#psychically linked urinary tracts

[woosh-floosh]

[missmoki]

Intro to Chakras

Photo by Danielle Barnes on Unsplash

History

The Chakra system originated in India around 1500 and 500 BC in the oldest text called the Vedas. The Vedas is the earliest Sanskrit literary records and the most ancient scriptures of Hinduism.

What is Chakra?

The term chakra appears to first emerge within the Hindu Vedas, though not precisely in the sense of psychic energy centers, rather as chakravartin or the king who "turns the wheel of his empire" in all directions from a center, representing his influence and power. In Sanskrit the word Chakra means disk or wheel and refers to the energy centers in your body. These wheels or disks of spinning energy each correspond to certain bundle of nerves or major organs. There are 7 main chakras that run along your spine, they start from the root or base of your spine and then up to the crown of your head and it is believed that there are about 114 chakras in the body.

The 7 Main Chakras

Crown or Sahasrara

Location: The very top of the head

Color: Violet or White

Meaning: Awareness, Intelligence

Element: Divine Consciousness

Stone: Clear Quartz, Selenite, Lepidolite

Develops: 43-49 Years Old

Opened: It is thought to help keep all other chakra's open and to bring the person bliss and enlightenment. When you fully open your crown chakra, you're able to access a higher consciousness.

Blocked: Those with a blocked crown chakra may seem narrow-minded, skeptical, or stubborn.

Overactive: An overactive crown chakra often manifests as a desire for material belongings which never seems capable of being satisfied. Greed, superficiality and arrogance often result in a disconnection from others as well as the universe.

To balance the crown chakra connect with the cycles of your body, Contemplate the right question, cultivate feelings of awe and be of service.

Third Eye (Brow) or Ajna

Location: Between the eyes on the forehead

Color: Indigo

Meaning: Intuition, Imagination

Element: Light

Stone: Amethyst, Labradorite, Purple Fluorite

Develops: 36-42 Years Old

Open: When it is open and in alignment, it is thought that people will follow their intuition. So you will have a strong gut instinct. Visions and intuitive hits are common for someone with an open third eye chakra. It allows you to cut through any illusions and drama to see the clear picture.

Blocked: People who have trouble listening to reality or who are not in touch with their intuition may have their third eye chakra blocked. When it is blocked it is also associated with a broad range of issues, including depression, anxiety and a more judgmental attitude. Physically it's said to cause headaches, dizziness and a slew of other brain-health issues.

Overactive: Sometimes with an overactive brow chakra we may even find our clairvoyant skills are so active that they can overwhelm or frighten us.

To balance the third eye try to identity journaling practice, teach yourself to act through your emotions and keep a dream journal.

Throat or Vishuddha

Location: The Throat

Color: Blue

Meaning: Communication

Element: Sound/Music

Stone: Aquamarine, Kyanite, Lapis Lazuli

Develops: 29-35 Years Old

Open: When it is aligned you will speak and listen with compassion, as well as feel confident because you know you are being true to yourself and your words. When it is functioning at full capacity it allows us to express ourselves truly and clearly.

Blocked: When it is blocked this can been seen through dominating conversations, gossiping, speaking without thinking and having trouble speaking your mind. You may also find it hard to pay attention and stay focused, or fear judgement from others, which can further hinder your ability keep it real. Physically, this blockage can manifest itself as a sore throat, thyroid issues, neck and shoulder stiffness, or tension headaches.

To balance the throat chakra you can try the Cat-cow pose, communicate with awareness, sing to yourself as a child and practice a mantra.

Heart or Anahata

Location: The center of the chest above the heart

Color: Green

Meaning: Love, Compassion

Element: Air

Stone: Rose Quartz, Jade, Malachite

Develops: 21-28 Years Old

Open: When it is open you may find that you feel more connected with those around you and you will be open to others. You will also be at peace with spending time alone. You may feel more joy and happiness as well as be more optimistic. You may notice that you will receive what you desire with ease. When the heart chakra is open you will also have an increased capacity for compassion and forgiveness.

Blocked: Someone with a blocked heart chakra will have difficulty to fully open up to people in their life. People with the heart chakra blocked also often put others first, to their own detriment. It can make us feel lonely, insecure and isolated. A closed heart chakra can give way to grief, anger, jealousy, fear of betrayal, and hatred toward yourself and others. You may also be emotionally closed off, and find it difficult to get over past hurts and unable to forgive.

To balance the heart chakra try to pay attention to your posture, most of us walk around with hunchbacks and unconsciously closing our hearts. You can also try writing yourself a love letter, try a metta meditation or participate in service or volunteer activities.

Solar Plexus or Manipura

Location: The upper abdomen, the stomach area

Color: Yellow

Meaning: Self-Esteem, Confidence

Element: Fire

Stone: Amber, Citrine, Pyrite

Develops: 15-21 Years Old

Open: Those with open sacral chakras are free to express their true selves. It's the chakra of our personal power. This means it's related to our self-esteem and self-confidence.

Blocked: When it is blocked people often experience digestive issues like ulcers, heartburn, eating disorders and indigestion. You may not just feel badly about yourself, but also may lead you to outwardly express apathy, procrastination or that you may be taken advantage easily.

Overactive: When it is overactive you may have a rampant ego, be power hungry and egotistical, resulting in manic behavior and hyperactive energy.

To balance the Solar Plexus try working out your core, make friends with your inner critic or practice the breathe of fire (its a kundalini yoga practice).

Sacral or Svadhisthana

Location: Just below the belly button, just above the pubic bone

Color: Orange

Meaning: Sexuality, Pleasure, Creativity

Element: Water

Stone: Tiger's Eye, Sunstone, Carnelian

Develops: 8-14 Years Old

Open: This chakra is linked to how you relate to your emotions of others. When it is aligned you'll likely feel great, you're friendly, passionate and successfully fulfilled while also eliciting feelings of wellness, abundance, pleasure and joy.

Blocked: When it is blocked you may feel a lack of control in your life. You may also feel uninspired, have some emotional instability, you may also experience fear of change, depression or addiction-like behaviors. Physically you may see problems with associated organs like a urinary tract infection, lower back pain and impotency.

To balance the Sacral Chakra try meditation or yoga, work with the color orange, maybe eat orange foods, get comfortable with stillness or maybe try journaling.

Root or Muladhara

Location: Base of the spine, in the tailbone area

Color: Red

Meaning: Physical Identity, Stability, Grounding

Element: Earth

Stone: Hematite, Red Jasper, Onyx

Develops: 1-7 Years Old

Open: This chakra is responsible for your sense of security and stability. When the root is opened you will feel grounded and secure, both physically and emotionally.

Blocked: When the root chakra is blocked it can manifest physical issues like arthritis, constipation, and bladder or colon problems. You may feel insecure about finances, basic need and well being. You may also feel threatened and as if you are standing on unstable ground. Other ailments include anxiety disorders, fears and/or nightmares.

To balance the root chakra try envisioning the color red glowing at the base of the spine where the chakra is located. Start with a simple meditation of imaging a bright red light at the base of your tailbone. Picture this red light extending down to your legs and feet, grounding you to the earth. You can also try yoga, dancing, take a shower or go on a walk, concentrate on your foot leaving the ground and connecting with the earth again with each step.

[yogaadvise]

Balancing 7 Chakras: What You Ned to Know About Chakra Alignment

Chakras as healing facilities have been main to Hindu, Buddhist, as well as Eastern spiritual practices. These are prime focus in the body that, when made use of with reflection, promote wellness.

" Chakra" translated from Sanskrit implies wheel or circle. The body is a wheel of power: just how this wheel moves, connects, as well as connects regulates the circulation of energy. A well balanced chakra system is tied to psychological handling, resistance to disease, as well as physical health.

Chakras can end up being misaligned, obstructed, or subjected. Obstructed energy can bring about ailment or psychological pain. Therefore, chakra "harmonizing" can be used to recover energy and wellness.

There are 7 major chakras of the body. Each one is connected with a color, mantra (a word or noise repeated throughout reflection), and a put on the body. With each other, yoga positions, reflection, as well as conscious nutrition, can be utilized to bring back chakra alignment.

Chakra 1-- Root (Mooladhaara)

Color: Red

Location: Base of the spinal column in tailbone. This chakra is closest to the planet, and is consequently related to grounding as well as survival. In the body, it is gotten in touch with legs, feet, bones, as well as the colon. A balanced origin chakra permits an individual to feel safe, secure, and also provided for.

Signs of over-activity: Paranoia, stress and anxiety, anxiety based upon the demand to make it through. Joint pain, digestion troubles, low back pain, hip pain, swollen feet.

Signs of underactivity: problem concentrating, lack of energy or confidence, airheadedness. Foot and leg injuries, gastrointestinal troubles, immune disorders.

How to stabilize your first chakra: Make sure that all basic survival needs are fulfilled. Beneficial practices consist of walking barefoot on the dirt or turf, relaxing the spirit through prayer, reestablishing personal origins, and exercising grounded yoga poses. Meditate: using the mantra Lam, or affirmations such as, I am based, I am safe, I am secure.

Yoga poses: Mountain, tree, warrior, side-angle, and bridge positions to assist in grounding.

Essential oils: Cedarwood, incense on wrists or lower back before sleep.

Supportive foods: Red-colored foods-- red apples, beetroots, pomegranates, cranberry, radishes, red potatoes, red lentils. Root vegetables, mushrooms, pet proteins (meat, eggs).

Chakra 2-- Sacral (Swadhishtana)

Color: Orange

Location: Halfway factor between the root chakra and also the navel. This chakra is connected with a sense of wellness, satisfaction, and sexuality. In the body, the sacral chakra is connected to the reduced abdomen, kidneys, bladder, blood circulation system, and also reproductive organs. A well balanced sacral chakra advertises joy, healthy and balanced connections, imagination, a sense of consistency, and also feeling satisfied.

Signs of over-activity: Obsessive behavior, absence of self-acceptance, mental illness, sexual regret, addiction, and also uneasyness. Irregular bowel movements, pain in the back, the inability to conceive, or urinary tract infections.

Signs of underactivity: Loss of pleasure in daily tasks. Depression, erectile dysfunction, stunted creativity, lack of passion.

How to stabilize your second chakra: Emphasis on activities that are nourishing for the heart and spirit-- ask, "Is this great for me? Is this healthy and beneficial?" Healing this chakra involves nurturing the heart and taking joy in the straightforward things in life: food, partnership, sex, as well as hobbies. Be near water.

Meditate: with words Vam, or affirmations such as I am healthy and balanced, I am creative, I am calm.

Yoga poses: Bridge position, cobra posture, forward bend, sitting forward bend, bound angle pose.

Essential oils: Jasmine, sandalwood, climbed, ylang ylang

Supportive foods: Oranges, tangerines, nuts, cumin, turmeric, ginger, orange-colored origin vegetables (carrots, squash). Foods with a high water web content, foods with vitamins A, B, and also C.

Chakra 3-- Naval/Solar Plexus (Manipura)

Color: Yellow

Location: Above the naval, prolongs upwards with the chest. Glowing an intense yellow shade, it is connected to sensations of confidence as well as control. A balanced marine chakra advertises sensations of worth, warmth, and also count on yourself and also instinct. In the body: a healthy digestive tract, reduced tension, normal rest, and well balanced hormones.

Signs of over-activity: Short-tempered, managing actions, greed, absence of concern, lack of ability to keep eye get in touch with. Digestion trouble, over active nerves, adrenal tiredness, unhealthy rest habits.

Signs of underactivity: Indecision, insecurity, neediness.

Healing the 3rd chakra: Reflection, breathing workouts, and doing slow-moving yogic spins outside. Releasing belly muscles.

Meditate: with the mantra Ram or affirmations such as I merit, I am positive, I am strong.

Yoga poses: Sun salutation, warrior, backbends, bow, half-twist, and also boat poses.

Essential oils: Ginger, rosemary, or lemon

Supportive foods: Yellow-colored foods: corn, bananas, applesauce, grains, chamomile tea with lemon as well as ginger. Foods that advertise digestive health: aloe juice, avocado, mint, kefir, yogurt, cinnamon, celery, as well as cucumber.

Chakra 4 — Heart (Anahata)

Color: Green

Location: Facility of the upper body, above the heart. The heart chakra connects to love, concern, calmness, and harmony. A balanced heart chakra manifests with a strong heart, immune system, and circulation. It is linked to feelings of love, compassion, compassion, and also healthy choices.

Signs of over-activity: Sensations of isolation, loneliness, panic. Heartburn, anxiousness, upper body stress, shortness of breath, and elevated heartrate.

Signs of underactivity: Depend on concerns, failure to get in touch with others. Despair, depression, poor blood circulation, breathing problems.

Healing the 4th chakra: Concentrate on deep breaths to get rid of the lungs, open up the shoulders, and also open the chest. Exercise self-care activities to route external love to yourself.

Meditate: with the rule Yam or the affirmation I am compassionate, I am open.

Yoga poses: Chest-openers: camel, cobra, fish posture. Attempt this 30-minute yoga exercise regimen to open up the heart chakra.

Essential oils: Rose, thyme

Supportive foods: Eco-friendly, nutrient-rich veggies: leafed environment-friendlies, spinach, kale, cabbage, broccoli, dark lettuce. Alkalizing fruits as well as veggies: green apples, limes, zucchini, celery, avocados, eco-friendly beans.

Chakra 5 — Hroat (Vishudda)

Color: Blue

Location: Throat Tied to the ability to interact, self-expression, as well as talking the truth. A balanced throat chakra suggests you can speak clearly with truth and compassion. Healthy and balanced glands, thyroid.

Signs of over-activity: Really feeling ignored, revoked, inability to talk the fact. Thyroid or hormonal agent inequalities, throat pain, frequent infections, or ulcers.

Signs of underactivity: Shyness, lack of ability to share your emotions.

Healing the 5th chakra: Talk with truthfulness as well as brevity. Method revealing your feelings and also truths, also alone. Remaining in or near water, strolling under the sky, paying attention to noises of water or wind.

Meditate: with the rule Pork, or affirmations that advertise strength and also self-respect: I share myself honestly as well as plainly, I am balanced.

Yoga poses: Fish, lion, or bridge presents. Neck stretches, shoulder openers, supported shoulder-stand, camel, and also rake poses.

Essential oils: Eucalyptus, sage, blue chamomile

Supportive foods: Nutritional foods with a high water content, clear fluids and also broths, herbal teas. Juices, fruits, as well as blueberries. Mineral water.

Chakra 6 — Third Eye (Anja)

Color: Indigo

Location: Facility of the temple, in between the eyebrows. This chakra is connected to reflection, wisdom, decisiveness, and instinct. A well balanced 6th chakra promotes a feeling of unity, convenience, as well as hearing your instinct. Connected with audio rest and pituitary gland health.

Signs of over-activity: It is unusual for people to struggle with an overactive Pineal eye. Those that do may invest a lot of their time fascinated in psychic tasks, such as paranormal experiences and also astrological readings.

Signs of underactivity: Absence of insight, mental instability, poor memory, feeling disconnected, judgmental behavior. Dizziness, loss of sight, tension headaches, depression, or sinus infections.

Healing the 6th chakra: Solitary meditation is the most effective method for recovery this chakra. As are simple repeated tasks, such as treking or long walks outdoors. Browse through all-natural landscapes that give perspective.

Meditate: with the concept Om or affirmations such as I am directed, I am centered, I am clear.

Yoga poses: Kid's position, standing forward bend, modest warrior, warrior III, as well as seated meditation.

Essential oils: Sage, bay, or jasmine

Supportive foods: Raw nuts: almonds, walnuts. Purple-colored foods, such as: grapes, plums, goji berries, acai, eggplant, or blueberries. Cleansing foods, such as: pineapple, mushrooms, grains, papaya, and also cruciferous vegetables.

Chakra 7 — Crown (Sahasrara)

Color: Violet - White.

Location: On the crown of the head. The crown chakra is connected with the connection to spirituality. A balanced crown chakra is linked to sensations of bliss and a healthy central nerves. Calm, centered ideas, and also the ability to touch right into a greater level of spirituality. This is the goal of every spiritual practitioner, and also it is tough to attain a completely balanced crown chakra.

Signs of over activity: Like the Buddhist principle of "paradise," it is not possible to have an overactive 7th chakra due to the fact that it would indicate one is no longer human.

Signs of underactivity: An underactive 7th chakra is regular: every human has an underactive 7th chakra. Indications consist of inability to focus, imagining, as well as not residing in today. Migraines, misconceptions, as well as tight joints.

Healing the 7th chakra: Straightening this chakra is best done with reflection and also stabilizing the other 6 chakras. Add daily exterior strolls to your regimen, concentrate on being existing, and cultivate gratitude.

Meditation: advised without a mantra. Usage affirmations such as I am present, I am here, I am connected.

Yoga poses: Balancing postures that bring recognition to the body: tree, hill, as well as eagle poses.

Essential oils: sandalwood, geranium, myrrh

Supportive foods: Water soaked up through the skin, sesame or chia seeds, bone broth, topical necessary oils, and also aloe vera juice. Because this chakra is tied to the spiritual, the crown chakra is probably to gain from sunlight, fresh air, and silent meditation.

[worldofcrystals-blog]

Instagram: What Ancient Practice That We Still Do Today (link blog)

When most people think of western medicine, they think of hospitals, immunizations and medication. Humans have been healing themselves of physical, mental and spiritual ailments. The oldest stories of crystal healing date back to ancient Atlantis. Some believe the practices grew through Egypt, South America, and Tibet. 

Kings in India collected these gems of high quality to protect themselves to stay away from harm. Ancient China was ahead of their time using crystals, they would use needles made of Green Jade for acupuncture. It was especially used for the gallbladder and kidneys and used for digestion and urinary tract issues. Ancient Japan used crystals for prophetic and psychic practices, highlighting their connection with their intuition using quartz. Tibetan Buddhists’ main crystal used in medicine was Lapis Lazuli, meditating with this crystal was believed to enhance health also helping heal the mind, body and spirit. They mostly used spherical Quartz to help calm the mind and help them reconnect with higher power. Mayan and Aztec lands had a lot of obsidian, used for scrying and divination, among all other practical purposes. 

Today, research has proven by quantum physics that crystals have vibrations and contain a power and dense healing energy. They have a powerful energy field and have absorbed and been affected by numerous physical and chemical reaction that make them very powerful healers.

[healthinputs]

50 Natural Remedies for Common Health Problems

Natural  remedies are no longer a complement to drugs. For more and more people, the best way to combat - and prevent - diseases of modern times is with some doses of nature. It is significant that, in times increasingly mediated by great medical advances, the treasure of traditional medicine is being rediscovered . Undoubtedly, this trend is linked to the thirst for nature that causes our artificial, synthetic and sedentary life. And also to the fact that it is precisely that lifestyle that is putting collective health in check. In that sense, trying to cure ourselves only through drugs is to enter a vicious circle. Because sometimes those same medications cause us terrible side effects . And because they are not made to prevent diseases, but only to cure them, which says a lot about the contemporary mentality (cure as soon as possible, but do nothing to prevent). So returning to a healthier lifestyle involves getting closer to nature: performing ecotherapies - even if we are in the city - as well as getting closer to the benefits of fresh foods that promote longevity . And not least: make use of healing plants and flowers to prevent or treat common health problems. 1. Anemia: green leafy vegetables and citrus

Green leafy vegetables such as kale, lettuce, spinach or chard have a lot of iron, of which there is a deficiency when we suffer from anemia. But to absorb iron you also need to take citrus fruits and fruits with vitamin C, such as grapefruit, kiwi and orange. 2. Anxiety: passionflower The passionflower, also called passionflower, is the flower of the passion fruit tree. It has incredible antioxidant effects and essential oils whose effect is analgesic and relaxing. That is why it is recommended to take infusion. Its anxiolytic action is so potent that it is even used to reduce tobacco, alcohol or food withdrawal syndrome. 3. Asthma: Gordolobo The Gordolobo is a hairy-looking Mexican plant. But do not worry! Infusion is delicious and very effective in treating asthma. You just have to cook its branches and flowers in 1 liter of water and drink three hot cups of infusion with honey a day. 4. Arthritis: Turmeric This strong herb has been used for millennia in Indian Ayurvedic medicine. It helps mainly against arthritis since it controls inflammation. You can find it in powder to use it in dishes, but it is better to drink it in tea. Just slice a medium piece and boil them for 5 minutes. 5. Hair loss: spinach and berries Spinach has iron, which helps prevent oxygen deficiency in the body, which helps prevent hair loss. You can consume it in a smoothie made of almond and berry milk - such as blackberries, blackberries and blueberries - which, due to their vitamin C intake, help in the formation of collagen, which is responsible for keeping hair strong. 6. Dry hair: castor oil and soybean oil Castor is an African plant, whose oil is easily available in stores specializing in oils and essences. It is like the vitamin E capsule - so famous in hair treatments - but of nature, because it has a lot of said vitamin, as well as essential fatty acids. You only have to apply it at night on the scalp and hair after rubbing it on the hands. 7. Hair loss: egg white Beat four whites and rub them on the scalp with circular movements. Leave on for half an hour, rinse and wash. The egg white has albumin, which strengthens the hair follicles and strands. 8. Dandruff: white vinegar It contains acetic acid, which creates an environment in the scalp where fungi and yeasts cannot grow. Just wash your hair with a mixture of water and vinegar (one part of vinegar for every three of water), and let it act for 4 minutes. 9. Colic: pericon Infusing this plant with the smell and taste of anise can help you effectively against colic. But you have to do it before they start, or as soon as you start to feel pain. Cook the stems: they are the ones that will release the most oils in the infusion. 10. Colitis: oak This plant can help reduce symptoms of colitis because it reduces excess fluids in the intestine. A piece of its bark (like a teaspoon) is used in decoction to make a glass of water. To relieve diarrhea, 3 glasses are taken daily. 11. Conjunctivitis: parsley A juice with parsley, carrot and celery helps improve vision and acts on the eyes and optic nerve. 12. Control weight: nuts Foods with polyunsaturated fats, such as nuts, almonds or pistachios, help you feel full and provide you with benefits that saturated fats do not have. Eat what fits in a fist of your favorite type of nut. 13. Itchy skin: propolis Propolis has flavonoids, which are antioxidants and regenerators of cell damage. It also has analgesic properties. For all this, applying it to the skin helps remove the itching immediately. You can get it in atomizer in health food stores and pharmacies. 14. Vaginal itching: yogurt It is usually caused by fungi. If so, you can apply yogurt directly and let it act for 10 minutes. It will relieve you, but also its probiotics will regenerate the flora of your vagina and kill the bacteria that are causing the damage. Do it every day for a week. 15. Depression: bananas Bananas have tryptophan, an essential amino acid that stimulates nerve functioning and increases serotonin levels. Therefore, including this delicious fruit in the diet is a great complement to avoid psychic imbalances. 16. Diabetes: dandelion You can prepare some infused leaves or eat them in salads. They serve to regulate blood sugar. 17. Diarrhea: rice water To stop diarrhea you must prepare 1 cup of rice in 4 cups of water for 20 minutes over low heat. You can drink up to 3 cups of water, warm or at the same time. It really works because it helps you regulate the intestine, and stops stomach irritation because of its starch content. 18. Erectile dysfunction: aloe vera  Yes: aloe vera regulates blood capacity. This helps prevent erectile dysfunction, which is caused by poor circulation. You can take it in smoothies , adding aphrodisiac ingredients such as almond or dark chocolate. 19. Headache: Basil Basil is a noble plant that you can take in infusion, cooking some leaves for 2 minutes. It helps relieve headaches that are not caused by unstable blood pressure. 20. Hip pain: turmeric and ginger This duet is an ancestral anti-inflammatory. Take an infusion made with some slices of both plants every day, and the pain in bones and joints will disappear. 21. Sore throat: sage Boil two teaspoons of sage in a cup of water for ten minutes. Strain and add a teaspoon of sea salt. Gargle when you feel a throbbing pain. 22. Kidney pain: blue stick This maderita is used in an infusion that adopts a blue color with golden nuances, and that is super effective to clean the kidneys of the painful sand. Therefore, it is also an excellent way to prevent the formation of stones. You just have to cook a few pieces and drink 1 liter of water during the day. 23. Toothache: guava leaf The leaf of the known fruit has anti-inflammatory qualities, so they are used to relieve toothache, gargling with an infusion at the time. You only have to boil 40gr of leaves in a liter of water and gargle 2 times a day or when you have discomfort. 24. Stress: lavender and hot bath The wash can be taken as an infusion to relax. But, alternatively, you can take a hot bath with the essential oil of this plant, which will relax your whole body and your system - it is a way to inhale the beneficial steam of lavender. 25. Pimples: apple cider vinegar You just have to rub some apple cider vinegar directly on the pimples before sleeping. 26. Fatigue: yerba mate Yerba mate is an excellent energy that helps concentration.  It is very bitter, but you can sweeten it with a little honey. 27. Gastritis: coconut water Coconut water has fatty acids that favor the digestive system. But they also have an anti-inflammatory effect, and since gastritis is inflammation of the stomach lining, the best way to counteract it is with a natural anti-inflammatory such as coconut water. 28. Flu: ginger, turmeric and garlic This combination is infallible to treat the flu. Garlic is a potent antibiotic, ginger a great pain reliever and turmeric is a detoxifier. The combination of these three ingredients in an infusion with honey not only tastes better than you might expect, but it can cut the flu better than any medically synthetic. You can even take it to prevent colds (you will see that you will survive the winter without a single flu). 29. Hemorrhoids: potato Stripe a potato and make a small compress with a piece of cloth. Apply it in the area for several minutes, several times a day. Potato starch will help relieve symptoms and reduce inflammation. 30. Infected wound: honey Honey is a natural antiseptic that inhibits bacterial growth thanks to its high concentration of carbohydrates. Putting some honey on an infected wound will help its rapid healing. It also calms the pain and helps heal. 31. Foot fungus: vinegar You just have to soak your feet for 20 minutes in a solution of water with a glass of vinegar. Try to do it for 1 week and see the results. 32. Indigestion: mint Peppermint has long been the best digestive. Having tea from its aromatic leaves will help you feel much lighter. 33. Urinary tract infection: Jamaica To prevent or treat urinary tract infection, you have to put a fist of flowers in 1 liter of water and boil for a few minutes. You should drink this water throughout the day, preferably without sugar. If you have discomfort, you will see that they will disappear in a few hours. 34. Insomnia: St. John's wort If you have a cup of tea made with this herb, you will sleep very well. But its effect is so powerful that you have to be careful: use only what you manage to take with your index, middle and thumb fingers. 35. Bad breath: oil  It has been proven how effective the oil is - olive or coconut oil - to treat bad breath, thanks to its antibacterial properties. You just have to take a spoonful and keep it in your mouth for 20 minutes. Then just rinse and brush your teeth. 36. Bad body odor: chlorophyll Drink chlorophyll: it is a pigment that has hemoglobin, a molecule that carries oxygen and helps regulate a lot of things in the body (such as red blood cells). For this reason, it has been proven that it helps against body odor. You just have to add a teaspoon to a liter of water that is your use water. 37. Bad smell in feet: baking soda and lemon The bicarbonate absorbs bad odors, which makes it a very little invasive remedy against bad smell, since it does not suppress the flow of sweating, but prevents it from causing a bad smell. If you combine it with lemon - which is antiseptic - you will see that the bad smell will stop insisting every time you take off your shoes. 38. Bruises: onion Allinase is a natural substance that helps stimulate blood circulation. That is why it is enough to apply a slice of onion on the affected area of the stroke, and thus bruises will not appear, or will be less prominent than they could be. 39. Irritated skin: green tea A cup of green tea previously cooled and gently applied with a cotton helps accelerate the recovery of the skin, especially after exposure to the sun or free radical toxins. This is because its assets stimulate tissue repair. 40. Burns: honey If it is a first or second degree burn, honey will help relieve or restore tissue. Just apply it to the entire wound, leaving only a small space for the skin to breathe. 41. Reduce bad cholesterol: dandelion Taken as an infusion, the leaves of this flower contribute to reducing the levels of bad cholesterol, because their properties decrease the synthesis of this in the blood. You can consume it three times a day if you have high cholesterol and check that after 1 week, it will have gone down. 42. Regular menstrual cycle: raspberry leaf For women it is always good to take this plant as an infusion, because it generally fights the symptoms of all phases of menstruation. But above all, it is useful for regulating hormones, which in turn regulates the menstrual cycle. 43. Hangover: Coconut water and bananas The coconut water will rehydrate you and return the lost electrolytes, while the banana will replenish all the potassium you have lost (because excess alcohol causes you to lose potassium). 44. Nasal flow: warm salt water A solution of warm salt water helps clean the mucus and reduce swelling in the nose due to its anti-inflammatory effects. You should use half a teaspoon of salt without iodine in a small glass of water. Then put a little of the mixture in the palm of your hand and inhale it. And finally, blow your nose gently. 45. Sinusitis: eucalyptus Eucalyptus has very powerful anti-inflammatory properties. To treat sinusitis you have to cook a handful of the eucalyptus leaves and vacuum the vapors, covering your head with a towel. Stay like this for the duration of the steam. 46. Excessive sweat: potato Before leaving home, place a slice of potato under your arm for less than 1 minute in your armpits. You will see that you will sweat much less, because the potato helps absorb excess water thanks to its potassium content. In fact, it is also good to consume it, because potassium helps against fluid retention that can cause excessive sweat - that is, the water retained by sodium leaks from other places, such as your pores. 47. Cough: lemon with salt and pepper Nothing is simpler to cut the cough immediately than to suck half a lemon with salt and pepper. This combination covers the throat, deflates and disinfects it. 48. Weak nails: coconut oil Massage your nails daily with a little coconut oil: this will gradually strengthen them. 49. Varicose veins: horse chestnut The active ingredient of its essence, aescina, helps promote better blood circulation. A daily dose of one hundred milligrams of this tree extract is enough, which can be taken in a little water. If on top of that you go for a walk 30 minutes a day, you can say goodbye to varicose veins 50. Vomiting: cedron Tendron tea is used in traditional Mexican medicine to relieve vomiting and nausea. It is also antispasmodic, which is useful if you also have stomach aches. Read the full article

[reikigrandmaster-blog1]

REIKI’s influences the body’s AURA, CHAKRA & MERIDIANS

Reiki supports the body’s functions through its energy systems of the Aura, Chakras and Meridians.  Reiki started out as a Japanese technique for stress reduction and relaxation that also promotes healing.  It was originally administered by “laying on hands” and was based on the idea that an unseen “life force energy” flows through us and is what causes us to be alive. It was and still is believed that if one’s “life force energy” is low, then we are more likely to get sick or feel stress, and if it is high, we are more capable of being happy and healthy.

The word Reiki is made of two Japanese words – Rei which means “God’s Wisdom or the Higher Power” and Ki which is “life force energy”. So Reiki is actually “spiritually guided life force energy.”  So, Reiki refers to a Japanese technique and it is also is a word that has come to mean the Life Energy that animates a person’s physical body.

Reiki is a form of energy healing that is achieved through initiation.  It is passed from Teacher to Student by means of an attunement.

A Reiki Attunement is the process for a Reiki Master to pass on the Universal Life Force Energy to their Student, so that they can use Reiki to heal themselves and others. Through the Attunement process, a person is able to access the Universal Life Force Energy in order to heal and balance a person, place, or situation.

Everything in creation is made up of electromagnetic energy vibrating at different frequencies that correspond to sound, light and color.  The existence of electromagnetic fields around every object in the world – known as the Aura- is a scientifically proven fact. The Japanese refer to this energy as ‘Ki’ (pronounced Key), the vital life force energy of the Universe, present within every living thing.  Western medical science is now beginning to take a serious look at ancient Far Eastern traditions that focus on Ki, the life force energy which flows through the body pathways – known as meridians & chakras – of all living forms, all beings, in order to maintain health and wellness, mentally, physically, emotionally and spiritually.

Ki has been written about and studied for over ten thousand years, from Japan and China to India, the Hawaiian Islands and South America. Ki is the energy of life itself, recognized as the balance of Yin and Yang (male and female, positive and negative, electromagnetic energy), which flows through everything in creation. Ki is at the foundation of many health and fitness practices such as Massage, Yoga, Martial Arts, Reiki, Pranic Healing, Feng Shui, Acupuncture and Acupressure.

The energy of Ki emits vibrant, bright colors (the aura), a vibrational frequency, and a sound. When Ki becomes disturbed, stagnant, imbalanced or depleted, dis-ease and illness begin to take form – the aura becomes darker and discolored, personal frequency vibrates incorrectly, and the meridians (energy pathways – Chinese origin), and chakras (energy centers – Indian origin), within the body, become blocked.

CHAKRAS:

PURPLE – I KNOW:

1Crown Chakra – Located at top of head.

2Connection to higher spiritual realms.

3Associated with helping congestion and sinuses and in calming the nervous system.

INDIGO – I SEE:

1Third Eye Chakra – Linked to the Pineal Gland.

2Connected to the higher self, intuition and psychic abilities.

BLUE – I SPEAK:

1Throat Chakra – Parallel to the thyroid gland – All about communication.

2Blockages manifest as insomnia, inflammatory conditions, stress, tension, migraines, skin problems.

GREEN – I LOVE:

1Heart Chakra – related to the thymus and the heart – balance and harmony.

2Blockages manifest as heart or immune system problems, lack of compassion.

3Green is believed to influence cell structure and muscles.

YELLOW -I DO:

1Solar Plexis – related to the pancreas, digestion, liver and outer adrenal glands

2The seat of our emotions. Blockages manifest as anger, sense of victimization, poor me, resentment.

3Yellow may be used to relieve rheumatism and arthritis – it is also believed to cleanse the body.

ORANGE – I FEEL:

1Spleen Chakra – Located beneath the navel.

2Home of creativity, vitality, sexuality, joy, hormones, kidneys, urinary tract and reproduction.

RED – I AM: 

1Base/Kumdalini/Root Chakra – Located at the base of the spine.

2Red stimulates circulation and raises blood temperature.

3This chakra grounds us in the physical, related to security and survival.

AURA ANATOMY: THE SEVEN AURIC LAYERS

When it comes to the aura, you might envision a cloud or field of energy surrounding the human body, and you’d be correct. But what you may not know is that the auric field is composed of several layers, rather than just one.  These subtle bodies of color emanate from a person’s main chakra.  Each chakra  has its own qualities and characteristics and is a power plant generating energy of a different type and color.  The strength, activity and color of each chakra depends on the person’s character, personality, emotional state and lifestyle.  A person’s dominant chakra generate the main aura color.

The First Layer of the Aura:  ETHERIC LAYER

This is the first layer closest to your physical body. It emanates from the root or first chakra and forms the connection between your physical and higher bodies. It extends anywhere from one quarter inch to two inches outside the physical body. This layer can indicate potential diseases that will develop in the physical body.

The Second Layer of the Aura:  EMOTIONAL LAYER

This layer corresponds to the solar plexus chakra and resides about one to three inches away from the body. As the name implies, this is where your emotions come into play. How you feel or perceive your feelings will show up on this layer. Any blocks or negative emotions will be seen here, usually as holes or dark spots.

The Third Layer of the Aura:  MENTAL LAYER

The third layer relates to the solar plexus chakra and is dependent upon the vibrations or your thoughts and mental processes. It extends about three to eight inches away from the body.

This layer is also influenced by your ego and will power. If you have any self-doubts or limiting beliefs, they will show up here. Likewise if you are confused or lack mental clarity, this layer will be out of balance.

The Fourth Layer of the Aura:  ASTRAL LAYER

The astral layer relates to the heart or fourth chakra and is located about twelve inches from the physical body. This layer brings together the lower three and the higher three auric layers, acting as a bridge between the denser physical vibrations and the higher spiritual ones. It is also called the astral body or the entrance to the astral plane.

This is considered the layer of love. Here we understand and express our feelings and relationships with others. Although the second layer pertains to emotions, the fourth gets into the higher octaves of care and compassion. Negative expressions can result in judgments and attacks on the self and others, also known as “hardening your heart.”

The Fifth Layer of the Aura:  MANIFESTATION LAYER or ETHERIC TEMPLATE

This layer corresponds to the throat or fifth chakra and extends about eighteen inches from the physical body. Here is where you manifest things out of ether into the world. It is the blueprint for everything you create on the physical plane, including your identity or personality.

Negative effects can result in changes on this layer that eventually show up as negative thoughts, emotions, physical disease and distorted personality aspects.

The Sixth Layer of the Aura:  HOLOGRAMATIC or CELESTIAL LAYER

The third eye or sixth chakra corresponds with this layer, approximately twenty-four inches away from the physical body. Your perception and intuition are highlighted here.

Projections and illusions can be understood or distorted based on positive or negative vibrations. It has been said that we exist in a hologram—how you perceive it depends on your consciousness and connection with the divine.

The Seventh Layer of the Aura:  “I AM” LAYER or KETHERIC TEMPLATE

The seventh and final layer is associated with the crown chakra, our ultimate connection with all that is. While the sixth layer is also higher consciousness, the seventh represents unity consciousness—the point where you and the Universe become one. It extends about three feet away from the body.

Negative expressions on this level result in feelings of superiority, isolation and separation from God, others and even the self. Conversely, divine expression will result in true bliss and serenity.

http://www.encyclopedia-of-religion.org/meridian.html

General Information on the Meridians

The entire human body, as well as bodies of animals and even plants, is run through by numerous canals, invisible to ordinary eyesight, that channel energies of various levels of subtlety around the body. These canals, called meridians (or nadi), were discovered and utilized in ancient Japanese and Chinese medicine.

The meridians are channels in which energy flows. They are sometimes referred to as “rivers of light” by healers. The treatment modality of acupuncture was originally developed by healers who could “see” the rivers of light and how the flowing relationships and blockages in the flow were related to health and disease. They created a “model” which explained the relationships  between the different channels and energy centers as they saw them. This is now known as the meridians and the law of five elements.

Because of inflammatory processes in the body tissues and improper nutrition meridians can lose their conductivity. Then lingering disorders of the organs deprived of proper energy supply may develop. Such diseases usually cannot be completely cured by drug therapy.  In such cases, acupunctural methods and Reiki influence through “biologically active points” (acupuncture  points) of the integument turn out to be efficient. These methods work because they restore conductivity of meridians by means of sending currents of energy through them.

Developing a higher state of energy involves two categories of action. One is stopping energy leaks and the other is collecting or connecting to new energy.  The Art of “Reiki” does both.

Reiki is a simple, natural and safe method of spiritual healing and self-improvement that everyone can use. It has been effective in helping virtually every known illness and malady and always creates a beneficial effect. It also works in conjunction with all other medical or therapeutic techniques to relieve side effects and promote recovery.

Its use is not dependent on one’s intellectual capacity or spiritual development and therefore is available to everyone. It has been successfully taught to thousands of people of all ages and backgrounds.

While Reiki is spiritual in nature, it is not a religion. It has no dogma, and there is nothing you must believe in order to learn and use Reiki. In fact, Reiki is not dependent on belief at all and will work whether you believe in it or not. Because Reiki comes from the Holy Spirit, many people find that using Reiki puts them more in touch with the experience of their religion rather  than having only an intellectual concept of it.

  A special thank you to those in the media, Oprah Winfrey and Dr. Oz, who are educating people about this alternative healing therapy.

And,

Welcome to Reiki!

  REIKI’s influences the body’s AURA, CHAKRA & MERIDIANS Reiki supports the body’s functions through its energy systems of the Aura, Chakras and Meridians. 

[greatestlcve]

Lexomil tablet Uses, Dosage, Side Effects, Precautions

Drug Online

lexomil tablet 6mg is Generic drug of the therapeutic class: Neurology – psychiatry active ingredients: Bromazepam

what is lexomil 6mg?

This medicine is recommended in the treatment of anxiety when it is accompanied by troublesome disorders, or in the prevention and / or treatment of manifestations related to alcohol withdrawal.

what is the generic name of lexomil

the generic name of lexomil is Bromazepam

What is the use of Lexotanil and indication ?

Symptomatic treatment of severe and / or disabling anxiety disorders.

Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal.

Lexomil Dosage

The use of bromazepam is not recommended in children, in the absence of study. In addition, the tablet is not a form suitable for children under 6 years (risk of mis-driving).

DOSE :

In all cases, treatment will be initiated at the lowest effective dose and the maximum dose will not be exceeded.

In current practice :

In adults , the beginning of treatment, the mean daily dose of BROMAZEPAM is 6 mg per day, spread most often as follows:

. 1/4 compressed-wand morning (1.5 mg)

. 1/4 compressed-wand at noon (1.5 mg)

. 1/2 tablet-baguette at night (3 mg).

It must then be adapted individually according to the therapeutic response.

– In psychiatry :

Depending on the severity of the anxiety to be treated: in ambulatory patients, the dosage is between 6 and 18 mg; in subjects whose severity of the anxiety syndrome requires hospitalization, it is possible to prescribe higher doses, 24 or even 36 mg per day.

– In children, the elderly, the renal or hepatic insufficiency : it is recommended to reduce the dosage, by half for example.

DURATION :

Treatment should be as short as possible. The indication will be reviewed regularly especially in the absence of symptoms. The overall duration of treatment should notexceed 8 to 12 weeks for the majority of patients, including the dose reduction period (see section cautionary statements and precautions for use).

In some cases, it may be necessary to prolong the treatment beyond the recommended periods. This requires accurate and repeated assessments of the patient’s condition.

– Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal : short treatment of the order of 8 to 10 days. 

Contraindications

Bromazepam hypersensitivity

Benzodiazepine hypersensitivity

Severe respiratory failure

Severe hepatic impairment

Myasthenia gravis

Sleep apnea syndrome

Child under 6

Galactose intolerance

Glucose malabsorption syndrome

Galactose malabsorption syndrome

Lactase deficiency

Alcohol consumption

Pregnancy

Feeding with milk

This medication should never be used in the following situations:

Known hypersensitivity to benzodiazepines, the active ingredient, or one of the other constituents,

Severe respiratory failure,

Severe acute or chronic liver failure (risk of developing hepatic encephalopathy)

Gravis,

 Sleep apnea syndrome.

How to store LEXOMIL 6 mg, four-break tablet?

Keep this medication out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the package after EXP. The expiration date refers to the last day of that month.

No special storage conditions.

Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

How it works ?

DERIVATIVES OF BENZODIAZEPINE.

ATC code: N05BA (anxiolytics).

(N: Central Nervous System).

– The bromazepam belongs to the class of benzodiazepines 1-4 and pharmacodynamic activity qualitatively similar to that of other compounds of this class

. muscle relaxant,

. anxiolytic

. sedative,

. hypnotic

. anticonvulsant,

. amnesic.

These effects are linked to a specific agonist action on a central receptor belonging to the complex “GABA-OMEGA macromolecular receptors”, also called BZ1 and BZ2 and modulating the opening of the chlorine channel.

Lexomil side effect

Description of adverse effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

They are related to the ingested dose and the individual sensitivity of the patient.

Neuro-psychiatric side effects (see Warnings): Not known

· Memory problems, which can occur at therapeutic doses, the risk increases in proportion to the dose,

· Depression

· Behavior disorders, changes in consciousness, irritability, aggression, agitation,

· Physical and mental dependence, even at therapeutic doses with withdrawal syndrome or rebound at discontinuation of treatment,

· Feelings of vertigo, headaches, difficulty coordinating certain movements,

· Confusion, sleepiness or alertness decline (especially in the elderly), insomnia, nightmares, tension,

· Changes in libido.

Dermal side effects: Not known

· Rash, with or without itching, urticaria.

Cardiac Undesirable Effects: Not known

· Heart failure, including cardiac arrest

Respiratory side effects: Not known

· Decreased respiratory capacity

Gastrointestinal side effects: Not known

· Nausea, vomiting, constipation

Adverse effects of kidney and urinary tract : Not known

· Unable to urinate

Ocular Adverse Reactions: Not known

· Double vision.

Adverse reactions of the immune system: Not known

· Allergies (such as swelling, redness of the skin), including severe allergic reactions (anaphylactic shock, angioedema)

General side effects: Not known

· Muscle weakness, fatigue

Treatment Complications (see Warnings): Not known

· Falls, fractures.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This also applies to any side effects that are not mentioned in this leaflet. You can also report side effects directly via the national reporting system:

National Agency for the Safety of Medicines and Health Products (ANSM) and the network of Regional Pharmacovigilance Centers –

Lexomil Interactions 

Pharmacodynamic interaction

Associations advised against

Lexomil and Alcohol

Alcohol enhancement of the sedative effect of benzodiazepines and the like. Impairment of alertness can make driving and using machines dangerous. Avoid taking alcoholic drinks and drugs containing alcohol.

Associations to consider

Other central nervous system depressants: Increased central depressant effect with morphine derivatives (analgesics, antitussives and substitution treatments other than buprenorphine); antipsychotics (neuroleptics); barbiturates; other anxiolytics; hypnotics; sedative antidepressants; sedative antihistamines H1; central antihypertensives; anticonvulsants; baclofen; Thalidomide.

Altered alertness can make driving dangerous and the use of machinery dangerous.

In addition, for morphine derivatives (analgesics, antitussives and substitution treatments), barbiturates:

increased risk of respiratory depression, which can be fatal in case of overdose, especially in the elderly.

Buprenorphine

Increased risk of respiratory depression, which can be fatal.

Carefully evaluate the benefit / risk ratio of this combination. Inform the patient of the need to respect the prescribed doses.

Clozapine

Increased risk of collapse with respiratory and / or cardiac arrest.

Pharmacokinetic interaction

Pharmacokinetic interactions may occur when bromazepam is administered with drugs that inhibit the CYP3A4 hepatic enzyme by increasing plasma levels of bromazepam.

Caution should be exercised when concomitant administration of bromazepam with potent CYP3A4 inhibitors (eg, azole antifungals, protease inhibitors, or certain macrolides) and a significant reduction in dosage should be considered. In the case of narcotic analgesics, a potentiation of euphoria may also occur, which may lead to increased psychic dependence.

Lexomil Warnings and Precautions

Warnings

This medicine contains lactose. Its use is contraindicated in patients with galactose intolerance, Lapp lactase deficiency or glucose or galactose malabsorption syndrome (hereditary diseases).

PHARMACOLOGICAL TOLERANCE:

The action of benzodiazepines and relatives may decrease gradually despite the use of the same dose in case of repeated administration for several weeks.

ADDICTION:

Any treatment with benzodiazepines and related drugs, especially with prolonged use, may result in a state of physical and mental dependence.

Various factors seem to favor the occurrence of dependence:

· Duration of treatment,

· Dose,

· History of other addictions: medication or not, including alcoholic.

Drug dependence may occur at therapeutic doses and / or in patients without individualized risk factors.

This state can lead to the cessation of treatment a withdrawal phenomenon.

Some symptoms are common and seemingly trivial: insomnia, headache, diarrhea, extreme anxiety, myalgia, tension, irritability, nervousness, confusion.

In severe cases the following symptoms may occur: hyperacusis, agitation or even confusional episode, paresthesia of the extremities, hypersensitivity to light, noise, and physical contact, depersonalization, derealization, hallucinatory phenomena, convulsions.

Withdrawal symptoms may occur within days of stopping treatment. For short-acting benzodiazepines, and especially if given at high doses, symptoms may even occur in the interval between two doses.

When using long-acting benzodiazepines, it is important to inform the patient that switching to a short-acting benzodiazepine may result in withdrawal symptoms.

The combination of several benzodiazepines may, regardless of the anxiolytic or hypnotic indication, increase the risk of drug dependence.

Cases of abuse have been reported.

REBOUND PHENOMENON / WEANING

This transient syndrome may manifest itself at the end of the treatment by the reappearance, in an accentuated form, of the symptoms of anxiety and insomnia which motivated the treatment with the benzodiazepines and allied ones.

 It may be accompanied by other reactions including mood changes, anxiety or sleep disturbances, and nervousness.

As the risk of rebound / weaning is higher after abrupt cessation of treatment, it is recommended to gradually reduce the dosage.

AMNESIA AND ALTERATIONS OF PSYCHOMOTIC FUNCTIONS

Anterograde amnesia and alterations in psychomotor function may occur within hours of taking the drug. Therefore, to reduce the risk, patients must be sure to sleep uninterrupted sleep for several hours after taking it. The effects of amnesia may be associated with inappropriate behavior.

PSYCHIATRIC AND PARADOXAL REACTIONS

In some subjects, benzodiazepines and related products may result in a syndrome associating to varying degrees an impairment of consciousness and behavioral and memory disorders may be observed:

· Worsening of insomnia, nightmares, agitation, nervousness,

· Delusions, hallucinations, confuso-oniric state, psychotic type symptoms,

· Disinhibition with impulsiveness,

· Euphoria, irritability,

· Anterograde amnesia,

· Suggestibility.

This syndrome may be accompanied by potentially dangerous disorders for the patient or for others, such as:

· Inappropriate behavior for the patient,

· Anger attacks, self- or hetero-aggressive behavior, especially if the entourage tries to hinder the patient’s activity,

· Automatic driving with post-event amnesia.

These events require the cessation of treatment. These reactions are more likely to occur in children and the elderly.

RISK OF ACCUMULATION

Benzodiazepines and related drugs (like all drugs) persist in the body for a period of about 5 half-lives.

In the elderly or with renal or hepatic insufficiency, the half-life may be considerably longer. When taken repeatedly, the drug or its metabolites reach the equilibrium plateau much later and at a much higher level. It is only after obtaining a balance plateau that it is possible to evaluate both the efficacy and the safety of the drug.

Dosage adjustment may be necessary (see section 4.2). The patient should be monitored regularly at the beginning of treatment in order to decrease the dosage and / or the frequency of administration and to prevent the occurrence of accumulation-related overdose.

SUBJECT AGE

Benzodiazepines and related products should be used with caution in the elderly, because of the risk of sedation and / or myorelaxant effect that may lead to falls, with often severe consequences in this population.

CONCOMITANT USE OF ALCOHOL / CNS DEPRESSANTS

Concomitant use of bromazepam with alcohol and / or CNS depressants should be avoided. This concomitant use may increase the clinical effects of bromazepam, including severe sedation and clinically relevant respiratory and / or cardiovascular depression.

Precautions for use

Great caution is recommended in case of a history of alcoholism or other addictions, whether medicated or not .

AT THE SUBJECT WITH A MAJOR DEPRESSIVE EPISODE

Benzodiazepines and related drugs should not be used alone to treat depression or anxiety associated with depression.

The latter may evolve on its own account with persistence or increase in suicidal risk.

 Bromazepam should therefore be used with caution and the duration of treatment should be limited in patients with signs and symptoms of depressive disorder or suicidal tendencies.

Benzodiazepines are not recommended for the first-line treatment of psychotic illnesses.

DURATION OF TREATMENT

The duration of treatment should be as short as possible and should not exceed 8 to 12 weeks, including the dose reduction phase.

 If it is necessary to prolong the treatment beyond this time, the patient’s condition must be re-evaluated. It is useful to inform the patient when initiating treatment that it will be of limited duration.

PROGRESSIVE STOPPING PROCEDURES FOR TREATMENT

They must be stated to the patient precisely.

In addition to the need for gradual decrease in doses, patients should be warned of the possibility of a rebound phenomenon, to minimize the anxiety that may arise from the symptoms related to this interruption, even progressive.

The patient should be warned of the possibly uncomfortable nature of this phase.

CHILD:

Even more than in adults, the benefit / risk ratio will be carefully evaluated and the duration of treatment as short as possible. No clinical studies have been conducted in children with bromazepam.

SUBJECT AGE, INSUFFICIENT RENAL AND INSUFFICIENT HEPATIC:

The risk of accumulation leads to a reduction in dosage, for example by half .

Benzodiazepines are contraindicated in patients with severe hepatic impairment (risk of encephalopathy).

INSUFFICIENT RESPIRATORY

In patients with respiratory insufficiency, the depressant effect of benzodiazepines and related substances should be taken into account (especially since anxiety and agitation may be signs of a call for a decompensation of the respiratory function which justifies the transition to intensive care unit). It is recommended to reduce the dose.

Drive and use machines

Prevent drivers of vehicles and machinery users from the risk of drowsiness, sedation, amnesia, impaired concentration and impaired muscle function.

The combination with other sedative drugs should be discouraged or taken into account when driving or using machines ( see Interactions ).

If sleep time is insufficient, the risk of impaired alertness is further increased. This effect is increased if the patient has consumed alcohol.

PREGNANCY / BREAST FEEDING / FERTILITY

lexomil and pregnancy

Many data from cohort studies have not revealed the occurrence of malformative effects during benzodiazepine exposure during the course of 1first  trimester of pregnancy. 

However, in some case-control epidemiological studies, an increase in the occurrence of cleft lip and palate has been observed with benzodiazepines. 

According to these data, the incidence of cleft lip and palate in newborns would be less than 2/1000 after exposure to benzodiazepines during pregnancy while the expected rate in the general population is 1/1000.

If benzodiazepines are taken in high doses at 2 nd and / or 3 rdtrimesters of pregnancy, a decrease in fetal active movements and a variability in fetal heart rate have been described. Treatment with benzodiazepines at the end of pregnancy, even at low doses, may be responsible in the newborn for signs of impregnation such as axial hypotonia, sucking disorders resulting in low weight gain. These signs are reversible, but may last 1-3 weeks depending on the half-life of the prescribed benzodiazepine. At high doses, respiratory depression or apnea, and hypothermia may occur in the newborn. In addition, a syndrome of neonatal withdrawal is possible, even in the absence of signs of impregnation. It is characterized in particular by hyperexcitability, agitation and tremulations of the newborn occurring at a distance from the delivery. The time of onset depends on the elimination half-life of the drug and may be important when it is long.

Given these data, as a precautionary measure, the use of bromazepam is not recommended during pregnancy for any term.

When prescribing bromazepam to a woman of childbearing age, she should be advised of the need to contact her doctor if a pregnancy is planned or started to re-assess the benefit of the treatment.

At the end of pregnancy, if it is really necessary to start treatment with bromazepam, avoid prescribing high doses and take into account, for the surveillance of the newborn, the effects described above.

Breastfeeding

Bromazepam passes into breast milk; therefore, the use of this medicine during breastfeeding is not recommended.

What should I do if I miss a dose?

Take the next dose at the usual time. Do not take a double dose to make up for the dose you forgot to take.

lexomil overdose

Immediately consult your doctor or pharmacist.

what happen If you stop taking LEXOMIL 6 mg, four-scored tablet?

Withdrawal and rebound phenomena (see Warnings).

If you have any further questions on the use of this medicine, ask your doctor or pharmacist for more information.

What is  Forms and Composition ?

FORMS and PRESENTATIONS

6 mg (white) quadrisecable baguette tablet:   Tube of 30.

Hospital model: Box of 100, in blister packs.

COMPOSITION

 p cpBromazepam (DCI)6 mg

Excipients: microcrystalline cellulose, lactose (100 mg / cp), talc, magnesium stearate.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Lexomil tablet Uses, Dosage, Side Effects, Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/35JnQcM via Edrug Online from Faculty of Medicine https://bit.ly/3iDVOmN via Internal Medicine

[thomasreedtn]

Metaphysical Meaning of UTI, Bladder and Kidney Problems

In a span of nine days, I just spoke with eight women about severe UTI or bladder infections. This topic is not unusual for Medical Intuitive sessions; however, that number of people in a short span of time definitely got my attention. I figured if so many people are contacting me about these issues at one time, then likely more “out there” are suffering in silence. This post is not limited to women, by the way. It just happened to be eight women I recently heard from about UTI and bladder issues.

As usual, I give my standard disclaimer: I am not a doctor or psychologist, not diagnosing or prescribing. Anything I share here is based on intuitive observation and/or experience. Medical Intuition is not meant to replace medical advice or support. I look at the energies of things on mental, emotional, spiritual, physical and other levels and report what I see. This post contains general information. Your specific situation might include other factors not mentioned here. If you would like a personal reading about your own symptoms or issues, that would require booking a private session. I do not offer mini-sessions via the comments section or email. I’m just posting this free material as a service since it seems to be “up” right now for a lot of people. 

Anger, UTI, Bladder and Kidney Infections

What’s pissing you off?

Seriously! Whenever I ask this question, people laugh at me, but anger — often what polite society considers inappropriate or ridiculous anger — is the emotional root of urinary tract, bladder and kidney burning, pain, infection and/or disease. I find that women especially have difficulty expressing anger, not wanting to hurt others. Instead, they turn that anger back on themselves in the form of intense pain and irritation “down there.” Ironically, shifting repressed irritation and pain from the emotional to the physical level tends to result in short tempers and increased irritation, thereby sending the energy right back to the emotional plane, where it demands attention.

Even if you find an effective herbal remedy or antibiotic this time, failing to address the deeper anger threatens to turn these UTI, bladder and kidney issues chronic. It also amplifies both the physical and emotional feelings, turning irritation to full on rage. Think of the forest fires currently ravaging the West Coast of the US, and also consider the massive flood damage from Hurricane Harvey, with Hurricanes Irma and Jose on the way. Fire and Water. Both have value, but both can also destroy: a fire can warm your house or burn it to the ground. Water can hydrate, renew and generate power, but it can also level everything in its path. In the US, we’ve reached a crisis level imbalance between Fire and Water — on both mundane and metaphysical levels.

The Sacral Chakra that holds the urinary tract, bladder, kidneys and sexual organs is our Water Center. It’s the site of our preferences, where our likes and our dislikes begin. It’s also the chakra of generation and regeneration — the seat of where and how we birth ourselves and our values into the world. The Water Center wants what it wants, regardless of what society tells us we “should” want. Repressing those deep longings and preferences doesn’t make them go away. It just forces them to express via indirect means. They can turn inward or outward, but when we fail to give adequate release in the appropriate chakra, they escape our conscious influence.

The Solar Plexus, just above this Sacral (2nd) Chakra, is our Fire Center. It affects digestion and includes the liver, whose primary emotion is frustration. Whenever we ignore deep, survival level urges of the soul, that repression creates frustration. (Sexual and spiritual energies are intimately linked.) With frustration, the liver gets overwhelmed by toxic emotions and physical toxins, and this overwhelm, in turn, creates even more frustration, which ricochet’s back to anger. Repressed Sacral Chakra and Solar Plexus energies create a negative feedback loop until one or the other (or both) of them bursts forth in destruction.

The Solar Plexus houses the ego, both negative and positive aspects of ego: asserting healthy boundaries, disregarding our own needs, or disrespecting others’ boundaries. Housing the stomach, it’s also the chakra most affected by disempowering lies and media spin. “I just can’t digest all this information.” “I’ve lost my center. I don’t even know how to react anymore.” “I don’t know how to trust my gut anymore.”

On the flip side, some people feel 100% certain of their convictions but can’t understand why they struggle with digestive issues. Eating the same thing every day (or only listening to one information stream) eventually results in deficiency that seems “necessary” for “balance.” “I can’t eat anything except these three foods” or “the other side has zero legitimate points, zip, none, nada.” Both statements evidence an imbalance of the Power Center.

When threatened, the Solar Plexus latches onto perspectives that make us feel significantly smaller or larger than we really are. “Who am I to shine?” comes just as much from ego imbalance as the most obvious narcissist steamrolling anyone in his or her way. False modesty, professional victim status, bullying, “snowflake triggers,” and energy vampirism are all signs of Solar Plexus imbalance. The anger, frustration and reactions such imbalances spawn needs to go somewhere. Quite often, that Fire energy gets squeezed back to the Water Center, creating burning sensations instead of healthy digestive fire. (For a discussion of what happens when unexpressed anger and frustration get squeezed up to the Heart Chakra, please see, “Overgiving, Resentment and Breast Cancer.”)

For the purposes of this article, we’re looking at the complex interplay between Fire and Water — as well as desire, creation, anger and frustration.

As Within, So Without

And for Empaths, as without, so within. Anyone tuned into Collective energies needs to exercise extra self-awareness and authenticity, or else any predisposition to a UTI, bladder infection or kidney issue will find the easiest routes to physical manifestation.

The most common cause of a UTI on the physical level is poor hygiene — wiping back to front, improper cleaning after sexual relations, or some kind of leakage that introduces fecal matter where it does not belong. On the metaphysical level, it’s taking that which has already served its purpose (i.e. digested food whose remains have now become unhealthy) and introducing that which no longer serves into our Water Center of preferences, aversions and deep longing.

On the macro level, think about groundwater contamination by runoff from factory farms. I in no way support factory farming, but proper management of that waste could serve to nourish the land as compost. Improper management of waste poisons the Water Center. When First Chakra (colon) infiltrates Second/Sacral Chakra, we get the psychic equivalent of contaminated groundwater. First Chakra is primarily concerned with foundations and security. When money or security fears overwhelm the Water Center’s natural longings and predispositions, that water becomes undrinkable without some kind of treatment or purification.

Empaths in particular struggle to discern their own desires apart from childhood programming or others’ expectations. Good energy hygiene means regularly wiping off others’ energies and expectations, in order to maintain your own natural balance. Do this from “front to back,” in other words, start with yourself rather than dragging in the expectations. Don’t try to clear while also dragging in the old fears and expectations. There are many ways to practice good energy hygiene; find what works best for you before those poopy energies disrupt your system in painful, persistent ways.

One of the easiest physical remedies at the first signs of a UTI is simply to drink more water. Flood the Water Center with its natural element. Flush out toxins until you’re “in the flow.” On the metaphysical level, this means flooding yourself with experiences, sounds, scents, and sights that align with and nourish your preferences. Treat yourself to some version of a deep longing. Trust your intuition, which arises from these longings.

To the extent you can, minimize any ongoing irritations. On the physical level, don’t eat spicy foods, and avoid coffee and alcohol. Excuse yourself and flee toxic situations, turn off the television, fix that tricky doorknob that drives you crazy. Addressing minor irritations helps shift your energy to tackle larger issues that take more time to change. Flooding yourself with what you do want and flushing out what you don’t want goes a long way toward preventing the more serious bladder or kidney infections. It also greatly aids in clarifying those age old questions, “Who am I and what do I want to do with myself?”

If you don’t think you’re an Empath but you get frequent UTI’s, bladder infections or kidney stones, you’ll want to pick up Dr. Judith Orloff’s excellent “The Empath’s Survival Guide,” which provides lots of self-tests, tools and strategies, especially helpful for people who have no idea what I’m talking about here!

Get Creative

The Sacral Chakra also houses the sexual organs, including the womb — both metaphysical and (in the case of women) physical. Whether or not we choose to bring human children into the world, we all have “babies.” Any creative project we bring forth incubates for some time in the Water Center, just as all life proceeds from the Sea, Cosmic or otherwise.

If you’d like to balance this area long term, you’ll need to harness Desire and use it to direct your creativity. We are all creative, no matter what your high school art teacher might have told you. Find a hobby or creative pursuit and let yourself play. What little things bring you joy? What lifts you into ecstacy? Dance? Pottery? Baking? Painting? Allow creativity to flow through you. Turn that “inappropriate” anger into something gorgeous. Or poignant. It doesn’t matter. Just take that energy and redirect it. Encourage that creative Water Center to flow instead of burn.

“The truth will set you free. But first, it will piss you off.” ~ Gloria Steinem

You will stop feeling so pissy when you move towards inner truth and freedom.

Blessings on the journey!

    from Thomas Reed https://laurabruno.wordpress.com/2017/09/06/metaphysical-meaning-of-uti-bladder-and-kidney-problems/

[thesittingduck]

Lexomil tablet Uses, Dosage, Side Effects, Precautions

Drug Online

lexomil tablet 6mg is Generic drug of the therapeutic class: Neurology – psychiatry active ingredients: Bromazepam

what is lexomil 6mg?

This medicine is recommended in the treatment of anxiety when it is accompanied by troublesome disorders, or in the prevention and / or treatment of manifestations related to alcohol withdrawal.

what is the generic name of lexomil

the generic name of lexomil is Bromazepam

What is the use of Lexotanil and indication ?

Symptomatic treatment of severe and / or disabling anxiety disorders.

Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal.

Lexomil Dosage

The use of bromazepam is not recommended in children, in the absence of study. In addition, the tablet is not a form suitable for children under 6 years (risk of mis-driving).

DOSE :

In all cases, treatment will be initiated at the lowest effective dose and the maximum dose will not be exceeded.

In current practice :

In adults , the beginning of treatment, the mean daily dose of BROMAZEPAM is 6 mg per day, spread most often as follows:

. 1/4 compressed-wand morning (1.5 mg)

. 1/4 compressed-wand at noon (1.5 mg)

. 1/2 tablet-baguette at night (3 mg).

It must then be adapted individually according to the therapeutic response.

– In psychiatry :

Depending on the severity of the anxiety to be treated: in ambulatory patients, the dosage is between 6 and 18 mg; in subjects whose severity of the anxiety syndrome requires hospitalization, it is possible to prescribe higher doses, 24 or even 36 mg per day.

– In children, the elderly, the renal or hepatic insufficiency : it is recommended to reduce the dosage, by half for example.

DURATION :

Treatment should be as short as possible. The indication will be reviewed regularly especially in the absence of symptoms. The overall duration of treatment should notexceed 8 to 12 weeks for the majority of patients, including the dose reduction period (see section cautionary statements and precautions for use).

In some cases, it may be necessary to prolong the treatment beyond the recommended periods. This requires accurate and repeated assessments of the patient’s condition.

– Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal : short treatment of the order of 8 to 10 days. 

Contraindications

Bromazepam hypersensitivity

Benzodiazepine hypersensitivity

Severe respiratory failure

Severe hepatic impairment

Myasthenia gravis

Sleep apnea syndrome

Child under 6

Galactose intolerance

Glucose malabsorption syndrome

Galactose malabsorption syndrome

Lactase deficiency

Alcohol consumption

Pregnancy

Feeding with milk

This medication should never be used in the following situations:

Known hypersensitivity to benzodiazepines, the active ingredient, or one of the other constituents,

Severe respiratory failure,

Severe acute or chronic liver failure (risk of developing hepatic encephalopathy)

Gravis,

 Sleep apnea syndrome.

How to store LEXOMIL 6 mg, four-break tablet?

Keep this medication out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the package after EXP. The expiration date refers to the last day of that month.

No special storage conditions.

Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

How it works ?

DERIVATIVES OF BENZODIAZEPINE.

ATC code: N05BA (anxiolytics).

(N: Central Nervous System).

– The bromazepam belongs to the class of benzodiazepines 1-4 and pharmacodynamic activity qualitatively similar to that of other compounds of this class

. muscle relaxant,

. anxiolytic

. sedative,

. hypnotic

. anticonvulsant,

. amnesic.

These effects are linked to a specific agonist action on a central receptor belonging to the complex “GABA-OMEGA macromolecular receptors”, also called BZ1 and BZ2 and modulating the opening of the chlorine channel.

Lexomil side effect

Description of adverse effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

They are related to the ingested dose and the individual sensitivity of the patient.

Neuro-psychiatric side effects (see Warnings): Not known

· Memory problems, which can occur at therapeutic doses, the risk increases in proportion to the dose,

· Depression

· Behavior disorders, changes in consciousness, irritability, aggression, agitation,

· Physical and mental dependence, even at therapeutic doses with withdrawal syndrome or rebound at discontinuation of treatment,

· Feelings of vertigo, headaches, difficulty coordinating certain movements,

· Confusion, sleepiness or alertness decline (especially in the elderly), insomnia, nightmares, tension,

· Changes in libido.

Dermal side effects: Not known

· Rash, with or without itching, urticaria.

Cardiac Undesirable Effects: Not known

· Heart failure, including cardiac arrest

Respiratory side effects: Not known

· Decreased respiratory capacity

Gastrointestinal side effects: Not known

· Nausea, vomiting, constipation

Adverse effects of kidney and urinary tract : Not known

· Unable to urinate

Ocular Adverse Reactions: Not known

· Double vision.

Adverse reactions of the immune system: Not known

· Allergies (such as swelling, redness of the skin), including severe allergic reactions (anaphylactic shock, angioedema)

General side effects: Not known

· Muscle weakness, fatigue

Treatment Complications (see Warnings): Not known

· Falls, fractures.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This also applies to any side effects that are not mentioned in this leaflet. You can also report side effects directly via the national reporting system:

National Agency for the Safety of Medicines and Health Products (ANSM) and the network of Regional Pharmacovigilance Centers –

Lexomil Interactions 

Pharmacodynamic interaction

Associations advised against

Lexomil and Alcohol

Alcohol enhancement of the sedative effect of benzodiazepines and the like. Impairment of alertness can make driving and using machines dangerous. Avoid taking alcoholic drinks and drugs containing alcohol.

Associations to consider

Other central nervous system depressants: Increased central depressant effect with morphine derivatives (analgesics, antitussives and substitution treatments other than buprenorphine); antipsychotics (neuroleptics); barbiturates; other anxiolytics; hypnotics; sedative antidepressants; sedative antihistamines H1; central antihypertensives; anticonvulsants; baclofen; Thalidomide.

Altered alertness can make driving dangerous and the use of machinery dangerous.

In addition, for morphine derivatives (analgesics, antitussives and substitution treatments), barbiturates:

increased risk of respiratory depression, which can be fatal in case of overdose, especially in the elderly.

Buprenorphine

Increased risk of respiratory depression, which can be fatal.

Carefully evaluate the benefit / risk ratio of this combination. Inform the patient of the need to respect the prescribed doses.

Clozapine

Increased risk of collapse with respiratory and / or cardiac arrest.

Pharmacokinetic interaction

Pharmacokinetic interactions may occur when bromazepam is administered with drugs that inhibit the CYP3A4 hepatic enzyme by increasing plasma levels of bromazepam.

Caution should be exercised when concomitant administration of bromazepam with potent CYP3A4 inhibitors (eg, azole antifungals, protease inhibitors, or certain macrolides) and a significant reduction in dosage should be considered. In the case of narcotic analgesics, a potentiation of euphoria may also occur, which may lead to increased psychic dependence.

Lexomil Warnings and Precautions

Warnings

This medicine contains lactose. Its use is contraindicated in patients with galactose intolerance, Lapp lactase deficiency or glucose or galactose malabsorption syndrome (hereditary diseases).

PHARMACOLOGICAL TOLERANCE:

The action of benzodiazepines and relatives may decrease gradually despite the use of the same dose in case of repeated administration for several weeks.

ADDICTION:

Any treatment with benzodiazepines and related drugs, especially with prolonged use, may result in a state of physical and mental dependence.

Various factors seem to favor the occurrence of dependence:

· Duration of treatment,

· Dose,

· History of other addictions: medication or not, including alcoholic.

Drug dependence may occur at therapeutic doses and / or in patients without individualized risk factors.

This state can lead to the cessation of treatment a withdrawal phenomenon.

Some symptoms are common and seemingly trivial: insomnia, headache, diarrhea, extreme anxiety, myalgia, tension, irritability, nervousness, confusion.

In severe cases the following symptoms may occur: hyperacusis, agitation or even confusional episode, paresthesia of the extremities, hypersensitivity to light, noise, and physical contact, depersonalization, derealization, hallucinatory phenomena, convulsions.

Withdrawal symptoms may occur within days of stopping treatment. For short-acting benzodiazepines, and especially if given at high doses, symptoms may even occur in the interval between two doses.

When using long-acting benzodiazepines, it is important to inform the patient that switching to a short-acting benzodiazepine may result in withdrawal symptoms.

The combination of several benzodiazepines may, regardless of the anxiolytic or hypnotic indication, increase the risk of drug dependence.

Cases of abuse have been reported.

REBOUND PHENOMENON / WEANING

This transient syndrome may manifest itself at the end of the treatment by the reappearance, in an accentuated form, of the symptoms of anxiety and insomnia which motivated the treatment with the benzodiazepines and allied ones.

 It may be accompanied by other reactions including mood changes, anxiety or sleep disturbances, and nervousness.

As the risk of rebound / weaning is higher after abrupt cessation of treatment, it is recommended to gradually reduce the dosage.

AMNESIA AND ALTERATIONS OF PSYCHOMOTIC FUNCTIONS

Anterograde amnesia and alterations in psychomotor function may occur within hours of taking the drug. Therefore, to reduce the risk, patients must be sure to sleep uninterrupted sleep for several hours after taking it. The effects of amnesia may be associated with inappropriate behavior.

PSYCHIATRIC AND PARADOXAL REACTIONS

In some subjects, benzodiazepines and related products may result in a syndrome associating to varying degrees an impairment of consciousness and behavioral and memory disorders may be observed:

· Worsening of insomnia, nightmares, agitation, nervousness,

· Delusions, hallucinations, confuso-oniric state, psychotic type symptoms,

· Disinhibition with impulsiveness,

· Euphoria, irritability,

· Anterograde amnesia,

· Suggestibility.

This syndrome may be accompanied by potentially dangerous disorders for the patient or for others, such as:

· Inappropriate behavior for the patient,

· Anger attacks, self- or hetero-aggressive behavior, especially if the entourage tries to hinder the patient’s activity,

· Automatic driving with post-event amnesia.

These events require the cessation of treatment. These reactions are more likely to occur in children and the elderly.

RISK OF ACCUMULATION

Benzodiazepines and related drugs (like all drugs) persist in the body for a period of about 5 half-lives.

In the elderly or with renal or hepatic insufficiency, the half-life may be considerably longer. When taken repeatedly, the drug or its metabolites reach the equilibrium plateau much later and at a much higher level. It is only after obtaining a balance plateau that it is possible to evaluate both the efficacy and the safety of the drug.

Dosage adjustment may be necessary (see section 4.2). The patient should be monitored regularly at the beginning of treatment in order to decrease the dosage and / or the frequency of administration and to prevent the occurrence of accumulation-related overdose.

SUBJECT AGE

Benzodiazepines and related products should be used with caution in the elderly, because of the risk of sedation and / or myorelaxant effect that may lead to falls, with often severe consequences in this population.

CONCOMITANT USE OF ALCOHOL / CNS DEPRESSANTS

Concomitant use of bromazepam with alcohol and / or CNS depressants should be avoided. This concomitant use may increase the clinical effects of bromazepam, including severe sedation and clinically relevant respiratory and / or cardiovascular depression.

Precautions for use

Great caution is recommended in case of a history of alcoholism or other addictions, whether medicated or not .

AT THE SUBJECT WITH A MAJOR DEPRESSIVE EPISODE

Benzodiazepines and related drugs should not be used alone to treat depression or anxiety associated with depression.

The latter may evolve on its own account with persistence or increase in suicidal risk.

 Bromazepam should therefore be used with caution and the duration of treatment should be limited in patients with signs and symptoms of depressive disorder or suicidal tendencies.

Benzodiazepines are not recommended for the first-line treatment of psychotic illnesses.

DURATION OF TREATMENT

The duration of treatment should be as short as possible and should not exceed 8 to 12 weeks, including the dose reduction phase.

 If it is necessary to prolong the treatment beyond this time, the patient’s condition must be re-evaluated. It is useful to inform the patient when initiating treatment that it will be of limited duration.

PROGRESSIVE STOPPING PROCEDURES FOR TREATMENT

They must be stated to the patient precisely.

In addition to the need for gradual decrease in doses, patients should be warned of the possibility of a rebound phenomenon, to minimize the anxiety that may arise from the symptoms related to this interruption, even progressive.

The patient should be warned of the possibly uncomfortable nature of this phase.

CHILD:

Even more than in adults, the benefit / risk ratio will be carefully evaluated and the duration of treatment as short as possible. No clinical studies have been conducted in children with bromazepam.

SUBJECT AGE, INSUFFICIENT RENAL AND INSUFFICIENT HEPATIC:

The risk of accumulation leads to a reduction in dosage, for example by half .

Benzodiazepines are contraindicated in patients with severe hepatic impairment (risk of encephalopathy).

INSUFFICIENT RESPIRATORY

In patients with respiratory insufficiency, the depressant effect of benzodiazepines and related substances should be taken into account (especially since anxiety and agitation may be signs of a call for a decompensation of the respiratory function which justifies the transition to intensive care unit). It is recommended to reduce the dose.

Drive and use machines

Prevent drivers of vehicles and machinery users from the risk of drowsiness, sedation, amnesia, impaired concentration and impaired muscle function.

The combination with other sedative drugs should be discouraged or taken into account when driving or using machines ( see Interactions ).

If sleep time is insufficient, the risk of impaired alertness is further increased. This effect is increased if the patient has consumed alcohol.

PREGNANCY / BREAST FEEDING / FERTILITY

lexomil and pregnancy

Many data from cohort studies have not revealed the occurrence of malformative effects during benzodiazepine exposure during the course of 1first  trimester of pregnancy. 

However, in some case-control epidemiological studies, an increase in the occurrence of cleft lip and palate has been observed with benzodiazepines. 

According to these data, the incidence of cleft lip and palate in newborns would be less than 2/1000 after exposure to benzodiazepines during pregnancy while the expected rate in the general population is 1/1000.

If benzodiazepines are taken in high doses at 2 nd and / or 3 rdtrimesters of pregnancy, a decrease in fetal active movements and a variability in fetal heart rate have been described. Treatment with benzodiazepines at the end of pregnancy, even at low doses, may be responsible in the newborn for signs of impregnation such as axial hypotonia, sucking disorders resulting in low weight gain. These signs are reversible, but may last 1-3 weeks depending on the half-life of the prescribed benzodiazepine. At high doses, respiratory depression or apnea, and hypothermia may occur in the newborn. In addition, a syndrome of neonatal withdrawal is possible, even in the absence of signs of impregnation. It is characterized in particular by hyperexcitability, agitation and tremulations of the newborn occurring at a distance from the delivery. The time of onset depends on the elimination half-life of the drug and may be important when it is long.

Given these data, as a precautionary measure, the use of bromazepam is not recommended during pregnancy for any term.

When prescribing bromazepam to a woman of childbearing age, she should be advised of the need to contact her doctor if a pregnancy is planned or started to re-assess the benefit of the treatment.

At the end of pregnancy, if it is really necessary to start treatment with bromazepam, avoid prescribing high doses and take into account, for the surveillance of the newborn, the effects described above.

Breastfeeding

Bromazepam passes into breast milk; therefore, the use of this medicine during breastfeeding is not recommended.

What should I do if I miss a dose?

Take the next dose at the usual time. Do not take a double dose to make up for the dose you forgot to take.

lexomil overdose

Immediately consult your doctor or pharmacist.

what happen If you stop taking LEXOMIL 6 mg, four-scored tablet?

Withdrawal and rebound phenomena (see Warnings).

If you have any further questions on the use of this medicine, ask your doctor or pharmacist for more information.

What is  Forms and Composition ?

FORMS and PRESENTATIONS

6 mg (white) quadrisecable baguette tablet:   Tube of 30.

Hospital model: Box of 100, in blister packs.

COMPOSITION

  p cp Bromazepam (DCI) 6 mg

Excipients: microcrystalline cellulose, lactose (100 mg / cp), talc, magnesium stearate.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Lexomil tablet Uses, Dosage, Side Effects, Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/35JnQcM via Edrug Online from faculty of medicine https://bit.ly/32BhBpo via Faculty of Medicine

[colinfitzpatrick]

Lexomil tablet Uses, Dosage, Side Effects, Precautions

Drug Online

lexomil tablet 6mg is Generic drug of the therapeutic class: Neurology – psychiatry active ingredients: Bromazepam

what is lexomil 6mg?

This medicine is recommended in the treatment of anxiety when it is accompanied by troublesome disorders, or in the prevention and / or treatment of manifestations related to alcohol withdrawal.

what is the generic name of lexomil

the generic name of lexomil is Bromazepam

What is the use of Lexotanil and indication ?

Symptomatic treatment of severe and / or disabling anxiety disorders.

Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal.

Lexomil Dosage

The use of bromazepam is not recommended in children, in the absence of study. In addition, the tablet is not a form suitable for children under 6 years (risk of mis-driving).

DOSE :

In all cases, treatment will be initiated at the lowest effective dose and the maximum dose will not be exceeded.

In current practice :

In adults , the beginning of treatment, the mean daily dose of BROMAZEPAM is 6 mg per day, spread most often as follows:

. 1/4 compressed-wand morning (1.5 mg)

. 1/4 compressed-wand at noon (1.5 mg)

. 1/2 tablet-baguette at night (3 mg).

It must then be adapted individually according to the therapeutic response.

– In psychiatry :

Depending on the severity of the anxiety to be treated: in ambulatory patients, the dosage is between 6 and 18 mg; in subjects whose severity of the anxiety syndrome requires hospitalization, it is possible to prescribe higher doses, 24 or even 36 mg per day.

– In children, the elderly, the renal or hepatic insufficiency : it is recommended to reduce the dosage, by half for example.

DURATION :

Treatment should be as short as possible. The indication will be reviewed regularly especially in the absence of symptoms. The overall duration of treatment should notexceed 8 to 12 weeks for the majority of patients, including the dose reduction period (see section cautionary statements and precautions for use).

In some cases, it may be necessary to prolong the treatment beyond the recommended periods. This requires accurate and repeated assessments of the patient’s condition.

– Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal : short treatment of the order of 8 to 10 days. 

Contraindications

Bromazepam hypersensitivity

Benzodiazepine hypersensitivity

Severe respiratory failure

Severe hepatic impairment

Myasthenia gravis

Sleep apnea syndrome

Child under 6

Galactose intolerance

Glucose malabsorption syndrome

Galactose malabsorption syndrome

Lactase deficiency

Alcohol consumption

Pregnancy

Feeding with milk

This medication should never be used in the following situations:

Known hypersensitivity to benzodiazepines, the active ingredient, or one of the other constituents,

Severe respiratory failure,

Severe acute or chronic liver failure (risk of developing hepatic encephalopathy)

Gravis,

 Sleep apnea syndrome.

How to store LEXOMIL 6 mg, four-break tablet?

Keep this medication out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the package after EXP. The expiration date refers to the last day of that month.

No special storage conditions.

Do not throw away any medicines via a wastewater treatment plant or with household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

How it works ?

DERIVATIVES OF BENZODIAZEPINE.

ATC code: N05BA (anxiolytics).

(N: Central Nervous System).

– The bromazepam belongs to the class of benzodiazepines 1-4 and pharmacodynamic activity qualitatively similar to that of other compounds of this class

. muscle relaxant,

. anxiolytic

. sedative,

. hypnotic

. anticonvulsant,

. amnesic.

These effects are linked to a specific agonist action on a central receptor belonging to the complex “GABA-OMEGA macromolecular receptors”, also called BZ1 and BZ2 and modulating the opening of the chlorine channel.

Lexomil side effect

Description of adverse effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

They are related to the ingested dose and the individual sensitivity of the patient.

Neuro-psychiatric side effects (see Warnings): Not known

· Memory problems, which can occur at therapeutic doses, the risk increases in proportion to the dose,

· Depression

· Behavior disorders, changes in consciousness, irritability, aggression, agitation,

· Physical and mental dependence, even at therapeutic doses with withdrawal syndrome or rebound at discontinuation of treatment,

· Feelings of vertigo, headaches, difficulty coordinating certain movements,

· Confusion, sleepiness or alertness decline (especially in the elderly), insomnia, nightmares, tension,

· Changes in libido.

Dermal side effects: Not known

· Rash, with or without itching, urticaria.

Cardiac Undesirable Effects: Not known

· Heart failure, including cardiac arrest

Respiratory side effects: Not known

· Decreased respiratory capacity

Gastrointestinal side effects: Not known

· Nausea, vomiting, constipation

Adverse effects of kidney and urinary tract : Not known

· Unable to urinate

Ocular Adverse Reactions: Not known

· Double vision.

Adverse reactions of the immune system: Not known

· Allergies (such as swelling, redness of the skin), including severe allergic reactions (anaphylactic shock, angioedema)

General side effects: Not known

· Muscle weakness, fatigue

Treatment Complications (see Warnings): Not known

· Falls, fractures.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This also applies to any side effects that are not mentioned in this leaflet. You can also report side effects directly via the national reporting system:

National Agency for the Safety of Medicines and Health Products (ANSM) and the network of Regional Pharmacovigilance Centers –

Lexomil Interactions 

Pharmacodynamic interaction

Associations advised against

Lexomil and Alcohol

Alcohol enhancement of the sedative effect of benzodiazepines and the like. Impairment of alertness can make driving and using machines dangerous. Avoid taking alcoholic drinks and drugs containing alcohol.

Associations to consider

Other central nervous system depressants: Increased central depressant effect with morphine derivatives (analgesics, antitussives and substitution treatments other than buprenorphine); antipsychotics (neuroleptics); barbiturates; other anxiolytics; hypnotics; sedative antidepressants; sedative antihistamines H1; central antihypertensives; anticonvulsants; baclofen; Thalidomide.

Altered alertness can make driving dangerous and the use of machinery dangerous.

In addition, for morphine derivatives (analgesics, antitussives and substitution treatments), barbiturates:

increased risk of respiratory depression, which can be fatal in case of overdose, especially in the elderly.

Buprenorphine

Increased risk of respiratory depression, which can be fatal.

Carefully evaluate the benefit / risk ratio of this combination. Inform the patient of the need to respect the prescribed doses.

Clozapine

Increased risk of collapse with respiratory and / or cardiac arrest.

Pharmacokinetic interaction

Pharmacokinetic interactions may occur when bromazepam is administered with drugs that inhibit the CYP3A4 hepatic enzyme by increasing plasma levels of bromazepam.

Caution should be exercised when concomitant administration of bromazepam with potent CYP3A4 inhibitors (eg, azole antifungals, protease inhibitors, or certain macrolides) and a significant reduction in dosage should be considered. In the case of narcotic analgesics, a potentiation of euphoria may also occur, which may lead to increased psychic dependence.

Lexomil Warnings and Precautions

Warnings

This medicine contains lactose. Its use is contraindicated in patients with galactose intolerance, Lapp lactase deficiency or glucose or galactose malabsorption syndrome (hereditary diseases).

PHARMACOLOGICAL TOLERANCE:

The action of benzodiazepines and relatives may decrease gradually despite the use of the same dose in case of repeated administration for several weeks.

ADDICTION:

Any treatment with benzodiazepines and related drugs, especially with prolonged use, may result in a state of physical and mental dependence.

Various factors seem to favor the occurrence of dependence:

· Duration of treatment,

· Dose,

· History of other addictions: medication or not, including alcoholic.

Drug dependence may occur at therapeutic doses and / or in patients without individualized risk factors.

This state can lead to the cessation of treatment a withdrawal phenomenon.

Some symptoms are common and seemingly trivial: insomnia, headache, diarrhea, extreme anxiety, myalgia, tension, irritability, nervousness, confusion.

In severe cases the following symptoms may occur: hyperacusis, agitation or even confusional episode, paresthesia of the extremities, hypersensitivity to light, noise, and physical contact, depersonalization, derealization, hallucinatory phenomena, convulsions.

Withdrawal symptoms may occur within days of stopping treatment. For short-acting benzodiazepines, and especially if given at high doses, symptoms may even occur in the interval between two doses.

When using long-acting benzodiazepines, it is important to inform the patient that switching to a short-acting benzodiazepine may result in withdrawal symptoms.

The combination of several benzodiazepines may, regardless of the anxiolytic or hypnotic indication, increase the risk of drug dependence.

Cases of abuse have been reported.

REBOUND PHENOMENON / WEANING

This transient syndrome may manifest itself at the end of the treatment by the reappearance, in an accentuated form, of the symptoms of anxiety and insomnia which motivated the treatment with the benzodiazepines and allied ones.

 It may be accompanied by other reactions including mood changes, anxiety or sleep disturbances, and nervousness.

As the risk of rebound / weaning is higher after abrupt cessation of treatment, it is recommended to gradually reduce the dosage.

AMNESIA AND ALTERATIONS OF PSYCHOMOTIC FUNCTIONS

Anterograde amnesia and alterations in psychomotor function may occur within hours of taking the drug. Therefore, to reduce the risk, patients must be sure to sleep uninterrupted sleep for several hours after taking it. The effects of amnesia may be associated with inappropriate behavior.

PSYCHIATRIC AND PARADOXAL REACTIONS

In some subjects, benzodiazepines and related products may result in a syndrome associating to varying degrees an impairment of consciousness and behavioral and memory disorders may be observed:

· Worsening of insomnia, nightmares, agitation, nervousness,

· Delusions, hallucinations, confuso-oniric state, psychotic type symptoms,

· Disinhibition with impulsiveness,

· Euphoria, irritability,

· Anterograde amnesia,

· Suggestibility.

This syndrome may be accompanied by potentially dangerous disorders for the patient or for others, such as:

· Inappropriate behavior for the patient,

· Anger attacks, self- or hetero-aggressive behavior, especially if the entourage tries to hinder the patient’s activity,

· Automatic driving with post-event amnesia.

These events require the cessation of treatment. These reactions are more likely to occur in children and the elderly.

RISK OF ACCUMULATION

Benzodiazepines and related drugs (like all drugs) persist in the body for a period of about 5 half-lives.

In the elderly or with renal or hepatic insufficiency, the half-life may be considerably longer. When taken repeatedly, the drug or its metabolites reach the equilibrium plateau much later and at a much higher level. It is only after obtaining a balance plateau that it is possible to evaluate both the efficacy and the safety of the drug.

Dosage adjustment may be necessary (see section 4.2). The patient should be monitored regularly at the beginning of treatment in order to decrease the dosage and / or the frequency of administration and to prevent the occurrence of accumulation-related overdose.

SUBJECT AGE

Benzodiazepines and related products should be used with caution in the elderly, because of the risk of sedation and / or myorelaxant effect that may lead to falls, with often severe consequences in this population.

CONCOMITANT USE OF ALCOHOL / CNS DEPRESSANTS

Concomitant use of bromazepam with alcohol and / or CNS depressants should be avoided. This concomitant use may increase the clinical effects of bromazepam, including severe sedation and clinically relevant respiratory and / or cardiovascular depression.

Precautions for use

Great caution is recommended in case of a history of alcoholism or other addictions, whether medicated or not .

AT THE SUBJECT WITH A MAJOR DEPRESSIVE EPISODE

Benzodiazepines and related drugs should not be used alone to treat depression or anxiety associated with depression.

The latter may evolve on its own account with persistence or increase in suicidal risk.

 Bromazepam should therefore be used with caution and the duration of treatment should be limited in patients with signs and symptoms of depressive disorder or suicidal tendencies.

Benzodiazepines are not recommended for the first-line treatment of psychotic illnesses.

DURATION OF TREATMENT

The duration of treatment should be as short as possible and should not exceed 8 to 12 weeks, including the dose reduction phase.

 If it is necessary to prolong the treatment beyond this time, the patient’s condition must be re-evaluated. It is useful to inform the patient when initiating treatment that it will be of limited duration.

PROGRESSIVE STOPPING PROCEDURES FOR TREATMENT

They must be stated to the patient precisely.

In addition to the need for gradual decrease in doses, patients should be warned of the possibility of a rebound phenomenon, to minimize the anxiety that may arise from the symptoms related to this interruption, even progressive.

The patient should be warned of the possibly uncomfortable nature of this phase.

CHILD:

Even more than in adults, the benefit / risk ratio will be carefully evaluated and the duration of treatment as short as possible. No clinical studies have been conducted in children with bromazepam.

SUBJECT AGE, INSUFFICIENT RENAL AND INSUFFICIENT HEPATIC:

The risk of accumulation leads to a reduction in dosage, for example by half .

Benzodiazepines are contraindicated in patients with severe hepatic impairment (risk of encephalopathy).

INSUFFICIENT RESPIRATORY

In patients with respiratory insufficiency, the depressant effect of benzodiazepines and related substances should be taken into account (especially since anxiety and agitation may be signs of a call for a decompensation of the respiratory function which justifies the transition to intensive care unit). It is recommended to reduce the dose.

Drive and use machines

Prevent drivers of vehicles and machinery users from the risk of drowsiness, sedation, amnesia, impaired concentration and impaired muscle function.

The combination with other sedative drugs should be discouraged or taken into account when driving or using machines ( see Interactions ).

If sleep time is insufficient, the risk of impaired alertness is further increased. This effect is increased if the patient has consumed alcohol.

PREGNANCY / BREAST FEEDING / FERTILITY

lexomil and pregnancy

Many data from cohort studies have not revealed the occurrence of malformative effects during benzodiazepine exposure during the course of 1first  trimester of pregnancy. 

However, in some case-control epidemiological studies, an increase in the occurrence of cleft lip and palate has been observed with benzodiazepines. 

According to these data, the incidence of cleft lip and palate in newborns would be less than 2/1000 after exposure to benzodiazepines during pregnancy while the expected rate in the general population is 1/1000.

If benzodiazepines are taken in high doses at 2 nd and / or 3 rdtrimesters of pregnancy, a decrease in fetal active movements and a variability in fetal heart rate have been described. Treatment with benzodiazepines at the end of pregnancy, even at low doses, may be responsible in the newborn for signs of impregnation such as axial hypotonia, sucking disorders resulting in low weight gain. These signs are reversible, but may last 1-3 weeks depending on the half-life of the prescribed benzodiazepine. At high doses, respiratory depression or apnea, and hypothermia may occur in the newborn. In addition, a syndrome of neonatal withdrawal is possible, even in the absence of signs of impregnation. It is characterized in particular by hyperexcitability, agitation and tremulations of the newborn occurring at a distance from the delivery. The time of onset depends on the elimination half-life of the drug and may be important when it is long.

Given these data, as a precautionary measure, the use of bromazepam is not recommended during pregnancy for any term.

When prescribing bromazepam to a woman of childbearing age, she should be advised of the need to contact her doctor if a pregnancy is planned or started to re-assess the benefit of the treatment.

At the end of pregnancy, if it is really necessary to start treatment with bromazepam, avoid prescribing high doses and take into account, for the surveillance of the newborn, the effects described above.

Breastfeeding

Bromazepam passes into breast milk; therefore, the use of this medicine during breastfeeding is not recommended.

What should I do if I miss a dose?

Take the next dose at the usual time. Do not take a double dose to make up for the dose you forgot to take.

lexomil overdose

Immediately consult your doctor or pharmacist.

what happen If you stop taking LEXOMIL 6 mg, four-scored tablet?

Withdrawal and rebound phenomena (see Warnings).

If you have any further questions on the use of this medicine, ask your doctor or pharmacist for more information.

What is  Forms and Composition ?

FORMS and PRESENTATIONS

6 mg (white) quadrisecable baguette tablet:   Tube of 30.

Hospital model: Box of 100, in blister packs.

COMPOSITION

  p cp Bromazepam (DCI) 6 mg

Excipients: microcrystalline cellulose, lactose (100 mg / cp), talc, magnesium stearate.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Lexomil tablet Uses, Dosage, Side Effects, Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/35JnQcM via Edrug Online

[greatestlcve]

Lexomil tablet Uses, Dosage, Side Effects, Precautions

Drug Online

lexomil tablet 6mg is Generic drug of the therapeutic class: Neurology – psychiatry active ingredients: Bromazepam

what is lexomil 6mg?

This medicine is recommended in the treatment of anxiety when it is accompanied by troublesome disorders, or in the prevention and / or treatment of manifestations related to alcohol withdrawal.

what is the generic name of lexomil

the generic name of lexomil is Bromazepam

What is the use of Lexotanil and indication ?

Symptomatic treatment of severe and / or disabling anxiety disorders.

Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal.

Lexomil Dosage

The use of bromazepam is not recommended in children, in the absence of study. In addition, the tablet is not a form suitable for children under 6 years (risk of mis-driving).

DOSE :

In all cases, treatment will be initiated at the lowest effective dose and the maximum dose will not be exceeded.

– In current practice :

In adults , the beginning of treatment, the mean daily dose of BROMAZEPAM is 6 mg per day, spread most often as follows:

. 1/4 compressed-wand morning (1.5 mg)

. 1/4 compressed-wand at noon (1.5 mg)

. 1/2 tablet-baguette at night (3 mg).

It must then be adapted individually according to the therapeutic response.

– In psychiatry :

Depending on the severity of the anxiety to be treated: in ambulatory patients, the dosage is between 6 and 18 mg; in subjects whose severity of the anxiety syndrome requires hospitalization, it is possible to prescribe higher doses, 24 or even 36 mg per day.

– In children, the elderly, the renal or hepatic insufficiency : it is recommended to reduce the dosage, by half for example.

DURATION :

Treatment should be as short as possible. The indication will be reviewed regularly especially in the absence of symptoms. The overall duration of treatment should notexceed 8 to 12 weeks for the majority of patients, including the dose reduction period (see section cautionary statements and precautions for use).

In some cases, it may be necessary to prolong the treatment beyond the recommended periods. This requires accurate and repeated assessments of the patient’s condition.

– Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal : short treatment of the order of 8 to 10 days. 

Contraindications

Bromazepam hypersensitivity

Benzodiazepine hypersensitivity

Severe respiratory failure

Severe hepatic impairment

Myasthenia gravis

Sleep apnea syndrome

Child under 6

Galactose intolerance

Glucose malabsorption syndrome

Galactose malabsorption syndrome

Lactase deficiency

Alcohol consumption

Pregnancy

Feeding with milk

This medication should never be used in the following situations:

Known hypersensitivity to benzodiazepines, the active ingredient, or one of the other constituents,

Severe respiratory failure,

Severe acute or chronic liver failure (risk of developing hepatic encephalopathy)

Gravis,

 Sleep apnea syndrome.

How it works ?

DERIVATIVES OF BENZODIAZEPINE.

ATC code: N05BA (anxiolytics).

(N: Central Nervous System).

– The bromazepam belongs to the class of benzodiazepines 1-4 and pharmacodynamic activity qualitatively similar to that of other compounds of this class

. muscle relaxant,

. anxiolytic

. sedative,

. hypnotic

. anticonvulsant,

. amnesic.

These effects are linked to a specific agonist action on a central receptor belonging to the complex “GABA-OMEGA macromolecular receptors”, also called BZ1 and BZ2 and modulating the opening of the chlorine channel.

What is the side effect of Bromazepam (Lexomil)?

Description of adverse effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

They are related to the ingested dose and the individual sensitivity of the patient.

Neuro-psychiatric side effects (see Warnings): Not known

· Memory problems, which can occur at therapeutic doses, the risk increases in proportion to the dose,

· Depression

· Behavior disorders, changes in consciousness, irritability, aggression, agitation,

· Physical and mental dependence, even at therapeutic doses with withdrawal syndrome or rebound at discontinuation of treatment,

· Feelings of vertigo, headaches, difficulty coordinating certain movements,

· Confusion, sleepiness or alertness decline (especially in the elderly), insomnia, nightmares, tension,

· Changes in libido.

Dermal side effects: Not known

· Rash, with or without itching, urticaria.

Cardiac Undesirable Effects: Not known

· Heart failure, including cardiac arrest

Respiratory side effects: Not known

· Decreased respiratory capacity

Gastrointestinal side effects: Not known

· Nausea, vomiting, constipation

Adverse effects of kidney and urinary tract : Not known

· Unable to urinate

Ocular Adverse Reactions: Not known

· Double vision.

Adverse reactions of the immune system: Not known

· Allergies (such as swelling, redness of the skin), including severe allergic reactions (anaphylactic shock, angioedema)

General side effects: Not known

· Muscle weakness, fatigue

Treatment Complications (see Warnings): Not known

· Falls, fractures.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This also applies to any side effects that are not mentioned in this leaflet. You can also report side effects directly via the national reporting system:

National Agency for the Safety of Medicines and Health Products (ANSM) and the network of Regional Pharmacovigilance Centers –

Lexomil (Bromazepam) Side Effects

Lexomil Interactions 

Pharmacodynamic interaction

Associations advised against

Lexomil and Alcohol

Alcohol enhancement of the sedative effect of benzodiazepines and the like. Impairment of alertness can make driving and using machines dangerous. Avoid taking alcoholic drinks and drugs containing alcohol.

Associations to consider

Other central nervous system depressants: Increased central depressant effect with morphine derivatives (analgesics, antitussives and substitution treatments other than buprenorphine); antipsychotics (neuroleptics); barbiturates; other anxiolytics; hypnotics; sedative antidepressants; sedative antihistamines H1; central antihypertensives; anticonvulsants; baclofen; Thalidomide.

Altered alertness can make driving dangerous and the use of machinery dangerous.

In addition, for morphine derivatives (analgesics, antitussives and substitution treatments), barbiturates:

increased risk of respiratory depression, which can be fatal in case of overdose, especially in the elderly.

Buprenorphine

Increased risk of respiratory depression, which can be fatal.

Carefully evaluate the benefit / risk ratio of this combination. Inform the patient of the need to respect the prescribed doses.

Clozapine

Increased risk of collapse with respiratory and / or cardiac arrest.

Pharmacokinetic interaction

Pharmacokinetic interactions may occur when bromazepam is administered with drugs that inhibit the CYP3A4 hepatic enzyme by increasing plasma levels of bromazepam.

Caution should be exercised when concomitant administration of bromazepam with potent CYP3A4 inhibitors (eg, azole antifungals, protease inhibitors, or certain macrolides) and a significant reduction in dosage should be considered. In the case of narcotic analgesics, a potentiation of euphoria may also occur, which may lead to increased psychic dependence.

Lexomil Warnings and Precautions

Warnings

This medicine contains lactose. Its use is contraindicated in patients with galactose intolerance, Lapp lactase deficiency or glucose or galactose malabsorption syndrome (hereditary diseases).

PHARMACOLOGICAL TOLERANCE:

The action of benzodiazepines and relatives may decrease gradually despite the use of the same dose in case of repeated administration for several weeks.

ADDICTION:

Any treatment with benzodiazepines and related drugs, especially with prolonged use, may result in a state of physical and mental dependence.

Various factors seem to favor the occurrence of dependence:

· Duration of treatment,

· Dose,

· History of other addictions: medication or not, including alcoholic.

Drug dependence may occur at therapeutic doses and / or in patients without individualized risk factors.

This state can lead to the cessation of treatment a withdrawal phenomenon.

Some symptoms are common and seemingly trivial: insomnia, headache, diarrhea, extreme anxiety, myalgia, tension, irritability, nervousness, confusion.

In severe cases the following symptoms may occur: hyperacusis, agitation or even confusional episode, paresthesia of the extremities, hypersensitivity to light, noise, and physical contact, depersonalization, derealization, hallucinatory phenomena, convulsions.

Withdrawal symptoms may occur within days of stopping treatment. For short-acting benzodiazepines, and especially if given at high doses, symptoms may even occur in the interval between two doses.

When using long-acting benzodiazepines, it is important to inform the patient that switching to a short-acting benzodiazepine may result in withdrawal symptoms.

The combination of several benzodiazepines may, regardless of the anxiolytic or hypnotic indication, increase the risk of drug dependence.

Cases of abuse have been reported.

REBOUND PHENOMENON / WEANING

This transient syndrome may manifest itself at the end of the treatment by the reappearance, in an accentuated form, of the symptoms of anxiety and insomnia which motivated the treatment with the benzodiazepines and allied ones.

 It may be accompanied by other reactions including mood changes, anxiety or sleep disturbances, and nervousness.

As the risk of rebound / weaning is higher after abrupt cessation of treatment, it is recommended to gradually reduce the dosage.

AMNESIA AND ALTERATIONS OF PSYCHOMOTIC FUNCTIONS

Anterograde amnesia and alterations in psychomotor function may occur within hours of taking the drug. Therefore, to reduce the risk, patients must be sure to sleep uninterrupted sleep for several hours after taking it. The effects of amnesia may be associated with inappropriate behavior.

PSYCHIATRIC AND PARADOXAL REACTIONS

In some subjects, benzodiazepines and related products may result in a syndrome associating to varying degrees an impairment of consciousness and behavioral and memory disorders may be observed:

· Worsening of insomnia, nightmares, agitation, nervousness,

· Delusions, hallucinations, confuso-oniric state, psychotic type symptoms,

· Disinhibition with impulsiveness,

· Euphoria, irritability,

· Anterograde amnesia,

· Suggestibility.

This syndrome may be accompanied by potentially dangerous disorders for the patient or for others, such as:

· Inappropriate behavior for the patient,

· Anger attacks, self- or hetero-aggressive behavior, especially if the entourage tries to hinder the patient’s activity,

· Automatic driving with post-event amnesia.

These events require the cessation of treatment. These reactions are more likely to occur in children and the elderly.

RISK OF ACCUMULATION

Benzodiazepines and related drugs (like all drugs) persist in the body for a period of about 5 half-lives.

In the elderly or with renal or hepatic insufficiency, the half-life may be considerably longer. When taken repeatedly, the drug or its metabolites reach the equilibrium plateau much later and at a much higher level. It is only after obtaining a balance plateau that it is possible to evaluate both the efficacy and the safety of the drug.

Dosage adjustment may be necessary (see section 4.2). The patient should be monitored regularly at the beginning of treatment in order to decrease the dosage and / or the frequency of administration and to prevent the occurrence of accumulation-related overdose.

SUBJECT AGE

Benzodiazepines and related products should be used with caution in the elderly, because of the risk of sedation and / or myorelaxant effect that may lead to falls, with often severe consequences in this population.

CONCOMITANT USE OF ALCOHOL / CNS DEPRESSANTS

Concomitant use of bromazepam with alcohol and / or CNS depressants should be avoided. This concomitant use may increase the clinical effects of bromazepam, including severe sedation and clinically relevant respiratory and / or cardiovascular depression.

Precautions for use

Great caution is recommended in case of a history of alcoholism or other addictions, whether medicated or not .

AT THE SUBJECT WITH A MAJOR DEPRESSIVE EPISODE

Benzodiazepines and related drugs should not be used alone to treat depression or anxiety associated with depression.

The latter may evolve on its own account with persistence or increase in suicidal risk.

 Bromazepam should therefore be used with caution and the duration of treatment should be limited in patients with signs and symptoms of depressive disorder or suicidal tendencies.

Benzodiazepines are not recommended for the first-line treatment of psychotic illnesses.

DURATION OF TREATMENT

The duration of treatment should be as short as possible and should not exceed 8 to 12 weeks, including the dose reduction phase.

 If it is necessary to prolong the treatment beyond this time, the patient’s condition must be re-evaluated. It is useful to inform the patient when initiating treatment that it will be of limited duration.

PROGRESSIVE STOPPING PROCEDURES FOR TREATMENT

They must be stated to the patient precisely.

In addition to the need for gradual decrease in doses, patients should be warned of the possibility of a rebound phenomenon, to minimize the anxiety that may arise from the symptoms related to this interruption, even progressive.

The patient should be warned of the possibly uncomfortable nature of this phase.

CHILD:

Even more than in adults, the benefit / risk ratio will be carefully evaluated and the duration of treatment as short as possible. No clinical studies have been conducted in children with bromazepam.

SUBJECT AGE, INSUFFICIENT RENAL AND INSUFFICIENT HEPATIC:

The risk of accumulation leads to a reduction in dosage, for example by half .

Benzodiazepines are contraindicated in patients with severe hepatic impairment (risk of encephalopathy).

INSUFFICIENT RESPIRATORY

In patients with respiratory insufficiency, the depressant effect of benzodiazepines and related substances should be taken into account (especially since anxiety and agitation may be signs of a call for a decompensation of the respiratory function which justifies the transition to intensive care unit). It is recommended to reduce the dose.

Drive and use machines

Prevent drivers of vehicles and machinery users from the risk of drowsiness, sedation, amnesia, impaired concentration and impaired muscle function.

The combination with other sedative drugs should be discouraged or taken into account when driving or using machines ( see Interactions ).

If sleep time is insufficient, the risk of impaired alertness is further increased. This effect is increased if the patient has consumed alcohol.

overdose from Lexomil (Bromazepam)

PREGNANCY / BREAST FEEDING / FERTILITY

lexomil and pregnancy

Many data from cohort studies have not revealed the occurrence of malformative effects during benzodiazepine exposure during the course of 1first  trimester of pregnancy. 

However, in some case-control epidemiological studies, an increase in the occurrence of cleft lip and palate has been observed with benzodiazepines. 

According to these data, the incidence of cleft lip and palate in newborns would be less than 2/1000 after exposure to benzodiazepines during pregnancy while the expected rate in the general population is 1/1000.

If benzodiazepines are taken in high doses at 2 nd and / or 3 rdtrimesters of pregnancy, a decrease in fetal active movements and a variability in fetal heart rate have been described. Treatment with benzodiazepines at the end of pregnancy, even at low doses, may be responsible in the newborn for signs of impregnation such as axial hypotonia, sucking disorders resulting in low weight gain. These signs are reversible, but may last 1-3 weeks depending on the half-life of the prescribed benzodiazepine. At high doses, respiratory depression or apnea, and hypothermia may occur in the newborn. In addition, a syndrome of neonatal withdrawal is possible, even in the absence of signs of impregnation. It is characterized in particular by hyperexcitability, agitation and tremulations of the newborn occurring at a distance from the delivery. The time of onset depends on the elimination half-life of the drug and may be important when it is long.

Given these data, as a precautionary measure, the use of bromazepam is not recommended during pregnancy for any term.

When prescribing bromazepam to a woman of childbearing age, she should be advised of the need to contact her doctor if a pregnancy is planned or started to re-assess the benefit of the treatment.

At the end of pregnancy, if it is really necessary to start treatment with bromazepam, avoid prescribing high doses and take into account, for the surveillance of the newborn, the effects described above.

Breastfeeding

Bromazepam passes into breast milk; therefore, the use of this medicine during breastfeeding is not recommended.

What should I do if I miss a dose?

Take the next dose at the usual time. Do not take a double dose to make up for the dose you forgot to take.

lexomil overdose

Immediately consult your doctor or pharmacist.

What is  Forms and Composition ?

FORMS and PRESENTATIONS

6 mg (white) quadrisecable baguette tablet:   Tube of 30.

Hospital model: Box of 100, in blister packs.

COMPOSITION

 p cpBromazepam (DCI)6 mg

Excipients: microcrystalline cellulose, lactose (100 mg / cp), talc, magnesium stearate.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Lexomil tablet Uses, Dosage, Side Effects, Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/3c6a59f via Edrug Online from Faculty of Medicine https://bit.ly/3mtxO8k via Internal Medicine

[greatestlcve]

Lexomil tablet Uses, Dosage, Side Effects, Precautions

Drug Online

lexomil tablet 6mg is Generic drug of the therapeutic class: Neurology – psychiatry active ingredients: Bromazepam

what is lexomil 6mg tablet

This medicine is recommended in the treatment of anxiety when it is accompanied by troublesome disorders, or in the prevention and / or treatment of manifestations related to alcohol withdrawal.

Lexomil (Bromazepam) (Bromazepam) Uses, Dosage, Side Effects, Precautions

what is the generic name of lexomil

the generic name of lexomil is Bromazepam

What is the use of Lexotanil and indication ?

Symptomatic treatment of severe and / or disabling anxiety disorders.

Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal.

Lexomil Dosage

The use of bromazepam is not recommended in children, in the absence of study. In addition, the tablet is not a form suitable for children under 6 years (risk of mis-driving).

DOSE :

In all cases, treatment will be initiated at the lowest effective dose and the maximum dose will not be exceeded.

– In current practice :

In adults , the beginning of treatment, the mean daily dose of BROMAZEPAM is 6 mg per day, spread most often as follows:

. 1/4 compressed-wand morning (1.5 mg)

. 1/4 compressed-wand at noon (1.5 mg)

. 1/2 tablet-baguette at night (3 mg).

It must then be adapted individually according to the therapeutic response.

– In psychiatry :

Depending on the severity of the anxiety to be treated: in ambulatory patients, the dosage is between 6 and 18 mg; in subjects whose severity of the anxiety syndrome requires hospitalization, it is possible to prescribe higher doses, 24 or even 36 mg per day.

– In children, the elderly, the renal or hepatic insufficiency : it is recommended to reduce the dosage, by half for example.

DURATION :

Treatment should be as short as possible. The indication will be reviewed regularly especially in the absence of symptoms. The overall duration of treatment should notexceed 8 to 12 weeks for the majority of patients, including the dose reduction period (see section cautionary statements and precautions for use).

In some cases, it may be necessary to prolong the treatment beyond the recommended periods. This requires accurate and repeated assessments of the patient’s condition.

– Prevention and treatment of delirium tremens and other manifestations of alcohol withdrawal : short treatment of the order of 8 to 10 days. 

Contraindications

Bromazepam hypersensitivity

Benzodiazepine hypersensitivity

Severe respiratory failure

Severe hepatic impairment

Myasthenia gravis

Sleep apnea syndrome

Child under 6

Galactose intolerance

Glucose malabsorption syndrome

Galactose malabsorption syndrome

Lactase deficiency

Alcohol consumption

Pregnancy

Feeding with milk 

This medication should never be used in the following situations:

Known hypersensitivity to benzodiazepines, the active ingredient, or one of the other constituents,

Severe respiratory failure,

Severe acute or chronic liver failure (risk of developing hepatic encephalopathy)

Gravis,

 Sleep apnea syndrome.

How it works ?

DERIVATIVES OF BENZODIAZEPINE.

ATC code: N05BA (anxiolytics).

(N: Central Nervous System).

– The bromazepam belongs to the class of benzodiazepines 1-4 and pharmacodynamic activity qualitatively similar to that of other compounds of this class

. muscle relaxant,

. anxiolytic

. sedative,

. hypnotic

. anticonvulsant,

. amnesic.

These effects are linked to a specific agonist action on a central receptor belonging to the complex “GABA-OMEGA macromolecular receptors”, also called BZ1 and BZ2 and modulating the opening of the chlorine channel.

What is the side effect of Bromazepam (Lexomil)?

Description of adverse effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

They are related to the ingested dose and the individual sensitivity of the patient.

Neuro-psychiatric side effects (see Warnings): Not known

· Memory problems, which can occur at therapeutic doses, the risk increases in proportion to the dose,

· Depression

· Behavior disorders, changes in consciousness, irritability, aggression, agitation,

· Physical and mental dependence, even at therapeutic doses with withdrawal syndrome or rebound at discontinuation of treatment,

· Feelings of vertigo, headaches, difficulty coordinating certain movements,

· Confusion, sleepiness or alertness decline (especially in the elderly), insomnia, nightmares, tension,

· Changes in libido.

Dermal side effects: Not known

· Rash, with or without itching, urticaria.

Cardiac Undesirable Effects: Not known

· Heart failure, including cardiac arrest

Respiratory side effects: Not known

· Decreased respiratory capacity

Gastrointestinal side effects: Not known

· Nausea, vomiting, constipation

Adverse effects of kidney and urinary tract : Not known

· Unable to urinate

Ocular Adverse Reactions: Not known

· Double vision.

Adverse reactions of the immune system: Not known

· Allergies (such as swelling, redness of the skin), including severe allergic reactions (anaphylactic shock, angioedema)

General side effects: Not known

· Muscle weakness, fatigue

Treatment Complications (see Warnings): Not known

· Falls, fractures.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This also applies to any side effects that are not mentioned in this leaflet. You can also report side effects directly via the national reporting system:

National Agency for the Safety of Medicines and Health Products (ANSM) and the network of Regional Pharmacovigilance Centers –

Lexomil (Bromazepam) Side Effects

Lexomil Interactions 

Pharmacodynamic interaction

Associations advised against

Lexomil and Alcohol

Alcohol enhancement of the sedative effect of benzodiazepines and the like. Impairment of alertness can make driving and using machines dangerous. Avoid taking alcoholic drinks and drugs containing alcohol.

Associations to consider

Other central nervous system depressants: Increased central depressant effect with morphine derivatives (analgesics, antitussives and substitution treatments other than buprenorphine); antipsychotics (neuroleptics); barbiturates; other anxiolytics; hypnotics; sedative antidepressants; sedative antihistamines H1; central antihypertensives; anticonvulsants; baclofen; Thalidomide.

Altered alertness can make driving dangerous and the use of machinery dangerous.

In addition, for morphine derivatives (analgesics, antitussives and substitution treatments), barbiturates:

increased risk of respiratory depression, which can be fatal in case of overdose, especially in the elderly.

Buprenorphine

Increased risk of respiratory depression, which can be fatal.

Carefully evaluate the benefit / risk ratio of this combination. Inform the patient of the need to respect the prescribed doses.

Clozapine

Increased risk of collapse with respiratory and / or cardiac arrest.

Pharmacokinetic interaction

Pharmacokinetic interactions may occur when bromazepam is administered with drugs that inhibit the CYP3A4 hepatic enzyme by increasing plasma levels of bromazepam.

Caution should be exercised when concomitant administration of bromazepam with potent CYP3A4 inhibitors (eg, azole antifungals, protease inhibitors, or certain macrolides) and a significant reduction in dosage should be considered. In the case of narcotic analgesics, a potentiation of euphoria may also occur, which may lead to increased psychic dependence.

Lexomil Warnings and Precautions

Warnings

This medicine contains lactose. Its use is contraindicated in patients with galactose intolerance, Lapp lactase deficiency or glucose or galactose malabsorption syndrome (hereditary diseases).

PHARMACOLOGICAL TOLERANCE:

The action of benzodiazepines and relatives may decrease gradually despite the use of the same dose in case of repeated administration for several weeks.

ADDICTION:

Any treatment with benzodiazepines and related drugs, especially with prolonged use, may result in a state of physical and mental dependence.

Various factors seem to favor the occurrence of dependence:

· Duration of treatment,

· Dose,

· History of other addictions: medication or not, including alcoholic.

Drug dependence may occur at therapeutic doses and / or in patients without individualized risk factors.

This state can lead to the cessation of treatment a withdrawal phenomenon.

Some symptoms are common and seemingly trivial: insomnia, headache, diarrhea, extreme anxiety, myalgia, tension, irritability, nervousness, confusion.

In severe cases the following symptoms may occur: hyperacusis, agitation or even confusional episode, paresthesia of the extremities, hypersensitivity to light, noise, and physical contact, depersonalization, derealization, hallucinatory phenomena, convulsions.

Withdrawal symptoms may occur within days of stopping treatment. For short-acting benzodiazepines, and especially if given at high doses, symptoms may even occur in the interval between two doses.

When using long-acting benzodiazepines, it is important to inform the patient that switching to a short-acting benzodiazepine may result in withdrawal symptoms.

The combination of several benzodiazepines may, regardless of the anxiolytic or hypnotic indication, increase the risk of drug dependence.

Cases of abuse have been reported.

REBOUND PHENOMENON / WEANING

This transient syndrome may manifest itself at the end of the treatment by the reappearance, in an accentuated form, of the symptoms of anxiety and insomnia which motivated the treatment with the benzodiazepines and allied ones.

 It may be accompanied by other reactions including mood changes, anxiety or sleep disturbances, and nervousness.

As the risk of rebound / weaning is higher after abrupt cessation of treatment, it is recommended to gradually reduce the dosage.

AMNESIA AND ALTERATIONS OF PSYCHOMOTIC FUNCTIONS

Anterograde amnesia and alterations in psychomotor function may occur within hours of taking the drug. Therefore, to reduce the risk, patients must be sure to sleep uninterrupted sleep for several hours after taking it. The effects of amnesia may be associated with inappropriate behavior.

PSYCHIATRIC AND PARADOXAL REACTIONS

In some subjects, benzodiazepines and related products may result in a syndrome associating to varying degrees an impairment of consciousness and behavioral and memory disorders may be observed:

· Worsening of insomnia, nightmares, agitation, nervousness,

· Delusions, hallucinations, confuso-oniric state, psychotic type symptoms,

· Disinhibition with impulsiveness,

· Euphoria, irritability,

· Anterograde amnesia,

· Suggestibility.

This syndrome may be accompanied by potentially dangerous disorders for the patient or for others, such as:

· Inappropriate behavior for the patient,

· Anger attacks, self- or hetero-aggressive behavior, especially if the entourage tries to hinder the patient’s activity,

· Automatic driving with post-event amnesia.

These events require the cessation of treatment. These reactions are more likely to occur in children and the elderly.

RISK OF ACCUMULATION

Benzodiazepines and related drugs (like all drugs) persist in the body for a period of about 5 half-lives.

In the elderly or with renal or hepatic insufficiency, the half-life may be considerably longer. When taken repeatedly, the drug or its metabolites reach the equilibrium plateau much later and at a much higher level. It is only after obtaining a balance plateau that it is possible to evaluate both the efficacy and the safety of the drug.

Dosage adjustment may be necessary (see section 4.2). The patient should be monitored regularly at the beginning of treatment in order to decrease the dosage and / or the frequency of administration and to prevent the occurrence of accumulation-related overdose.

SUBJECT AGE

Benzodiazepines and related products should be used with caution in the elderly, because of the risk of sedation and / or myorelaxant effect that may lead to falls, with often severe consequences in this population.

CONCOMITANT USE OF ALCOHOL / CNS DEPRESSANTS

Concomitant use of bromazepam with alcohol and / or CNS depressants should be avoided. This concomitant use may increase the clinical effects of bromazepam, including severe sedation and clinically relevant respiratory and / or cardiovascular depression.

Precautions for use

Great caution is recommended in case of a history of alcoholism or other addictions, whether medicated or not .

AT THE SUBJECT WITH A MAJOR DEPRESSIVE EPISODE

Benzodiazepines and related drugs should not be used alone to treat depression or anxiety associated with depression.

The latter may evolve on its own account with persistence or increase in suicidal risk.

 Bromazepam should therefore be used with caution and the duration of treatment should be limited in patients with signs and symptoms of depressive disorder or suicidal tendencies.

Benzodiazepines are not recommended for the first-line treatment of psychotic illnesses.

DURATION OF TREATMENT

The duration of treatment should be as short as possible and should not exceed 8 to 12 weeks, including the dose reduction phase.

 If it is necessary to prolong the treatment beyond this time, the patient’s condition must be re-evaluated. It is useful to inform the patient when initiating treatment that it will be of limited duration.

PROGRESSIVE STOPPING PROCEDURES FOR TREATMENT

They must be stated to the patient precisely.

In addition to the need for gradual decrease in doses, patients should be warned of the possibility of a rebound phenomenon, to minimize the anxiety that may arise from the symptoms related to this interruption, even progressive.

The patient should be warned of the possibly uncomfortable nature of this phase.

CHILD:

Even more than in adults, the benefit / risk ratio will be carefully evaluated and the duration of treatment as short as possible. No clinical studies have been conducted in children with bromazepam.

SUBJECT AGE, INSUFFICIENT RENAL AND INSUFFICIENT HEPATIC:

The risk of accumulation leads to a reduction in dosage, for example by half .

Benzodiazepines are contraindicated in patients with severe hepatic impairment (risk of encephalopathy).

INSUFFICIENT RESPIRATORY

In patients with respiratory insufficiency, the depressant effect of benzodiazepines and related substances should be taken into account (especially since anxiety and agitation may be signs of a call for a decompensation of the respiratory function which justifies the transition to intensive care unit). It is recommended to reduce the dose.

Drive and use machines

Prevent drivers of vehicles and machinery users from the risk of drowsiness, sedation, amnesia, impaired concentration and impaired muscle function.

The combination with other sedative drugs should be discouraged or taken into account when driving or using machines ( see Interactions ).

If sleep time is insufficient, the risk of impaired alertness is further increased. This effect is increased if the patient has consumed alcohol.

overdose from Lexomil (Bromazepam)

PREGNANCY / BREAST FEEDING / FERTILITY

lexomil and pregnancy

Many data from cohort studies have not revealed the occurrence of malformative effects during benzodiazepine exposure during the course of 1first  trimester of pregnancy. 

However, in some case-control epidemiological studies, an increase in the occurrence of cleft lip and palate has been observed with benzodiazepines. 

According to these data, the incidence of cleft lip and palate in newborns would be less than 2/1000 after exposure to benzodiazepines during pregnancy while the expected rate in the general population is 1/1000.

If benzodiazepines are taken in high doses at 2 nd and / or 3 rdtrimesters of pregnancy, a decrease in fetal active movements and a variability in fetal heart rate have been described. Treatment with benzodiazepines at the end of pregnancy, even at low doses, may be responsible in the newborn for signs of impregnation such as axial hypotonia, sucking disorders resulting in low weight gain. These signs are reversible, but may last 1-3 weeks depending on the half-life of the prescribed benzodiazepine. At high doses, respiratory depression or apnea, and hypothermia may occur in the newborn. In addition, a syndrome of neonatal withdrawal is possible, even in the absence of signs of impregnation. It is characterized in particular by hyperexcitability, agitation and tremulations of the newborn occurring at a distance from the delivery. The time of onset depends on the elimination half-life of the drug and may be important when it is long.

Given these data, as a precautionary measure, the use of bromazepam is not recommended during pregnancy for any term.

When prescribing bromazepam to a woman of childbearing age, she should be advised of the need to contact her doctor if a pregnancy is planned or started to re-assess the benefit of the treatment.

At the end of pregnancy, if it is really necessary to start treatment with bromazepam, avoid prescribing high doses and take into account, for the surveillance of the newborn, the effects described above.

Breastfeeding

Bromazepam passes into breast milk; therefore, the use of this medicine during breastfeeding is not recommended.

What should I do if I miss a dose?

Take the next dose at the usual time. Do not take a double dose to make up for the dose you forgot to take.

lexomil overdose

Immediately consult your doctor or pharmacist.

What is  Forms and Composition ?

FORMS and PRESENTATIONS

6 mg (white) quadrisecable baguette tablet:   Tube of 30.

Hospital model: Box of 100, in blister packs.

COMPOSITION

 p cpBromazepam (DCI)6 mg

Excipients: microcrystalline cellulose, lactose (100 mg / cp), talc, magnesium stearate.

NOT’s

Edrug-online contains comprehensive and detailed information about drugs available in the medical field, and is divided into four sections:

general information:

Includes a general description of the drug, its use, brand names, FAQs, and relevant news and articles

Additional information:

General explanation about dealing with the medicine: how to take the medicine, the doses and times of it, the start and duration of its effectiveness, the recommended diet during the period of taking the medicine, the method of storage and storage, recommendations in cases for forgetting the dose and instructions to stop taking the drug and take additional doses.

Special warnings:

For pregnant and breastfeeding women, the elderly, boys and drivers, and use before surgery.

Side effects:

It treats possible side effects and drug interactions that require attention and its effect on continuous use.

The information contained in this medicine is based on medical literature, but it is not a substitute for consulting a doctor.

The post Lexomil tablet Uses, Dosage, Side Effects, Precautions appeared first on Drug Online.

from Drug Online https://bit.ly/2QeAI1x via Edrug Online from Faculty of Medicine https://bit.ly/3j9BTvT via Internal Medicine