#probenecid to enhance elimination
Explore tagged Tumblr posts
Text
What Is Uric Acid and How It Affects Our Health
Although it is still debatable we have some clues to deal with this sneaky acid mainly hidden in junk foods Hyperuricemia In this short post, I will introduce you to uric acid because this sneaky acid something as small as a molecule could make or break our health. Uric acid is a tiny waste product that forms when our bodies break down purines , natural compounds in food some food.  Sounds…
0 notes
laurasmithme-blog · 5 years ago
Text
Zovirax 200mg
DESCRIPTION
Zovirax 200mg belongs to the group of medicines known as antivirals, which are required to treat infections caused by viruses.
Typically,these medicines work for only one type of virus infections. Zovirax 200mg is also knowns as Acycloguanosine, Zovirax 200mg is a prescription drugs administrated orally which is used under the supervision of medical practioners. Zovirax 200mg tablet is used with combination of other medications.
Tumblr media
Zovirax 200mg is a type of nucleoside analogs (group of synthetic drugs), will inhibit the symptoms of infection contains Herpes Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV(varicella-Zoster virus) and thereby causes shingles and chickenpox.
INDICATION
Zovirax 200mg is indicated to lowers the pain and rapid healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster.
Tumblr media
Zovirax 200mg is also indicated for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from time to time(genital herpes) and hence blocks the outbreaks of genital herpes in people affected by virus.
MECHANISM OF ACTION
Zovirax isexcited by phosphorylation before to that drug will preventssynthesis ofviral DNA. Zovirax changes by addition of phosphate group to
a viral enzyme known as thymidine kinase has more affinity. HSV-TK or VZV-TK by phosphorylation converts into acyclovir triphosphate then combined into viral DNA, thereby stops further DNA synthesis.Since Zovirax attack to a selective type of viral kinase, the drugs enter and works on those cells infected with HSV or VZV, hence it will demobilize the formation of herpesvirus DNA. At high concentration has low activity in uninfected cells, Here by HSV-TK or VZV-TK mutation will lead resistance to acyclovir.
Tumblr media
ADME PROPERTIES
ABSORPTION
bad water soluble, high plasma concentration after 1-2 hours and bioavailability 15-30%.
DISTRIBUTION
human serum protein binding is about 9 to 33%.
METABOLISM & ELIMINATION
half-life based concede to age group neonates have t1/2 is 4 hours, children’s have 2-3 hours and for adults t1/2 is 3 hours.
OVERDOSAGE
Zovirax 200mg contains ingestion of 100 capsules ( 20g) have been resulted has agitation, coma, seizures and lethargy. If overdose occurs provide supportive measures.
DRUG INTERACTION
Zovirax concomitant use with probenecid will reduce tubular secretion of acyclovir and increase the blood plasma and half- life of acyclovir. Interaction of Zovirax with nephrotoxic drugs may cause increase the risk in renal function Interaction with immunostimulators will enhancing effects of acyclovir
CONTRAINDICATION
Zovirax is contraindicated in patients who causes hypersensitivity to acyclovir or valacyclovir.
Tumblr media
.
PRECAUTION
Zovirax 200mg cause allergic reaction like breathing trouble, swelling of throat or tongue, rash, hives. Inform your doctor if symptoms occur. Discuss with your consultant about planning to become pregnant or pregnancy because drug can be used if possible benefits clarify possible risk to the patients. Discuss with doctor If you had kidney disease because the excretion of drug will not perform well, Zovirax 200mg will decrease the kidney function.
PREGNANCY
Category B: In animal studies it has not shown harm to the fetus and In human no enough studies carried out in pregnant women to describe the harm to the fetus. Drug used only if possible benefits clarify possible risk to the patients.
MISSED DOSE
If dose missed by patients then take the dose immediately. If next dose time reaches leave the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for further details.
CONTACT US
PHONE NO:+919940472902
WEBSITE:https://pillsbag.com/products/zovirax-200mg
0 notes
questionharsha-blog · 5 years ago
Text
Naproxen- What Are The Indications and Drug Interactions?
Naproxen is a Non-Steroid Anti-Inflammatory Drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body.
Clinical Indications:
1) Rheumatoid arthritis.
2) Osteoarthritis (degenerative arthritis).
3) Ankylosing spondylitis.
4) Juvenile rheumatoid arthritis.
5) Acute gout.
6) Acute musculoskeletal disorders.
7) Dysmenorrhoea.
Posology:
Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 500mg-1g daily in 2 doses at 12 intervals, or if 1g daily is required, it is administered as two 500mg doses or as a single dose.
Acute gout: Initially, 750mg followed by 250mg every 8 hours.
Acute musculoskeletal disorders and dysmenorrhoea: Initially, 500mg followed by 250mg every 6-8 hours as necessary to a maximum of 1250mg daily after the first day.
Children over 5 years: For juvenile rheumatoid arthritis, 10mg/kg a day taken in two doses every 12 hours.
Contraindications:
Naproxen is contraindicated in patients with-
Active GI bleeding or peptic ulceration, known hypersensitivity to naproxen, naproxen sodium, or any other ingredient in the formulation.
Active or history of recurrent peptic ulcer/hemorrhage
Previously shown hypersensitivity reactions such as asthma, rhinitis, angioedema or urticaria in response to ibuprofen or other NSAIDs.
Severe heart failure, hepatic failure, and renal failure
During the last trimester of pregnancy
History of GI bleeding or perforation, related to previous NSAIDs therapy.
Drug Interactions:
Anticoagulants- Closely MONITOR
Naproxen is highly protein-bound, and hence, patients receiving hydantoins, anticoagulants, or a highly protein-bound sulfonamide should be closely monitored for signs of a drug overdose.
Sulfonylureas- Caution
Though no interactions have been observed with naproxen and sulfonylureas, caution is advised since interaction has been seen with other NSAIDs.
Lithium Levels- Closely MONITOR
NSAIDs, including naproxen, have been reported to increase steady-state plasma lithium levels by inhibition of renal lithium clearance. Hence these levels should be monitored whenever initiating, adjusting, or discontinuing naproxen.
Anti-hypertensives: Use with CAUTION
Reduced anti-hypertensive effect. Concomitant administration of naproxen with beta-blockers such as propranolol may reduce the antihypertensive effect and may increase renal impairment risk associated with the use of ACE inhibitors or angiotensin II receptor blockers.
Probenecid - Closely MONITOR
When given concurrently, it increases naproxen plasma levels and extends its half-life considerably.
Methotrexate- Use with CAUTION
Decreased elimination of methotrexate; caution is advised when methotrexate is administered concurrently, due to the possible enhancement of its toxicity as naproxen, like other NSAIDs, has been reported to reduce the tubular secretion of methotrexate.
Furosemide- Use with CAUTION
Withdrawn naproxen use 48 hours before performing adrenal function tests as it may interfere with some tests for 17-ketogenic steroids and with some assays of urinary 5-hydroxyindoleacetic acid.
Cardiac glycosides- Closely MONITOR
NSAIDs may precipitate cardiac failure, reduce GFR, and increase plasma cardiac glycoside levels when co-administered with cardiac glycosides.
Ciclosporin- Use with CAUTION
Caution is advised when ciclosporin is co-administered with any NSAID as it increases the risk of nephrotoxicity.
Mifepristone- Use with CAUTION
Avoid using NSAIDs for 8-12 days after mifepristone administration as NSAIDs can reduce the effects of mifepristone.
Corticosteroids- Use with CAUTION
As with all NSAIDs, caution should be taken when co-administering with corticosteroids as it increases the risk of gastrointestinal ulceration or bleeding.
COX-2 Inhibitors- Do NOT Use
Avoid co-administration of two or more NSAIDs like other analgesics, including cyclooxygenase-2 selective inhibitors, as this may increase the risk of adverse effects.
Diuretics: Use with CAUTION
NSAIDs reduce the effect of diuretics and antihypertensive medications and there is a risk of acute renal insufficiency. Hence, the combination should be administered with caution, especially in the elderly.
Quinolone antibiotics: Use with CAUTION
NSAIDs may increase the risk of convulsions associated with quinolone antibiotics. Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions.
Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs): Use with CAUTION
There is an increased risk of GI bleeding.
Tacrolimus: Use with CAUTION
Tacrolimus plus NSAID may increase the risk of nephrotoxicity.
Zidovudine: Use with CAUTION
NSAIDs, when given with zidovudine, increases the risk of hematological toxicity.
Bisphosphonates: Use with CAUTION
Co-administration of bisphosphonates and NSAIDs may increase the risk of gastric mucosal damage.
Colestyramine: Use with CAUTION
Colestyramine delays the absorption of naproxen and hence should be taken at least one hour before or four to six hours after colestyramine.
ASA: Use with CAUTION
Naproxen usage for more than one day consecutively may inhibit the effect of low-dose aspirin on platelet activity, and this inhibition may persist for up to several days after stopping naproxen use.
Read more https://wcts.app/Naproxen
0 notes
your-own-medical-agency · 5 years ago
Link
Makes use of:
Amoxicillin Suspension-Oral,Amoxil
 Amoxicillin is used to treat a huge sort of bacterial infections. This treatment is a penicillin-type antibiotic. it really works via way of preventing the boom of micro organism.This antibiotic treats simplest bacterial infections. it will now not artwork for viral infections (inclusive of common cold, flu). unnecessary use or misuse of any antibiotic can cause its decreased effectiveness.Amoxicillin is likewise used with other medicinal drugs to deal with belly/intestinal ulcers as a consequence of the micro organism H. pylori and to save you the ulcers from returning.
The Manner to use:
 Shake the bottle well earlier than every dose. cautiously degree the dose the usage of a unique measuring tool/spoon. Do no longer use a circle of relatives spoon due to the reality you could no longer get the proper dose. Take this medication through mouth without or with food as directed with the useful resource of your health practitioner, commonly each 8 or 12 hours. The dosage is based totally completely in your scientific state of affairs and reaction to remedy.you can add the measured dose to formulation, milk, juice, water, or ginger ale just in advance than use. Drink all of the aggregate to get the whole dose. Do now not combo in advance of time for destiny use.Drink masses of fluids at the identical time as the usage of this remedy until your medical doctor tells you in any other case.Antibiotics paintings exceptional at the same time as the quantity of drugs in your body is saved at a normal diploma. consequently, take this drug at frivolously spaced durations. to help you preserve in mind, take it at the equal times each day.hold to take this remedy until the entire prescribed amount is finished, regardless of the truth that symptoms disappear after a few days. stopping the medication too early may allow bacteria to maintain growing, which can also additionally bring about a return of the infection.inform your doctor in case your circumstance persists or worsens.
  Amoxicillin Suspension-Side results   
 Nausea, vomiting, or diarrhea may additionally occur. If any of those effects persist or worsen, tell your clinical physician or pharmacist proper away.This medication can also cause transient staining of the teeth. right brushing will commonly dispose of any stains and prevent them from taking place.remember the fact that your medical doctor has prescribed this medication due to the fact she or he has judged that the gain to you is greater than the risk of side results. Many human beings using this remedy do not have extreme aspect outcomes.Use of this medication for prolonged or repeated intervals also can bring about oral thrush or a new vaginal yeast contamination (oral or vaginal fungal contamination). contact your medical doctor if you note white patches on your mouth, a exchange in vaginal discharge or specific new signs and symptoms and signs.tell your medical doctor at once if any of these uncommon but severe issue consequences arise: dark urine, continual nausea or vomiting, belly/stomach ache, yellowing eyes or skin, easy bruising or bleeding, persistent sore throat or fever.This remedy might also moreover rarely cause a extreme intestinal scenario (Clostridium difficile-related diarrhea) because of a type of resistant bacteria. This situation may additionally rise up at some point of treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain drug treatments if you have the following symptoms due to the reality the ones products might also motive them to worse. inform your health practitioner right now in case you amplify: chronic diarrhea, stomach or stomach pain/cramping, blood/mucus for your stool.a completely vital allergic reaction to this drug is uncommon. however, get medical assist right away if you phrase any symptoms of a severe allergy, along side: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, hassle respiratory.Amoxicillin can normally motive a moderate rash this is commonly now not serious. however, you can not have the ability to tell it aside from an fantastic rash that may be a sign of a immoderate hypersensitive reaction. therefore, get scientific assist proper away if you expand any rash.This isn't always a entire listing of viable issue results. in case you phrase different effects not indexed above, touch your doctor or pharmacist
Amoxicillin Suspension-Precaution
 Earlier than taking amoxicillin, tell your health practitioner or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have another hypersensitive reactions. This product may additionally incorporate inactive ingredients, which could reason allergies or different troubles. communicate for your pharmacist for more information.earlier than using this medicinal drug, inform your doctor or pharmacist your scientific records, mainly of: kidney sickness, a positive type of viral infection (infectious mononucleosis).Amoxicillin suspension may include sugar. caution is advised when you have diabetes or some other condition that calls for you to limit/keep away from sugar to your weight-reduction plan. Ask your medical doctor or pharmacist approximately the use of this product adequately.earlier than having surgical procedure, inform your doctor or dentist approximately all the goods you operate (which includes pharmaceuticals, nonprescription pills, and natural products).at some stage in pregnancy, this remedy need to be used most effective while certainly wished. talk the risks and advantages together with your health practitioner.Amoxicillin passes into breast milk. seek advice from your doctor earlier than breast-feeding.
 Amoxicillin Suspension-  Drug Interactions
The consequences of some tablets can exchange in case you take different pills or herbal products at the equal time. this can boom your chance for critical facet outcomes or may additionally cause your medicinal drugs no longer to work successfully. those drug interactions are viable, however do not continually arise. Your health practitioner or pharmacist can often save you or control interactions by means of changing how you use your medicinal drugs or with the aid of near tracking.To help your medical doctor and pharmacist come up with the high-quality care, make sure to tell your physician and pharmacist about all the goods you use (which includes prescription drugs, nonprescription pills, and natural products) earlier than starting remedy with this product. even as the use of this product, do now not begin, prevent, or change the dosage of some other drugs you are using without your health practitioner's approval.a few merchandise that can engage with this drug include: live bacterial vaccines, methotrexate.before taking amoxicillin, inform your medical doctor or pharmacist in case you are also taking probenecid. Probenecid slows down the elimination of amoxicillin from your body, inflicting better stages of this antibiotic to your bloodstream. For sure styles of tough-to-deal with infections, your health practitioner may additionally prescribe these 2 medications together so one can achieve this effect. seek advice from your physician or pharmacist for extra information.even though maximum antibiotics probably do not have an effect on hormonal start manipulate consisting of tablets, patch, or ring, some antibiotics may additionally decrease their effectiveness. this could motive being pregnant. Examples encompass rifamycins which includes rifampin or rifabutin. make certain to invite your medical doctor or pharmacist in case you have to use additional dependable birth manipulate methods at the same time as the usage of this antibiotic.Amoxicillin may additionally reason false wonderful outcomes with positive diabetic urine testing merchandise (cupric sulfate-kind). This drug may affect the results of positive lab tests. make sure laboratory employees and your docs recognize you use this drug.This record does no longer incorporate all possible drug interactions. hold a list of all the products you operate. percentage this list with your health practitioner and pharmacist to lessen your risk for serious medicine issues.
Amoxicillin Suspension- Overdose
If overdose is suspected, touch a poison manage middle or emergency room at once. US residents can name their community poison control middle at 1-800-222-1222. Canada citizens can name a provincial poison control center. symptoms and signs and symptoms of overdose can also include: excessive vomiting, chronic diarrhea, a extreme decrease in the quantity of urine, or seizures.
NOTES:
 Do now not percentage this remedy with others.This remedy has been prescribed for your modern-day circumstance most effective. Do not use it later for another contamination besides your health practitioner directs you to perform that. A specific medicinal drug may be crucial in that case.With prolonged remedy, laboratory and/or clinical checks (along side kidney and liver feature, entire blood counts) may be finished periodically to display screen your progress or take a look at for aspect consequences. seek recommendation out of your medical doctor for more information. Not noted DOSE: if you leave out a dose, use it as fast as you keep in mind. If it's miles near the time of the subsequent dose, skip the ignored dose and resume your common dosing agenda. Do not double the dose to trap up.
Garage:
 Refrigeration may also enhance the flavor of this medicine. positive brands of this medicine may additionally expire earlier while saved at room temperature than when refrigerated. take a look at the bottle or ask your pharmacist to appearance if (and for how lengthy) you may maintain this medicinal drug at room temperature. Do no longer save inside the toilet. keep all medicines far from youngsters and pets.Discard any unused component after 14 days because the drug loses efficiency after that point.Do no longer flush medicines down the rest room or pour them into a drain except told to reap this. nicely discard this product while it's miles expired or no longer wanted. seek advice from your pharmacist or community waste disposal company for greater details about the manner to efficiently discard your product.
0 notes
laurasmithme-blog · 5 years ago
Text
ACIVIR 400mg
DESCRIPTION
Acivir 400mg belongs to the group of medicines known as antivirals, which are required to treat infections caused by viruses.
Typically,these medicines work for only one type of virus infections. Acivir 400mg is also knowns as Acycloguanosine, Acivir 400mg  is a prescription drugs administrated orally which is used under the supervision of medical practioners. Acivir 400mg  is used with combination of other medications.
Tumblr media
Acivir 400mg is a type of nucleoside analogs (group of synthetic drugs), will inhibit the symptoms of infection contains Herpes Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV(varicella-Zoster virus) and thereby causes shingles and chickenpox.
INDICATION OF ACIVIR 400mg
Acivir 400mg is indicated to lowers the pain and rapid healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster. Acivir 400mg  is also indicated for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from time to time(genital herpes) and hence blocks the outbreaks of genital herpes in people affected by virus.
MECHANISM OF ACTION OF ACIVIR 400mg
Acivir isexcited by phosphorylation before to that drug will preventssynthesis ofviral DNA. Acivir changes by addition of phosphate group to a viral enzyme known as thymidine kinase has more affinity. HSV-TK or VZV-TK by phosphorylation converts into acyclovir triphosphate then combined into viral DNA, thereby stops further DNA synthesis.Since Acivir attack to a selective type of viral kinase, the drugs enter and works on those cells infected with HSV or VZV, hence it will demobilize the formation of herpesvirus DNA. At high concentration has low activity in uninfected cells, Here by HSV-TK or VZV-TK mutation will lead resistance to acyclovir.
Tumblr media
ADME PROPERTIES
ABSORPTION
bad water soluble, high plasma concentration after 1-2 hours and bioavailability 15-30%.
DISTRIBUTION
human serum protein binding is about 9 to 33%.
METABOLISM & ELIMINATION
half-life based concede to age group neonates have t1/2 is 4 hours, children’s have 2-3 hours and for adults t1/2 is 3 hours.
Tumblr media
DOSAGE
HERPES SIMPLEX- MUCOCUTANEOUS/ IMMUNOCOMPETENT HOST
The recommended adult dose is 400mg orally every 4 hours or 5 times a day for 10 days. Prescribed 400mg orally 3 times a day is givenfor 5 to 10 days.
FOR PEDIATRIC DOSE
less than 12 years patients prescribed 40 to 80mg/kg/day orally, it can be divided into 3 to 4 times a day, max 5 to 10 days Max dose is given up to 1000mg/day 12yrs or older of patients prescribed 400mg orally 5 times a day every 4 hour. 400mg orally 3 times a day Duration: 7 – 10 days
HERPES SIMPLEX - MUCOCUTANEOUS/ IMMUNOCOMPROMISED HOST
The recommended adult dose is 400mg orally 3 times a day Duration: up to 5 to 10 days The patient having Severe disease prescribed dose is 5mg/kg IV every 8 hours
For Episodic treatment: prescribed dose is 400mg orally 3 times a day upto 5 to 14 days For pediatric dose: <12 years: 10 mg/kg IV for every 8 hours upto 7 days 12 years or older: 5 mg/kg IV for every 8 hours upto7 days continues HIV infection The patients with Mild Symptomatic Gingivostomatitis:20 mg/kg orally 4 times a day for 7 to 10 days ; Maximum dose: 400 mg Moderate to Severe Gingivostomatitis:5 to 10 mg/kg IV 3 times a day
HERPES SIMPLEX ENCEPHALITIS
The usual adult dose is10mg/kg IV for every 8 hours Duration administrated for 10days and center for disease control and prevention recommends 21 days
For pediatric dose: 3 months to 12 years old : IV 10 to 20 mg/kg for every 8 hours 12 years or older: 10mg/kg IV every 8 hours Duration: 10days and center for disease control and prevention recommends 21 days
HERPES ZOSTER
The usual adult dose is 800mg orally every 4 hours ( 5 times a day) for 7 to 10 days Patients with Immunocompromised host dose is 10 mg/kg IV every 8 hours for 7 days Treatment Duration 7 to 14-day course (oral plus IV)
For pediatric the prescribed dose is Immunocompetent Host: -Parenteral: < 1 year: 10 mg/kg IV every 8 hours for 7 to 10 days 1 year or older: 500 mg/m2 IV every 8 hours for 7 to 10 days Oral: 12 years or older: 800 mg orally 5 times a day for 5 to 7 days Immunocompromised Host: 10 mg/kg IV every 8 hours for 7 to 10 days
OVERDOSAGE
Acivir 400mg tablet contains ingestion of 100 capsules ( 20g) have been resulted has agitation, coma, seizures and lethargy. If overdose occurs provide supportive measures.
DRUG INTERACTION
Acivir concomitant use with probenecid will reduce tubular secretion of acyclovir and increase the blood plasma and half- life of acyclovir. Interaction of Acivir with nephrotoxic drugs may cause increase the risk in renal function Interaction with immunostimulators will enhancing effects of acyclovir.
CONTRAINDICATION
Acivir is contraindicated in patients who causes hypersensitivity to acyclovir or valacyclovir.
Tumblr media
PRECAUTION
Acivir 400mg cause allergic reaction like breathing trouble, swelling of throat or tongue, rash, hives. Inform your doctor if symptoms occur. Discuss with your consultant about planning to become pregnant or pregnancy because drug can be used if possible benefits clarify possible risk to the patients. Discuss with doctor If you had kidney disease because the excretion of drug will not perform well, Acivir 400mg will decrease the kidney function.
PREGNANCY
Category B: In animal studies it has not shown harm to the fetus and In human no enough studies carried out in pregnant women to describe the harm to the fetus. Drug used only if possible benefits clarify possible risk to the patients.
CONTACT US
PHONE NO:+91 9940472902 
WEBSITE:https://pillsbag.com/products/acivir-400mg
0 notes
laurasmithme-blog · 5 years ago
Text
ACIVIR 200MG
DESCRIPTION
Acivir 200mg belongs to the group of medicines known as antivirals, which are required to treat infections caused by viruses.
Tumblr media
Typically,these medicines work for only one type of virus infections. Acivir 200mg is also knowns as Acycloguanosine, Acivir 200mg is a prescription drugs administrated orally which is used under the supervision of medical practioners. Acivir 200mg is used with combination of other medications.
Acivir 200mg is a type of nucleoside analogs (group of synthetic drugs), will inhibit the symptoms of infection contains Herpes Simplex Virus (HSV), this infection will cause herpes simplex or type of herpes virus VZV(varicella-Zoster virus) and thereby causes shingles and chickenpox.
INDICATION OF ACIVIR 200MG
Acivir 200mg is indicated to lowers the pain and rapid healing of sores or blisters which is caused by varicella (chickenpox), Herpes Zoster. Acivir 200mg is also indicated for the treatment of herpes virus infection which causes sore to form around the genitals and rectum from time to time(genital herpes) and hence blocks the outbreaks of genital herpes in people affected by virus.
Tumblr media
MECHANISM OF ACTION OF ACIVIR 200MG
Acivir isexcited by phosphorylation before to that drug will preventssynthesis ofviral DNA. Acivir changes by addition of phosphate group to a viral enzyme known as thymidine kinase has more affinity. HSV-TK or VZV-TK by phosphorylation converts into acyclovir triphosphate then combined into viral DNA, thereby stops further DNA synthesis.Since Acivir attack to a selective type of viral kinase, the drugs enter and works on those cells infected with HSV or VZV, hence it will demobilize the formation of herpesvirus DNA. At high concentration has low activity in uninfected cells, Here by HSV-TK or VZV-TK mutation will lead resistance to acyclovir.
ADME PROPERTIES
ABSORPTION
bad water soluble, high plasma concentration after 1-2 hours and bioavailability 15-30%.
DISTRIBUTION
human serum protein binding is about 9 to 33%.
METABOLISM & ELIMINATION
half-life based concede to age group neonates have t1/2 is 4 hours, children’s have 2-3 hours and for adults t1/2 is 3 hours.
Tumblr media
DOSAGE
HERPES SIMPLEX- MUCOCUTANEOUS/ IMMUNOCOMPETENT HOST
The recommended adult dose is 200mg orally every 4 hours or 5 times a day for 10 days. Prescribed 400mg orally 3 times a day is givenfor 5 to 10 days.
FOR PEDIATRIC DOSE
less than 12 years patients prescribed 40 to 80mg/kg/day orally, it can be divided into 3 to 4 times a day, max 5 to 10 days Max dose is given up to 1000mg/day 12yrs or older of patients prescribed 200mg orally 5 times a day every 4 hour. 400mg orally 3 times a day Duration: 7 – 10 days
HERPES SIMPLEX - MUCOCUTANEOUS/ IMMUNOCOMPROMISED HOST
The recommended adult dose is 400mg orally 3 times a day Duration: up to 5 to 10 days The patient having Severe disease prescribed dose is 5mg/kg IV every 8 hours
For Episodic treatment: prescribed dose is 400mg orally 3 times a day upto 5 to 14 days For pediatric dose: <12 years: 10 mg/kg IV for every 8 hours upto 7 days 12 years or older: 5 mg/kg IV for every 8 hours upto7 days continues HIV infection The patients with Mild Symptomatic Gingivostomatitis:20 mg/kg orally 4 times a day for 7 to 10 days ; Maximum dose: 400 mg Moderate to Severe Gingivostomatitis:5 to 10 mg/kg IV 3 times a day
HERPES SIMPLEX ENCEPHALITIS
The usual adult dose is10mg/kg IV for every 8 hours Duration administrated for 10days and center for disease control and prevention recommends 21 days
For pediatric dose: 3 months to 12 years old : IV 10 to 20 mg/kg for every 8 hours 12 years or older: 10mg/kg IV every 8 hours Duration: 10days and center for disease control and prevention recommends 21 days
HERPES ZOSTER
The usual adult dose is 800mg orally every 4 hours ( 5 times a day) for 7 to 10 days Patients with Immunocompromised host dose is 10 mg/kg IV every 8 hours for 7 days Treatment Duration 7 to 14-day course (oral plus IV)
For pediatric the prescribed dose is Immunocompetent Host: -Parenteral: < 1 year: 10 mg/kg IV every 8 hours for 7 to 10 days 1 year or older: 500 mg/m2 IV every 8 hours for 7 to 10 days Oral: 12 years or older: 800 mg orally 5 times a day for 5 to 7 days Immunocompromised Host: 10 mg/kg IV every 8 hours for 7 to 10 days
OVERDOSAGE
Acivir 200mg contains ingestion of 100 capsules ( 20g) have been resulted has agitation, coma, seizures and lethargy. If overdose occurs provide supportive measures.
DRUG INTERACTION
Acivir concomitant use with probenecid will reduce tubular secretion of acyclovir and increase the blood plasma and half- life of acyclovir. Interaction of Acivir with nephrotoxic drugs may cause increase the risk in renal function Interaction with immunostimulators will enhancing effects of acyclovir.
CONTRAINDICATION
Acivir is contraindicated in patients who causes hypersensitivity to acyclovir or valacyclovir.
Tumblr media
PRECAUTION
Acivir 200mg cause allergic reaction like breathing trouble, swelling of throat or tongue, rash, hives. Inform your doctor if symptoms occur. Discuss with your consultant about planning to become pregnant or pregnancy because drug can be used if possible benefits clarify possible risk to the patients. Discuss with doctor If you had kidney disease because the excretion of drug will not perform well, Acivir 200mg will decrease the kidney function.
PREGNANCY
Category B: In animal studies it has not shown harm to the fetus and In human no enough studies carried out in pregnant women to describe the harm to the fetus. Drug used only if possible benefits clarify possible risk to the patients.
CONTACT US
PHONE NO:+91-9940472902
WEBSITE:https://pillsbag.com/products/acivir-200mg
0 notes