#hope this was interesting :]

[arthurs-vaccine]

Hi! Could you elaborate on why you think Arthur wasn't in much pain in the moments leading up to his death?

Sure, I love an excuse to talk about the medical perspective of that last mission.

We call it the end of life pain relief. So when a person is dying, the body's ability to process pain can change due to all kinds of different physiological and psychological factors.

Lots of things influence this, including the body’s natural shutdown mechanisms, changes in brain function, and the effects of illness or trauma.

When you're nearing death, especially after chronic illness and injury (in this case, Arthur's TB and the fight with Micah), the brain's ability to perceive and process pain can diminish. This is because the body starts to slow down as part of the dying process, leading to less responsiveness to external stimuli, including pain.

As shock sets in due to blood loss or severe trauma, the body redirects blood flow away from the extremities and focuses on vital organs. This can cause a numbing effect on the body, making pain less perceptible too.

So the odds are that while Arthur probably was in pain, it was likely significantly reduced as he got closer to his final moments.

[tumblingxelian]

so first, fair explanations - my devices are WEIRD. For some godforsaken reason, they are EXTREMELY TEMPERAMENTAL. Sometimes they delete asks I send (sometimes Tumblr does this, but it happens to me SO MUCH. I've sent you asks that never showed, that I've had to resend, I'm sure, so if you ever get doubles, that’s why). Sometimes I don’t get alerts. Sometimes I get the same alert six times in a row. Sometimes they just decide to crop my home page or queue, and I have to refresh the page four times before it fixes it. It’s why I keep including @'s, or might look like I didn’t see something - sometimes, I didn’t. Sorry if that’s annoying, but I genuinely think I might be cursed at this point, it’s happened on MULTIPLE DEVICES, THIS IS THE SIXTH TABLET ITS HAPPENED ON, TECH GODS!? DID I ANGER YOU SOMEHOW!?

(*and breathe*)

Moving on (sorry about that!) you once mentioned your Six-Teen Heroes AU, and I've seen a few things on @princess-of-the-corner, but what is it exactly? It sounds interesting! If you don’t have a lot of time, is there a link you can send me?

Hope your day is going good (and that your tech is cooperating with you!)!

oof, that sounds rough @rachelsshowerthoughts my sympathies!

I think this is the first ask I've ever received from you ><

I'll try to tag more often and such going forward!

Now, as to your question!

Six-Teen Heroes AU is one of my more well developed AU ideas, up there with the Alternative Butterfly and Lady Glasswing stuff.

The basic gist is that this AU opens with Fu fighting off an assault from Gabriel as the Scarlet Sovereign. A crimson themed villain in possession of the Ladybug Miraculous.

He may be supported by Nathalie wielding the revised Peacock. Or she just has a gun and or is waiting in the car.

Hawk Moth reveals he's been experimenting with the magic before coming and unveils his Charm Construct. Basically a mundane object analyzed by the charm and made into the 'core' of a magical construct to fight for him.

The battle turns against Fu & he is forced in his bid to escape, to release many of his Miraculous. Both to cover his retreat but also to seek out allies to help him.

Slipping away with Wayzz and an incredibly pissed off but still trapped in the box Plagg, Fu vanishes.

Gabriel doesn't know if those released were the one's he's after though or where Fu went so he's stuck with the less subtle option of taking the city hostage to force Fu out of hiding.

But not before he goes to deal with the big ass wound Fu gave him. Turns out shields can cut you up really badly if they spin and are thrown hard enough.

Anyway,

The seven Miraculous released largely split up to go find holders they identify with. They also have a vague discussion regarding how best to avoid a fate like Tikki's and how to best interprit Fu's instructions to fit their goals.

IE, they preference younger wielders so if one sucks the others can help free them, they will keep things close to their chests & their goal is free Tikki, not helping restart the order or making ideal heroes strictly speaking so their chosen need to be effective not necessarily nice.

They largely pick well though.

Also as an aside a big theme is how all of them wear masks and how being a hero and having a new mask influences them & their various ideas of identity.

Sass, the elder Kwami of time & Eternity, or the Ouroboros Snake as they introduce themself picks Luka. Drawn to his empathic abilities and calm mind as well as protective nature. They have a good rapport.

Luka's mask is essentially just playing his base personality to the hilt while obscuring all the massive issues he has. IE, "I've seen my sister die, my friends die, I've seen us lose... But I am OK!"

Roaar stuck with Sass.

She was very drawn to Juleka's scream thrash metal voice & the fact rather than be afraid she was excited to have a monstrous tiger in her room. Right up until Roaar became small & cute & they had to have a conversation, still, the Kwami of Ignition & Chaos thinks this can work.

Juleka has not confessed to Rose yet, in fact she still struggles to speak with most people at all. As Roaar though, she can lose herself in her new identity, she is a berserker, a bubbling mass of explosions and confidence and Rose will surely love this version of her more right?

Rose is a lil freaked out by Violet Tigress, but also kind of into her.

Not all pick their targets on the first night nowever & its only later that Gabriel makes his move anyway, but:

Kaalki picks Nino, impressed by his various ambitions and wide range of skills, as well as the fact he heroically got other people out of dangers first before thinking of himself & only panicking after the fact.

She is less impressed with his relaxed attitude and sense of style but they can work on that. They butt heads a lot and Nino is... Not strictly above using Voyage (Which has various powers here, individual teleportation multiple times, portals, ETC) for personal gain. Leading to a bit of "What am I in the dark?" worrying.

Tirxx chooses Lila, having arrived early, finding her poker face and frantically creative mind, as well as penchant for trouble making charming. But also low key wanting to mentor her on how to get what she wants with zero lies, just creative use of the truth.

Lila is very much into the idea of being a hero & feels the only thing about a person that matters is how they are perceived. IE, there is nothing deeper or more real than the mask one is wearing.

She & Nino have a strong focus on helping civilians in this AU, as there's no Ladybug to fix everything.

Meanwhile, Kagami has only just arrived in France.

Her family's new home is not ready yet so she's staying at the Le Grand Paris Hotel at Andre's insistence. He hopes to sort out whatever 'tiff' is happening between Tomoe & Agreste brands. & assigns Chloe as Kagami's hostess, a task she takes to with great enthusiasm. Give Chloe an important task and she will do it.

The pair actually get on quite well, in part cos of their distinct but similar experiences with Autism (Neither are diagnosed but they both practice smiles, ETC)

Anyway, Longg likes Kagami's general dutiful vibe, respectful but bold manner and bravery, as well as skill with a sword and chooses her.

Kagami regards her time as Ryuko as noble work, much more what she was born for than what she usually does. & sees the mask as a way to let off steam so she can keep her real impassive mask up.

Meanwhile Pollen is impressed with Chloe's sheer force of personality & will, She might be shocked or irritated by things but she is largely unflappable beneath the veneer & has much potential.

To Chloe, the hostess, and heiress to Style Queen & Andre, & Queen Bee are all entirely distinct identities. IE, she doesn't consider it inconsistent to do corrupt things to win an election as Chloe, but would consider them wrong as Queen Bee. But these things have a way of bleeding into one another.

These are the Six-Teen Heroes, but where's the seventh?

Well, Mullo divided herself up to look for an ideal candidate and found several, so she took awhile to make up her mind. Followed by actually having trouble making contact because of her chosen's incredibly bad luck! Suffice to say, Mullo chose Marinette.

Note:

Also Tomoe is the Butterfly Wielder, she has no interest in the power that surpasses death as Gabriel does. She's after al; the Miraculous & wants to Akumatize the wielders. She's seeking more general "Power" but is also much more reasonable & so can be worked with at times.

She & Gabriel are essentially fighting over the Miraculous stuff & who gets them, likely having only met & become allies because of their mutual search. She is also a great way to have a hero "go evil" without permanent issues.

Fu is out of the picture for awhile as Kaalki opened a portal for him and he ended up very, very far away.

Also as noted, all the Heroes have more varied power sets.

The Bee for example is less just "Stun enemy" and more about imposing a command or creating order. So she can sting someone and "Impose!" a command, or perhaps sting rubble and order it back into a wall.

People can also use smaller variants of their powers several times or big one's once.

Oh, also the Snake has a vague but actually limited number of uses & each use leaves everyone with a sense of deja-vu. So the more uses the less helpful it is.

Finally, all the heroes have very different relationships behind the masks to in the masks, that create contrasts. Like Luka generally trusts Lila and thinks she's very cool, he 100% does not trust Volpina cos he's seen her make some less than stellar decisions.

Chloe & Kagami 'get' each other surprisingly well, even if Kagami doesn't like what Chloe does she understands the logic perfectly well. But as Ryuko and Queen Bee often butt heads about how to approach things.

Nino & Juleka would normally get along fine if a bit awkwardly, but as heroes, she doesn't want to listen to what he has to say and he can't stand how reckless and wild she is.

Oh Adrien's also attending school, but is legit just a nice civilian boy at the moment XD Maybe a Peacock later?

[repurposedmeatlocker]

FMK: Judas, Amanda Palmer, L from Death Note

HELP??? THIS SELECTION OF INDIVIDUALS???

I am gonna assume by Judas you mean Judas from The Bible 😭 if I am wrong, well...honest try.

Fuck: Judas

Marry: L

Kill: Amanda Palmer (idk anything about her btw I just have no strong feelings so ends up on the chopping block, unfortunately.)

[bixels]

As gen-AI becomes more normalized (Chappell Roan encouraging it, grifters on the rise, young artists using it), I wanna express how I will never turn to it because it fundamentally bores me to my core. There is no reason for me to want to use gen-AI because I will never want to give up my autonomy in creating art. I never want to become reliant on an inhuman object for expression, least of all if that object is created and controlled by tech companies. I draw not because I want a drawing but because I love the process of drawing. So even in a future where everyone’s accepted it, I’m never gonna sway on this.

[poorly-drawn-mdzs]

I love you Safety Wizard.

(Inspired by @keroascrazy)

[ritualvirtuality]

please do look it up if you dont know the date bc there may be at least an approximate answer and otherwise the last option will completely dominate and this poll will be boring.

and dont be like 'but i cant sing'... just answer the earliest tune you know well enough that you COULD sing it

periods of western classical music provided only for reference

[thebeloathed]

I love flirty Stan that becomes a flustered mess the second it's reciprocated

[tizzymcwizzy]

this is a poster i made for my call to action assignment in humanities! it's a bunch of basic and easy stretches for people who sit and work at a desk all day (me)

the idea is that you'd put the poster up above ur desk and do the stretches every 30 minutes or so,, the whole routine won't take more than about 6 minutes to complete and when done regularly it can prevent wrist, shoulder, neck and back pain! :)

all these stretches can be done while sitting (although i HIGHLY recommend you stand up and move around while taking a break from working)

you can get a free digital copy of this poster here on my gumroad!

and you can order a print/poster here from my inprnt!

[chloesimaginationthings]

Can you imagine if the Aftons were in FNAF into the pit

[blabberoo]

prev | next

[artistotel]

hey! for todays protest, i made this little zine about palestine (holding just simple and basic information).

you can download the zine here, fold it yourself, and distribute it around.

no credit is needed. feel free to leave it around bars, protests, or wherever. simply print it (borderless) and fold it. here is a tutorial on how to do it.

dont stay silent. there is a genocide of horrendous, atrocious proportions going on. also if you are a zionist here to argue with me, i dont plan to entertain you at all, not on my art blog. fuck off, you'll be swiftly blocked. i see enough of you clowns on my main and i have no energy for you. you can skip the death threats too bc i dont give a shit.

(i'm off to get ready for a surgery now, i just wanted to post it before this. if you need anything, i might take a bit to reply)

[buglaur]

[aueua]

people with siblings: how do you feel about them?

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[lupucs]

Undyne tries to be a good lab partner to Alphys but then Frisk shows up with some newfound skills 🐟🦖 Made with Blender!

| Music: [Track 1] [Track 2] | Watch on Youtube |

[ochiody]

preparations

based off this post by @letsplaythermalnuclearwar :)