#multichannel pipette

[friendofcars]

today was lovely if only because I got to use the multichannel pipette

[pakgent]

PakGent 1000ul Standard Low Retention Pipette Tips

These 1000 ul multichannel pipette tips are designed for use in molecular biology and biotechnology laboratories. They are made from outstanding polypropylene, making these 1000ul multichannel pipette tips compatible with a wide range of pipettes and other lab equipment. The 1000ul multichannel pipette tips feature an ergonomic design for comfortable grip and easy handling.

1000ul Standard Low Retention Pipette Tips FAQs

01

What Is the Volume Capacity of the 1000ul Standard Low Retention Pipette Tips?

The 1000ul Standard Low Retention Pipette Tips are designed to hold up to 1000 microliters or 1 milliliter of liquid.

02

Can These Pipette Tips Be Used with All Types of Pipettes?

Generally, these pipette tips are compatible with most pipettes that have a standard tip fitting size. However, it is always recommended to check tip compatibility with your specific pipette model before purchasing.

03

Can These Pipette Tips Be Reused?

No, pipette tips are designed for single-use only. Reusing pipette tips can lead to inaccurate results and compromise experimental integrity.

04

Can These Pipette Tips Be Autoclaved?

Yes, most pipette tips can be autoclaved for sterilization. However, it is important to follow the manufacturer's recommended autoclave settings to avoid damaging the tips.

Applications and Uses of 1000ul Multichannel Pipette Tips in Molecular Biology and Biotechnology

The 1000ul multichannel pipette tips are essential in molecular biology and biotechnology. They accurately dispense reagents in PCR and qPCR, facilitate DNA/RNA extraction and cell culture, optimize gene expression analysis, and improve NGS workflows. These tips are also vital for HTS, protein purification, ELISA assays, and sample storage. Their versatility and reliability make them indispensable tools for researchers and scientists using 1000ul multichannel pipettes in various applications.

Advantages of 1000ul Multichannel Pipette Tips: The Ultimate Multichannel Pipette Universal Tips

The 1000ul Multichannel Pipette Tips surpass other brands in multiple ways, making them the optimal choice for laboratory and research facilities.

Superior Quality: Made from premium materials, these tips ensure durability, longevity, and a tight seal that prevents leakage. They resist cracking, minimizing the risk of contamination during experiments.

Enhanced Compatibility: Specifically designed to fit most multichannel pipette tips, these tips serve as universal tips. This eliminates the need for multiple tip attachments, saving both time and resources, regardless of the pipette brand.

Wide Range of Applications: These versatile 1000ul sterile pipette tips excel in various research fields, effortlessly handling tasks ranging from molecular biology to biochemistry. With their robust design, precise liquid dispensing is achievable, enabling high-throughput experiments and large-scale sample handling.

[that-pipette-girl]

I hate doing Bradford Assays

Legit about to be sobbing, crying, throwing up because this fucking TIME-SENSITIVE assay keeps screwing me up!! Linear regression won't cooperate and I am this close to just losing it. It's supposed to be a simple assay but for some reason, I am completely incompetent at it to extreme levels. I am so, so angry. I'm not sure to myself or my PI. But I am so mf-ing pissed off. I have a meeting with him tomorrow at 10:30 AM, AND I HAVE NOTHING TO SHOW HIM. FUCK.

He's already disappointed in me; it's no big deal except for the fact that I lowkey hate my research now. I can't freaking progress in my project now because I can't do this assay, and it is literally hurting my soul.

I think I may have died and been sent to hell because this assay is my Sisyphean task for weeks on end. Good fucking Lord. I am literally so internally done with it all.

[geneticcatalyst]

Top 5 pieces of lab equipment

Centrifuge. Classic but also essential. Separates your shit with the power of physics aka tell them to get rotated at 5000 rpm, idiots. Comforting hum and sometimes warm air when nicely balanced. Do Not poorly balance your centrifuges around me, I respond to it like nails on a chalkboard that's also abusing a puppy.

Vortexer. Does the opposite of the centrifuge. Literally stimulation go brrrr. Satisfying in a way that's hard to explain if you haven't used one- press test tube on grippy platform, it shakes real good, your shit is now unseparated.

Micropipetter. THE GOOD ONES ie the one pictured below, which is the Gilson Pipetman Classic (tm). I have a powerful bias for these because they're what I had in my very first lab job and the feel of them is just. Better than any of the newer and cheaper ones I've used. If you're pro level you can even main the 8 or 12 channel but Be Careful. I am of course pro level, I LEARNED to pipette loading electrophoresis gels with a multichannel and to this day nothing else has required that level of pipette finesse. You can buy your own single channel Pipetman Classic on Fisher Scientific's website for just $732 ❤

Spectrophotometer/fluorometer. Similar and sometimes combined into one piece of equipment although there are many kinds. Tells you what's in your shit. This is important because, at last in my line of work, the stuff your lab is both paying and being paid big money for all looks like clear water. Because it's very small and suspended in clear water. Is your shit actually in there and how much/what kind is a very important question to know if all your other shit is working. Also in the case of fluorescence generates the data that is what you're actually getting paid for, essentially also answering the question of What's In Your Shit.

Sharpie. Beat out the rest of the competition for its ubiquitousness. You're doing lab work? You need a sharpie. You gotta label a glass beaker with the date your media was made? You gotta label a stack of plastic plates going in the -80 freezer? You gotta write a post it note saying DONT TOUCH TEST IN PROCESS? You gotta draw a diagram of how polymerase chain reaction works on a paper towel for the new kid? You need to write a reminder to yourself to take yesterday's samples out of the incubator at exactly 1:07 on your arm? Sharpie.

[accumax]

Different Types of Pipette Tips and When to Use Them

Like deciding what to wear for the day, walking into a laboratory means you have to choose the right pipette tips for your experiments. This is about precision in avoiding mistakes and contamination rather than personal preferences when working in a lab. There are various types of tips, each designed with a specific application in mind.

Below is an ultimate guide on how to make sense of different kinds of pipette tips and their uses.

1. Non-Sterile vs. Sterile Tips

Non-Sterile Tips: These can be used for general laboratory procedures where sterility is not necessary. Using non-sterile tips may save money if you are dealing with non-sensitive samples or performing routine tasks.

Sterile Tips:

Required when doing tests where contamination would lead to compromised results, such as in microbiology, molecular biology or clinical settings. Such tips are pre-sterilized and certified free from contaminants like RNase, DNase, endotoxins etc. Although it might seem appealing to autoclave non-sterile tips onto sterile ones, inconsistent outcomes may occur because autoclaving does not have quality control measures.

2. Filter Tips

Filter Tips They are designed in such a way that prevents aerosols and liquids from entering the pipette body and thus safeguarding your samples as well as the pipette. Whenever you are dealing with volatile substances, corrosives or infectious materials it is important to use them. In some cases like PCR experiments where there is risk of contamination leading to false results, presence of filter tips is compulsory.

3. Long Tips

Long tips can get to the bottom of narrow tubes and deepwell plates without causing contamination towards the pipette’s shaft. In case you are working in a laboratory where you transfer liquids from tall containers, it is advisable to use long tips that maintain sterility and accuracy.

4. Short Tips

If you have short tips, ergonomic pipetting will be made possible, and hence there will be less strain on your arm or hand especially if you are using small well plates or multichannel pipettes. By sitting closer to the bench, they ensure exact pipetting making them the best for such fast robots.

5. Low Retention Tips

Low retention tips refer to those that comprise of special polypropylene blend or else coated with a hydrophobic surface intended for minimizing liquid retention. It is particularly essential when handling viscous or low surface tension liquids like concentrated protein or DNA solutions; this kind of tips ensures maximum sample recovery as well as accurate pipetting which may influence sensitive assays.

6. Wide Bore Tips

In delicate specimens like cell suspensions, standard ones can shear cells mainly due to their small opening; while wide bore tips have bigger holes thus providing easy passage for the solution through them hence preventing damage among other things when dealing with delicate samples such as cells in suspension or very thick liquids.

What Counts Concerning Quality and Fit

Quality of the tips that you get is as important as choosing the right type of tip for your pipette. This is because, by selecting poorly fitting or low quality tips, you risk taking inaccurate measures, adding to the strain of pipetting and contaminating samples in the process. Thus, it is advised that a high-quality tip should be compatible with your pipette for better outcomes and accurate results. Keep in mind therefore, how well the tips fit into your pipette so as to ensure consistency in lab work.

The importance of selecting the correct pipette tip does not depend on someone’s liking but rather impacts on getting reliable results. In order to ensure successful and efficient lab work it is necessary to identify various types of pipette tips and their applications. This blog originally posted here:  Different Types of Pipette Tips and When to Use Them

[healthcarehubhh]

Laboratory Equipment: Essential Tools for Research and Development

Microscopes are indispensable tools for laboratories as they enable researchers to see structures and features too small for the naked eye. Different types of microscopes like compound, stereo, and electron microscopes allow examination of cells, tissues and various samples at different levels of magnification. Compound microscopes have interchangeable objectives and ocular lenses that provide low to high magnifications from 40X to 1000X. Stereo microscopes give low magnifications from 6X to 120X and are ideal for viewing three-dimensional samples. Electron microscopes have resolutions down to the nanometer level and are crucial for cellular and molecular analysis. Microscopes continue advancing with techniques like fluorescence and confocal microscopy for live cell imaging. Laboratory Equipment: Pipettes and Dispensers Handling small liquid volumes accurately is critical in many experimental procedures. Pipettes available in various fixed and adjustable volumes are used to transfer samples, reagents, drugs and more between tubes, plates or vessels. Manual pipettes come in single channel and multichannel varieties for quickly dispensing set volumes. Electronic pipettes automate repetitive pipetting with adjustable speed and greater reproducibility. Dispensers are also available for liquid handling, dispensing adhesive liquids, organic solvents and even highly viscous materials. Automated liquid handlers are large capital equipment that can pipette thousands of samples in parallel for high throughput experiments. Centrifuges Centrifugation is a fundamental separation technique used across all types of laboratories. Benchtop centrifuges are simple bi-phasic models suitable for routine pelleting of cells, small particles and precipitates. They provide RCFs (relative centrifugal forces) from 1000 to 12000g. Preparative centrifuges have larger rotors and capacities for voluminous sample processing. Ultracentrifuges enable high speed sedimentation by developing enormous RCFs over 100,000g. Models for ultracentrifugation employ zonal, swinging bucket or fixed angle rotors depending on the separation goals. Selecting the right centrifuge based on sample type, size and desired separations is key for optimizing results. Laboratory Equipment: Spectrophotometers and Colorimeters Quantifying analytes through detection and measurement of light absorbance or transmittance is done using spectrophotometers and colorimeters. They are indispensable in analytical chemistry, biochemistry and molecular biology labs. Single beam spectrophotometers detect absorbance of a sample against a blank reference. Double or triple beam instruments allow simultaneous measurement of multiple samples and references. Colorimeters are compact single wavelength devices ideal for dedicated absorbance assays. Modern multi-mode readers combine varied features like fluorescence, luminescence, absorbance in a single box for versatility. Automated instruments speed up high throughput absorbance measurements in microplates. Advancements in detector and optic materials continue enhancing sensitivity and accuracy. Laboratory Equipment: Water Purification Systems Pure water is imperative for numerous analytical procedures and as a solvent in chemical reactions. Laboratories install point-of-use or centralized water purification systems to generate different grades of water for their needs. Reverse osmosis systems yield high purity water from tap or well sources. Ion exchange columns further polish RO water to Type I standards. Advanced systems integrate UV oxidation to minimize microbial growth and sub-micron filtration for generating ultra pure or Milli-Q water. Water qualities are certified through resistivity, TOC and particle testing. Laboratories also require simple dispensers of purified water right at the bench. Mobile cart-based purifiers deliver purified water anywhere as needed. Integrated systems optimize space and centralize management of water purification.

[labequipmentindia]

 Lab Equipment

1. Beakers and Flasks: Foundations of Measurement

Beakers and flasks are iconic symbols of laboratory Equipment work, serving as vessels for holding, mixing, and measuring liquids. Beakers come in various sizes, typically marked with volume gradations for accurate measurement. They are versatile, allowing scientists to perform tasks such as stirring, heating, and pouring. Flasks, on the other hand, often have narrower necks and are used for more precise measurements and reactions where evaporation needs to be minimised. Together, these basic containers form the backbone of liquid handling in labs worldwide.

2. Microscopes: Unlocking the Microcosm

Microscopes are indispensable lab equipment tools for exploring the microscopic world. They enable scientists to magnify objects hundreds or even thousands of times, revealing details that are invisible to the naked eye. From examining cells and microorganisms to analyzing materials at the nanoscale, microscopes play a crucial role in fields such as biology, medicine, materials science, and beyond. With advancements like electron microscopy and confocal microscopy, researchers can delve even deeper into the intricacies of the microcosm.

3. Centrifuges: Separating Powerhouses

Centrifuges harness the principles of centrifugal force to separate substances based on their density. By spinning samples at high speeds, centrifuges cause heavier particles to settle at the bottom while lighter components rise to the top. This process is invaluable for tasks such as isolating DNA, purifying proteins, and separating blood components in medical diagnostics. Modern centrifuges offer a range of capabilities, including variable speed settings, temperature control, and specialized rotors for specific applications.

4. Spectrophotometers: Shedding Light on Chemical Analysis

lab equipment Spectrophotometers are instrumental in quantifying the amount of light absorbed or transmitted by a substance across different wavelengths. This information is used to determine the concentration of analytes in solutions, making spectrophotometry a cornerstone technique in fields like biochemistry, environmental science, and pharmaceuticals. UV-visible spectrophotometers are commonly used for measuring organic compounds, while infrared and atomic absorption spectrophotometers cater to different analytical needs.

5. Incubators and Ovens: Cultivating Conditions

lab equipment and ovens provide controlled environments for cultivating cells, growing cultures, and conducting experiments that require specific temperature and humidity conditions. Incubators are crucial for cell culture work, microbiology research, and molecular biology techniques like PCR (polymerase chain reaction). Ovens, on the other hand, are used for sterilization, drying, and heat treatments in applications ranging from sample preparation to materials testing.

6. Pipettes and Dispensers: Precise Liquid Handling

Pipettes and dispensers are precision instruments used for transferring precise volumes of liquids. Manual pipettes are operated by hand and are available in various formats, including micropipettes for small volumes and multichannel pipettes for high-throughput applications. Automated pipetting systems offer increased efficiency and reproducibility, making them ideal for tasks like serial dilutions, liquid handling in high-throughput screening, and molecular biology workflows.

7. Analytical Balances: Weighing with Precision

Analytical balances provide accurate measurements of mass, essential for tasks like preparing solutions, dosing reagents, and determining the purity of substances. These balances offer high precision, often capable of measuring weights down to the microgram or even nanogram level. They are equipped with features such as draft shields to minimize environmental interference and calibration routines to ensure accuracy.

lab equipment, the workhorses of any laboratory. Beakers, test tubes, and flasks, made from durable glass, are used for mixing, storing, and heating various substances. Pipettes, with their precise markings, ensure accurate measurements of even the smallest volumes. And who can forget the ubiquitous Bunsen burner, providing heat for countless experiments?

Delving deeper:

As we move beyond the basics, we encounter a world of specialized equipment. Microscopes, with their powerful lenses, unveil the unseen world of cells and microorganisms. Centrifuges separate mixtures based on density, while spectrometers analyze the composition of materials. Each piece of equipment is designed for a specific purpose, contributing to the scientific process in its own unique way.

The cutting edge:

Modern science is constantly evolving, and so is the equipment that supports it. Advanced tools like 3D printers and gene sequencers are pushing the boundaries of what’s possible. These sophisticated instruments allow scientists to create complex structures, analyze DNA, and unlock the secrets of life itself.

Beyond the tools:

But lab equipment is more than just tools. They are partners in discovery, silent witnesses to countless experiments and breakthroughs. They represent the dedication and ingenuity of scientists, engineers, and technicians who design, build, and use these instruments to push the frontiers of knowledge.

[biomedpostgradlad]

"Dearly Beloved" no that's whoever invented the multichannel pipette.

[stonylabchem]

STONYLAB 8-Channel Pipettor Controller

50 to 300 ul

Sold only for $225.39

Featuring ergonomic design and intuitive operating concept, StonyLab 8 Channels Pipettor is ideal to handle multiple samples simultaneously with high accuracy and efficiency

Volume range: 50 to 300 uL; Volume setting is continuously adjustable by turning thumb wheel with a clear volume indicator; minimum increment per single adjustment: 5 uL

Tip cone is autoclavable and can be steam sterilized at 121℃ for up to 20 minutes

Easy to recalibration if needed; Included color caps for conveniently mark different uses of pipettes in lab

Discover more at

💡A multi-channel pipettor, also known as a multi-channel pipette or multi-pipette, is a laboratory instrument used for accurately and efficiently dispensing small volumes of liquid into multiple containers simultaneously. It is commonly used in chemistry and molecular biology labs for tasks such as sample preparation, DNA sequencing, PCR (Polymerase Chain Reaction), and ELISA (Enzyme-Linked Immunosorbent Assay), among others. Multi-channel pipettors come in various configurations, typically with 8, 12, or 16 channels, allowing you to handle multiple samples at once.

[microlitseo]

Liquid Handling Instruments for Bioprocessing: An Overview

Bioprocessing is a cornerstone of modern biotechnology, encompassing the production of pharmaceuticals, vaccines, enzymes, and other biologically derived products. At the heart of this sophisticated process lies the precise handling of liquids—whether it’s the transfer of cell cultures, media, or reagents. Liquid handling instruments play a vital role in ensuring accuracy, sterility, and efficiency in bioprocessing workflows. Here's an overview of the essential liquid handling instruments used in the field.

1. Pipettes and Pipetting Systems

Pipettes are indispensable tools for transferring small volumes of liquid with precision. Manual and electronic pipettes are commonly used in bioprocessing laboratories, offering accuracy for tasks like media preparation and sample addition. Advanced pipetting systems, including multichannel and robotic pipettes, enhance throughput and consistency in repetitive tasks, such as high-throughput screening or assay setups.

2. Peristaltic Pumps

Peristaltic pumps are highly valued in bioprocessing for their ability to handle delicate fluids without contamination. These pumps work by compressing flexible tubing to create a wave-like motion, allowing liquid transfer without direct contact with pump components. Ideal for aseptic operations, peristaltic pumps are frequently used for transferring culture media, buffers, or even cell suspensions in both upstream and downstream processes.

3. Bioprocess Controllers

Integrated liquid handling systems often feature bioprocess controllers that manage multiple aspects of liquid flow, including pH, dissolved oxygen, and nutrient feeding. These controllers ensure the precise addition of liquids during fermentation or cell culture processes, enabling consistent growth conditions and product yield.

4. Microplate Dispensers

In applications like vaccine development and monoclonal antibody production, microplate dispensers are vital for dispensing precise liquid volumes into 96- or 384-well plates. These automated instruments improve the speed and accuracy of filling, reducing the risk of cross-contamination and human error in high-throughput workflows.

5. Syringe Pumps

Syringe pumps are used for ultra-precise delivery of liquids, particularly in small-scale bioprocessing or research applications. These pumps are ideal for dispensing reagents, injecting samples into analytical instruments, or feeding nutrients into small bioreactors.

6. Automated Pipetting Robots

As bioprocessing moves toward greater automation, liquid handling robots are becoming integral to scaling operations. These systems can execute complex liquid transfer tasks with high precision, such as preparing E-Burettes, dilutions, or gradient feeds. Their programmability and consistency reduce manual intervention, minimizing errors and improving reproducibility.

The Future of Liquid Handling in Bioprocessing

As bioprocessing demands evolve, so do liquid handling technologies. Innovations such as contactless liquid handling, AI-driven automation, and smart sensors are set to revolutionize workflows, making processes more efficient, reproducible, and scalable. For bioprocessing professionals, investing in advanced liquid handling instrument ensures not only product quality but also operational excellence.

Whether in research or large-scale manufacturing, precision liquid handling is the foundation of successful bioprocessing. With the right instruments, organizations can achieve better control, reduce waste, and meet the stringent quality standards of today’s biopharma landscape.

[pakgent]

PakGent 1000 Medium Long Low Retention Adjustable Spacer Multichannel Pipette Tips

These 1000 medium long universal pipette tin is designed for use in molecular biology and biotechnology laboratories. They feature a medium-length design for easy access to deep wells and microplates. They are made from robust polypropylene and are compatible with a variety of pipettes and lab equipment. The tips can be put through an autoclave to make them sterile and ready for use.

Advantages of Using 1000 Medium Long Low Retention Pipette Tips

1000ul medium-long low retention pipette tips have several advantages in the laboratory.

Their low retention surface technology helps prevent sample loss, as well as the carryover of samples from one pipetting to another. This not only reduces waste but also saves time and ensures consistently accurate and reproducible results. The medium-long length of the pipette tips allows easy access to the bottom of tall vessel such as test tubes and flasks that have deeper depths.

Low retention pipette tips with 1000ul capacity also increase the sample size that can be pipetted, reducing the number of pipetting steps and the potential for procedural errors.

Overall, the use of 1000ul medium-long low retention pipette tips can enhance experimental accuracy and reduce the likelihood of contamination in the laboratory.

[techninja]

High-Throughput Pipetting: Multichannel Pipettes and Cutting-Edge Accessories at the Forefront

Introduction

Pipettes are essential laboratory instruments used for accurately measuring and transferring small volumes of liquid in various scientific and medical applications. They play a crucial role in a wide range of fields, including pharmaceuticals, biotechnology, clinical diagnostics, and academic research. The pipettes and accessories market is a dynamic and ever-evolving industry, driven by advancements in scientific research, healthcare, and diagnostic technologies. In this article, we will explore the key factors shaping the pipettes and accessories market, its growth prospects, and the innovative trends that are driving the industry forward.

Market Overview

The global pipettes and accessories market has been on a steady growth trajectory, with a compound annual growth rate (CAGR) of around 5% over the past few years. This growth can be attributed to several factors, including increased research and development activities in life sciences, growing demand for personalized medicine, and the expansion of the pharmaceutical and biotechnology sectors. Additionally, the COVID-19 pandemic highlighted the critical role of pipettes and other laboratory equipment in diagnostic testing and vaccine development, further driving market growth.

Types of Pipettes

The pipettes market comprises various types of pipettes, each designed for specific applications:

1. Manual Pipettes: These are the most commonly used pipettes and require human operation. They come in various volume capacities and are ideal for tasks that require precision and accuracy.

2. Electronic Pipettes: Also known as motorized or automatic pipettes, these are equipped with electronic components that enable precise volume control and reduce the risk of human error. Electronic pipettes are often used in high-throughput laboratories.

3. Multichannel Pipettes: These pipettes can dispense or aspirate multiple samples simultaneously, making them valuable for tasks that involve a high number of repetitive operations.

4. Single-Channel Pipettes: These pipettes are designed for handling a single sample at a time and are versatile for a wide range of applications.

5. Disposable Pipettes: Often made of plastic, these pipettes are used for applications where cross-contamination needs to be minimized.

Accessories and Innovations

The pipettes and accessories market isn't limited to just pipettes themselves. A wide range of accessories complements pipettes, including pipette tips, racks, and calibration equipment. The market for pipette tips, in particular, has witnessed significant growth, driven by the need for specialized tips that can handle various sample types, from viscous liquids to fragile cells.

Innovations in the pipettes and accessories market are driven by the demand for greater accuracy, reproducibility, and ease of use. Some notable trends include:

1. Advanced Ergonomics: Pipette manufacturers are focusing on ergonomic designs to reduce user fatigue and enhance comfort during prolonged pipetting tasks.

2. Digital Integration: Many electronic pipettes now feature digital interfaces that allow for easy programming and data logging. This integration streamlines workflows and enhances traceability.

3. Improved Calibration: Regular calibration is essential for maintaining pipette accuracy. Manufacturers are introducing innovative calibration tools and services to simplify this process.

4. Automation and Robotics: Automation in pipetting tasks is on the rise, particularly in high-throughput laboratories. Robotic systems that use pipettes are becoming more common, enabling precise and efficient sample handling.

5. Sustainability: With growing environmental awareness, there's a trend toward more sustainable pipette and accessory materials, as well as eco-friendly packaging.

Market Challenges

While the pipettes and accessories market presents significant opportunities, it also faces challenges, including the need for constant innovation to meet evolving research demands, increasing competition among manufacturers, and regulatory compliance. Additionally, supply chain disruptions, such as those seen during the COVID-19 pandemic, can impact the availability of critical pipetting equipment and accessories.

Conclusion

The pipettes and accessories market is vital to the progress of scientific research and healthcare. Its growth is fueled by the demand for precise and reliable liquid handling solutions in a wide range of applications. As the industry continues to evolve, manufacturers will need to stay at the forefront of technological advancements to meet the ever-increasing demands of researchers and scientists worldwide. With innovation and sustainability as guiding principles, the pipettes and accessories market is set to play a pivotal role in advancing scientific discovery and healthcare breakthroughs in the years to come.

[microlitt]

Innovative multichannel pipettes for handling liquids precisely

Multichannel pipettes have revolutionized the field of laboratory liquid handling by streamlining and expediting pipetting tasks. These versatile instruments are designed to simultaneously transfer multiple samples or reagents, significantly reducing the time and effort required for repetitive pipetting steps. With the ability to handle multiple channels, multichannel pipettes are ideal for scaling up experiments and increasing throughput without sacrificing accuracy and precision.

The most common multichannel pipettes are available in 8- or 12-channel configurations, perfectly spaced to work with 96- or even 384-well microplates. However, larger multichannel options and adjustable spacing versions cater to diverse experimental needs. By leveraging the capabilities of a multichannel pipette, researchers can accomplish in a few steps what would otherwise demand a much larger number of individual pipetting actions.

By employing a multichannel pipette in a scenario requiring 480 pipetting steps, one can accomplish the task with only 40 steps using a 12-channel pipette (5 rows of 8) or 60 steps with an 8-channel pipette (5 columns of 12). This expedited process not only accelerates plate filling but also minimizes the risk of repetitive strain injury (RSI) and the associated mental and physical fatigue. It is crucial to mitigate pipetting errors caused by fatigued analysts as they can compromise accuracy and precision, potentially leading to erroneous or inconclusive results. Consequently, repeating the assay becomes necessary, resulting in the wastage of valuable reagents, samples and reduced productivity.

While multichannel pipettes provide numerous advantages, they also present certain challenges, particularly concerning pipette tip attachment. Loading these tips can be cumbersome and often leads to uneven attachment. Difficulties such as problematic tip attachment, high ejection forces, and increased aspiration forces have impeded the proper utilization of multichannel pipettes. However, recent advancements in multichannel pipette technology have addressed these issues. For instance, electronic pipettes with electronic pistons and/or tip ejection mechanisms have been developed to overcome these challenges. Manufacturing breakthroughs have also improved tip attachment consistency, resulting in enhanced accuracy and precision. Nevertheless, it is important to note that even with these technological advancements, the critical factor for optimal performance lies in the proficiency of a well-trained operator who utilizes a calibrated multichannel pipette for each channel.

Enhancing Pipetting Proficiency: Essential Techniques for Multichannel Pipetting Success

To achieve accurate and reliable results when using multichannel pipettes, proper technique is of utmost importance, as operator variability can quickly lead to errors. Here are essential techniques to consider when utilizing these devices:

Mindful Tip Application: Always opt for manufacturer-approved pipette tips and select those with the smallest air gap. After aspirating the sample, compare the liquid levels within the tips. If uneven, it may indicate inconsistent tip placement across the pipette channels.

Pre-Wet Pipette Tips: Pre-wetting the pipette tips is crucial. This process humidifies the captive air space (air cushion) within the tips, minimizing sample evaporation and the risk of pipette dripping.

Slow and Steady Aspiration: Rapid plunger movements or fast aspiration can introduce unwanted bubbles within the pipette tips. To avoid this, ensure a controlled and gradual aspiration process.

Vertical Aspiration, Minimizing Angles: When aspirating, it is important to maintain a vertical position without tilting or angling the pipette. Angling the pipette in various directions, such as forward-backward or left-right, can result in uneven immersion depths of the pipette tips, leading to inconsistent volume transfer.

Essential Pause After Aspiration: Once the plunger is released, pause for a full second with the tips still immersed in the sample. This pause allows the total sample volume to fully enter each pipette tip, ensuring uniformity across all channels.

Adjusting Dispense Speed: Sometimes, a slower dispense speed may result in residual samples remaining in the pipette tips. If you observe residual droplets, it may indicate the need to adjust the dispense speed to a faster rate. This adjustment ensures that the captive air space above the sample generates enough force to push the entire sample out of the pipette tips.

Tip-Touch or Brush-Off Technique: During dispensing, whenever feasible, gently touch the pipette tips against the side walls of the plate or receptacle. Alternatively, you can dispense the sample on top of the solution. These actions create added surface tension, aiding in complete sample removal and reducing the likelihood of residual sample retention.

By employing these techniques, you can enhance the efficiency and accuracy of multichannel pipetting, ensuring complete sample transfer and minimizing potential sources of error.