disease (ESRD). These patients require hemodialysis, and vascular grafts are often used to create AV fistulas for dialysis access. As the incidence of ESRD increases, so does the demand for vascular grafts, particularly in the healthcare sector of developed countries.

Challenges Facing the Market

Despite the promising growth, the vascular grafts market faces several challenges. One major concern is the risk of graft failure due to infection, thrombosis, or rejection. While advances in material science have improved the performance of grafts, complications still arise, particularly in high-risk patients. Additionally, the cost of vascular grafts and associated procedures can be prohibitive for patients in low- and middle-income countries, limiting access to these life-saving interventions.

Another challenge is the stringent regulatory environment that governs the approval and commercialization of vascular grafts. Medical devices, especially those used in critical procedures, are subject to rigorous testing and approval processes. This can delay the introduction of new products to the market.

Regional Insights

The vascular grafts market is segmented by region, with North America, Europe, Asia-Pacific, and the Rest of the World (RoW) being key markets. North America holds the largest share of the market, driven by the high prevalence of cardiovascular diseases, a well-established healthcare system, and the presence of leading medical device manufacturers. Europe follows closely behind, with a similar disease burden and strong healthcare infrastructure.

In contrast, the Asia-Pacific region is expected to witness the fastest growth in the coming years, driven by the increasing healthcare expenditure, a growing middle class, and rising awareness of cardiovascular health. Countries such as China and India are seeing a surge in demand for vascular grafts due to the rising incidence of lifestyle-related diseases and improvements in healthcare accessibility.

Future Outlook

The future of the vascular grafts market looks promising, with continued growth expected due to ongoing advancements in medical technology, an aging population, and the increasing prevalence of cardiovascular diseases. Innovations in graft materials, such as the use of bioresorbable polymers and tissue-engineered grafts, will likely enhance the durability and success rates of vascular procedures.

Moreover, as healthcare systems in emerging economies improve, the demand for vascular grafts in these regions is expected to increase. Government initiatives aimed at improving cardiovascular health and expanding access to healthcare services will also play a crucial role in driving market growth.

Key players

Medtronic

Terumo Corporation

LeMaitre Vascular, Inc.

Getinge AB

BD (Becton Dickinson)

Abbott

Braun Melsungen AG

L. Gore and Associates, Inc.

MicroPort Scientific Corporation

Endologix

Segments

Based on product

Haemodialysis Access Grafts

Endovascular Stent Grafts

Coronary Artery Based on-Pass Grafts

Vascular Grafts for Aorta Disease

Peripheral Vascular Grafts

Based on application

Cardiac Aneurysm

Endovascular Stent Graft

Vascular Graft

Kidney Failure

Vascular Occlusion

Coronary Artery Disease

Others

Based on raw material

Synthetic Vascular Grafts

Polytetrafluoroethylene (PTFE) Grafts

Polyester Grafts,

Polyurethane Grafts

Biological Vascular Grafts

Autografts

Allografts

Xenografts

Hybrid Vascular Grafts

Based on region

North America

U.S.

Canada

Mexico

Europe

Germany

France

U.K.

Italy

Spain

Rest of Europe

Asia Pacific

China

Japan

India

South Korea

South-east Asia

Rest of Asia Pacific

Latin America

Brazil

Argentina

Rest of Latin America

Middle East & Africa

GCC Countries

South Africa

Rest of the Middle East and Africa

Browse the full report at https://www.credenceresearch.com/report/vascular-grafts-market

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Contact:

Credence Research

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[celeste-vibri]

publishing for momentum

i am praying this small prayer for a boost in momentum.

as i type, i gain some typing and focus momentum. i took a thc gummy and drank organic instant coffee so i feel like a battle of neurotransmitters going on in my chest. adrenergic response simultaneous to an overthinking mind.

dopamine novelty, improved renal flow, inotropic properties. i am so stupid i am such trash. the more i talk down on myself, the more i allow myself to use it as an excuse to avoid accountability. i am too rash in decision making. i am careless to the feelings of others. i am overconfident and a bad communicator.

the laughter at the beginning of 'more elbow' by rei harakami. two kids!! do you know how wild that is. maybe i have grown some, but not enough! i journaled every day for over three years just to feel something.

it's so stupid of me! i can take accountability and still drown myself in thc gummies and feel so dumb and forget and pretend that something i did never happened. i feel both like victim and perpetrator, i hide from my actions. even me being aware and calling out my stupidities doesn't help me any. i don't grow from being aware, i grow from the bravery and courage in the moment to choose the OTHER action.

nothing i do is good enough for you, but because i know. it's not. i have not grown enough to your instruction. not only am i not close enough to your Word, i have not appreciated your Word enough to have read closely and realized the profundity of what you have and had to say. i have to get to the fond of what you are communicating.

plum village. twin towers.

was it just my face and my voice that gave you the impression that i was worth saving or teaching? i really have very little going for me. she is taking a nap. they are both taking a nap. what are the odds?

i think it's so funny when my mother, my lover, my sister, and my teacher are all having a period at the same time. the lunar eclipse is coming up for us.

this line by ocean vuong, "if you see me, then i prayed correctly."

[hongkongdengyue]

Rinboq

[Drug name] Generic name: Upadacitinib Sustained Tablets

Trade name: Ruifu

English name: Upadacitinib Sustained

[Ingredients] The main ingredient of this product is upadacitinib.

[Properties] This product is a purple (15mg specification) or red (30mg specification) oval biconvex film-coated tablet. After removing the coating, it is white to off-white to light yellow to gray-brown to light brown, and spots may appear.

[Indications] This product is suitable for adults and adolescents aged 12 years and above with refractory, moderate to severe atopic dermatitis who have poor response to other systemic treatments (such as hormones or biological agents) or are not suitable for the above treatments.

[Dosage and Administration] Treatment with upadacitinib should be initiated by and used under the guidance of a physician who has experience in the diagnosis and treatment of this product's indications. Dosage The starting dose for children aged 12 years and older and weighing ≥ 40 kg and adults up to 65 years of age is 15 mg once daily. If the response is poor, consider increasing the dose to 30 mg once daily. If the 30 mg dose does not achieve an adequate response, discontinue this product. The lowest effective dose required should be used to maintain the response. The safety and efficacy of this product has not been studied in adolescents weighing less than 40 kg. The recommended dose for adults aged 65 years and older is 15 mg once daily. Data for patients aged ≥ 75 years are limited. Recommended dose for patients with renal impairment or severe hepatic impairment Renal impairment Patients with mild or moderate renal impairment do not require dose adjustment. There are limited data on the use of upadacitinib in patients with severe renal impairment (see [Pharmacokinetics]). Upadacitinib 15 mg once daily should be used with caution in patients with severe renal impairment. Upadacitinib 30 mg once daily is not recommended in patients with severe renal impairment. Upadacitinib has not been studied in subjects with end-stage renal disease. No dose adjustment is required for patients with mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment (see [Pharmacokinetics]). This product should not be used in patients with severe hepatic impairment (Child-Pugh C) (see [Contraindications]). Usage This product can be taken with or without food and at any time of the day. This product should be swallowed whole and should not be broken, crushed or chewed to ensure that the full dose is administered. Combined topical treatment This product can be initiated with or without topical corticosteroids It is not recommended to start treatment with this product in patients with an absolute lymphocyte count (ALC) less than 500 cells/mm3, an absolute neutrophil count (ANC) less than 1000 cells/mm3, or a hemoglobin level less than 8 g/dL. (See [Precautions] and [Adverse Reactions]). Suspension of administration If a patient develops a serious infection, treatment with this drug should be suspended until the infection is under control.

[priteshwemarketresearch]

Ipilimumab Market by Platform, Type, Technology and End User Industry Statistics, Scope, Demand with Forecast 2034

Global Ipilimumab Market: A Growing Force in Cancer Immunotherapy

Ipilimumab Market under the brand name Yervoy, is a monoclonal antibody used in the treatment of various types of cancer. It works by blocking programmed cell death protein 1 (PD-1), a protein that helps cancer cells evade the immune system. Ipilimumab is often used in combination with other treatments, such as chemotherapy or other immune checkpoint inhibitors.

Request Free Sample PDF:https://wemarketresearch.com/reports/request-free-sample-pdf/lpilimumab-market/1500

Market Dynamics:

The global ipilimumab market is driven by several factors:

Increasing Prevalence of Cancers: The rising incidence of cancers worldwide, particularly melanoma, is a key driver of market growth.

Drug Efficacy: Ipilimumab has demonstrated significant efficacy in clinical trials, leading to increased adoption in treatment regimens.

Expanding Indications: Ongoing research is exploring the potential of ipilimumab for treating other cancer types, such as renal cell carcinoma and non-small cell lung cancer.

Competitive Landscape: While ipilimumab faces competition from other immune checkpoint inhibitors, its unique properties and clinical data have contributed to its market success.

Market Segmentation

The ipilimumab market can be segmented based on:

Cancer Type: Melanoma, renal cell carcinoma, non-small cell lung cancer, and other indications.

Treatment Stage: First-line, second-line, and third-line treatments.

Geography: North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa.

Market Challenges and Opportunities

High Drug Cost: The price of ipilimumab can be a significant barrier for patients and healthcare systems.

Reimbursement Challenges: Gaining insurance coverage for ipilimumab can be complex in some regions.

Emerging Competitors: The development of new immune checkpoint inhibitors and targeted therapies poses competition to ipilimumab.

Expanding Indications: The potential for ipilimumab to be approved for additional cancer types represents a significant growth opportunity.

Opportunities in the Ipilimumab Market

Expanding Indications: Ongoing research into new cancer indications provides ample opportunities for market expansion. Trials exploring the efficacy of ipilimumab in cancers like prostate cancer and other solid tumors could lead to new approvals and increased market potential.

Patient Access and Affordability: Efforts to improve patient access and reduce treatment costs could open new avenues for market growth. Innovations in pricing models, patient assistance programs, and insurance coverage can make ipilimumab more accessible to a broader patient population.

Biomarker Development: The development of biomarkers to identify patients who are most likely to benefit from ipilimumab treatment could enhance its clinical use and market adoption. Personalized medicine approaches can optimize treatment regimens and improve patient

Challenges Facing the Market

High Cost of Treatment: Ipilimumab, like many immunotherapies, is associated with a high cost. This can limit its accessibility and impact overall market growth. Addressing cost-related challenges and finding ways to make treatments more affordable is crucial.

Competitive Landscape: The immuno-oncology field is highly competitive, with numerous companies developing similar checkpoint inhibitors and combination therapies. Staying ahead in terms of innovation and clinical efficacy is essential for maintaining market position.

Adverse Effects and Tolerability: Managing the side effects of ipilimumab, which can include immune-related adverse events, remains a challenge. Ensuring that patients can tolerate the treatment while effectively managing these side effects is vital for sustained market success.

Competitive Strategies and Market Positioning

Strategic Partnerships: Collaborations between pharmaceutical companies, research institutions, and oncology centers are pivotal in advancing ipilimumab’s market reach. Strategic partnerships can lead to joint research efforts, shared resources, and enhanced market access.

Innovation and Differentiation: In a competitive Ipilimumab Market, differentiating ipilimumab from other immune checkpoint inhibitors is essential. Innovations such as novel drug formulations, improved delivery methods, or adjunctive therapies can enhance its appeal. Companies are also investing in next-generation immunotherapies to maintain a competitive edge.

Marketing and Education: Effective marketing strategies and educational initiatives play a key role in promoting ipilimumab. Awareness campaigns aimed at both healthcare professionals and patients can drive informed decision-making and increase adoption rates. Educational programs about the benefits, side effects, and management of ipilimumab are crucial for its successful integration into clinical practice.

Research and Clinical Advancements

Innovative Research: Cutting-edge research into the mechanisms of action of ipilimumab and its interactions with the immune system is advancing our understanding of its therapeutic potential. Research into biomarkers that predict response and resistance to ipilimumab can lead to more personalized treatment approaches and improved outcomes.

Combination Therapies: Ongoing clinical trials are exploring combinations of ipilimumab with other therapies, such as chemotherapy, radiotherapy, and targeted agents. These studies aim to enhance efficacy, reduce resistance, and improve patient outcomes. Positive results from these trials could expand the indications and Ipilimumab Market potential of ipilimumab.

Real-World Evidence: Collecting real-world evidence (RWE) is increasingly important in demonstrating the effectiveness of ipilimumab outside controlled clinical settings. RWE can provide insights into long-term outcomes, safety profiles, and patient experiences, supporting broader adoption and informed decision-making.

Future Outlook

The global ipilimumab market is expected to continue growing, driven by advancements in cancer research, expanding indications, and increased patient access. As the drug's efficacy is further established and reimbursement challenges are addressed, the market is poised for significant expansion.

The ipilimumab market is poised for continued growth, driven by advancements in cancer research, combination therapies, and expanding indications. While challenges such as cost and competition exist, the opportunities for innovation and patient access offer promising prospects. As the landscape of cancer treatment evolves, ipilimumab is likely to remain a key player in the immunotherapy arena, contributing to the ongoing quest for more effective and personalized cancer treatments.

Conclusion:

The ipilimumab market stands at a crossroads of significant potential and ongoing challenges. As a cornerstone of immuno-oncology, ipilimumab has already demonstrated its transformative impact on cancer treatment. However, its journey is far from complete, and the path forward involves navigating a landscape shaped by rapid advancements, regulatory complexities, and evolving patient needs.