#human gene editing

[wire-bunch]

i think there should be more robots that arent good at programming and dont know a lot about related subjects honestly. i mean humans dont have an in depth understanding of biology and anatomy just because theyre human, sure they know what kind of stuff is supposed to be inside of them but not very specific biological processes, names of proteins and all that stuff - so why should a robot know what each little part of it does? if its purpose isnt to be a self-repairing mechanic, whats the point of knowing where all the individual little wires connect to and what each of them is responsible for? let robots be a bit dumber is what im saying

[dandelionsresilience]

Good News - July 8-14

Like these weekly compilations? Tip me at $Kaybarr1735! And if you tip me and give me a way to contact you, at the end of the month I'll send you a link to all of the articles I found but didn't use each week!

1. Zoo welcomes birth of four endangered horse foals

“[The Marwell Zoo in GB] said it was "delighted" to welcome the arrivals to the endangered Przewalski’s horse herd. All four are female and said to be "doing well" after two were born in May and two in June. […] “These horses, that were previously listed extinct in the wild, are an example of how zoo breeding programmes can help restore threatened species around the world.” […] All the Przewalski’s horses alive today are descended from just 12 individuals. Current estimates suggest there are 178 mature individuals living in the wild.”

2. Restoring woodlands and planting trees for sustainability success

“In 2023, [the Marwell Zoo] planted 9,000 new trees […] both within the zoo and on our surrounding land. […] Marwell tries to encourage natural feeding behaviour and nutrition by including leafy material [in animals’ feed] as much as possible. […] Planting more trees and enhancing management of our existing woodlands, prepares the way to further self-sufficiency in browse production in the future. Plus, it creates new habitats for wildlife in our woodland areas.”

3. Inclusive Playgrounds Allow Children Of All Abilities To Play

“With ramps allowing children in wheelchairs to ascend the central play structure, as well as numerous other swings and apparatus usable for children of all abilities, the 16,000-square-foot P.K.’s Place is St. Paul’s first fully inclusive playground. […] To be universally accessible, a play area must have at least 70% of its play features fully accessible, far more than required by the Americans with Disabilities Act (ADA). […] Play areas should allow parents and grandparents with disabilities to participate as well.”

4. Combination treatment can increase human insulin-producing cells in vivo

“[Diabetes-model mice] were treated with the combination therapy [of a plant product called harmine and “a widely used class of type 2 diabetes therapy”] and their diabetes was rapidly reversed. Strikingly, human beta cell numbers increased by 700 percent over three months with this drug combination. "This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo. This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes," said Dr. Garcia-Ocaña, the paper's corresponding author.”

5. Decades of Dedication: Australia’s Largest Ongoing Urban Restoration Project

“[Friends of Lake Claremont] has transformed the area into a thriving ecosystem, re-establishing native habitats and fostering biodiversity. This year, 800 native seedlings (100 trees, 350 shrubs and 350 ground covers) have been planted on the northwestern buffer of Lake Claremont. Volunteers replaced a large Port Jackson fig (Ficus rubiginosa) affected by [beetle] infestation with native plants to enhance the local wildlife habitat, thereby benefiting insects, frogs, birds and brown bandicoots. […] Overall, the project contributes to the area’s function as a regional ecological corridor, linking inland bushlands, the Swan River and the Indian Ocean.”

6. Important habitat for fish in Heart of the Fraser now conserved

“British Columbia’s iconic salmon now have more protected spawning habitat in the lower Fraser River, thanks to the Nature Conservancy of Canada’s (NCC’s) conservation acquisition of Carey Island. […] Carey Island and its gravel channels offer calm and crucial spawning and rearing habitat for the river’s fish and aquatic species. […] The Pelólxw Tribe […is also] actively working to restore the resilience of aquatic habitat within this stretch of the Lower Fraser. NCC is exploring opportunities to collaborate with the Pelólxw Tribe in support of their vision for stewardship of the area, which prioritizes both ecological and cultural values.”

7. Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

“[R]esearchers have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. With further development, it could pave the way for treatments that are administered only once and have fewer side effects. The new method precisely and durably corrects the mutation in human lung cells, restoring cell function to levels similar to that of Trikafta [the standard treatment since 2019].”

8. Montana’s High Court Considers a Constitutional Right to a Stable Climate

“At issue was the appeal of a decision last year, when a Montana judge blocked a state law that prohibited agencies from considering climate impacts when deciding whether to approve fossil fuel projects such as new power plants, pipelines or mining. The ruling, by District Judge Kathy Seeley, was prompted by a lawsuit filed by 16 youths who argued that the law violated Montana’s constitutional right to a “clean and healthful environment.” It was the first ruling in the United States to effectively establish constitutional rights to a stable climate[��.]”

9. The US is about to get its first solar-covered canal

“The first canal-based solar project in the U.S. is nearing completion on tribal lands south of Phoenix, Arizona. […] The long, narrow solar array design would snake along the line of the canal and tap into the local electrical distribution grid every 1,000 feet, or every one megawatt. […] “Canal solar allows for greater power production per land size, cleaner water, less power transmission losses, and significant reduction in evaporation[….]” Covering the entire 8,000 miles of canals and waterways managed by the Bureau of Reclamation with solar panels could generate over 25 gigawatts of renewable energy and reduce water evaporation by tens of billions of gallons[….]”

10. Camera traps offer glimpse of first beaver born in Northumberland for 400 years

“"It’s such a relief that they have bred successfully and to see a new fluffy kit swimming with the family[….]” In just one year [since releasing the beavers], there has been a noticeable increase in resident trout, says the National Trust, along with more regular visits from kingfishers and grey herons. There are more insects at the site, too, thanks to the organic matter that builds up behind the dams, which in turn provides food for Daubenton’s bats. […] Beavers also play an important role in creating habitats that are more resilient to the effects of climate change[….]”

July 1-7 news here | (all credit for images and written material can be found at the source linked; I don’t claim credit for anything but curating.)

[ashybaby]

original @asntde

[neurotonic]

official ieytd twitter acc liked some of my ieytd doodles i posted there

Remembers my literal display name is #1 john juniper hater on there

[vhstown]

cannot wait to learn about nucleic acids and genetics and finish my fat ass book about mitochondria so i can girlsplain about biology and disguise i5 as a spiderverse fanfic

[always-a-slut-4-ghouls]

I’m going to post a link and stop infodumping in the comments:

While you could be like “I’m only referring to individual events and not large scale genetic exchanges” the fact that so many half elves have been born and then reproduced with other species (say, humans and elves) means that not only can they hybridize and create fertile offspring despite being two distinct species, a thing that can happen, for example with wolves and coyotes, like with wolves and coyotes there are probably populations of both species with a lot of cross genes just integrated into them

Nobody:

Me: So since half elves are fertile in most media that includes them are elves just humans with pointy ears because since they can reproduce successfully with humans to create fertile offspring that implies that they’re just subspecies or a breed of human or something and could half elves become a new breed of human like a labradoodle because it seems to me that-

The sniper: *takes the shot*

[loxodontadae]

i cannot rationalize this, nor should i fight it

but i have the urge to draw a locust drone (gears of war) resident-evil-fied fucking leon kennedy

[tenth-sentence]

Show me a ewe whose genes have been altered so that it secretes a human protein in its milk, and it is much less clear which part is human, which is sheep.

"Frankenstein's Footsteps: Science, Genetics and Popular Culture" - Jon Turney

[roboticchibitan]

Today I'm going to talk about a form of radical resistance that anyone, no matter their situation, can engage in: cultivating hope.

Are you filled with hopelessness and despair at the state of the world? I have some good news and some bad news.

The bad news is you've fallen for a tool of the status quo. Despair freezes us. It keeps us from imagining and working towards a better world. Despair is easy, because it means we have no reason to take action to make things better. Capitalism? Our oppressors? They want you hopeless for a reason. Because you're easier to control that way.

The good news is! There's a lot of very real reasons for hope. However, hope is something you have to cultivate. It takes work. It is a radical act. It is looking at the status quo and going "actually, no. I refuse."

Maybe you can't risk losing your job to unionize your workplace. Or maybe you're an oppressed minority who can't risk going to protests because our criminal justice system is racist. But cultivating hope in yourself is just as radical an act of resistance as those two things. It is another form of imagining and working towards a better world.

It's not as flashy as starting a union or going to a protest, true. Maybe it feels selfish, like you're only helping yourself. But that's not true. It's a lot harder to help others when you, yourself, are frozen by despair. By working on yourself, you are making it easier for you to help others, in whatever form that takes for you.

For me, since I started my hopepunk practice I have been more able to engage in activism, even if I no longer post about it. Before calls to action froze me. I was so overwhelmed by the sheer magnitude of our problems that I was unable to address any of them.

Since I've started cultivating hope in myself, I've unfrozen enough that I was able to choose the causes that matter to me and put my energy there. I engage in more charitable donations and political actions now than I did before. I am happier and also helping others more than I did before.

Cultivating hope in yourself is hard at first. You feel defeated before you even start. But you start putting work in and you find a little hope. And then a little more. And a little more. And then, suddenly. It snowballs and you're doing better than you have in years, and hope comes easier to you now.

If you don't know where to start, go follow @hopepunk-humanity @hope-for-the-planet @afeelgoodblog and @reasonsforhope or follow the hopepunk tag

There's also things like the good news network, who have a daily email they send out with a handful of positive news stories. Some of them I find kinda dumb and shallow like "lost dog returned after 3 years" type stories. But there's also a lot about scientific advancments in green energy, medical care, etc that I find helpful for cultivating hope. Did you know about the CRISPR gene editing tool that's being used to cure incurable illnesses? I didn't! And now I do! afeelgoodblog also runs a substack "best news of last week" newsletter every Monday that I find has stories with more substance, tho it is US focused.

Despair isn't helping anyone, especially not you. Engage in a radical act and start cultivating hope in yourself. You deserve to leave that despair behind, and in the process, you are directly going against the powers that have decided we are easier to control if we are miserable.

[dumpster-fire-on-wheels-w-possum]

Gene Editing Shenanigans

So I completely missed the deadline for Adventure Jam 2023 but here is the premise of a narrative cyber-noir point-and-click adventure game (lemme put all of that into tags lol).

A classic story of an affair - an unhappy wife cheats on her busy husband with an affair partner who gets her pregnant sometime in the 2050s.

The victim cuts off the affair partner (our criminal) and successfully plays off the child as the offspring of her husband. Given the husband's work, the child becomes one of the first kids to be commercially genetically engineered to be one of the picture-perfect advertisements for the newest launch at Gen.

The affair partner learns this years later and is horrified that his offspring is the very thing he stands against. After unsuccessful attempts at "getting his justice," he poisons the mother of his child in hopes of getting custody, and you, the detective just arrive at the scene...

[figgup-updates]

The Top 10 Scientific Discoveries In Last Decade That Changed The World

From new planets to groundbreaking medical advancements, these discoveries have changed the way we see the world around us. So, without further ado, let’s dive into the first discovery. The Top 10 Scientific Discoveries In Last Decade That Changed The World 10. New Species Discovered The discovery of new species is always exciting, and the last decade was no exception. Scientists are…

[deva-arts]

reblooping because I've got Sophie on the mind again

Ah yes

Parenthood that would never happen, set in a far, distant, un-drawn and unexplored future, with a small baby to match. The lil baby, Sophia Herrera-Wilson, or just Sophie

Thankfully, "Baby Einstein's Compendium for Enhancing Neonatal Potential" Is a picture book! By which I mean it is full of graphs and plotted statistical data with pretty pastel colors. The only thing it enhances is headaches.

[clemencie]

npr

listen here

[bogleech]

You should be glad animals exist that can inconvenience or hurt you, including any you have a terrible phobia or horrible experience with. It means us humans have not yet fully subjugated nature. It is a terrible experience to have a house infested with fleas or to get mauled by a bear but the only scenario in which living organisms can never ruin your life is a scenario in which we've sterilized even more of the environment, or replaced all living things with gene-edited custom ones to our liking as some people *actual now advocate for.* :(

[extremely-nervess]

So, what’s the story with Fae? Why is her (?) face turning into rock?

Faelyn is a her indeed, and its not rock, its actually keratin, and its the result of a gene editing retrovirus she contracted resucing someone from a (morally ambiguous) lab. Its not just her face, honestly her face is doing better than most of her.

Never sure how much context to give haha so if you just wanted the short version stop reading here... Said virus (plural actually) was designed with the intention of force evolving genetically similar species into a presumed extinct alien, and its not really something that should affect humans. Fae managed to contract it when wounded likely because she is the daughter of a heavily gene-modded pop star, and her genetic code is designed to be easily modified and extended, and is full of dormant 'designer' viral strains which have interacted with these newcomers. As a result, Fae is very sick. The Keratin growths precede withering of the affected areas, and at this point she's more or less lost the use of her extremities. She's an emotionally robust person, and modern (Far far future from our perspective) medicine, and robotic assistive technology has helped keep her active thus far, but its not looking good. Alecto has had to handle some missions solo, and while Fae has pushed herself to join in one some that she felt were important she's really on her last legs both physically and emotionally.

[dandelionsresilience]

Good News - July 15-21

Like these weekly compilations? Tip me at $kaybarr1735! (Or check out my new(ly repurposed) Patreon!)

1. Thai tiger numbers swell as prey populations stabilize in western forests

“The tiger population density in a series of protected areas in western Thailand has more than doubled over the past two decades, according to new survey data. […] The most recent year of surveys, which concluded in November 2023, photographed 94 individual tigers, up from 75 individuals in the previous year, and from fewer than 40 in 2007. […] A total of 291 individual tigers older than 1 year were recorded, as well as 67 cubs younger than 1 year.”

2. Work starts to rewild former cattle farm

“Ecologists have started work to turn a former livestock farm into a nature reserve [… which] will become a "mosaic of habitats" for insects, birds and mammals. [… R]ewilding farmland could benefit food security locally by encouraging pollinators, improving soil health and soaking up flood water. [… “N]ature restoration doesn't preclude food production. We want to address [food security] by using nature-based solutions."”

3. Harnessing ‘invisible forests in plain view’ to reforest the world

“[… T]he degraded land contained numerous such stumps with intact root systems capable of regenerating themselves, plus millions of tree seeds hidden in the soil, which farmers could simply encourage to grow and reforest the landscape[….] Today, the technique of letting trees resprout and protecting their growth from livestock and wildlife [… has] massive potential to help tackle biodiversity loss and food insecurity through resilient agroforestry systems. [… The UN’s] reported solution includes investing in land restoration, “nature-positive” food production, and rewilding, which could return between $7 and $30 for every dollar spent.”

4. California bars school districts from outing LGBTQ+ kids to their parents

“Gov. Gavin Newsom signed the SAFETY Act today – a bill that prohibits the forced outing of transgender and gay students, making California the first state to explicitly prohibit school districts from doing so. […] Matt Adams, a head of department at a West London state school, told PinkNews at the time: “Teachers and schools do not have all the information about every child’s home environment and instead of supporting a pupil to be themselves in school, we could be putting them at risk of harm.””

5. 85% of new electricity built in 2023 came from renewables

“Electricity supplied by renewables, like hydropower, solar, and wind, has increased gradually over the past few decades — but rapidly in recent years. [… C]lean energy now makes up around 43 percent of global electricity capacity. In terms of generation — the actual power produced by energy sources — renewables were responsible for 30 percent of electricity production last year. […] Along with the rise of renewable sources has come a slowdown in construction of non-renewable power plants as well as a move to decommission more fossil fuel facilities.”

6. Deadly cobra bites to "drastically reduce" as scientists discover new antivenom

“After successful human trials, the snake venom antidote could be rolled out relatively quickly to become a "cheap, safe and effective drug for treating cobra bites" and saving lives around the globe, say scientists. Scientists have found that a commonly used blood thinner known as heparin can be repurposed as an inexpensive antidote for cobra venom. […] Using CRISPR gene-editing technology […] they successfully repurposed heparin, proving that the common blood thinner can stop the necrosis caused by cobra bites.”

7. FruitFlow: a new citizen science initiative unlocks orchard secrets

“"FruitWatch" has significantly refined phenological models by integrating extensive citizen-sourced data, which spans a wider geographical area than traditional methods. These enhanced models offer growers precise, location-specific predictions, essential for optimizing agricultural planning and interventions. […] By improving the accuracy of phenological models, farmers can better align their operations with natural biological cycles, enhancing both yield and quality.”

8. July 4th Means Freedom for Humpback Whale Near Valdez, Alaska

“The NOAA Fisheries Alaska Marine Mammal Stranding Hotline received numerous reports late afternoon on July 3. A young humpback whale was entangled in the middle of the Port of Valdez[….] “The success of this mission was due to the support of the community, as they were the foundation of the effort,” said Moran. [… Members of the community] were able to fill the critical role of acting as first responders to a marine mammal emergency. “Calling in these reports is extremely valuable as it allows us to respond when safe and appropriate, and also helps us gain information on various threats affecting the animals,” said Lyman.”

9. Elephants Receive First of Its Kind Vaccine

“Elephant endotheliotropic herpesvirus is the leading cause of death for Asian elephants (Elephas maximus) born in facilities in North America and also causes calf deaths in the wild in Asia. A 40-year-old female received the new mRNA vaccine, which is expected to help the animal boost immunity[….]”

10. Conservation partners and Indigenous communities working together to restore forests in Guatemala

“The K’iche have successfully managed their natural resources for centuries using their traditional governing body and ancestral knowledge. As a result, Totonicapán is home to Guatemala’s largest remaining stand of conifer forest. […] EcoLogic has spearheaded a large-scale forest restoration project at Totonicapán, where 13 greenhouses now hold about 16,000 plants apiece, including native cypresses, pines, firs, and alders. […] The process begins each November when community members gather seeds. These seeds then go into planters that include upcycled coconut fibers and mycorrhizal fungi, which help kickstart fertilization. When the plantings reach about 12 inches, they’re ready for distribution.”

July 8-14 news here | (all credit for images and written material can be found at the source linked; I don’t claim credit for anything but curating.)