#prevention effects

[magicjudge]

If I control a Ria Ovor, Bane of Bladehold and a Gisela, Blade of Goldknight, and I go to combat and target Gisela with Ria Ivor, how many mite tokens will I make when Gisela hits? Since they're both replacement effects do I get to pick the order they apply? Does this change if a third player controls the Gisela and I hit the second player with a different creature targeted by Ria Ivor?

The controller of Gisela is irrelevant here beyond which of her abilities applies to the damage being dealt, so she could be yours or another opponent's and the result would be the same.

So what is the result here? Unfortunately, it's the worst case scenario for you, or at least it's likely to be. Both Gisela's ability and Ria's ability affect the combat damage that the creature would deal to your opponent. When multiple replacement or prevention effects want to modify the same combat damage event, then the player being damaged (or the controller of the creature or planeswalker being damaged) gets to choose which effect gets applied first. In this case, they'll almost certainly choose to prevent the damage with Ria's ability first, leaving nothing for Gisela to double.

[reasonsforhope]

"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.

The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.

Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.

Tell us about the trial and what it set out to achieve

The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.

Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.

The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.

The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.

Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...

The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.

In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.

By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...

What is the significance of these trials?

This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.

There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...

For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.

HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.

For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.

What happens now?

The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.

They will be offered the choice of PrEP they would prefer as the trial continues.

A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.

It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.

How long until the drug is rolled out?

We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.

The World Health Organization will also review the data and may issue recommendations.

We hope then that this new drug will be adopted into WHO and country guidelines.

We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.

Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.

Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.

In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."

-via The Conversation, July 3, 2024

[biggest-gaudiest-patronuses]

dipping a large body of bread into hot stew and tearing off a chunk with your bared teeth is respectful and good. it shows the Earth we want to be here, and will fight to remain. our ancestors understood

[bigfatbreak]

Wait so, the way the peacock works now is whenever it is used, anyone Ladybug loves receives the side effects of using the peacock instead of the user themselves. So before Marinette met Adrien she didn’t have someone to love so the effects just went to her? And now that she fell for Adrien the effects are going to him?

:) yup!

[canisalbus]

Hello, I'm not sure if you're aware, but tumblr is going to start helping midjourney gather data for their AI. You're one of the artists I follow here pretty actively and I wanted to warn you to maybe start nighshading your art before posting it here so it doesn't get swept up!

I've seen a couple of posts about it. Feeling disappointed but not that surprised. Also not excited about having to start nightshading/glazing my pieces but if there isn't going to be any serious regulations regarding data scraping and ai "art", there aren't a lot of choices.

Thank you for taking the time to warn me just in case, it was very thoughtful of you!

[captainjonnitkessler]

I think I've identified the reason I get so worked up about anarchism in relation to labor rights and safety in particular.

Three years ago I watched my coworker almost die when a piece of machinery we were moving unsafely fell on him. It missed his head by an inch and snapped his leg in half instead. It took months of recovery and multiple surgeries for him to walk again and he will be disabled for the rest of his life. And it didn't happen because of Capitalism or profit motive or because our evil bosses were forcing us to work unsafely. It happened because he'd done similar things a hundred times before and it had always been fine, and because I didn't know enough to clock just how dangerous what we were doing was, and just because of some plain shitty luck. Mentally it fucked me up for months in ways I didn't recognize until well after the fact.

And the thing is, almost every construction worker can tell you about the time they saw a fatal or near-fatal accident. An apprentice younger than me had a heart attack and was out of work for over a year after shocking himself on a live circuit. The woman who runs our apprenticeship program has a husband who had his arm blown off in an arc flash incident. One of my teachers had a coworker die after getting hung up on a live circuit and he wasn't found until the end of the day.

Construction is one of the single most dangerous industries to work in, and I believe this is why rates of drug and alcohol abuse and suicide are sky-high in the industry. I think many construction workers are low-key traumatized by knowing constantly that they could die or be permanently disabled due to a very simple mistake or oversight. It is simply inherently unsafe when you are working with live electricity, power tools, heights, thousands of pounds of machinery, cranes, etc. And so yes, I do believe that safety protocols and the ability to enforce them are absolutely necessary to preventing a massive amount of death. The number of worker deaths in the US has been slashed by 60% since OSHA was instated.

And so to get online and have someone who has never set foot on a jobsite in their life condescendingly explain to me that actually, we don't need OSHA or the ability to enforce safety standards because in a perfect world everyone will just suddenly start working perfectly safely, and I'm just too stupid or brainwashed to realize that The Real Villain Is Capitalism, and if we just get rid of that it will somehow also get rid of the inherent safety issues involved in the entire construction industry - well it turns out it pisses me off a little bit!

[ariadne-mouse]

I mentioned in this post that I thought it would take a life or death choice about Imogen for Liliana to flip, situationally, as opposed to the party being able to convince her to change her ideology (cult juice is strong), and it seems we may have gotten an element of that in Liliana flying to Imogen's aid against Otohan. I'd be very curious what Liliana would have done if she'd gotten there in time to fight, but we'll never know, so we have to digest the moment we got. I also think FCG's death adds another dimension both in-game and above the table. Since we dropped out literally mid-scene after her arrival this post may get stale immediately after the first few minutes of next week's episode, but for now I think it's safe to say that at least for the time Liliana spends with the party right now she will not be an active antagonist. Her daughter called for help and she answered, and her first act was trying to comfort her. Matt also wouldn't hit the players with another big battle fresh off the first (and with that outcome), so if they do have to face Liliana as an enemy it would be later under evolved circumstances.

To be clear I don't think FCG dying means Matt nerfs the threat of Liliana or that this situation means she has flipped permanently, but rather, it neatly interrupts the established dynamic between Liliana and Imogen thus far and creates a chance for new dialogue that doesn't just repeat all the same things as before. Imogen hasn't needed her mother - not really - and maybe still doesn't, but she called for help and is grieving now and the conversation doesn't necessarily have to be the same old "Liliana renounce your cause" but rather "help your daughter here and now" and to connect with her through that emotion. This is probably the best opportunity they'll ever get to flip Liliana in a more than "last ditch in a crisis moment" kind of way or lay the groundwork for that happening later. Now, the party - and Imogen in particular - may rightly be angry with Liliana as an ally of Otohan, and that FCG died because of the cause Liliana supports. Liliana may want to comfort her daughter while also believing that FCG's death was unfortunate but not ultimately a reason to doubt the cause or escape what she sees as inevitable. It's messy! But it's a very interesting situation and FCG's death is such a visible wound on Imogen that it may elicit Liliana to do or consider things she wouldn't, otherwise.

[mooshroomterrarium]

Grian fell from a high place.

3rd Life (manga ver.) — End

[effervescentdragon]

i think a lot of people should google datenschutz/gdpr and how it protects people who bring in a complaint to their workplace/place of study before you start calling for the investigation to be published

[puppyeared]

i love augustas radiation/flea collar, especially how it matches her eyes!!

thank u!!!! it was either that, or the Cone of Shame lol

[thatdiabolicalfeminist]

Hiii I hope youre doing alright. <3 I remember you mentioning you use a certain mouth wash to help with covid protection and Im just wondering what mouth wash it was? Im not sure what ingredients to look for so I figured Id ask. Tysm for the help! I hope this isnt too annoying to respond to. 😅🙈

Hi I love asks like these bc I love sharing information and this is straightforward n easy to answer!! I hope you don't mind me answering publicly bc I think more people should know about this!!

Cetylpyridinium chloride (CPC) is the mouthwash ingredient that kills covid virus in the mouth and upper throat!

Ideally paired with other preventatives, it can drastically reduce risk since it reduces the amount of live virus at the point of infection. I use it right after being around people I don't live with, and during long events I have a travel bottle in my purse to refresh every couple hours. I use this mouthwash (under $4 for a big bottle): https://www.walmart.com/ip/Equate-Alcohol-Free-Multi-Action-Antiseptic-Oral-Rinse-Zesty-Mint-33-8-fl-oz/26441079

(If you end up buying it elsewhere, double check for "Cetylpyridinium chloride" in the active ingredients. Some search results are misleading.)

Nose sprays can also help mitigate covid risk: https://www.okdoomer.io/nose-sprays-offer-a-last-line-of-defense/?ref=ok-doomer-newsletter

Fun fact, even if you DO get covid, studies have shown the fewer virus particles you're exposed to when you first get infected, the less severe the infection itself is likely to be for you!!

[briarpatch-kids]

I hate how society is so fat phobic that people will question why someone with t2 diabetes needs a medication to control blood sugar more than their need to lose weight. Like maybe, just maybe, having an uncontrolled blood sugar of 300 is just a little more dangerous than you potentially having health problems years down the line. One is decidedly more dangerous.

[cluescorner]

Arlecchino's whole deal is unbelievable

Arlecchino: Huh I wonder what's causing my weird powers? I can't really worry about that right now tho, I've gotta become King and then kill my "Mother".

*Kills Clervie and "Mother"*

Arlecchino: Huh I wonder why I was able to defeat a Fatui Harbinger when I'm like 17 or so? I can't really worry about that right now tho, I've gotta be in jail and become a Harbinger.

*Is in jail for a while and becomes a Harbinger*

Arlecchino: Huh I wonder why I am-

Pierro: Hey what's up hello, anyways you're descended from the Crimson Moon Dynasty of Khaenri'ah. I'm sure that this is a lot for you to take in so-

Arlecchino: Ok.

Pierro: ...You're just cool with that?

Arlecchino: IDK maybe? I can't really worry about that at the moment, I'm a father now. This orphanage full of children I love (who also are child soldiers and are not allowed to leave or else I'll execute them except maybe now I'm just gonna wipe their memories IDK I'm morally complex) isn't gonna run itself.

*Runs the orphanage/spy recruitment initiative*

Me, the fucking player: WHAT DO YOU MEAN YOU ARE KHAENRI'AN? WHY WASN'T THIS BROUGHT UP IN YOUR FUCKING QUEST?? OR ANYTHING ELSE????

Arlecchino, talking to me through my phone: I honestly don't know why you care, I'm too busy to give a shit. Anyways, I'm gonna go fight fate itself I guess. I'm sure that I don't share any thematic parallels with any other Khaenri'an characters (particularly as it relates to acting and family angst) and that I haven't made the idea of 'curses' on Khaenri'ans and what they entail even more complicated than they already were. See ya.

[inksandpensblog]

Sorry but I'm still thinking about this: if Chosen really "wasn’t holding back" then Glasses would be dead. He’d either die from the cold or from lack of air or from electrocution.

By the time this moment happens, Chosen's lightning has already shorted out the other three jetskis (and I reiterate, his lightning seems to have only struck the jetskis, not their riders), leaving the other three mercs incapable of reaching him. With that one strike, he turned this encounter from a 4v1 into a 1v1.

Glasses has no backup, here. He's lost the advantage of numbers, the biggest advantage his team had, and he's taking on Chosen alone.

Why do I say that numbers were the team's biggest advantage, when Glasses still has his jetski with its glitch-shots?

Because those aren't much of an advantage if Chosen decides to just tank every single shot and power through the aftereffects regardless.

Whether this was a...smart decision on Chosen's part is up for debate, but the end result is that Chosen has nullified both of Glasses' advantages against him. Glasses never pulls out his toolbar until after he's landed on the ground and disembarked from his ride, most likely because he can't wield it effectively up in midair.

The only reason I can think of for Chosen to do something as foolhardy as not dodging the glitch-shots is because he wanted his landing to be as accurate as possible, so he didn't do anything that would alter his fall-path.

With how big his glacier ends up, he could've aimed in Glasses' general direction and it still would've worked. He didn't have to be accurate.

But no, Chosen gets close enough for a point-blank attack.

So again, if he wasn’t holding back, tell me how Glasses is still alive right now??

He and Glasses are practically nose-to-nose, when Chosen strikes.

He didn't have to miss.

--

I still have to analyze Chosen's behavior in this episode as a whole, and I still have to compare it with his behavior in past episodes; but in this opening scene I am absolutely certain that he was going out of his way to avoid hurting his pursuers. To his own detriment, even.

Just because he “went all-out with his powers” doesn’t mean he wasn’t holding back. I’d even argue that he wouldn’t have had to go all-out with his powers if he’d decided that killing or crippling the mercs was okay.

Because, like I said, he could've ended Glasses right there.

[ardentpoop]

[cleradinel]

when noah says he got scolded for talking about st5 this is all i can think about