#octips

[wellerdanny]

HAPPY BIRTHDAY DEARIEEE

Happy b-day octipity TT.TT wish you a pleased timeeeedursruarusru😭♥︎♥︎♥︎

I couldn't help but I wanted to give Floyd a "shrimp mark" too

Ace if u need anything you should say it 😔

[valkyriefreia]

Here are my 3 essentials when designing characters for stories! 🌸 An interesting backstory 🌸 A simple concept to build upon 🌸 A design process that I myself enjoy You can have the most pretty or intricately designed character, but they only come alive when you give them a life! Otherwise they are just pure aesthetic (just like my calm girls series! xD) Do you have an original character? I'd love to hear about them in the comments! #octips #ocart #occhallenge #originalcharacter #animestyle #originalcharacterstory #storyideas #designingcharacters #characterdesign #characterdesigntips #digitalart #digitalillustration #digitalartwork https://www.instagram.com/p/CQiyuCbBswD/?utm_medium=tumblr

[harmonytre-reblogs]

!!!!!!!!

Some information that might be helpful to people designing gems. There are many places you can put a gem. Some you may not have thought of, and some you should not do. The placement of the gem can have meaning. And so can the shape.

[mudstoneabyss]

cute octiper theme park date hcs (these are based on universal bcause ive never been to anywhere else)

octavian’s never been on a rollercoaster before so piper insists on dragging him onto e v e r y t h i n g

tav is scared out of his mind he doesn’t trust science and is certain that he will die on the big ones

because of that they start with smaller ones like simulators

tav still screams

even when there’s nothing to scream at

pipes finds this hilarious but is still v reassuring to him

 “babe it’s not that far of a drop ur not gonna die spiderman won’t let u”

there’s a lot of hand holding, mostly because if octavian’s gonna die he’s taking piper with him

they end up buying an excessive amount of slytherin merch because they’re rich nerds

piper end up giving him her jacket before they go on the big rollercoasters for even more reassurance

lots more screaming

its all screaming

octavian does insist on going on them again despite his legs barely being able to hold him up from how shaky he is

they eat a lot of candyfloss to make up for tavi losing bits of his soul on each ride

*cliche top of ferris wheel kiss*

“im going to win you a million plushies” “well, i want a billion plushies” “well, that’s a little unrealistic”

they go on the same water ride (popeye) 10 times because that’s octavian’s favourite and isn’t that scary

overall they both loved it and agree that they’re going to Disney

[octittyan]

one of the only reasons i could see octiper is look me In The Face and tell me it’s possible for someone to dislike piper mclean

[bryabdad26]

Some people believe an octopus can change its color to match it's surroundings, but that's an octipal illusion.

[tsunflowers]

unknown fuck list

el of the water: 1

el of the wind: 3

el of the ground: 2

pantheras luteus: 2

pantheras albus: 2

pantheras tristis: 3

pantheras rubeo: 3

pantheras cyaneus: 2

pantheras magistra: 1

testudo oceanus: 3

testudo terrestris: 3

anguis masculus: 2

anguis femineus: 1

corvus croccio: 3

corvus luscus: 3

corvus intonsus: 2

corvus calvus: 3

corvus canosus: 2

equus noctis: 3

equus dies: 3

skelos falx: 1

skelos glaucus: 2

apis vespa: 3

apis mellitus: 1

potamotrigon cucullus: 3

potamotrigon cassis: 3

piscis arapalma: 1

piscis serratus: 2

stellio dextera: 1

stellio sinistra: 1

formica pedes: 3

formica eques: 3

formica regia: 1

mollipes octipes: 4

leiurus acutia: 2

hydrozoa ignio: 4

echinus famelicare: 2

crustata paleo: 3

cetos orcinus: 1

propheta cruentus: 4

scarabaeus fortis: 1

volucris ulucus: 3

volucris falco: 3

ericius liquor: 1

1: would absolutely fuck it

2:  would take a little convincing to fuck it

3: would take a lot of convincing to fuck it

4: would not fuck it

[backtornado]

burnttoastmaster replied to your post: you cowards all unknown are sexy except the...

i dont know what any of them really look like but i probably agree

they’re a spicy bunch with the spiciest of them all being one big angry birdman:

a small extra friend:

and just for good measure, here’s the horror that is Mollipes Octipes, the only unsexy unknown:

[tumimmtxpapers]

Dynamics of the Intratumoral Immune Response during Progression of High-Grade Serous Ovarian Cancer.

Dynamics of the Intratumoral Immune Response during Progression of High-Grade Serous Ovarian Cancer. Neoplasia. 2018 Feb 18;20(3):280-288 Authors: Stanske M, Wienert S, Castillo-Tong DC, Kreuzinger C, Vergote I, Lambrechts S, Gabra H, Gourley C, Ganapathi RN, Kolaschinski I, Budczies J, Sehouli J, Ruscito I, Denkert C, Kulbe H, Schmitt W, Jöhrens K, Braicu I, Darb-Esfahani S Abstract PURPOSE: Tumor-infiltrating lymphocytes (TILs) have an established impact on the prognosis of high-grade serous ovarian carcinoma (HGSOC), however, their role in recurrent ovarian cancer is largely unknown. We therefore systematically investigated TIL densities and MHC class I and II (MHC1, 2) expression in the progression of HGSOC. EXPERIMENTAL DESIGN: CD3+, CD4+, CD8+ TILs and MHC1, 2 expression were evaluated by immunohistochemistry on tissue microarrays in 113 paired primary and recurrent HGSOC. TILs were quantified by image analysis. All patients had been included to the EU-funded OCTIPS FP7 project. RESULTS: CD3+, CD4+, CD8+ TILs and MHC1 and MHC2 expression showed significant correlations between primary and recurrent tumor levels (Spearman rho 0.427, 0.533, 0.361, 0.456, 0.526 respectively; P http://dlvr.it/QHQbGh

[cuddlecouchcollection-blog]

Adding my Inktober drawings to this account as well! This is day one which was "swift" which apparently equals prosthetic having hare racer...idk but I like it! Keep up with me all octiper, hopefully this will mean more art in the long run

[cancersfakianakis1]

Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy–Innovative Models Prolong Survival (OCTIPS) Consortium

Publication date: July 2017 Source:European Journal of Cancer, Volume 79 Author(s): Ilary Ruscito, Dan Cacsire Castillo-Tong, Ignace Vergote, Iulia Ignat, Mandy Stanske, Adriaan Vanderstichele, Ram N. Ganapathi, Jacek Glajzer, Hagen Kulbe, Fabian Trillsch, Alexander Mustea, Caroline Kreuzinger, Pierluigi Benedetti Panici, Charlie Gourley, Hani Gabra, Mirjana Kessler, Jalid Sehouli, Silvia Darb-Esfahani, Elena Ioana Braicu BackgroundHigh-grade serous ovarian cancer (HGSOC) causes 80% of all ovarian cancer (OC) deaths. In this setting, the role of cancer stem-like cells (CSCs) is still unclear. In particular, the evolution of CSC biomarkers from primary (pOC) to recurrent (rOC) HGSOCs is unknown. Aim of this study was to investigate changes in CD133 and aldehyde dehydrogenase-1 (ALDH1) CSC biomarker expression in pOC and rOC HGSOCs.MethodsTwo-hundred and twenty-four pOC and rOC intrapatient paired tissue samples derived from 112 HGSOC patients were evaluated for CD133 and ALDH1 expression using immunohistochemistry (IHC); pOCs and rOCs were compared for CD133 and/or ALDH1 levels. Expression profiles were also correlated with patients' clinicopathological and survival data.ResultsSome 49.1% of the patient population (55/112) and 37.5% (42/112) pOCs were CD133+ and ALDH1+ respectively. CD133+ and ALDH1+ samples were detected in 33.9% (38/112) and 36.6% (41/112) rOCs. CD133/ALDH1 coexpression was observed in 23.2% (26/112) and 15.2% (17/112) of pOCs and rOCs respectively. Pairwise analysis showed a significant shift of CD133 staining from higher (pOCs) to lower expression levels (rOCs) (p < 0.0001). Furthermore, all CD133 + pOC patients were International Federation of Gynaecology and Obstetrics (FIGO)-stage III/IV (p < 0.0001) and had significantly worse progression-free interval (PFI) (p = 0.04) and overall survival (OS) (p = 0.02). On multivariate analysis, CD133/ALDH1 coexpression in pOCs was identified as independent prognostic factor for PFI (HR: 1.64; 95% CI: 1.03–2.60; p = 0.036) and OS (HR: 1.71; 95% CI: 1.01–2.88; p = 0.045). Analysis on 52 pts patients with known somatic BRCA status revealed that BRCA mutations did not influence CSC biomarker expression.ConclusionsThe study showed that CD133/ALDH1 expression impacts HGSOC patients' survival and first suggests that CSCs might undergo phenotypic change during the disease course similarly to non stem-like cancer cells, providing also a first evidence that there is no correlation between CSCs and BRCA status. http://ift.tt/2ripN97

[octittyan]

Favorite headcanon for all Octavian ships if you’re up to it?

aright he we go how much is all skjdlkdfjldk

octkahale:

they’re each other’s best friend and the people they trust the most. they both care for each other so much and they mean the world to the other

jastavian:

they were best friends when they were younger and even had crushes on each other but grew apart over time. they still have feelings for each other within the tension between them

pertavian:

octavian got a crush on percy basically as soon as he saw him. later on they’d end up getting along more than they thought they would and realize that they have a lot in common and experiences that no one else they met could relate to

leotavian:

they both felt pretty alone and over time they help each other realize that people care about them even when they feel alone

franktavian:

they’re an “opposites attract” scenario. frank is soft, kind, and an optimist. octavian is bitter, rough, and expects the worst out of everything. they balance each other out.

ethtavian:

they both feel horrible for their mistakes. to themselves, they are villains who only hurt people, but they insist that the other person isn’t

dakotavian:

they have huge crushes on each other but will not admit it. they joke together a lot and sometimes do some possibly alcohol related things, possibly kiss or more sometimes, but insist they do not like each other

gwevian:

they’re huge friends who may not seem like they get along if you don’t know their relationship. the way they joke with each other makes it seem like they can’t stand the other but in actuality it’s just their sense of humour

drewtavian:

drew loves dressing octavian up in the most cutesy pastel and somewhat revealing outfits and tav Doesn’t Understand but drew finds how awkward and blushy he is in them adorable

octiper:

at first octavian wanted to hate piper but he just couldn’t because how the fuck can you dislike piper mclean. she was one of the few people who wasn’t immediately mean to him, and he find her incredibly charming all the time, whether it’s her flirting with him or her snorting while laughing at a dick joke she made

[octittyan]

This is the Gwen anon and honestly. Gwen/Octavian is the only het ship I’ll accept of him. Drew/Octavian is maybe ok but it’s on Thin Ice. Though I also like thinking about both of those as just. Wlw/mlm Solidarity. Because Drew’s a lesbian and Gwen’s Pan but like I said. Personally those are the ones That don’t bother me. (And if course there’s no content but oof)

i can understand this