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dailyhogwartsgazette · 1 year ago
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Breakthrough Cancer Treatment: UK Scientists Unveil Remarkable New Drug
Scientists in the United Kingdom have made a groundbreaking discovery with a new drug that promises a revolutionary breakthrough in the treatment of a hard-to-manage and aggressive form of cancer. The development, hailed as “truly wonderful,” comes from researchers at Queen Mary University London, who have reported that their innovative treatment has quadrupled three-year survival rates and…
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In 2017 I interviewed Bernadette Wren, then head of psychology at the Tavistock Gids clinic, and asked what effect puberty blocking drugs have on the adolescent brain. Looking highly uncomfortable, she replied that the evidence so far was only anecdotal but that the clinic would study its patients “well into their adult lives so that we can see”.
Even back then, before whistleblowers had exposed the rush to medically transition children, it was alarming to hear that heavy-duty GnRH agonists such as triptorelin — used to treat advanced prostate cancer and “chemically castrate” sex offenders — were being prescribed to arrest puberty in hundreds of children as young as 11.
Moreover, they were being used “off-label” before any clinical trials. And the long-term study Wren promised never materialised: Gids (the Gender Identity Development Service) routinely lost touch with patients, and the 44 it did follow reported little long-term mental health improvement.
This shocking chapter in medical history, where the ideological objectives of trans rights campaigners trumped the welfare of disturbed children, is coming to an end worldwide. The decision by NHS England effectively to ban the prescription of puberty blockers comes after the Cass review noted these drugs could “permanently disrupt” brain development, reduce bone density and lock children into a regime of cross-sex hormones requiring life-long patienthood.
NHS England unites with other national health services including those in Finland, France, Sweden and, most notably, the Netherlands — where the “Dutch protocol”, a regime of early blockers then hormones, was devised in 1998 — in pulling back from prescribing them.
Even in the United States, where a toxic combination of extreme activism and medical capitalism has pushed child gender medicine to grotesque extremes, with double mastectomies performed on 14-year-old girls, there is some retrenchment.
Leaks from the World Professional Association for Transgender Health, the body which formulates guidance on “trans healthcare”, reveal doctors perplexed at how they should explain to an 11-year-old child that drugs will render them infertile. Crucially, liberal media such as The New York Times are now reporting grave medical misgivings about child transition, once dismissed as a culture-war issue for the Republican right.
Yet the question remains: how was this ever allowed to happen? For years, puberty blockers were cheerily billed as a mere “pause button”. In 2014, Dr Polly Carmichael, the last head of Gids before the Cass review ordered its closure, went on CBBC in a show called I Am Leo, saying of blockers: “The good thing is, if you stop the injections, it’s like pressing ‘start’ and the body carries on developing as it would if you hadn’t started.”
The BBC permitted her to make this unevidenced claim to an impressionable audience of six to 12-year-olds. Imagine hearing this as a developing girl, freaked out by your new breasts and periods. No wonder Gids referrals subsequently rocketed.
Carmichael failed to mention that she did not know if pressing “restart” on puberty is always medically possible — it is not — and in fact, almost every child Gids put on blockers went on to irreversible cross-sex hormones.
After years in a Peter Pan state while their peers developed, they understandably felt there was no way back and forged on with treatment. Yet if allowed to experience natural puberty, almost 85 per cent of gender dysphoria cases resolve themselves.
Nor did Carmichael tell CBBC kids that the blockers-hormones combination, if taken early enough, not only results in sterility but kills the libido so that a young person will never experience an orgasm.
At the 2020 judicial review brought by a former Tavistock clinician and Keira Bell, the brave young detransitioner rushed onto hormones by Gids, judges expressed astonishment at Gids’s lack of an evidence base.
Reporting on this issue for seven years, I too have been struck by a complete clinical incuriosity. Not only was data not collected, but those who queried treatments or pressed for evidence faced angry condemnation. Perhaps activists knew what research might find because one long-term Finnish study, recently reported in the BMJ, destroyed the myth used to justify blockers: that a child will commit suicide if denied them.
The Finns found that “gender-affirming care” does not make a dysphoric child less suicidal. Rather, such children had the same suicide risk as others with severe psychiatric issues. In other words, changing bodies does not fix troubled minds.
Yet even after NHS England’s announcement, activists refuse to heed the now-overwhelming evidence. In its response, Stonewall persists with the myth that puberty blockers “give a young person extra time to evaluate their next steps”.
Many questions remain unanswered: will private clinics still be permitted to prescribe puberty blockers; and is Scotland’s Sandyford child gender clinic still determined to close its ears to all evidence? Plus, we have few details on how the NHS’s new “holistic” treatment for gender-questioning children will operate when it opens next month.
This repellent experiment — in which girls who like trucks or little boys who dress as princesses, and who invariably grow up to be gay, are corralled inexorably down a road towards life-changing treatments — belongs in the book of medical disgraces. As do the cheerleaders who raised money for Mermaids and those who persecuted whistleblowers or damned journalists asking questions as transphobic.
In 50 years, chemically freezing the puberty of healthy children with troubled minds will be regarded with the same horrified fascination as lobotomies — which, never forget, won the Portuguese neurologist Antonio Egas Moniz the 1949 Nobel prize.
--------------------
{Article source (behind paywall)}
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sitepathos · 6 months ago
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Wow, I loved chapter 11! Would be funny if batfam discovered a cure for cancer trying to figure out how to deal with the mold, was just a thought that stuck in my head when I read the description 'benign tumor'. Would also be a good way for batfam to start dealing with the PR nightmare this is turning into. Has Bruce been trying to fuck over Lex? Also was wondering if maybe Gould made any bonds in the four years back home? Is there any jealousy rising in batfam from a brotherly or fatherly bond they discover, or has he mostly been keeping to himself? Either way, I'm excited to see what's coming up with this next confrontation, hope the inspiration narwhal visits you!
Yeah, I can see them using their discoveries to change public opinion about them.
Now, they know the Megamycete is similar to a benign cancer that eradicates native cells and replaces them with unstable mold versions, but since they only have the one sample of your blood (and it’s kinda lost all viability due to the batter of tests its been subjected to), they’re still far from discovering any usable weapon to attack the Megamycete at the cellular level.
While their tests have yielded nothing to combat the mold, their failures have led to the discovery of a treatment that’s highly effective against actual cancers, tumors, and viral infections. Bruce had the data forwarded to Wayne Pharmaceuticals to begin development of new medicines based off their work, leading to several new drugs being developed that promise to either treat several incurable diseases and illnesses or eliminate them altogether.
It definitely makes people see Bruce Wayne more favorable, but not enough to reverse all the bad publicity done to his company. He’s also made several attempts to get back at Lex for his actions at the gala, both as CEO of Wayne Enterprises by showing him up in business and as Batman by exposing his less-than-legal activities.
He’s actually very grateful to you (despite the fact you’re infected by some sentient mushroom) since it’s helped complete many projects the pharmaceutical division has been working on for years, which will help countless people in the long run.
But make no mistake, he fully intends to find a way to purge the Megamycete from your body. He says it’s because it’s dangerous and that it’s making you act out, but it’s because it gives you the power to oppose him and fight back when he tries to bring you back to Gotham. Let’s be honest, Bruce Wayne is a massive control freak and is used to being the one in total control of every situation and the smartest person in the room and he can’t stand it when he doesn’t have something under control.
Thanks to the Megamycete, you’re not only stronger than him, but smarter, too.
This is a huge no-no and he’ll stop at nothing to correct the situation, under the guise of “helping” you and “bring you back home.”
As for the second part of your ask, I’ve had several people ask about the reader dating/marrying people and making friends; I’ve even made a post about Eveline from Resident Evil 7 being your adoptive daughter, but I don’t have any plans on making a canon family and friends for the reader in the series.
Believe me, you want a family and friends. You’d love to find a man who will give you the love you were denied for so long and maybe even adopt a child (although several people asking about kids has made me think you’d be capable of carrying biological children since you can alter your body due to the Megamycete), but after all that you endured at Wayne Manor, you think you have too much emotional baggage to properly care for a family (not to mention the whole Megamycete situation) and you’re just subject your potential family and friends to the same treatment you were given for most of your life.
Right now, you’re working on yourself. You moved back to Goodsprings immediately after graduating and turned your childhood home into a home you’re really proud of and now with the ulcers of Salvage Rights, you’re seeing a small fortune building before your eyes (of course, you still have most of the money you got from Lex for seeking WE secrets).
Of course, Bruce and his children had to show up out of nowhere and reset all the progress you made in the last four years and making people stare at you every time you walk into a room and whisper about you when they think you can’t hear them.
So, any plans you had on making a family and finding friends are on hold for right now. You just have to take care for your little bat problem.
But, let’s say you did have a family and friends. That not long after you moved to Goodsprings, you made a few friends either in town or in the surrounding area, which eventually lead to you finding a boyfriend and after two years of dating, you got married (Alfred attended, he wouldn’t miss it for the world).
Now, he didn’t tell them about the wedding at the time, but after the four year mark of you leaving Gotham, he reminded them that you exist and dropped the bombshell that you’re married.
This leads to every one of them going berserk.
You’re married?! And they weren’t invited to the wedding?!
They immediately dislike your husband, Bruce especially since he has the insane belief that as your father, any man should ask for his blessing to date/marry you (of course he’d turn down any request before it even leaves the man’s mouth).
“There’s no man in this world that’s good enough for you, Y/N. Besides, you only need me and your brothers.”
Damian is in the same boat as he believes very few are worthy enough of joining the Wayne legacy.
“Our bloodline is a sacred one, brother, and we must be selective of who is a part of it. If you insist on finding a mate, I’m sure Father would be capable of finding one for you. But you needn’t worry over that, I’m more than capable of continuing the family in his stead.”
Dick would lose his shit if he hears that you have a husband.
“He just proposes to you? Without asking to meet your family? That’s very suspicious, baby bird! He clearly wants to take you away from us!”
Jason would be silent during the entire ordeal, but he’d stand there, glaring at you poor husband and showing off the gun he has on his hip, filled with real bullets.
Tim’s immediately researching the shit out of this guy, going back to his birth and will use anything and everything he finds to convince you that he’s unfit for you and you should divorce him.
“He got a speeding ticket when he was 16, Y/N! He clearly lives on the edge and doesn’t care about respecting the law! …Why are you staring at me like that for?”
Steph is actually kinda proud of you for causing this kind of chaos in the family. She’s always pulling stunts that cause Bruce’s hair to turn grey and loves messing with everyone, but what you’ve done is nothing short of astounding in her eyes. Of course, she’s just as opposed to the marriage as the others and wants you to divorce your husband and move back home at once.
“Y/N, if you wanted to drive Bruce into an early grave, you could’ve just done what I did and wreck the Batmobile. Hey, we can do that when we get back home!”
Cass actually understands the desire to find love and create a family; thanks to Bruce, she knows what a family is (a lesson you were never taught) and wishes she could find someone to spend her life with. But thanks to her upbringing and her vigilante lifestyle, she knows that’s a pipe dream. Besides, Bruce and her siblings are more than enough.
However, that doesn’t mean she supports the marriage; in fact, she opposes it and believes you must divorce your husband and come home right away. People can’t be trusted and the world is too dangerous. You need to come home where they can protect you.
And god help you if you say your new friends are more like your siblings than them.
As expected, Damian doesn’t take the news well and accuses them of trying to take his place as your true brother (this delusional bastard really believes that after everything, the two of you can really be brothers).
But I think Dick would take the news worse than him; he takes his role as the elder brother of the Wayne children seriously and he doesn’t like the thought of you seeing someone other than him as your big brother. He’d probably cry and beg you to take it back, say you were just lying to hurt him, anything! Just say you don’t see anyone as a big brother!
Lastly, if you have any children, be it through adoption or biological, they immediately stake a claim on them and try to bring them into the family.
That just leaves you, fighting these delusional freaks tooth and nail to keep your friends and family safe. If your husband is a meta, he’ll try to join in, but you insist on dealing with them yourself. You know they’ll use any dirty trick they can find against your husband and you’d rather not put him in any more danger than you have already.
Plus, if anyone has the right to kill them, it’s you. After all they put you through, you’re determined to be the one that finally puts an end to the Bats.
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bloopinggenius · 2 years ago
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☆𝐓𝐨 𝐁𝐞 𝐋𝐨𝐯𝐞𝐝☆| Yautja x 𝘉𝘭𝘢𝘤𝘬 𝘙𝘦𝘢𝘥𝘦𝘳 | M/M/M/M/M x Reader
Chapter 𝐈 | Chapter 𝐈𝐈
ᴡᴀʀɴɪɴɢs**ᴄʜɪʟᴅʜᴏᴏᴅ ᴛʀᴀᴜᴍᴀ,ᴄʜɪʟᴅ ᴀʙᴜsᴇ,ᴅᴇᴘʀᴇssɪᴏɴ,ᴍᴇɴᴛɪᴏɴs ᴏғ ʀᴀᴄɪᴀʟ sʟᴜʀs
╔═══*.·:·.☽✧ ✧☾.·:·.*═══╗
Love was an emotion that Ryia hadn't experienced. She thought that she had from her friends at school, but from what she gathered on the internet and other people, it wasn't. She hadn't felt that sense of warmth through her body when she thought of her friends and she sure didn't from her parents. Her relationship with them was something she would never pray upon her biggest enemy.
When you think of parents, you think of the people who love you, who would protect you in the most dire of situations, sometimes even lay their life down for you but not for Ryia. At the tender age of four, her drug-addict of a mom had burnt her tiny body with scalding hot water almost every three days. It was a hiding game for Ryia. She would be in hiding until she got hungry then proceed to the kitchen to get something to eat, only to not make it out in time where her, already high, mother would find her and beat her. Her father was an absent father. He left the family when Ryia was 2. Now him and his new family are living the high life. Almost every month, they were travelling. Ryia always wondered if that's the reason why her mom abused her. Maybe her mother wanted to travel the world and live the lavish life. But she also couldn't understand why she was being abused. The urge to know the reason of her miserable lifestyle was greater than anything. Sometimes she thought that she was the reason that her mother's dream was hindered. Ryia learnt to look after herself from then on. She went to school with such eagerness, knowing that one day she'd graduate and leave home.
And she did.
Come gradution day and she had graduated and was off to uni on a scholarship. Heaven knows she worked her ass off to become the doctor she was. Even through this, she still helped her mother when she was diagnosed with lung cancer until she passed. Ryia didn't feel anything for the woman, heck she didn't even prepare a funeral. She simply sent her aunt an email regarding her mother's passing and left them to do the rest.
From then on, Ryia mingled around with people who treated like she was the scum of the earth and even had one of her exes call her racial slurs when the relationship ended.
However Ryia was numb to all her bad luck. She never smiled and rarely laughed. Sometimes, looking at her reflection after taking a warm shower, it looked like she was looking through herself, an empty shell with the remnants of it's contents a ghostly appearance. Even with all the money she had, she wasn't happy.
════ ⋆ ⋆ ════
Her life was like this until 𝘁𝗵𝗮𝘁 day. The day she met 𝘁𝗵𝗲𝗺.
It was a chilly night, Ryia reading a book in the quiet of her bedroom. She had been reading Romeo and Juliet. The story not really interesting her. She was just trying to get a feel of their love; trying to gauge what it's like to be in love. She wasn't dumb. She knew lovers never fell this fast in love; she simply was trying to understand 𝗹𝗼𝘃𝗲.
She was so focused in reading her book. So intrigued at the way Shakespeare interpreted love. But nothing could have taken all of her focus to the point that she didn't hear the rumble of an engine outside her house. An engine? Why would there be an engine outside at this time? It was very late into the night, the moonlight stretching itself across her room creating a soft halo around her. She was incredibly startled. Confused and wary, she walked up to window to inspect her backyard. Her chocolate brown eyes scoped the area to find nothing.
Nothing in sight. As she turned to leave, she spotted something. The smallest thing ever, she wasn't even sure she would have seen it, but she did. Under the shadows of the tall trees that surrounded her backyard, she spotted wavy air.
Wavy air. Like the skeptic she is, she blinked, several times but the image never left her sight. She was scared. What could have been going on in her backyard at this time. But with the smallest, ant size of bravery, she decided to go check it out. She hoped that with her knowledge of black people dying first in movies, this wouldn't be that scenario. Walking downstairs was hilarious to her. She didn't crack a smile, no, but she did think that whatever she was doing in that moment was the exact thing the killed the dumbest people in movie.
'But this is real life', she thought. Just to protect herself though, she turned on the living room and kitchen lights. You never know what's lurking in the dark. Ryia walked into the kitchen and opened the cabinet above her stove. She got out a flashlight, the thickest skillet she could find, you know just in case and a large pocket knife. You never know where danger lurks.
After acquiring her items, Ryia cautiously walked out the back door to her backyard. The soft rumbling of the engine had stopped so she turned on the flashlight and walked in the direction that she saw the mysterious 'wavy air'. As she walked closer, flashlight helping with her vision, she noticed the waviness got taller and wider. The more she looked, the more she noticed that something was concealed there but she didn't want to admit it to herself. 'It couldn't be invisible, could it?', her thoughts questioning what she saw. All around her she could her a soft trilling sound. The rapid clicks reminding her of a woodpecker. As she reached out in front of her to feel the mystery object, she felt herself being pushed to the ground at breakneck speed; all her safety objects being thrown out of her hands. Everything was muddled for a second. It took a minute to recover and when she held herself up on her elbows, she looked around frantically. Wondering what the hell was going on, she grabbed the closet thing to her which was her flashlight and searched her backyard.
Ryia got up slowly, sitting on her legs before quickly crawling towards her things so she could return home. Whatever the hell was going on she was leaving it to God and running for her life. After getting back up, she turned towards her house ready to run, only to see the same waviness in front of her. Looking to her left she saw the same one still concealed under the trees. What could possibly be in front of her?
She heard the clicking again only this time it felt like it was two steps in front of her. Her head turned towards the sound slowly and what she saw made her drop her items once again. What was once air, was now something that could only exist in horror movies. In front of her, she saw a massive eight-foot tall humanoid creature. It had a huge crest at the top of it's forehead, two golden deepset eyes, no nose but four crab-like fingers on it's mandible. This creature was fucking huge. It's skin was a chestnut brown with black spotting. It looked like all it ever did was workout it's whole life with it's jacked body. It's taut muscles a canvas with the moonlight enhancing the dips of the muscles on it's torso. It wore silver armor, the most pristine she had ever seen. Nothing seemed off about this alien and she was so close to passing the fuck out.
What she didn't expect was to see four more appear behind the brown one. Each with their own bulky bodies made to perfection. At this point, she knew she was a goner. Each creature was around the same height. At the sight of them, she took a step back. At that moment her life literally flashed before her eyes. It wasn't like her life was special anyway. She knew what she was about to do was stupid but she did it anyway. Or attempted to. She turned on her heels and got two steps away before she was grabbed by her arm and thrown towards the other four. Her body slammed into the floor but it wasn't enough to injure her terribly. Her black curls were a mess around her face and her vision was blurry. She saw the tanned creature walk towards her and that was the last thing she saw.
════ ⋆ ⋆ ════
Ra'kar was the leader of his ship. His ship consisted of himself and four other yautja, all of which are his family. He was nine-hundred and sixty five. Culturally, he was an Elder.
His members were made up of his blood brother, Va'tha and three cousins, T'edqah, Vikap and An'tui. They were currently on a hunt. A forest was their destination but their engine became faulty so they had an emergency stop. Where they wanted to land had looked to be some sort of land near a lake but it happened to belong to a human. They hadn't known that the land was occupied so imagine their surprise when the tiny human emerged from her home in scared curiousity.
Her black locks framed her face and fell down her back in soft curls while she used the light-emitting device to help with her vision. She wasn't small by human standards looking to be atleast 5'11. She was curvy but fit and soft looking. One thing was odd though. Her skin was covered in darker patches and scars howerer that didn't take away from her beauty. Her black skin glowed in the soft glow of the moonlight. She cautiously approached the ship but Vikap being the rebel he is, knocked her to ground. She was frantic for sure, his bio-mask showing her vitals escalating. The five of them jumped down from the trees with such gracefulness, walking towards the fallen human.
Ra'kar was ahead of them, only a few steps away from her and grabbed her before she could escape throwing her towards the others. He didn't mean to throw her hard judging by the way she passed out by their feet. They were all confused at how fragile she was.
An'tui was the youngest and was quiet; very rarely socialising with others. "I think you went a little overboard brother", the burgundy-coloured yautja said.
"What should we do with her?" Va'tha spoke up. The dark green yautja was seven-hundred and forty. Being the brother of an Elder had it's perks as he was a seasoned hunter with many trophies adorning his chamber. He had many strong pups and many more to come with all the females constantly flirting with him. It was uncommon however for pups to be so close like he was with Ra'kar. And he also had a secret; one that could get him outcast. It was wrong and considered unworthy for a yautja to mate or be in a relationship with a human. His hidden desire for humans was buried deep within him years ago but the mere sight of this human had his emotions swirling once again. But he could and would be able to handle his emotions.
"We could just leave her here and continue our journey." Vikap snarled out, glaring at the passed out human.
T'edqah, being the medic that he is, gently picked her up, " Let us take her back to the ship. I must examine her for any injuries as i'm assuming that your intentions were not to hurt her?" With a sigh, Ra'kar agreed and soon after they were on their way.
━━━━━━♡ ♡━━━━━━
Hey guys!!👋 Trying something new. I would really love to make this a series so comment down below and let me know if you guys love this and if I should continue.
Sweet love and Peace✌
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mindblowingscience · 1 year ago
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A drug commonly used to treat type 2 diabetes could also effectively protect against colorectal cancer (CRC), based on a new analysis by researchers in the US. The drug in question is a class of medications known as glucagon-like peptide-1 receptor agonists – more easily referred to as GLP-1 RAs. These medications, which include the widely-known 'wonder drug' sold under the commercial name Wegovy, have also previously been linked to weight loss and reducing the risk of cardiovascular problems.
Continue Reading.
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darkmaga-returns · 5 months ago
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A world-renowned oncologist has confirmed that ivermectin can be used to cure cancer after the top doctor used the wonder drug to treat over 1,000 terminally ill patients.
The announcement was made by Dr. William Makis, a leading Canadian physician with expertise in radiology, oncology, and immunology.
Makis spoke out in a new interview amid a flood of reports from around the world from doctors who are seeing unprecedented results from using a combination of ivermectin and fenbendazole to combat cancer.
The subject recently attracted widespread attention when Hollywood star Mel Gibson dropped a bombshell about the treatment on Joe Rogan’s podcast.
Gibson told Rogan that three of his friends had “stage four cancer.”
However, after being treated with ivermectin and fenbendazole, “all three of them don’t have cancer right now at all.”
“And they had some serious stuff going on,” Gibson emphasized.
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maddmman2 · 5 months ago
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notbeingnoticed · 1 year ago
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In 2017 I interviewed Bernadette Wren, then head of psychology at the Tavistock Gids clinic, and asked what effect puberty blocking drugs have on the adolescent brain. Looking highly uncomfortable, she replied that the evidence so far was only anecdotal but that the clinic would study its patients “well into their adult lives so that we can see”.
Even back then, before whistleblowers had exposed the rush to medically transition children, it was alarming to hear that heavy-duty GnRH agonists such as triptorelin — used to treat advanced prostate cancer and “chemically castrate” sex offenders — were being prescribed to arrest puberty in hundreds of children as young as 11.
Moreover, they were being used “off-label” before any clinical trials. And the long-term study Wren promised never materialised: Gids (the Gender Identity Development Service) routinely lost touch with patients, and the 44 it did follow reported little long-term mental health improvement.
This shocking chapter in medical history, where the ideological objectives of trans rights campaigners trumped the welfare of disturbed children, is coming to an end worldwide. The decision by NHS England effectively to ban the prescription of puberty blockers comes after the Cass review noted these drugs could “permanently disrupt” brain development, reduce bone density and lock children into a regime of cross-sex hormones requiring life-long patienthood.
NHS England unites with other national health services including those in Finland, France, Sweden and, most notably, the Netherlands — where the “Dutch protocol”, a regime of early blockers then hormones, was devised in 1998 — in pulling back from prescribing them.
Even in the United States, where a toxic combination of extreme activism and medical capitalism has pushed child gender medicine to grotesque extremes, with double mastectomies performed on 14-year-old girls, there is some retrenchment.
Leaks from the World Professional Association for Transgender Health, the body which formulates guidance on “trans healthcare”, reveal doctors perplexed at how they should explain to an 11-year-old child that drugs will render them infertile. Crucially, liberal media such as The New York Times are now reporting grave medical misgivings about child transition, once dismissed as a culture-war issue for the Republican right.
Yet the question remains: how was this ever allowed to happen? For years, puberty blockers were cheerily billed as a mere “pause button”. In 2014, Dr Polly Carmichael, the last head of Gids before the Cass review ordered its closure, went on CBBC in a show called I Am Leo, saying of blockers: “The good thing is, if you stop the injections, it’s like pressing ‘start’ and the body carries on developing as it would if you hadn’t started.”
The BBC permitted her to make this unevidenced claim to an impressionable audience of six to 12-year-olds. Imagine hearing this as a developing girl, freaked out by your new breasts and periods. No wonder Gids referrals subsequently rocketed.
Carmichael failed to mention that she did not know if pressing “restart” on puberty is always medically possible — it is not — and in fact, almost every child Gids put on blockers went on to irreversible cross-sex hormones.
After years in a Peter Pan state while their peers developed, they understandably felt there was no way back and forged on with treatment. Yet if allowed to experience natural puberty, almost 85 per cent of gender dysphoria cases resolve themselves.
Nor did Carmichael tell CBBC kids that the blockers-hormones combination, if taken early enough, not only results in sterility but kills the libido so that a young person will never experience an orgasm.
At the 2020 judicial review brought by a former Tavistock clinician and Keira Bell, the brave young detransitioner rushed onto hormones by Gids, judges expressed astonishment at Gids’s lack of an evidence base.
Reporting on this issue for seven years, I too have been struck by a complete clinical incuriosity. Not only was data not collected, but those who queried treatments or pressed for evidence faced angry condemnation. Perhaps activists knew what research might find because one long-term Finnish study, recently reported in the BMJ, destroyed the myth used to justify blockers: that a child will commit suicide if denied them.
The Finns found that “gender-affirming care” does not make a dysphoric child less suicidal. Rather, such children had the same suicide risk as others with severe psychiatric issues. In other words, changing bodies does not fix troubled minds.
Yet even after NHS England’s announcement, activists refuse to heed the now-overwhelming evidence. In its response, Stonewall persists with the myth that puberty blockers “give a young person extra time to evaluate their next steps”.
Many questions remain unanswered: will private clinics still be permitted to prescribe puberty blockers; and is Scotland’s Sandyford child gender clinic still determined to close its ears to all evidence? Plus, we have few details on how the NHS’s new “holistic” treatment for gender-questioning children will operate when it opens next month.
This repellent experiment — in which girls who like trucks or little boys who dress as princesses, and who invariably grow up to be gay, are corralled inexorably down a road towards life-changing treatments — belongs in the book of medical disgraces. As do the cheerleaders who raised money for Mermaids and those who persecuted whistleblowers or damned journalists asking questions as transphobic.
In 50 years, chemically freezing the puberty of healthy children with troubled minds will be regarded with the same horrified fascination as lobotomies — which, never forget, won the Portuguese neurologist Antonio Egas Moniz the 1949 Nobel prize.
--------------------
{Article source (behind paywall)}
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maddmann8128 · 10 months ago
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saintmeghanmarkle · 9 months ago
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I disagree with Sarah Vine's opinions on Harold in her latest DM piece: SARAH VINE: Happy 40th Harry. But has all the pain been for nothing? by u/Von_und_zu_
I disagree with Sarah Vine's opinions on Harold in her latest DM piece: SARAH VINE: Happy 40th Harry. But has all the pain been for nothing? Understandably, Harry is a wounded soul. [Nope. He has exceeded the Diana card limit in my opinion. He is not the only child ever to lose a parent.] But being in great pain [I think he is just a great jerk] does not confer the right to inflict the same on others – nor by doing so is your own suffering necessarily alleviated. [Harold's "suffering" is largely self inflicted. Choosing a bully for a wife. Choosing drugs as therapy. Being a self-absorbed spiteful bully himself. Etc.] Part of being a grown-up is realising this, and trying to end the cycle of unhappiness rather than perpetuate it. [Harold lives in a Never Neverland in his own mind. He never wants to grow up and take responsbility for anything.]Harry, though, has done the opposite. He has visited a terrible revenge on his father and the Queen, and turned on William and Kate for no obvious reason other than, perhaps, their decision to side with the King. [Um, hello. He is jealous of his brother and his wife. More sausages and all.]No wonder ­neither William nor Charles want to see him. In particular, Harry’s behaviour has been utterly toxic in light of the King and the Princess of Wales being treated for cancer. If he really is the kind, thoughtful soul his supporters claim, in his heart he must know this to be true. [Does he have a heart? I am uncertain.]And yet, while I despair of his methods and actions, part of me understands why he wanted to leave. [I do not think he intended to actually leave. He thought they would cave and beg him to come back on the terms he and his wife wanted because he and his wife are such hot stuff.] And though many sought to blame Meghan, I don’t believe it was ever really about her. It was about Harry and his damaged relationship with his family – and his desire to break his own generational curse. [Spare me the genetic pain. He is malevolent.] For that, I can’t help but grudgingly respect him. [R-E-S-P-E-C-T. That is not what it means to me.]It takes huge courage and determination to go against people’s expectations – and in Harry’s case, the nation’s. That he has done so is testament to his strength of character. [He has no strength or character in my opinion.] That he did it so viciously and so vindictively, though, is not.Should he be contemplating an ‘official’ return to the UK? [Shudder. No one wants him back.] I don’t think so. That would be a step backwards and mean all that pain was for nothing. [It would also mean he was wrong and he will never admit that to himself or anyone else. And what about his family's pain? ] He needs to find his own way forward. [Go to rehab Harold.] His decision not to update his autobiography, Spare, was a step in the right direction. [But was it a decision or a consequence of destroying all his materials?] But he’s got a long way to go to prove he has a new role to play without exploiting past capital. [He is still dining out on his family. He has nothing else to sell or offer.]Harry, I wish you the happiest of birthdays. May it mark the start of a new and more positive chapter in your life – and for all the royals. [Harold has his own chapter of joy?! How mindful! How demure!] Sarah - clue in! Harold is a loser! https://ift.tt/b4SZDmj post link: https://ift.tt/RktwY9f author: Von_und_zu_ submitted: September 15, 2024 at 05:13AM via SaintMeghanMarkle on Reddit disclaimer: all views + opinions expressed by the author of this post, as well as any comments and reblogs, are solely the author's own; they do not necessarily reflect the views of the administrator of this Tumblr blog. For entertainment only.
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pcrtisuyog · 1 month ago
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Why Clinical Research is the Backbone of Modern Healthcare
Have you ever wondered how a new medicine makes its way from a lab to your local pharmacy shelf? Or how do doctors decide which treatment is best for a particular disease? Behind the scenes, there’s a powerful, tireless engine driving these life-saving decisions — clinical research.
We often think of healthcare as what happens in hospitals and clinics — doctors diagnosing, nurses caring, and patients recovering. But the truth is, modern healthcare begins much earlier. It begins in research labs, with scientists, doctors, and volunteers working together to ask big questions and find real-world solutions. That’s why clinical research is the backbone of modern healthcare — it supports everything we trust, rely on, and hope for when it comes to healing and health.
What is clinical research?
Clinical research involves studying health and illness in people. It helps researchers understand diseases, develop treatments, and improve the overall quality of care. This research is carefully planned and carried out in phases to test:
Safety of new drugs or devices
Effectiveness of treatments
Better ways to detect, diagnose, or prevent diseases
Impact of lifestyle changes or behavior-based interventions
Every vaccine, medication, diagnostic method, and even surgical technique has undergone some form of clinical research before becoming standard care.
Real Lives, Real Impact
When we hear the term "clinical trial," we might imagine scientists in white coats and complex procedures. But at its core, clinical research is deeply human. It involves people from all walks of life — patients battling illnesses, carers seeking hope, and researchers committed to saving lives.
For example:
The development of the COVID-19 vaccines was made possible through unprecedented global collaboration in clinical trials.
Treatments for chronic diseases like diabetes, heart disease, and cancer have significantly improved thanks to years of dedicated clinical research.
Even rare genetic disorders are finding attention and solutions through targeted clinical studies.
Why Clinical Research Matters More Than Ever
As the world faces new health threats, growing populations, and evolving diseases, clinical research stands as our best defence. Here’s why clinical research is the backbone of modern healthcare:
1. Drives Innovation
Without research, medicine would stand still. New drug discoveries, personalised treatments, and innovative medical devices all start in clinical trials.
2. Ensures Patient Safety
Before any treatment reaches the public, it must pass rigorous testing for safety. Clinical research ensures that only safe and effective therapies make it to hospitals and pharmacies.
3. Supports Evidence-Based Medicine
Doctors rely on research data to make informed decisions. Clinical research provides the scientific foundation for modern treatment guidelines.
4. Empowers Patients
Participation in clinical trials gives patients access to cutting-edge treatments, often years before they become widely available.
5. Promotes Global Health
From malaria in Africa to cancer in the West, clinical research addresses health issues worldwide, saving millions of lives every year.
The Human Side of Clinical Research
One of the most overlooked aspects of clinical research is the bravery and generosity of the participants. These individuals volunteer, not just for their benefit, but for the good of society. They allow scientists to explore better ways to treat disease, manage symptoms, and improve life quality for future generations.
Let’s not forget the researchers and healthcare professionals who dedicate their careers to asking tough questions and finding answers. Their work doesn’t just sit in journals — it transforms lives.
Challenges and the Way Forward
Clinical research isn’t without its hurdles:
Long timelines and high costs
Recruitment and retention of trial participants
Ethical considerations and patient safety
Access disparities in underprivileged populations
But advancements in digital health, AI, remote monitoring, and decentralised trials are making research more inclusive, faster, and efficient.
Conclusion
When we talk about progress in healthcare, it’s easy to focus on what we can see — hospitals, medicines, and technology. But the real foundation lies in clinical research. It is the unseen but essential pillar that keeps healthcare moving forward, saving lives and improving health outcomes for millions.
So, the next time you hear about a new vaccine, a revolutionary cancer drug, or a promising treatment for Alzheimer’s, remember the incredible journey it took to get there — a journey powered by science, compassion, and the unwavering belief that we can do better.
That is why clinical research is the backbone of modern healthcare.
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insightful-scribbles · 2 months ago
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How is HIPEC Different from Traditional Chemotherapy?
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Cancer treatment has come a very long way. And if you or a loved one has been exploring options to battle it out, you might have come across HIPEC. One might wonder what exactly it is, and how it is different from traditional chemotherapy. Let’s break it down in a way that makes sense—absolutely no confusing medical jargon, just straight talk.
What is HIPEC, and How Does it Work?
HIPEC (Hyperthermic Intraperitoneal Chemotherapy) is a new generation game-changer option for patients dealing with abdominal cancers like peritoneal carcinomatosis, ovarian cancer, and some colorectal cancers. Notwithstanding the traditional chemotherapy that has been the usual mode of treatment, which circulates through your entire bloodstream, HIPEC delivers heated chemotherapy drugs directly into the abdomen after surgery. This means it targets cancer cells more aggressively without the harsh side effects of systemic chemo.
How is HIPEC Different from Traditional Chemotherapy?
If you've ever come across someone going through chemotherapy, you probably know how exhaustively draining it can be. Hair loss, nausea, and fatigue—it's tough. But HIPEC? It’s a whole new different approach.
Precision Targeting: Traditional chemotherapy flows through the bloodstream, which ends up affecting the entire body. But HIPEC, on the other hand, goes straight to the source—right where the cancer exists.
Higher Drug Concentration: Because the chemo is applied directly to the affected area, doctors can use much higher doses without harming the rest of your body.
Heat Boosts Effectiveness: HIPEC isn’t your normal regular chemo. It’s heated! The high temperature supports eliminating the cancer cells more effectively while making healthy cells more resistant.
Fewer Systemic Side Effects: Normally with traditional chemotherapy, your entire body takes a hit. While with HIPEC, the impact is mainly confined to the abdominal cavity, meaning fewer issues like hair loss and extreme fatigue.
Life Expectancy After HIPEC Surgery
One of the biggest questions people ask is, “Will this give me more time?”
While every patient’s journey is entirely different and cancer levels are varied, studies show that HIPEC can significantly improve survival rates compared to traditional chemotherapy for certain cancers. For example, patients suffering from peritoneal carcinomatosis who are treated with HIPEC have been reported to live years longer than those who opt for standard treatments. What is inspiring is that in some cases, HIPEC has even helped patients achieve long-term remission.
How Painful is HIPEC Surgery?
To be very honest—any major surgery comes with its share of discomfort. But how painful is HIPEC?
Since HIPEC is performed right after cytoreductive surgery (where doctors remove visible tumors), it’s a series of complex and intensive procedures. Recovery can take a few weeks, and some patients experience abdominal pain, bloating, or temporary digestive issues. The good news? Hospitals provide top-notch pain management to help you through the healing process, and most people find that the discomfort is manageable.
Is HIPEC Surgery Dangerous?
Any surgery carries risks, and HIPEC is no exception. But is it dangerous? Let’s put it this way—it’s a major procedure, but it’s performed by highly skilled specialists with years of supervised training, and who take every precaution to ensure safety.
Some possible complications include:
Infections (which can happen with any surgery)
Temporary bowel issues (since the abdomen is the focus of the treatment)
Fluid imbalances
However, most patients recover well with proper post-op care. Plus, the potential benefits—like longer survival and better quality of life—often outweigh the risks.
Best HIPEC Treatment in Ahmedabad
Now that you know about HIPEC. But if you are considering it, choosing the right medical team is crucial.
To receive the most effective HIPEC surgery in Ahmedabad, Dr. Aditi Bhatt is one of the expert surgical oncologists known for her specialization in HIPEC cancer surgery. Having a deep and broad knowledge about peritoneal cancers, ovarian cancer, and colorectal cancer, she is in a position to provide the most up-to-date, patient-oriented care with the help of advanced surgical techniques.
Her careful and thorough method of work promises better chances of survival, fewer side effects, and a better quality of life for the patients. In case you or your kin are giving serious thought to such a surgery, communicating with Dr. Aditi Bhatt might offer you the needed guidance in deciding the best suitable treatment alternatives as per your needs.
Diet After HIPEC Surgery
Diet After HIPEC Surgery plays a big role in recovery. After HIPEC, your digestive system needs time to adjust. As such, you’ll start with easy-to-digest simple foods and gradually you can reintroduce more variety.
What should you eat?
First few days: Clear liquids like broths and herbal teas would be ideal.
After a week: Soft foods like mashed potatoes, yogurt, and well-cooked vegetables.
Long-term: A balanced diet with lean proteins, whole grains, and plenty of fluids to keep your body strong.
One tip? Small, frequent meals work better than big ones. Your body will thank you for it!
Final Thoughts
HIPEC isn’t just another cancer treatment—it’s a powerful alternative for patients who need a targeted, high-impact approach. While it’s more invasive than traditional chemotherapy, it offers longer survival, fewer systemic side effects, and a better quality of life for many patients.
If you or a loved one is considering HIPEC, talk to an experienced specialist, weigh the risks and benefits, and make an informed decision. Because when it comes to fighting cancer, the right treatment can make all the difference.
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pk1997digikit · 2 months ago
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Why Participate in Dermatology Clinical Studies? Benefits and Insights
Advancements in dermatology have transformed the way we diagnose and treat skin conditions, thanks to the invaluable role of clinical research. Clinical studies in dermatology provide a pathway to discovering innovative treatments, refining existing therapies, and understanding skin diseases at a deeper level. These studies not only benefit the medical community but also offer participants a unique opportunity to access cutting-edge treatments before they become widely available. At Cutis Clinical Research, we are committed to pioneering research that drives meaningful progress in dermatological care.
What Are Dermatology Clinical Studies?
Clinical studies, also known as clinical trials, are research investigations that evaluate new medical treatments, drugs, or procedures to determine their effectiveness and safety. These studies follow a rigorous scientific process, ensuring that all treatments undergo thorough testing before being introduced to the general public.
In clinical studies in dermatology, researchers focus on skin diseases such as psoriasis, eczema, acne, skin cancer, and rare dermatological disorders. These studies may involve:
New drug formulations and topical treatments
Advanced laser and light therapies
Novel biologic and immunotherapy treatments
Cutting-edge diagnostic tools and screening techniques
Investigations into the role of genetics and microbiome in skin health
Benefits of Participating in Dermatology Clinical Studies
Many individuals wonder why they should consider participating in clinical research. Here are some compelling reasons why dermatology clinical studies can be beneficial:
1. Access to Innovative Treatments Before Public Availability
One of the most significant benefits of joining a clinical study is the opportunity to receive breakthrough treatments before they become commercially available. Participants may gain access to new therapies that are more effective, have fewer side effects, or offer improved convenience compared to existing treatments.
2. Expert Medical Care and Monitoring
Patients in clinical studies are closely monitored by dermatology experts and medical researchers. This means participants receive specialized medical attention throughout the trial, ensuring that their condition is carefully observed, managed, and documented.
3. Contribution to Medical Science and Patient Care
By participating in a clinical study, individuals play an essential role in advancing dermatological research. Their involvement helps researchers develop better treatments and improve care for future patients suffering from similar skin conditions.
4. Potential Cost Savings
Many clinical studies provide participants with free access to investigational treatments, medical tests, and regular health check-ups. In some cases, compensation may also be provided for time and travel expenses.
5. Improved Understanding of Personal Skin Health
Patients often gain valuable insights into their skin condition through clinical research participation. The thorough medical evaluations and testing performed during trials can help individuals better understand their dermatological concerns and potential treatment options.
Understanding the Clinical Study Process
Before enrolling in a dermatology clinical study, it is essential to understand how these trials work. Clinical trials are conducted in several phases:
Phase 1: Tests a new treatment on a small group of healthy volunteers or patients to assess safety and dosage.
Phase 2: Expands testing to a larger group of individuals with the specific skin condition to determine effectiveness and side effects.
Phase 3: Compares the new treatment with existing therapies to confirm its effectiveness and monitor adverse reactions.
Phase 4: Conducted after regulatory approval, this phase continues to track long-term benefits and potential risks in a broader population.
Who Can Participate in a Dermatology Clinical Study?
Each clinical trial has specific eligibility criteria, which may include:
Age and gender requirements
Type and severity of the skin condition
Medical history and overall health status
Previous treatments tried for the condition
Before enrolling, participants will undergo a screening process to ensure they meet the study's criteria. It is also important for patients to discuss participation with their healthcare provider to determine if the study aligns with their medical needs.
Addressing Common Concerns About Clinical Studies
Many people hesitate to participate in clinical trials due to concerns about safety, risks, and the experimental nature of treatments. However, all clinical studies are governed by strict ethical and regulatory guidelines to ensure patient safety.
Are clinical studies safe?
Yes, they are carefully regulated and conducted under the supervision of medical professionals.
Will I receive a placebo instead of actual treatment?
Some trials include a placebo group, but participants are always informed of the study design before enrollment.
Can I withdraw from a study if I change my mind?
Yes, participation is entirely voluntary, and individuals can leave a study at any time without consequences.
Conclusion
Dermatology clinical studies play a vital role in shaping the future of skin health by introducing new treatments and improving existing ones. Participating in a clinical trial not only provides access to advanced therapies and expert care but also contributes to the broader medical community's knowledge.
At Cutis Clinical Research, we are dedicated to conducting ethical and impactful clinical studies in dermatology, helping to drive medical progress and improve patient outcomes. If you are interested in learning more about ongoing dermatology clinical studies or exploring participation opportunities, we invite you to connect with us today.
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maddmman2 · 5 months ago
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prpinjections · 3 months ago
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Are PRP Injections Right for You? A Complete Guide to Candidacy and Benefits
In the world of regenerative medicine, few treatments have gained as much attention — and delivered as many promising results — as PRP Injections. From healing injuries and restoring youthful skin to enhancing sexual wellness, Platelet-Rich Plasma (PRP) therapy offers a natural, non-surgical solution for people looking to revitalize their health. But is PRP the right option for you?
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If you’ve been considering PRP Injections - Bio Restore, or wondering how PRP compares to treatments like Testosterone Replacement Therapy and Stem Cell Therapy, this guide is for you. We’ll break down how PRP works, its many applications, and who makes an ideal candidate for this revolutionary treatment.
Let’s explore the science behind PRP and help you decide if it’s the solution your body has been craving.
What Are PRP Injections?
Platelet-Rich Plasma (PRP) is a regenerative therapy that harnesses the body’s natural healing abilities. The process is simple:
Blood Draw: A small sample of your blood is drawn.
Centrifuge Processing: The blood is spun in a centrifuge to separate the platelets from other components.
Injection: The concentrated platelet-rich plasma, filled with powerful growth factors, is injected into the targeted area.
These growth factors stimulate cell repair, tissue regeneration, and new blood vessel formation — making PRP a powerful tool for healing and restoration.
What Can PRP Treat?
PRP is incredibly versatile. Its regenerative properties make it effective for a wide range of health and wellness concerns, including:
Joint and Soft Tissue Injuries: PRP accelerates healing for tendonitis, ligament injuries, arthritis, and more.
Sexual Wellness: PRP can improve blood flow, sensitivity, and performance for both men and women.
Skin Rejuvenation: PRP helps reduce fine lines, wrinkles, and scarring by promoting collagen production.
Hair Restoration: PRP stimulates hair follicles, encouraging thicker, healthier hair growth.
Chronic Pain Management: PRP reduces inflammation and supports long-term pain relief.
When combined with treatments like Stem Cell Therapy and Testosterone Replacement Therapy, PRP becomes even more powerful — addressing the root causes of health concerns and promoting comprehensive healing.
Who Is a Good Candidate for PRP Injections?
PRP is safe, minimally invasive, and suitable for many people. However, it tends to be most effective for individuals who:
Have Chronic Pain or Slow-Healing Injuries: If you’re dealing with lingering joint pain or sports injuries, PRP can help your body complete the healing process.
Want to Avoid Surgery: PRP is a non-surgical option that may reduce or eliminate the need for invasive procedures.
Struggle with Sexual Dysfunction or Low Libido: PRP enhances blood flow and tissue sensitivity, which can significantly improve intimate health.
Experience Age-Related Health Declines: From thinning hair to joint pain, PRP helps combat the natural wear and tear of aging.
Are Seeking Natural, Drug-Free Solutions: Because PRP comes from your own blood, it’s a natural alternative to pharmaceuticals.
If you’re already exploring other regenerative treatments — like Testosterone Replacement Therapy for hormone balance or Stem Cell Therapy for more advanced tissue regeneration — PRP can enhance and accelerate your results.
Who Should Avoid PRP Therapy?
While PRP is safe for most people, there are a few exceptions. You may not be a good candidate if you:
Have a bleeding disorder or take blood thinners
Have an active infection at the injection site
Are dealing with severe, advanced joint degeneration (in which case surgery may be necessary)
Have certain cancers or systemic health conditions
That said, many people who initially think they’re not candidates can still benefit from PRP when paired with complementary therapies. For example, someone with severe arthritis may benefit from combining PRP Injections - Bio Restore with Stem Cell Therapy to enhance tissue repair more comprehensively.
What to Expect During and After PRP Treatment
One of the biggest perks of PRP therapy is how straightforward the treatment process is. Most appointments take less than an hour, and you can return to normal activities almost immediately.
After the injection, you might experience mild soreness or swelling, but this usually subsides within a few days. The healing process continues beneath the surface, with most people noticing gradual improvements over several weeks.
Depending on your condition and goals, multiple PRP sessions may be recommended. For example, someone using PRP for hair restoration might need 3-4 treatments spaced a few weeks apart, while someone using PRP for joint pain might experience relief after just one session.
Why Combine PRP with Other Regenerative Treatments?
PRP is powerful on its own, but when combined with other regenerative therapies, the results can be life-changing.
Testosterone Replacement Therapy (TRT): For men dealing with fatigue, low libido, or poor recovery, TRT can optimize hormone levels while PRP repairs tissues. Together, they help restore energy, vitality, and performance.
Stem Cell Therapy: Stem cells have a remarkable ability to transform into different cell types, accelerating tissue regeneration. When used with PRP, they amplify the healing process, especially for chronic pain or injury recovery.
IV Therapy: Nutritional IV infusions provide the body with the vitamins, minerals, and hydration it needs to support cellular health — further enhancing PRP’s regenerative effects.
This combination approach allows patients to address multiple aspects of health simultaneously, creating faster, more comprehensive results.
Is PRP the Missing Piece of Your Health Puzzle?
If you’ve been struggling with pain, declining energy, or intimate health issues, PRP could be the natural, effective solution you’ve been searching for. It’s safe, minimally invasive, and backed by science—with countless success stories from people who’ve experienced life-changing results, including improved recovery, enhanced vitality, and support for body sculpting.
At Bio Restore, we specialize in personalized regenerative medicine, crafting treatment plans that blend PRP Injections, Testosterone Replacement Therapy, Stem Cell Therapy, and IV Therapy to help you achieve optimal wellness. Our expert team is here to guide you, answer your questions, and create a path to healing that’s tailored to your unique needs.
Why wait to feel better when your body already has the tools to heal itself? Let PRP unlock your natural potential — and help you live a healthier, more vibrant life.
PRP Injections - Bio Restore 32 Church Hill Rd Unit E, Newtown, CT 06470, United States 1-203-463-5765 https://biorestorehealth.com/prpinjections
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sunaleisocial · 3 months ago
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A protein from tiny tardigrades may help cancer patients tolerate radiation therapy
New Post has been published on https://sunalei.org/news/a-protein-from-tiny-tardigrades-may-help-cancer-patients-tolerate-radiation-therapy/
A protein from tiny tardigrades may help cancer patients tolerate radiation therapy
About 60 percent of all cancer patients in the United States receive radiation therapy as part of their treatment. However, this radiation can have severe side effects that often end up being too difficult for patients to tolerate.
Drawing inspiration from a tiny organism that can withstand huge amounts of radiation, researchers at MIT, Brigham and Women’s Hospital, and the University of Iowa have developed a new strategy that may protect patients from this kind of damage. Their approach makes use of a protein from tardigrades, often also called “water bears,” which are usually less than a millimeter in length.
When the researchers injected messenger RNA encoding this protein into mice, they found that it generated enough protein to protect cells’ DNA from radiation-induced damage. If developed for use in humans, this approach could benefit many cancer patients, the researchers say.
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“Radiation can be very helpful for many tumors, but we also recognize that the side effects can be limiting. There’s an unmet need with respect to helping patients mitigate the risk of damaging adjacent tissue,” says Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital.
Traverso and James Byrne, an assistant professor of radiation oncology at the University of Iowa, are the senior authors of the study, which appears today in Nature Biomedical Engineering. The paper’s lead authors are Ameya Kirtane, an instructor in medicine at Harvard Medical School and a visiting scientist at MIT’s Koch Institute for Integrative Cancer Research, and Jianling Bi, a research scientist at the University of Iowa.
Extreme survival
Radiation is often used to treat cancers of the head and neck, where it can damage the mouth or throat, making it very painful to eat or drink. It is also commonly used for gastrointestinal cancers, which can lead to rectal bleeding. Many patients end up delaying treatments or stopping them altogether.
“This affects a huge number of patients, and it can manifest as something as simple as mouth sores, which can limit a person’s ability to eat because it’s so painful, to requiring hospitalization because people are suffering so terribly from the pain, weight loss, or bleeding. It can be pretty dangerous, and it’s something that we really wanted to try and address,” Byrne says.
Currently, there are very few ways to prevent radiation damage in cancer patients. There are a handful of drugs that can be given to try to reduce the damage, and for prostate cancer patients, a hydrogel can be used to create a physical barrier between the prostate and the rectum during radiation treatment.
For several years, Traverso and Byrne have been working on developing new ways to prevent radiation damage. In the new study, they were inspired by the extraordinary survival ability of tardigrades. Found all over the world, usually in aquatic environments, these organisms are well known for their resilience to extreme conditions. Scientists have even sent them into space, where they were shown to survive extreme dehydration and cosmic radiation.
One key component of tardigrades’ defense systems is a unique damage suppressor protein called Dsup, which binds to DNA and helps protect it from radiation-induced damage. This protein plays a major role in tardigrades’ ability to survive radiation doses 2,000 to 3,000 times higher than what a human being can tolerate.
When brainstorming ideas for novel ways to protect cancer patients from radiation, the researchers wondered if they might be able to deliver messenger RNA encoding Dsup to patient tissues before radiation treatment. This mRNA would trigger cells to transiently express the protein, protecting DNA during the treatment. After a few hours, the mRNA and protein would disappear.
For this to work, the researchers needed a way to deliver mRNA that would generate large amounts of protein in the target tissues. They screened libraries of delivery particles containing both polymer and lipid components, which have been used separately to achieve efficient mRNA delivery. From these screens, they identified one polymer-lipid particle that was best-suited for delivery to the colon, and another that was optimized to deliver mRNA to mouth tissue.
“We thought that perhaps by combining these two systems — polymers and lipids — we may be able to get the best of both worlds and get highly potent RNA delivery. And that’s essentially what we saw,” Kirtane says. “One of the strengths of our approach is that we are using a messenger RNA, which just temporarily expresses the protein, so it’s considered far safer than something like DNA, which may be incorporated into the cells’ genome.”
Protection from radiation
After showing that these particles could successfully deliver mRNA to cells grown in the lab, the researchers tested whether this approach could effectively protect tissue from radiation in a mouse model.
They injected the particles into either the cheek or the rectum several hours before giving a dose of radiation similar to what cancer patients would receive. In these mice, the researchers saw a 50 percent reduction in the amount of double-stranded DNA breaks caused by radiation.
“This study shows great promise and is a really novel idea leveraging natural mechanisms of protection again DNA damage for the purpose of protecting healthy cells during radiation treatments for cancer,” says Ben Ho Park, director of the Vanderbilt-Ingram Cancer Center at Vanderbilt University Medical Center, who was not involved in the study.
The researchers also showed that the protective effect of the Dsup protein did not spread beyond the injection site, which is important because they don’t want to protect the tumor itself from the effects of radiation. To make this treatment more feasible for potential use in humans, the researchers now plan to work on developing a version of the Dsup protein that would not provoke an immune response, as the original tardigrade protein likely would.
If developed for use in humans, this protein could also potentially be used to protect against DNA damage caused by chemotherapy drugs, the researchers say. Another possible application would be to help prevent radiation damage in astronauts in space.
Other authors of the paper include Netra Rajesh, Chaoyang Tang, Miguel Jimenez, Emily Witt, Megan McGovern, Arielle Cafi, Samual Hatfield, Lauren Rosenstock, Sarah Becker, Nicole Machado, Veena Venkatachalam, Dylan Freitas, Xisha Huang, Alvin Chan, Aaron Lopes, Hyunjoon Kim, Nayoon Kim, Joy Collins, Michelle Howard, Srija Manchkanti, and Theodore Hong.
The research was funded by the Prostate Cancer Foundation Young Investigator Award, the U.S. Department of Defense Prostate Cancer Program Early Investigator Award, a Hope Funds for Cancer Research Fellowship, the American Cancer Society, the National Cancer Institute, MIT’s Department of Mechanical Engineering, and the U.S. Advanced Research Projects Agency for Health. 
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