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physalian · 2 months

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I think the other thing that bothers me with the flood of AI into everything is how grandiose the companies marketing it make it seem. A Meta AI ad (when every Meta commercial is equally pretentious, ngl) treats it as the next great thing to bring the world together, an inspiration to us all, making our lives easier, yada yada.

The part of that commercial that stuck with me was this lady on a train, looked like a student, asking the Robot to summarize something for her. Looked like a page of notes. And like… lady you aren’t learning a damn thing if the Robot takes your notes and then summarizes them. Yes we’ve always had the means to cheat and no attempts to defend against it will ever work so long as cheaters lack the desire to learn, or suffer under too much pressure to get a good grade over an actual education.

Pretending you didn’t manufacture the problem your new product exists to create is nothing new. Tech is just like that. Capitalism is just like that. But I see people, smart people, buying into this bullshit and not seeing the forest for the trees. AI as a concept isn’t the problem, I know this. “AI” is such a broad term that lumping extremely useful tools in with art theft doesn’t help either side of the argument.

I don’t think for a second that any of the companies pushing it feel an ounce of guilt or had a shred of forethought before unleashing their utopian tools onto the market beyond the profits they could make. I don’t think the people who first made it did so maliciously. I’m just sick of the argument that “it’ll make lives easier and that’s worth the side effects”.

I was a student who rarely had to study for things—if I didn’t learn it in class during lecture, staring at my notes and cramming the night before the test wouldn’t fix anything. I had a very good retention of knowledge and a mental block to the concept of studying.

But when I really needed to make sure I didn’t wing it on a test, shocker, studying actually helped. I’d completely skipped over a concept on the study guide when reviewing, and that was the only question I got wrong on that test.

So seeing that actress on the train, pretending like the Robot summarizing her notes, while she’s on a train and has nothing better to do with her time anyway, as if it will in any way help her in the long run, is bullshit.

Nobody’s saying that artificial intelligence in medicine or forensics or computer science is a bad thing. It’s supposed to make the hard jobs, the menial jobs, the jobs that human error cannot compete with, easier. It’s not supposed to remove any sense of ambition, of trial and error, of failure and learning from it.

I can’t say these people had no idea what the world would do with these tools. Did you not think someone would use ChatGPT to cheat and do their homework and write their essays for them? Did you not think freelance writers and graphic designers would get fired en masse by cheap companies who can consult a computer for free? Did you not think copyrighted art, made by artists who are already struggling, would be stolen, and that they’d be mad about it? Did you not think singers and musicians might have something to say about their voices, wholly unique to them, and their lyrical and songwriting ability, being generated by a machine for free? Did you not think about the rampant misinformation that would abound by a robot that cannot have integrity, common sense, or think critically? Did you not think about how easy it is now to forge political images and speeches, to incite violence in gullible people who can’t spot a fake? Did you not think about how those images can start wars and cause catastrophe?

If you thought people would only use it for Instagram filters and generating surrealist nonsense at parties, you're criminally naive.

Piracy has always existed. Cheating has always existed. Ripping off someone else's book or script or speech or art style has always existed. The thing is though, that piracy comes with a risk of viruses and malware if you don't know what you're doing. Cheating takes finesse and risk if you get caught, especially now. Ripping off another's work still takes the time and effort to replicate it by hand. AI didn't invent any of this, AI just removed the barrier of entry and asked, why not?

I’ve quoted this movie before in my argument but goddamn, nothing fits better:

"Don't you see the danger, John, inherent in what you're trying to do here? Genetic power is the most awesome force the planet has ever seen but you wield it like a kid who's found his dad's gun.... I'll tell you the problem with your scientific power that you're using. It didn't require any discipline to attain it. You know, you read what others had done and you took the next step. You didn't earn the knowledge for yourself, so you don't take any responsibility for it. "You stood on the shoulders of geniuses to accomplish something as fast as you could and before you even knew what you had, you patented it, and you packaged it, and you slapped it on a plastic lunch box and now you're selling it. You're selling it. "Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should."

--Ian Malcom, Jurassic Park

#ai #fuck ai #anti ai #meta ai

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hanibalistic · 1 year

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#999A92 | HAN. JISUNG.

genre | hurt/comfort, found family au/brother!han & brother!jisung

word count | 1955

warning | mention of being sick, mention of puking

note | i remember puking once. didn't like it.

universe | tciu

your splitting headache hummed at a frequency too high to hear, but han knew it only lasted for a few seconds because his blurred eyesight immediately regained perfection. the glass cup previously in his hand was broken into tiny pieces from the faint moment of uncontrolled strength caused by your headache.

jisung perked up from the couch, the side of his face illuminated by the colors on the television screen. his eyes were wide from the abrupt noise han made, although the breaking of cups itself hasn't been uncommon today. he would know. he was in charge of reversing the process of every breakage. "you broke another cup?"

"it's in the sink. thanks," han grumbled as he turned away from the ingredients he carefully laid out for a cup of hot tea. he needed something to combat your fever and its unsurprisingly severe effects on him.

jisung watched han from his peripheral vision. his brother sluggishly moved from one point of the kitchen to another, grabbing a cup of water, it seemed. he could tell han was annoyed, but more so defeated than being doused in a fit of rage because he hadn't been able to do anything successfully today.

it started with your abrupt migraine this morning. the twins were grossly unprepared for the pain spiking in your head to be the first thing they experienced. they could not guard against it, causing the ground to shake briefly and the light bulbs around the house to pop. changbin called the school about your absence on his way out to buy new light bulbs and over-the-counter medicine. meanwhile, han failed his multiple attempts to clean the shattered glass on the floor. everytime your headache spikes, he loses control over his actions.

trying to cook breakfast was a terrible idea. han should have known how much of a hassle it would be to make food, but he wasn't willing to deviate from his daily routine over inconsistently-timed outbursts. all that resulted was an uproar of stove fire and eggs flipped high to the ceiling. jisung was already pouring a bowl of likely overdue cereal three groans into the breakfast journey.

without school occupying their time, which at this point the twins weren't sure if they preferred, they decided to put a movie on while they waited for changbin's return. but trying to pay attention to the screen and take all plot points proved challenging, too. even though they've somewhat gotten used to being influenced by the flu you caught, the ringing noise in their ears and the increasing feeling of shared pain still took up most of the space in their head. using a movie as a distraction was useless.

"he's taking an awful long time to get medicine," han muttered when he was within earshot.

jisung chuckled faintly as he watched han drag himself to the other end of the couch and slump down. there was barely any space left after jisung laid himself down with a blanket over his knees, but he buckled his knees to avoid being sat on. as han dropped onto the couch, he raised a finger slightly to catch the hot water that spilled over the edge of han's cup and discreetly returned it to where it came from. han took notice of it, grimaced, and said nothing.

"maybe there's a lot of people at the pharmacy," jisung said.

han put his hand under the cup to further heat the water up. his chest heaved steadily with each clipping of commercials on the television, enjoying this strange moment of calm instead of refuting jisung's claim.

he didn't think there were a lot of people at the pharmacy or the department store, whichever changbin was at. he believed changbin was taking so long because he didn't know what kind of medicine to get for the flu. he never had to get one for himself, and he never had to for a child. he was now forced to gather information on which of the millions of options work best, which, if he knew better, all of them technically should work.

that was a roundabout way to say han didn't think changbin was fit to be a parent, let alone you three's parent.

"what do you think about him?"

jisung peered without turning his head. he was comfortable lying on his forearm. "who? changbin?"

"yeah." han nodded.

there was a soft, nonchalant hum. jisung was thinking, but the hum could very well be an indifferent response, serving as the end of the conversation. that wouldn't be far off from what jisung thought about changbin. he managed to see into changbin's past the first day you met, and nothing was interesting. he couldn't determine if the man was good or bad. if han was asked about what he saw in changbin's past, which was mostly blood and death, he wouldn't be able to use that to make up an answer about his character either.

all there was of changbin now was that he was stoic, straightforward, and didn't enjoy speaking to any of you. jisung didn't care for social interactions with him enough to dislike the fact that he was limited to it.

"there must be something you want to say," han urged quietly.

"i don't know him well enough," jisung said. "i'm waiting for him to mess up."

"and i want to go home," han took a short sip of water, "i want mom and dad back."

jisung raised a brow in mild surprise. han has never explicitly expressed his liking toward your old foster home. he was always the harder one to read; he would speak, usually on your behalf, but he wouldn't say anything about himself. he pointed out apparent things and kept his opinions to himself. it was easy to suspect he didn't like it there, so hearing him address the married couple you previously housed with as mom and dad in this context was unexpected.

"i don't understand why they never adopted us," jisung muttered.

han's eyes reflected the colors flickering across the television screen. a door down the hallway opened before another one was closed; you likely left your room to use the bathroom. at least you managed to get out of bed. he swore he felt a bad case of growing pains just now. his chest moved slowly once and stopped, then he softly responded, "i think you know why. we all know–argh!"

the glass cup in han's hand ripped a few cracks around its body before it shattered, letting the liquid inside leak onto his lap. jisung opened his squeezed-shut eyes to catch the television pause from its shaking. he inwardly sighed at the faint hum of the commercial jingle in the company of your weeping from the bathroom. the neighbors may have a complaint or two after today.

sparing han a brief glance while he got off the couch to check on you, he saw that han was trying to get all the glass pieces off his thighs and the couch surface. he didn't need any extra help, and even if he did, jisung wouldn't lend a helping hand when you were crying so loudly in the bathroom. bare feet pitter-pattered their way across the floor to the hall, where among a wall of shadow was the light beaming in the size of a single door. jisung approached the frame and peeked inside, finding you on the floor with your head resting on the toilet seat and one of your hands halfway into the toilet bowl.

he made a throaty noise of disdain upon your tear-stricken face as he crouched next to you. "han broke another cup. his–" he rolled his eyes skyward and hummed–"fifth one today."

you hiccupped away the acidic taste in your mouth. "i puked."

"i figured." he arched his neck to look inside the toilet. grimacing, he reached a hand up to press on the silver handle. "you also didn't flush."

"because i was puking!" you exclaimed, your teary voice covered by the rush of water draining the fluids down the toilet.

it started as a bad stomachache, then there was an abrupt rush of sourness at the back of your mouth, flooding onto your tongue with your saliva. you went to the bathroom to spit the phlegm, but the second you bent your waist, the urge to puke took over. the pain all over your body, your aversion to puking, the suddenness of its arrival, and the stamina it took forced you to burst into tears.

"i'm hungry," you muttered, featured scrunching up. "i wanna eat mom's porridge."

jisung stared at you in silence for a while. the consensus was that switching foster homes was a wrong arrangement. unfortunately, it wasn't an agreement came to by anyone who would be impacted by it. it never was. and han was right. he knew why you three were never adopted. the glass pieces on the floor and the rumbling of apartment walls were enough trouble. being under watchful eyes was a wicked responsibility not all parents would care to share.

he often wondered how your mother would have reacted. your mother–the woman whose womb he slept in for however many hours or days before you three were found. he wouldn't exist if she was alive, but he admitted he possesses a discreet yearning to be loved, always be your brother, and be normal. sadly, the current story was his birth acting as a result of her death. he would always be the remains of your mother's undoing–his mother's demise.

"i miss her food too," jisung said as he reached for a tissue to wipe your mouth. "come on, let's go outside."

he clumsily took you into his arms and stood up. han had already returned to his seat on the couch when you arrived. the water was gone from his lap and the glass pieces gathered on a tissue paper on the coffee table. he made space for you to lay down, your head on jisung's lap and your legs curled to your chest. the television program switched from commercials to an old drama show that was surprisingly intriguing. at least the human-spoken dialogues were better white noises than loopy commercial jingles.

"they puked and started crying," jisung informed.

"all of a sudden?" han scoffed out a chuckle.

he glanced down at you and frowned when he caught jisung secretly taking the sickness from you through his palm on the side of your head. you three have agreed to cut down on healing you at any minor inconveniences to hone your resilience. besides, it was ironic that they wanted to be like other regular kids but wouldn't let simple things like a bloodied knee and catching a cold happen to you. your chest heaved according to your hiccups–you're just beginning to calm down from crying. han looked away from jisung's hand and decided he'd say something.

"changbin is gonna be upset when he comes back and finds out [name] doesn't need the medicine anymore."

jisung froze in surprise. he snapped his head to pull a face. "how would you know? are you two best friends?"

"he's always upset." han shrugged.

"i think that's just his face."

han waited a moment before he laughed. "he does look upset all the time."

"oh hey, here," the pharmacist said, holding out a small box of allergy pills. "seems like you need it."

changbin tilted his head with furrowed brows, his hand letting go of the cash in his wallet. "what?"

"you kept sneezing. it might be allergies," the pharmacist said. "either that, or someone is talking about you."

changbin sent a half glare toward the man. he didn't believe in those superstitions.

"give me the pills."

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iguessitme · 2 years

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Interesting similarity between Emesis and german horror film

Just watched Emesis blue and I absolutely love this film. The references to” The shining “was so well implemented and an interesting choice (will look into them later) I would like to bring attention to a detail that I'm not 100% sure even is a reference but is interesting to consider.

WARNING SPOILERS AHAED

In the last act Medic skin i really pale, has visible eye bags and is wearing a Black turtleneck.

This look resembles one of the main character from German silent horror movie ‘’ The Cabinet of Dr. Caligari ‘.

Cesare was a lunatic that slept through all 23 years of his life was used by the director of the asylum to commit murders during the night. The doctor was obsessed with the story of an 18th-century mystic named Caligari, who used a Man named Cesare to commit murder In Italian towns. He swore to become Caligari and proceed with the experiments himself as the New coming patient a lunatic will become his Cesare.

Outside of Just Visual similarities i believe there is a strong connection between this film and Emesis blue. The pills that are seen throughout the movie seem to have strong importance to the plot, but it is never explained how relevant they are. In an upload on the Fortress Films YouTube Chanel called „𝙀𝙈𝙀𝙎𝙄𝙎® 𝘿𝙄𝘼𝙕𝙀𝙋𝘼𝙈” we can learn more about this strange medical product.

The video opens with a reminder of the importance of Sleep to a human body, saying that it can also be assisted by medication. It is recommended to Take one pill of Emesis before sleeping. Although there are side effects to this drug such as drowsiness, memory loss and hallucinations. We can see medic experiencing all of them. Next, we are instructed to stare directly AT images presented on screen. All of them have words „Go to Steep now” blinking In the Middle of them.

It is revealed that the pills doc Has been ta king were the same ones as from the commercial.

As of now i don't have Any strong enough theories of how exactly they relate to the plot and Medici insanity. Clearly their Osage was the main reason for his hallucinations but i think it's possible that under their influence He committed a murder. The one that seems most Lilly to back up this claim is the mysterious Heath of scout's mother. Young mercenary was not pleased to see his friend again yelling that he wants to shoot him dead, why so sudden hate towards a man he was friendly with before? The women had two other appearances (that I can recall), we can see Her behind medic when He was standing before a respawn machine terminal, which instead of the boy himself lead to her apartment. The horrific scene when Her head is Dropped has an unnerving reappearance by the end of the medicine commercial.

That’s all i have for now. No idea if Any of this even matters but i couldn't Get it out of my head and the theories will keep MW up whole night.

goodnight

#tf2 #my ramblings #emesis blue #Team Fortress 2 #team fortress two #tf2 medic #tf2 scout #tf2 scouts ma #tf2 scouts mom #medic team fortress 2

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vax-seen · 15 days

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The Facade

Science: the backbone of our world. It is the tool we use to reason, study, explain, and determine everything about our world. Science isn't biased; it's not concerned with the outcome of new information. It doesn't care how long a practice has been trusted. It only focuses on the information we have now and what we can determine from it. Keep that in mind as you read the information presented in this blog.

Most U.S. citizens were raised to trust the CDC's guidelines, follow their doctor's advice, and adhere to the rules these institutions set for society. It’s no secret that our nation's health is in peril: Autism rates are skyrocketing, autoimmune disorders are increasing every year, and chronic illness is rampant. Most importantly, our life expectancy has started to decline. Why is this happening? Why do the institutions in charge of our health keep recommending practices that keep us sick and make them money? Why do most licensed doctors admit they never studied nutrition in their education nor consider it in their practice?

Nutrition is the foundation of health, yet doctors focus solely on prescribing medications to combat the side effects of our poor diets, as well as the side effects from all the other medications prescribed to Americans. The answer is simple: money. Keeping Americans sick is the overriding goal. There is no profit in a cure, and anyone who fails to see that is simply choosing to maintain their safe worldview out of fear. It takes courage to accept that you've been deceived, so I encourage you to have the strength to listen to the facts presented in this blog.

The COVID-19 vaccine represents a new type of "medicine" known as mRNA technology. It works by injecting a lipid nanoparticle that contains instructions for producing antibodies into the muscle tissue in your arm. The nanoparticle is coated in fat so that the cell walls can absorb it and follow its instructions to produce the appropriate antibodies. The immune system recognizes the cell producing something it didn't authorize and labels it as virally infected. It then sends white blood cells to destroy the infected cell. This isn't supposed to be a significant risk because the affected cells are localized in the injection site.

However, one major oversight by the CDC was the decision not to require aspiration for the COVID shots. Aspiration involves pulling back on the syringe before injecting to ensure the needle isn't in a vein or blood vessel. If it is, the doctor would see blood and adjust the needle to ensure the shot is injected into muscle, not intravenously. Without aspiration, many patients received the shot directly into their bloodstream, allowing the lipid nanoparticles direct access to the heart and affecting large numbers of cells there. The immune system destroyed these cells, leaving the heart weakened. Unlike other parts of the body, the heart cannot repair itself quickly. This weakened heart tissue has caused many people to collapse or die on sports fields. If you’ve noticed such cases in the months following mass vaccinations, it’s likely you’ve seen myocarditis, the condition caused by this process, unless censorship hid the videos before you could watch.

Looking back, it’s clear how this happened. The decision to forgo aspiration makes no sense, especially since the vaccine was meant to be intramuscular. The reasoning behind this policy was to prevent vaccine hesitancy—a dangerous and irresponsible choice. No government or authority should be allowed to make such decisions. The fact that this happened is a clear sign that safety was not their priority. Their primary motivation was money, and they developed a system to generate as much as possible.

First, they inflated the severity of COVID to make it seem more deadly than it was. The media, funded by big Pharma (as evidenced by all the drug commercials), instilled fear in the American public. They misrepresented information about alternative treatments like Ivermectin and Hydroxychloroquine, both of which are proven to be effective for treating RNA viruses, including COVID. Even though these medications are cheap and readily available, the government and media suppressed information about them. Ivermectin, which is less toxic than Hydroxychloroquine, should have been the first line of defense against COVID. Personally, I used Ivermectin when I had COVID, and all of my symptoms disappeared after two doses within 24 hours. Thousands of cases of successful treatment with Ivermectin exist, and India even made it their primary treatment for the entire country.

Here’s where things get strange: The government cannot issue an "emergency use authorization" unless there are no alternative treatments. In order to push mass vaccination, they set out to discredit and censor any alternative treatment. All major news networks, Facebook, Instagram, Google, and Twitter (before it changed ownership) implemented censorship to prevent "vaccine hesitancy." CNN even mocked Joe Rogan for using Ivermectin, calling it "horse medication." In reality, the inventor of Ivermectin won a Nobel Prize for its use in humans. CNN's portrayal was evil and misleading. The goal was to convince people that vaccination was their only option. Unfortunately, they succeeded, with over 77% of the U.S. population receiving the vaccine. They didn’t just make it seem like the only option—they made it mandatory for those who wanted to attend school or keep their job.

Why are institutions that Americans have trusted for decades committing such heinous acts? Why is science being manipulated? Why is safety not a priority? Why are hundreds of scientists and doctors censored, silenced, and stripped of their medical licenses when they try to go public with this information? Money. In summary, the government struck fear into the public, said the only solution was vaccination, and made it mandatory if you wanted to stay in school, keep your job, or travel. It resulted in $90 billion in profits for big Pharma. No wonder they sought the emergency use authorization. These actions have led to the death or permanent injury of millions of Americans, and the people responsible deserve to be imprisoned for life.

#vaccine genocide #big pharma #government corruption #cdc corruption #media bias

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beemovieerotica · 1 year

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"bUt cAnT wE tEsT oN hUmAnS" drives me nuts. New medicine/treatments/vaccines/surgeries/etc. can cause SO many issues. Like, have these people never seen those commercials going "If you or a loved one have been diagnosed with mesothelioma" or "If you or a loved one were diagnosed with this cancer after using this weed killer" or the "Hey your baby powder might have fucking asbestos in it"???

I mean fuck even after things have been ~officially tested~ I still wait a year or more before trying a new medication/vaccine/procedure/whatever and just let all the other guinea pigs test it out and see what happens to them first because sometimes! Things are missed! Or ignored!

There's literally a Wikipedia article on the largest pharmaceutical settlements for things like failure to disclose safety data, kickbacks and fraud.

It's the same when a new video game/console/phone/car comes out! Let everyone else go first and find all of the bugs/problems/see if the car explodes or the breaks stop working.

^^^^^^

To be clear though, hesitancy about vaccines has been a detriment of society with little basis in fact. Everyone was panicking about the covid vaccine like "it's NEW and EXPERIMENTAL!" No...mRNA vaccines have been tested on mice since the 90's. And the panic about the lyme disease vaccine prevented us from potentially eradicating that disease among humans, and now it's mutated beyond the point where a vaccine could ever be effective. I trust vaccines, they don't fuck around with all the hurdles somebody has to go through before any of that gets to the consumer level.

For other medications I generally trust the medical review process, but you're correct in that things can be unreliable if they aren't tested on a wide variety of bodies because of things like medical misogyny and ableism. Medical professionals are shocked when a medication has unexpected side effects for people who menstruate, like...did this never come up during trials? Oh, no, it didn't, because they didn't bother testing anyone beyond healthy ages 20-40 cis men.

It's also standard to only use male mice/cats/dogs/primates for most medication tests - I work with inverts and didn't know this was a thing until I went to a conference for the broader neuroscience community. Basically, female rats/mammals present "issues" for medical testing because of their reproductive hormone cycles ...... and so does half of the human population.

It's a complicated issue but yeah, it's not going to make things any safer by eliminating animal testing outright.

#ask #animal testing

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soniez · 5 months

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From Lab to Patient – The Evolution of Medicine Production

The journey of a medicine from a research laboratory to a patient’s bedside is a complex and intricate process. It involves rigorous scientific research, extensive clinical trials, stringent regulatory approvals, and sophisticated manufacturing processes. This blog will explore the evolution of medicine production, highlighting the role of leading pharmaceutical companies in India, including Centurion Healthcare, in bringing life-saving medications to the market.

The Genesis of Medicine: Research and Development

The Role of Pharma Companies in India

The development of new medications begins with a deep understanding of diseases and the biological mechanisms that drive them. Pharmaceutical companies in India, renowned for their robust R&D capabilities, play a pivotal role in this phase. Researchers at these companies work tirelessly to identify potential therapeutic targets and develop compounds that can modulate these targets effectively.

Preclinical Research

Before a new drug can be tested in humans, it must undergo extensive preclinical research. This involves laboratory and animal studies to assess the safety and efficacy of the compound. The goal is to gather enough data to support the initiation of clinical trials. This stage is crucial for ensuring that only the most promising and safe candidates move forward.

Clinical Trials: Testing in Humans

Phase I Trials

Once a compound has shown promise in preclinical studies, it enters Phase I clinical trials. These trials involve a small number of healthy volunteers and aim to evaluate the safety, tolerability, and pharmacokinetics of the drug. For a medicine manufacturing company in India like Centurion Healthcare, this phase is critical for determining the initial safety profile of the drug.

Phase II Trials

If Phase I trials are successful, the drug progresses to Phase II trials, which involve a larger group of patients who have the condition the drug is intended to treat. The focus here is on assessing the drug’s efficacy and further evaluating its safety. Pharmaceutical companies in India invest heavily in this phase to gather robust data that can support the drug’s potential therapeutic benefits.

Phase III Trials

Phase III trials are the most extensive and involve a large number of patients across multiple locations. These trials are designed to confirm the drug’s efficacy, monitor side effects, and compare it to standard treatments. For a medicine manufacturing company, this phase is critical for obtaining the data needed for regulatory approval.

Regulatory Approval

After successful Phase III trials, the data is submitted to regulatory authorities for approval. In India, the Central Drugs Standard Control Organization (CDSCO) is responsible for evaluating the safety and efficacy of new drugs. Obtaining regulatory approval is a significant milestone for any medicine company in India, allowing the drug to be marketed and made available to patients.

Manufacturing: From Lab Bench to Production Line

Scaling Up Production

Once a drug receives regulatory approval, the focus shifts to manufacturing. Scaling up production from laboratory scale to commercial scale is a complex process that requires significant expertise and investment. Medicine manufacturing companies in India, such as Centurion Healthcare, employ state-of-the-art technologies and adhere to stringent quality control measures to ensure that every batch of medicine meets the highest standards.

Quality Assurance and Control

Quality assurance and control are paramount in medicine manufacturing. Companies implement rigorous testing protocols to ensure that each batch of the drug is consistent in terms of potency, purity, and safety. This involves testing raw materials, in-process materials, and finished products. Pharmaceutical companies in India are known for their stringent quality control measures, which are essential for maintaining the trust of healthcare providers and patients.

Packaging and Distribution

Once manufactured, the medicines are packaged in a manner that ensures their stability and safety during transportation and storage. Packaging must protect the drug from environmental factors such as light, moisture, and temperature fluctuations. After packaging, the medicines are distributed to pharmacies, hospitals, and clinics, ensuring that they are readily available to patients.

Post-Market Surveillance

The journey of a medicine does not end with its launch in the market. Post-market surveillance is crucial for monitoring the drug’s performance in the real world. This involves collecting and analyzing data on the drug’s safety and efficacy from patients and healthcare providers. Pharmaceutical companies in India are actively involved in post-market surveillance to ensure that any potential issues are identified and addressed promptly.

Pharmacovigilance

Pharmacovigilance is a key component of post-market surveillance. It involves the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. Medicine manufacturing companies in India have dedicated pharmacovigilance teams that monitor and report any adverse events associated with their drugs, ensuring patient safety.

The Role of Technology in Medicine Production

Advanced Manufacturing Technologies

The pharmaceutical industry has embraced advanced manufacturing technologies to enhance efficiency and product quality. Techniques such as continuous manufacturing, automation, and advanced analytics are revolutionizing the way medicines are produced. These technologies enable medicine manufacturing companies to produce drugs more efficiently, reduce waste, and ensure consistent product quality.

Digital Transformation

Digital transformation is playing a significant role in the evolution of medicine production. Pharmaceutical companies in India are leveraging digital technologies such as artificial intelligence (AI), machine learning, and big data analytics to streamline their operations. These technologies are used in various stages of drug development and manufacturing, from identifying new drug targets to optimizing production processes and ensuring quality control.

Sustainability in Medicine Production

Sustainability is becoming increasingly important in the pharmaceutical industry. Companies are adopting environmentally friendly practices and technologies to minimize their environmental footprint. This includes using renewable energy sources, reducing waste, and implementing green chemistry principles. Medicine manufacturing companies in India are at the forefront of this movement, striving to make their production processes more sustainable.

Centurion Healthcare: Leading the Way

As a leading medicine manufacturing company in India, Centurion Healthcare is dedicated to advancing the field of medicine production. Our commitment to quality, innovation, and sustainability sets us apart in the industry. Here is how we are contributing to the evolution of medicine production:

Cutting-Edge Research and Development

Our R&D team is at the heart of our success. We invest heavily in research to discover and develop new therapeutic agents that address unmet medical needs. Our state-of-the-art facilities and collaboration with leading research institutions enable us to stay at the forefront of medical innovation.

Advanced Manufacturing Capabilities

At Centurion Healthcare, we utilize advanced manufacturing technologies to produce high-quality medicines efficiently. Our manufacturing facilities are equipped with the latest equipment and adhere to international standards of quality and safety. We are committed to continuous improvement and innovation in our production processes.

Comprehensive Quality Control

Quality is our top priority. We have established rigorous quality control measures to ensure that every product we manufacture meets the highest standards. From raw material testing to final product release, our quality assurance team meticulously monitors every step of the production process.

Commitment to Sustainability

We are committed to making our production processes more sustainable. We have implemented various initiatives to reduce our environmental impact, including energy-efficient practices, waste reduction programs, and sustainable sourcing of raw materials. Our goal is to contribute to a healthier planet while providing high-quality medicines to patients.

Conclusion

The evolution of medicine production is a testament to the dedication and innovation of pharmaceutical companies in India. From the initial stages of research and development to the manufacturing and distribution of life-saving medications, every step in this journey is crucial. At Centurion Healthcare, we are proud to be a part of this dynamic industry, contributing to the health and well-being of patients worldwide.

As a leading medicine company in India, we remain committed to advancing the field of medicine production through cutting-edge research, advanced manufacturing technologies, and a steadfast commitment to quality and sustainability. Our journey from the lab to the patient’s bedside is driven by a passion for excellence and a desire to make a meaningful impact on global health.

#Medicine manufacturing company in India #Pharma companies in India #Medicine company in India #Pharmaceutical companies in India #Medicine manufacturing company

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hypeptide · 9 months

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Peptides – unique medicines

In contrast to proteins and small molecules, peptides represent a unique class of pharmaceutical compounds that are biochemically and therapeutically distinct from both. As intrinsic signaling molecules for many physiological functions, peptides offer an opportunity for therapeutic intervention that closely mimics natural pathways. In recent years, peptides have received increasing attention as a therapeutic approach.

The origin and development of in vitro peptide drugs

Polypeptides are amino acid derivative compounds containing at least one amide (peptide) bond. From a structural point of view, polypeptides include various types of peptides, such as linear peptides, cyclic peptides, delipidated peptides, etc. According to function, they can also be divided into antibacterial peptides and hormones. Regulatory peptides, neuroactive peptides, etc. [1].

In the early 20th century, research on peptides focused primarily on the effects of human signaling hormones. Insulin is a classic example of endogenous hormone therapy. It was the first peptide drug to be used clinically and is by far the most commercially successful [2] because it revolutionized the treatment of type I diabetes.

Advantages, disadvantages and new attempts of peptide drugs

The key factors for the success of peptide drugs are the effectiveness, specificity and safety of the mode of action of the peptide [3]. The rapid clearance of peptides from the body means that they do not accumulate in tissues and are relatively less toxic to the human body [4]. However, the limitations of peptide drugs are as obvious as their advantages.

Since peptide drugs are easily cleared from the serum, this also results in low bioavailability of peptide drugs. Furthermore, peptides generally have poor cell membrane permeability, which limits their use in targeting intracellular targets. Therefore, the development of peptide therapeutics has mainly focused on extracellular targets. Moreover, because they cannot penetrate the intestinal mucosa and need to be administered subcutaneously or intravenously, the convenience and compliance of peptide drugs in actual treatment are reduced [4].

Improving the bioavailability and efficacy of peptide drugs is also a popular research area. There have also been advances in universal and reproducible oral administration, as well as intracellular delivery of peptide drugs [4]. Cyclic peptides, a category of peptide drugs, are an emerging form of drugs designed to solve problems.

Cyclotides—a new form of peptide drugs

Cyclic peptides (including cyclodeposition peptides and bicyclic peptides) have many favorable properties as therapeutic agents and research tools. Compared with linear peptides, cyclic peptides have better proteolytic resistance and structural stability.

Currently, several cyclic peptides have become highly successful drugs, including vancomycin (antibacterial), daptomycin (antibacterial), cyclosporine A (transplantation immunosuppressant), and caspofenside (antifungal). Inspired by natural products, chemists have developed many methods to prepare cyclic peptides via N-to-C, side chain to side chain, or main chain to side chain cyclization. Some synthetic cyclic peptides, such as eptifibatide (used to treat heart disease), octreotide (a somatostatin mimetic used to treat acromegaly and diarrhea), cyclic RGD peptide, and linalotide Peptides have also been approved by the FDA for clinical or late-stage clinical trials [5].

Peptidomimetics – chemically synthesized peptide drugs

In terms of new drug strategies, in order to overcome the instability defects of peptides, in addition to modifying polypeptides to varying degrees like cyclic peptides, peptidomimetic compounds are also another reasonable means.

Peptidomimetic compounds are a class of compounds whose pharmacophore simulates natural peptides or proteins in three-dimensional space and retains the ability to interact with biological targets and produce the same biological effects [6]. The difference is that peptoids avoid the inherent defects of natural polypeptides and improve biological activity and stability.

Peptide drugs, whether isolated from the innate immunity of various species (including mammals, amphibians, fish, insects, plants and bacteria), or designed based on structure-activity relationship research, serve as a new structural drug , all have great potential [7]. Here we introduce a high-throughput method that can quickly identify and find suitable drugs – constructing a peptide library.

Currently, there are nearly a hundred peptide drugs on the global market, and research on new peptide therapeutic drugs continues at a steady pace, with more than 100 peptides in the clinical development stage and another 400-600 peptides in the preclinical research stage [2 ]. The utilization of peptides as therapeutics has evolved over time and continues to evolve as drug development and treatment paradigms change.

references

Luca Gentilucci. Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization. Curr Pharm Des. 2010;16(28):3185-203.

Markus Muttenthaler. Trends in peptide drug discovery. Nat Rev Drug Discov. 2021 Apr;20(4):309-325.

Keld Fosgerau. Peptide therapeutics: current status and future directions. Drug Discov Today. 2015 Jan;20(1):122-8.

Antoine Henninot. The Current State of Peptide Drug Discovery: Back to the Future?. J Med Chem. 2018 Feb 22;61(4):1382-1414.

Patrick G Dougherty. Understanding Cell Penetration of Cyclic Peptides. Chem Rev. 2019 Sep 11;119(17):10241-10287. Epub 2019 May 14.

Josef Vagner. Peptidomimetics, a synthetic tool of drug discovery. Curr Opin Chem Biol. 2008 Jun; 12(3): 292–296.

Sylvie E Blondelle. Optimization and high-throughput screening of antimicrobial peptides. Curr Pharm Des. 2010;16(28):3204-11.

B Guixer. Chemically synthesized peptide libraries as a new source of BBB shuttles. Use of mass spectrometry for peptide identification. J Pept Sci. 2016 Sep;22(9):577-91.

Website: https://www.ks-vpeptide.com

#peptides #biology

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