#hyaluronan

[cudo29]

細胞間を結び付けている結合組織を構成する重要成分の一つ「ヒアルロン酸」を分解する酵素のお話です。この分解は材料をリサイクルするために行われますが、がんの転移や細菌の感染、精子細胞と卵子の受精などその他さまざまな場面でも見られます。また蜂毒などにもこの種の分解酵素が含まれています。

詳しくは今月の分子「291: ヒアルロニダーゼ（Hyaluronidases）」をご覧ください。

日本語訳（PDBj）

This article refers to enzymes that break down hyaluronan, a key component of connective tissue for connecting cells. This degradation is aimed at material recycling but is also performed for cancer metastasizing, bacteria infection, and fertilizing of sperm cells and eggs. Moreover, bee venom includes this type of enzyme too.

For details, please refer to the Molecule of the Month article 291: Hyaluronidases

Original English Article（RCSB PDB）

[money786]

Joint Genesis: Unlocking the Secrets of Ageless Joint Health

[phonemantra-blog]

The Benefits of Hyaluronic Acid Supplementation At [Your Company Name], we understand the importance of providing you with accurate and comprehensive information. In this article, we will delve into the topic of hyaluronic acid supplementation and its numerous benefits. Our goal is to provide you with the highest quality content that will help you outrank other websites and ensure you have the knowledge you need. The Role of Hyaluronic Acid Hyaluronic acid is a naturally occurring substance in the human body, primarily found in the skin, eyes, and connective tissues. Its main function is to retain moisture, keeping tissues well-lubricated and hydrated. As we age, the production of hyaluronic acid decreases, leading to dryness, wrinkles, and joint discomfort. Improved Skin Health One of the most well-known benefits of hyaluronic acid supplementation is its positive impact on skin health. By replenishing the body's hyaluronic acid levels, supplementation can help improve skin hydration, elasticity, and overall appearance. Studies have shown that hyaluronic acid can reduce the appearance of fine lines and wrinkles, making it a popular ingredient in many skincare products. Joint Health and Mobility In addition to its benefits for the skin, hyaluronic acid also plays a crucial role in joint health. It acts as a lubricant and shock absorber, allowing joints to move smoothly and reducing discomfort. Supplementation with hyaluronic acid has been shown to improve joint mobility and reduce symptoms of conditions such as osteoarthritis. Eye Health Hyaluronic acid is also present in the eyes, where it helps maintain moisture and lubrication. Dry eyes can be a common problem, especially as we age. By supplementing with hyaluronic acid, individuals may experience relief from dryness and discomfort, leading to improved eye health and comfort. Choosing the Right Hyaluronic Acid Supplement When considering hyaluronic acid supplementation, it is important to choose a high-quality product. Look for supplements that are made from pure and bioavailable sources, ensuring maximum absorption and effectiveness. Additionally, consider the dosage and follow the recommended guidelines provided by the manufacturer or consult with a healthcare professional. [caption id="attachment_69926" align="aligncenter" width="640"] benefit of hyaluronic acid supplementation[/caption] Hyaluronic acid supplementation offers numerous benefits for skin health, joint mobility, and eye comfort. By replenishing the body's natural levels of hyaluronic acid, individuals can experience improved hydration, reduced wrinkles, enhanced joint function, and relief from dry eyes. Remember to choose a reputable supplement and follow the recommended dosage for optimal results. At [Your Company Name], we are committed to providing you with the highest quality information to help you make informed decisions about your health and well-being. Frequently Asked Questions 1. What is hyaluronic acid? Hyaluronic acid is a substance naturally produced by our bodies that helps keep our tissues lubricated and moist. 2. How does hyaluronic acid supplementation benefit the skin? Supplementing with hyaluronic acid can help improve skin hydration, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. 3. Can hyaluronic acid supplementation help with joint pain? Yes, hyaluronic acid supplementation has been shown to provide relief for joint pain by lubricating the joints and reducing inflammation. 4. Are there any side effects of hyaluronic acid supplementation? Hyaluronic acid supplementation is generally safe and well-tolerated. However, some individuals may experience mild side effects such as headaches or digestive issues. 5. How long does it take to see the benefits of hyaluronic acid supplementation? The time it takes to see the benefits of hyaluronic acid supplementation can vary depending on the individual. Some people may notice improvements in their skin or joint pain within a few weeks, while others may take longer. 6. Can hyaluronic acid supplementation help with dry eyes? Yes, hyaluronic acid eye drops or supplements can help alleviate dry eyes by providing lubrication and promoting tear production. 7. Is hyaluronic acid supplementation suitable for all ages? Yes, hyaluronic acid supplementation can be beneficial for individuals of all ages who want to improve their skin hydration, joint health, or overall well-being. 8. Can I take hyaluronic acid supplements while pregnant or breastfeeding? It's always best to consult with your healthcare provider before taking any supplements while pregnant or breastfeeding to ensure safety and suitability. 9. Can hyaluronic acid supplementation replace a healthy skincare routine? No, hyaluronic acid supplementation should be considered as a complementary addition to a healthy skincare routine, which includes proper cleansing, moisturizing, and sun protection. 10. Where can I find hyaluronic acid supplements? Hyaluronic acid supplements are available in various forms, including capsules, tablets, and liquid. They can be found at most health food stores, pharmacies, or online retailers.

[healthwellwisher]

VisiSoothe Review - Dry Eye Relief

Product Name — VisiSoothe

Structure – Natural Product for Dry Eye Relief

Benefits – Ultimate Solution for Dry Eye Relief

Aftereffects — NA

Accessibility — Online

Rating — 5/5

Official Website (Sale Is Live) ⤖ Click Here to Order Now

Odd but true, our eyes are the sense that is most often neglected. We continued to ignore them until our students were overworked or stressed out. We can all agree that our vision is the most crucial aspect of our day-to-day operations.

What is VisiSoothe?

A dietary supplement called VisiSoothe aids in maintaining and enhancing general eye health.

VisiSoothe was created specifically to safeguard your vision. This guarantees that you keep taking in the beauty of the environment around you. It has a combination of organic ingredients that enhance your vision and guard against developing eye issues.

<<<You can order VisiSoothe from the official website>>>

Eye damage, which can cause weak eyes or decreased vision, often affects elderly people owing to deficiencies and is linked to ageing. VisiSoothe can prevent vision loss and enhance eye function, according to the product's manufacturer.

VisiSoothe is made up of 24 natural ingredients, each of which adds something significant to the product, such as effective cleansing, defence against pollutants and toxins, and removal of cellular waste and free radicals from the body.

In the end, the long-term effects result in a recovery of vision and an improvement in ocular health. The supplement may improve your vision while also helping to treat eye infections, even those that are present near the retina.

VisiSoothe  :  How Does Work?

VisiSoothe is intended to treat declining eyesight and enhance mental clarity. It includes organic ingredients designed to help meet the nutritional needs of the eyes and support eye renewal and vision restoration.

Age-related macular degeneration, or AMD, is one of the most uncomfortable consequences of ageing. VisiSoothe, which contains a special blend of crucial nutrients, can help treat this illness.

These elements can enhance both the retina's functionality and the eye's overall health. As a result, VisiSoothe is marketed as a complete treatment for a variety of eye problems.

VisiSoothe offers a straightforward anti-vision loss medication in the form of pills. Each container comes with sixty capsules, each of which should be taken once a day. They ought to see observable improvements in their visual acuity.

VisiSoothe produces dietary supplements that are advantageous for anyone over the age of 18. But, if you are expecting or breastfeeding, you shouldn't use this supplement. Also, you should check your doctor before using it if you are taking prescription medicine or receiving treatment for certain medical conditions.

<<<You can order VisiSoothe from the official website>>>

Ingredients

Warrigal Spinach - Many studies have shown that spinach in whatever form has two special vitamins that have a significant impact on eye health.

According to clinical studies, those vitamins are absolutely necessary for treating macular degeneration, cataracts, and other age-related eye diseases like glaucoma.

And guess what? Those antioxidants have been present in your eyes since the moment you were born!

Without them, our eyes cannot feature at all.

We wish to consume them from outside simply because our body can't manufacture it better.

Shellfish - DHA, the main structural component of the retina, has been linked to improved vision.

Kangaroo Meat - A seven-year medical study found that among 5400 patients who consumed it, there was a reduced risk of 34% of contraction.

Indigenous Koori fruits, vegetables, herbs, berries, seeds like pig wed seeds, plums, and other fruits and vegetables.

VisiSoothe Supplement is where you can find the entire mixture!

It is exclusively created from natural ingredients that have survived months of testing by experts and researchers.

There has never been a product like VisiSoothe in the history of eye care.

The 20/20 crystal clear vision that everyone needs is guaranteed with VisiSoothe.

VisiSoothe promises that you won't need any invasive procedures, eye workouts, or contact lenses.

It is the go-to solution for nourishing and cleaning your eyes to noticeably improve your field of vision.

This novel herbal remedy attacks the root cause and offers a permanent solution to all of your eye issues.

It provides the essential antioxidants that eliminate the damaging free radicals for your eyes.

Pros

VisiSoothe is a dietary supplement that calms the body internally and doesn't build habits.

The blend contains amounts of natural substances that have been professionally verified.

Using plant extracts, herbs, and other essential nutrients that cure the ocular system, VisiSoothe gives the body the nutrition it needs.

It is easier for people of all ages to use because it comes in the shape of an easy-to-swallow capsule.

<<<You can order VisiSoothe from the official website>>>

Together with improving your vision, the scientifically-proven mixture offers a number of other advantages.

Chemicals, poisonous substances, and other compounds that can cause unwanted effects are not present in VisiSoothe.

Cons

You may only purchase the item through VisiSoothe's official website; it is not available anywhere else.

It is crucial to monitor your eye health because it was not designed to replace any existing treatments or medications that you may be taking.

It has been suggested that you speak with a doctor before incorporating any new supplements into your regimen.

To use the recipe safely, it's critical to adhere to the suggested dosage.

The length of time it takes you to see noticeable benefits depends on consistency, how your body responds to the formula, and a number of other contributing factors.

Conclusion

A nutritional supplement for eye health called VisiSoothe encourages good vision and can help keep healthy eyesight as you age. VisiSoothe asserts that by utilising all-natural ingredients like antioxidants, vitamins, minerals, herbs, and nutrients, it can support your vision.

Although it has been stated by a number of sites, there is no proof to back up claims that VisiSoothe can change stem cells, correct blindness, or enhance eyesight. By combining a number of naturally occurring elements that are unique to this formulation, it may improve visual clarity.

More Info:-

[vat-avaran]

Immortal Invades Insidious: Naked mole rats live long, cancer-free lives.

Naked mole rats seem quite unappealing visually with their long bunny teeth and wrinkled skin. Other rodents might be kept in the adorable category, if we say so! However, their life span compared to other rodents and their way of resistance to age-related diseases could open new doors to Cancer and its treatment.

Naked mole rats are special for some fascinating facts:

Only cold-blooded mammal

Cannot feel pain through its skin

Eusocial like a couple of arthropods, one of only two mammals

can live in extremely oxygen-deprived conditions

Most importantly, IT NEVER GETS AFFECTED WITH CANCER.

Several studies were conducted on naked mole rats to find that a kind of "claustrophobia-induced gene" called p16 was activated in naked mole rats to stop the growth of cells if they become too tightly packed. This process can also be termed as contact inhibition which happens in other animals including us, humans. Contact inhibition is a phenomena which is anti-cancer and prevents abnormal growth and division of cells. In their case, contact inhibition is exhibited stronger by p16. But what is the reason behind this over sensitivity?

Recent findings suggest an answer in the form of a molecule secreted by the cells of naked moles called Hyaluronan. Hyaluronan is a polysaccharide (long beads of sugar) or glycosaminoglycan (GAGs) which are found in our extracellular matrix and this gluey substance is somehow, responsible for contact inhibition in naked moles so strongly.

But what made their hyaluronan different from ours?

Well, when the researchers analyzed, they found out that their hyaluronan is five times bigger than human's. This massive gooey chain of sugar inhibits the processes like division and inflammation which can be attributed to cancer.

Could cutting down the levels of Hyaluronan induce cancer?

Rats' cells were engineered by switching off a gene called p53 and switching on Ras gene, to make these affected by cancer. Cells with Hyaluronan repeatedly resisted while those whose Hyaluronan was ceased from being produced by gene manipulation of the enzyme Hyaluronidase, cells showed signs of tumour. Hence, it was concluded that this polysaccharide plays a key role in preventing Cancer in Naked mole rats.

This marvel can prove to be a breakthrough path in Oncology and Cancer Research.

Reference: https://news.cancerresearchuk.org/2013/06/20/another-clue-to-how-the-naked-mole-rat-stays-cancer-free/

[owlservice]

The naked mole rat has been endowed by natural selection with an exceptionally long life span among rodents (over thirty years) and has a very low cancer incidence (Tian et al. 2013). Given the relative lack of predators and other external hazards in the rats’ sealed underground burrows, natural selection favored prolonged investment in tissue maintenance because it paid off in terms of reproductive success through these long lives. In terms of cancer prevention, naked mole rat fibroblasts secrete a special form of the molecule hyaluronan, a major component of the extracellular matrix in many tissues that controls cell proliferation and migration. The hyaluronan produced by naked mole rat cells is of larger molecular weight than that in humans and mice, and it accumulates at high levels throughout the rat’s tissues. Cell culture experiments showed that manipulating hyaluronan could dictate transformability: removing this high molecular weight hyaluronan made the usually cancer refractory naked mole rat cells susceptible to transformation to a more cancer-like phenotype (Tian et al. 2013). The type of hyaluronan determined how cells responded to their neighbors, with the larger hyaluronan form in naked mole rats leading to cell division arrest when cells contact other cells. If these mechanisms function similarly in tissues during oncogenesis, species-specific differences in hyaluronan could contribute to differential cancer susceptibility. Notably, this mechanism so far appears unique to naked mole rats.

[sukimas]

(the short explanation for why absorbing hyaluronan from outside sources leads to its breakdown whereas producing it in the body doesn't is that the amounts of certain hyaluronidase enzymes are governed by how much hyaluronan is already in the blood rather than in the extracellular matrix. if there's a low amount as is normal, small amounts of hyaluronidase will be produced. if there's a high amount- such as when hyaluronan is absorbed into the skin, for example- more will be produced, and will even get into the extracellular matrix and break down HMW-HA there.)

[healthysupplementwithjessica]

Joint Genesis works by:

✅ Boosting Joint Lubrication: Mobilee® replenishes hyaluronan, enriching synovial fluid for smooth, pain-free movement.

✅ Supporting Cartilage Health: Nourishes cartilage, maintaining resilience and reducing stiffness.

✅ Managing Inflammation: Anti-inflammatory ingredients like French Maritime Pine Bark and Ginger Root reduce swelling and promote mobility.

This powerful combination addresses the root causes of joint discomfort, allowing users to stay active without limitations.

[kenyasurrogacy]

PICSI Treatment in Kenya

When it comes to advanced fertility treatments, PICSI (Physiological Intracytoplasmic Sperm Injection) is one of the groundbreaking procedures helping couples achieve their dream of parenthood. Kenya has emerged as a regional hub for fertility treatments, offering state-of-the-art medical facilities and expert care for procedures like PICSI.

What is PICSI?

PICSI is a specialized procedure used alongside In Vitro Fertilization (IVF) to enhance fertilization outcomes. It involves selecting the best quality sperm for fertilization by mimicking the natural selection process that occurs in the female reproductive system. The process uses a hyaluronan-coated dish to identify mature, healthy sperm that are more likely to result in successful fertilization and embryo development.

Who Can Benefit from PICSI?

PICSI is particularly beneficial for:

Couples with Male Infertility Factors: For men with poor sperm motility or morphology, PICSI increases the chances of using high-quality sperm.

Repeated IVF Failures: Couples who have experienced unsuccessful IVF cycles may see improved outcomes with PICSI.

Unexplained Infertility: PICSI helps in cases where the underlying cause of infertility is unclear, as it focuses on the selection of the most viable sperm.

Why Choose PICSI in Kenya?

Kenya is quickly becoming a leading destination for fertility treatments in East Africa. Here’s why PICSI treatment in Kenya is a viable choice:

World-Class Facilities: Fertility clinics in Kenya are equipped with the latest technology and follow international standards of care.

Experienced Specialists: Fertility experts in Kenya are highly trained, with vast experience in performing procedures like PICSI, IVF, and ICSI.

Cost-Effectiveness: Compared to treatments in other countries, the cost of PICSI in Kenya is more affordable, making it accessible to many couples.

Holistic Care: Clinics offer personalized treatment plans, ensuring that every patient receives care tailored to their specific needs.

What to Expect During the PICSI Procedure

The PICSI process is straightforward and performed as part of the IVF cycle:

Sperm Collection: A sperm sample is collected from the male partner.

Sperm Selection: Using a hyaluronan-coated dish, the most mature and healthy sperm are selected.

Egg Fertilization: The selected sperm is injected into the egg to facilitate fertilization.

Embryo Transfer: Once the embryos develop, they are transferred to the female partner’s uterus for implantation.

Start Your Journey to Parenthood

If you’re considering PICSI treatment in Kenya, our team is here to guide you every step of the way. We are committed to providing compassionate care and using cutting-edge techniques to help you achieve your dreams of starting or expanding your family.

For more information, email us at info@kenyasurrogacy.com or contact us at +254 100241479. Let us help you on your journey toward parenthood.

[mloosepowder]

Pilihan Terbaik! Moringa Sunscreen Mist Fabil, Sunscreen Spray Tanpa Whitecast untuk Kulit Terlindungi, WA/Call 0878-8544-9886

KLIK https://wa.me/6287885449886

Moringa Sunscreen Mist dari Fabil menghadirkan perlindungan optimal dalam bentuk sunscreen spray SPF 45 PA+++ dengan teknologi Encapsulated UV Filter. Dirancang untuk melindungi kulit dari sinar UVA & UVB tanpa meninggalkan rasa lengket atau whitecast, sunscreen semprot ini sangat ringan dan mudah menyerap di kulit. Tekstur ultra-fine mist-nya memastikan aplikasi sempurna yang tak akan merusak makeup, sehingga mudah untuk reapply kapan saja tanpa khawatir! Selain itu, formula non-aerosol yang bebas alkohol dan parfum ini menjadikannya aman bahkan untuk kulit sensitif dan anak-anak mulai usia 7 tahun.

Dilengkapi dengan 11 Multi Complex Hyaluronan, Moringa Sunscreen Mist menjaga kelembapan kulit sepanjang hari agar tetap segar dan terhidrasi, meskipun berada di bawah sinar matahari atau terpapar polusi. Sunscreen wajah dan tubuh ini menawarkan 4-in-1 Protection yang melindungi dari sinar UVA, UVB, Blue Light, dan polusi, sekaligus menjaga barrier kulit dari tanda-tanda penuaan dini, seperti kerutan dan garis halus. Untuk perlindungan optimal, semprotkan secara merata pada wajah dan tubuh setiap 2-3 jam.

Jadikan Fabil Natural Official Moringa Sunscreen Mist sebagai bagian dari rutinitas harian Anda untuk menjaga kulit dari berbagai efek negatif lingkungan! Temukan perlindungan dari fabil sun screen mulai dari sunscreen spray wajah SPF 50 PA++++ hingga travel-size sunscreen spray yang praktis. Cocok sebagai suncreen spray body dan sunblock wajah semprot, produk ini memberikan kenyamanan perlindungan sepanjang hari dalam bentuk sunscreen mist spray yang ringan dan menyegarkan.

Cara Pemakaian:

Kocok sebelum digunakan. Tutup mata dan tahan nafas, lalu semprotkan produk ke area wajah dan badan

Lakukan sebanyak 3-4 kali putaran untuk proteksi optimal

Ratakan produk dengan tepuk wajah dengan tangan

Gunakan setiap 2-3 jam sekali untuk reapply.

FABIL NATURAL Jl. Sholeh Iskandar No.3, RT.02/RW.11, Kedungbadak, Kec. Tanah Sareal, Kota Bogor, Jawa Barat 16164 Temukan Kami di Google Maps https://maps.app.goo.gl/A1LBEY2GVeHd9iGJ7 (Sebelah Rafita's Cake) FAST RESPON WA/Call 0857-1727-3710 Kunjungi Juga: https://fabil.co.id/ https://shopee.co.id/fabilofficialstore/ https://www.tokopedia.com/fabilofficialstore/ https://www.instagram.com/fabilnaturalofficial/ https://www.facebook.com/fabilskinstore/ https://www.tiktok.com/@fabilnaturalofficial/

[visionarycentreforwomen]

Discover the G-Shot®: A New Path to Pleasure

Did you know that there is such a thing as G-Spot Amplification® or, as it is more familiarly called, the G-Shot®? This form of innovation allows females to improve how they feel sexually. The G-Shot® treatment requires administration of hyaluronan to the G spot (Grafenburg spot). It also important to make the distinction between hyaluronan and collagen, the fundamental difference being that the former is a natural molecule present in our body and yams and fruits and such like. This it-get ingredient of health consists of balmy and protective properties to fortify sensitivity, and thereby upgrade touch. Dr. Hayes has recently appeared on Tampa Bay’s 10 Connects news segment to explain how the G-Shot® can help to enhance women’s sex lives. The hyaluronan utilized in the G-Shot® goes through bacterial fermentation thus making the hyaluronan pure and dependable.

Check out: G-Shot featured video

[skincarehalal]

Moringa Booster Body Yogurt dan Moringa Sunscreen Mist Terbaik untuk Kulit Sehat dari Fabil Natural, WA/Call 0878-8544-9886

KLIK https://wa.me/6287885449886

Saat ini, semakin banyak orang yang menyadari pentingnya merawat kulit dengan benar. Baik itu wajah maupun tubuh, kelembapan dan perlindungan menjadi kunci utama untuk menjaga kulit tetap sehat dan bercahaya. Jika kamu mencari produk perawatan kulit tubuh yang ampuh, Fabil Natural Official punya solusi terbaik untukmu.

Moringa Booster Body Yogurt Body yogurt yang diformulasikan untuk menjaga kelembapan kulit hingga 24 jam dengan kombinasi Shea Butter, Panthenol, dan 12x Hyaluronic Complex. Dengan 5x Brightening Complex, body yogurt ini membantu mencerahkan warna kulit tidak merata. Kaya antioksidan, formulanya melindungi kulit dari radikal bebas sekaligus menutrisi kulit agar tampak sehat dan kenyal. Tekstur ringannya cepat menyerap tanpa meninggalkan rasa lengket, memberikan kelembutan dan kesegaran yang tahan lama.

Mengapa Memilih Moringa Booster Body Yogurt?

5X Brightening Complex: Mencerahkan kulit belang dan tak merata secara bertahap.

Non-Sticky, Fast Absorbing Formula: Teksturnya yang ringan langsung meresap tanpa rasa lengket atau residu.

Moisture for 24 Hours: Dilengkapi 12x Hyaluronic Complex, Shea Butter, dan Panthenol untuk menjaga kulit tetap lembap.

Antioxidant Protection: Kaya antioksidan, melindungi kulit dari radikal bebas dan polusi.

Instant Glow & Soft Skin: Kulit terasa halus, lembut, dan tampak bercahaya sejak pemakaian pertama.

Hero Ingredients:

5% Niacinamide: Mencerahkan, mengurangi warna tak merata, dan menyamarkan bekas luka.

Rice Bran Oil + Licorice: Mencerahkan, melembapkan, dan melindungi kulit dengan antioksidan.

12x Hyaluronic Complex + Panthenol: Menjaga kelembapan, memperbaiki barrier kulit, dan memberikan efek plump sehat.

Ginseng Root: Menghidrasi kulit, meratakan warna, dan mengatasi tanda penuaan dini.

Shea Butter: Memperbaiki barrier kulit dan memberikan hidrasi mendalam.

Moringa: Mencerahkan dan menutrisi kulit dengan antioksidan dan vitamin.

Cara Pakai:

Oleskan pada tubuh setelah mandi atau kapan pun kulit terasa kering.

Usapkan secara merata sambil dipijat lembut hingga meresap.

Gunakan 2 kali sehari untuk hasil terbaik.

Moringa Sunscreen Mist Sunscreen mist dengan SPF 45 PA+++ dan teknologi Encapsulated UV Filter yang melindungi kulit dari sinar UVA & UVB. Dengan formula non-aerosol, sunscreen ini mudah digunakan tanpa menghapus makeup, memberikan perlindungan 4-in-1 (UVA, UVB, Blue Light, polusi udara). Dilengkapi 11 Multi Complex Hyaluronan yang memastikan kulit tetap lembap dan terlindungi sepanjang hari. Formula ringan tanpa whitecast dan aman digunakan untuk anak-anak.

Mengapa Memilih Moringa Sunscreen Mist?

Non-Aerosol, Alcohol-Free Formula: Aman untuk kulit sensitif dan anak-anak, tanpa parfum dan alkohol.

Encapsulated UV Technology: Formula ringan yang cepat menyerap tanpa whitecast atau rasa lengket.

4-in-1 Protection: Melindungi kulit dari UVA, UVB, Blue Light, dan polusi udara.

Ultra-Fine Mist: Memudahkan re-apply tanpa merusak makeup, cocok untuk wajah dan badan.

Dual Use for Face & Body: Bisa digunakan untuk area wajah dan tubuh, praktis untuk sehari-hari.

Cara Pakai:

Kocok sebelum digunakan. Tutup mata dan semprotkan ke wajah dan badan.

Lakukan 3-4 kali semprotan untuk perlindungan merata.

Tepuk-tepuk lembut untuk meratakan.

Re-apply setiap 2-3 jam untuk proteksi optimal.

Dengan Moringa Booster Body Yogurt dan Moringa Sunscreen Mist, Fabil Natural Official menghadirkan produk perawatan tubuh yang lengkap, dari kelembapan hingga perlindungan, yang tidak hanya efektif tapi juga aman untuk segala jenis kulit. Pastikan tubuhmu selalu terhidrasi dan terlindungi dengan rangkaian produk alami ini!

FABIL NATURAL Jl.Sholeh Iskandar №3. Kedungbadak, kec. Tanah sereal, RT.02/RW.11, Kota Bogor, Jawa Barat 16164 Temukan Kami di Google Maps https://maps.app.goo.gl/A1LBEY2GVeHd9iGJ7 (Sebelah Rafita’s Cake) FAST RESPON WA/Call 0878–8544–9886 Kunjungi Juga: https://fabil.co.id/ https://shopee.co.id/fabilofficialstore/ https://www.tokopedia.com/fabilofficialstore/ https://www.instagram.com/fabilnaturalofficial/ https://www.facebook.com/fabilskinstore/ https://www.tiktok.com/@fabilnaturalofficial/

[johnkhilll]

Key Player in the AGING of the skin is HYALURONIC ACID.

Synopsis

Intrinsic and extrinsic aging are two separate and independent mechanisms that contribute to the multifactorial process of skin aging. Because youthful skin has a high water content, it maintains qualities like turgor, resilience, and pliability. Moisture loss results from everyday external damage in addition to aging naturally. Hyaluronic acid (HA) is the primary molecule responsible for skin hydration because of its exceptional ability to hold onto water. The intricacy of HA metabolism is reflected in the various locations for control over HA production, deposition, cell and protein interaction, and destruction. The multigene families of enzymes that synthesis or catabolize HA and HA receptors, which are involved in numerous HA functions, have unique tissue expression patterns. The ability to rationally regulate skin moisture will be aided by knowledge of the metabolism of HA in the various skin layers and its interactions with other skin components.

Aging skin

Ageing of human skin is a complicated biological process that is still poorly understood. It is the outcome of two separate biological processes. The first is inherent aging, also known as intrinsic aging, which is an unavoidable process that affects all internal organs in the same pattern as the skin. Extrinsic aging, commonly known as photoaging, is the second type of aging that results from exposure to outside causes, primarily ultraviolet (UV) irradiation. Age-related hormonal changes, such as the steady decline in sex hormone production starting in the mid-20s and the reduction in estrogen and progesterone associated with menopause, can have an impact on intrinsic skin aging. It is commonly known that low levels of estrogens and androgens cause the skin to become dry, brittle, lose its suppleness, develop epidermal atrophy, and wrinkle.

Despite being different processes, intrinsic and extrinsic skin aging have similar molecular mechanisms. For instance, both activities heavily rely on reactive oxygen species (ROS), which are produced by oxidative cell metabolism. In both intrinsic and extrinsic skin aging, ROS trigger the transcription factor c-Jun through mitogen-activated protein kinases (MAPK), which in turn causes the expression of procollagen-1 to be inhibited and matrix metalloproteinase (MMP)-1, MMP-3, and MMP-9 to be overexpressed. Thus, diseases arising in intrinsically aged as well as photoaged skin include elevated amounts of damaged collagen and impaired collagen synthesis.

Loss of skin hydration is also linked to skin aging. Hyaluronan, also known as hyaluronic acid (HA), is a glycosaminoglycan (GAG) that plays a crucial role in skin hydration because of its exceptional ability to bind and hold onto water molecules. HA is a chemical found in the extracellular matrix (ECM). The components of the skin have been thoroughly defined in recent decades. The cells that make up the layers of skin, including the dermis, epidermis, and subcutis underneath, were the subject of the majority of early research. It has recently become clear that the extracellular matrix (ECM) molecules that exist between cells not only provide a useful framework but also have a significant impact on cellular activity. These extracellular matrix (ECM) components, which mostly consist of glycogen-binding proteins (GAG), proteoglycans, growth factors, and structural proteins like collagens, form a highly ordered structure despite seeming amorphous under light microscopy. But HA makes up the majority of the skin's extracellular matrix.

The involvement of HA in angiogenesis, reactive oxygen species, chondrocytes, cancer, lung damage, immunological modulation, and skin has been discussed in recent reviews. This review focuses on the role of HA in skin aging and provides a brief overview of recent findings in HA biology and function.

The hyaluronic acid 

Properties of chemistry and physicochemistry

As a non-sulphated GAG, HA comprises repeated polymeric disaccharides connected by a glucuronidic β (1→3) connection between D-glucuronic acid and N-acetyl-D-glucosamine. HA creates particular stable tertiary structures in aqueous solutions. HA possesses a wide range of physicochemical characteristics and a simple composition devoid of branching points or changes in its sugar content. HA polymers can take various forms and topologies based on pH, size, salt concentration, and related cations. Proteoglycans can form aggregates with HA, although HA is not covalently bound to a protein core like other GAGs. Even at low concentrations, HA gives solutions a high viscosity because it contains a lot of water.

Distribution of HA in tissues and cells

Widespread in both prokaryotic and eukaryotic cells is HA. Human HA is found in all bodily tissues and fluids, including skeletal tissues, heart valves, lung, aorta, prostate, tunica albuginea, corpora cavernosa, and corpus spongiosum of the penis. It is most prevalent in the skin, where it makes up 50% of the body's total HA, as well as the vitreous of the eye, the umbilical cord, and synovial fluid. Mesenchymal cells are the main source of HA, while other cell types can also make it.

HA's biological role

Significant research over the previous 20 years has shown the functional significance of HA in molecular pathways and suggested that HA may play a role in the creation of novel therapeutic approaches for a variety of disorders.

Hydration, joint lubrication, gap filling, and providing a framework for cell migration are among the functions of HA. Increased production of HA occurs during tissue damage and wound healing. HA controls multiple elements of tissue repair, such as the immunological response boosted by inflammatory cell activation and the fibroblast and epithelial cell response to injury. Moreover, HA offers the structural basis for fibroblast migration and blood vessel creation, both of which may aid in the development of tumors. It has also been documented that the aggressiveness of tumors is correlated with the amount of HA present on the cell surface of cancer cells.With regard to the several roles that HA plays that were previously mentioned, its magnitude seems to be crucial. Smaller polymers of HA are distress signals and strong inducers of inflammation and angiogenesis, while high molecular size HA, often over 1,000 kDa, is found in intact tissues and is antiangiogenic and immunosuppressive.

HA biosynthesis

HA synthases (HAS) are specialized enzymes that produce HA. These enzymes are membrane-bound, producing HA on the plasma membrane's inner surface, which is subsequently extruded into the extracellular space through pore-like structures. Three mammalian enzymes, HAS -1, -2, and -3, are known to generate HA chains of different lengths and display unique enzymatic characteristics.

HA degradation

HA's rate of turnover is dynamic. The half-lives of HA in the blood are 3 to 5 minutes, in the skin they are less than a day, and in cartilage they are 1 to 3 weeks. Hyaluronidases (HYAL) hydrolyze the hexosaminidic β (1–4) links between N-acetyl-D-glucosamine and D-glucuronic acid residues in HA, breaking it down into fragments of different sizes. Six HYAL have been found in humans thus far: PH-20, HYAL-1, -2, -3, -4, and HYALP1. Because the HYAL enzyme family is found at very low quantities and is challenging to purify, define, and quantify due to its high yet unstable activity, it has gotten little attention until recently. HYAL has now been able to be isolated and characterized thanks to new protocols. The predominant HYAL in serum is HYAL-1. Mucopolysaccharidosis type IX and HYAL deficiency are linked to mutations in the HYAL-1 gene. Compared to plasma HYAL-1, HYAL-2 exhibits much lower activity. It hydrolyzes mostly high molecular weight HA, producing HA fragments that are about 20 kDa in size. PH-20 then further breaks these fragments down into tiny oligosaccharides. In addition to other organs including the human lung, the bone marrow and testis are the primary sites of HYAL-3 expression. It has been proposed that HYAL-3 may aid in the breakdown of HA by increasing HYAL-1's activity, albeit its precise function in the catabolism of HA is unknown.

In the presence of reducing agents such ascorbic acid, thiols, ferrous, or cuprous ions, HA can also be broken down non-enzymatically through a free-radical mechanism; this process necessitates the presence of molecular oxygen. Therefore, it can be helpful to apply agents that can postpone the HA's destruction caused by free radicals in order to preserve the integrity of dermal HA and its moisturizing qualities.

Hormone-like acid receptors

Hyaladherins are a class of proteins that bind to HA and are found in the cytoplasm, nucleus, cell surface, and extracellular matrix (ECM). HA receptors are those that bind HA to the surface of cells. The transmembrane glycoprotein "cluster of differentiation 44" (CD44), which is produced by a single gene with variable exon expression, is the most well-known of these receptors. It exists in several isoforms. With the exception of red blood cells, almost all cells have CD44 on them. It controls metastasis from cancer as well as cell adhesion, motility, lymphocyte activation, and homing.

Another important HA receptor that is expressed in different isoforms is the receptor for HA-mediated motility (RHAMM). Numerous cell types, including endothelial cells and smooth muscle cells from the pulmonary arteries and airways of humans, have functional receptors for RHAMM. Through a complex network of signal transduction processes and connections with the cytoskeleton, the interactions between HA and RHAMM regulate cell growth and migration. The synthesis and expression of RHAMM and HA are triggered by the powerful cell motility stimulant, transforming growth factor (TGF)-β1, which also starts the process of locomotion.

Skin's hyaluronic acid

The application of biotinylated HA-binding peptide demonstrated that HA may be synthesized by cells other than those of mesenchymal origin and allowed HA to be histolocalized in the skin's dermal compartment and epidermis. With the use of this approach, it was possible to see HA in the epidermis, primarily in the top spinous and granular layers' extracellular matrix (ECM), while HA is primarily intracellular in the basal layer.

The skin's ability to act as a barrier is partially ascribed to structures known as lamellar bodies, which are believed to be altered lysosomes that contain hydrolytic enzymes. They can partially change their polar lipids into neutral lipids and acidify through proton pumps when they unite with the mature keratinocytes' plasma membranes. These lipids are produced by keratinocytes in the stratum granulosum and prevent aqueous material from diffusing through the epidermis. The amount of HA staining correlates with this border effect. Water from the moisture-rich dermis may be absorbed by the HA-rich area under this layer, but it cannot pass through to the lipid-rich stratum granulosum. Skin hydration is primarily dependent on the stratum granulosum, but it is also crucially dependent on HA-bound water in the dermis and the important portion of the epidermis. Dehydration brought on by a significant loss of stratum granulosum in burn patients might result in major clinical issues.

As was already noted, the majority of the body's total HA is found in the skin. The dermis has a substantially higher HA content than the epidermis, and the papillary dermis has a much higher HA content than the reticular dermis. The vascular and lymphatic systems are continuous with the dermal HA. In the dermis, HA improves the extracellular domain of cell surfaces, controls ion flow, osmotic pressure, and water balance. It also acts as a sieve, filtering out certain molecules and stabilizing skin structures through electrostatic interactions. Prolonged presence of HA ensures scar-free tissue repair, as elevated amounts of HA are generated during embryonic tissue repair. The synthetic machinery for dermal HA is provided by dermal fibroblasts, which is why pharmacologic approaches to improve skin hydration should focus on them. Regrettably, exogenous HA is quickly broken down and removed from the dermis.

Skin hyaluronic acid synthases

TGF-β1 differently upregulates the expression of HAS-1 and HAS-2 genes in the skin's dermis and epidermis, suggesting that the functions of HA in the dermis and epidermis are distinct and that HAS isoforms are independently controlled. Keratinocyte growth factor has the ability to increase the mRNA expression of HAS-2 and HAS-3. This, in turn, can activate keratinocyte migration and drive wound healing, resulting in the accumulation of intermediate-sized HA within keratinocytes and in the culture medium. The enhanced synthesis of HA stimulates the migratory response of keratinocytes during wound healing. In addition, fibroblasts' IL-1β and TNFα as well as rat epidermal keratinocytes' epidermal growth factor stimulate HAS-2 mRNA.

There have been reports of dysregulated HA synthase expression during tissue damage. After a skin injury in mice, there is a large rise in HAS-2 and HAS-3 mRNA, which results in enhanced epidermal HA. The rare autosomal recessive illness juvenile hyaline fibromatosis is characterized by the deposition of hyaline material and many skin lesions. The lower synthesis of HA in skin lesions is explained by a considerable decrease in the expression of HAS-1 and HAS-3. Glucocorticoids virtually entirely suppress HAS mRNA in dermal fibroblasts, where HAS-2 is the main isoform. This finding suggests a mechanistic foundation for the decreased HA in atrophic skin that results from local glucocorticoid treatment.

skin's hyaluronidases

Which of the several HYAL in the skin regulates the HA turnover in the dermis and epidermis is still unknown. By understanding the biology of HYAL in the skin, new pharmaceutical targets to address the age-related turnover of HA in the skin may become available.

The skin's HA receptors

Together with CD44, HA is co-localized in the dermis and epidermis. The precise CD44 variations found in the various skin compartments, however, remain unclear. It has been observed that CD44-HA interactions promote the binding of Langerhans cells to HA in the keratinocyte matrix through their CD44-rich surfaces as the keratinocytes migrate through the epidermis. The human skin expresses RHAMM as well. RHAMM mediates the TGF-β1-induced stimulation of fibroblast motility, and fibroblasts can undergo fibroblast transformation if RHAMM is overexpressed.

Ageing skin and hyaluronic acid

While HA is still present in the dermis, the most notable histochemical alteration seen in senescent skin is the remarkable loss of epidermal HA. It is uncertain why HA homeostasis changes as people age. As was previously mentioned, the underlying dermis affects the production of epidermal HA, which is regulated differently from dermal HA synthesis. It has also been documented that aging causes the HA polymers in skin to gradually shrink in size. Skin moisture is lost as a result of the epidermis losing the primary molecule that binds and holds water molecules. The primary age-related alteration in the dermis is the growing avidity of HA with tissue structures and the corresponding decrease in HA extractability. This is similar to the gradual reduction of collagen extractability with age and the progressive cross-linking of collagen. The apparent atrophy, suppleness loss, and dehydration that accompany aging skin are caused by all of the aforementioned age-related processes.

Repeated and prolonged exposure to UV light causes premature aging of the skin. About 80% of the aging of facial skin is caused by UV radiation. Damage from UV light initially results in a modest type of wound healing and is first linked to an increase in dermal HA. In naked mice, as little as 5 minutes of UV exposure resulted in increased HA deposition, suggesting that UV radiation-induced skin damage happens very quickly. The skin's initial redness after being exposed to UV radiation could be the result of a modest edematous reaction brought on by increased histamine release and HA deposition. Ultimately, prolonged and repeated UV exposures mimic the normal wound healing response by depositing scar-like type I collagen instead of the normal combination of types I and III collagen that provides pliability and resilience to the skin.

Photoaging of the skin leads to abnormal GAG distribution and content compared to scars, or the wound healing response, with decreased HA and increased levels of chondroitin sulfate proteoglycans. Collagen fragments activated αvβ3-integrins were found to be responsible for this reduction in HA synthesis in dermal fibroblasts, which in turn inhibited Rho kinase signaling and nuclear translocation of phosphoERK, lowering HAS-2 expression. Some of the molecular alterations that may differentiate photoaging from natural aging have recently come to light. By utilizing human skin tissue specimens from the same patient that were both photoexposed and photoprotected, we have demonstrated a notable rise in the expression of HA with a smaller molecular mass in the photoexposed skin when compared to the photoprotected skin. A notable decrease in HAS-1 expression and an increase in HYAL-1, -2, and -3 expression were linked to this rise in degraded HA. In addition, HA receptor expression on CD44 and RHAMM was considerably lower in photoexposed skin than in photoprotected skin. These results suggest that a unique HA homeostasis characterizes photoexposed skin, and hence extrinsic skin aging. Additionally, we examined photoprotected skin tissue specimens from both adult and pediatric patients, and found that intrinsic skin aging was linked to a significant decrease in HA content as well as downregulation of CD44, RHAMM, HAS-1, and HAS -2. Comparable outcomes for photoprotected skin have also been documented for HA, HAS-2, and CD44 in both sexes.

In summary

According to the information that is now available, HA homeostasis shows a unique profile in intrinsic skin aging that differs greatly from that in extrinsic skin aging. Further knowledge is required to comprehend how HA interacts with other skin constituents and how it is metabolized in skin layers. This data will make it easier to control skin moisture in a sensible way, which could help improve the efficacy of existing medications and lead to the creation of new skin aging treatments.

[hayleymedbil]

The Ultimate Guide to Medical Billing Codes: Your Comprehensive List for Accurate Billing and Coding

**Title: The Ultimate Guide to Medical Billing‌ Codes: Your Comprehensive List for Accurate‌ Billing⁣ and Coding**

**Introduction:** In the complex world of medical billing and coding, one of the most ‍important aspects is using the correct medical ⁣codes. Medical codes ⁢are alphanumeric representations that healthcare providers use to ‍accurately describe medical procedures, diagnoses, and treatments for billing purposes. Understanding and correctly⁣ applying these codes is crucial to ensuring that healthcare providers receive ‍proper reimbursement for⁤ their services.

**Benefits of Using Medical Billing Codes:** – Ensures accurate and timely ​reimbursement from insurance companies – Helps ⁤prevent⁢ billing errors and potential audits – Improves communication among healthcare providers and insurance companies – ⁣Provides a standardized system for tracking patient care ‍and treatment

**The Most Common Medical Billing Codes:** Here is a comprehensive list of some of⁣ the most common medical billing codes used in the healthcare ​industry:

**1. CPT Codes (Current ‌Procedural Terminology)**

| Code |⁣ Description | | —-⁤ | ———– | | 99213 | Office or other outpatient visit for the evaluation and management of an established patient, typically 15 minutes | |‌ 99214 |⁣ Office or other outpatient visit for the evaluation and ‍management of an⁤ established patient, typically ‌25 ‌minutes | | 87880 | Strep A test, individual, with ⁣interpretation and report | | 93000 | Electrocardiogram, routine ECG with at ⁤least 12 leads; with interpretation and report |

**2. ICD-10 Codes (International Classification of Diseases, Tenth Revision)**

| Code ​| Description | | —- | ———– | | J45.901 | Unspecified asthma with (acute) ⁣exacerbation | | M25.511 | Pain in right shoulder | | S72.005 | Displaced fracture of ‌neck of right ‌femur |

**3. ⁤HCPCS Level II Codes ⁣(Healthcare⁤ Common Procedure Coding System)**

| Code | Description | | —- | ———– | | G0101 | Cervical or vaginal cancer screening; ⁤pelvic and clinical breast examination | |‍ J7321 | Hyaluronan or derivative, Gel-One, for intra-articular‌ injection, per dose | | Q2036 | Influenza virus ‍vaccine, quadrivalent, derived from cell cultures, subunit, ⁢preservative ​and antibiotic free, 0.5mL⁢ dosage, for intramuscular use |

**Practical Tips for ⁢Using Medical ‌Billing Codes:** – Stay updated on the latest ⁣coding guidelines and changes – Double-check each‍ code for accuracy ‍before ⁣submitting claims – Keep detailed documentation of all services provided – Utilize ‌coding software to streamline the process

**Conclusion:** Accurate medical coding is⁤ essential for healthcare providers ⁣to receive proper reimbursement for ‍their services. By understanding and using the​ correct‍ medical ‌billing codes,⁢ providers‍ can ensure smooth billing processes and​ avoid potential​ issues with‌ insurance companies. Stay informed on the latest coding updates,⁣ double-check your ‌codes, and maintain detailed documentation to optimize your billing practices. Remember, accuracy is key when it comes to medical coding!

By following this ultimate guide to‍ medical billing codes, you ‌will be better equipped to navigate the complex world of healthcare billing and ensure that⁢ you are accurately documenting and coding all patient encounters. Remember, the success⁣ of your practice depends on accurate and compliant medical coding practices.

https://medicalcodingandbillingclasses.net/the-ultimate-guide-to-medical-billing-codes-your-comprehensive-list-for-accurate-billing-and-coding/

[healthysupplementwithjessica]

As we age, vital components like hyaluronan diminish, causing joint stiffness and discomfort.

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This groundbreaking formula includes Mobilee®, a patented ingredient that multiplies hyaluronan in synovial fluid by up to 10 times.

By improving joint lubrication and reducing friction, Joint Genesis enhances mobility and alleviates discomfort.

It is the only supplement that combines four research-backed nutrients with Mobilee® for comprehensive joint support.

[kenyasurrogacy]

PICSI Treatment in Kenya

As fertility treatments continue to evolve, many couples in Kenya are finding new hope in advanced reproductive technologies. One such breakthrough is PICSI (Physiological Intracytoplasmic Sperm Injection), a refined method that improves the chances of successful fertilization and pregnancy. In Kenya, PICSI has become a popular choice for couples seeking effective solutions to infertility, especially for those facing male fertility challenges.

What is PICSI?

PICSI is an advanced version of the ICSI (Intracytoplasmic Sperm Injection) procedure, used to select the healthiest and most viable sperm for fertilization. The process involves a unique technique where sperm are tested for their ability to bind to hyaluronan, a natural compound that surrounds the egg. This binding is an indicator of sperm maturity and health. By using this technique, PICSI selects only the highest-quality sperm, which can improve embryo development and increase the chances of a successful pregnancy.

Why Choose PICSI Treatment?

PICSI treatment can offer significant advantages for couples dealing with specific infertility challenges, such as:

Male Factor Infertility: For men with low sperm motility, abnormal sperm shape, or DNA fragmentation, PICSI can improve the likelihood of fertilization.

Improved Embryo Quality: Selecting high-quality sperm may lead to healthier embryos, which are more likely to result in successful implantation and pregnancy.

Lower Risk of Miscarriage: By choosing mature and healthy sperm, PICSI may help reduce the risk of chromosomal abnormalities, which is a common cause of miscarriage.

Enhanced IVF Success Rates: Studies have shown that PICSI can improve overall success rates for couples undergoing IVF, making it an ideal option for those seeking a reliable solution.

The PICSI Process

The PICSI procedure is carried out as part of an IVF cycle, specifically during the fertilization phase:

Sperm Collection: A sperm sample is collected from the male partner or donor.

Sperm Selection: The sample is tested with a hyaluronan-coated dish. Sperm that bind to the hyaluronan are selected, as this indicates their maturity and readiness for fertilization.

ICSI Injection: The selected sperm are then injected directly into the egg, allowing fertilization to occur.

Embryo Transfer: After successful fertilization, the healthiest embryos are transferred to the uterus for implantation, with the aim of achieving a pregnancy.

PICSI in Kenya: A Path to Parenthood

Kenya has become a trusted destination for fertility treatment, with world-class clinics offering advanced reproductive technology, including PICSI. Patients can expect compassionate and professional care, with specialists who are experienced in customizing treatment plans to meet each couple’s unique needs.

For couples facing fertility challenges, the PICSI procedure can be a life-changing solution. Kenya offers affordable, high-quality fertility treatments with a focus on delivering safe and effective results. By choosing PICSI, couples are taking a positive step toward realizing their dream of starting or growing a family.

Contact Us

If you’re interested in PICSI treatment in Kenya or would like to explore other fertility solutions, our team at Kenya Surrogacy is here to help. We offer guidance, support, and expert care tailored to your needs.

Email: us-info@kenyasurrogacy.com Contact: +254 100 241 479