#maybe how the virus affected other primates

[sleepnavigator]

what if we got to see how apes in other countries took over or are living relatively peacefully with humans

[theantarwitch]

Non human Ancestors

I was just thinking... often I see a lot about ancestor work (something that I don’t actually do for reasons lol) which is mostly aimed to human ancestors, our beloved past generations that we never were able to know; but I was taking a shower and it occurred to me: What about our ancestors that are so back in time that are not even human? They existed, right?

Specially having in mind that humans (“modern” humans) are actually so new in the big scheme of the evolution line. As someone said, from Jesus (Year 0) to now, to around 30 years between generations, there are around 56 mothers long (some put up to 80 or 100 mothers). Which is an actually ridiculously small fragment of time. Don’t get me wrong, is a lot of time to us, but the earth is quite oldy. Also, interesting fact: 1 generation ago you have 2 parents, 2 generations ago you have 4 grandparents… 56 generations ago you have 16,000,000,000,000,000 ancestors! So each time you do ancestor work, you have a little army up there lol.

Back to what matters. There were humans before the year 0. There was a moment when they were not even humans, but their evolved blood still flows on out veins, their evolutionary bias still affects us. We find calmness on the shower because we once were living on the water. Our strong emotional based reactions come from the times where our rational thinking wasn’t a thing. The appendix is considered a small leftover from one of our plant-eating ancestors. The coccyx is all that remains of our ancestral tails. Humans pay extra attention to the red color because was a sign of a ripe fruit (and blood). Hiccups might be attributed to an ancient amphibian ancestor. That we and other mammals have 5 fingers is rooted to a dang fish! Our fear of dark, the way we unconsciously analyze others, how we manage to unconsciously pick the “best partner”, the virus and bacteria that live in our bodies in a symbiotic way, and so on. Almost all what we are now, mentally, emotionally and physically, is a result of millions of years of evolution, of species that don’t look like us. An almost endless line of lucky and well adapted creatures, in a web of evolution, trial and error, until now. So why only focus on our modern human ancestors? One of you ancient grandmothers was a “fish”, she did her part and she know things that we have no idea, so why don’t ask them for aid?  

From the Homo Sapiens (Us, in the last 500.000 years) with their extreme mental developed brains, their, inventive, problem solving, creativity, to the Homo Erectus being the first to cook food (controlled fire), to make handaxes, to hunt and gather in coordinated groups, in caring for injured or sick group members, to walk fully straight as us; to the Australopithecus, and back to our unknown Hominini “Missing Link”.

From the Purgatorius, the progenitor of primates, to the Pelycosaur, the one from which Sauropsids (the ancestors of reptiles of all sorts) and of Synapsids (that's mammals AND their ancestors) split off from.

From the Hylonomus, the first reptile, to the Tiktaalik, the first fish in venture to leave the ocean and walk in the earth, to the Agnatha, the first fish.

To the Urmetazoan, the hypothetical last common ancestor of all animals.

3.7 billion years old of ancestors. I think is poetic to think about it. The spirit of some Homo Erectus getting happy when you lit a candle, the Tiktaalik’s spirit noticing how you are in ease when you take a long shower, a fluffy Synapsids’s energy remembering their old times when you sleep comfy on your bed, an anxious Purgatorius’s spirit who see you eat your veggies just like they did… So many unknown ancestors, from the most primitive form of life, seeing their evolutionary mark on you.  

I don’t know, maybe is time to drop a snack in their name, who knows which knowledge they can bring us back, from their experiences in a time where life wasn’t easy, from a time where the earth wasn’t even remotely similar to our earth now. We are almost aliens to them, but we carry them, deep inside our DNA. Who knows in which funky animalistic way they can aid us? Is worthy to think about it, at least for a while. They deserve the recognition too…

[dailynewswebsite]

Explainer: How clinical trials test COVID-19 vaccines

A lab technician holds a vial of a COVID-19 vaccine candidate throughout testing on the Chula Vaccine Analysis Heart, run by Chulalongkorn College in Bangkok, Thailand on Might 25, 2020. (AP Photograph/Sakchai Lalit)

On Sept. 4, 2020, President Donald Trump introduced that we’ll have a vaccine for COVID-19 “earlier than the tip of the yr and perhaps even earlier than Nov. 1.” As an election looms in the US, the declaration fuelled fear {that a} COVID-19 vaccine could also be authorized earlier than scientific vetting is full.

In the US, evaluation and licensure of vaccines is the duty of the Meals and Drug Administration (FDA). However the company’s dealing with of emergency use authorizations for 2 anti-malaria medication and convalescent blood plasma for the remedy of COVID-19 have led to claims it has grow to be politicized.

Blood samples from volunteers are dealt with within the laboratory at Imperial School in London, on July 30, 2020. Imperial School is engaged on the event of a COVID-19 vaccine. (AP Photograph/Kirsty Wigglesworth)

Such is the fear in regards to the impartiality of the FDA that pharmaceutical firms drew a line within the sand and pledged publicly to “solely submit [a vaccine] for approval or emergency use authorization after demonstrating security and efficacy by means of a Section three scientific research.”

“Hell has frozen over,” remarked commentators.

However what’s a Section three scientific research? And the way does scientific testing present us with dependable proof that vaccines not solely work however are secure?

Vaccine growth

Vaccine growth could be regarded as the method of separating the components of an infectious agent that make us sick, from people who induce an immune response and shield us from future an infection. As this separation could be achieved in myriad methods, vaccines are various.

Vaccine candidates for COVID-19 illustrate these various approaches. Some, similar to SinoPharm’s inactivated coronavirus vaccine, use killed entire coronavirus. Others, such because the Oxford College-AstraZeneca vaccine, modify a special virus (on this case, chimpanzee adenovirus) to specific coronavirus proteins. But others, similar to Moderna’s mRNA vaccine, use solely small bits of viral genetic materials.

In Canada, the oversight of vaccines is shared by Well being Canada and the Public Well being Company of Canada. The scientific analysis of vaccines includes animal testing, human scientific trials and post-approval surveillance. In lots of regards, the analysis of vaccines is similar as the method for medication. As a result of vaccines are given to wholesome individuals, nonetheless, there’s a fair better emphasis in vaccine testing on security.

Animal testing

Step one in evaluating a vaccine is animal testing. Animals are given differing doses of vaccine to test for adversarial occasions and an immune response.

Because the virus that causes COVID-19 is new, there was no animal mannequin for the illness. Current work has demonstrated that ferrets, cats and a few non-human primates are liable to an infection and may unfold it to others. Animal testing offers details about security (and maybe efficacy) earlier than a vaccine is examined on people.

What’s vaccine growth, and the way can it’s finished sooner throughout a pandemic?

Human scientific trials

Human testing in scientific trials is split into three phases. Making certain the protection of a vaccine is the prime concern by means of all phases of scientific trials. Vaccine efficacy is evaluated in several methods throughout the trial spectrum. Early-phase trials search for the manufacturing of antibodies in opposition to the virus, whereas late-phase trials consider whether or not the vaccine in actual fact prevents individuals from getting sick.

Section 1 trials are the primary evaluations of a vaccine in people. These trials recruit 10 to 100 wholesome volunteers who obtain completely different doses of vaccine. Frequent adversarial occasions to a vaccine embrace redness or soreness on the injection web site, muscle pains, headache and fever. Blood can also be drawn from the volunteers to evaluate the immune response to the vaccine, significantly the rise in antibodies and whether or not antibody ranges are much like these in individuals who have had the illness.

Section 2 vaccine trials are much like Section 1 trials when it comes to their concentrate on adversarial occasions and immune response. Section 2 trials, nonetheless, embrace lots of of wholesome volunteers who’re extra various to provide a greater indication of the protection and immune response in individuals more likely to obtain the vaccine sooner or later.

Pharmacist Michael Witte, left, offers Rebecca Sirull, proper, a shot within the first-stage security research scientific trial of a possible vaccine for COVID-19 on March 16, 2020, on the Kaiser Permanente Washington Well being Analysis Institute in Seattle. Sirull was the third affected person to obtain the shot within the research. (AP Photograph/Ted S. Warren)

As Section 1 and a pair of trials contain comparatively small numbers of individuals, they solely give us info on vaccine side-effects which might be quite common (affecting greater than 10 per cent of individuals) and customary (affecting multiple per cent of individuals). Vaccine efficacy is barely evaluated not directly by means of measuring antibody ranges.

It’s only the Section three trials that may present a pivotal demonstration {that a} vaccine each works and is secure. Section three vaccine trials are massive randomized managed trials performed locally. In these trials individuals both obtain the vaccine or a placebo. If fewer individuals who acquired the vaccine grow to be sick in comparison with those that acquired placebo, now we have direct proof that the vaccine prevents illness.

Learn extra: Ethics should not be ignored when testing COVID-19 vaccines

A Section three trial could contain tens of hundreds of volunteers who obtain the vaccine, additional offering dependable info on adversarial occasions, together with these which might be unusual (affecting fewer than one per cent of individuals) or uncommon (affecting fewer than 0.1 per cent of individuals).

A vaccine could also be licensed to be used after a profitable Section three trial.

Of the 321 vaccines for COVID-19 in growth, 27 are in Section 1 or 2 trials and 6 are being evaluated in Section three trials. In complete, these trials search to enrol 280,000 individuals from 34 nations. No COVID-19 vaccine has been licensed in Canada or the US.

Submit-approval surveillance

As soon as a vaccine is licensed, continued monitoring for security is vital. Dependable detection of very uncommon (affecting fewer than 0.01 per cent of individuals) vaccine adversarial occasions requires info on lots of of hundreds of individuals. The Canadian Adversarial Occasions Following Immunization Surveillance System screens the protection of marketed vaccines, publishes studies frequently and identifies the necessity for additional research ought to a security concern be recognized.

Offered {that a} COVID-19 vaccine efficiently navigates human scientific trials and is subjected to persevering with security monitoring after it’s licensed, now we have good grounds to imagine that the vaccine each works and is secure.

Charles Weijer consults with Cardialen, Eli Lilly & Firm, and Analysis Triangle Institute (RTI) Worldwide.

from Growth News https://growthnews.in/explainer-how-clinical-trials-test-covid-19-vaccines/ via https://growthnews.in

[dorcasrempel]

Study analyzes contamination in drug manufacturing plants

Over the past few decades, there have been a handful of incidents in which manufacturing processes for making protein drugs became contaminated with viruses at manufacturing plants. These were all discovered before the drugs reached patients, but many of the incidents led to costly cleanups and in one instance a drug shortage.

A new study from an MIT-led consortium has analyzed 18 of these incidents, most of which had not been publicly reported until now. The report offers insight into the most common sources of viral contamination and makes several recommendations to help companies avoid such incidents in the future.

While the study focused on biopharmaceuticals (protein drugs produced by living cells), the findings could also help biotech companies to create safety guidelines for the manufacture of new gene therapies and cell-based therapies, many of which are now in development and could face similar contamination risks.

“As the biotech industry starts to think about manufacturing these really exciting new products, which are highly effective and even in some cases curative, we want to make sure that the viral safety aspects of manufacturing them are considered,” says Stacy Springs, senior director of programs for MIT’s Center for Biomedical Innovation (CBI).

Springs is the senior author of the study, which appears today in Nature Biotechnology. Paul Barone, co-director of the CBI’s Biomanufacturing Program and director of the Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB), is the lead author. The other authors from CBI are Michael Wiebe and James Leung.

Sharing information

Many therapeutic proteins are produced using recombinant DNA technology, which allows bacterial, yeast, or mammalian cells to be engineered to produce a desired protein. While this practice has a strong safety record, there is a risk that the cultured mammalian cells can be infected with viruses. The CAACB, which performed the study, was launched in 2010 following a well-publicized contamination incident at a Genzyme manufacturing plant in Boston. The plant had to shut down for about 10 months when some of its production processes became infected with a virus in 2009. 

When such incidents occur, drug companies aren’t required to make them public unless the incident affects their ability to provide the drug. The CBI team assembled a group of 20 companies that were willing to share information on such incidents, on the condition that the data would be released anonymously.

“We thought it would be very valuable to have industry share their experience of viral contamination, since most companies have had none of these incidents if they’re lucky, or maybe one or two at the most,” Springs says. “All of that knowledge about how they discovered and managed the event, identified the virus and its source, disinfected and restarted the production facility, and took action to prevent a recurrence was all siloed within individual companies.”

The study, which focused on protein drugs produced by mammalian cells, revealed 18 viral contamination incidents since 1985. These occurred at nine of the 20 biopharmaceutical companies that reported data. In 12 of the incidents, the infected cells were Chinese hamster ovary (CHO) cells, which are commonly used to produce protein drugs. The other incidents involved human or nonhuman primate cells.

The viruses that were found in the human and nonhuman primate cells included herpesvirus; human adenovirus, which causes the common cold; and reovirus, which can cause mild gastroenteritis. These viruses may have spread from workers at the plants, the researchers suggest.

In many cases, contamination incidents were first detected because cells were dying or didn’t look healthy. In two cases, the cells looked normal but the viral contamination was detected by required safety testing. The most commonly used test takes at least two weeks to yield results, so the contaminating virus can spread further through the manufacturing process before it is detected.

Some companies also use a faster test based on polymerase chain reaction (PCR) technology, but this test has to be customized to look for specific DNA sequences, so it works best when the manufacturers know of specific viruses that are most likely to be found in their manufacturing processes.

“This work demonstrates how sharing of data and information yield better understanding of difficult problems in manufacturing biologics,” says Janet Woodcock, director of the Center for Drug Evaluation and Research at the FDA, who was not involved in the study. “Innovators contemplating new processes or product may be able to avoid pitfalls or disasters by learning from the collective past experiences documented here.”

New technology

Many of the CAACB member companies are exploring new technologies to inactivate or remove viruses from cell culture media before use, and from products during purification. Additionally, companies are developing rapid virus detection systems that are both sensitive and able to detect a broad spectrum of viruses.

CBI researchers are also working on several technologies that could enable more rapid tests for viral contamination. Much of this research is taking place within a new interdisciplinary research group at the Singapore-MIT Alliance for Science and Technology (SMART), called the Critical Analytics for Manufacturing Personalized Medicines. Led by Krystyn Van Vliet, MIT associate provost and a professor of biological engineering and materials science and engineering, this group, which includes several other MIT faculty members from across departments, is working on about half a dozen technologies to more rapidly detect viruses and other microbes.

“I think that there’s a lot of potential for technology development to ameliorate some of the challenges we see,” Barone says.

Another strategy that the report recommends, and that some companies are already using, is to reduce or eliminate the use of cell growth medium components that are derived from animal products such as bovine serum. When that isn’t possible, another strategy is to perform virus removal or inactivation processes on media before use, which can prevent viruses from entering and contaminating manufacturing processes. Some companies are using a pasteurization-like process called high temperature short time (HTST) treatment, while others use ultraviolet light or nanofiltration.

The researchers hope that their study will also help guide manufacturers of new gene- and cell-therapy products. These therapies, which make use of genes or cells to either replace defective cells or produce a therapeutic molecule within the body, could face similar safety challenges as biopharmaceuticals, the researchers say, as they are often grown in media containing bovine serum or human serum.

“Having done this sharing of information in a systematic way, I think we can accelerate the dissemination of information on best practices, not only within the protein manufacturing industry but also the new industry of cell-based modalities,” says James Leung.

The research was funded by the members of the CAACB.

Study analyzes contamination in drug manufacturing plants syndicated from https://osmowaterfilters.blogspot.com/

[scienceblogtumbler]

Study analyzes contamination in drug manufacturing plants

Over the past few decades, there have been a handful of incidents in which manufacturing processes for making protein drugs became contaminated with viruses at manufacturing plants. These were all discovered before the drugs reached patients, but many of the incidents led to costly cleanups and in one instance a drug shortage.

A new study from an MIT-led consortium has analyzed 18 of these incidents, most of which had not been publicly reported until now. The report offers insight into the most common sources of viral contamination and makes several recommendations to help companies avoid such incidents in the future.

While the study focused on biopharmaceuticals (protein drugs produced by living cells), the findings could also help biotech companies to create safety guidelines for the manufacture of new gene therapies and cell-based therapies, many of which are now in development and could face similar contamination risks.

“As the biotech industry starts to think about manufacturing these really exciting new products, which are highly effective and even in some cases curative, we want to make sure that the viral safety aspects of manufacturing them are considered,” says Stacy Springs, senior director of programs for MIT’s Center for Biomedical Innovation (CBI).

Springs is the senior author of the study, which appears today in Nature Biotechnology. Paul Barone, co-director of the CBI’s Biomanufacturing Program and director of the Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB), is the lead author. The other authors from CBI are Michael Wiebe and James Leung.

Sharing information

Many therapeutic proteins are produced using recombinant DNA technology, which allows bacterial, yeast, or mammalian cells to be engineered to produce a desired protein. While this practice has a strong safety record, there is a risk that the cultured mammalian cells can be infected with viruses. The CAACB, which performed the study, was launched in 2010 following a well-publicized contamination incident at a Genzyme manufacturing plant in Boston. The plant had to shut down for about 10 months when some of its production processes became infected with a virus in 2009.

When such incidents occur, drug companies aren’t required to make them public unless the incident affects their ability to provide the drug. The CBI team assembled a group of 20 companies that were willing to share information on such incidents, on the condition that the data would be released anonymously.

“We thought it would be very valuable to have industry share their experience of viral contamination, since most companies have had none of these incidents if they’re lucky, or maybe one or two at the most,” Springs says. “All of that knowledge about how they discovered and managed the event, identified the virus and its source, disinfected and restarted the production facility, and took action to prevent a recurrence was all siloed within individual companies.”

The study, which focused on protein drugs produced by mammalian cells, revealed 18 viral contamination incidents since 1985. These occurred at nine of the 20 biopharmaceutical companies that reported data. In 12 of the incidents, the infected cells were Chinese hamster ovary (CHO) cells, which are commonly used to produce protein drugs. The other incidents involved human or nonhuman primate cells.

The viruses that were found in the human and nonhuman primate cells included herpesvirus; human adenovirus, which causes the common cold; and reovirus, which can cause mild gastroenteritis. These viruses may have spread from workers at the plants, the researchers suggest.

In many cases, contamination incidents were first detected because cells were dying or didn’t look healthy. In two cases, the cells looked normal but the viral contamination was detected by required safety testing. The most commonly used test takes at least two weeks to yield results, so the contaminating virus can spread further through the manufacturing process before it is detected.

Some companies also use a faster test based on polymerase chain reaction (PCR) technology, but this test has to be customized to look for specific DNA sequences, so it works best when the manufacturers know of specific viruses that are most likely to be found in their manufacturing processes.

“This work demonstrates how sharing of data and information yield better understanding of difficult problems in manufacturing biologics,” says Janet Woodcock, director of the Center for Drug Evaluation and Research at the FDA, who was not involved in the study. “Innovators contemplating new processes or product may be able to avoid pitfalls or disasters by learning from the collective past experiences documented here.”

New technology

Many of the CAACB member companies are exploring new technologies to inactivate or remove viruses from cell culture media before use, and from products during purification. Additionally, companies are developing rapid virus detection systems that are both sensitive and able to detect a broad spectrum of viruses.

CBI researchers are also working on several technologies that could enable more rapid tests for viral contamination. Much of this research is taking place within a new interdisciplinary research group at the Singapore-MIT Alliance for Science and Technology (SMART), called the Critical Analytics for Manufacturing Personalized Medicines. Led by Krystyn Van Vliet, MIT associate provost and a professor of biological engineering and materials science and engineering, this group, which includes several other MIT faculty members from across departments, is working on about half a dozen technologies to more rapidly detect viruses and other microbes.

“I think that there’s a lot of potential for technology development to ameliorate some of the challenges we see,” Barone says.

Another strategy that the report recommends, and that some companies are already using, is to reduce or eliminate the use of cell growth medium components that are derived from animal products such as bovine serum. When that isn’t possible, another strategy is to perform virus removal or inactivation processes on media before use, which can prevent viruses from entering and contaminating manufacturing processes. Some companies are using a pasteurization-like process called high temperature short time (HTST) treatment, while others use ultraviolet light or nanofiltration.

The researchers hope that their study will also help guide manufacturers of new gene- and cell-therapy products. These therapies, which make use of genes or cells to either replace defective cells or produce a therapeutic molecule within the body, could face similar safety challenges as biopharmaceuticals, the researchers say, as they are often grown in media containing bovine serum or human serum.

“Having done this sharing of information in a systematic way, I think we can accelerate the dissemination of information on best practices, not only within the protein manufacturing industry but also the new industry of cell-based modalities,” says James Leung.

The research was funded by the members of the CAACB.

source https://scienceblog.com/515865/study-analyzes-contamination-in-drug-manufacturing-plants/

[jeffrmayhugh]

BREAKING NEWS: DONALD TRUMP BUYING BITCOIN!!! | [April fools JOKE]

VIDEO TRANSCRIPT

In this video, major, major news, Donald Trump, the president of the United States, has just changed his mind about Bitcoin, he says I’m buying Bitcoin, the Chinese virus is spreading and the Fed is printing unlimited dollars. So far so good. But if the dollar weakens, we need a backup. He tweeted this tweet just 40 minutes ago and it’s already gone completely viral. I remember the tweet he tweeted just a couple of months ago when he said that he’s not a fan of Bitcoin. Well, times they are changing. And now Donald Trump has completely changed his view and he’s actually officially buying Bitcoin. And other than that, I’m also going to take a look at the big comprise. I want to talk about where the Beacon press is heading in the immediate future. And if you think that that sounds interesting, then I think that you should definitely be. Hello, guys. And welcome to the Moon. My name is Carlin. I’m here to bring you this cryptocurrency video. And let’s take a look at the bit comprise because, well, yesterday I had a lot of comments about potential head and shoulders pattern. So I want to talk about it. But before I talk about the head and shoulders pattern, I just want to quickly talk more about the fact that Donald Trump, the president of the United States, is actually buying bitcoin. And this is, of course, not true. Obviously, this is just a big joke. I was just messing around, guys. And this is not a real tweet from Donald Trump. It’s April Fools, guys. It’s the first of April. So I hope you enjoyed that little joke. And it’s actually really easy to change tweets like this. I can just do this and then inspect and then this will pop up and I can just click here and this will allow me to write anything here, for example, like this and then press enter it. And now we can see how it says don’t buy Bitcoin said so. Sorry, guys, I just thought that was a very funny way to fool you guys. But just to clarify. Donald Trump is not buying bitcoin. At least I don’t think so. And if you liked that little joke, just leave it thumbs up down below. But let’s take a look at the bitcoin price. All right. So yesterday I had many comments about a potential head and shoulders pattern. And ahead and shoulders pattern is, of course, a bearish pattern. It confirms. And the thing about these head and shoulders patterns is that they mean nothing if they don’t break down below the neckline. And if they break the neckline, then that’s when you can make a trade. And in this case, it would be short. So let’s take a look at this. Well, the first problem I see is that here on Coinbase, this shoulder is higher than this head, a shoulder, head and shoulder. Needs to have the shoulders below the head and on Coinbase. We can see that this is actually higher. And that would tell me that maybe this is not a head and shoulders pattern. However, if you go over to buy NANCE, we can see that the head, in this case, is indeed higher than the shoulder. And well, I’m just gonna make the targeted analysis for everyone who wants to know. But personally, I am not really too comfortable with calling this a head and shoulders pattern because of these small in inconsistencies here. But this is how you measure the targets. And if it breaks down below the neckline, then the technical target should be all the way down here at four thousand eight hundred and sixty-two, approximately a little bit, depending on exactly where this breaks down, obviously. And something that could go well with this theory is that we do see the volume go down, as I’ve pointed out previously. And the thing is that when volume goes down while the price is going up, then usually this means that we shouldn’t really trust the current price action. Basically, this means that this uptrend might not be sustainable. So let me just show you exactly what this means. Basically, when we have an option like this, we would like to see the volume remain the same or preferably actually go up as the price is going up. However, if the volume is going down, as the price is going up, then usually this is a sign that this is this move is getting exhausted and we’re running out of buyers basically. And we shouldn’t really trust this price action. And the same goes, of course, for the other way around. Does this mean that Bitcoin is going to break down? Well, no. It doesn’t necessarily mean that, but it does mean that we are in a consolidation phase. And I wouldn’t really trust the current price, actually, because the volume is really coming down. And I would say that as long as the volume continues to go down like this, we won’t see any major trend changes. We will probably stay within this range. We have the resistance up here at approximately six point eight thousand and we have support. I would probably put the sport box over here at somewhere between four points eight and five-point one thousand as long as the volume is low. I would expect the bitcoin price to continue to trade within this range. But like I’ve said so many times when we see declining volume like this, usually, we see this end with a bang, a huge break. And this is exactly what we should be expecting. Big volatility will soon come because right now we’re seeing low volatility, low volume, and some people would call this boring. And I think we could also potentially watch the potential scenario where an ascending triangle might be for me. But I think it’s a little bit early to say that this is an ascending triangle right now. But let’s just keep an eye on this resistance up here at six points eight. And let’s keep an eye on this opportunity support here, which could be this potential neckline of a potential head and shoulders. But like I said, I’m not really too convinced that this is an accurate tt’s shoulders pattern because of the inconsistencies. And if you are an experienced trader and if you’re looking for a platform to trade Bitcoin, these are the platforms that I personally recommend by beat fee mix primates. SBT links down below in the pained comments. And by the way, just a side note, it seems like someone just a few hours ago on crack-in. Bought a thousand bitcoin, and whether this is an institution, a whale or someone who just accidentally bought 1000 thousand Bitcoin like this. I don’t know. Usually, you would see people do these kinds of deals over the counter LTC because this will maybe lower the spread a little bit and you won’t affect the price. So personally, I’m not too sure about exactly what happened here, but you can see this massive volume spike spiking straight up here on cracking and you can see how this candle looks quite amazing actually. But yeah, I don’t have any insider information to share with you guys. I just want to quickly tell you that someone just bought the thousand bitcoin. And by the way, guys, if you are not one of us subscribers yet, please go down below this video. Click subscribe and you can also click lisle Bell. And if you know, click all here, then you will be notified as soon as I upload my next daily video. And over on coin market cap, will you see that toilet paper token has currently taken over the number one spot on core market cap? And I mean we know the bitcoins circulating supply is closing in on 21 million, but the circulating supply of toilet paper talking is out of stock. And next up, I have been alive for twenty-five years and so far twenty is the craziest year. I mean, first of all, we have the big virus spreading. People are very fearful about the virus and the economy shutting down. And we also see central banks completely forgetting about all the previous rules and just completely printing money and just doing all of this massive financial stimulus, unlike anything we have ever witnessed before. So we are truly witnessing history in the making. And I think the next few years will bring about a big change to the world. And more specifically, I think that this change will be most noticeable in the economy and potentially in the monetary system as we know it today. And I want to share this quote with you. And some people say that this quote is completely fake. Some people say that it’s just a little bit altered. But I want to share it regardless because it’s a very powerful quote. So supposedly Thomas Jefferson said this. I believe that banking institutions are more dangerous to our liberties than standing armies. If the American people ever allow private banks to control the issue of their currency, first by inflation, then by deflation, the banks and corporations that will grow up around the banks will deprive the people of all property until their children wake up homeless on the continent their fathers conquered. Now, I’m not sure of the full quote is accurate, but I’m pretty sure that the first line here is accurate. I believe that banking institutions are more dangerous to our liberties than standing armies. It is a very, very famous quote. And today. Exactly. This is what’s happening. We are seeing the private banks controlling the issuance of our money or our currency. First, the central banks create money out of thin air. They buy assets from the. From the open market. And then these newly printed currency ends up in the banking system. And the banks can then use this currency to create even more credit. On top of this money, so they can expand the money supply tenfold, 30 fold, even 50 fold in some cases. So through credits, private banks create currency, which is used as money around the world. And that is extremely, extremely dangerous because this means that we have a central authority. Private banks that completely control the money and money is such an important thing for freedom and for control. And the more control someone has over the money than the less freedom everyone else has. And like I said earlier in this video, I think that the next two years will bring about big change. And we’re already seeing people talk about unemployment rates going much, much higher. For example, Goldman Sachs says that the US economy will experience a far deeper slump than previously anticipated. For example, they say here that unemployment will soar to 15 percent by mid-year, up from a previous forecast of 9 percent. They wrote, obviously, these are estimates, but we also see the Federal Reserve. They expect the unemployment rate to hit 32 percent. This is a Fed estimate. So we’re seeing most institutions now talk about high unemployment rates. And I think that it’s quite reasonable to expect that to happen, not only because of the massive debts around the world but also because of the current fears surrounding the virus. So they say that there are nearly 67 million Americans working in jobs that are at a high risk of layoffs. And this is not only true for the US. This is true for countries globally. And according to this Federal Reserve economist, Miguel Ferrer. Castro, he says that, quote, These are very large numbers by historical standards, but this is a rather unique shock that is unlike any other experienced by the U.S. economy. The last one hundred years. And this is a reference to the Great Depression, of course, which happened just over 100 years ago. And remember, guys, for the past two years on my channel, I’ve been talking about the coming recession. The coming crisis will be much worse than the 2008 financial crisis, and it will probably be even worse than the Great Depression. Based on all of the fundamentals, the debt levels, the monetary stimulus and the actions by the central banks, the private banks and all the corporations and even all private individuals just using death and credit as an as in a very, very irresponsible way. And now finally, we’re seeing media covering the threats to the economy that we’re seeing currency. And guys, if you enjoy this video and if you liked my April Fool’s joke about Donald Trump, please go down, leave thumbs up. Let’s see if we can push this video to four thousand likes. Thank you very much for watching this video. And if you haven’t seen my BYB, it’s tutorial links right there right now. And I’ll see you guys tomorrow.

source https://www.cryptosharks.net/breaking-news-donald-trump-buying-bitcoin/ source https://cryptosharks1.tumblr.com/post/614240109726924800

[heatherrdavis1]

BREAKING NEWS: DONALD TRUMP BUYING BITCOIN!!! | [April fools JOKE]

VIDEO TRANSCRIPT

In this video, major, major news, Donald Trump, the president of the United States, has just changed his mind about Bitcoin, he says I’m buying Bitcoin, the Chinese virus is spreading and the Fed is printing unlimited dollars. So far so good. But if the dollar weakens, we need a backup. He tweeted this tweet just 40 minutes ago and it’s already gone completely viral. I remember the tweet he tweeted just a couple of months ago when he said that he’s not a fan of Bitcoin. Well, times they are changing. And now Donald Trump has completely changed his view and he’s actually officially buying Bitcoin. And other than that, I’m also going to take a look at the big comprise. I want to talk about where the Beacon press is heading in the immediate future. And if you think that that sounds interesting, then I think that you should definitely be. Hello, guys. And welcome to the Moon. My name is Carlin. I’m here to bring you this cryptocurrency video. And let’s take a look at the bit comprise because, well, yesterday I had a lot of comments about potential head and shoulders pattern. So I want to talk about it. But before I talk about the head and shoulders pattern, I just want to quickly talk more about the fact that Donald Trump, the president of the United States, is actually buying bitcoin. And this is, of course, not true. Obviously, this is just a big joke. I was just messing around, guys. And this is not a real tweet from Donald Trump. It’s April Fools, guys. It’s the first of April. So I hope you enjoyed that little joke. And it’s actually really easy to change tweets like this. I can just do this and then inspect and then this will pop up and I can just click here and this will allow me to write anything here, for example, like this and then press enter it. And now we can see how it says don’t buy Bitcoin said so. Sorry, guys, I just thought that was a very funny way to fool you guys. But just to clarify. Donald Trump is not buying bitcoin. At least I don’t think so. And if you liked that little joke, just leave it thumbs up down below. But let’s take a look at the bitcoin price. All right. So yesterday I had many comments about a potential head and shoulders pattern. And ahead and shoulders pattern is, of course, a bearish pattern. It confirms. And the thing about these head and shoulders patterns is that they mean nothing if they don’t break down below the neckline. And if they break the neckline, then that’s when you can make a trade. And in this case, it would be short. So let’s take a look at this. Well, the first problem I see is that here on Coinbase, this shoulder is higher than this head, a shoulder, head and shoulder. Needs to have the shoulders below the head and on Coinbase. We can see that this is actually higher. And that would tell me that maybe this is not a head and shoulders pattern. However, if you go over to buy NANCE, we can see that the head, in this case, is indeed higher than the shoulder. And well, I’m just gonna make the targeted analysis for everyone who wants to know. But personally, I am not really too comfortable with calling this a head and shoulders pattern because of these small in inconsistencies here. But this is how you measure the targets. And if it breaks down below the neckline, then the technical target should be all the way down here at four thousand eight hundred and sixty-two, approximately a little bit, depending on exactly where this breaks down, obviously. And something that could go well with this theory is that we do see the volume go down, as I’ve pointed out previously. And the thing is that when volume goes down while the price is going up, then usually this means that we shouldn’t really trust the current price action. Basically, this means that this uptrend might not be sustainable. So let me just show you exactly what this means. Basically, when we have an option like this, we would like to see the volume remain the same or preferably actually go up as the price is going up. However, if the volume is going down, as the price is going up, then usually this is a sign that this is this move is getting exhausted and we’re running out of buyers basically. And we shouldn’t really trust this price action. And the same goes, of course, for the other way around. Does this mean that Bitcoin is going to break down? Well, no. It doesn’t necessarily mean that, but it does mean that we are in a consolidation phase. And I wouldn’t really trust the current price, actually, because the volume is really coming down. And I would say that as long as the volume continues to go down like this, we won’t see any major trend changes. We will probably stay within this range. We have the resistance up here at approximately six point eight thousand and we have support. I would probably put the sport box over here at somewhere between four points eight and five-point one thousand as long as the volume is low. I would expect the bitcoin price to continue to trade within this range. But like I’ve said so many times when we see declining volume like this, usually, we see this end with a bang, a huge break. And this is exactly what we should be expecting. Big volatility will soon come because right now we’re seeing low volatility, low volume, and some people would call this boring. And I think we could also potentially watch the potential scenario where an ascending triangle might be for me. But I think it’s a little bit early to say that this is an ascending triangle right now. But let’s just keep an eye on this resistance up here at six points eight. And let’s keep an eye on this opportunity support here, which could be this potential neckline of a potential head and shoulders. But like I said, I’m not really too convinced that this is an accurate tt’s shoulders pattern because of the inconsistencies. And if you are an experienced trader and if you’re looking for a platform to trade Bitcoin, these are the platforms that I personally recommend by beat fee mix primates. SBT links down below in the pained comments. And by the way, just a side note, it seems like someone just a few hours ago on crack-in. Bought a thousand bitcoin, and whether this is an institution, a whale or someone who just accidentally bought 1000 thousand Bitcoin like this. I don’t know. Usually, you would see people do these kinds of deals over the counter LTC because this will maybe lower the spread a little bit and you won’t affect the price. So personally, I’m not too sure about exactly what happened here, but you can see this massive volume spike spiking straight up here on cracking and you can see how this candle looks quite amazing actually. But yeah, I don’t have any insider information to share with you guys. I just want to quickly tell you that someone just bought the thousand bitcoin. And by the way, guys, if you are not one of us subscribers yet, please go down below this video. Click subscribe and you can also click lisle Bell. And if you know, click all here, then you will be notified as soon as I upload my next daily video. And over on coin market cap, will you see that toilet paper token has currently taken over the number one spot on core market cap? And I mean we know the bitcoins circulating supply is closing in on 21 million, but the circulating supply of toilet paper talking is out of stock. And next up, I have been alive for twenty-five years and so far twenty is the craziest year. I mean, first of all, we have the big virus spreading. People are very fearful about the virus and the economy shutting down. And we also see central banks completely forgetting about all the previous rules and just completely printing money and just doing all of this massive financial stimulus, unlike anything we have ever witnessed before. So we are truly witnessing history in the making. And I think the next few years will bring about a big change to the world. And more specifically, I think that this change will be most noticeable in the economy and potentially in the monetary system as we know it today. And I want to share this quote with you. And some people say that this quote is completely fake. Some people say that it’s just a little bit altered. But I want to share it regardless because it’s a very powerful quote. So supposedly Thomas Jefferson said this. I believe that banking institutions are more dangerous to our liberties than standing armies. If the American people ever allow private banks to control the issue of their currency, first by inflation, then by deflation, the banks and corporations that will grow up around the banks will deprive the people of all property until their children wake up homeless on the continent their fathers conquered. Now, I’m not sure of the full quote is accurate, but I’m pretty sure that the first line here is accurate. I believe that banking institutions are more dangerous to our liberties than standing armies. It is a very, very famous quote. And today. Exactly. This is what’s happening. We are seeing the private banks controlling the issuance of our money or our currency. First, the central banks create money out of thin air. They buy assets from the. From the open market. And then these newly printed currency ends up in the banking system. And the banks can then use this currency to create even more credit. On top of this money, so they can expand the money supply tenfold, 30 fold, even 50 fold in some cases. So through credits, private banks create currency, which is used as money around the world. And that is extremely, extremely dangerous because this means that we have a central authority. Private banks that completely control the money and money is such an important thing for freedom and for control. And the more control someone has over the money than the less freedom everyone else has. And like I said earlier in this video, I think that the next two years will bring about big change. And we’re already seeing people talk about unemployment rates going much, much higher. For example, Goldman Sachs says that the US economy will experience a far deeper slump than previously anticipated. For example, they say here that unemployment will soar to 15 percent by mid-year, up from a previous forecast of 9 percent. They wrote, obviously, these are estimates, but we also see the Federal Reserve. They expect the unemployment rate to hit 32 percent. This is a Fed estimate. So we’re seeing most institutions now talk about high unemployment rates. And I think that it’s quite reasonable to expect that to happen, not only because of the massive debts around the world but also because of the current fears surrounding the virus. So they say that there are nearly 67 million Americans working in jobs that are at a high risk of layoffs. And this is not only true for the US. This is true for countries globally. And according to this Federal Reserve economist, Miguel Ferrer. Castro, he says that, quote, These are very large numbers by historical standards, but this is a rather unique shock that is unlike any other experienced by the U.S. economy. The last one hundred years. And this is a reference to the Great Depression, of course, which happened just over 100 years ago. And remember, guys, for the past two years on my channel, I’ve been talking about the coming recession. The coming crisis will be much worse than the 2008 financial crisis, and it will probably be even worse than the Great Depression. Based on all of the fundamentals, the debt levels, the monetary stimulus and the actions by the central banks, the private banks and all the corporations and even all private individuals just using death and credit as an as in a very, very irresponsible way. And now finally, we’re seeing media covering the threats to the economy that we’re seeing currency. And guys, if you enjoy this video and if you liked my April Fool’s joke about Donald Trump, please go down, leave thumbs up. Let’s see if we can push this video to four thousand likes. Thank you very much for watching this video. And if you haven’t seen my BYB, it’s tutorial links right there right now. And I’ll see you guys tomorrow.

Via https://www.cryptosharks.net/breaking-news-donald-trump-buying-bitcoin/

source https://cryptosharks.weebly.com/blog/breaking-news-donald-trump-buying-bitcoin-april-fools-joke

[scottmapess]

BREAKING NEWS: DONALD TRUMP BUYING BITCOIN!!! | [April fools JOKE]

VIDEO TRANSCRIPT

In this video, major, major news, Donald Trump, the president of the United States, has just changed his mind about Bitcoin, he says I’m buying Bitcoin, the Chinese virus is spreading and the Fed is printing unlimited dollars. So far so good. But if the dollar weakens, we need a backup. He tweeted this tweet just 40 minutes ago and it’s already gone completely viral. I remember the tweet he tweeted just a couple of months ago when he said that he’s not a fan of Bitcoin. Well, times they are changing. And now Donald Trump has completely changed his view and he’s actually officially buying Bitcoin. And other than that, I’m also going to take a look at the big comprise. I want to talk about where the Beacon press is heading in the immediate future. And if you think that that sounds interesting, then I think that you should definitely be. Hello, guys. And welcome to the Moon. My name is Carlin. I’m here to bring you this cryptocurrency video. And let’s take a look at the bit comprise because, well, yesterday I had a lot of comments about potential head and shoulders pattern. So I want to talk about it. But before I talk about the head and shoulders pattern, I just want to quickly talk more about the fact that Donald Trump, the president of the United States, is actually buying bitcoin. And this is, of course, not true. Obviously, this is just a big joke. I was just messing around, guys. And this is not a real tweet from Donald Trump. It’s April Fools, guys. It’s the first of April. So I hope you enjoyed that little joke. And it’s actually really easy to change tweets like this. I can just do this and then inspect and then this will pop up and I can just click here and this will allow me to write anything here, for example, like this and then press enter it. And now we can see how it says don’t buy Bitcoin said so. Sorry, guys, I just thought that was a very funny way to fool you guys. But just to clarify. Donald Trump is not buying bitcoin. At least I don’t think so. And if you liked that little joke, just leave it thumbs up down below. But let’s take a look at the bitcoin price. All right. So yesterday I had many comments about a potential head and shoulders pattern. And ahead and shoulders pattern is, of course, a bearish pattern. It confirms. And the thing about these head and shoulders patterns is that they mean nothing if they don’t break down below the neckline. And if they break the neckline, then that’s when you can make a trade. And in this case, it would be short. So let’s take a look at this. Well, the first problem I see is that here on Coinbase, this shoulder is higher than this head, a shoulder, head and shoulder. Needs to have the shoulders below the head and on Coinbase. We can see that this is actually higher. And that would tell me that maybe this is not a head and shoulders pattern. However, if you go over to buy NANCE, we can see that the head, in this case, is indeed higher than the shoulder. And well, I’m just gonna make the targeted analysis for everyone who wants to know. But personally, I am not really too comfortable with calling this a head and shoulders pattern because of these small in inconsistencies here. But this is how you measure the targets. And if it breaks down below the neckline, then the technical target should be all the way down here at four thousand eight hundred and sixty-two, approximately a little bit, depending on exactly where this breaks down, obviously. And something that could go well with this theory is that we do see the volume go down, as I’ve pointed out previously. And the thing is that when volume goes down while the price is going up, then usually this means that we shouldn’t really trust the current price action. Basically, this means that this uptrend might not be sustainable. So let me just show you exactly what this means. Basically, when we have an option like this, we would like to see the volume remain the same or preferably actually go up as the price is going up. However, if the volume is going down, as the price is going up, then usually this is a sign that this is this move is getting exhausted and we’re running out of buyers basically. And we shouldn’t really trust this price action. And the same goes, of course, for the other way around. Does this mean that Bitcoin is going to break down? Well, no. It doesn’t necessarily mean that, but it does mean that we are in a consolidation phase. And I wouldn’t really trust the current price, actually, because the volume is really coming down. And I would say that as long as the volume continues to go down like this, we won’t see any major trend changes. We will probably stay within this range. We have the resistance up here at approximately six point eight thousand and we have support. I would probably put the sport box over here at somewhere between four points eight and five-point one thousand as long as the volume is low. I would expect the bitcoin price to continue to trade within this range. But like I’ve said so many times when we see declining volume like this, usually, we see this end with a bang, a huge break. And this is exactly what we should be expecting. Big volatility will soon come because right now we’re seeing low volatility, low volume, and some people would call this boring. And I think we could also potentially watch the potential scenario where an ascending triangle might be for me. But I think it’s a little bit early to say that this is an ascending triangle right now. But let’s just keep an eye on this resistance up here at six points eight. And let’s keep an eye on this opportunity support here, which could be this potential neckline of a potential head and shoulders. But like I said, I’m not really too convinced that this is an accurate tt’s shoulders pattern because of the inconsistencies. And if you are an experienced trader and if you’re looking for a platform to trade Bitcoin, these are the platforms that I personally recommend by beat fee mix primates. SBT links down below in the pained comments. And by the way, just a side note, it seems like someone just a few hours ago on crack-in. Bought a thousand bitcoin, and whether this is an institution, a whale or someone who just accidentally bought 1000 thousand Bitcoin like this. I don’t know. Usually, you would see people do these kinds of deals over the counter LTC because this will maybe lower the spread a little bit and you won’t affect the price. So personally, I’m not too sure about exactly what happened here, but you can see this massive volume spike spiking straight up here on cracking and you can see how this candle looks quite amazing actually. But yeah, I don’t have any insider information to share with you guys. I just want to quickly tell you that someone just bought the thousand bitcoin. And by the way, guys, if you are not one of us subscribers yet, please go down below this video. Click subscribe and you can also click lisle Bell. And if you know, click all here, then you will be notified as soon as I upload my next daily video. And over on coin market cap, will you see that toilet paper token has currently taken over the number one spot on core market cap? And I mean we know the bitcoins circulating supply is closing in on 21 million, but the circulating supply of toilet paper talking is out of stock. And next up, I have been alive for twenty-five years and so far twenty is the craziest year. I mean, first of all, we have the big virus spreading. People are very fearful about the virus and the economy shutting down. And we also see central banks completely forgetting about all the previous rules and just completely printing money and just doing all of this massive financial stimulus, unlike anything we have ever witnessed before. So we are truly witnessing history in the making. And I think the next few years will bring about a big change to the world. And more specifically, I think that this change will be most noticeable in the economy and potentially in the monetary system as we know it today. And I want to share this quote with you. And some people say that this quote is completely fake. Some people say that it’s just a little bit altered. But I want to share it regardless because it’s a very powerful quote. So supposedly Thomas Jefferson said this. I believe that banking institutions are more dangerous to our liberties than standing armies. If the American people ever allow private banks to control the issue of their currency, first by inflation, then by deflation, the banks and corporations that will grow up around the banks will deprive the people of all property until their children wake up homeless on the continent their fathers conquered. Now, I’m not sure of the full quote is accurate, but I’m pretty sure that the first line here is accurate. I believe that banking institutions are more dangerous to our liberties than standing armies. It is a very, very famous quote. And today. Exactly. This is what’s happening. We are seeing the private banks controlling the issuance of our money or our currency. First, the central banks create money out of thin air. They buy assets from the. From the open market. And then these newly printed currency ends up in the banking system. And the banks can then use this currency to create even more credit. On top of this money, so they can expand the money supply tenfold, 30 fold, even 50 fold in some cases. So through credits, private banks create currency, which is used as money around the world. And that is extremely, extremely dangerous because this means that we have a central authority. Private banks that completely control the money and money is such an important thing for freedom and for control. And the more control someone has over the money than the less freedom everyone else has. And like I said earlier in this video, I think that the next two years will bring about big change. And we’re already seeing people talk about unemployment rates going much, much higher. For example, Goldman Sachs says that the US economy will experience a far deeper slump than previously anticipated. For example, they say here that unemployment will soar to 15 percent by mid-year, up from a previous forecast of 9 percent. They wrote, obviously, these are estimates, but we also see the Federal Reserve. They expect the unemployment rate to hit 32 percent. This is a Fed estimate. So we’re seeing most institutions now talk about high unemployment rates. And I think that it’s quite reasonable to expect that to happen, not only because of the massive debts around the world but also because of the current fears surrounding the virus. So they say that there are nearly 67 million Americans working in jobs that are at a high risk of layoffs. And this is not only true for the US. This is true for countries globally. And according to this Federal Reserve economist, Miguel Ferrer. Castro, he says that, quote, These are very large numbers by historical standards, but this is a rather unique shock that is unlike any other experienced by the U.S. economy. The last one hundred years. And this is a reference to the Great Depression, of course, which happened just over 100 years ago. And remember, guys, for the past two years on my channel, I’ve been talking about the coming recession. The coming crisis will be much worse than the 2008 financial crisis, and it will probably be even worse than the Great Depression. Based on all of the fundamentals, the debt levels, the monetary stimulus and the actions by the central banks, the private banks and all the corporations and even all private individuals just using death and credit as an as in a very, very irresponsible way. And now finally, we’re seeing media covering the threats to the economy that we’re seeing currency. And guys, if you enjoy this video and if you liked my April Fool’s joke about Donald Trump, please go down, leave thumbs up. Let’s see if we can push this video to four thousand likes. Thank you very much for watching this video. And if you haven’t seen my BYB, it’s tutorial links right there right now. And I’ll see you guys tomorrow.

source https://www.cryptosharks.net/breaking-news-donald-trump-buying-bitcoin/ source https://cryptosharks1.blogspot.com/2020/04/breaking-news-donald-trump-buying.html

[cryptosharks1]

BREAKING NEWS: DONALD TRUMP BUYING BITCOIN!!! | [April fools JOKE]

VIDEO TRANSCRIPT

In this video, major, major news, Donald Trump, the president of the United States, has just changed his mind about Bitcoin, he says I’m buying Bitcoin, the Chinese virus is spreading and the Fed is printing unlimited dollars. So far so good. But if the dollar weakens, we need a backup. He tweeted this tweet just 40 minutes ago and it’s already gone completely viral. I remember the tweet he tweeted just a couple of months ago when he said that he’s not a fan of Bitcoin. Well, times they are changing. And now Donald Trump has completely changed his view and he’s actually officially buying Bitcoin. And other than that, I’m also going to take a look at the big comprise. I want to talk about where the Beacon press is heading in the immediate future. And if you think that that sounds interesting, then I think that you should definitely be. Hello, guys. And welcome to the Moon. My name is Carlin. I’m here to bring you this cryptocurrency video. And let’s take a look at the bit comprise because, well, yesterday I had a lot of comments about potential head and shoulders pattern. So I want to talk about it. But before I talk about the head and shoulders pattern, I just want to quickly talk more about the fact that Donald Trump, the president of the United States, is actually buying bitcoin. And this is, of course, not true. Obviously, this is just a big joke. I was just messing around, guys. And this is not a real tweet from Donald Trump. It’s April Fools, guys. It’s the first of April. So I hope you enjoyed that little joke. And it’s actually really easy to change tweets like this. I can just do this and then inspect and then this will pop up and I can just click here and this will allow me to write anything here, for example, like this and then press enter it. And now we can see how it says don’t buy Bitcoin said so. Sorry, guys, I just thought that was a very funny way to fool you guys. But just to clarify. Donald Trump is not buying bitcoin. At least I don’t think so. And if you liked that little joke, just leave it thumbs up down below. But let’s take a look at the bitcoin price. All right. So yesterday I had many comments about a potential head and shoulders pattern. And ahead and shoulders pattern is, of course, a bearish pattern. It confirms. And the thing about these head and shoulders patterns is that they mean nothing if they don’t break down below the neckline. And if they break the neckline, then that’s when you can make a trade. And in this case, it would be short. So let’s take a look at this. Well, the first problem I see is that here on Coinbase, this shoulder is higher than this head, a shoulder, head and shoulder. Needs to have the shoulders below the head and on Coinbase. We can see that this is actually higher. And that would tell me that maybe this is not a head and shoulders pattern. However, if you go over to buy NANCE, we can see that the head, in this case, is indeed higher than the shoulder. And well, I’m just gonna make the targeted analysis for everyone who wants to know. But personally, I am not really too comfortable with calling this a head and shoulders pattern because of these small in inconsistencies here. But this is how you measure the targets. And if it breaks down below the neckline, then the technical target should be all the way down here at four thousand eight hundred and sixty-two, approximately a little bit, depending on exactly where this breaks down, obviously. And something that could go well with this theory is that we do see the volume go down, as I’ve pointed out previously. And the thing is that when volume goes down while the price is going up, then usually this means that we shouldn’t really trust the current price action. Basically, this means that this uptrend might not be sustainable. So let me just show you exactly what this means. Basically, when we have an option like this, we would like to see the volume remain the same or preferably actually go up as the price is going up. However, if the volume is going down, as the price is going up, then usually this is a sign that this is this move is getting exhausted and we’re running out of buyers basically. And we shouldn’t really trust this price action. And the same goes, of course, for the other way around. Does this mean that Bitcoin is going to break down? Well, no. It doesn’t necessarily mean that, but it does mean that we are in a consolidation phase. And I wouldn’t really trust the current price, actually, because the volume is really coming down. And I would say that as long as the volume continues to go down like this, we won’t see any major trend changes. We will probably stay within this range. We have the resistance up here at approximately six point eight thousand and we have support. I would probably put the sport box over here at somewhere between four points eight and five-point one thousand as long as the volume is low. I would expect the bitcoin price to continue to trade within this range. But like I’ve said so many times when we see declining volume like this, usually, we see this end with a bang, a huge break. And this is exactly what we should be expecting. Big volatility will soon come because right now we’re seeing low volatility, low volume, and some people would call this boring. And I think we could also potentially watch the potential scenario where an ascending triangle might be for me. But I think it’s a little bit early to say that this is an ascending triangle right now. But let’s just keep an eye on this resistance up here at six points eight. And let’s keep an eye on this opportunity support here, which could be this potential neckline of a potential head and shoulders. But like I said, I’m not really too convinced that this is an accurate tt’s shoulders pattern because of the inconsistencies. And if you are an experienced trader and if you’re looking for a platform to trade Bitcoin, these are the platforms that I personally recommend by beat fee mix primates. SBT links down below in the pained comments. And by the way, just a side note, it seems like someone just a few hours ago on crack-in. Bought a thousand bitcoin, and whether this is an institution, a whale or someone who just accidentally bought 1000 thousand Bitcoin like this. I don’t know. Usually, you would see people do these kinds of deals over the counter LTC because this will maybe lower the spread a little bit and you won’t affect the price. So personally, I’m not too sure about exactly what happened here, but you can see this massive volume spike spiking straight up here on cracking and you can see how this candle looks quite amazing actually. But yeah, I don’t have any insider information to share with you guys. I just want to quickly tell you that someone just bought the thousand bitcoin. And by the way, guys, if you are not one of us subscribers yet, please go down below this video. Click subscribe and you can also click lisle Bell. And if you know, click all here, then you will be notified as soon as I upload my next daily video. And over on coin market cap, will you see that toilet paper token has currently taken over the number one spot on core market cap? And I mean we know the bitcoins circulating supply is closing in on 21 million, but the circulating supply of toilet paper talking is out of stock. And next up, I have been alive for twenty-five years and so far twenty is the craziest year. I mean, first of all, we have the big virus spreading. People are very fearful about the virus and the economy shutting down. And we also see central banks completely forgetting about all the previous rules and just completely printing money and just doing all of this massive financial stimulus, unlike anything we have ever witnessed before. So we are truly witnessing history in the making. And I think the next few years will bring about a big change to the world. And more specifically, I think that this change will be most noticeable in the economy and potentially in the monetary system as we know it today. And I want to share this quote with you. And some people say that this quote is completely fake. Some people say that it’s just a little bit altered. But I want to share it regardless because it’s a very powerful quote. So supposedly Thomas Jefferson said this. I believe that banking institutions are more dangerous to our liberties than standing armies. If the American people ever allow private banks to control the issue of their currency, first by inflation, then by deflation, the banks and corporations that will grow up around the banks will deprive the people of all property until their children wake up homeless on the continent their fathers conquered. Now, I’m not sure of the full quote is accurate, but I’m pretty sure that the first line here is accurate. I believe that banking institutions are more dangerous to our liberties than standing armies. It is a very, very famous quote. And today. Exactly. This is what’s happening. We are seeing the private banks controlling the issuance of our money or our currency. First, the central banks create money out of thin air. They buy assets from the. From the open market. And then these newly printed currency ends up in the banking system. And the banks can then use this currency to create even more credit. On top of this money, so they can expand the money supply tenfold, 30 fold, even 50 fold in some cases. So through credits, private banks create currency, which is used as money around the world. And that is extremely, extremely dangerous because this means that we have a central authority. Private banks that completely control the money and money is such an important thing for freedom and for control. And the more control someone has over the money than the less freedom everyone else has. And like I said earlier in this video, I think that the next two years will bring about big change. And we’re already seeing people talk about unemployment rates going much, much higher. For example, Goldman Sachs says that the US economy will experience a far deeper slump than previously anticipated. For example, they say here that unemployment will soar to 15 percent by mid-year, up from a previous forecast of 9 percent. They wrote, obviously, these are estimates, but we also see the Federal Reserve. They expect the unemployment rate to hit 32 percent. This is a Fed estimate. So we’re seeing most institutions now talk about high unemployment rates. And I think that it’s quite reasonable to expect that to happen, not only because of the massive debts around the world but also because of the current fears surrounding the virus. So they say that there are nearly 67 million Americans working in jobs that are at a high risk of layoffs. And this is not only true for the US. This is true for countries globally. And according to this Federal Reserve economist, Miguel Ferrer. Castro, he says that, quote, These are very large numbers by historical standards, but this is a rather unique shock that is unlike any other experienced by the U.S. economy. The last one hundred years. And this is a reference to the Great Depression, of course, which happened just over 100 years ago. And remember, guys, for the past two years on my channel, I’ve been talking about the coming recession. The coming crisis will be much worse than the 2008 financial crisis, and it will probably be even worse than the Great Depression. Based on all of the fundamentals, the debt levels, the monetary stimulus and the actions by the central banks, the private banks and all the corporations and even all private individuals just using death and credit as an as in a very, very irresponsible way. And now finally, we’re seeing media covering the threats to the economy that we’re seeing currency. And guys, if you enjoy this video and if you liked my April Fool’s joke about Donald Trump, please go down, leave thumbs up. Let’s see if we can push this video to four thousand likes. Thank you very much for watching this video. And if you haven’t seen my BYB, it’s tutorial links right there right now. And I’ll see you guys tomorrow.

source https://www.cryptosharks.net/breaking-news-donald-trump-buying-bitcoin/

[kathleenseiber]

Adding a mutation to Ebola could sap its infectious power

Creating mutations in a key protein that helps Ebola escape the body’s defenses can keep the virus from making its hosts sick and activate protective immunity, researchers report.

The mutated virus even works as a vaccine to protect animals from infection with the Ebola virus, researchers say.

The study suggests that VP35, a protein that enables Ebola virus to block early immune responses to infection, is critical for virulence and is a potential drug target.

Zaire ebolavirus, a member of the filovirus family, is a dangerous pathogen that causes outbreaks of severe, often lethal, disease in humans. A 2013-16 epidemic affected more than 28,000 people and resulted in more than 11,000 deaths, with cases spreading from West Africa to Europe and the United States. Outbreaks in the Democratic Republic of the Congo from 2018 to the present have resulted in nearly 1,800 deaths and emphasize the importance of understanding the factors that contribute to the virulence of the virus.

The researchers have been studying VP35 for a while, and in previous work they discovered the protein is fundamental in blocking innate immune responses to Ebola virus infections.

A mutant Ebola virus

In this study, the researchers wanted to determine how VP35 affects Ebola virus disease and host immune responses in animals that most closely resemble human disease. They built mutations into VP35 to create a mutant Ebola virus that was viable and could grow in cell culture. While most current vaccine candidates express a single Ebola virus protein, this mutant virus expresses all of the Ebola virus genes and has the structure of an actual Ebola virus particle.

This mutant virus poses a decreased risk for scientists and shows mutant viruses could be useful for safely studying many Ebola virus functions.

The researchers found that Ebola virus with a mutated VP35 induces immune responses that are strong enough to protect non-human primates from infection with wildtype Ebola virus. VP35 mutant viruses have been studied in other animals, such as mice and guinea pigs, but these animals aren’t the best model for Ebola virus disease.

Administering 1,000 infectious units of wildtype Ebola virus would result in 100% mortality. Because the researchers expected the mutant virus to be less able to cause disease, they gave non-human primates 20,000 infectious units of the mutant virus and the animals didn’t become ill.

Manipulating the immune system

“We think that VP35 is affecting immune responses overall, so after giving this virus that doesn’t cause disease, we thought maybe it will protect animals if you challenge them with the wildtype Ebola virus,” says senior author Christopher Basler, director of the Center for Microbial Pathogenesis and a professor in the Institute for Biomedical Sciences at Georgia State University.

The researchers challenged non-human primates who had previously received the mutant virus with 1,000 infectious units of wildtype Ebola virus. Two of the animals showed no signs of disease. They administered 300,000 infectious units of the mutant virus and challenged the non-human primates with wildtype Ebola virus. The animals developed a robust immune response to the mutant virus and didn’t exhibit the inflammation and mortality found in normal Ebola virus infections.

“They were completely protected. None of them showed any sign of disease to the parental virus,” Basler says. “The big take home message is that we can make an Ebola virus that grows, but if we disable this function, we can now make a virus that is very highly attenuated in the animals. I think that says that the VP35 protein really does manipulate the immune system to allow the virus to grow to cause disease. This function of VP35 would be a good target for therapies if we find a drug that would disable that function.”

In the future, the researchers would like to show that this approach could be used to weaken other members of the filovirus family, such as Marburg virus.

The findings are published in the journal Cell Reports.

Additional coauthors of the study came from the University of Texas Medical Branch; the University of California, Irvine; and Georgia State University.

Funding for the study came from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases.

Source: Georgia State University

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