#mangalaparthi

[net4news]

Telangana: Cinema hall owner's charred body found in his burnt car | Hyderabad News - Net4News

HYDERABAD: A 45-year-old cinema hall owner from Medak was killed by unknown persons at a village in Veldurthi mandal. The assailants burnt the sedan of the victim and his charred body was found in the dickey of the car. On Tuesday morning, residents of Mangalaparthi village in Veldurthi mandal of Medak district saw a burnt car in an open place close to the forest area. They also saw the charred remains of a body in the dickey of the car and alerted the police. Toopran DSP M Kiran Kumar along with a team of police personnel rushed to the spot and verified the details of the completely damaged car. With the help of engine number, police were able to identify that the car belonged to Srinivas, owner of a cinema hall in Medak town. Family members of Srinivas told police that he left home on Monday at 2pm in his Honda City car and did not return. Phone of Srinivas was switched off at 5pm on Monday and police suspect that he was killed by unknown persons after that. The spot where Srnivas’s charred body was found in his car’s dickey, is about 40km away from Medak town. During the preliminary probe, police found out that the victim had an affair with a married woman and her family members might be involved in the murder. “The assailants killed Srinivas and then set ablaze the car with his body in the dickey,” the DSP said. A case was registered under section 302 and 201 of the IPC. Source link Read the full article

[cancersfakianakis1]

Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes.

Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes.

Cancer Biol Ther. 2018 May 03;:1-36

Authors: Rajagopalan P, Patel K, Jain AP, Nanjappa V, Datta KK, Subbannayya T, Mangalaparthi KK, Kumari A, Manoharan M, Karunakaran C, Murugan S, Nair B, Prasad TSK, Mathur PP, Gupta R, Gupta R, Khanna-Gupta A, Califano J, Sidransky D, Gowda H, Chatterjee A

Abstract (250 words) Tobacco usage is a known risk factor associated with development of oral cancer. It is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, molecular alterations induced by tobacco are poorly understood. We therefore sought to investigate the adverse effects of cigarette smoke/chewing tobacco exposure in oral keratinocytes (OKF6/TERT1). OKF6/TERT1 cells acquired oncogenic phenotype after treating with cigarette smoke/chewing tobacco for a period of 8 months. We employed whole exome sequencing (WES) and quantitative proteomics to investigate the molecular alterations in oral keratinocytes chronically exposed to smoke/ chewing tobacco. Exome sequencing revealed distinct mutational spectrum and copy number alterations in smoke/ chewing tobacco treated cells. We also observed differences in proteomic alterations. Proteins downstream of MAPK1 and EGFR were dysregulated in smoke and chewing tobacco exposed cells, respectively. This study can serve as a reference for fundamental damages on oral cells as a consequence of exposure to different forms of tobacco.

PMID: 29723088 [PubMed - as supplied by publisher]

https://ift.tt/2JPGFwH