#papillarythyroidcancer

[cytgen]

Abstract Long noncoding RNAs (lncRNAs) have recently been identified as crucial biomarkers of papillary thyroid cancer (PTC). In this study, we aimed to investigate the biological function and potential clinical role of lncRNA ENST00000494165 in PTC. From January 2019 to December 2019, 226 PTC patients who underwent preoperative thyroid US-fine needle aspiration biopsy(US-FNAB) and confirmed by postoperative pathology were enrolled at our hospital. Thyroid tissues were collected from FNAB samples and stored in the refrigerator at –80°C. qRT-PCR (quantitative reverse transcriptase-polymerase chain reaction) analysis was performed to detect the relative expression level of ENST00000494165. CCK-8 (Cell Counting Kit-8) and colony formation assay were performed to detect the cell proliferation ability. Cell migration and invasion abilities were evaluated by transwell and scratch assay. We also evaluated the relation between the expression level of ENST00000494165 and the clinicopathological features of PTC. Functional assays demonstrated that the cell proliferation, migration and invasion abilities were all promoted in PTC cell lines when ENST00000494165 expression was overexpressed. The expression of ENST00000494165 in the lymph node metastasis group was significantly higher than that in non-lymph node metastasis group. High level expression of ENST00000494165 was significantly associated with lymph node metastasis of PTC (P < 0.001). The overexpression of ENST00000494165 promoted the progression, migration and invasion abilities of PTC and was significantly correlated with lymph node metastasis in PTC. ENST00000494165 could act as a possible promoter gene and a potential biomarker for PTC.

[sircaterpillar1267]

My Cancer Story #1

When I was 12 (2017) late one night I noticed a lump on my neck that wasn’t there before. My first sleepy thought was that it was an adam’s apple... so I googled to see if girls had one, and if it was meant to be on the side of the neck. Eventually I deemed my neck lump completely fine and healthy then forgot about it until this year (2020). One afternoon I was laughing hard at something my mum said and she noticed the huge lump on my neck for the first time since you can’t really see it unless I tilt my head back like I did just then. We went to the doctors to get it checked out. Eventually that lead to getting an ultrasound, then an ultrasound guided fine needle biopsy. 

That biopsy happened on Wednesday last week, and we weren’t expecting the results until Monday (Tomorrow) but we got them sooner than expected.

On Friday after school, I get home and my mum told me to sit down on the couch. “I have something to tell you. The doctors called about your results.” She told me. She then proceeded to tell me that I have Papillary Thyroid Carcinoma or more commonly known as Papillary Thyroid Cancer.

The doctors are already organising to get my whole thyroid surgically removed and we should find out a surgery date by the end of the week.

I have unknowingly had cancer for three years... which means it is likely that it has spread to my lymph nodes now.

The most surprising part about this to me is the fact that this is a cancer that is most common in 30-50 year olds, not 12-15 year olds.

Honestly I wasn’t even surprised when my mum told me I have cancer, I guessed it about a month ago. I just don’t care anymore, but at least this cancer has a very high survival rate from my research.

Also I have named the lump on my neck! Her name is Gertrude.

^^ Gertrude, I gave her a face. She is as big as the circle for her head, so about the size of a golfball. She is a toxic bitch and is no longer welcome in my body. 

I know you can’t really see the lump, but it is there and it hurts.

[designbybrianne-blog]

Happy #Friday everyone! Time for #fridayintroductions ❤️ This week I thought I'd share some fun facts about me! 1. I've worked at @starbucks for 4+ years (off and on again). I did the Coffee Masters program and I am a certified #coffeemaster ...I also have my own black apron for work 😍 2. 99.9999% of my wardrobe consists of black, grey, or white clothing. I rarely wear colors. 3. I recently had a heart procedure done to correct issues I've had with my heart for the past 10 years. Last year I was diagnosed with #papillarythyroidcancer and am now cancer free! 4. I've never seen The Matrix movies, Back to the Future, or the Terminator movies. (But I am currently watching The Matrix since I'm in bed rest!) 5. One of my favorite stories of all time is Alice in Wonderland. I also did a photo series based on the book! Tell me about you! Leave a comment below of some of your favorite things! 😊❤️ (at Houston, Texas)

[sparklemepink8]

This cute little vial holds the nuclear medicine I am ingesting today ... doesn't that just sound weird ? LOL #I-131 #cancer #cancertreatment #cancertherapy #readyforthistobeover #overit #thyroidcancer #thyroidproblems #thyroidectomy #papillarythyroidcancer #modernmedicine #nuclearmedicine #wherearemysuperpowers #littlebluepill #headache

[sircaterpillar1267]

My Cancer Story #2

So it’s been a week...

I don’t really believe I have cancer yet, but I’ve read the papers from my doctor’s office and it says it right there. We also still don’t have a surgery date, they said to wait another week. Also I’m not going to be seeing a paediatrician since they have no experience in thyroid surgery, so I get to go to the big boy hospital with all the big scary adults.

Honestly I’m starting to get a little scared and stressed, I mean before I found out about the cancer my dog got cancer, my dad got arrested, and my grandma past away, so it’s been a crazy past few months. Also the doctors are worried about my cancer because my tumour is way bigger than 1 cm and when it’s bigger than that the risk of it spreading is 75%. So that information added with the fact that I’ve had it for three years they don’t know how far it’s spread or how bad it is and they won’t be able to find out until the surgery. 

Another thing, my family doesn’t exactly have a lot of money, especially with my dad in jail (who earnt the most out of everyone) and my mum still having to look after my younger brother.

On a lighter note; my older sister and mum have both accidentally let it slip that my grandad is coming up from Tasmania to come support me. He and I used to be really close when I was younger, and before his wife (my nana) passed from pancreatic cancer. as you can see cancer runs in the family. But I am very excited to see him again, it’s been so long.

I’ve also been having the urge to do something kinda crazy but not too crazy ya know? like cut my hair short or something (I have pretty long hair). I don’t know about that though since I really like my long hair. I’ll take any suggestions though if anyone sees this and/or reads all the way through this. 

So yeah, see you in the next update on my tumour, Gertrude, I guess.

[arrangoiz]

👉 Thyroid nodules are common and consultation with your doctor and a dedicated neck ultrasound to evaluate the thyroid gland, lymph nodes and adjacent neck structures is a good tool for early detection. 👉Thyroid nodules can be big or small, palpable or non palpable, visible or non visible. 👉Thank you all for creating awareness #Arrangoiz #ThyroidSurgeon #ThyroidExpert #ThyroidCancer #ThyroidNodules #PapillaryThyroidCancer #EndocrineSurgery #CancerSurgeon #HeadandNeckSurgeon #CASO #CenterforAdvancedSurgicalOncology #PalmettoGeneralHospital #SurgicalOncology (at Miami, Florida) https://www.instagram.com/p/CFi-oj9nCIU/?igshid=lido65ebyy0j

[arrangoiz]

Sociedad Quirúrgica S.C tiene un experto en el manejo del cáncer de tiroides:

Rodrigo Arrangoiz MS, MD, FACS


Entrenamiento:
• General surgery:
• Michigan State University:
• 2004 al 2010

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:
• Fox Chase Cancer Center (Filadelfia):
• 2010 al 2012

• Masters in Science (Clinical research for health professionals):
• Drexel University (Filadelfia):
• 2010 al 2012

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:
• IFHNOS / Memorial Sloan Kettering Cancer Center:
• 2014 al 2016

#Arrangoiz
#Teacher
#Surgeon
#Cirujano
#ThyroidExpert
#ThyroidSurgeon
#CirujanodeTiroides
#ExpertoenTiroides
#ExpertoenParatiroides
#Paratiroides
#Hiperparatiroidismo
#CancerdeTiroides
#ThyroidCancer
#PapillaryThyroidCancer
#SurgicalOncologist
#CirujanoOncologo
#CancerSurgeon
#CirujanodeCancer
#HeadandNeckSurgeon
#CirugiaEndocrina
#CirujanodeTumoresdeCabezayCuello
#OralCavityCancer
#Melanoma
 
Visite su pagina:
http://www.cirugiatiroides.com
 (at Sociedad Quirúrgica S.C.) https://www.instagram.com/p/B1HOEnOH7dw/?igshid=ao0yzr3y5f2v

[arrangoiz]

https://news.yahoo.com/4-signs-thyroid-cancer-watch-180900550.html. #Arrangoiz #Teacher #Surgeon #Cirujano #ThyroidExpert #ThyroidSurgeon #CirujanodeTiroides #ExpertoenTiroides #ExpertoenParatiroides #Paratiroides #Hiperparatiroidismo #CancerdeTiroides #ThyroidCancer #PapillaryThyroidCancer #SurgicalOncologist #CirujanoOncologo #CancerSurgeon #CirujanodeCancer #HeadandNeckSurgeon #CirugiaEndocrina #CirujanodeTumoresdeCabezayCuello #OralCavityCancer #Melanoma https://news.yahoo.com/4-signs-thyroid-cancer-watch-180900550.html https://www.instagram.com/p/B0s7hyqHt9O/?igshid=sxk2gdwxof8n

[arrangoiz]

https://news.yahoo.com/4-signs-thyroid-cancer-watch-180900550.html. #Arrangoiz #Teacher #Surgeon #Cirujano #ThyroidExpert #ThyroidSurgeon #CirujanodeTiroides #ExpertoenTiroides #ExpertoenParatiroides #Paratiroides #Hiperparatiroidismo #CancerdeTiroides #ThyroidCancer #PapillaryThyroidCancer #SurgicalOncologist #CirujanoOncologo #CancerSurgeon #CirujanodeCancer #HeadandNeckSurgeon #CirugiaEndocrina #CirujanodeTumoresdeCabezayCuello #OralCavityCancer #Melanoma https://news.yahoo.com/4-signs-thyroid-cancer-watch-180900550.html https://www.instagram.com/p/B0s7hyqHt9O/?igshid=tts529zbw8aw

[arrangoiz]

Rodrigo Arrangoiz MS, MD, FACS es especialista en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica compleja:Fue egresado como Médico General de la Universidad Anahuac:Graduado Suma Cum Laude. Es miembro de Sociedad Quirúrgica S.C.:Que es el único grupo quirúrgico en México en donde todos los socios se entrenaron en las mejores instituciones académicas de los Estados Unidos de América. El Doctor Arrangoiz es experto en el manejo del: Cáncer de Tiroides:Cáncer papilar de tiroides

Cáncer folicular de tiroides

Cáncer medular de tiroides

Cáncer anaplásico de tiroides

Patología Quirúrgica de Tiroides:Bocio multi nodular no toxico sintomático  Bocio multi nodular toxicoHipertiroidismo

Hiperparatiroidismo:Hiperparatiroidismo primarioHiperparatiroidismo secundarioHiperparatiroidismo terciario

Tumores de Cabeza y Cuello:Cancer de la cavidad oral

Cáncer de faringe:

Nasofaringe

Orofaringe

Hipofaringe

Cáncer Laringeo:

Cáncer supraglótico

Cáncer glótico

Cancer subglótico

Cáncer de glándulas salivales:

Glándula Parótida

Glándula submandibular

Glándula sublingual

Glándulas salivales menores

Cáncer de piel de la cabeza y cuello:

Melanoma

Carcinoma basocelular

Carcinoma epidermoide

Carcinoma de Merkel

Dermatofibrosacroma Protuberans

Cáncer de Mama. 

Cáncer de piel:

Melanoma

Carcinoma basocelular

Carcinoma epidermoide

Carcinoma de Merkel

Dermatofibrosacroma Protuberans

Fue entrenado en las mejores instituciones académicas de los Estados Unidos.

Mantiene certificaciones por los Consejos de Cirugía General y Cirugía Oncológica en México y en los Estados Unidos de América.   

Su entrenamiento incluyó:Cirugía General y Gastrointestinal:Michigan State University (2004 – 2010)

  Cirugía Oncológica / Tumores de Cabeza y Cuello / Cirugía Endocrina:Fox Chase Cancer Center en Filadelfia (2010 al 2012)

  Maestría en Ciencias (Clinical Research for Health Professionals):Drexel University (Filadelfia) (2010 – 2012)

  Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina (2014 al 2016):IFHNOS / Memorial Sloan Kettering Cancer Center

Ha participado en múltiples cursos y congresos como Conferencista y Profesor Invitado, así mismo ha realizado diversas publicaciones y artículos sobre temas relacionados con su especialidad.

Es pionero en México de la:

Cirugía minimamente invasive radioguida de paratiroides.

Se encuentra certificado por el Consejo Mexicano de Cirugía General y el Consejo Mexicano de Oncología así como es de los pocos mexicanos certificado por, el AMERICAN BOARD OF SURGERY,  el cuál le faculta como cirujano con licencia en los EU.

Es miembro de diversas asociaciones médicas como el:American College of Surgeons, American Thyroid Association, American Society of Endocrine Surgeons, American Medical Association, American Society of Clinical Oncology, Association of Academic Surgeons, Society of Surgical Oncology,  The Society of Surgery of the Alimentary Tract, Society of American Gastrointestinal Endoscopic Surgeons, y la American Society of Breast Surgeons, entre otras.

Gracias a esto el Dr. Rodrigo Arrangoiz es reconocido como uno de los mejores especialistas en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica en México, además de ser galardonado como uno de los 50 mejores médicos de México en los Top Doctors Awards 2018.

#Arrangoiz

#Teacher

#Surgeon

#Cirujano

#ThyroidExpert

#ThyroidSurgeon

#CirujanodeTiroides

#ExpertoenTiroides

#ExpertoenParatiroides

#Paratiroides

#Hiperparatiroidismo

#CancerdeTiroides

#ThyroidCancer

#PapillaryThyroidCancer

#SurgicalOncologist

#CirujanoOncologo

#CancerSurgeon

#CirujanodeCancer

#HeadandNeckSurgeon

#CirugiaEndocrina

#CirujanodeTumoresdeCabezayCuello

#OralCavityCancer

#Melanoma

Visite sus paginas:

http://www.cirugiatiroides.com

http://www.hiperparatiroidismo.info

https://www.topdoctors.mx/doctor/rodrigo-arrangoiz-m-s-m-d-f-a-c-s

https://www.linkedin.com/in/rodrigo-arrangoiz-ms-md-facs-7624b779/?originalSubdomain=mx

  Cirujano de Cabeza y Cuello de Sociedad Quirúrgica SC Rodrigo Arrangoiz MS, MD, FACS es especialista en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica compleja:Fue egresado como Médico General de la Universidad Anahuac:Graduado…

[arrangoiz]

Rodrigo Arrangoiz MS, MD, FACS es especialista en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica compleja:

Fue egresado como Médico General de la Universidad Anahuac:

Graduado Suma Cum Laude.

Es miembro de Sociedad Quirúrgica S.C.:

Que es el único grupo quirúrgico en México en donde todos los socios se entrenaron en las mejores instituciones académicas de los Estados Unidos de América. 

El Doctor Arrangoiz es experto en el manejo del:

Cáncer de Tiroides:

Cáncer papilar de tiroides

Cáncer folicular de tiroides

Cáncer medular de tiroides

Cáncer anaplásico de tiroides

Patología Quirúrgica de Tiroides:

Bocio multi nodular no toxico sintomático  

Bocio multi nodular toxico

Hipertiroidismo

Hiperparatiroidismo:

Hiperparatiroidismo primario

Hiperparatiroidismo secundario

Hiperparatiroidismo terciario

Tumores de Cabeza y Cuello:

Cáncer de la cavidad oral

Cáncer de faringe:

Nasofaringge

Orofaringe

Hipofaringe

Cáncer Laringeo:

Cáncer supraglótico

Cáncer glótico

Cancer subglótico

Cáncer de glándulas salivales:

Glándula Parótida

Glándula submandibular

Glándula sublingual

Glándulas salivales menores

Cáncer de piel de la cabeza y cuello:

Melanoma

Carcinoma basocelular

Carcinoma epidermoide

Carcinoma de Merkel

Dermatofibrosacroma Protuberans

Cáncer de Mama. 

Cáncer de piel:

Melanoma

Carcinoma basocelular

Carcinoma epidermoide

Carcinoma de Merkel

Dermatofibrosacroma Protuberans

Fue entrenado en las mejores instituciones académicas de los Estados Unidos.

Mantiene certificaciones por los Consejos de Cirugía General y Cirugía Oncológica en México y en los Estados Unidos de América. ​  

Su entrenamiento incluyó:

Cirugía General y Gastrointestinal:

Michigan State University (2004 – 2010)

  Cirugía Oncológica / Tumores de Cabeza y Cuello / Cirugía Endocrina:

Fox Chase Cancer Center en Filadelfia (2010 al 2012)

  Maestría en Ciencias (Clinical Research for Health Professionals):

Drexel University (Filadelfia) (2010 – 2012)

  Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina (2014 al 2016):

IFHNOS / Memorial Sloan Kettering Cancer Center

  Ha participado en múltiples cursos y congresos como Conferencista y Profesor Invitado, así mismo ha realizado diversas publicaciones y artículos sobre temas relacionados con su especialidad.

Es pionero en México de la:

Cirugía minimamente invasive radioguida de paratiroides.

Se encuentra certificado por el Consejo Mexicano de Cirugía General y el Consejo Mexicano de Oncología así como es de los pocos mexicanos certificado por, el AMERICAN BOARD OF SURGERY,  el cuál le faculta como cirujano con licencia en los EU.

Es miembro de diversas asociaciones médicas como el:

American College of Surgeons, American Thyroid Association, American Society of Endocrine Surgeons, American Medical Association, American Society of Clinical Oncology, Association of Academic Surgeons, Society of Surgical Oncology,  The Society of Surgery of the Alimentary Tract, Society of American Gastrointestinal Endoscopic Surgeons, y la American Society of Breast Surgeons, entre otras.

Gracias a esto el Dr. Rodrigo Arrangoiz es reconocido como uno de los mejores especialistas en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica en México, además de ser galardonado como uno de los 50 mejores médicos de México en los Top Doctors Awards 2018.

#Arrangoiz

#Teacher

#Surgeon

#Cirujano

#ThyroidExpert

#ThyroidSurgeon

#CirujanodeTiroides

#ExpertoenTiroides

#ExpertoenParatiroides

#Paratiroides

#Hiperparatiroidismo

#CancerdeTiroides

#ThyroidCancer

#PapillaryThyroidCancer

#SurgicalOncologist

#CirujanoOncologo

#CancerSurgeon

#CirujanodeCancer

#HeadandNeckSurgeon

#CirugiaEndocrina

#CirujanodeTumoresdeCabezayCuello

#OralCavityCancer

#Melanoma

Visite sus paginas:

http://www.cirugiatiroides.com

http://www.hiperparatiroidismo.info

https://www.topdoctors.mx/doctor/rodrigo-arrangoiz-m-s-m-d-f-a-c-s

https://www.linkedin.com/in/rodrigo-arrangoiz-ms-md-facs-7624b779/?originalSubdomain=mx

  Cirujano de Cabeza y Cuello / Head and Neck Surgeon Rodrigo Arrangoiz MS, MD, FACS es especialista en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica compleja: …

[arrangoiz]

The larynx is an inferior continuation of the oropharynx:

It extends from the epiglottis (namely the glossoepiglottic and pharyngoepiglottic folds) to the inferior aspect / border of the cricoid cartilage.

Inferiorly:

It continues as the cervical trachea. 

Gross anatomy:

The larynx consists of a cartilage “skeleton”, as well as internal structures that are divided into three subsites, mainly for the purposes of laryngeal cancer staging:

Supraglottis:

Which extends from the tip of the epiglottis to the laryngeal ventricle

Subsites:

Epiglottis:

Divided into suprahyoid and infrahyoid portions

Pre-epiglottic space

Arytenoid cartilages

Aryepiglottic folds

Ventricles

False vocal cords

Paraepiglottic space

Glottis

True vocal cords

Anterior commissure

Posterior commissure

Subglottis:

Extends from the inferior surface of the true vocal cords / 5mm below the free margin of the true vocal cord to the inferior aspect / lower border of the cricoid cartilage

Relations:

Anterior:

Strap muscles

Anterior jugular vein

Posterior:

Esophagus

Laryngopharynx

Superior:

Hyoid bone

Laryngopharynx

inferior:

Trachea

Arterial supply:

Above the vocal cords:

Superior laryngeal artery:

Branch of the superior thyroid artery

Below the vocal cords:

Inferior laryngeal artery:

Branch of the inferior thyroid artery

Venous drainage

Above the vocal cords:

Superior laryngeal vein accompanies its artery and drains into the superior thyroid vein:

A tributary to the internal jugular vein

Below the vocal cords:

Inferior laryngeal vein accompanies its artery and drains into the inferior thyroid vein:

A direct tributary to the brachiocephalic vein

Lymphatic drainage:

Supraglottic:

The supraglottic lymphatic network follows the superior laryngeal artery:

Piercing the thyrohyoid membrane and then draining into the superior deep cervical nodes and the pre-epiglottic nodes. 

Subglottic:

The infraglotttic lymphatic network drains to the inferior deep cervical nodes, following the inferior laryngeal artery, and/or the prelaryngeal (Delphian) nodes via the conus elasticus (aka the lateral cricothyroid ligaments). 

Both the superior and inferior deep cervical nodes then drain into the right and left jugular trunks:

Which subsequently empty into the right lymphatic duct and the thoracic duct on the left. 

Innervation:

Motor:

The recurrent laryngeal nerve supplies all the intrinsic muscles of the larynx apart from the cricothyroid muscle:

Which is supplied by the external branch of the superior laryngeal nerve.

Sensory: 

Above the vocal cords (supraglottic):

Internal branch of the  superior laryngeal nerve

Below the vocal cords (infraglottic):

Recurrent laryngeal nerve

Development:

The larynx is formed from the laryngotracheal groove:

Which is related to the caudal aspect of the floor of the primordial pharynx

The cartilages of the larynx develop from:

The 4th and 6th pharyngeal arches

Staging of Laryngeal Cancer

T Category

T Criteria

Reprinted with permission from AJCC: Larynx. In: Amin MB, Edge SB, Greene FL, et al., eds.: AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer, 2017, pp 149–61.

TX Primary tumor cannot be assessed. Tis Carcinoma in situ.

Supraglottis

T1 Tumor limited to one subsite of supraglottis with normal vocal cord mobility. T2 Tumor invades mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e.g., mucosa of the base of the tongue, vallecula, medial wall of pyriform sinus) without fixation of the larynx. T3 Tumor limited to larynx with vocal cord fixation and/or invades any of the following: post-cricoid area, pre-epiglottic space, para-glottic space, and/or inner cortex of thyroid cartilage. T4 Moderately advanced or very advanced. T4a Moderately advanced local disease.    Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). T4b Very advanced local disease.                Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.

Glottis

T1 Tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility. T1a Tumor limited to one vocal cord. T1b Tumor involves both vocal cords. T2 Tumor extends to supraglottis and/or subglottis, and/or with impaired vocal cord mobility. T3 Tumor limited to the larynx with vocal cord fixation and/or invasion of paraglottic space and/or inner cortex of the thyroid cartilage. T4 Moderately advanced or very advanced. T4a Moderately advanced local disease.    Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, cricoid cartilage, soft tissues of the neck including deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). T4b Very advanced local disease.               Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.

Subglottis

T1 Tumor limited to the subglottis. T2 Tumor extends to vocal cord(s) with normal or impaired mobility. T3 Tumor limited to the larynx with vocal cord fixation and/or invasion of paraglottic space and/or inner cortex of the thyroid cartilage. T4 Moderately advanced or very advanced. T4a Moderately advanced local disease.    Tumor invades cricoid or thyroid cartilage and/or invades tissues beyond the larynx (e.g., trachea, soft tissues of the neck including deep extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). T4b Very advanced local disease.                Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures.

  Rodrigo Arrangoiz MS, MD, FACS es especialista en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica compleja:Fue egresado como Médico General de la Universidad Anahuac:Graduado Suma Cum Laude. Es miembro de Sociedad Quirúrgica S.C.:Que es el único grupo quirúrgico en México en donde todos los socios se entrenaron en las mejores instituciones académicas de los Estados Unidos de América. 

El Doctor Arrangoiz es experto en el manejo del: Cáncer de Tiroides:Cáncer papilar de tiroides

Cáncer folicular de tiroides

Cáncer medular de tiroides

Cáncer anaplásico de tiroides

Patología Quirúrgica de Tiroides:Bocio multi nodular no toxico sintomático  Bocio multi nodular toxico

Hipertiroidismo

Hiperparatiroidismo:Hiperparatiroidismo primarioHiperparatiroidismo secundario

Hiperparatiroidismo terciario

Tumores de Cabeza y Cuello:Cancer de la cavidad oral

Cáncer de faringe:

Nasofaringe

Orofaringe

Hipofaringe

Cáncer Laringeo:

Cáncer supraglótico

Cáncer glótico

Cancer subglótico

Cáncer de glándulas salivales:

Glándula Parótida

Glándula submandibular

Glándula sublingual

Glándulas salivales menores

Cáncer de piel de la cabeza y cuello:

Melanoma

Carcinoma basocelular

Carcinoma epidermoide

Carcinoma de Merkel

Dermatofibrosacroma Protuberans

Cáncer de Mama. 

Cáncer de piel:

Melanoma

Carcinoma basocelular

Carcinoma epidermoide

Carcinoma de Merkel

Dermatofibrosacroma Protuberans

Fue entrenado en las mejores instituciones académicas de los Estados Unidos.

Mantiene certificaciones por los Consejos de Cirugía General y Cirugía Oncológica en México y en los Estados Unidos de América.   

Su entrenamiento incluyó:Cirugía General y Gastrointestinal:Michigan State University (2004 – 2010)

  Cirugía Oncológica / Tumores de Cabeza y Cuello / Cirugía Endocrina:Fox Chase Cancer Center en Filadelfia (2010 al 2012)

  Maestría en Ciencias (Clinical Research for Health Professionals):Drexel University (Filadelfia) (2010 – 2012)

  Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina (2014 al 2016):IFHNOS / Memorial Sloan Kettering Cancer Center

  Ha participado en múltiples cursos y congresos como Conferencista y Profesor Invitado, así mismo ha realizado diversas publicaciones y artículos sobre temas relacionados con su especialidad.

Es pionero en México de la:

Cirugía minimamente invasive radioguida de paratiroides.

Se encuentra certificado por el Consejo Mexicano de Cirugía General y el Consejo Mexicano de Oncología así como es de los pocos mexicanos certificado por, el AMERICAN BOARD OF SURGERY,  el cuál le faculta como cirujano con licencia en los EU.

Es miembro de diversas asociaciones médicas como el:American College of Surgeons, American Thyroid Association, American Society of Endocrine Surgeons, American Medical Association, American Society of Clinical Oncology, Association of Academic Surgeons, Society of Surgical Oncology,  The Society of Surgery of the Alimentary Tract, Society of American Gastrointestinal Endoscopic Surgeons, y la American Society of Breast Surgeons, entre otras.

Gracias a esto el Dr. Rodrigo Arrangoiz es reconocido como uno de los mejores especialistas en Cirugía de Tumores de Cabeza y Cuello / Cirugía Endocrina y Cirugía Oncológica en México, además de ser galardonado como uno de los 50 mejores médicos de México en los Top Doctors Awards 2018.

#Arrangoiz

#Teacher

#Surgeon

#Cirujano

#ThyroidExpert

#ThyroidSurgeon

#CirujanodeTiroides

#ExpertoenTiroides

#ExpertoenParatiroides

#Paratiroides

#Hiperparatiroidismo

#CancerdeTiroides

#ThyroidCancer

#PapillaryThyroidCancer

#SurgicalOncologist

#CirujanoOncologo

#CancerSurgeon

#CirujanodeCancer

#HeadandNeckSurgeon

#CirugiaEndocrina

#CirujanodeTumoresdeCabezayCuello

#OralCavityCancer

#Melanoma

Anatomy and Staging of Laryngeal Cancer The larynx is an inferior continuation of the oropharynx: It extends from the epiglottis (namely the glossoepiglottic and pharyngoepiglottic folds) to the inferior aspect / border of the…

[arrangoiz]

Merkel cell carcinoma (MCC) is the eponym for :

Primary cutaneous neuroendocrine carcinoma:

A dermal neoplasm with cytoplasmic, dense-core neuroendocrine granules and keratin filaments. 

MCC is a rare primary cutaneous neuroendocrine malignancy

The incidence of MCC in the United States has recently been reported to have increased by an estimated annual percentage change of 8% from 1986 to 2001:

Approximately 1500 new cases were predicted by the American Cancer Society in the United States alone in 2008. 

MCC is one of the few cancers found to be:

Associated with immune suppression

Polyomavirus has been shown to be integrated within the genome

Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm that lacks distinguishing clinical features. 

More than half of Merkel cell carcinomas (MCCs) occur in the head and neck of elderly people in areas of actinically damaged skin:

The most common site of occurrence is the periorbital region. 

Merkel cell carcinoma (MCC) has a propensity to recur and to cause:

Local (25% to 30% of the cases) and distant metastases (30% to 35% of the cases). 

Distant metastases indicate a condition that is nearly always fatal.

Merkel cell carcinoma (MCC) is a deadly disease with a poor likelihood for survival:

Local recurrence occurs in:

44% of patients:

Multiple local recurrences occur in 15% of patients. 

These tumors appear as:

Rapidly growing, painless nodules in elderly caucasian individuals or in young adults with ectodermal dysplasia syndromes. 

Merkel cell carcinomas (MCCs) usually appear as:

Indurated plaques or violaceous (red or deep purple) solitary and dome-shaped nodules. 

The surface is typically shiny, with telangiectasias and possibly ulceration. 

Most tumors measure 0.7 cm to 1.2 cm in diameter.

Merkel cell carcinomas (MCCs) usually occur in sun-damaged skin. 

They are often found near other lesions of actinically damaged skin, including skin involved with:

Bowen disease, squamous cell carcinoma, basal cell carcinoma, solar keratoses, or lentigo maligna. 

The mean age at presentation is 68 years:

No gender bias is observed. 

Merkel cell carcinoma (MCC) has also been linked to:

Previous radiation exposure and B-cell lymphoma.

The nonspecific characteristics of Merkel cell carcinoma (MCC) lead to a lengthy differential diagnosis that includes:

Basal cell carcinoma

Squamous cell carcinoma

Keratoacanthoma

Amelanotic melanoma

Epidermal cysts

Lymphoma

Metastatic carcinoma of the skin

As a result:

Merkel cell carcinoma (MCC) is rarely diagnosed until biopsy is performed

Approximately 53% of Merkel cell carcinomas (MCCs) occur in the head and neck:

35% occur in the extremities. 

In the head and neck:

46% of tumors occur in the periorbital region

29%, on the cheek

18%, on the eyelid

17%, on the forehead. 

Other sites in the head and neck include:

The lips (9%)

Ears (7%)

Nose and neck (5.4%)

Scalp (4%)

Tumors have also been reported in areas not exposed to sun, such as the:

Nasal cavity

Buccal mucosa

Gingiva

Hard palate

Postauricular skin

Approximately 3% of patients with Merkel cell carcinoma (MCC) have tumors at several sites. 

MCC is an aggressive tumor:

With an overall five-year survival of 40%

Reported five year survival rates of local, nodal and metastatic disease are:

64%, 39% and 18%, respectively

Reported rates of regional lymph node involvement at the time of presentation vary from 10% to 45%:

Around 50% of patients with lymph node metastases harbor concurrent distant metastases:

Most often in the:

Liver, lung, brain, bone or skin

MCC has high rates of local recurrence:

25% to 30% of patients.

MCC has high rates of distant metastasis:

30% to 35% of patients.

  Rodrigo Arrangoiz MS, MD, FACS a head and neck surgeon / endocrine surgeon / surgical oncologist and is a member of Sociedad Quirúrgica S.C at the America British Cowdray Medical Center in Mexico City:

He is an expert in the management Merkel Cell Carcinoma.

Training:

• General surgery:

• Michigan State University:

• 2004 al 2010

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• Fox Chase Cancer Center (Filadelfia):

• 2010 al 2012

• Masters in Science (Clinical research for health professionals):

• Drexel University (Filadelfia):

• 2010 al 2012

• Surgical Oncology / Head and Neck Surgery / Endocrine Surgery:

• IFHNOS / Memorial Sloan Kettering Cancer Center:

• 2014 al 2016

#Arrangoiz#Teacher

#Surgeon

#Cirujano

#ThyroidExpert

#ThyroidSurgeon

#CirujanodeTiroides

#ExpertoenTiroides

#ExpertoenParatiroides

#Paratiroides

#Hiperparatiroidismo

#CancerdeTiroides

#ThyroidCancer

#PapillaryThyroidCancer

#SurgicalOncologist

#CirujanoOncologo

#CancerSurgeon

#CirujanodeCancer

#HeadandNeckSurgeon

#CirugiaEndocrina

#EndocrineSurgery

#CirujanodeCabezayCuello

http://www.cirugiatiroides.com

http://www.sociedadquirurigca.com

http://www.hiperparatiroidismo.info

Merkel Cell Carcinoma (MCC) Merkel cell carcinoma (MCC) is the eponym for : Primary cutaneous neuroendocrine carcinoma: A dermal neoplasm with cytoplasmic, …