#pharmaceutical preparation

[chemxpert]

The Vital Role of the Agrochemical Industry | Chemxpert Database

The agrochemical industry is a critical sector that supports global agricultural productivity by providing essential chemicals used in farming. These chemicals include pesticides, herbicides, fertilizers, and other products designed to protect crops from pests, diseases, and weeds, as well as to enhance soil fertility. This blog will delve into the various aspects of the agrochemical industry, exploring its importance, key components, and the role of databases in maintaining and improving industry standards.

[unicodehealthcareservices45]

[laboratory-equipment-supplier]

Advanced Pharmaceutical Testing Solutions by Gaia Science

In the pharmaceutical industry, stringent testing and quality control are essential to ensure that drugs are safe, effective, and meet regulatory requirements. The processes involved in testing and preparing pharmaceutical products play a significant role in ensuring that they deliver the desired therapeutic outcomes. Key elements in this process include dissolution testing, automated sample preparation, physical testing, and various specialized services. Gaia Science, a leader in providing advanced scientific solutions, offers a comprehensive range of equipment and services to meet the diverse needs of pharmaceutical companies. With a commitment to innovation and precision, Gaia Science is a trusted partner in pharmaceutical development and quality control.

Dissolution Testing: Ensuring Drug Efficacy and Safety

Dissolution testing is crucial in evaluating how a drug releases its active ingredients in the body. It provides insight into the rate and extent of drug absorption, which affects bioavailability and therapeutic effectiveness. Regulatory bodies like the FDA and EMA require detailed dissolution profiles for oral dosage forms to ensure that they meet the required standards for safety and efficacy.

Gaia Science provides a wide range of dissolution testing solutions, including:

• Fully-Automated Dissolution Tester: Designed for maximum efficiency, this system automates every aspect of dissolution testing, from sampling to analysis. It ensures high throughput and minimal human intervention, making it ideal for large-scale operations.

• Semi-Automated Dissolution Tester: Offers a balance between automation and manual control, allowing flexibility while still ensuring reliable results.

• Manual Dissolution Tester: For laboratories that require hands-on control, this option allows for precise manual operation, suitable for smaller-scale testing needs.

• Offline Dissolution Tester: Designed for labs that process samples offline, providing flexibility in workflow and sample management.

• UV Online Dissolution Tester: This advanced system uses UV detection to provide real-time analysis of dissolution samples, ensuring immediate feedback on drug release rates.

• UV On-/Offline Dissolution Tester: A versatile option that allows laboratories to switch between online and offline modes, providing greater flexibility in how samples are analyzed.

By offering these tailored solutions, Gaia Science ensures that pharmaceutical companies can choose the appropriate dissolution testing equipment based on their specific needs, improving testing efficiency and accuracy.

Automated Sample Preparation: Precision and Efficiency

Automated sample preparation is becoming an indispensable part of pharmaceutical analysis. With growing demands for faster and more accurate results, automation has become a key driver of efficiency and reproducibility in laboratories.

Gaia Science offers advanced automated sample preparation systems that streamline the preparation process for pharmaceutical analysis. These systems are capable of handling multiple tasks, including dilution, filtration, extraction, and mixing, which are essential in preparing samples for further testing. By automating these steps, Gaia Science’s solutions reduce the likelihood of human error, improve repeatability, and enhance laboratory throughput.

For pharmaceutical laboratories, these automated systems save time, lower costs, and ensure consistent, high-quality data. With modular designs, Gaia Science’s systems can be customized to meet specific testing requirements, making them versatile for a wide range of applications.

Physical Testing: Ensuring Product Integrity

The physical properties of pharmaceutical products are just as important as their chemical composition. Physical testing ensures that drugs can withstand the physical rigors of manufacturing, packaging, transportation, and storage while maintaining their efficacy. From tablets to capsules, each dosage form requires specific physical characteristics to ensure proper function.

Gaia Science offers a wide range of physical testing equipment, including:

• Friability Tester: Measures the tendency of tablets to break or crumble during handling and transportation. Ensuring tablets remain intact is critical for maintaining dosage accuracy.

• Tablet Disintegration Tester: Determines how quickly a tablet disintegrates in the body, a key factor in ensuring that the active ingredients are released at the correct rate.

• Tapped Density Tester: Measures the bulk density of powders to ensure consistent dosing and formulation.

• Cap Torque Tester: Tests the torque strength of bottle caps to ensure proper sealing and ease of opening by consumers.

• Hardness Tester: Evaluates the hardness of tablets to ensure they are strong enough to resist breaking, yet soft enough to disintegrate appropriately in the digestive system.

• Capsule Filler: Ensures consistent filling of capsules with active ingredients and excipients, ensuring uniform dosage across batches.

• Rotary Tablet Press: Used in tablet manufacturing to ensure that each tablet is compressed to the correct specifications.

• Weight Tester: Measures the weight of individual tablets or capsules to ensure consistency in dosage.

• Powder Flow Tester: Assesses the flow properties of powders to ensure they can be processed consistently during manufacturing.

These physical testing instruments from Gaia Science ensure that pharmaceutical products meet industry standards for quality and performance, preventing issues that could compromise the safety or efficacy of the drugs.

Comprehensive Pharma Services: Supporting Pharmaceutical Excellence

In addition to offering a range of advanced testing equipment, Gaia Science provides comprehensive pharmaceutical services to support every stage of the drug development and manufacturing process. These services include:

• Pharma Services: Gaia Science offers installation, calibration, validation, and maintenance services for all its equipment. Ensuring that laboratory instruments are properly calibrated and validated is essential for regulatory compliance and accurate results. Gaia Science’s team of highly trained professionals provides on-site support to ensure that all equipment is functioning optimally and meets the stringent standards required in pharmaceutical production.

• Training and Technical Support: Gaia Science provides comprehensive training and technical support to ensure that lab personnel are fully equipped to operate the equipment efficiently. Their experts work closely with clients to customize solutions that meet the specific needs of their operations.

• Customized Solutions: With a deep understanding of the pharmaceutical industry, Gaia Science offers customized solutions that cater to the unique needs of each laboratory. Whether it’s a small research lab or a large-scale manufacturing facility, Gaia Science tailors its products and services to provide maximum value.

Why Choose Gaia Science?

Gaia Science has established itself as a trusted partner for pharmaceutical companies looking for high-quality, reliable testing equipment and services. Their state-of-the-art technology, combined with unmatched customer support, ensures that pharmaceutical laboratories can meet the highest standards of quality and regulatory compliance. By offering innovative solutions in dissolution testing, automated sample preparation, and physical testing, Gaia Science helps companies streamline their processes and improve the accuracy of their results.

Conclusion

Dissolution testing, automated sample preparation and physical testing are essential processes in the pharmaceutical industry, ensuring that drugs are safe, effective, and of high quality. With Gaia Science’s advanced equipment and comprehensive services, pharmaceutical companies can confidently meet the demands of regulatory bodies while optimizing their workflows. Gaia Science’s commitment to innovation, precision, and customer support makes them a leader in providing scientific solutions to the pharmaceutical industry.

In Order To Find Out More Details On Scientific Laboratory Equipment Please Be Touch With Us Today Onwards..!

[asence]

Reach out to Asence Inc. for inquiries, partnerships, or more information about our pharmaceutical products and global distribution network. Get in touch today!

[zerinta]

At MediMatrix, we combine innovation with compassion to redefine healthcare. Explore our comprehensive product line and witness the difference.

[paulrpalmer111]

Pharmaceutical Training in Uk

Workers who receive Pharmaceutical Training in Uk from certified experts are more invested in their jobs and make more significant efforts to succeed in the area. They have learned to take charge of their technical duties and constantly improve to safeguard public health.

[reasonsforhope]

"The Biden Administration last week [early December, 2023] announced it would be seizing patents for drugs and drug manufacturing procedures developed using government money.

A draft of the new law, seen by Reuters, said that the government will consider various factors including whether a medical situation is leading to increased prices of the drug at any given time, or whether only a small section of Americans can afford it.

The new executive order is the first exercise in what is called “march-in-rights” which allows relevant government agencies to redistribute patents if they were generated under government funding. The NIH has long maintained march-in-rights, but previous directors have been unwilling to use them, fearing consequences.

“We’ll make it clear that when drug companies won’t sell taxpayer funded drugs at reasonable prices, we will be prepared to allow other companies to provide those drugs for less,” White House adviser Lael Brainard said on a press call.

But just how much taxpayer money is going toward funding drugs? A research paper from the Insitute for New Economic Thought showed that “NIH funding contributed to research associated with every new drug approved from 2010-2019, totaling $230 billion.”

The authors of the paper continue, writing “NIH funding also produced 22 thousand patents, which provided marketing exclusivity for 27 (8.6%) of the drugs approved [between] 2010-2019.”

How we do drug discovery and production in America has a number of fundamental flaws that have created problems in the health service industry.

It costs billions of dollars and sometimes as many as 5 to 10 years to bring a drug to market in the US, which means that only companies with massive financial muscle can do so with any regularity, and that smaller, more innovative companies can’t compete with these pharma giants.

This also means that if a company can’t recoup that loss, a single failed drug can result in massive disruptions to business. To protect themselves, pharmaceutical companies establish piles of patents on drugs and drug manufacturing procedures. Especially if the drug in question treats a rare or obscure disease, these patents essentially ensure the company has monoselective pricing regimes.

However, if a company can convince the NIH that a particular drug should be considered a public health priority, they can be almost entirely funded by the government, as the research paper showed.

Some market participants, in this case the famous billionaire investor Mark Cuban, have attempted to remedy the issue of drug costs in America by manufacturing generic versions of patented drugs sold for common diseases."

-via Good News Network, December 11, 2023

[cmibloggers]

Global Colonoscopy Bowel Preparation Drugs Market Is Estimated To Witness High Growth Owing To Increasing Demand for Accurate Diagnosis

The global Colonoscopy Bowel Preparation Drugs market is estimated to be valued at US$ Mn in 2022 and is expected to exhibit a CAGR of 4.9% over the forecast period, as highlighted in a new report published by Coherent Market Insights.

A) Market Overview:

Colonoscopy bowel preparation drugs are used to cleanse the colon before a colonoscopy procedure. These drugs help in emptying the bowel and provide better visualization of the colon during the procedure. The need for bowel preparation drugs is associated with the accuracy of diagnosis during colonoscopy, as a clean bowel allows for better detection of abnormalities such as polyps or cancerous growths. Regular screening and early detection of colorectal cancer have become crucial in reducing the mortality rate associated with this disease. Therefore, the demand for colonoscopy bowel preparation drugs is expected to increase significantly in the coming years.

B) Market Key Trends:

One key trend observed in the Colonoscopy Bowel Preparation Drugs market is the increasing preference for low-volume bowel preparation drugs. These drugs require a smaller volume of liquid intake and offer similar efficacy compared to traditional high-volume preparation drugs. Low-volume bowel preparation drugs are more convenient for patients as they cause less discomfort and are easier to consume. For instance, products like Plenvu by Ferring B.V. and Trilyte by Braintree have gained popularity due to their low-volume formulation. This trend is expected to drive the growth of the market as more patients opt for these alternatives.

C) PEST Analysis:

- Political: The political landscape plays a vital role in shaping healthcare policies and regulations related to the availability and affordability of colonoscopy bowel preparation drugs. Government initiatives promoting preventive healthcare and increasing awareness about colorectal cancer screening are expected to drive market growth.

- Economic: The economic factors influencing the market include the affordability of colonoscopy procedures, reimbursement policies, and the overall healthcare expenditure of a region. An increase in disposable income and better reimbursement coverage can contribute to the market's growth.

- Social: The social factors influencing the market include the prevalence of colorectal cancer, awareness about the importance of early detection, and the willingness of individuals to undergo colonoscopy procedures. Social campaigns and educational programs can play a significant role in increasing the adoption of bowel preparation drugs.

- Technological: Technological advancements in colonoscopy procedures, such as the development of advanced endoscopes and imaging technologies, have improved the accuracy of diagnosis. These advancements require effective bowel preparation drugs to ensure optimal visualization and accurate detection of abnormalities.

D) Key Takeaways:

1: The global Colonoscopy Bowel Preparation Drugs Market is expected to witness high growth, exhibiting a CAGR of 4.9% over the forecast period, due to increasing demand for accurate diagnosis during colonoscopy procedures. Proper bowel preparation is essential for better visualization and detection of abnormalities.

2: The Asia Pacific region is expected to be the fastest-growing and dominating region in the Colonoscopy Bowel Preparation Drugs market. This can be attributed to a large population base, rising prevalence of colorectal cancer, increasing awareness about preventive healthcare, and improving healthcare infrastructure.

3: Key players operating in the global Colonoscopy Bowel Preparation Drugs market include Ferring B.V., Bayer AG, Braintree, Bausch Health Companies Inc., and Norgine B.V. These companies are focusing on strategies such as product innovations, partnerships, and geographical expansions to gain a competitive edge in the market.

In conclusion, the global Colonoscopy Bowel Preparation Drugs market is set to experience significant growth due to the increasing demand for accurate diagnosis during colonoscopy procedures. The market is driven by the need for better visualization of the colon and the rising prevalence of colorectal cancer. Low-volume bowel preparation drugs are gaining popularity due to their convenience and efficacy. The Asia Pacific region is expected to witness high growth in the market, with key players focusing on product innovations and partnerships to stay competitive.

[wemahesh]

Openings for Drug Inspector (55 Posts) in Public Service Commission

The history of Constitution of India reveals that the concept of conducting competitive examination for appointment to certain posts came into consideration way back in the year 1853 and a committee for giving shape to that was constituted under the chairmanship of Lord Macaulay in the year 1854. Later on the Federal Public Service Commission and the State Public Service Commissions were…

[curarems]

Good news: I am finally getting Making Money this week! Bad news: the worst part of my exams officialy falls on 25th of May. My first 25th of May in Discworld fandom and I'll spend it as the last and worst day of my exams. Is this what being cursed feels like.

[raven-at-the-writing-desk]

Quick world lore question; does the game ever specify what kind of potions/poisons exist in twst? Like, since it's technically a fantasy world, would things like health/stamina potions like you'd see in rpg's exist? Or would it be closer to reality, like home remedies and basic pharmaceutical stuff?

I'm only an EN player and I havent read all the pomfiore student's vignette's so if they answer this there then im sorry for the bother ; ;

Potions aren't talked about in the only Pomefiore students' vignettes! (In fact, if we're talking just strictly Labwear vignettes... Vil and Rook's don't really focus on potions at all; only Epel's sort of does.) There isn't actually a ton of lore about potions, and in the times when they do become relevant, the writing tends to focus more on the ingredients and/or the preparation process rather than what kind of potion would be produced. For example, the entire Labwear series of vignettes frequently brings up rare or dangerous plants that require the application of magic in order to safely harvest, such as the mandrake and the lantern blossom.

I wasn't able to check all vignettes (since that would be like... what, probably a few hundred at this point? If not that, then at least over 100.), but there's definitely mentions of potions with various effects. From all lab vignettes alone and combing through the main story, here's what I could glean:

transformation/transmutation potions (prologue, book 2, Beans Day, book 6, etc; this is probably the most often mentioned type of potion)

voice-changing potions (Leona Labwear vignette)

color-changing potions (Epel Labwear voice line)

plant growth potions (Epel Labwear voice line)

sleeping potions (Silver Labwear vignette)

awakening potions (Silver Labwear vignette)

magic enhancing potions (book 2)

breathing underwater potions (book 3)

a potion that changes one part of your body to that of an animal's (book 3)

itch-relief potion (Lost in the Book with Stitch)

potion that heals burns instantly (Jamil Labwear vignette)

On the subject of poisons, no specific kinds are mentioned as far as I'm aware. There's a Poison Refining class (Cater Labwear vignettes), but we don't really get specifics. When poisons are talked about, it's usually in reference to the Fairest Queen or the Pomefiore dorm leader being skilled in making potent poisons, or it's Kalim talking about the many attempts on his life and unnamed poison antidotes. There may be more mentioned in other places, but at this time I don't have the capacity to check every single event and vignette. If you know of any more that aren’t listed here, please let me know and I can update the list!!

It should also be noted that "potions" can also be used for other purposes. This includes creating special effects for movies (mentioned in Vil's Labwear vignettes) and enhancing the effects of skincare (book 6, Azul Ceremonial Robes, etc.).

You'll notice that the effects of these potions can also be achieved via regular spellcasting. (In fact, we see Adeuce practicing color changing magic in Floyd's Labwear vignettes + Vil using color changing magic to help himself hide from paparazzi, etc., Jack's/Malleus's/Azul's UMs also allow them to do things without the help of potions.) Because of this, I believe that potions are meant to be an alternative way of spellcasting without actually needing to use magic. This makes already prepared potions usable by mages who don't want to expend energy/build blot as well as by NON-MAGES.

Within the world of TWST, there is an occupation known as the “medical mage”, who appear to combine magic and medicine into their practice. Furthermore, what is called “Potionology” in EN is written as 魔法薬学 (literally, "magic pharmaceuticals") in JP, implying that there is, in fact, an intersection between magic and medicine. This is similar to how "technomancy" is described to be the cross between magic and technology.

In terms of a "healing potion", there are instances which show that a magic potion may heal or at least speed up the body's natural healing process. For example, in 7-68 of the main story, Baur gives Lilia something to drink to help him with the dire blow he just took. It doesn't appear to restore him to full health though, as Lilia states he still needs rest afterward. In EN, they use the term "potion" but in JP they use "薬" (kusuri), which is "medicine". Baur qualifies the character with "魔法" (maho), which is "magic", so the term he's using is "magic medicine". This is probably the closest thing to a "healing" potion that we know of in the TWST lore.

So technically, yes, TWST has "healing potions". I wouldn’t say there is one blanket cure-all potion though; based on what we know of potionology and how it’s very similar to irl chemistry classes, we can assume that there are generalized “healing potions” but that there must also be far more specialized and targeted ones, similar to medicine irl or non-enchanted or non-magic infused medicine. This is supported by Riddle mentioning a potion that instantaneously heals burns, implying that there is no “cure-all”.

I would imagine that, like transformation potions, “healing potions” would have to be highly regulated since they’re basically a drug 💀 (There would probably be OTC types too, given proper governmental approval!)

[fuck-customers]

Being a secretary is maddening. I spend all day hounding clients to send me their documents. The bulk of the actual work I do takes so much less time than getting nepo baby businessmen to do the bare minimum. All day I’m spam calling guys who make more money in one month than I’ll ever have in my bank account—telling them they need to spend 5 minutes at a computer to make it possible for their time sensitive task to get done. Just send me the files. Send me the files that your secretary prepared for me in a folder labeled “Send to anon at email dot com” -literally everything gets spoonfed to them and it still takes weeks- and the spot shit gets stuck on is always the execs wanting to “check” their employee’s work before sending it out… except they can’t even be assed to read the damn documents that are, I cannot stress this enough, critical for the continuation of their company that theyre so proud of. So it sits on their desk for two weeks while I bother their whole office, until they finally just send it, unread, with “DRAFT - DELETE BEFORE SENDING” in the header and a blank signature line on the bottom. Thankfully the job benefits include mental health coverage, because there is an intense concoction of prescription pharmaceuticals behind my customer service persona that makes it impenetrable. Otherwise i would genuinely flip my cubicle.

Posted by admin Rodney

[ckret2]

Roughly what would you say is the rarity of "psychics"/shapes with the same mutation as Bill in your story? Something like a percentage or a "one in X number" sort of thing

Extremely rare.

If I give a specific number people are gonna like, start comparing it to the prevalence of real world conditions, figure out how much of the population has it, figure out how well-known it should be in the general population based on that number, etc. That's annoying. This is not the kind of worldbuilding where we're going "okay, here's what percentage of the population has this thing, from that percentage we can figure out how this thing is viewed socially." This is worldbuilding where we already know how it's viewed socially, and trying to work backwards from that to invent a percentage just runs the risk of accidentally creating a number that doesn't make sense with how it's viewed. There's no good reason to try to make a number.

It's so rare that there are some people who haven't heard of it, but common enough that plenty of people HAVE heard of it and you can readily find research papers studying it—but, not a lot of research papers.

It's so rare there are more people who'd like to study it than there are psychics volunteering to be studied.

It's so rare that it's more likely to be the subject of military research than medical research, because the military could sure make use of a psychic, but the pharmaceutical industry is like "we don't think there's enough potential patients for us to make back the money we'd spend developing psychic-specific treatments."

It's common enough to be scientifically verified but rare enough that it's extremely easy to make up mystical bullshit about the condition with low risk of running into anyone who can prove you wrong.

It's well-known enough that there are movies about psychics but it's not so common that an actual psychic has ever played the lead role in one.

They're rare enough that if anyone argued "why aren't psychic actors playing psychic characters?" someone else could argue back "name ONE psychic actor" and they wouldn't be able to come up with a name.

It's common enough that Bill briefly met a few other psychics before Euclydia's destruction, but did not know any on a day-to-day basis.

There's enough medical knowledge available about it that a doctor can specialize in treating issues related to being psychic, although they can't make a living only treating psychics; and it's rare enough that there was only one specialist with experience with psychics within travel distance of Bill's family.

Bill only ever ran into one other psychic in this doctor's office, and that's the first one he ever met. He had to go to the Doctor's Office For Psychics to find his first fellow psychic, and he didn't even manage to find two that way.

The one thing people are most likely to know about psychics is that they can see through objects and see what's on the backs of cards and hidden inside boxes and stuff like that, but they're rare enough that casinos don't have rules against psychics playing card games because it doesn't dawn on people that that's, like, an issue they need to prepare for.

Psychics are so rare, and the theory that light radiates from some source in a higher dimension is so new, that Bill was the first person in history to put two and two together and realize that the tiny white points in his peripheral vision are the hypothetical "stars" he read about in pop sci articles.

And here's everything we know about their population size from canon: they're rare enough that Bill calls it a "rare mutation," but common enough that somebody recognized what Bill has and was able to tell him it's a rare mutation (rather than, say, leaving him to assume he's the only person like this in history).

So they're whatever percentage of the population makes sense for that. And remember to consider that psychics having such remarkable skills would increase how widely they're discussed compared to less glamorous conditions with similar percentages, which makes them look more common than they are; and that some psychics might not know they're psychic or hide the fact that they're psychic to avoid negative attention, which makes them look less common than they are; and that the bigger the population is, the smaller their percentage of the population can be while still having a large enough population to reach the tipping point where they can be verified as really real and general knowledge of them spills into public consciousness; and that we don't know how long ago they reached that tipping point.

I ain't about to figure that number out.

[asence]

Asence Inc. provides premium-quality effervescent tablets and formulations, ensuring global distribution and superior pharmaceutical standards.

[sleepynoons]

WONDER BY ADOY – aizen sosuke (bleach) x afab!f!reader, modern!au + arranged marriage!au, sfw

genre – angst word count – ~2,000 warnings – n/a synopsis – aizen sosuke's the heir to the largest pharmaceutical company in japan, and you're his arranged wife. but your wedding oaths mean nothing when he doesn't love you and won't even look your way. unfortunately, you can't contain these feelings of yours for much longer.

When Sosuke comes home, dinner's already prepared for him, resting on a tray at his usual seat at the dining table. All of the food is still warm, recently made in fact, and he sits to eat his dinner before he needs to go see you. As he’s eating, you’re showering, the warm water comforting against the winter cold that seeps through the walls of the house and clings to your skin. Since the beginning of your marriage, the two of you have never eaten together, aside from business events and meetings with each other’s parents.

By the time you’re in bed, dry and relaxing against the headboard with a book in your hands, Sosuke knocks on your door.

You tell him to come in.

“Sorry for interrupting. I wanted to let you know that I will return at 8 to pick you up for tomorrow’s gala.”

He shuts the door behind him, leaving you to leaf through your novel before you go to sleep, repeating his words in your head, letting his voice wash over you, until you're no longer conscious.

In the morning, you wake before him so that you can prepare him breakfast and coffee, as well as his bento for lunch. You never worry about waking Sosuke because he sleeps on the second floor, whereas you live on the first, and he is at the far end of the hallway where the noise you make in the kitchen can barely reach him. It doesn’t really matter, though, because he’s already awake, washing his face and replying to emails that have accumulated overnight. And like dinner, you retreat to your room, and Sosuke comes down to eat. You try to pick up where you left off in your book, but really, you’re straining your ear the entire time, waiting for the click of the lock as Sosuke shuts the front door behind him as he leaves for work.  

The rest of the day is also spent alone. You clean, grocery shop, and tend to the garden. Sosuke sits in meeting after meeting after meeting. But this daily monotony is cut short by the gala occurring at night.

You had received a few packages in the mail within the last week that you can finally unwrap. You drag the boxes out of your closet, and with a razor, rip through the tape with clean swipes to reveal ribboned boxes with printed anagrams and brand names. Sosuke had specifically asked you to wear this outfit, and you’re excited to see what he has chosen for you this time.

On the drive home, Sosuke is on a call with his secretary, going over the gala’s attendance list, highlighting connections he will be introduced to, existing partners and collaborators he cannot forget to greet, competitors that will try to get under his skin. When he arrives, you’re outside, and as you make yourself comfortable in your seat, he offers his compliments.

“Cream suits you.”

You reply that it's all thanks to his excellent taste.

He resumes his conversation, and you turn your cheek to look out the window. And like dinner, like breakfast, you retreat into your own mind, and Sosuke continues to work.

An hour later, the two of you arrive at the venue, a massive hotel tucked away in a mountainside. As instructed by the organizers, Sosuke pulls up to the gated entryway, where staff members come to open your doors and take the car key away to park on your behalf. 

You step out, heels gently scraping the gravel and pavement, but you do not stand until Sosuke makes his way over to your door. He holds out his hand, which you take, and once you’re up, he wraps an arm around your waist and pulls you slightly into his side, smiling gently as he brushes the side of your cheek with his other hand. You reflect his expression, tilting your face into his touch.

“It will be a slight walk uphill, my love.”

Shaking your head, you mumble that you can manage.

As soon as the two of you step into the lobby, in its marble-floored, chandelier lit, dark oak-accented grandeur, Sosuke is approached by several businessmen, most older and executives of their own respective companies.

“Sosuke-kun – ah, wait, not anymore! Aizen-san, how are you? And is this your wife?”

If you recall, this person seems to be the treasurer of a large chain pharmacy in Singapore.

You bow, and Sosuke shakes hands with the treasurer.

“Please, call me Sosuke, my father is still the acting president, sir. And yes, I am glad to finally acquaint you with my wife.”

These pleasantries continue throughout the rest of the night – with the COO of a lab equipment manufacturing company, three local hospital directors, a representative of another chain pharmacy, and the founders of a biotech startup from the United States. You are led by gentle tugs from one conversation to the next, introducing yourself when you're prompted, occasionally fetching a bite of food or a flute of champagne, always returning to Sosuke’s side by a loop of your arm through his.

“Sosuke is a great husband, isn’t he?”

Currently, you're at a corner in the large conference room where there are drinks and other refreshments. An older lady, in her mid-50s or so, stands next to you, as you grab a glass of water, taking care not to crease Sosuke’s blazer which you hold in your other arm. She's the wife of the dean of an elite nursing school, and you recognize her as a long-time friend of the Aizen family. Diligently, you offer the glass to her, which she takes with a slight dip of her head, and with a gesture of your hand, you compliment her knitted shawl.

“My granddaughter.”

Though you would prefer to return to Sosuke, leaving such a conversation so abruptly would indubitably damage his reputation. Instead, you inquire the lady about her granddaughter’s age, favorite hobbies, and health. She responds enthusiastically – barely five years old, enjoys knitting and origami, very healthy – before shifting the conversation back to your relationship.

“Sosuke’s always been a caring boy. He must love you.”

You chuckle behind your hand.

“I love him very much.”

By the gala’s conclusion, a fog has descended over the mountainside, ghosting down its slopes and forested ridges, as well as much of the highway leading out and towards the city.

Sosuke’s satisfied. He was able to meet the people he wanted to see, assess the relationships he’d been investigating, and schedule a few tours of factories he’d been planning to visit. Once he goes home, he can move onto next steps. He will have to shift a few meetings around for tomorrow, but they were low priority anyway. He also has to review the documents for that recent inspection that was conducted, though he highly doubts anything of concern came up. Another late night.

As usual, car rides home are quiet. There are no more calls for Sosuke to take, and when he glances at you, you’re staring out the window, hands folded over his blazer that you’ve draped over your lap, chest slowly rising and dropping with deep breaths, stuck in your own daydreams.

In reality, you’re reminiscing over your bold proclamation to the older lady. How daring, almost presumptuous of you, to so arrogantly lay claim to your feelings for Sosuke. But you’re relieved that the elder was understanding and sympathetic of your bursting emotions, and she had prayed for your relationship to last long and well.

For as long as you can remember, Sosuke has been your whole life. You partook in etiquette classes, biology and chemistry tutoring, dance lessons, flower arrangement competitions, fusui lectures ever since you were young, as was expected of the daughter of the head of the Biotechnology and Pharmaceutical Examination Division of the national Japan Patent Office. Your father managed all vaccine patents, so it was no surprise that your hand in marriage was crucial for many opportunists.

At the time, you didn’t know that your life would be dedicated to Sosuke and your role as his wife, but you dutifully listened to your father, only hoping that all of your effort would pay off. After all, hundreds of thousands of women have done it before you. No matter who your husband will be, you promised your father that you would become a wife no man would have to worry about.

In seventh grade, you were introduced to Sosuke at your omiai, though there really wasn’t much to consider. His father is the president of one of the largest pharmaceutical companies in the country, and was often crossing paths with yours. There was no doubt that the two of you would get married, given the strategic business advantages and both of your inabilities to deny your parents.

Therefore, your marriage to Sosuke was speedily arranged.

Many of your girl friends growing up, all of similar class and privilege, all held a certain level of contempt or resentment. And you did, too, for a long time. But ever since you laid eyes on Sosuke – his tousled brown hair, pleasant smile, gentle eyes, sturdy frame –, you were convinced you had been blessed by the deities, presented with the best husband of a stranger anyone could ask for.

And his dignified and measured confidence has only furthered your affections for him. He only asks, never demands, when he needs something from you. He always finishes the meals, coffee, tea you prepare for him to the last bit. He brings you to business functions, like tonight’s gala, even though you know he’s busy and doesn’t need to.

You shake your head, releasing a soft sigh. It must be that one extra sip of alcohol you had, because your audacity seems to have no end. In your mind, you apologize to the older lady for what you’re about to do, for wasting her genuine blessings and wishes.

You’re almost home, car changing into the left lane and crossing onto the small bridge that leads into the residential area where the two of you live. The fog has made its way here, too, settling as a layer atop the water and mugging the streetlights lining the sidewalk. The weather forecast mentioned something about it snowing over the weekend.

“Stop the car.”

With a quick check in the rearview mirror, Sosuke pulls to the side.

“Is something wrong?”

You unbuckle your seatbelt and grab the door handle to let yourself out.

Sosuke glances at the clock on the dashboard.

You step out, swaying slightly in your heels before regaining balance, and walk over to the rail of the bridge. The water's dark, and you wonder if anything can survive in the icy, rapid currents underneath.

Deep down, you know Sosuke only calls you his wife in front of others. The two of you haven’t embraced each other either, not even the night of your marriage. His secretary doesn’t come to distract you with lavish gifts or day trips. Sosuke doesn’t even look your way unless absolutely necessary.

Turning around, you walk back. You catch him checking the time again before he looks up at you.

You exhale, watching the snowy puff of your breath separate and dissipate.

“Sosuke, you’re very kind.”

“Are you cold?”

“I met your family friend, and she asked if you loved me.”

“I see. We should head home.”

“I love you.”

Silence.

“You go first. I will be back soon.”

You shut the door, and for a second, through the tinted windows, you can make out the harsh look in his eyes. He stares at you for a few brief moments before he pulls away, and you watch until the crunch of the road underneath the tires and the beam of the tail lights are no longer so distinct, so stark, in contrast to the still haze, the dark waters below, the steeled grip you have on his blazer.

winter event masterlist

[ellaa-writes]

The Beast Within

author note: Part 1. Part 2 here. I wrote something close to this story on my first blog but I decided to redo it and maybe make it into a series? Anyways Alpha König is back! Alpha König headcanon can be found here. Will help with understanding this König. masterlist

summary: Omegas are rare, in a world full of Alphas and Betas. Being a Omega was not only dangerous but they were highly sought after. After living your life has a Beta in disguise, you meet a scary Alpha, but not any normal alpha. But a gaint Apex Alpha who won't stop at anything to make you his.

tags: 18+ only, slightly dub-con/non-con. Kidnapping vibes, Alpha/Omega dynamics. Female reader Mentions of alcohol and blood. Marking/biting. This is an Alternative Universe (which will be expanded). No smut in this but their will be eventual smut. vague mentions of nudity. Not proof read.

This was dangerous but it was exhilarating. The adrenaline coursing through your body gave you the sweetest high. You were in a packed night club somewhere in central Europe. The special blend of herbs and modern day pharmaceuticals that your best friend Kalina gave to you earlier, helping to mask your true identity. You were an Omega, which is very rare in this day and age. And there had to be at least hundreds of Alphas packed into this dimly lit club, bodies grinding on bodies. The musky smell and loud music filling the air.

Your friends got a private table on the 2nd floor, above the dance floor you were currently looking down on. You should be at home, preparing for you next heat that is only a couple of days away. But you've had a rough week at work, wanting nothing more but to feel the buzzing numbness from the alcohol. Turning back to your friends, one of them sliding a shot glass in your direction. Grabbing it and holding it in that air with the others. Bringing it to your lips and savouring the burning liquid. Joining the rest in slamming the small glass back in the table. One of your friends already trying to flag the bottle girl down for another round of shots. You sink was feeling warm and sticky, the alcohol doing its job. You closed you eyes for a second, enjoying the music and the vibration it sent through your body. But there was something else, something different.

It began creeping up your slow spine, goosebumps forming in its path up to the back of your neck. Where it bit down and stung, your reflexes acting out you touched your neck. Trying to find any indication you were bitten, but there was nothing. That strange feeling was sitting heavy in your stomach, it was either the 3 shots and 2 margheritas you had or the world was about to end. You slowly turned back towards the dance floor, but it wasn't down below. It was sitting across, in another private section. His eyes were burning flames of ember staring into you with such a fierceness that it scared you a bit. Your best friend reached out touching your arm which snapped you out of the trance you were in. Bringing you back to your surroundings. She looked at you with concern "You feeling ok?" she began rubbing her hand up and down your arm. You gave her a smile, nodding you head "Yeah, yes... I'm good. Just getting a little warm that's all." you let her know. A few of your friends began cheering when the server brought over another tray of shots. Making you and her to laugh, joining in and grabbing the glass from the tray before it was lifted away." Hold on, wait up. I just wanted to say, that I love you all so much and let's all hopefully get laid tonight. Alright, good!" Meave said, she was the oldest out of your group. Her gorgeous red hair danced around her shoulders while she did her speech, looking right into your eyes when she mention getting laid. Which made you blush, feeling a little embarrassed that she even said that. But it wouldn't be true to Meave. Her and Kalina are cousins, after meeting Kalina in year 1 you three became inseparable. "Oh don't listen to her babe." another one of your other friends whispered into your ear, making you giggle. You took the shot, setting the glass back down. You all but almost forgot about the stranger staring you down. But another stinging bite at the base of your neck, making you jump and yulp out of shock. Kalina and Maeve looking at you with concern. "I think something bit me" you yelled out, making a few of them laugh. You didn't notice it, when Kalina found the same eyes you saw earlier. The same uneasy feeling washed over her, she knew what he was. She could feel the power radiating off of the Alpha, but he wasn't just any ordinary Alpha. He was an Apex Alpha, she knew you were in danger. Apex Alphas were stronger than a normal Alpha, not just in psychical strength but mentally too. Their senses highented, making them damn nearly a God. At one point in history they were viewed as the closest thing to a demi-God, many believing they were the most special, having the blood and DNA of the gods running through them.

She grabbed you arm quickly standing up and pulling you up with her. Laughing you asked her "What's going on" trying to balance in the heals that Meave borrowed to you. "We need to go, like right now." she began pulling you towards the stairs, ignoring the calls from the others. She lead you down the steps, through the bodies and to the entrance of the club. "Hold up, Kalina. What the hell is going on." you tried pulling back, to slow her down but her grub only got stronger while she dragging through the exit and out onto the street. "Hey Kalina, talk to me." you tried getting in front of her. Trying to get her attention, but Kalina was in flight mode. Searching the street for any sign of taxi, when she found one she marched right over with you still in tow. Banging in the front passenger window, catching the driver off guard. "Are you running?" she asked quickly, the driver bossing his head and unlocking the door. "Hurry, get in. Quickly." she said while opening the back seat door and shoving you in. "Kalina what the fuck is going on." you asked while she closed the door. Reaching for the window down button. "Please get home and lock up immediately. I'll tell you later." she told you. She then went back to the front window and gave the driver your address before he quickly pulled away from the street and towards the direction of your small apartment.

You sat in the back seat, confused and starting to feel sick. The alcohol turning into bricks in your stomach.

Kalina watched has the taxi drove away, praying you'd get home safe and listen to her and lock up. Hoping that the Alpha would lose your sent. She turned back towards the club, noticing the Alpha storming out. His nose high in the air, sniffing you out. His eyes snapped towards her, her own fear taking over. She should have gotten in the car with you, but now she's in the path between a angry honey alpha and sweet omega pussy. She always pittied you, when you were young and coming into puberty. She could smell the changes happening to you, they were different than hers. She was a simple beta, but you became an omega. She knew the rarity of it, she also knew the risk of began one. Many of the omega being snatched up, nothing more than breeding machines to produce more alphas, female or male. She began helping you mask your smell at a young age and disguising yourself as a beta.

Sticking her head up high and ignoring the heated look he was giving her. She began to make her way back inside, but not before being pulled to the side by a pair of very thick solid fingers. The alpha had her corned, looking down at her. His nostrils flaring with anger, his chest rising and falling. He was trying to control himself, trying to push the animal that was inside him down. "Where is she." he said in between breaths. Kalina yanked her arm back "None of your business, now will you please excuse me." she began to move past the alpha but he grabbed her again. "Get off me." she yelled. Causing the bouncer and a few others to look in their direction. "You can't hide her forever." he called out to Kalina as she disappeared back inside. She hoped he was wrong.

You made your way inside you one bedroom apartment. Closing the door and locking in behind you. Your feet were sore and your head felt heavy. Walking into your kitchen to grab and glass of water. Standing in the dark, debating if you should wash your face or deal with the consequences in the morning. Refilling the glass you slowly walked to your small bathroom, turning the light on which made you wince. Pulling your hair back and using your expensive cleanser, one of the few things you splurge on. You found yourself kicking off the heals and peeling the tight dress you hand on off and falling into your bed. Only wearing the silky panties you had on, pulling the blankets down and over your body. Sleep found you quickly, drifting off into dreamland.

You woke a few hours later to what sounded like banging. You sat up in your bed, the blanket having fallen to your hips. Your tits out in the open, the air was cold causing your nipples to perk up. Listening in the dark for anymore noises and not hearing anything else you laid back down. Snuggling into your pillow, ready to fall back to sleep. But you heard your bedroom door slowly creak open. Your eyes snapped open, every hair on your body standing straight up. The same stinging from earlier made its way to the base of your neck again.

You instinctively reached out to your phone, but before you could full grab it. It was thrown across the room and you were flipped over on your back. The blanket that was covering your chest now on the floor. Thick hard fingers found themselves around your throat. The same burning ember eyes from the club were looking down at you. You didn't get a good look at him before, but you could see him clearly now. He was massive, not only in size but also in height. His head had to be nearly touching the ceiling. He was looking at with with such intense lust, the corners of his mouth turning up into a smirk. "I found you." was all he said before he removed his hand from your throat and brought his mouth to replace it. You could feel his hot breath fanning out over you jaw and down your chest. He pushed his nose into the vein that ran down the side, lightly licking its trail down to your crease were you neck net your shoulders. He paused a bit before he opened his jaw and bit down hard. Causing you to screaming and thrash, trying to push this gaint off of you. The trance you were in breaking and the panic and fear consuming you. Your screams got louder before his hand found its place over your mouth. "Shhh, darling. It's ok, I found you. Your safe now." he whispered into the side of your temple. Having released your neck, you could feel the blood drip down your back and onto the sheets below you. You began feeling dizzy, your vision getting blurry. He was still cooing into your temple, lightly kissing it and brushing his free hand over your hair. Trying to easy your fear and pain. You were stronger than he thought, fighting his trance once again. Once he felt you go limp in his arms, he let you go. Moving towards your closet, pulling out a shirt to cover you up with. He needed to cover you up, he knew if he didn't he would lose control. The beast in him still snarling and growling to get out.