#igfr

[atthedugouts]

I'm so tired from traveling in my delirium I thought of more Iggy names

Iggapher

Iggnelius

Iggalicious

Igxander

Igfred

[ffiesinger]

Éboulements : quand la crise climatique change le visage des Alpes • FRANCE 24

See on Scoop.it - Club euro alpin: Economie tourisme montagne sports et loisirs

loadYouTubePlayer('yt_video_Nu806s1t98o_4COyBjcQVveIVEU1');

En août, un éboulement massif a coupé la circulation entre la France et l’Italie, dans la vallée de la Maurienne. Au total, 16 000 mètres cube de roches ont atteint trois infrastructures : la voie ferroviaire, la route départementale et l'autoroute. Les images, spectaculaires, deviennent presque habituelles. Dans les Alpes, les canicules et le dérèglement climatique changent le visage de la montagne. Dangereuse, fragilisée, elle devient imprévisible.   En savoir plus avec notre article : https://f24.my/9pye.y 🔔 Abonnez-vous à notre chaîne sur YouTube : https://f24.my/YTfr 🔴 En DIRECT - Suivez FRANCE 24 ici : https://f24.my/YTliveFR 🌍 Retrouvez toute l’actualité internationale sur notre site : https://www.france24.com/fr/ Rejoignez-nous sur Facebook : https://f24.my/FBvideos Suivez-nous sur X (Twitter) : https://f24.my/Xvid Parcourez l’actu en images sur Instagram : https://f24.my/IGfr Découvrez nos vidéos TikTok : https://f24.my/TKfr Recevez les dernières infos sur Telegram : https://f24.my/TGfr

Francis Fiesinger Pro's insight:

#montagne #risquesnaturels #climat 

[jhavelikes]

or the past several decades, research in understanding the molecular basis of human muscle aging has progressed significantly. However, the development of accessible tissue-specific biomarkers of human muscle aging that may be measured to evaluate the effectiveness of therapeutic interventions is still a major challenge. Here we present a method for tracking age-related changes of human skeletal muscle. We analyzed publicly available gene expression profiles of young and old tissue from healthy donors. Differential gene expression and pathway analysis were performed to compare signatures of young and old muscle tissue and to preprocess the resulting data for a set of machine learning algorithms. Our study confirms the established mechanisms of human skeletal muscle aging, including dysregulation of cytosolic Ca2+ homeostasis, PPAR signaling and neurotransmitter recycling along with IGFR and PI3K-Akt-mTOR signaling. Applying several supervised machine learning techniques, including neural networks, we built a panel of tissue-specific biomarkers of aging. Our predictive model achieved 0.91 Pearson correlation with respect to the actual age values of the muscle tissue samples, and a mean absolute error of 6.19 years on the test set. The performance of models was also evaluated on gene expression samples of the skeletal muscles from the Gene expression Genotype-Tissue Expression (GTEx) project. The best model achieved the accuracy of 0.80 with respect to the actual age bin prediction on the external validation set. Furthermore, we demonstrated that aging biomarkers can be used to identify new molecular targets for tissue-specific anti-aging therapies.

Frontiers | Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification

[dreadloxholmes]

L'arc de triomphe des Antiques (Saint-Rémy de Provence) @ Saint-Remy-de-Provence #stremydeprovence #provence #vincentvangogh #escapefromthecity #breathfreshair #outdoorlife #takingabreak #holidays #landscapes #igersfrance #igfr #vacances #france #soirée #provenceeprintemps #relax (at Saint-Rémy-de-Provence)

[forsomemasses]

#deudeuche time 🇫🇷 #igfr #tbt (at Montmatre; Sacré-Coeur)

[ofjipizc]

When the day invites you out. #landscaping #landscape #igers #igday #пейзаж #paysage #boanoite #getout #photoofday #picoftheday #all_shot #landscapelovers #Colombia #Bogoteando #Lovebogota #instalove #instagood #awesome #friday #weekend #iguk #igus #igfr #instagram #instagrammers #bogotalife

[nbotvinnik]

... всегда есть "место", в котором тепло в любую погоду... Это может быть дом, может быть человек, может быть "уголок" внутри тебя.. Отправляйся туда, когда устал, когда нужно просто расслабиться и набраться сил, тепла.. .. А набравшись сил, отогревшись, сумей согреть того, кто придёт к тебе за теплом. . . Доброе утро ☀️ ☕ #Настроение #Осень #Утро #мысливслух #доброеутро https://www.instagram.com/p/B33vuw-IGFr/?igshid=2l1kbiyltoph

[nullshop]

JetElements v1.14.2 – Addon for Elementor Page Builder Nulled Download

JetElements v1.14.2 – Addon for Elementor Page Builder Nulled Download

JetElements v1.14.2 – Addon for Elementor Page Builder Nulled Download

  JetElements is an innovative addon for popular Elementor page builder. This plugin adds extensive modules to the existing ones, and allows to stuff the web pages with multiple content blocks.

Demo https://codecanyon.net/item/jetelements-addon-for-page-builder-elementor/20407053

Download https://www.filecad.com/igfR/JetEleme…

[academicheroes]

Cell Proliferation And Genes Assignment | Homework For You

Cell Proliferation And Genes Assignment | Homework For You

Task: Talk about intestinal cell proliferation and differentiation and the associated genes such as EGFR, IGFR-I, IGFR-II, KLF4, FGFR2, FGFR4, alkaline phosphatase, HNF1a and LGR5. Mention the effect of High fat diet on them. CLICK HERE TO PLACE AN ORDER 1- Intestinal cell proliferation and the associated genes (one page, 1-3 references). 2- Intestinal cell differentiation and the associated…

[dreadloxholmes]

Gravel Road @ Saint Remy de Provence ☝🏾L❤️✌🏾E. #stremydeprovence #provence #vincentvangogh #escapefromthecity #breathfreshair #outdoorlife #takingabreak #holidays #landscapes #igersfrance #igfr #vacances #france #soirée #provenceeprintemps #relax #clouds (at Saint-Rémy-de-Provence)

[healthtimetaylor]

EGCG may prove beneficial to improve gemcitabine sensitivity in inhibiting pancreatic cancer cell migration and invasion.

PMID:  Nutrients. 2019 Aug 9 ;11(8). Epub 2019 Aug 9. PMID: 31405071 Abstract Title:  Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine. Abstract:  Most pancreatic cancers are usually diagnosed at an advanced stage when they have already metastasized. Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea, has been shown to reduce pancreatic cancer growth, but its effect on metastasis remains elusive. This study evaluated the capacity of EGCG to inhibit pancreatic cancer cell migration and invasion and the underlying mechanisms. EGCG reduced pancreatic cancer cell growth, migration, and invasion in vitro and in vivo. EGCG prevented"Cadherin switch"and decreased the expression level of TCF8/ZEB1,β-Catenin, and Vimentin. Mechanistically, EGCG inhibited the Akt pathway in a time-dependent manner, by suppressing IGFR phosphorylation and inducing Akt degradation. Co-treatment with catalase or N-Acetyl-L-cysteine did not abrogate EGCG's effect on the Akt pathway or cell growth. Moreover, EGCG synergized with gemcitabine to suppress pancreatic cancer cell growth, migration, and invasion, through modulating epithelial-mesenchymal transition markers and inhibiting Akt pathway. In summary, EGCG may prove beneficial to improve gemcitabine sensitivity in inhibiting pancreatic cancer cell migration and invasion, to some extent through the inhibition of Akt pathway and epithelial-mesenchymal transition.

read more

[sisiad]

ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells

http://dlvr.it/R7VZqp

[cancersfakianakis1]

CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process

Abstract

Background

Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (CYR61/CCN1) expression level is correlated to osteosarcoma aggressiveness in preclinical model and in patient tumor samples. The aim of the present study was to investigate the CYR61-induced intracellular mechanisms leading to the acquisition of an invasive phenotype by osteosarcoma cells.

Methods

Modified murine and human osteosarcoma cell lines were evaluated for cell adhesion, aggregation (spheroid), motility (wound healing assay), phenotypic markers expression (RT-qPCR, western blot). Cell-derived xenograft FFPE samples and patients samples (TMA) were assessed by IHC.

Results

CYR61 levels controlled the expression of markers related to an Epithelial-mesenchymal transition (EMT)-like process, allowing tumor cells to migrate acquiring a competent morphology, and to be able to invade the surrounding stroma. This phenotypic shift indeed correlated with tumor grade and aggressiveness in patient samples and with the metastatic dissemination potential in cell-derived xenograft models. Unlike EGFR or PDGFR, IGF1Rβ levels correlated with CYR61 and N-cadherin levels, and with the aggressiveness of osteosarcoma and overall survival. The expression levels of IGF1Rβ/IGF1 axis were controlled by CYR61, and anti-IGF1 neutralizing antibody prevented the CYR61-induced phenotypic shift, aggregation, and motility abilities.

Conclusions

Taken together, our study provides new evidence that CYR61 acts as a key inducing factor in the metastatic progression of osteosarcoma by playing a critical role in primary tumor dissemination, with a process associated with IGF1/IGFR stimulation. This suggests that CYR61 may represent a potential pivotal target for therapeutic management of metastases spreading in osteosarcoma, in correlation with IGF1/IGFR pathway.

http://bit.ly/2FyR4ye

[erkantopuz]

⚠️Şeker sağlığınızı tehdit ediyor⚠️ 🔎Araştırmalar; aldığımız kalorilerin yüzde 56'sının, üç kaynaktan geldiğini ortaya koyuyor. Bunlar; rafine şekerler, ağartılmış un ve bitkisel yağlar. Bu besinler; bedenimizin işlevlerini yerine getirmesini sağlamak için gereken proteinler, vitaminler, mineraller veya Omega 3 yağ asitlerinin hiçbirini içermiyor. Ayrıca kanserin gelişimini destekliyor. ⚠️GLİKOZ ORANINI ARTIRIR 👉🏼Glikoz, vücutta sindirilmiş şekerin aldığı biçimdir. Nobel ödüllü Alman biyolog Heinrich Warburg; kötü huylu tümörlerin büyük ölçüde glikoz tüketimine bağlı olduğunu kanıtladı. Yani vücudun herhangi bir bölgesi çok fazla şeker tüketiyorsa, bunun nedeni büyük olasılıkla kanserdir. 👉🏼Glisemik endeksi yüksek gıdalar (şeker veya beyaz un), kandaki glikoz düzeyini hızla artırır. Kısacası şeker; kanserli dokuları besleyerek, daha hızlı büyümelerine neden olur. ⚠️KEMOTERAPİYE YANIT VERMİYOR 🔎Araştırmalar; insülin ve IGFR salgısının komşu dokulara da saldırdığını gösteriyor. Farelerle yapılan bir deneyde; kanserli hücrelere insülin ve IGFR enjekte edildi. 🔎Araştırma sonucunda; farelerdeki kanserli hücrelerin kemoterapiden daha az etkilendiği görüldü. 🔎Kullanılan rafine şeker ve beyaz un miktarını azaltmak; kandaki insülin ve IGFR düzeylerini hızla düşürüp kanser riskini de azaltır. Ayrıca daha sağlıklı bir cilde sağhip olmanızı sağlar. Ergenler arasında yapılan bir araştırma; üç ay, şeker ve beyaz un tüketimini kısıtlayanların insülin ve IGFR düzeylerinin yanı sıra aknelerinin de azaldığını kanıtladı. 🔎Glisemik endeksi yüksek olan besinler, meme kanserini tetikler. Yapılan bir araştırma; glisemik endeksi yüksek besinler tüketen hastaların ölüm oranının üçte bir olduğunu gösteriyor. 🔎Diyabet hastalarının kansere yakalanma oranları daha fazla. 50 yaşın altındaki kadınlar arasında yapılan bir araştırma; yüksek IGFR düzeyine sahip olanlarda, meme kanseri gelişmesi riskinin yedi kat fazla olduğunu ortaya koyuyor. -Prof.Dr.Erkan Topuz- #ciltgüzelliği #uyku #zayıflamakistiyorum #sağlıklıbeslenme #annesütü #yemek #estetik #ciltlekeleri #zayıflama #kiloalmakistiyorum #sağlıklıyaşıyoruz #bitkiseltedavi #sağlıklıbeslenme #kans (Yeni Yüzyıl Üniversitesi Gaziosmanpaşa Hastanesi) https://www.instagram.com/p/CFHsZBMh2QD/?igshid=pwxharz9u2yg

[carlbio]

Predicting Binding Affinity of Insulin Analogues

Binding Affinty of different Insulin analogues with IR and IGFR is predicted from our proteomics model. CA model parameters are estimated from three regions of Insulin- R1(9-19), R2(20-23), R3(24-30) - which include following structurally important regions - α-helix (B9–B19), a type I β-turn (B20–B23), and a C-terminal β-strand (B24–B28), followed by residues B29 & B30. The feasibility of disuphide bonds in insulin strcture is also predicted.

Analogue Binding with IR - Known Affinity Binding with IR - Predicted Affinity Binding with IGF1R – Known Affinity Binding with IGF1R – Predicted Affinity Insulin 100% 99% 100% 103.2% ASPART 92% 91% 81% 81.31% LISPRO 84% 83% 156% 153.4% B10ASP 205% 204% 587% 592.39% B12ALA 2% 3% - 0 B12THR 13% 12% - 88.52% GLULISINE 94% 92% - 105.78% GLARGINE 86% 88% 641% 509.1% 1B9E - Affinity Reduced 16% - 0 1HIS - 0 - 199.66% 1HIT - 0 - - 1JCO - Higher than INS 488% - 216.34% 1MHI - 0 - 0 1QJO -  Lower than INS 73% - 0 IGF1 0.2 0 - 0

Header image: Insulin in complex with Site 1 of the human insulin receptor (Menting, John G., et al. "Protective hinge in insulin opens to enable its receptor engagement." Proceedings of the National Academy of Sciences 111.33 (2014): E3395-E3404.)

[dreadloxholmes]

On top of the mountains overlooking @ Le Lac Des Peirou #lelacdespeirou #stremydeprovence #provence #vincentvangogh #escapefromthecity #breathfreshair #outdoorlife #takingabreak #holidays #landscapes #igersfrance #igfr #vacances #france #soirée #provenceeprintemps #relax (at Provence-Alpes-Cote d'Azur, France)