#regulatory T cell

[strawberoni]

older CaW art I forgot to post… (around 3 months ago 😭)

[scopnotes]

Dale is a Helper T cell who suffers from a lot of frustration and self-hatred.

He despises knowing he’s an ‘imperfect’ (labeled ‘defective’) white blood cell but what’s even worse to him is being surrounded by them (Tars, Phal, Fleur, etc).

He spent his whole life masking his struggles alone while his squad never really needed to do that. He ends up getting pretty rough with Tars to the point where a fight occurs between the two.

Fortunately, she, and the group, will help Dale on opening up about his feelings.

And here is Amig!

A Regulatory T cell who becomes Dale’s assistant and emotional support in his job. They’re basically very chill and kind to everyone.

[macrophage-nursery]

Human AU names for the cells :

U1146 : Shirogane

U-4989 : Yashiro

U-2626 : Toshiro

U2048 : Kenshiro

U2001 : Mashiro

AE3803 : Akari

AA5100 : Akane

Killer T : Kenta

NK cell : Nikki

Macrophage : Maria

Helper T : Hiroto

Regulatory T : Reina (the name with R and T in the middle didn't please me so I half assed it haha)

B cell : Banri

Platelet : Hinako (it was hard to find anything cute with a P so I gave up and found a cute name instead)

Eosinophil : Koizumi (name starting with ko because : Kōsankyū

Basophil : Kohei (another name starting by ko because : Kōenkikyū)

Mast cell : Masumi (because Masuto saibou)

Dendritic cell : Juichi (because Jujo saibou)

Basic cell/Cell boy : Nobu

Cancer cell : Haneki (referring to the moment he had wings)

It's pure amateurish. Do you have your own version? If so, I'd be glad to see it!

[ieatcerealboxes]

U-1146: what the fuck why are you helping out cancer cell

Regulatory t cell: that's oomf😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭😭

[neuthanasia]

hgkeveeh

Regulatory/Suppressor T cell

Raymond

Male

April 14 1989

210 cm

O+

[laqueus]

I got my ears pierced yesterday!

[tzifron]

Here, I will give you, the reader, clear enumerations where SARS Cov 2 is unlike a common cold.

SARS Cov 2 triggers a unique, long-lived inflammatory overreaction unseen in Sepsis and influenza.

SARS Cov 2 sends T cells into the brain while lethal influenza does not.

SARS Cov 2 directly causes autoimmunity by reprogramming a special type of T cell called the T regulatory cell, which has never been observed before.

The human genetic line has not propagated any sarbecovirus elements therefore never has faced Sarbecovirus infection to the extent to evolutionarily adapt, except in the unlikely theoretical possibility of extremely negative selection (meaning infected humans did not create progeny.)

There are more exceptional facets but these are simple and digestible. There is also more to write about but I must make a confession. The status quo has morphed in such a way as to browbeat scientists into disavowing a harsh reality in order to acquiesce to corporate and business interests. As we see the average life expectancy decline, we have been left intellectually out in the cold. The truth tellers have been assaulted and crushed, and the individuals that comprise the public, in denial, will put off the realization of a below 70s life expectancy until each one approaches retirement in piecemeal, just as all the grains of sand in an hourglass do not fall at once.

[darkmaga-returns]

The jabbed are experiencing an explosive rate of aggressive new cancers, and HERE is how it's happening:

Joy Lucette Garner

Oct 30, 2024

Stephanie Seneff, an MIT S. Research Scientist, has published a peer-reviewed, authoritative, and crystal clear scientific paper (HERE) laying out the exact mechanisms by which the jabs are in fact causing a massive explosion of extremely aggressive cancers, (and plenty of other deadly diseases) of a type never seen before, leaving doctors (purportedly) “baffled” by how incredibly deadly they are, such that by the time it’s even diagnosed, patients are already in the “final” stages.

It’s an extremely technical paper, but here are the scientific facts:

HIGHLIGHTS:

• A plethora of autoimmune disease incidences occurred after COVID-19 mRNA injections were rolled out.

• Aggressive cancer cases have occurred in the bodies of recipients at sites where the mRNA was injected and at distant metastatic sites.

• The mRNA vaccines cause thymic involution (shrinking) and dysregulation of the T regulatory (Treg) and T effector (Teff) homeostatic cell balance.

• Activated immune cells deliver spike protein to the thymic epithelial cells, damaging them.

• The Treg/Teff balance may determine the fate of autoimmunity and/or cancer and is different for patients with cancer versus those without any cancerous tissues.

• Repeated mRNA injections lead to empirical evidence of impaired immune functions(elevated IgG4, PD-L1), associated with increased autoimmunity and cancer risks, and decreased resistance to infections.

• In the with-cancer recipients, the mRNA vaccine may be associated with either autoimmunity or further progression of the cancer(s) depending on the immunotherapy treatment the patient receives. (PDF) Autoimmune and Neoplastic Outcomes After the mRNA Vaccination: The Role of T Regulatory Cell Responses.

[strawberoni]

(repost, sorry ahaha)

regulatory t and nk (≧∀≦)

me pairing the baddest btches together because it just makes sense yk… but in all honesty i love them both and their interactions have so much potential I LOVE THE BOTH OF THEM SM… i would make more art of them if i wasn’t shy

CELL YURI 4 LIFE >:3

[krystal-prisms]

What happens when you immune system goes Hey Fuck You Actually

Describe your work in progress badly:

Woman has to get John Carter'd into a religious war on another planet in order to get a job with her linguistics degree

[quitealotofsodapop]

Ok but what sort of side effect does Wukong deal with when it comes to making stone eggs? Because if the usual procedure would result in a Stone Monkey's death and damage to their very soul, then there has to be long lasting effects. Is Wukong just... permanently weaker and doesn't have as much endurance as he used to? Does he have moments of chronic illness and pain? Does he lose his breath easy or have lung and/or heart problems? What does the recovery look like for Wukong?

Permanent power debuff during and even after the Stone Egg pregnancy. In addition to a lot of typical pregnancy symptoms... for the next few centuries.

So much energy is needed just to form the egg, that having the parent "awakened" and surviving the process puts a *Huge* biological pressure on the body.

Wukong experiences a much weaker immune response than normal - his divine body and immortalities no match for regulatory T-cells keeping his immune system dampened to protect the Egg and/or to reduce post-partum inflammation. First time he ever caught a cold on the Journey - he thought he was dying cus he'd never experienced that kind of illness before. Spent the rest of the Journey super sus of anything that could get him sick. Same in the modern day; huge advocate for vaccines and mask-wearing. He wont die of illness, but he'll feel like it.

Chronic pain in his lower back and abdomen for like ever. Wukong's body argues with him after the baby arrives since it's been the same shape for hundreds of years, and it takes a while for him to stop having post-partum afterpains. Lots of heat packs, cold compresses, and massages from Macaque are needed to soothe this sore monkey.

Wukong also retains a bit more water afterwards (normal hormonal thing) so his ankles still swell up at odd times.

Gets short of breath a lot faster than he used to. Just something he has to deal with now.

Slightly gross but 100% normal post-partum symptom; Wukong is left with some issues making to the bathroom on time for the next few months or so. The Egg wrecked his "downstairs" on the way out.

Aesthetically; Wukong gets left with some gnarly stretch marks that are really hard for him to glamour off and it makes him a little self-conscious, but he's really proud of them esp since the marks are literally scars from surviving the Stone Egg pregnancy.

Most of the symptoms don't stack (thank buddha) when the lunar node twins happen, but Wukong does experience bonus morning/midnight sickness with them.

[wazzappp]

Retroviruses got me fucked up

@moosemonstrous are u ready for a dissertation? I hope so.

people who followed me for art I'm so sorry

ALRIGHT so we're gonna cover a couple areas.

General information about retroviruses.

Details about The Corruption and theories about how it works inside the body.

SPECIFICALLY ROBBIES viral weird shit. Cause what he has going on is even more fucked up than normal fucked up. Fucked up squared.

Me ranting about skin necrosis and why I shouldn't have just. Thown it in there because I thought it would look fucky wucky.

GENERAL INFORMATION ABOUT RETROVIRUSES:

As most people know, a virus is a cell that enters the body of a host and alters its DNA to turn that hosts cells into virus making factories. This is what allows viruses to duplicate and spread through the body so quickly. But whats that? 'What makes retroviruses different from other viruses?' I hear you asking? WELL EXCELLENT QUESTION THATS A PERFECT PLACE TO START. A retrovirus is different because its method of self duplication involves an enzyme called reverse transcriptase. This makes retroviral infection PERMANENT. Even if the virus is defeated by the immune system, those changes stick around. The phrasing used was 'ipso facto mutagenic' meaning 'by the fact itself/inevitable'.

...Which is kinda metal honestly I want it on a tee shirt (definetly not thinking of Amadeus saying that to Robbie as he tries his best to explain theres no way to undo whats going on with him. nahhhh angst don't got a hold on me like that [<- vibrating])

'Ohhh but if those genetic changes never go away, doesn't that mean that those viruses will get passed on through peoples children?' ASKING SUCH GOOD QUESTIONS TODAY MY MUTUAL BECAUSE THE ANSWER IS YES. Once a retrovirus codes itself into a hosts gnome, its called a provirus (pro gamer move right there) Fun (not fun) fact around 8% of the human gnome is made of proviruses. These are called endogenous viruses, and for the most part they just kinda sit there and stay dormant. TERRIFYINGLY, other viral infections can trigger these endogenous viruses out of dormancy. As for what actually causes a provirus to go dormant uhhhhhhhh I dunno. Couldn't find an answer in my research someone make me look stupid with an answer please because I wanna know.

Ok now lets talk about the immune system a little bit. There are a few different kind of cells at work (hehehehehe) that help to fight viruses and other infections in the body. The first are Cytotoxic T cells or Killer T Cells. These are the cells that directly destroy cells displaying genetic patterns they recognize as bad. Next we have CD+4 Cells (Helper T Cells) which act as a library that stores information about how to identify an infected cell, and shares that information with other Killer T cells once one figures it out. Then there are the Regulatory T cells which suppress your immune responses to maintain homeostasis. They're what (USUALLY) stops your immune system from killing you while trying to clear a virus. Last there are Macrophage. CELLS AT WORK MAID MILFS- I mean cells that clear the debris that remain after the Killer T Cells are done destroying them.

Retroviruses have two primary ways of either side-stepping the immune system or just. Overwhelming it completely. Acutely transforming retroviruses do just that. They reproduce too quickly for Killer T cells to destroy them all and exhaust the system. The second type are called Non Acute Retroviruses. They camouflage viral particles as immune cells to suppress the immune system. For example, HLTV-1 is a retrovirus that disguises itself as a Regulatory T cell to artificially suppress the immune response thats trying to kill it.

HTLV-1 is really interesting because most of the time patients are asymptomatic, but 5% can graduate to HTLV-1 associated myelopathy/tropical spastic paraparesis, which affects the spinal cord and white matter of the central nervous system. This usually results in the weakening of lower extremities and sometimes total bowl/bladder control loss. It suckkssssss (but is also a retrovirus that affects the central nervous system so were circling back to it later 👀).

SPECULATION ABOUT THE CORRUPTION:

I've said previously that The Corruption has potential for a retrovirus that affects the central nervous system by degrading the brains ability to regulate muscular contraction, while also pumping out a ton of cortisol and adrenaline to encourage 'hysterical strength'.

Now I did a little more research about Hypoglycemia and combined with the nerve damage people would likely die from cardiac arrhythmia, which is a life threatening kind of ventricular fibrillation. Long and short, it means their hearts don't have the proper energy and stimulation to keep beating properly, so they stop beating in sync. This results in insufficient blood flow to vital areas like the brain, and combined with the inadequate blood sugar, this would result in very fast brain death.

Let's talk about the immune systems response to this Corruption retrovirus. We would most likely see lots of inflammation, and with the main focus being on nerve cell this would probably result in meningitis, which is inflammation of the tissue surrounding the brain and spinal cord. If left untreated this could result in a coma and then death. So we're seeing a SHIT ton of pressure on the brain and central nervous system. Which is like. VERY BAD for a person. We're talking brain death very very fast.

As for how the virus would target the nervous system directly we could look to real world examples like rabies (ahhhh rabies. can never get away from you). The virus would attach to nicotinic acetylcholine receptors, which are what turns chemical signals into electrical signals in your nerves. It would then spread through the axons of the central nervous system and eventually reach the brain. We could also pull a rabies with 'once you see symptoms it's too late' which I, personally, find fucking terrifying.

In terms of the virus losing its effectiveness once outside the body of a Demon/Kaiju we would likely need to look at the anatomy of a retrovirus itself. The outermost area is composed of envelope spikes, which tell the cell to let it in. After that is an envelope protein which plays an important role in complete virus particle (virion) assembly. Theres then a protein shell that contains reverse transcriptase and the RNA gnome that it will use to recode a host cell. If this virus evolved to survive in an environment that is always warm (hell. lol. lmao.) it might not be prepared to deal with these colder temperatures in our world. This could result in damage to the protective protein barriers and cause damage to the real important parts, the RNA and reverse transcriptase. This would mean that the virus would not be near as effective as a fully intact retrovirus cell.

The Corruption could be an endogenous virus thats embedded into the Demon/Kaiju gnome that wouldn't affect them, but would absolutely affect us because we haven't seen them before.

ROBBIES WEIRD FUCKSHIT:

alright guys this is where we put the FI into SCIFI cause your about to read a whole lot of nonsense sentences.

Robbie. Robbie is fucking WEIRD in EVERY universe and this shit is absolutely not different. Him being exposed to that previously mentioned damaged version of the virus from a young age might not give him true immunity but it would give him SOMETHING to work with. His immune system is at least slightly familiar with it and at this point whatever damaged version he came into contact with has already established itself as a provirus in him.

The Corruption thats established itself in The Charger is different.

Like I mentioned in my first diagram, I think there was a chemical reaction that stabilized the corrosive aspect of The Corruption, but this reaction would also have had an effect on the retroviral properties of the Demon/Kaiju material. ESPECIALLY when we add Eli into the mix.

Now, I think generally the amount of radiation that these viruses would be exposed to would kill them (if you believe viruses are alive. there is some MEGA debate going on about that). But if the corruption was just stabilized/hardened on the outside and left squishy and organic on the inside, that would successfully protect everything. And whats that organic squishyness on the inside? EXCELLENT QUESTION AGAIN. If Eli died while inside The Charger then it's not a stretch to think his DNA would have been incorporated and stored via through the natural processes of the retrovirus as a provirus. And so you end up with the genetic mixture of a horrifying creature capable of heinous acts, and a Demon/Kaiju. WITH retroviral properties. Dear god.

Robbie would get exposed to this the very first time he enters the Charger. Because of his semi-immunity + genetic relation to Eli he would likely be able to overcome the more meatsuit damaging aspects of this mixture and just get right through the genome editing without much fuss from his immune system. We would still have a certain degree of damage to his nervous system which allows for that change in strength that would occur in usual examples of the virus (maybe some added aggression from mild influence in his amygdala), but not to a deadly degree. Honestly this shit would barely classify as a virus its just. A nightmare mutagen at this point. So while some of his gnome would remain fairly the same, a good 30% to 50% is megafucked.

Changing Robbies genotype to this degree will naturally result in a change to his phenotype! For the sake of fun were gonna ignore stem cells and their weirdness (for now. I just need to stew on it a little longer and I can make up some bullshit I'm sure). The damage his muscles would experience from less regulated signals would mean they experience muscle tears and subsequent muscle growth. For usual muscle damage from exercise this takes a few days, so if we wanted to keep with that timeline it could be interesting to introduce some minorly sped up healing. That would also be fun for reactivating the growth plates in his bones to allow him to become bigger and taller overall (boring body horror my beloved @cicada-candy that term is never leaving).

THEN you can get into some of the fucky wuckier traits like tapetum lucidum and TEEF. TEEEEEEFFFF. The teeth in particular could go a few different ways. You could just have growth and development of the canines resume until they become elongated and more prominant. OR. You could replace the teeth with bony protrusions from the skull that would push out the original canines and grow in their place. Because of the time it takes for bones to heal your looking at this happening around 20 weeks out. Literally any fun trait you want to take from Demon/Kaiju could apply here.

The most important part would be the nerve bundles on his spine that would be used to bluetooth to The Charger (<- this is a nonsense sentence. I am aware of this). These would provide faster communication with the charger and (theoretically) more intuitive movement, while also allowing him to eventually controlling the charger from the outside. Please note that this would cause EXTREME STRESS to his nervous system. It would be like a person trying to flex a muscle the size of another person for the first time. LEARNING PROCESS. TAKE IT SLOW OR HAVE AN ANEURYSM.

Which leads me to the youtuber apology part of this.

WHY I SHOULDNT HAVE JUMPED TO SKIN NECROSIS:

Skin necrosis is a result of the mass death of skin cells that is furthered by the damage to blood cells. This usually results in a blackened, leathery texture to the necrosed skin. I SHOULD HAVE NEVER EVEN MENTIONED THIS.

What I SHOULD have done is said 'hmm ah yes it would make more sense for some protective covering over these nerve concentrations to either come from materials in Robbies body or to mutate into the skin of the Demon/Kaiju'. This is why we do sufficient research before getting back on our bullshit, wazz (mental note mental note mental note mental note).

I am quite partial to the idea of that stronger/thicker Demon skin/armor growing under Robbies skin and it just itches and burns until he cant ignore it anymore. And then he can pull off. Whatever skin is on the top of it. HEHHEHEHOHOHOHO DELICOUS MENTAL IMAGE of him panicking because he just wanted to scratch his back but now theres blood on his hands and skin sloughing off and dear fucking lord how did he get to this point in his life (<- I daydream about normal things guys don't worry. very average things).

ANYWAY uhhhh if you made it this far I love you. Legit. Have a cookie. Take a nap. Have a happy holidaze <3.

[theredumbrellatheory]

regulatory T cell you STUPID CUNT

[ieatcerealboxes]

T cells in a nutshell

[foolishfoolsgold]

MISC KILLER T STUFF FROM THE SPEC EVO AU

-they form super strong bonds with heir squadrons of about 6 to 10 cells, pretty much considering them found family, a lot like the MudWings in WoF. They always try to eat together, sleep together (not like in the same bed, but pretty much in a room full of bunk beds. But the squad leader gets their own room because power), sometimes patrol together, and squad leaders always try to know where everyone is and how they’re doing, and to have them all back to their home lymph node most days to catch up and relax. Basically their relationship is very familial in nature and they view each other as siblings- that means dating within your own squadron isn’t allowed.

-The reason KTs take a long time to show up to an infection is because the squad leaders will call everyone and say “GET OVER HERE!!!” And all the Ts from that squadron will go “OH SHIT” and hop on the interstate from wherever they were to go fight together bc that’s what they were raised to do. Meanwhile all the others who were just There are already going at it.

-KTs actually have a lot more marking color variation than other types of cells- while some are limited to only a sliver of the color wheel, KTs can have patterns that are black, brown, lighter tan, or even dark navy blue

-They have skinny tails with a pair of retractable perforin stingers on the end, but in a pinch, they can fling the stingers like darts to strike faraway targets. Because the entire protein comes out when this happens, it takes a few hours to grow a new one.

-Most KTs carry knives, but they like to use their natural weapons more. An example of this is their arms, full of fast-retracting filaments that can deliver forceful punches that rely on spontaneity, like a frogfish strike. In only a few milliseconds, they can pop the enemy’s membrane from the shock of the impact alone.

-KTs follow the Lymphocyte Code (or at least this version of it), and its a big source of anxiety for Ts who don’t vibe with the whole “no friends” thing! Fun fun! It reads as follows:

As a lymphocyte, my duties are dangerous and pressing. Within my stingers, I wield the extract of destruction, and I understand that if I fail to use my powers for good, I will no longer be welcome on our inviolable grounds. I promise to uphold the following principles with every lipid of my membrane, and to use them to guide myself and others as I carry out my obligations.

1. I will trust no one beyond my circles. We are immune cells, and we should always be on the lookout for the enemy. The burden of trust, be it time, words of wisdom, or sacrificial acts, cannot be wasted on those below us- it must be retained for battle, loyalty to my sector, and cells in immediate danger.

2. I will listen to my commanders. Squad leaders, Helper T cells, and Regulatory T cells hold virtue over me, and I am not to debate the orders I am given.

3. I will not be held back by fear. I understand that, regardless of emotion, I have an obligation to carry out my duties in the face of crisis, cataclysm, and anarchy.

4. I will understand my fortune. I was selected from a competitive pool of trainees because I showed superior grit, skill, determination, and dedication. I will carry this with me as I fight for our safety and the liberty of our citizens.

5. I will protect this Body at all costs. By using the above principles, I will channel my training, pride, and loyalty into a powerful force that cannot be rivaled. When the fate of our world falls into my hands, I promise to show unrelenting persistence until my final breath.

[bpod-bpod]

T for Tolerant

Single cell analyses and live-imaging in mouse gut reveals mechanisms underlying tolerance of the immune system's regulatory T cells to chronic bacterial infection and the intestinal niches where this takes place. Greater understanding of the disruption of tolerance which results in colitis

Read the published research article here

Still from video from work by Yisu Gu and Raquel Bartolomé-Casado, and colleagues

Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford and Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature, April 2024

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