#leticia almeida

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COVID Double Whammy

The difference between a mild bout of COVID-19 and a severe, potentially fatal form of the disease is largely down to the patient’s own immune response to the virus – excessive inflammation being linked with hospitalisations and death. This has prompted researchers to find drugs that can quell such rampant responses. And, in a screen of more than 2,500 drugs approved for use in humans, researchers found that among the most promising was one called niclosamide. When the drug was applied to SARS-CoV-2-infected human macrophages (shown), it dramatically inhibited the cells’ inflammasomes (green) – complexes that produce and pump out inflammatory factors. As a bonus, the drug also dialled down replication of the virus. Niclosamide is currently used as an oral treatment for tapeworm and would need reformulating to work in the lungs. The fact that it potentially offers a double punch against COVID, though, suggests such reformulation would certainly be worthwhile.

Written by Ruth Williams

Image by Leticia Almeida and Keyla Sá, Universidade de São Paulo

Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

Image copyright held by the original authors

Research published in Science Advances, September 2022

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leticia almeida fica insegura por gozar e tesão sexy punheta safadinha💦🍆❤

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CALIFICACIÓN PERSONAL: 5 / 10

Título Original: Respira: Transgénesis

Año:  2019

Duración: 77 min

País:  Argentina  

Director: Gabriel Grieco

Guion: Gabriel Grieco

Música:   Pablo Salas  

Fotografía:   Fabián Giacometti  

Reparto: Luz Cipriota, Sofía Gala Castiglione, Leticia Brédice, Nicolás Pauls, Gerardo Romano, Lautaro Delgado, Joaquín Rapalini Olivella, Paula Brasca, Daniel Valenzuela, Walter Jakob, Ezequiel De Almeida

Productora: Black Mandala

Género: Thriller

https://www.imdb.com/title/tt6569692/

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