#glp

[rainedragon]

Imai Kira for the Gothic Lolita & Punk Brand Book November 2007

[ablackbrick]

War Song

“The equanimity of a male jackalope does not necessarily translate into non-aggression or passiveness. It just means he has a well-grounded equilibrium and a broad-minded perspective when he engages in confrontations. In fact, his balanced steadfastness in the midst of conflict can be very intimidating, even scary.�� Wm, Yost, from his interview in the alternative comics magazine Indy, issue #13,…

[aweightyissue]

On Weight Loss and Morality

Conversations around weight and weight loss have always been contentious.

The oft repeated mantra of weight loss has been “there is no silver bullet.”

It’s a jeering remark meant to chide dieters for trying anything beyond eating skinless chicken breast and 20 hours a week working out.

If you want to lose weight you have to pay the penance for every excess pound. You have to earn it.

Their smug satisfaction of watching weight loss aids fail is salt in the wound. They snickered at limitations and failure of Amphetamines, PhenFen, Ephedrine, Orlistat, LapBands, and Gastric Bypass.

See? You can’t cheat your way out. You did this to yourself, now you must suffer the consequences.

An anti weight loss movement emerged in opposition to this mentality. Body positivity is a healthy response to diet culture; making the radical assertion that existing in your body, the way it is, without trying to change, is not only okay, it’s a good thing.

Love your body and focus on being healthy. Your weight is not your worth. This cannot be said enough. Your worth in this world is not related to how your body looks.

When around came GLP-1 medications, the reactions have been fascinating.

The drugs themselves are remarkably effective, and instead of targeting the weight, they correct the underlying metabolic problem. They’ve been on the market for years and are generally known to be safe.

The ire toward them, is in some ways unsurprising.

No! You can’t do it the easy way! You have to work at it!

You’re stealing them from the deserving- the diabetics. Ironically, the same people they blame for their own illness.

The body positivity crowd response is fascinating as well. Taking the drugs is a betrayal. You shouldn’t want to change your body. You’re giving into diet culture. You shouldn’t want to fit conventional beauty standards.

The response has been negative from both sides. People feel entitled to police the bodies and choices you make about your body.

Both of these reactions are moral judgments. You have to pay for your sins. Either for gluttony or vanity.

The thing is, there should be no judgement at all.

Weight loss requires a lot of mental energy. You have to commit your mental and physical energy to it. There are a million reasons why someone can’t or doesn’t want to do that. And that’s okay. There is no reason why you should feel obligated to.

However, ignoring the very real disabling effects of obesity is also a kind of denial of humanity. It’s not anyone’s business, and to condemn someone for trying to prevent or correct the effects is kind of cruelty all its own.

There’s no reason someone should have to justify their desire to change their bodies or their efforts to do so.

Try to love your body, regardless of its size, but it’s okay if you want to lose weight and you don’t have to justify your reasons or your decision to use medication to do it.

Everyone else, support people if they choose to change their bodies as well as when they choose not to. It’s not your decision, your business or your place to judge them.

We, the body positivity advocates don’t criticize trans people for changing their bodies because they’re unhappy with the way it looks. We don’t shame people with disfiguring congenital defects who choose to have corrective surgery; even when it poses no health risk. We understand the very real effects of social stigma, and wouldn’t criticize them for avoiding it.

You’re punishing people trying to lose weight for the sins of vanity and envy.

The other assholes, you wouldn’t tell a cancer patient “there’s no silver bullet” or snicker when an experimental or risky treatment fails. You don’t tell people with high blood pressure or high cholesterol that taking medicine is “taking the easy way out.” You know it’s cruel, you simply want to punish people for the sins of gluttony and sloth.

All I’m saying is - leave the people taking weight loss meds alone.

Weight is not a moral issue.

Weight is not a moral issue.

Weight is not a moral issue.

Weight is not a moral issue.

Weight is not a moral issue.

[autistic-someone]

Ich glaube ich kann nie in meinem Leben normal sein wegen der Glpaddl stroyline in Tubeclash.

THEY'RE DOOMED! AND NOT REALLY GOOD FOR EACH OTHER! I LOVE THEM SO MUCH OMG!

[dr1nkm0r3bl00d]

❤️‍🩹🪓🧛🏻‍♀️🎸🤡🧨🩸🍿🌹🎪

[letmethinkaboutitalittlelonger]

This is unrelated to anything I ever posted, aber ich hör grade MATHEMATIC-RAPADDICT von Taddl und es gibt mir lowkey so viel.

Ich muss alle paar Wochen mal an die eine Folge von Minecraft Hero von ihm denken, wo er mit (ich glaube) glp darüber redet, dass es für ihn fine wäre wenn er mit 50 abkratzt wenn er sich davor ne schöne Zeit gegönnt hat. Und ich fand den take schon immer scheiße, aber dass es jz in der EP zu nem großen Teil um self-improvement und Leben appreciaten geht, gibt mir schon Hoffnung. So allgemein.

[ultimateshadow44]

A little fanart for germanletsplay ! I tried new things to expand, improve, and change my art style

(June 2023) ----------------------------------- Character: GermanLetsPlay ----------------------------------- Use without permission and credits not allowed -----------------------------------

If you like my content and want to watch developments, please follow me, like, and share my posts!

[iamcv04]

[punyamacademy]

Why is Good Laboratory Practices (GLP) Training Essential for Your Lab?

Good Laboratory Practices training ensures compliance with regulatory standards, enhances data accuracy, and improves lab safety. It builds credibility, reduces errors, and optimizes efficiency. Investing in GLP training fosters a culture of quality and ensures long-term success.

[jakewalkergif]

Ich gucke die letzten Tage die alten Minecraft Murder Folgen vom Freedom Squad und habe letzte Nacht gleich erstmal geträumt ich wäre GLP xD.

In dem Traum war ich Manu als Teenager und war mit meiner (seiner) Familie im Urlaub am Strand und Teenager Paluten war auch mitgekommen.

Viel weiß ich nicht mehr, aber ich lief auf jeden Fall mit Paluten um Strand herum, wir umarmten uns mehrfach und ich versuchte ihm als Manu etwas näher zu kommen, weil ich den übelsten Crush auf ihn hatte (witzig, habe ihn früher eigentlich nur mit anderen Leuten geshipped).

Noch irgendjemand, der häufiger träumt ein "Celebrity" oder fiktiver Charakter zu sein?

[rainedragon]

Victorian Maiden Gothic Lolita & Punk Brand Book V3 May 2006

[dog-lover22]

Title: Crazy about Alfie

Meanwhile, Alfie has no idea what's going on.

GLP: "Alfie, Alfie, Alfie, Alfie, Alfie, Alfie, Alfie, Alfie, Alfie, Alfie, Alfie, Alfie" etc.

I'm your protector! (A red flag right there)

Alfie from Bluey.

He'll never have Alfie because they're from different countries. Sorry.

Even though I don't draw the GLP; I got Inspired to do so, that's why I did it, and I had the idea for a while.

[eurofinsadvinus]

We can assist you with the Environmental Risk Assessment (ERA) of your medicinal products in a tiered approach as per EMA Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use. We conduct Phase I assessment, which includes the calculation of the Predicted Environmental Concentration (PECSW), and recommend studies to be performed in the Phase II Tier A assessment. For the PBT/vPvB assessment, we can determine the octanol/water partition coefficient. Based on the results, we suggest any additional studies that may be necessary. Our GLP laboratories can conduct all required studies for both ERA Phase II Tier A and Tier B, as well as the studies needed for PBT/vPvB assessments. Contact us to discuss your project requirements - bd@advinus.eurofinsasia.com

[pharmatechy]

Quality Control in Pharmaceutical Industry | QC in Pharma Company

The Quality Control department's major and important role is in the Pharmaceutical industry.

The main role of the quality control department in the pharma industry is to check the quality of various products, such as raw materials, in-process samples, and finished products.

Their main agenda is to analyse and control the quality of the products at all stages of the manufacturing of API or Formulations.

QC is done by the Qualitative and Quantitative analysis of specific materials as per Stanard Testing Procedures (STP) or Method of Analysis.

Generally, the QC department is divided into four sections. These are main

Raw Materials

In-process Quality Checks (IPQC)

Finished Products

Stability Studies

Raw materials:

The materials come from outside industries or suppliers and road tankers check the quality of the materials as per in-house specifications or Standard testing procedures. 

These are categorised into four parts.

General Raw materials:

These are some chemical analyses, like titrimetry, and chemical analysis methods, such as organic and inorganic acids, bases, salts, etc.

Ex: Hydrochloric acid(HCl), Sulphuric acid(H2SO4), Nitric acid(HNO3), Caustic soda(NaOH), Sodium carbonate(Na2CO3), Methanol, Toluene, Acetone, Dichloromethane etc…

Key Starting Materials (KSM):

These are the building blocks of drug intermediates or used to form the structure of compounds, APIs, or Drug substances. 

The sampling method is different from general raw materials.

These are analyzed with both chemical and instrumental analysis.

Ex: Speciality Fine Chemicals, Drug Intermediates etc.

Packing Materials:

PM is used for Products/Compound materials that are stored

Ex: Fibre drums, HDPE, LDPE drums, Polyethene bags, etc…

Hazardous Materials:

HM are harmful or affect body raw materials to handling in careful safety precautions and as per its Material Safety Data Sheets (MSDS) so vendors or suppliers give a certificate of analysis based on these are approved as per customer COAs.

Ex: Sodium Hydride(NaH), Sodium Amide(NaNH2), NaCN etc…

Some catalysts are also approved as per customer COAs

Ex: Raney-Nikel, Palladium/Carbon(Pd/C) used for Hydrogenation reaction.

In-Process samples:

Online chemical and instrumental methods analysis as per in-house specification & STPs carried out samples coming from the manufacturing blocks or production department to time to give results after the process continuously.

Finished Products:

Complete Analysis carried out as per customer or In-house or Pharmacopia specification and Standard Testing Procedures of the final products.

The analysis carried out in the Quality control department is divided into two parts. These are

Chemical Analysis Laboratory (Wet Lab)

Volumetric analysis:

Chemical labs have five types of titrimetric analysis

Acid-Base Titration Ex: Hydrochloric acid (HCl), Sodium Hydroxide (NaOH)

Argentometric titration Ex: Sodium Chloride(NaCl), Aluminum chloride (AlCl3)

Redox Titration Ex: Sodium thiosulphate, Potassium permanganate

Complexometric titration Ex: Calcium chloride (Cacl2), Magnesium (Mg) and Metals

Non-aqueous titration for Drug intermediates and APIs Ex: 2-Amino Pyridine, Isonipotic acid etc..

Gravimetric analysis:

Gravimetric analysis is the mass of an ion in a compound and is determined to find out the mass per cent of the same ion in a known quantity of a compound.

Examples 1) The amount of sulphate as barium sulphate(BaSO4) from sodium sulphate(NaSO4).

2) Content of Nickel in Raney-Nickle catalyst and Palladium in Pd/C catalyst.

Wet laboratory, some important chemical analyses are

Ex: Water content(WC), Loss on drying(LOD), Residue on ignition(ROI), Specific Optical Rotation(SOR), Wt per mL, Thin Layer Chromatography(TLC), Tapped density, Friebilty, Dissolution, Disintegration etc.

Water Analysis:

Softener water: This water is used for boiler purposes to generate steam.

Demineralized or Deionised water: This water is used for chemical analysis and process areas.

Purified water: This water is used for the manufacturing process.

Three samples are collected to be analysed to their specification (WHO) and Standard testing procedures as per scheduled.

Instrumental methods of Chemical analysis

1) Chromatography: 

Instrumental analysis to analyse quantitative and qualitative investigates analytes using the help of scientific instruments.

There are main two instrumental analyses carried out for Quality Control in the Pharmaceutical industry.

This technique separates and identifies the mixture of the compounds based on their relative affinity amounts of each compound distributed between a moving mobile phase, and a stationary phase. Mostly used instruments of Quality Control in the Pharmaceutical industry

          1) High-Performance Liquid Chromatography (HPLC)           2) Gas Chromatography (GC)

2) Spectrophotometry:

Spectroscopic techniques are to pass a beam of electromagnetic radiation onto an unknown sample and observe to find out the difference between energy levels with reference.

Most commonly used spectrophotometers of Quality Control in the Pharmaceutical industry. There are 

           1) Ultra-Violet Spectrophotometer (UVS)            2) Fourier-transform infrared spectrometer (FTIR) and NIR  3) Atomic Absorption Spectrometer (AAS) and FAS

These are the main used Research Centres for Structure elucidations and Analytical Method Development.

          1) Nuclear Magnetic Resonance Spectrometer (NMR)

          2) Mass Spectrometer (MS)

3) Thermo Gravimetric Analysis (TGA)

4) Differential Thermal Analysis (DTA)

Stability Studies:

Stability studies are conducted for a re-test or expiry or a shelf life period for the drug substance or the drug product and recommended storage conditions.

These are analysed as per protocol or stability STP based on the schedule.

           1) Hold-time stability studies            2) Long-term, Accelerated, intermediate condition studies

The quality control department follows systematic proper online documentation, Logbooks, Registers, Good Laboratory Practices (GLP) and Good Documentation Practices.

After complete analysis, documented respective analysis signed and checked authorised persons to prepare the certificate of analysis approved by the Head of the department or Designee.

Backup Electronic Data:

All electronic data stored in their servers or external hard disks are Empower network or Lab solution or Open Lab software and its data is backed up and retrieved every week by an IT person.

 Conclusion:

The Quality Control department checks each step of the product manufacturing as per specification and standard testing procedures after releasing documented data.

[newstotalcomunicacao]

Petrobras produz 2,7 milhões de barris de petróleo no 3º trimestre

A Petrobras registrou produção de 2,689 milhões de barris de óleo equivalente por dia (boed).O número representa uma queda em relação ao trimestre anterior (2,699 milhões boed) e em relação ao terceiro trimestre de 2023 (2,880 milhões boed). A companhia colocou como destaques operacionais mais recentes o alcance do topo de produção do FPSO Sepetiba, no campo de Mero e a entrada de novos poços em…