#hyaluronan

[teckinsight]

Joint Genesis

Feeling stiff or achy? Joint Genesis is your key to staying active and pain-free! 🌟 Featuring Mobilee®, it boosts hyaluronan for better joint lubrication and mobility. Inspired by Yuzurihara’s secret to healthy aging, Joint Genesis reduces inflammation and supports cartilage health.

Take the first step to healthy joints today! 🌿

[cudo29]

細胞間を結び付��ている結合組織を構成する重要成分の一つ「ヒアルロン酸」を分解する酵素のお話です。この分解は材料をリサイクルするために行われますが、がんの転移や細菌の感染、精子細胞と卵子の受精などその他さまざまな場面でも見られます。また蜂毒などにもこの種の分解酵素が含まれています。

詳しくは今月の分子「291: ヒアルロニダーゼ（Hyaluronidases）」をご覧ください。

日本語訳（PDBj）

This article refers to enzymes that break down hyaluronan, a key component of connective tissue for connecting cells. This degradation is aimed at material recycling but is also performed for cancer metastasizing, bacteria infection, and fertilizing of sperm cells and eggs. Moreover, bee venom includes this type of enzyme too.

For details, please refer to the Molecule of the Month article 291: Hyaluronidases

Original English Article（RCSB PDB）

[money786]

Joint Genesis: Unlocking the Secrets of Ageless Joint Health

[siglerprescriptiondrugcards]

Ocean

Ingredient: Sodium chloride, hyaluronan.

Dosage Form:

Ocean Spray: Sodium chloride 0.65%.

Ocean for Kids: Sodium chloride 0.65% with glycerin.

Ocean Gel: Contains purified water, glycerin, carbomer 940, trolamine, hyaluronan, methylparaben, and propylparaben.

Ocean Complete Sinus Rinse: Contains purified water, glycerin, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, potassium chloride, calcium chloride, and magnesium chloride.

Ocean for Kids Saline Nasal Spray: Contains 0.65% sodium chloride, purified water (USP), glycerin, phenylcarbinol, sodium phosphate monobasic, sodium hydroxide, and benzalkonium chloride.

FDA Indication/Dosages:

To restore moisture and relieve dry, crusted, and inflamed nasal membranes due to colds, low humidity, nasal decongestant overuse, allergies, minor nose bleeds, intranasal and endoscopic sinus surgery, and other irritants (Ocean Spray): Two sprays in each nostril as needed.

To irrigate nasal passages and sinuses (Ocean Complete): Using the orange tip, insert into the nostril and spray for one second. Gently inhale as you spray. Use two sprays in each nostril once per day. Use the white applicator tip to moisturize nasal passages.

To relieve dry skin in and around the nose (Ocean Gel): Apply as often as needed.

Pharmacology: Ocean spray is a pseudo-isotonic solution which helps to draw moisture from the body into the nasal cavity. This effect helps to rehydrate the nasal mucosa. The exact mechanism by which topical saline works for nasal congestion is not clear. It may be related to its hypotonic properties which may decrease inflammation by drawing fluid out of the tissues into the nasal cavity. The fluid can then be swallowed, removing debris, and improving ciliary function. It does not cause rebound nasal congestion therefore it is safe to use for more than three days. It is the preferred topical agent for use in infants and young children and in pregnant and nursing women. Hyaluronan is a carbohydrate polymer found in many human tissues. It is included in some of these products to increase hydration of mucous membranes.

Evaluation: Nasal mucosa can become dry and irritated due to low humidity, antihistamine use, nasal decongestant use, and other irritants. This can result in localized pain and nose bleeds. Allergies and the common cold are caused by different mechanisms, but the symptoms associated with each are similar. Allergies of the upper respiratory tract are caused by antibody-mediated reactions to inhaled antigens. The common cold is caused by any number of viruses. Allergies may occur year-round or during seasons in which the offending antigen is present. One of the major symptoms of both is nasal congestion. Other symptoms may include rhinitis, sneezing, conjunctivitis, cough, or pharyngitis.

Contraindications/Precautions: There are no contraindications to this medication. Do not aspirate nasal contents back into the bottle.

Adverse Effects: Sneezing, stinging, and watery eyes.

Patient Consultation:

Do not aspirate nasal contents back into the bottle.

Rinse and dry the tips of the applicators and spray bottles.

Ocean Complete and Ultra Sprays are under pressure and should not be punctured or incinerated.

Prolonged congestion may be a sign of a more serious condition. Consult a physician if symptoms do not improve within 10 days.

[yeshealthplease]

Study shows hyaluronan is effective in treating chronic lung disease

Study shows hyaluronan is effective in treating chronic lung disease

The research shows that inhaling hyaluronan interferes at almost every step of the COPD cycle, making it a potent treatment for chronic lung disease. Credit: Stavros Garantziotis, M.D. Researchers at the National Institutes of Health and their collaborators found that inhaling unfragmented hyaluronan improves lung function in patients suffering from severe exacerbation of chronic obstructive…

[biotulinsupremeskingel]

Hyaluronan vs. Botox®

Hyaluronan vs. Botox®

A comparison of the two most popular wrinkle treatments

Botox® is probably the most prominent wrinkle treatment around. Not only Hollywood stars are completely hooked on the neurotoxin that promises to keep the wrinkles in check and slow down the visible ageing process. The world over it is the number one cosmetic procedure. However, not everyone wants to exchange wrinkles for a motionless face. Hence, hyaluronan, also known as hyaluronic acid, presents itself as a great alternative as it does not paralyse the muscles. Both Botox® and hyaluronic acid are highly effective. To help you pick the right solution for you, we took a close look at both wrinkle treatments in detail.  Origins and production of the two most prominent ways to smoothen your face

Botulinum toxin

Botox® is actually a brand name. The drug that is injected under the skin is called botulinum toxin type A. It is a bacterial toxin. It was originally discovered in sausage cans that had been stored too long. Although it is often claimed that botulinum toxin is a snake venom, this is just a myth. Botulinum toxin is a drug made from a toxin produced by the bacterium clostridium botulinum.

Hyaluronan

Hyaluronan or hyaluronic acid is a polysaccharide that occurs naturally and can be found almost everywhere in the human body. It is a transparent, gel-like substance that makes the skin elastic and is responsible for its resilience. In the synovial fluid, it serves as a lubricant and is also found in the bones, intervertebral discs, as well as the vitreous body of the eye. Hyaluronic acid can be produced using biotechnological processes (vegetarian hyaluronan) but it can also be extracted from rooster combs.

Areas of application of botulinum toxin and hyaluronan

Botulinum toxin Botulinum toxin is not only used to combat wrinkles, but is also used in clinical medicine. It is a versatile clinical tool for a number of conditions such as twitching eyelids, chronic headaches or muscle cramps. It can even help excessive sweating when injected into the armpits, blocking the nerves that cause sweating. Botulinum toxin type A weakens and even paralyses muscles and is also able to block nerves, so that muscles can no longer be contracted. Cosmetic uses for botulinum toxin type A include the treatment of strong expression lines such as squint lines at the corners of the eyes (crow’s feet), the vertical lines between the eyebrows (also known as glabellar lines or forehead furrows) as well as nasolabial folds around the mouth. Hyaluronan In orthopaedic medicine hyaluronic acid is used to help combat osteoarthritis amongst other fields of applications. In aesthetic medicine hyaluronic acid is used for breast, butt and lip augmentation, and is an extremely popular dermal filler to combat wrinkles. Hyluronan is the ingredient of choice in anti-ageing creams and serums. Unlike botulinum toxin, hyaluronan does not inhibit the natural movements of the face. Its ability to store large amounts of water supplies the skin with moisture, which visibly rejuvenates the skin and gives it that extra fresh look. Sometimes hyaluronic acid and botulinum toxin type A are used in combination in order to combat particularly pronounced wrinkles. Whilst the paralysing effect of botulinum stops the movement of the face causing the deepening of the facial lines, hyaluronan is used as a dermal filler to fill in the existing wrinkles.

How long do Botox® and hyaluronan last?

Botulinum toxin Some 2-3 days after the treatment first effects become visible. However, it takes some 1-2 weeks for botulinum toxin type A to unfold its full effect, peaking at 10 days. The paralysing effect wears off over time. How fast this happens differs from patient to patient. Generally it takes about 4-6 months before you will need to be injected again if you wish to continue treatment. Hyaluronan The effect of hyaluronic acid, when injected, lasts about 6-9 months before it is fully metabolised by the body. However, it also depends on the type of hyaluronic acid used, which in turn depends on the depth of the wrinkles and the skin type of the patient. The effect of the treatment is visible immediately. If hyaluronic acid is used as an ingredient in anti-ageing creams and serums, it totally depends on the product. While some products visibly rejuvenate the skin as quickly as one hour after its application, others have to be used for weeks or even months, before any results become visible.

How much do Botox® and hyaluronic acid treatment cost?

Botulinum toxin The price depends on various factors: the quantity that needs to be injected, the doctor performing the treatment (the more prominent the doctor - or his patients - the more expensive) and the product/brand used. The price of the treatment starts from € 200. The price of botulinum toxin type A is calculated in units. Some 15 units are needed to combat crow’s feet, whilst about 20 units might be necessary for forehead wrinkles. Each unit costs approx. €12-18. Hyaluronan Hyaluronic acid is calculated in millilitres. 1 ml costs about € 350-400, depending on the manufacturer. The deeper the wrinkles, the more hyaluronan needs to be injected. While only about 0.5 ml of hyaluronic acid are needed for upper lip wrinkles or chin folds, a cheek augmentation requires 3 ml, making it much pricier. For external use, you can also go for anti-wrinkle creams and serums that are applied to the surface of the skin. They differ in price, depending on the manufacturer. For both botulinum toxin and hyaluronic acid, cheaper is never better. Extremely cheap deals can mean that the products used are unauthorised and illegal, which can have serious medical consequences.

Side effects - Looking younger and wrinkle-free may come at a higher cost than you are willing to pay

Botulinum toxin Botulinum toxin type A is considered the strongest lethal toxin and can even used as a bio-weapon. Hence, getting your wrinkles treated with this neurotoxin can have undesired side effects. It is therefore of utmost importance that you seek professional advice from a specialist before undergoing treatment. Typical but less dramatic side effects include mild swelling, haematomas and redness at the puncture site. The injection itself can cause a slight burning sensation. In case of an overdose or if botulinum toxin enters the bloodstream, the patient may get a dry mouth, headache and nausea, dysphagia and even respiratory muscle paralysis may occur. In such a case, an antiserum must be administered immediately. The patient must be ventilated artificially, as it takes a while for the antiserum to work. Celebrity Botox-Disasters But that is not all. Doctors do not have 100% control over where the botulinum toxin goes, once injected under the skin. If injected too close to the eyelid or if the doctor is not very experienced, you can end up with a droopy eyelid, an asymmetrical appearance or a “frozen face”. Bad news is: there is no antidote for badly injected botulinum toxin, you just have to wait until it wears off. Hyaluronan As with botulinum toxin, hyaluronic acid may also cause harmless side effects such as mild swelling, haematomas and temporary redness at the puncture sites. In the short term, hyaluronic acid dermal fillers can lead to a slightly stronger swelling or even nodule formation. However, these typically disappear within a few hours or days. Since hyaluronic acid is an endogenous substance, allergic reactions are highly unlikely but can occur. The success of a hyaluronic acid treatment depends on the skills and experience of the doctor who performs the treatment. The more experienced he/she is, the more beautiful and natural the result. When hyaluronic acid is applied externally, as a cream or serum, allergies or side effects are virtually unheard of, unless you are allergic to any of the other ingredients of the product you apply. You should not have injections of either botulinum toxin type A or hyaluronic acid when pregnant or breastfeeding.

So which one to pick? Are both wrinkle treatments equally effective?

Both botulinum toxin and hyaluronic acid live up to their promise. They will both help you achieve that younger look, stop new wrinkles and can reduce even deep expression lines. Although hyaluronic acid is slightly more expensive, it is definitely the safer option. Instead of having hyaluronic acid injections, it can also be applied externally as an ingredient of an anti-wrinkle skin care cream or serum. You can easily incorporate the application into your morning or evening routine. It is much less costly and has even fewer side effects than an injection. No matter what you decide: Given the numerous and sometimes serious side effects of botulinum toxin, you should consult with a qualified medical practitioner before you seek treatment. By the way, beauticians and estheticians are not legally allowed to inject botulinum toxin in Europe, only licensed people are. Regulations are less strict on the use of hyaluronic acid, however, given the damage you can do by injecting it wrongly, you better seek an equally trained medically trained individual as you would with botulinum toxin. Alternatively, you can always use an anti-wrinkle cream or serum that gives you the smoothing effect without side-effects.  Read the full article

[jamieduke123]

【Selfie】with 2.5 ml Hyaluronan injections my skin looks flawless LOL #flawless #love #hyaluronanacid #Hyaluronan #selfie #white #skin #eyes #eyebrows #makeup #VSCO #notfiltered #gay #LGBTQ+ #hot #red #lipgloss （在 Kunming, Yunnan） https://www.instagram.com/jamie_duke_/p/BwVsgktBUmf/?utm_source=ig_tumblr_share&igshid=1gh9na5dnat3z

[med-kb]

Sodium-Hyaluronate-based-injection-with-CE-for.jpg The average 70 kg (154 lb) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day. Hyaluronic acid has been used in attempts to treat osteoarthritis of the knee via injecting it into the joint. It has not been proven, however, to generate significant benefit and has potentially severe adverse effects.

[steveroser]

Price:$35.00, SKU:NW19655, Brand:Nature's Way, Size:60 vcaps

Dec  :

Hydraplenish contains low molecular hyaluronic acid with its exclusive BioCell Collagen II complex. This hyaluronic acid supplement is highly absorbed in the digestive tract producing more efficient joint support and connective tissue strength. Hyaluronic acid is the fluid found in the joints and connective tissues that acts as lubricant and cushion to prevent wear and tear. visit us http://www.tasmanhealth.co.nz/natures-way-hydraplenish/ for more details!!

[rilliaharvey]

As it turns out they, have a beauty secret that anyone can steal. When I explained to the salesperson that I needed them for the plane, he stopped in his tracks and said, “What you really need is Peter Thomas Roth ViZ-1000 with hyaluronic acid. It’s what every flight attendant who comes in here buys.

[majesticcosmevietnam]

🎀 Dành cho Nàng điều trị 𝑳𝒊𝒈𝒉𝒕 𝑷𝒆𝒆𝒍 🎀 Nếu bạn đang có ý định sử dụng liệu trình 𝑳𝒊𝒈𝒉𝒕 𝑷𝒆𝒆𝒍 thì đây là sản phẩm giúp bạn tăng gấp 3 lần hiệu quả của điều trị. Sau khi làm 𝑳𝒊𝒈𝒉𝒕 𝑷𝒆𝒆𝒍, da bạn cần tiếp thêm rất nhiều dưỡng chất, mà cách thông thường là tiêm trực tiếp HA (Hyaluronic Acid), Tế bào gốc... Tuy nhiên, bạn thì không muốn tiêm chích, hay chi trả quá nhiều cho filler. Thì 𝐌𝐚𝐣𝐞𝐬𝐭𝐢𝐜 𝐒𝐤𝐢𝐧 là giải pháp thích hợp cho bạn. 🌺 𝐌𝐚𝐣𝐞𝐬𝐭𝐢𝐜 𝐒𝐤𝐢𝐧 là serum Trẻ hóa da với 𝟐𝟎% #Tế_bào_gốc_từ_người 🧬, sẽ cung cấp một lượng lớn protein - Nguyên sợi bào (𝐅𝐢𝐛𝐫𝐨𝐛𝐥𝐚𝐬𝐭𝐬) + 𝟏𝟓𝟎 𝐆𝐫𝐨𝐰𝐭𝐡 𝐅𝐚𝐜𝐭��𝐫 (EGF, VEGF, TGF, IGF, FGF….). ✨ 𝐅𝐢𝐛𝐫𝐨𝐛𝐥𝐚𝐬𝐭𝐬 ALIVE này sẽ kích hoạt mạnh mẽ sản sinh #Collagen, #Elastin & #Hyaluronan “đang ngủ quên” dưới da của bạn để nâng đầy khung đàn hồi và làm phẳng mịn các vị trí bị sẹo mụn hay chùn xuống của nếp nhăn trên gương mặt. Và tăng cường độ ẩm mượt cho da. ✨Cho da bạn tới 𝟏𝟓𝟎 𝐆𝐫𝐨𝐰𝐭𝐡 𝐅𝐚𝐜𝐭𝐨𝐫 (nhiều gấp 𝟏𝟎 𝐥𝐚̂̀𝐧 so với các serum dưỡng khác), giúp tái tạo da khỏe mới, làm căng mướt và trắng sáng da. 👉 Dùng thử tại: bit.ly/31Uhi8X ~~~~~~~~~~~~~~~~~~~~~~~~~~ Đ𝔢̣𝔭 𝔩𝔢̂𝔫 𝔪𝔬̂̃𝔦 𝔫𝔤𝔞̀𝔶 𝔠𝔲̀𝔫𝔤 ⛩ 𝐌𝐚𝐣𝐞𝐬𝐭𝐢𝐜 𝐂𝐨𝐬𝐦𝐞 ⛩ ☎️ 𝟎𝟗𝟎 𝟏𝟐𝟔 𝟗𝟏𝟏𝟗 💻 www.vn-majesticcosme.com https://www.instagram.com/p/CHsW__Wp_Ks/?igshid=7imo9warb0dc

[visual-science-blog]

Frank is singing about hyaluronic acid in his skin

[jamieduke123]

【Selfie】sunset in Kunming selfie , lovely time for selfies. And I just got my Hyaluronan injections for nose sides. Ahhhhhh #Hyaluronan #injections #spring #summer #H&M #Bang&Olufsen #BeoPlayH9i #headphones #nofilters #kunming #gay #LGBTQ+ #shirt #walking #selfie https://www.instagram.com/jamie_duke_/p/BvoY44_BoVw/?utm_source=ig_tumblr_share&igshid=14mzoa7wqdgmi

[computermagazine]

Hyaluronan: New Cause of Epilepsy Discovered

Hyaluronan: New Cause of Epilepsy Discovered

Deficiencies in hyaluronan, a substance that occurs naturally inside the body and attracts water molecules, can lead to spontaneous epileptic seizures, according to a new study published in the April issue of the Journal of Neuroscience. Hyaluronan, also called hyaluronic acid or hyaluronate, is a polysaccharide molecule widely distributed throughout connective, epithelial, and neural tissues,…

[ctesthetic]

Hyaluronan Your Skins Best Friend!

Hyaluronan Your Skins Best Friend!

What is it?

Hyaluronan (also called hyaluronic acid or hyaluronateor HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions. One of the…

[biochemistries]

Able to live for decades (up to 32 years compared to the mouse's 3-4), the extremely wrinkly and extremely cancer resistant naked mole-rat turns out to derive its longevity from the very molecule that makes its saggy skin so able to stretch into tight underground burrows.

Hyaluronan (HA) is found throughout the body, interacting with a cadre of proteins that crosslink and bundle HA into unique structural and supermolecular complexes in the glycocalyx, or pericellular coat (PCC).

Involved in development, tissue homeostasis and disease, HA is particularly important in the early stages of cell adhesion, hence its role in cancer cell metastasis.

Writing in Nature, the group detail the five-fold greater HA secretion in naked mole-rat fibroblasts, its robust synthesis and slow degradation, a unique HA synthase sequence and the rodents' (twofold) higher affinity to HA than humans or mice (showing heightened sensitivity of the naked mole-rat cells to HA signalling).

Other anticancer features were noted, such as early contact inhibition (ECI) occurring at much lower density than in mice. The breakthrough came when naked mole-rats not displaying ECI were found to show no increase in culture media viscosity (already noted as coming from high HA concentration), since they lack this crucial extracellular signal. 

The protein is generally expressed in mammals, and offers definite encouragement for future drug targets in humans. In closing, they propose:

Using naked mole-rat HMM-HA in the clinic or targeting HYAL2, or the HA–CD44 signalling pathway, opens new avenues for cancer prevention and life extension.

Tian et al., "High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat". Nature, doi:10.1038/nature12234 (2013).