#pipette tips

[cotaus-biomedical]

16 strict quality control measures ensuring precision pipetting performance in pipette tip production.

At Cotaus, we understand that the accuracy and reliability of laboratory results depend on the precision of every tool used. That’s why our pipette tips are produced under the strictest quality control standards, ensuring they meet the highest performance benchmarks for accurate pipetting. From the selection of materials to the final inspection, every step of the production process is carefully monitored to guarantee consistency, durability, and precision. Let's see How we do.

1. Tips' volume accuracy and precision

Cotaus each batch of pipette tips undergoes volume calibration to ensure they fall within the standard tolerance range. Random samples are taken from each batch and multiple liquid aspirates and dispenses are performed to check the consistency of the tip’s volume accuracy and precision.

2. Tips' dimensional consistency

Random samples are taken from each batch to test the tip’s dimensions to ensure they conform to standard specifications(Uniformity of product dimension≤0.15), ensuring consistent inner and outer diameters, length and shape to prevent fit issues.

3. Tips' physical integrity

The tips are checked for cracks, air bubbles, or any physical defects that might affect their pipetting performance or lead to contamination.

Pressure and bend tested to ensure they can withstand normal operating pressure and bending without breaking or deforming.

4. Tips' airtight seal and fit

Verifying that the pipette tips fit securely onto pipettes or automatic liquid handling platform, ensuring no air leakage during aspiration or dispensing. Ensure the tips are compatible with various pipette brands and robotic liquid handling systems, ensuring no loosening, slipping, or improper fit.

5. Tips' concentricity

Using precision instruments such as laser scanners or coordinate measuring machines (CMM), to check the roundness of both the inner and outer diameters. Cotaus pipette tips require concentricity errors within ±0.2 mm.

6. Tips' perpendicularity

Using specialized perpendicularity testing instruments to check the angle between the tip's bottom surface and its central axis. The error is typically required within a tolerance of 0.5 millimeters or less.

7. Tips' liquid retention and low-residue testing

Special surface treatments are applied to ensure the inner surface of the tip is smooth and reduces liquid retention, especially when handling viscous liquids. Measurement of liquid residue left in the tip after aspiration and dispensing, particularly when handling small volumes, to ensure minimal liquid carryover.

8. Tips' retention force

Measuring the force required to attach and detach the pipette tips, ensuring they are neither too tight (difficult to remove) nor too loose (which could cause aspiration issues).

9. Tips' surface smoothness

Ensures that both the inside and outside surfaces of the tips are smooth, with no irregularities or roughness, testing for smooth internal and external surfaces to minimize sample retention, avoid contamination, and enhance the efficiency of liquid transfer.

10. Tips' sterility

Ensures that sterile tips are sealed properly during packaging to prevent contamination. Cotaus disposable tips utilize electron beam sterilization which is a safe and efficient method that leaves no chemical residue.

11. Tips' resistance and CV values

Resistance testing ensures the durability and performance of the pipette tip under different physical and chemical conditions. CV testing evaluates the precision of liquid transfer by measuring the consistency of the tip’s performance, ensuring high accuracy and low variability.

12. Tips' material durability

Adopt imported medical-grade polypropylene (PP) materials to ensure the dimensional stability of the tips, Cotaus ensures consistency in the material used to avoid discrepancies in dimensions or performance that could affect pipette accuracy.

13. Tips' manufacture equipment

Cotaus owns 120+ automated manufacturing assembly lines, using high-precision injection molding machines to ensure dimensional consistency and accuracy of the tips, improving efficiency and reducing human error.

Cotaus owns a mold manufacturing company that produces high-precision molds for pipette tip production, ensuring accurate shape, size, concentricity, and perpendicularity.

Quality control equipment including precision balances and measuring devices, laser measurement instruments, automated inspection systems, etc.

14. Tips' production environment

Manufactured in a 100000-class dust-free workshop to avoid contamination from dust, particles, or contaminants.

15. Tips' QC Standards

Ensures the tips comply with quality standards (ISO13485, CE, FDA), guaranteeing their performance, precision, and reliability.

16. Tips' production process management

ERP Systems manage raw materials, production scheduling, inventory, and shipping, ensuring a smooth and timely production process. Critical production parameters and quality inspection data are recorded and stored during production, providing traceability for each batch of tips and facilitating post-production quality tracking.

[microlitseo]

Liquid Handling in Drug Discovery: Enhancing Precision and Throughput

Liquid handling is a critical process in drug discovery, involving the accurate and efficient transfer of liquids between containers. The precision and throughput of liquid handling operations can significantly impact the success of drug discovery research. In this blog post, we will explore the importance of precision liquid handling in drug discovery and discuss some of the key technologies and techniques that are used to enhance precision and throughput. 

The Importance of Liquid Handling in Drug Discovery

Liquid handling is a fundamental aspect of drug discovery research, with applications ranging from compound screening and formulation to analysis and quality control. Accurate and precise liquid handling is essential for: 

Ensuring data reliability: Inconsistent liquid handling can lead to errors in experimental data, compromising the validity of research findings.

Improving efficiency: Efficient liquid handling techniques can accelerate the drug discovery process and reduce costs.

Enhancing reproducibility: Consistent liquid handling practices are crucial for ensuring reproducibility of experimental results.

Liquid Handling Technologies

A variety of liquid handling systems are available to researchers, each with its own advantages and limitations. Some of the most commonly used technologies include:

Manual pipettes: While still widely used, manual pipettes can be time-consuming and prone to human error.

Electronic pipettes: Automated pipetting systems offer improved accuracy and precision compared to manual pipettes, as well as features such as adjustable pipetting speeds and programmable protocols.

Liquid handling workstations: Automated liquid handling workstations can significantly increase throughput and reduce the risk of human error. These systems can be programmed to perform complex liquid handling tasks, such as serial dilutions, transfers, and aliquoting.

Techniques for Enhancing Precision and Throughput

In addition to selecting the appropriate liquid handling technology, researchers can also employ a number of techniques to enhance precision and throughput:

Tip calibration: Regular calibration of pipette tips is essential for ensuring accurate liquid handling.

Liquid handling robotics: Automated liquid handling robots can be used to perform repetitive tasks with high precision and speed.

Miniaturization: Reducing the volume of liquid handled can improve efficiency and reduce costs.

Microfluidics: Microfluidic devices can enable high-throughput liquid handling with minimal sample volumes.

Conclusion

Liquid handling is a critical process in drug discovery that requires precision, accuracy, and efficiency. By selecting the appropriate technologies and techniques, researchers can enhance the quality and speed of their work, ultimately accelerating the development of new drugs.

[accumax]

Different Types of Pipette Tips and When to Use Them

Like deciding what to wear for the day, walking into a laboratory means you have to choose the right pipette tips for your experiments. This is about precision in avoiding mistakes and contamination rather than personal preferences when working in a lab. There are various types of tips, each designed with a specific application in mind.

Below is an ultimate guide on how to make sense of different kinds of pipette tips and their uses.

1. Non-Sterile vs. Sterile Tips

Non-Sterile Tips: These can be used for general laboratory procedures where sterility is not necessary. Using non-sterile tips may save money if you are dealing with non-sensitive samples or performing routine tasks.

Sterile Tips:

Required when doing tests where contamination would lead to compromised results, such as in microbiology, molecular biology or clinical settings. Such tips are pre-sterilized and certified free from contaminants like RNase, DNase, endotoxins etc. Although it might seem appealing to autoclave non-sterile tips onto sterile ones, inconsistent outcomes may occur because autoclaving does not have quality control measures.

2. Filter Tips

Filter Tips They are designed in such a way that prevents aerosols and liquids from entering the pipette body and thus safeguarding your samples as well as the pipette. Whenever you are dealing with volatile substances, corrosives or infectious materials it is important to use them. In some cases like PCR experiments where there is risk of contamination leading to false results, presence of filter tips is compulsory.

3. Long Tips

Long tips can get to the bottom of narrow tubes and deepwell plates without causing contamination towards the pipette’s shaft. In case you are working in a laboratory where you transfer liquids from tall containers, it is advisable to use long tips that maintain sterility and accuracy.

4. Short Tips

If you have short tips, ergonomic pipetting will be made possible, and hence there will be less strain on your arm or hand especially if you are using small well plates or multichannel pipettes. By sitting closer to the bench, they ensure exact pipetting making them the best for such fast robots.

5. Low Retention Tips

Low retention tips refer to those that comprise of special polypropylene blend or else coated with a hydrophobic surface intended for minimizing liquid retention. It is particularly essential when handling viscous or low surface tension liquids like concentrated protein or DNA solutions; this kind of tips ensures maximum sample recovery as well as accurate pipetting which may influence sensitive assays.

6. Wide Bore Tips

In delicate specimens like cell suspensions, standard ones can shear cells mainly due to their small opening; while wide bore tips have bigger holes thus providing easy passage for the solution through them hence preventing damage among other things when dealing with delicate samples such as cells in suspension or very thick liquids.

What Counts Concerning Quality and Fit

Quality of the tips that you get is as important as choosing the right type of tip for your pipette. This is because, by selecting poorly fitting or low quality tips, you risk taking inaccurate measures, adding to the strain of pipetting and contaminating samples in the process. Thus, it is advised that a high-quality tip should be compatible with your pipette for better outcomes and accurate results. Keep in mind therefore, how well the tips fit into your pipette so as to ensure consistency in lab work.

The importance of selecting the correct pipette tip does not depend on someone’s liking but rather impacts on getting reliable results. In order to ensure successful and efficient lab work it is necessary to identify various types of pipette tips and their applications. This blog originally posted here:  Different Types of Pipette Tips and When to Use Them

[liquidhandlingproduct]

Optimize Your Lab with Microlit's Precision Pipette and Filter Tip Box

Experience unparalleled precision with Microlit's Low Retention Pipette and Filter Pipettor Tip Box, designed for minimal sample loss and contamination prevention. This user-friendly, cost-effective solution is ideal for teaching labs, ensuring time and resource savings. Praised by experts like Elly York for its efficiency, Microlit enhances your lab's performance. Get yours today and transform your liquid handling tasks!

See more https://www.microlit.us/product-category/micropipette-tips/

[songhai1010597]

Universal Pipette Tips In Laboratory Applications

The choice of pipette tips is a critical consideration that directly influences the accuracy, precision, and reliability of liquid handling processes. Among the various options available, Filter Pipette Tips and Universal Pipette Tips have gained prominence for their distinct advantages in addressing specific challenges associated with pipetting.

Filter Pipette Tips are equipped with a barrier, often made of hydrophobic material, situated at the end of the tip. This design offers several advantages, making Filter Pipette Tips particularly advantageous in applications where contamination prevention is paramount.

Aerosol Containment:

The primary benefit of Filter Pipette Tips lies in their ability to prevent the aerosolization of liquids during pipetting. The hydrophobic filter acts as a barrier, trapping any liquid that may be drawn into the pipette tip during aspiration. This is particularly crucial when working with biohazardous or volatile substances, minimizing the risk of sample contamination and exposure.

Reduced Cross-Contamination:

Filter Pipette Tips contribute to the aseptic technique by reducing the risk of cross-contamination between samples. The hydrophobic filter prevents liquids from reaching the pipette shaft, ensuring that only the intended sample is aspirated. This is essential in applications such as PCR, where even trace amounts of contamination can impact the reliability of results.

[labpotato]

Me singing to the tube I’m trying to pipette from.

[fakebloodcapsule]

everytime i set up a qpcr plate im faced with the question of if i can count to six and then eight. then i am forced to face the fact that no. i can't.

[hunters-angel]

tomorrow i'm working with a new research group for the first time, i am vibrating with anxiety

[fungi-maestro]

Lab season once again so that means it's time to draw the horrible slug that I can hear whispering in my ear when I fuck up my work

[cotaus-biomedical]

Cotaus Robotic Pipette Tips Compatible with the following robotic systems: Agilent, Tecan, Hamilton, Beckman, Xantus, Apricot Designs.

Features:

Made of high quality polypropylene(PP)

Color: black(Conductive), clear

Sterile or non-sterile

Filtered or non-filtered

Standard or extended length

DNase/RNase free, Pyrogen free, Bioburden free, PCR inhibitor free, or endotoxin free

Low CV Accuracy, strong hydrophobicity, no liquid adhesion

[microlitseo]

In the realm of laboratory equipment, even the smallest components can significantly impact experimental outcomes. One such crucial component is the pipette tip. Often overlooked, the type of pipette tip used can influence the accuracy, precision and integrity of experimental results. Among the choices available, two main types stand out: Ordinary and Filtered pipette tips. Understanding their differences and when to use each is essential for any researcher striving for reliable and reproducible data.

[accumax]

Different Types of Pipette Tips and When to Use Them

Master the art of precision with the right pipette tips! From sterile to non-sterile and low retention to filter tips, our guide helps you select the ideal tips for your lab work, ensuring accuracy and contamination-free results.  Improve your experiments’ outcomes by choosing the right pipette tips. Visit Accumaxlab now!

[liquidhandlingproduct]

Optimize Your Lab with Microlit's Precision Pipette and Filter Tip Box

Experience unparalleled precision with Microlit's Low Retention Pipette and Filter Pipettor Tip Box, designed for minimal sample loss and contamination prevention. This user-friendly, cost-effective solution is ideal for teaching labs, ensuring time and resource savings. Praised by experts like Elly York for its efficiency, Microlit enhances your lab's performance. Get yours today and transform your liquid handling tasks!

See more https://www.microlit.us/product-category/micropipette-tips/

[shroomsnail]

no matter where i am, if i have to do any type of writing under pressure from an upcoming deadline, i WILL preferentially clean or organise the space in which i am currently existing.

[notebook-enthusiast]

i can be so normal about people sharing my workspace ❤️ it's totally fine if you move everything i had carefully organized and leave a mess ❤️ i will not get upset ❤️

[vully-andthegoose]

my favorite thing about tlou episode 7 is when they’re at the college and ellie is poking around and says “there were definitely doctors here” and she’s looking at…an open (miraculously unspilled, like all 96 are still in there, HOW) box of pipette tips under a weird magnifying glass thing