#liposomal serum

[iberiaskinbrands]

"Sesderma Azelac RU Liposomal Serum: Your Solution for Radiant Skin. This serum combines the power of liposomes with the benefits of azelaic acid to reduce hyperpigmentation and even out your skin tone. Experience the ultimate skin transformation as it fades dark spots, while its antioxidant-rich formula safeguards your skin. Make Sesderma Azelac RU Liposomal Serum a part of your daily routine for a brighter, more radiant complexion."

[ableco]

K-beauty Recovery Reaction! Concentrated Care Guide

Hello! Hello! Hello!

I'm Kim Daehan, the representative of incellderm , the No.1 cosmetics brand in Korea!

Exciting news! Riman Korea has expanded its reach to the United States and Canada! Wow! Applause!! Now, let me guide you on how to become a "Beauty Planner" in the US and Canada!

🌈 INCELLDERM able&co us. Becoming a Beauty Planner!

[must read]How to Join as a Beauty Planner - Step by Step Guide(Click)

🌈 Expansion of Incellderm to the United States and Canada! We are excited to announce that Incellderm is now available in the United States and Canada! Customers in these regions can now experience the benefits of our premium skincare products. ----------------------------------------------------------------------------

"If you are an Incellderm business owner&beauty planner, one thing you must absolutely master is 'Positive Reaction (Skin Regeneration Reaction).' Isn't it the immediate reaction that stands out? The cause of typical positive reactions and detailed coping methods:

Customers experiencing positive reactions show a variety of individual responses, which is why you need to continuously study. I also realized that my knowledge and coping methods regarding positive reactions are insufficient, which could lead to adverse effects on skin management.

Positive Reaction Q&A:

When using Incellderm, various positive reactions appear.

What is a Positive Reaction? Similar to traditional Korean medicine's 'Myeonghyeonbanhaeng' (明顯班現), it refers to a phenomenon where the skin temporarily worsens before improving. Understanding the principle behind positive reactions allows you to enjoy the process as the accumulated epidermal toxins are expelled, and the dermal layer gets replenished. Familiarize yourself with the typical symptoms of positive reactions, their underlying principles, and appropriate coping strategies."

🌈 Itching

Q: Some people experience itching after using Incellderm. Why does this happen?

A: Itching is a clear sign that the dermal layer is undergoing some changes. Incellderm is formulated using the drug delivery system called 'liposome.' The active ingredients of the multi-layered liposome penetrate the skin rapidly, stimulating the capillaries and causing the sensation of itching. This is because new blood vessels are formed, and new skin is generated as the wound heals and the scab falls off. The itching usually occurs in the initial stages but does not last long. However, if the itching persists, it may be necessary to investigate other causes.

Mild Irritation: Itchy sensation accompanied by a feeling like environmental factors are causing it, similar to having hair or insects stuck to the face. ▶ In the basic skincare routine, apply calming gel and serum generously. (Apply the calming gel first and then the serum on top of it.)

Itching Accompanied by Warmth: Caused by strong penetration. ▶ Adjust the application order - Cream → Serum (As the amino acid components in the booster may cause warmth and tingling, reduce the amount of booster used.)

Itching in Trouble or Wounded Areas: Caused by tiny wounds on the skin, often seen in sensitive skin. ▶ Adjust the application area (avoid using on troubled or wounded areas), and to prevent post-inflammatory hyperpigmentation, apply sun gel frequently when going out. Also, maintain excellent hygiene.

Severe Itching: If you experience intense itching that does not subside even when scratched, you should discontinue use. Be cautious about secondary infections caused by scratching with your hands. (Avoid scratching or irritating the skin with your hands as much as possible.) If you have atopic dermatitis, you should seek medical treatment. Please note that the translation provided here is for informational purposes, and it is essential to consult with a healthcare professional or an expert for personalized advice and solutions related to any skin issues.

🌈 Dead Skin Cells (Keratinization)

Q: I used to have few dead skin cells, but after using Incellderm, I am experiencing an increase in dead skin cells. Why is this happening?

A: When using Incellderm, the 'keratinization cycle (the cycle of skin cells being generated and shed)' accelerates. In healthy individuals, the keratinization cycle typically takes around 28 days. However, as one ages and undergoes the process of aging, the keratinization cycle also lengthens. For instance, in their 40s, it could be around 40 days, in their 50s, it could be around 50 days, and so on.

Incellderm activates the cells in the dermal layer, pushing accumulated dead skin cells quickly to the surface and normalizing the keratinization cycle. Therefore, you may notice more dead skin cells than usual.

Additionally, dead skin cells are a process of expelling remnants of synthetic surfactants accumulated in the body. As epidermal toxins and impurities are eliminated, the skin tone becomes clearer and brighter.

Please note that you should distinguish dead skin cells from 'psoriasis.' Psoriasis is a condition where unshed dead skin cells accumulate and form a thick armor-like barrier on the skin, causing it to become hard and rigid. For psoriasis, it is essential to seek medical treatment from a dermatologist.

Dry Dead Skin Cells: This refers to fine, dandruff-like flaking, especially around the jawline. This is caused by nutritional deficiency between dead skin cells.

▶ Avoid artificial peeling using washcloths or exfoliating products. Instead, opt for gentle cleansing and moisturizing, allowing dead skin cells to shed naturally. (Drink plenty of water.)

Oily Dead Skin Cells: This type of dead skin cells appear in the form of clumps due to the combination of sebum and dead skin cells, resembling dirt.

▶ Oily dead skin cells can block pores and cause skin troubles, so make sure to perform deep cleansing frequently.

※ Deep Cleansing Method: Create a rich foam with an active powder cleanser using a foaming tool and apply it to the entire face except the eye area, leaving it on for 2-3 minutes. After some time, when the foam penetrates into the pores, rinse with lukewarm water.

If you have attempted exfoliation:

▶ Refrain from additional peeling as it can worsen the condition and cause further irritation. Instead, opt for regular moisturization using calming gel and stay hydrated.

🌈 Facial Redness, Tingling Sensation

Q: Some people experience redness and occasional tingling sensations on their faces.

A: The development of facial redness and increased redness is often due to skin dehydration. The same applies to tingling sensations. When the skin is dry, especially when it is extremely dry, it means that under a microscope, the lipids between the keratin cells have collapsed, resulting in cracked and flaky skin. In this state, with the lipid layer being disrupted, moisture can easily penetrate, leading to tingling sensations.

This sensation is similar to how steam rises and heat is generated when water is poured onto a dry rice paddy. Usually, tingling sensations and warmth go hand in hand.

Warmth is a typical symptom of the abundant penetration of amino acids. The main ingredients in boosters and serums, amino acids are quickly absorbed into the dermis, causing this sensation. Adjusting the application order is recommended for better results. (Use in the order of sensitivity: Cream -> Serum -> Booster.)

🌈 Red Spots

Q: How should I deal with the appearance of red spots?

A: Red spots often occur due to external factors. If they come and go like hives (urticaria), it might be a positive reaction. However, if a specific area continues to worsen, it is more likely to be dermatitis, and you should seek advice from a dermatologist.

If accompanied by itching: The possibility of contact dermatitis is high (e.g., touching your face with dirty hands). Itching is often caused by skin dehydration.

▶ Avoid dry environments and ensure proper hydration. In the basic skincare routine, using oil mist and calming gel can be helpful. Applying sun gel regularly will provide moisture and soothing benefits to the skin.

Fever and rash: Some people frequently wash their face to cool down, but excessive washing can actually dry out the skin.

▶ Reduce the frequency of washing and focus on moisturizing and soothing. Differentiate between hives and dermatitis, and if it's dermatitis, discontinue the use of products.

Occurrence in specific areas (around the eyes, nose, and mouth): Increased activity of sebaceous glands is the main cause. This symptom appears due to an imbalance in the oil and moisture levels.

▶ Perform deep cleansing and restore the oil-moisture balance in the basic skincare routine, especially using oil mist. For the specific area with red spots, take a break from using boosters, serums, and creams, and instead, apply calming gel to prevent enlarged pores.

(Dab calming gel on a cotton pad and apply it to the specific area.)

🌈 Facial Swelling

Q: My face looks swollen, as if it's puffy. Is this a side effect?

A: It is not a side effect. Incellderm is designed to be absorbed into the skin. However, if a customer using the product has poor peripheral circulation due to diabetes, hypertension, hyperlipidemia, or other reasons, the absorbed cosmetics may become stagnant in the skin, leading to swelling.

If you have been taking medication for diabetes, hypertension, hyperlipidemia, or other conditions for a long time, it is advisable to give yourself a period of one or two months to adapt to the product.

Excessive Use: Swelling can occur due to excessive protein intake.

▶ In particular, avoid excessively using cream, as it can cause issues. (Reduce the amount used.)

Swelling Accompanied by Warmth and Itching: This is common among those who frequent saunas or steam rooms.

▶ Avoid saunas and ensure consistent soothing using cold packs or cold compresses.

Switching from Other Products: Accumulated toxins in the skin might be the cause. Chemical cosmetics often contain harmful substances that can accumulate in the skin. When switching to Incellderm from other cosmetics, these toxins may try to be expelled but get stuck, leading to swelling.

▶ To aid in the smooth elimination of toxins, perform lymph node massage. After showering, mix booster and serum in a ratio of 7:3 and apply it to areas such as behind the ears, armpits, and groin, where lymph nodes are located.

Uneven Swelling: This is also often caused by excessive usage. Excessive cream application can lead to mucous edema.

▶ Maintain consistent soothing while adjusting the amount of product used.

🌈 Hyperpigmentation, Freckles, Skin Tone Changes

Q: After using Incellderm, I've noticed an increase in freckles. Also, why does my skin tone keep fluctuating between looking good and bad?

A: It usually takes about 3 to 6 months for melanin spots that were in the dermis to rise to the epidermis. So, it's not possible for freckles to appear immediately after using Incellderm.

The melanocytes that create freckles are located in the innermost layer of the epidermis called the basal layer. What we see as freckles is actually melanocytes filled up to the stratum corneum layer. When you start using Incellderm, the skin condition improves rapidly, and the melanocytes in the basal layer are pushed up to the stratum corneum, so it may seem like freckles are increasing for a while.

However, with continuous use of the product, freckles will gradually become lighter and clearer.

During the initial 7 to 15 days of product usage, the skin tone becomes clearer due to various beneficial cell growth factors, and after about 15 days, the skin tone may fluctuate between good and bad.

This is because the skin, as a tissue composed of cells, promotes cell division when stimulated by various growth factors, much like when it was young. The promotion of cell division means that what was inside the skin is pushed up, which also means that more dead skin cells are produced.

Cells born in the skin rise to the surface and stay there in the form of dead skin cells until they eventually fall off. This process is called turnover, and the normal turnover cycle of healthy skin is about 28 days. Incellderm promotes this skin regeneration process, and the time it becomes visible to the naked eye is around 7 to 15 days after using the product. This is when you might notice your skin tone fluctuating between looking good and bad.

External factors such as pregnancy, genetics, medication use, hormonal changes, and weakened immunity can also cause these phenomena.

If you have undergone treatments for removing freckles or freckle-like pigmentation, the condition you're experiencing might be due to dermal freckles surfacing, and they can reappear at any time.

Neglecting sun protection: Many people tend to focus only on using boosters, serums, and creams and overlook the use of sun gel when going outside (e.g., applying only cream before going out). Proper sun protection is crucial to prevent hyperpigmentation and freckles.

Temporary darkening or dullness of the skin: This is a natural fluctuation in the brightness of the skin and will improve on its own over time.

🌈 Tightness, Dryness

Q: When I use the product, I feel tightness and dryness. What is the reason behind this?

A: The skin is a very thin tissue and cannot distinguish well between the sensation of collagen being formed, which causes tightness, and the dry feeling on the surface due to the dry stratum corneum layer.

When spider-web-like collagen is produced and released, it resists gravity and lifts the skin back up, resulting in a feeling of tightness and increased skin elasticity.

In the case of Incellderm, both of these effects occur:

Inner Tightness: Enjoy this sensation as it is the lifting effect due to collagen production. However, be cautious not to use the product excessively due to misunderstanding.

Surface Dryness (Epidermal Dryness): Proper cleansing and sufficient moisturization are necessary. If the tightness is severe, applying a generous amount of calming gel like a pack before going to bed can help alleviate the sensation.

Insufficient Moisturization: Surprisingly, many people don't drink enough water during the day. Make sure to drink around 2 liters of water daily. Sufficient moisturization enhances the absorption of boosters, serums, and creams. You can think of it like a dry sponge that repels water versus a slightly damp sponge that absorbs more water. Improving lifestyle habits is also important. Consuming salty and carbonated foods, as well as coffee, can deplete the body's moisture.

Dermis Cracking: Although rare, if your skin cracks and bleeding occurs, immediately discontinue the use of the product and seek advice from a dermatologist.

Remember that finding the right balance in product usage and maintaining good skincare habits can help address the tightness and dryness issues effectively.

🌈 Expression Lines

Q: The product I'm using has dual functionality for whitening and wrinkle improvement, but why do I feel like I have more wrinkles now?

A: The cause of wrinkles is the aging of collagen tissues in the dermis, which makes the boundary between the epidermis and dermis uneven. When collagen in the dermis starts to be produced and released like spider webs, the boundary between the epidermis and dermis becomes uneven for a while, resulting in the appearance of wrinkles that weren't there before. However, the wrinkles caused by the product's use do not last long. As wrinkles appear and disappear repeatedly, the dermis gradually fills up, and the boundary between the epidermis and dermis becomes flatter. As a result, the skin's surface becomes smoother, leading to the ultimate wrinkle improvement effect.

Expression lines are wrinkles that occur when unabsorbed ceramides (*ceramides are ingredients most similar to skin cells, and Incellderm products are manufactured using the method of encapsulating active ingredients with ceramides to deliver them to the dermis). This phenomenon can appear as if a vinyl wrap is applied to the skin. This occurs when the product is used excessively, so reducing the amount used can help.

Especially when you apply too much cream around the eye area, it can irritate the delicate skin around the eyes and lead to the appearance of expression lines. To address these expression lines, reduce the amount used and make sure to thoroughly moisturize the area.

By maintaining the proper usage of the product and paying attention to how much is applied, you can achieve the desired results without experiencing any unwanted effects on your skin.

🌈 Troubles (Skin Issues)

Q: I have developed pimples. What should I do?

A: Pimples and other skin troubles can occur from time to time. In particular, women may experience recurring pimples in relation to their menstrual cycles.

One of the causes of skin troubles is the accumulation of epidermal toxins. Conventional cosmetics use a mixture of water and oil with synthetic surfactants, which may contain harmful epidermal toxins. People who have used chemical cosmetics in the past may have a higher likelihood of having epidermal toxins accumulated in their skin. When using Incellderm products, as the overall condition of the skin improves and the epidermal toxins are eliminated from the skin, a reaction like the improvement of pimples can occur. To minimize such reactions, it is advisable to start using the product with a small amount and gradually increase it to allow for an adaptation period.

Pustules (Pus-filled pimples): They can occur from overusing the product. This is caused by insufficient absorption of protein, leading to the formation of skin troubles. Adjust the usage amount and pay attention to moisturizing. The primary cause of pustules is lack of moisture. When there is not enough moisture, pimples are more likely to form. If pimples have already appeared, apply a calming gel pack to the affected area. (Dip a cotton pad in calming gel and place it on the affected area.)

Comedones (Blackheads and whiteheads): These occur when sebum becomes trapped under the layer of dead skin cells in the pores. Use deep cleansing at least once or twice a week to remove dead skin cells.

Vesicles (Inflammatory bumps): If skin troubles are accompanied by vesicles, it is not a reaction caused by using Incellderm products. These are caused by internal factors such as herpes virus or shingles. In such cases, immediately stop using the product and seek medical treatment.

Prolonged use of a specific brand: Skin troubles can occur due to the residual synthetic surfactants from the prolonged use of conventional chemical cosmetics.

🌈 Other Improvement Reactions

Q: Could it be flat warts?

A: It is easy to confuse flat warts with comedones (blackheads and whiteheads). Flat warts are caused by human papillomavirus (HPV) and are often seen when the immune system is weakened. Flat warts are highly contagious, so avoid squeezing them and seek dermatological treatment promptly.

Q: My eyes feel irritated, teary, and uncomfortable, as if there's something in my eyes.

A: Incellderm products are designed to penetrate deep into the skin, so as you age, around your 40s to 50s, your eyes may feel uncomfortable for a while. People with dry eye syndrome may experience this discomfort. The beneficial ingredients in the product help improve the function of the tear glands, leading to increased tear production. With continuous use and adaptation, your eyes should no longer feel uncomfortable.

Q: I haven't lost weight, but people say my face looks smaller, as if I've lost weight.

A: As you age, the skin inside the face may become less dense, and due to gravity, the skin can start to sag. However, with Incellderm products, the skin inside becomes gradually filled, and with consistent use for about 6 months to 1 year, the skin is lifted, resulting in a balanced facial line and making your face appear smaller.

🌈 Expansion of Incellderm to the United States and Canada!

We are excited to announce that Incellderm is now available in the United States and Canada! Customers in these regions can now experience the benefits of our premium skincare products. 🌈 INCELLDERM able&co us. Becoming a Beauty Planner!

[must read]How to Join as a Beauty Planner - Step by Step Guide(Click) For any necessary guides or support in the North American market, I'll update you through Discord! Check out the link tree for community updates! (CLICK)

Referring Beauty Planner ID: 2046299575 * "KIM DAEHAN" Global REFERRAL: 09443 * "안정수"

[happyzyx]

Liposome Advanced Repair Eye Serum: Interview with 张艺兴 DECORTÉ Global Skincare Ambassador

[metastatblog]

Anti-aging EGF market Analysis, Size, Share, Growth, Trends, and Forecasts by 2031

The Anti-aging EGF Market, a dynamic and transformative sector within the beauty and skincare industry, presents a captivating landscape of innovations, trends, and consumer demands. This market revolves around EGF, or Epidermal Growth Factor, a remarkable protein with extraordinary properties that have captured the attention of individuals seeking to reverse the effects of aging. 

𝐆𝐞𝐭 𝐚 𝐅𝐫𝐞𝐞 𝐒𝐚𝐦𝐩𝐥𝐞 𝐑𝐞𝐩𝐨𝐫𝐭:https://www.metastatinsight.com/request-sample/2449

Top Companies

BIOEFFECT

LipoTrue S.L.

Skin Actives Scientific LLC

Spec-Chem Industry Inc.

TUNEMAKERS

DHC Corporation

C. Biotec Inc.

Kate Ryan Skincare. LLC

Bio-Vitae

Overt Skincare

Gold Biotechnology, Inc. (GoldBio)

Cell Guidance Systems

Peptide Institute, Inc.

Thermo Fisher Scientific Inc.

Prospec-Tany Technogene Ltd.

EGF, discovered by renowned scientists Stanley Cohen and Rita Levi-Montalcini in the 1980s, plays a central role in regulating cell growth, differentiation, and tissue repair, making it a powerful ally in the quest for youthful, rejuvenated skin.

𝐄𝐱𝐩𝐥𝐨𝐫𝐞 𝐭𝐡𝐞 𝐅𝐮𝐥𝐥 𝐑𝐞𝐩𝐨𝐫𝐭:@https://www.metastatinsight.com/report/anti-aging-egf-market/2449

At the core of the Anti-aging EGF Market lies a multifaceted array of products, each designed to harness the potential of EGF and deliver its benefits to consumers. From serums and creams to specialized treatments, the market offers a diverse range of options for those looking to enhance the vitality and elasticity of their skin. These products often boast scientific breakthroughs and state-of-the-art formulations, promising visible results in reducing wrinkles, improving skin texture, and restoring a youthful complexion.

Furthermore, the Anti-aging EGF Market is deeply intertwined with advancements in biotechnology and skincare research. The development of advanced delivery systems, such as nanotechnology and liposomal encapsulation, has enabled EGF to penetrate the skin more effectively, maximizing its regenerative effects. This synergy between science and beauty has become a driving force behind the market's growth.

In recent years, the demand for natural and sustainable beauty products has also permeated the Anti-aging EGF Market. As consumers increasingly seek eco-friendly and cruelty-free options, manufacturers have responded with EGF-based products that align with these values. This shift reflects the broader trend in the beauty industry toward a more ethical and environmentally responsible approach.

In addition to technological advancements and ethical considerations, the Anti-aging EGF Market is characterized by a constant pursuit of personalization and individualization. As each person's skin is unique, a one-size-fits-all solution is no longer sufficient. The market now offers personalized skincare regimens, often incorporating EGF, tailored to an individual's specific needs and concerns. This customization enables consumers to address their unique aging challenges effectively.

Global Anti-aging EGF market is estimated to reach $199.0 Million by 2030; growing at a CAGR of 5.9% from 2023 to 2030.

Contact Us:   

inquiry@metastatinsight.com

+1 214 613 5758

[helen0086]

Therapeutic Effect of Phycocyanin on Skin Injury in Mice

Abstract: In order to investigate the therapeutic effect of CPC on skin injury in mice, ICR mice were divided into five treatment groups, namely, normal control group (Con), model group (Mod), blank dressing group (BD), alginate dressing group (CPC TDD), and alginate dressing + alginate intraperitoneal injection group (CPC + ip.), and then scalded in a scald test. The results showed that the CPC TDD group and CPC+ip. group had the shortest wound healing time, reduced the serum malondialdehyde (MDA) content, increased the superoxide dismutase (SOD) content, and lowered the serum levels of inflammatory factors TNF-α and IL-6. Phycocyanin enhances the antioxidant capacity of the body and reduces the level of inflammatory factors, thus promoting the healing of skin injury.

With the increasing frequency of China's marine activities and the complexity of the surrounding marine situation, the incidence of burns combined with marine accidents is increasing [1, 2]. Seawater has special physicochemical properties such as hypertonicity, alkalinity, low temperature, and bacteria, etc. Burns combined with seawater immersion will cause hypertonicity, electrolyte disorders, hemodynamic disorders, and microcirculatory disorders of traumatic tissues; and the secondary injuries are more serious, which can easily lead to multiple organ failures, such as acute lung injuries [3].

C-phycocyanin (CPC) is a blue powder that is soluble in water and insoluble in lipids. C-phycocyanin is a blue powder, water-soluble and insoluble in lipids. The molecule consists of an open-chain tetrapyrrole compound and a deaccessorized protein bound by a thioether bond [4]. Spirulina has a relatively high phycocyanin production rate and phycocyanin content per unit of biomass [5]. In pharmacological studies, CPC has been used in the treatment of oxidative stress-induced diseases and as a powerful anti-inflammatory agent [6-8] and antioxidant [9-11]. In recent years, studies on CPC have mainly focused on the pigment phycocyanin, fluorescence of CPC, antioxidant and anticancer activities of CPC, as well as the modification and stability of CPC [12]. At present, it has been reported at home and abroad that phycocyanin has a strong wound healing effect with a high safety factor.

Madhyastha et al [13] demonstrated that CPC accelerated wound healing by inducing fibroblast proliferation through the cell cycle-dependent kinases CDK1 and CDK2 on the one hand, and promoting cell migration to the wound on the other, and subsequently prepared biodegradable CPC scaffolds [14], which were applied to accelerate the first phase of wound healing in mice with skin injuries.In a study by Manconi et al [15], conventional phospholipid microcapsules were found to increase the anti-inflammatory activity of CPC in mice in a dose-dependent relationship. Manconi et al. [15] found that conventional phospholipid microcapsules were able to increase the anti-inflammatory activity of CPC in mice in a dose-dependent manner, whereas liposomes produced the same anti-inflammatory response as the free protein at only 1/2 the dose of CPC; Madhyastha et al. [16] synthesized silver nanoparticles (AgCPCNPs), a low toxicity dermal wound repair material, by using alginate cyanoblue (CPC) as a raw material, which has the advantage of CPC as a wound repair material, and has the advantage of CPC as a wound repair material. Madhyastha et al. [16] synthesized silver nanoparticles (AgCPCNPs), a less toxic material for dermal wound repair using alginin (CPC) as a raw material, which has the dual advantages of CPC as a wound repair agent and Ag nanometal as an antibacterial agent.

In the present study, alginate was prepared as a dressing and its therapeutic effects, such as anti-inflammatory, antioxidant, and accelerated wound healing, were investigated in a mouse skin injury test.

1 Materials and Methods

1.1 Materials

1.1.1 Laboratory animals: 90 male ICR mice (Certificate No. 20201130Abzz0105999214 SPF grade) with intact skin and weighing 20-25 g. The 60Co sterilized feed and sterilized bedding used to feed the mice were supplied by the Zhejiang Laboratory Animal Center.

1.1.2 Instruments YP1002N electronic balance, BT125D analytical balance (Shanghai Minqiao Precision Scientific Instrument Co., Ltd.), UPT-II-60L floor-standing ultrapure water machine (Shanghai Sike Instrument Co., Ltd.), CF16RN high-speed tabletop freezing centrifuge (HITA ⁃ CHI Company, Japan), DK-S24 electrothermal thermostatic water bath (Shanghai Senxin Laboratory Instrument Co., Ltd.), DHG-9140A blast drying oven (Shanghai Jinghong Experimental Equipment Co., Ltd.). Ltd.), DHG-9140A blower drying oven (Shanghai Jinghong Experimental Equipment Co., Ltd.).

1.1.3 Reagents    

PVA-124, CPC, ethanol, ethyl hydroxyphenyl ester, propylene glycol, nitrogen ketone, chloral hydrate, sodium sulfide, sodium chloride, magnesium chloride, magnesium sulfate, calcium chloride, sodium bromide, sodium bicarbonate and potassium chloride were purchased from Sinopharm Chemical Reagent Corporation; superoxide dismutase (SOD) and malondialdehyde (MDA) kits were purchased from Shanghai Biyuntian Bio-Technology Co; Interleukin-6 (IL-6) kit and tumor necrosis factor (TNF-α) kit were purchased from Abbott (Shanghai) Trading Co.

1.2 Methodology

1.2.1 Preparation of alginate dressing Weigh 0.9 g PVA-124 and 0.03 g hydroxyphenethyl ester added to pure water, placed in a 90 ℃ water bath to dissolve for 24 h, colloid cooling standby . Weigh 0.03 g CPC to join the colloid dissolved, and then add 5 mL of anhydrous ethanol, 0.3 mL of 1% propylene glycol solution and 0.3 mL of 1% azetidone solution mixed homogeneously, add ddH2O volumizing to 30 mL standby.

1.2.2 Sea water conditions    

The seawater used was prepared according to the formula of the Third Institute of Oceanography of the State Oceanic Administration (Table 1), and the main components and contents were close to those of the seawater off the southeast coast of China, with a pH of 8.2, a relative density of 1.05, an osmotic pressure of 1,300 mmol/L, and a 0.22 μm filtration membrane, and then placed in 4 ℃ for storage.

Table 1 Seawater formulations

name (of a thing)

Content//g/L

NaCl

26.518

MgCl2

2.447

MgSO4

3.305

CaCl2

1.141

NaBr

0.083

NaHCO3

0.202

KCl

0.725

1.2.3 Preparation of animal models for grouping and drug administration

(1) Grouping of mice and administration of drugs. Mice were randomly divided into Control group (Con), Model group (Mod), Blank dressing group (BD), C-phycocyanin transdermal drug delivery group (CPC TDD), CPC transdermal drug delivery+CPC in⁃ traperit injection group (CPC TDD), and CPC transdermal drug delivery+CPC in⁃ traperit injection group (CPC TDD). BD, Blank dressing group (BD), C-phycocyanin transdermal drug delivery group (CPC TDD), CPC transdermal drug delivery + CPC in⁃ traperitoneal injection group (CPC+ip.). The drug delivery methods are shown in Table 2.

Table 2 Grouping of animals and administration of drugs

Grouping Administration

Con Mod BD

CPC TDD

CPC+ip.

leave sth. untouched

Apply sterile saline evenly to the wound, 12 h 1 time

A blank dressing was evenly applied to the wound, with a drug thickness of 0.1 cm, once every 12 h.

Apply a prescription phycocyanin dressing to the wound uniformly, with a drug thickness of 0.1 cm.

12 h 1 time

A phycocyanin dressing was applied uniformly to the wound with a drug thickness of 0.1 cm.

12 h once; intraperitoneal injection of phycocyanin at a concentration of 200 mg/kg, 24 h once

Scald test .

Thirty mice were fed and watered ad libitum and housed under standard environmental conditions (24±2°C, 40%~60% humidity, and a 12-h light-dark cycle) for 1 week after acclimatization.

②Dehairing: 8 g NaS and 100 mL ddH2O were used to make dehairing agent, mice were dehaired and left for 24 h to recover naturally. (iii) Modeling: Each mouse was anesthetized by intraperitoneal injection of 10% chloral hydrate solution (0.04 mL/10 g). Then a preheated round weight [(95±2)°C] with a diameter of 1.5 cm was placed on the hair removal area on the back of the mice with a camera clamped to cause scalding for 10 s, resulting in scalding of the skin of the mice, and the scalding area was kept consistent in each mouse.

Post-scald immersion in seawater. The scald test was repeated, and the scalded mice were immediately tied and immersed in the prepared seawater for 1 h. After the mice were recovered, the wounds were rinsed with saline.

4) Post-traumatic seawater immersion test . The dehairing area of mice was sterilized with 75% ethanol solution, and a 1 cm × 1 cm square wound was cut into the dorsal spine, deep enough to reach the mucous layer of the skin. The mice were immersed in seawater for 1 h after traumatization, and after the mice were recovered from the water, the seawater on the body surface was wiped dry, and the wounds were rinsed with physiological saline.

1.2.4 Indicator testing

1) Body weight . The body weight of the mice was examined during the wound healing process, and the trend of body weight change was observed.

2) Wound healing time. Record the wound healing time of each group of mice from the time of wound infliction to the time when the wound surface starts to crust and the wound is basically healed.

(3) Changes in wound area and wound healing rate . The wound area was recorded on days 3, 7, and 14, and the wound healing rate was calculated. Wound healing rate = [(initial wound area - area on the day of measurement)/initial wound area] × 100%.

(4) Histological analysis. On the 3rd, 7th and 14th days after wounding, mice were anesthetized, and tissue specimens of 1 cm×1 cm in size and not more than 3 mm in thickness were cut from the traumatized surfaces, and HE staining was used to observe the histological changes of the skin and evaluate the pathological changes.

5) Determine the serum levels of inflammatory factors and antioxidant factors . TNF-α, IL-6, MDA and SOD levels in serum were determined.

1.2.5 Data analysis    

SPSS13.0 statistical analysis software was used to analyze the data of each group statistically, and the data were expressed as mean ± standard deviation (x ± S). The t-test was used for multiple comparisons within groups, and then the Newman-Coyles test was used. p<0.05, the difference between the comparison groups was significant.

2 Results and analysis

2.1 Scald test results

2. 1. 1 Molding effect The molding effect is shown in Figure 1.

2. 1.2 Effects of alginate on body weight of mice    

As shown in Fig. 2, the weight of mice in the Con group increased steadily, and except for the Con group, the weight of mice in other treatment groups had a tendency of decreasing and then increasing at the beginning of the treatment period; the weight of the CPC+ip. group recovered the most quickly, followed by the CPC TDD group; the recovery of the CPC+ip. group was close to that of the Con group at the end of the scalded period. The results showed that phycocyanin treatment had the effect of promoting the recovery of body weight in mice due to the symptoms of dehydration, decreased appetite and inflammation at the initial stage of scald injury.

2. 1.3 Effects of algal blue proteins on changes in wound area    

From Figures 3 and 4, it can be seen that the Mod group had the slowest wound healing speed, and the wound was still not completely healed at day 14, while the BD group was similar to the Mod group. Compared with the Mod group, the CPC TDD group had the fastest healing speed and the wound was basically healed at day 14. Compared with the other groups, the CPC+ip. group had the fastest wound healing rate, and the wound was completely healed and the body hair began to recover at day 14. The results showed that after the scalded back of mice, the tissue fluid exuded a lot, and then dried and hardened to form a scab. Blank dressings had little effect on skin healing, while phycocyanin promoted skin healing and was more effective when supplemented with intraperitoneal injections.

1.4 Results of histological changes    

As shown in Figure 5, during the healing process, a large number of platelets aggregated early to form clots, which gradually hardened to form scabs. The capillary permeability of the wound edge increased, and a large number of inflammatory cells (lymphocytes and mononuclear macrophages) exuded, mainly concentrated around the wound edge. 3 d, the epithelial cells of each group were obviously destroyed, and most of the epithelial tissue was detached; 7 d, there were already more healed and about to be healed parts in the CPC TDD group and the CPC+ip. group; 14 d, the epithelial cells were arranged neatly and continuously, with good coloration of the epithelial cells in the CPC TDD and the CPC+ip. group, and the dermal tissues and accessory structures were clear. In the CPC TDD and CPC+ip. groups, at 14 d, the epidermal cells were arranged neatly and continuously, the epithelial cells were well colored, the dermal tissues and appendages were clear and intact, and the collagen cells of the dermis were arranged neatly. The results showed that phycocyanin could promote the structural repair of scalded wounds and protect the integrity of skin tissues and cell structures.

2. 1.5 Effect of algin on serum MDA and SOD levels in scalded mice    

As shown in Figure 6, compared with the Mod group, the serum MDA content of the CPC+ip. group decreased significantly and the SOD content increased significantly (P<0.05), while the serum MDA content of the CPC TDD group also decreased and the SOD content increased, but not significantly. The results showed that phycocyanin could promote the expression of SOD and reduce the content of MDA to improve the antioxidant ability of mice, thus promoting wound healing.

1.6 Effect of algin on TNF-α and IL-6 in the serum of scalded mice   

As shown in Figure 7, the serum levels of TNF-α and IL-6 were increased in the Mod group compared to the Con group. Compared with the Con group, the serum levels of TNF-α and IL-6 in the CPC+ip. group were significantly reduced (P<0.05). Thus, phycocyanin could reduce the inflammatory response of scalded mice by down-regulating the expression of inflammatory factors.

2.2 Results of seawater immersion test after burns

2.2.1 Modeling Effect The modeling effect is shown in Figure 8.

2.2.2 Effects of alginate on body weight of mice    

As shown in Fig. 9, the body weight of Con group basically showed a stable growth trend, the body weight of Mod, BD and CPC TDD groups firstly decreased and then increased, and the body weight of CPC+ip. group showed an increasing trend, which was obviously higher than that of other treatment groups. The results showed that phycocyanin could promote the recovery of body weight in mice, and the effect was better when supplemented with intraperitoneal injection.

2.2.3 Effect of alginate on changes in wound area    

As shown in Figures 10 and 11, the wounds of the Mod and BD groups were still not healed at 14 d. The wound healing rate was lower than that of the other two groups, and there were still scabs. CPC TDD and CPC+ip. mice took less time to lose scabs than the Mod and Con groups, and the CPC+ip. group took the shortest time, and the CPC+ip. group had almost completely healed their wounds on the 14th day. The results showed that phycocyanin could promote the healing of injured skin in mice, and the best effect was achieved by intraperitoneal injection.

2.2.4 Results of histologic changes    

As shown in Figure 12, 3 days after the injury, the traumatic tissues of mice in all treatment groups showed varying degrees of inflammatory cell infiltration, loose submucosa, and destruction of hair follicles, and the degree of inflammation in the traumatic tissues of the Mod and BD groups was significantly higher than that in the CPC+ip. and CPC TDD groups, with severe detachment of the epithelial cells from the mucous membranes, and the arrangement of the cells was sparse and irregular. On day 7, the degree of inflammation in the CPC+ip. group was significantly reduced, hair follicles increased, and epidermal cells were structurally intact and proliferated vigorously, whereas the epidermal cells in the other treatment groups were still sparse and irregularly arranged. On day 14, the wounds of mice in the CPC+ip. and CPC TDD groups were close to healing, and the cells were structurally intact and well organized. On day 21, the epidermal cells of the wounds of mice in all treatment groups were tightly arranged and well organized.

2.2.5 Effects of alginate on MDA and SOD contents in the blood serum of sea water immersed mice after scald injury As shown in Fig. 13, compared with the Mod group, the SOD contents of the CPC TDD group and the CPC+ip. group increased, the MDA contents decreased, and there was a significant difference in the CPC+ip. group (P<0.05). The results showed that phycocyanin could enhance the antioxidant stress response in vivo, and the effect was better when supplemented with intraperitoneal injection.

2.2.6 Effect of algin on TNF-α and IL-6 in the serum of scalded mice As shown in Fig. 14, compared with the Con group, the serum levels of TNF-α and IL-6 in the Mod group increased. Compared with the Mod group, the serum levels of TNF-α and IL-6 in the CPCTDD and CPC+ip. groups were decreased, and the serum levels of TNF-α and IL-6 in the CPC+ip. group were significantly lower than those in the Mod group (P<0.05). The results indicated that phycocyanin could down-regulate the expression of inflammatory factors.

2.3 Post-traumatic sea water immersion test

2.3.1 Molding effect The molding effect is shown in Fig. 15.

2.3.2 Changes in body weight of mice As shown in Fig. 16, the body weight of the Con group showed a steady increase, while the body weights of mice in the CPC TDD group and the CPC+ip. group showed a plateau within 5 days, after which the body weights began to increase rapidly.

2.3.3 Wound healing time As shown in Figures 17 and 18, the wounds of the Mod and BD groups were still not healed at 14 d. The wound healing rate was lower than that of the other two groups, and the scabs were detached from all groups.The time taken to detach the scabs of the mice in the CPC TDD and CPC+ip. groups was lower than that of the Mod and Con groups, and there was a significant difference between the CPC+ip. group and the Mod group (P<0.05). There was a significant difference between the CPC+ip. group and the Mod group (P<0.05). The wounds of the CPC+ip. group were basically healed at the 14th day. The results indicated that phycocyanin could promote the healing of injured skin in mice.

2.3.4 Histological changes As can be seen in Figure 19, at day 7, the Mod group had oedema, massive inflammatory cell infiltration, necrosis of epidermal cells, and an incomplete traumatic surface, while the CPC TDD and CPC+ip groups had reduced inflammatory cell infiltration and the epidermis was gradually recovered. On the 14th day, in Mod group, part of the wound surface was necrotic, the epidermis was still incomplete, there were scars and neoplastic tissues appeared. in CPC TDD group and CPC+ip. group, the epidermis was thickened and the wound surface was intact, the structure of the skin was clear, and the formation of granulation tissues could be seen.

2.3.5 Effects of alginate on MDA and SOD in the blood serum of sea water immersed mice after scald injury As shown in Fig. 20, compared with the Con group, the serum SOD content of the Mod group decreased and the MDA content increased. Compared with the MOD group, the SOD content in the CPC TDD group and CPC+ip. group increased and the MDA content decreased, with a significant difference in the CPC+ip. group (P < 0.05). The results showed that phycocyanin could enhance the antioxidant stress response in vivo, and the effect of intraperitoneal injection was better.

2.3.6 Effects of algin on the serum levels of TNF-α and IL-6 in scalded mice As shown in Fig. 21, compared with the Con group, the serum levels of TNF-α and IL-6 in the Mod group increased. Compared with the Mod group, the TNF-α and IL-6 levels decreased in the CPC TDD and CPC+ip. groups. The serum levels of TNF-α and IL-6 in the CPC+ip. group were significantly lower than those in the Mod group (P<0.05). The results indicated that phycocyanin could down-regulate the expression of inflammatory factors.

3 Summary and discussion

SOD can effectively scavenge oxidized free radicals, maintain the balance of free radicals in the body, and protect the tissues from oxidative damage. low SOD content will lead to a large accumulation of oxygen free radicals, which will lead to lipid peroxidation, generating a large amount of lipid peroxides (MDA), and damaging the body. Liu Qi et al. [17] found that alginate had a preventive effect on the oxidative system damage model induced by X-ray radiation in mice. Compared with the model group, the serum and liver tissue of the alginate prevention group showed an increase in SOD content, a decrease in MDA content, and an increase in ROS and GSH-PX content in the liver tissue, indicating that alginate can protect the oxidative system in the body and improve the body's antioxidant ability. In the present study, the SOD content increased and MDA content decreased in mice using algin dressing, and the effect of supplementing with intraperitoneal injection of algin was more significant.

TNF-α induces cytokines such as IL-1, IL-10, IFN-γ and other cytokines to participate in the inflammatory response in injured mice.The higher levels of IL-6 and TNF-α indicate a more intense inflammatory response and slower wound healing in mice.Grover et al.[18] found that phycocyanin could inhibit the production of inflammatory cytokines (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-12, IL-13, IFN-c, TNF-a), thus increasing the immunity of the organism, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-12, IL-13, IFN-c, TNF-a), thus increasing the immunity of the body. The present study demonstrated that CPC could reduce the synthesis of IL-6 and TNF-a in the serum of mouse skin injury model, and reduce the inflammatory response of mice, thus promoting the healing of mouse skin and achieving therapeutic effects.

Algae blue protein also has functional activities such as anti-tumor, anti-fibrosis, and enhancement of immunity [19]. The study of Sun Yingxin [20] found that algal blue protein could reduce paraquat-induced pulmonary fibrosis in rats, lower the MDA content in serum and lung tissue, increase the content of SOD antioxidant enzyme, inhibit the activity of TNF-α and lower the level of TGF-β1. Zhai Shixiang [21] found that phycocyanin could alleviate LPS-induced hepatic stellate cell fibrosis and CCL4-induced hepatic fibrosis in rats, and found that phycocyanin could increase the abundance of intestinal flora with anti-inflammatory activity in rats. The study of Han Minmin [22] found that phycocyanin significantly inhibited the growth of eight types of tumor cells, including human hepatocellular carcinoma cells and human pancreatic cancer cells, and was able to promote the development of immune organs and enhance immunity in mice. Zhang Xin et al. [23] found that phycocyanin and its α and β subunits significantly inhibited the growth of human lung adenocarcinoma SPC-A-1 cells, and the cell survival rate was inversely proportional to the concentration. Chu et al. [24] found that C-alginin induced apoptosis and inhibited the proliferation of breast cancer cells, and the main mechanism may be related to the activation of p38MAPK and JNK signaling.

References:

［ 1］ Xia Zhaofan, Ma Bing. A few thoughts on the treatment of naval war trauma under modern war conditions [J]. PLA Medical Journal, 2016, 41(12):973-976.

[2] Luo Dan, Wang Yina, Wu Jianxin, et al. Mastery of key operational skills for self-rescue and mutual rescue of soldiers with marine injuries［J］. PLA Nursing Journal, 2020, 37(7):66-68.

[3] Ma Jun, Discussion on the mechanism of acute lung injury after burns combined with seawater immersion［D］. Guangzhou: Southern Medical University, 2017.

［4］LIU L N, CHEN X L, ZHANG Y Z, et al. Characterization, struc⁃ ture and function of linker polypeptides in phycobilisomes of cyano ⁃ bacteria and red algae: an overview［J］. : An overview［J］. BBA-bioenergetics, 2005, 1708(2):133-142.

[5] Fang Hui. Rapid Detection of Cyanobacterial Protein Content in Spirulina obtususus based on Spectroscopic Technology [D]. Hangzhou: Zhejiang University, 2020.

［6］OU Y, ZHENG S, LIN L, et al. Protective effect of C-phycocyanin against carbon tetrachloride-induced hepatocyte damage in vitro and in vivo［J］. Chem Biol Interact, 2010, 185(2):94-100.

［7］MANCONIA M, PENDÁS J, LEDÓN N, et al. Phycocyanin lipo⁃ somes for topical anti-inflammatory activity: In-vitro in-vivo studies ［J］. Pharm Pharmacol, 2009, 61(4):423-430.

［8］CADDEO C, CHESSA M, VASSALLO A, et al. Extraction, purifi⁃ cation and nanoformulation of natural phycocyanin (from Klamath algae) for dermal and deeper soft tissue delivery［J］. Biomed Nano⁃ technol, 2013, 9(11):1929-1938.

[9] THANGAM R, SURESH V, ASENATH P, et al. C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antip. roliferative activity through induction of apoptosis and G0/G1 cell cycle arrest [J]. Food Chem, 2013, 140(1-2):262-272.

[10] MIN S K, KWON Y S, CHO M K, et al. Nasal delivery of antioxi⁃ dants by cholesterol-incorporated liposomes extends the neuropro ⁃ tective time window in cerebral ischemia[J]. Current pharmaceuti⁃ cal design, 2017, 23(40):6223-6230.

[11] CASTANGIA I, MANCA M L, CATALÁN-LATORRE A, et al. Phycocyanin-encapsulating hyalurosomes as carrier for skin deliv ⁃ery and protection from oxidative stress damage［J］. Mater Sci Ma⁃ ter Med, 2016, 27(4):75.

［ 12］ Shen Xiangyang . Research and application of extraction purification and refining of algal blue protein from Spirulina obtususifera [D]. Nanning: Guangxi University, 2019.

［13］MADHYASTHA H K, RADHA K S, NAKAJIMA Y, et al. uPA dependent and independent mechanisms of wound healing by C- phycocyanin［J］. Cell Mol Med, 2008, 12(6B):2691-2703.

[14] MADHYASTHA H K, MADHYASTHA R, NAKAJIMA Y, et al. Regulation of growth factors-associated cell migration by C-phyco ⁃ cyanin scaffold in dermal wound healing[J]. Clin Exp Pharmacol Physiol, 2012, 39(1):13-29.

［15］MANCONI M, MURA S, MANCA M L, et al. Chitosomes as drug delivery systems for C-phycocyanin: Preparation and characteriza⁃ tion［J］. Int J Pharm, 2010, 392(1-2):92-100.

[16] MADHYASTHA H K, MADHYASTHA R, THAKUR A, et al. c- Phycocyanin primed silver nano conjugates: studies on red blood cell stress resilience mechanism [J J]. Colloids Surf B Biointerfac⁃ es, 2020, 194:111211.

［ 17］ Liu Qi, Li Wenjun, Lu Lina, et al. Protective effects of phycocyanin on radiation-induced oxidative damage in mice [J]. Nuclear Technology, 2018, 41(1):31-36.

[18] GROVER P, BHATNAGAR A, KUMARI N, et al. C-Phycocya⁃ nin-a novel protein from Spirulina platensis-In vivo toxicity, anti⁃ oxidant and immunomodulatory studies［J］.Saudi J Biol Sci, 2021, 28(3):1853-1859.

［19］Jiang Guoqing, Yan Qiuli, Li Dong, et al. Progress of extraction, purification and stabilization of cyanobacterial proteins in Spirulina［J］. Journal of Food Safety and Quality Testing, 2021, 12(6):2332-2338.

［20］ Sun Yingxin. Study on anti-paraquat induced pulmonary fibrillation in rats by Spirogyra albicans blue protein［D］. Beijing: University of Chinese Academy of Sciences, 2012.

［21］ Zhai Shixiang. Research on the mechanism of in vitro and in vivo anti-hepatic fibrosis of Spirulina alginata [D]. Bejing: University of Chinese Academy of Sciences, 2020.

［22］ Han Min Min. Anti-cellulite effect of Spiroplasma obtusum and its mechanism [D]. Nanning: Guangxi University of Traditional Chinese Medicine, 2021.

［23］Zhang Xin, Li Jianyong, Gong Xingguo. Separation of C-phycocyanin subunits and antitumor activity of Spirulina [J]. Journal of Zhejiang University (Science Edition), 2010, 37(3):319-323.

［24］ Chu Jing, Zhou Xiaolan, Wang Lixin, et al. Study on the anticancer effect of C-alginin on breast cancer cells［J］. Genomics and Applied Biology, 2020, 39(2):934-940.

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The functional cosmetics market has been experiencing remarkable growth in recent years, driven by increasing consumer awareness and demand for products that offer more than just aesthetic benefits. Functional cosmetics, also known as cosmeceuticals, are products that combine cosmetic and therapeutic properties, providing users with benefits such as anti-aging, skin hydration, sun protection, and more. This article delves into the key trends, drivers, challenges, and future prospects of the functional cosmetics market.

Market Overview

Functional cosmetics are designed to enhance the appearance of the skin while delivering additional benefits like hydration, anti-aging, and protection against environmental damage. These products often contain active ingredients such as vitamins, antioxidants, peptides, and botanical extracts that promote skin health. The market for functional cosmetics is broad, encompassing skincare, haircare, and personal care products.

Key Drivers

1. Increasing Consumer Awareness: Consumers are becoming more knowledgeable about the ingredients in their skincare products and are seeking out items that offer specific benefits. The desire for products that provide both aesthetic and therapeutic effects is a significant driver for the functional cosmetics market.

2. Aging Population: The global aging population is a major factor fueling the demand for anti-aging products. Functional cosmetics that promise to reduce wrinkles, improve skin elasticity, and provide a youthful appearance are in high demand among older consumers.

3. Technological Advancements: Innovations in cosmetic science and technology have led to the development of more effective and sophisticated functional cosmetic products. Advanced delivery systems, such as nanoparticles and liposomes, enhance the efficacy of active ingredients, driving market growth.

4. Rise of Natural and Organic Products: There is a growing trend towards natural and organic cosmetics, driven by consumer preference for safer and eco-friendly products. Functional cosmetics that incorporate natural ingredients are gaining popularity, aligning with the clean beauty movement.

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Market Segmentation

The functional cosmetics market can be segmented based on product type, application, and distribution channel.

1. Product Type:

   - Skincare: Includes moisturizers, serums, anti-aging creams, sunscreens, etc.

   - Haircare: Includes shampoos, conditioners, hair masks, and treatments.

   - Personal Care: Includes deodorants, oral care products, and others.

2. Application:

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   - Sun Protection: Sunscreens and products with SPF.

   - Moisturizing: Hydrating creams and lotions.

   - Whitening and Brightening: Products aimed at improving skin tone and reducing pigmentation.

3. Distribution Channel:

   - Online Retail: E-commerce platforms and brand websites.

   - Offline Retail: Supermarkets, specialty stores, and pharmacies.

Challenges

Despite its promising growth, the functional cosmetics market faces several challenges:

1. Regulatory Hurdles: The regulatory landscape for functional cosmetics is complex, varying significantly across regions. Compliance with different regulations can be challenging for manufacturers and can impact product development and market entry.

2. High R&D Costs: Developing functional cosmetics involves significant investment in research and development. The high costs associated with clinical trials, ingredient testing, and product formulation can be a barrier for new entrants and smaller companies.

3. Consumer Skepticism: While there is growing interest in functional cosmetics, some consumers remain skeptical about the efficacy of these products. Clear communication of benefits and evidence-based claims are essential to gain consumer trust.

Regional Insights

The functional cosmetics market exhibits regional diversity in terms of demand and consumer preferences. Asia-Pacific is a significant market, driven by high consumer awareness and preference for skincare products, particularly in countries like South Korea, Japan, and China. North America and Europe also represent substantial markets, with a strong focus on anti-aging and natural products.

Competitive Landscape

The market is highly competitive, with numerous global and regional players. Key companies operating in the functional cosmetics market include L’Oréal, Estée Lauder, Procter & Gamble, Shiseido, and Unilever. These companies are investing heavily in research and development, product innovation, and marketing to maintain their competitive edge.

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Future Outlook

The future of the functional cosmetics market looks promising, with ongoing advancements in cosmetic science and growing consumer demand for multifunctional products. The trend towards personalized skincare solutions and the incorporation of artificial intelligence in product recommendations are expected to further drive market growth. Additionally, the increasing focus on sustainability and ethical practices will shape the development of new functional cosmetic products.

In conclusion, the functional cosmetics market is poised for continued growth, driven by consumer demand for products that offer both aesthetic and therapeutic benefits. While challenges such as regulatory compliance and high R&D costs exist, the market’s future remains bright, with innovation and sustainability at the forefront of its evolution.

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• Hỗ trợ trắng sáng, làm mờ vết nhăn trên da.

• Hỗ trợ ngăn ngừa lão hóa, giúp làn da trông căng bóng mịn màng.

🔹 Sử dụng 𝐂𝐞𝐥𝐥𝐜𝐨𝐬 𝐌𝐞𝐬𝐨 - 𝐄𝐥𝐢𝐭𝐞 𝐏𝐞𝐩𝐭𝐢𝐝𝐞 𝐀𝐦𝐩𝐨𝐮𝐥𝐞 sau khi thực hiện các liệu trình xl không chỉ giúp các tổn thương trên da nhanh lành hơn, mà còn cung cấp nhiều dưỡng chất chăm sóc da hiệu quả.

[yaffyna-tries-doing-things]

Alright I got tired of searching for vitamic C serum without citrus extracts (Im allergic) so I decided to make it myself. I wont poat the exact formula, but heres what I did:

- Mixed distilled water with xantan and guar gums

- Added IPD and DermoSoft to water

- Mixed actives: centella extract, Vitamin C in liposomes, gialuron (I got really sensitive, easily damaged skin)

- Mixed astaxantine, vitamin e and cetiol C5 and added that to water with IPD

- Mixed actives and base

- Dissolved methylparabene in a propyleneglicol

- Mixed that all together.

I added too much of gums, so it turned out a bit jelly-like, but overall skin looks very smooth. Update after a few weeks of use