#genesis neurogen

[genesis8]

Who is the Best Gynecologist in Delhi and Gurgaon - Dr. Radha Jain

When it comes to women's health, having a caring and skilled gynecologist is super important. Dr. Radha Jain is one of the Best Gynecologist in East Delhi , and Gurgaon working at Genesis Neurogen. She's known for her dedication to providing great care and making sure her patients feel supported.

Dr. Radha Jain's Background:

Dr. Radha Jain MBBS, DGO is the Senior Consultant Gynecologist & Obstetrician in Delhi provides a great deal of women's health care treatments.

But, locating, coordinating and placing trust in any healthcare professional especially a gynecologist in our town may appear difficult eventually, but when one goes through the set of outstanding achievements and encouraging patients’ reviews and accolades, our doubt s bound to dispel. The fact holds truth for Dr. Radhika Jain, Best Gynecologist In East Delhi serving Delhiites since 2002 while running Genesis Neurogen, a healthcare point enjoying wider popularity across East Delhi

Complete Women's Health Services:

At Genesis Neurogen, Dr. Radha Jain offers lots of different services for women. From regular check-ups to handling more complicated health issues, she wants to make sure each patient gets the care they need.

Before and After Pregnancy Care: Dr. Radha Jain is really good at helping soon-to-be moms. She guides them through each step of pregnancy, making sure everything is going well. After the baby is born, she keeps taking care of both mom and baby.

Gynecological Surgeries: Dr. Radha Jain is skilled at doing different kinds of surgeries to help with women's health. Whether it's a small surgery or a bigger one, she makes sure it's done well and keeps her patients safe.

Handling Reproductive Health Issues: Dr. Radha Jain knows a lot about fixing problems with women's reproductive health. This includes issues with periods, hormones, and even helping with getting pregnant. She works with each person to find the best way to help.

Teen Girl Health: Dr. Radha Jain understands that teenage girls have their own special needs. She helps them with care that's right for their age, making sure they feel comfortable talking about anything that's bothering them.

Putting Patients First:

What makes Dr. Radha Jain really stand out is how much she cares about her patients. She believes in making a strong connection with each person, so they feel comfortable talking to her. Being kind and understanding, she creates a safe space for women during their health journey.

Conclusion:

Dr. Radha Jain is one of the Best Gynecologists in East Delhi at Genesis Neurogen because she cares so much about women's health. She offers many services, always does her best, and puts her patients first. If you're looking for a gynecologist who's both skilled and caring, Dr. Radha Jain is the right choice for your health journey.

Call - 011-22378802, 7481909090

Reference - https://qr.ae/pKmRqQ

[genesisoxysleep]

Occupational Therapy Centre in Shahdara

Are you looking for an Occupational Therapy center in Shahdara? Look no further than Genesis Neurogen! Our dedicated team offers personalized therapy to help you or your loved ones gain independence and improve daily living skills. With our expert care and modern facilities, we support a wide range of needs and age groups. At Genesis Neurogen, your progress is our priority

Click here for more info - Occupational Therapy Centre in Shahdara

[genesisnesurogen]

Best Gynecologist In East Delhi

Are you want to book online appointment with gynecologist in East Delhi? Then contact Dr. Radha Jain, who is available at Genesis Neurogen Krishna Nagar. She is Senior Consultant Gynecologist & Obstetrician.

Contact For More Information: 011-22001122, 7504001122

[biomedres]

Open Access Journals on Surgery - BJSTR Journal

Anti-Epileptic Drugs, Would They be the Cause of Heterotopic Ossification by  Saloua Khalfaoui in Biomedical Journal of Scientific & Technical Research https://biomedres.us/fulltexts/BJSTR.MS.ID.002040.php?ts=1612498665#/ Etiopathogenesis of Heterotopic ossification or paraosteoarthropathy is unknown, all speculations remain open. Epilepsy and anti-epileptic drugs have never been mentioned as a risk factor. We report the case of an epileptic patient operated several times for fracture of the right humeral head. He was treated by anti-epileptic (Valproic Acid). He developed a stiffness of the right shoulder. Imaging showed a heterotopic ossification. Through this observation, we have tried to answer the question of the origin of the appearance of the heterotopic ossification; this genesis is multifactorial with a role of the anti-epileptic whose Valproic Acid. Heterotopic ossification (HO) or paraosteoarthropathy is called neurogenic when it occurs as a result of central or peripheral nervous system involvement. A HO may also occur in a context of bone trauma or burns or in an orthopedic context [1]. Epilepsy and anti-epileptic drugs (AEDs) have never been mentioned as a risk factor.Case Description Fore more articles on Open Access Journals on Surgery please click here bjstr Follow on Twitter : https://twitter.com/Biomedres01 Follow on Blogger : https://biomedres01.blogspot.com/ Like Our Pins On : https://www.pinterest.com/biomedres/

[juniperpublisherscasestudies]

Juniper Publishers- Open Access Journal of Case Studies

Serum Leukocytes in Patients with Keloid

Authored by Felipe Contoli Isoldi

Abstract

Background: The mechanisms underlying the pathogenesis of keloids have not been fully characterized. Results of past and present studies have shown that the immune system is actively involved in the development of these lesions. The occurrence of leukocyte infiltration into keloid tissue, and increase in serum immunoglobulinshave been demonstrated; however, no study to date has evaluated serum leukocyte counts and leukocyte distribution in patients with keloids.

Materials and methods: Samples of venous blood were collected from 21 patients with keloids and 20 patients with normotrophic scars for total and differential leukocyte counts.

Results: There were no significant differences neither in mean total leukocyte counts (p<0.343), nor in differential leukocyte counts (neutrophil, p<0.444; eosinophil, p<0.620; basophil p<0.515; monocyte, p<0.688; and lymphocyte, p<0.439) between groups.

Conclusion: No quantitative and qualitative differences were found in leukocytes counts between patients with and without keloids. This confirms the fact that keloid scarring is not an intrinsic disturbance that results in increased cell proliferation. According to this view, keloid scarring may be regarded as an inflammatory disturbance related more to cellular hypermetabolism than to cell hyperproliferation.

Keywords: Keloid; Inflammation; Leukocytes; Leukocytes Count; Wound Healing

Introduction

Keloid formation results from a disturbance in wound healing caused by an imbalance between collagen synthesis and degradation; however, the mechanisms underlying keloid pathogenesis are not well understood [1]. Keloids are benign neoplasms that grow beyond the boundaries of the original wound. They do not regress spontaneously, and have a high recurrence rate after excision, even when the procedure is combined with other treatment modalities. The condition is characterized by pruritus, pain and hyperemia, suggesting an intermittent, local inflammatory process [2].

An increase in the metabolic activity of fibroblasts, and consequent increase in collagen synthesis, may occur due to a prolonged chronic inflammatory process [3]. This process is characterized at the cellular level by an increase in neutrophils, mast cells, lymphocytes and macrophages [4,5]. In this context, Hazrati & Hoomand [6] observed by microscopy a significantly higher tissue infiltration by these inflammatory cells in keloids than in spinocellular carcinoma. These authors also demonstrated the association between local lymphocytic infiltration and serum lymphocytosis, and exacerbation of immediate and delayed hypersensitivity skin reactions in patients with keloids [7,8].

The relationship between keloid and the immune system [4,7] becomes more important in patients with keloids and high serum IgE levels [8]. This immunoglobulin induces mast cell degranulation, which triggers proinflammatory signaling, which in turn will induce collagen deposition [7].

Immunoglobulins G, M and A, and the C3, C4 and C1q complement components have been associated with keloid formation; however, there is divergence in the literature concerning their level variation in patients with keloids [4,5]. On the other hand, it has been established that atopic patients are more susceptible to develop keloids [9].

Despite the fact that all evidences point to a relationship between the immune system and the pathogenic mechanisms of keloids, no studies were found in the literature evaluating serum leukocyte counts in patients with keloids. Therefore, the aim of this study was to investigate serum leukocyte counts and leukocyte distribution in patients with keloids.

Materials and Methods

This controlled study was conducted with 41 patients who attended the Plastic Surgery Outpatient Clinic of the Federal University of São Paulo. Participants were selected and divided into two groups: Keloid Group (KG: n=21; 6 men; median age, 29 years), and Control Group (CG: n=20; 14 men; median age, 23 years).

The keloid group consisted of patients with keloid scars located on the trunk, including the region between the transverse plane at the level of the sternoclavicular joint and transverse plane at the level of the upper margin of the pubic symphysis, comprising the whole-body perimeter. Patients with keloids of more than 1-year duration, which were showing clinical activity, such as pruritus, pain and hyperemia, alone or in combination, were included in this group. The control group included patients with normotrophic scars of more than 1-year duration, without past or current keloid or hypertrophic scars. Patients with treated or recurrent keloids of less than 1-year duration following previous excision, collagen disorders, malignant neoplasia, or those who underwent chemotherapy or corticoid treatment were excluded from the sample.

All patients responded to a medical history questionnaire, which also included questions on the characteristics of the keloid (location, presence of local pruritus, pain and hyperemia, causes of keloid formation, and keloid duration) and history of atopy. Scar pain and pruritus were measured using a visual analogue scale (VAS) rated from 0 (no symptom) to 10 (maximum symptom intensity) [10]. After, a venous blood sample was taken from the forearm of each patient for total and differential leukocyte counts. All laboratory tests were performed by the Central Laboratory at the Federal University of São Paulo Hospital (Unifesp).

Student’s t-test was used to compare the mean absolute count of each leukocyte cell type (neutrophils, eosinophils, basophils, monocytes, and lymphocytes) at a significance level of 0.05 (p < 0.05).

The present study was approved by the Research Ethics Committee of the Federal University of São Paulo (Unifesp), Brazil, and was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki. Written informed consent was obtained from all patients. Patient anonymity was assured.

Results

With regard to atopy, 24.4% of the patients in the keloid group and 17.1% of the patients in the control group had allergic rhinitis and contact dermatitis according to the medical history questionnaire.

There were no significant differences either in mean total leukocyte counts or differential leukocyte counts (neutrophils, eosinophils, basophils, monocytes, and lymphocytes) between groups (Table 1).

Discussion

The present study was based on the work of Hazrati & Hoomand [6], who raised the hypothesis that patients with keloids did not have the tendency to develop spinocellular carcinoma and viceversa. This proposition was based on inflammatory parameters; the authors observed increased lymphocyte count in the serum and tissue of patients with keloids, and exacerbation of immediate and delayed hypersensitivity skin reactions in patients with skin carcinoma. Their study was conducted with 68 patients.

When compared with patients with normal skin, patients with keloids have increased levels of immunoglobulins, complement components, and pro-inflammatory cells [3,4,7,8], as in the lymphocyte infiltrate, containing high concentrations of T-cells (CD3+, CD4+, CD45RO+, and HLA-DR+), dendritic cells (CD1a+, CD36+, HLA-DR+, and ICAM-1+), macrophages, and mast cells [4,5,7]. This increase in cell number definitely demonstrated that the immune system is constantly active [4], recruiting elements for regulation of inflammation in the keloid tissue [1,2]. These phenomena imply that the existence of a systemic inflammatory state would provide an appropriate microenvironment for keloid formation and growth [2].

Keloid fibroblasts produce more collagen than normal skin fibroblasts [1,2]. However, there are no differences in growth and proliferation between keloid and normotrophic scar fibroblasts [11]. Therefore, the increased collagen production in keloids is related to an increase in fibroblast activity, characterizing a hyperactive state of these cells, which results in higher energy consumption [12]. Hyperactivity of fibroblasts is associated with deregulation of cytokines, interleukins, and growth factors (especially TGF-beta) [2], which have proven to induce keloid growth. Hence, after its development, the keloid itself creates a self-perpetuating cycle [2].

However, in the present study, there were no significant differences in the total and differential leukocyte counts between patients with and without keloids. These results confirm the fact that keloid scarring is not an intrinsic disturbance that results in increased cell proliferation, as demonstrated with respect to keloid fibroblasts (no quantitative differences between keloid and normal skin fibroblasts were detected). Keloid fibroblasts show increased activity, resulting in increased collagen synthesis, rather than increased proliferation. According to this view, keloid scarring should be regarded more as a disturbance in cellular hypermetabolism than as a disturbance in cell hyperproliferation [1,13]. This may explain the results with respect to serum leukocytes.

In comparison with the control group, the keloid group had a higher prevalence of atopy, pruritus, pain, and hyperemia, of which pruritus was the most frequent symptom. This is in agreement with the literature [1,9]. These symptoms are indicative of a neurogenic inflammatory activity intrinsic to the keloid that is represented by the presence of a large number of nociceptive nerve endings in this tissue [14], higher levels of proinflammatory neuropeptides, such as CGRP [15], and a functional disturbance of this innervation [14,15].

Although the presence of the Immune System in the genesis and maintenance of the inflammatory process involved in keloid is verified at serum and histological levels, leukocytes quantification in the peripheral blood was not altered. Even when the keloid presented exacerbated clinical symptoms. The present study suggests that further research is necessary to investigate differences in a possible systemic inflammatory state, either in the level of cell signaling or gene expression, in patients with keloids.

Conclusion

In conclusion, there are no quantitative and qualitative differences in serum leukocyte counts in patients with keloids.

For more articles in Open Access Journal of Case Studies please click on: https://juniperpublishers.com/jojcs/index.php

[draloksharma01-blog]

Genesis - NeuroGen Brain and Spine Institute At Mumbai, Dr Alok Sharma and his team of highly experienced doctors use a combination of cell therapy and neurorehabilitation.

[draloksharmastemcell-blog]

At Genesis - NeuroGen Brain and Spine Institute At Mumbai, Dr Alok Sharma and his team of highly experienced doctors use a combination of cell therapy and neurorehabilitation. Dr Alok Sharma's comprehensive treatment involves a holistic approach towards the total wellbeing of the patient which through and improvement in their neurological condition, which ultimately helps in the quality of a better life.

[flauntpage]

What is Thoracic Outlet Syndrome?

I’ve heard the same things everybody else has.

Markelle Fultz has apparently been to something like 10 specialists in an effort to discover what’s wrong with his shoulder. Only yesterday did we finally get a diagnosis for the shoulder issue that ails him, a diagnosis of “Thoracic Outlet Syndrome.”

TOS, in simple terms, is a compression of the Thoracic Outlet located in the area between the lower neck and upper chest. That “outlet” consists of the Brachial Plexus and an artery and vein located just below the clavicle.

Here’s a handy diagram, courtesy of Hopkins Medicine, that shows the area in question:

The circled area is the Thoracic Outlet, which contains the Plexus (yellow), the subclavian artery (red), and the subclavian vein (blue). The Brachial Plexus is basically a network of nerves that extends from your spinal cord through your neck and over the ribcage into your armpit. While nerves are present in this area, TOS isn’t considered a “nerve issue,” it’s categorized as a group of disorders and not one specific thing.

There is, however, a bit of discrepancy in the language used by the Sixers and Markelle’s agent, Raymond Brothers, because in the press release the team says he has “Thoracic Outlet Syndrome” while Brothers told Adrian Wojnarowski that Markelle has “Neurogenic Thoracic Outlet Syndrome,” which would suggest that the compression is on the nerve bundle and not the veins. A “vascular” TOS would be the compression of those veins instead, which is easier to diagnose than the neurogenic variety because the patient would have altered pulsations or more identifiable blood vessel issues. The neurogenic version of TOS is said to be more common but harder to diagnose.

People with TOS will suffer from their collarbone, chest muscle, or neck muscle pushing against one or more of the aforementioned vessels or nerves, which results in pain in the neck and shoulders or a numbness and weakness that shoots down to the hand and fingers. The sensations are inconsistent and TOS presents itself in a somewhat erratic way.

You may remember The Athletic report that came out about two weeks ago, a combo effort from Jared Weiss, Derek Bodner, and Sam Amick. In that write up, it’s mentioned that Fultz was also dealing with a wrist injury, and this passage jumps out at me specifically:

In addition to a previously diagnosed right shoulder injury that continues to impact him, Fultz has been playing with an apparent injury in his right wrist area that has adversely affected his ability to shoot, league sources told The Athletic. The issue has led to periodic difficulties holding on to the ball during his shot. Specialists have been working with Fultz to figure out how they can strengthen the wrist area to remedy the injury.

….

The wrist and shoulder injuries’ impact varies; some days they badly hinder him, other days they do not, causing an erratic pattern in which his shot appears to be working one game and is off the next. As he tries to work through and compensate for the injury, it has at times resulted in a case of the ‘yips,’ especially when shooting free throws.

That would mesh with the symptoms of TOS, the idea that if Markelle was feeling numbness or tingling in his hands via the impacted nerves or veins, that he would have trouble gripping a ball or making consistent shooting motions due to wonky compression patterns. I don’t know how that manifests itself when Markelle goes up to block a shot or dunk the basketball with one hand, but those motions do not feature the same muscle usage as shooting a basketball with two hands.

Over at Philly.com, Sarah Todd talked to California pain management specialist Medhat Mikhael, and I found this passage interesting regarding the difficulty and length that it takes to correctly diagnose TOS:

“…a lot of the time there are physicians that miss the diagnosis. I’ve seen patients treated in so many ways and seen patients that ended up with a neck surgery or fusion surgery because they thought something else was causing the patient’s symptoms and they went ahead an operated and then the patient continued to have the symptoms. A lot of times patients will rush into treatment thinking that they know the cause, thinking that’s it’s coming from a certain point, but it is not.”

TOS is categorized as a diagnosis of exclusion, which means that you’ve basically ruled out everything else to reach your conclusion. A good example of a similar diagnosis is Irritable Bowel Syndrome, which can involve a number of different signs and symptoms. Maybe you get a colonoscopy or an upper GI endoscopy, and the doctor doesn’t find anything. You’re in the clear. No diverticulitis, no colon cancer, nothing like that. They just circle back to an IBS diagnosis because they don’t see anything conclusive in the testing. You’ve basically just gone through a process of elimination, and it can take a long time to get there.

At this point, I’m more interested in the cause of Markelle’s problem, which we still don’t have an explanation for. We don’t know how this happened. Did it stem from the scapular muscle imbalance? If so, where did the scapular muscle imbalance come from? We’ve asked Bryan Colangelo, Brett Brown, and Elton Brand about the genesis of the injury, which they claim they do not know. We asked Markelle about it last year, and he responded with total silence while staring into the abyss. The theory that he hurt himself in a bike accident was squashed publicly by Raymond Brothers. Do you believe Brothers or not? The whole thing is bizarre.

According to the Mayo Clinic, these are some possible causes of TOS:

Anatomical defects. Inherited defects that are present at birth (congenital) may include an extra rib located above the first rib (cervical rib) or an abnormally tight fibrous band connecting your spine to your rib.

Poor posture. Drooping your shoulders or holding your head in a forward position can cause compression in the thoracic outlet area.

Trauma. A traumatic event, such as a car accident, can cause internal changes that then compress the nerves in the thoracic outlet. The onset of symptoms related to a traumatic accident often is delayed.

Repetitive activity. Doing the same thing repeatedly can, over time, wear on your body’s tissue. You may notice symptoms of thoracic outlet syndrome if your job requires you to repeat a movement continuously, such as typing on a computer, working on an assembly line or lifting things above your head, as you would if you were stocking shelves. Athletes, such as baseball pitchers and swimmers, also can develop thoracic outlet syndrome from years of repetitive movements.

Pressure on your joints. Obesity can put an undue amount of stress on your joints, as can carrying around an oversized bag or backpack.

I’d imagine any early medical scan would have revealed an anatomical defect. Markelle is certainly not obese and I don’t think he was lugging around oversized bags at Washington or in high school.

Trauma would make the most sense, but you would leave the door open for “repetitive activity” wearing on the body. If Fultz took 40 bazillion shots this summer with Drew Hanlen, did that uber-training ultimately turn out to be counterproductive to his health?

I’ve said before that we have Fultz, Brown, and Brand on record within the past 30 days, each saying that Markelle was fine. He himself never complained about shoulder issues this year, and if he said something internally, like “coach I don’t feel right,” then the Sixers obviously complied with that because he’s seen multiple different specialists over the past however many weeks and months. That’s the whole point of allowing second and third and fourth opinions via the collective bargaining agreement, so that NBA teams can’t just say, “you feel fine, get your ass out on the court.” 

I also don’t really buy the fact that the Sixers medical staff is completely inept. Athletic team doctors are generally specialized in, well, athletic injuries. They’re good with knees and elbows and backs, common issues basketball players suffer from. How much does Dr. Danny Medina really know about Zhaire Smith’s sesame seed allergy? Probably jack shit, so they outsource the medical analysis to an allergy specialist and will generally send a team doctor along for any visits. It’s not like they just say, “okay, we’re gonna send you to a shoulder specialist, let us know how it goes!” They are a part of the process from start to finish.

Likewise, when you go to your primary care physician for a throat problem, he or she will likely send you to an ENT specialist who knows what they’re talking about. The world of athletic medicine isn’t entirely different from what you and I experience.

Again, what I’m interested in is this:

“Markelle, what do you think is the cause of this Thoracic Outlet Syndrome?”

That’s really the most important question moving forward. I’m skeptical that three to six weeks of physical therapy will fix all of his problems, but I’m not cheering against the kid, not at all. Something about all of this just feels “incomplete” to me.

The post What is Thoracic Outlet Syndrome? appeared first on Crossing Broad.

What is Thoracic Outlet Syndrome? published first on https://footballhighlightseurope.tumblr.com/

[stdlist]

Neurosyphilis

Neurosyphilis is an infectious lesion of the Central nervous system caused by the penetration of syphilis pathogens into it. It can occur in any period of syphilis. Neurosyphilis is manifested by symptoms of meningitis, meningovascular pathology, meningomyelitis, lesions of the posterior ropes and roots of the spinal cord, progressive paralysis or focal brain damage due to the formation of syphilitic gum in it. Diagnosis of neurosyphilis is based on the clinical picture, data of neurological and ophthalmological examination, MRI and CT of the brain, positive serological reactions to syphilis and the results of the study of liquor. Treatment of neurosyphilis is carried out intravenously with large doses of penicillin.

Until a few decades ago, neurosyphilis was a very common complication of syphilis. However, mass examinations of patients for syphilis, timely detection and treatment of infected persons have led to the fact that modern venereology is less likely to face such a form of disease as neurosyphilis, despite the fact that the incidence of syphilis is steadily growing. Many authors also believe that the decline in cases of neurosyphilis associated with changes in pathogenic characteristics of its causative agent — Treponema pallidum — including a reduction of its neirotropnami.

Classification of neurosyphilis

Latent neurosyphilis has no clinical manifestations, but the study of the patient's cerebrospinal fluid revealed pathological changes.

Early neurosyphilis develops against the background of primary or secondary syphilis, mainly in the first 2 years of the disease. But it can occur within 5 years from the time of infection. Proceeds with the defeat of mainly blood vessels and brain membranes. The manifestations of early neurosyphilis include acute syphilitic meningitis, meningovascular neurosyphilis and syphilitic meningomyelitis.

Late neurosyphilis occurs not earlier than 7-8 years from the moment of infection and corresponds to the period of tertiary syphilis. It is characterized by inflammatory and dystrophic lesions of the brain parenchyma: nerve cells and fibers, glia. To the late forms of neurosyphilis include tabes dorsalis, progressive paralysis, and syphilitic Gumma of the brain.

Symptoms of neurosyphilis

Acute syphilitic meningitis is characterized by symptoms of acute meningitis: severe headache, tinnitus, nausea and vomiting, regardless of food intake, dizziness. Often occurs without raising body temperature. Positive meningeal symptoms: rigidity of muscles of neck, lower symptom Brudzinskogo and Kernig's signs. There may be an increase in intracranial pressure. Neurosyphilis in the form of acute meningitis develops most often in the first few years of syphilis, during its relapse. It may be accompanied by skin rashes or be the only manifestation of a relapse of secondary syphilis.

Meningovascular neurosyphilis develops in syphilitic lesions of the vessels of the brain by the type of endarteritis. Is manifested by acute disruption of blood flow in brain in ischemic or hemorrhagic stroke, a few weeks before which the patient begins to disturb headaches, sleep disturbances, dizziness, personality changes. It is possible for meningovascular neurosyphilis with a violation of cerebrospinal circulation and the development of lower paraparesis, sensitivity disorders and disorders of the pelvic organs.

Syphilitic meningomyelitis occurs with damage to the membranes and substance of the spinal cord. There is a slowly increasing spastic lower paraparesis, accompanied by loss of deep sensitivity and dysfunction of the pelvic organs.

Spinal dryness occurs due to syphilitic inflammatory lesions and degeneration of the posterior roots and spinal cord ropes. This form of neurosyphilis occurs on average 20 years after infection. It is characterized by radiculitis with severe pain syndrome, loss of deep reflexes and deep types of sensitivity, sensitive ataxia, neuro-trophic disorders. With neurosyphilis in the form of spinal dryness, impotence may develop. There are neurogenic trophic ulcers on the legs and arthropathy. Characteristic syndrome Argyll-Robertson — irregular shape constricted pupils that do not react to light. The above symptoms may persist after specific therapy of neurosyphilis.

Progressive paralysis may appear in patients with 10-20-year-old disease. This variant of neurosyphilis is associated with the direct penetration of pale treponem into the brain cells, followed by their destruction. Manifests itself in a gradually increasing personality changes, memory impairment, thought disorder until the occurrence of dementia. Often there are mental disorders such as depressive or manic conditions, hallucinatory syndrome, delusional ideas. Neurosyphilis in the form of progressive paralysis may be accompanied by epileptic seizures, dysarthria, violation of pelvic functions, intentional tremor, decreased muscle strength and tone. Perhaps a combination with the manifestations of tabes dorsalis. Typically, patients with similar symptoms of neurosyphilis die within a few years.

Syphilitic gum is localized most often at the base of the brain, which leads to compression of the roots of the cranial nerves with the development of paresis of the oculomotor nerves, atrophy of the optic nerves, hearing loss, etc.as the gum grows in size, intracranial pressure increases and signs of compression of the brain substance increase. Less often, gum in neurosyphilis is located in the spinal cord, leading to the development of lower paraparesis and dysfunction of the pelvic organs.

Diagnosis of neurosyphilis

The diagnosis of neurosyphilis is made taking into account 3 main criteria: the clinical picture, the positive results of studies on syphilis and the detected changes in the cerebrospinal fluid. The correct assessment of the clinic of neurosyphilis is possible only after a neurologist complete neurological examination of the patient. Important additional information for the diagnosis of neurosyphilis gives vision examination and examination of the fundus, which is carried out by the ophthalmologist.

Laboratory tests for syphilis are used in a complex and, if necessary, repeatedly. These include the RPR test, REEF, RIBT, detection of pale Treponema with the content of skin elements (if any). In the absence of symptoms of compression of the brain, a patient with neurosyphilis is carried out a lumbar puncture. The study of cerebrospinal fluid neurosyphilis detects Treponema pallidum, increased protein content, inflammatory cell count in excess of 20 µl. Conducting a REEF with liquor, as a rule, gives a positive result.

MRI of the brain and CT of the brain (or spinal cord) with neurosyphilis detect mainly nonspecific pathological changes in the form of thickening of the meninges, hydrocephalus, atrophy of the brain substance, heart attacks. With their help, it is possible to identify the localization of gum and differentiate neurosyphilis from other similar diseases in the clinic.

Differential diagnosis of neurosyphilis is carried out with meningitis of other Genesis, vasculitis, brucellosis, sarcoidosis, borreliosis, tumors of the brain and spinal cord, etc.

Treatment of neurosyphilis

Therapy of neurosyphilis is carried out in stationary conditions by intravenous administration of large doses of penicillin for 2 weeks. Intramuscular penicillin therapy does not provide sufficient concentration of antibiotic in cerebrospinal fluid. Therefore, when failing intravenous therapy intramuscular administration of penicillins combine with taking probenecid, which inhibits the excretion of penicillin by the kidneys. In patients with neurosyphilis, allergic to penicillin, Ceftriaxone is used.

In the first day of treatment of neurosyphilis may occur temporary worsening of neurological symptoms, accompanied by a rise in body temperature, intense headache, tachycardia, hypotension, arthralgia. In such cases, penicillin therapy of neurosyphilis is supplemented with the appointment of anti-inflammatory and corticosteroid drugs.

The effectiveness of treatment is evaluated by regression of symptoms of neurosyphilis and improvement of cerebrospinal fluid. Control of treatment of patients with neurosyphilis is carried out for 2 years by examining the cerebrospinal fluid every six months. The emergence of new neurological symptoms or the growth of old, as well as the persisting cytosis in the liquor are indications for repeated treatment of neurosyphilis.

Sousres:

https://abuse-drug.com/disease/syphilis/syphilis-symptoms

https://www.ninds.nih.gov/Disorders/All-Disorders/Neurosyphilis-Information-Page

[genesis8]

Gynecologist in East Delhi

Your search for a trusted Gynecologist in East Delhi, ends with Dr. Radha Jain, experience compassionate women's health care and expert guidance tailored to your needs. Dr. Radha Jain prioritizes your well-being, providing comprehensive and personalized solutions. Take the first step towards your reproductive health journey – book your appointment now.

Click here for more info - Gynecologist in East Delhi

[genesisoxysleep]

Gynaecology & Obstetrics Centre in East Delhi

Looking for a place for women's health in East Delhi ? Check out Genesis Neurogen! We offer care for women's needs, like pregnancy and routine check-ups. Our team is kind and will make a plan just for you. We have good tools and people who know what they're doing. Your health is important to us. Call us today to make an appointment.

Click here for more info- Gynaecology & Obstetrics Centre in East Delhi

[genesisneurogenrishabhvihar]

Best Pediatrician in East Delhi

Dr. Dr Piyush Jain has been serving as the best pediatrician doctor in east Delhi for more than 20 years at Genesis Neurogen. He has got special interest in neonatology and Pediatric Neurology. Genesis Neurogen is situated in East Delhi with all the super best facilities and services. Pediatrics is the branch of prescription that includes the therapeutic care of new born babies, child, youngsters, and youths. He is working with great passion for the upliftment of these children to bring them to the main stream of society.

[genesisnesurogen]

Best Pediatrician In East Delhi

Are you want to book online appointment with pediatrician in East Delhi? Then contact Dr. Piyush Jain, who is available at Genesis Neurogen Krishna Nagar. He has more then 20 years experienced in giving medical services at affordable price.

[genesisspecialeducation-blog]

The Best Special Educator near Karkardooma and Krishna Nagarworks with the children through a customized plan to bring the positive changes. There is no single way to learn or get the therapy. The various elements of the therapy are mixed in an interesting way to help the child get the needed services.

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stammering is completely curable with an effectivespeech therapy by Dr MurliSingh

The Best stammering therapist treatment in Delhi starts after completely evaluating the current speech level of the person and the degree of its disfluency or fluency. The services also help the person with misarticulation, mispronunciation, and stuttering, which is an America word for stammering, etc. The speech therapist takes several steps and gradually brings a change in the behaviour of the person affected with speech defects. The therapy does not use any medicine or drugs, but several exercises are incorporated in the speech therapy plan depending on the degree of fluency or disfluency of the person.

 The several exercises include breathing exercises, jaw, neck, tongue and lip exercises. The aim of these exercises is to relax the organs of speech. The exercises also curb the secondary features, which are associated with the speech defects. The secondary features include the closing of the eye while forcing speech out of the mouth, movement of the neck, and movement of hands or just shaking legs or some other similar action. The secondary features vary from person to person and generally happen without any control over them. The removal of secondary features is the first step in gaining the confidence to speak without any disfluency.

 After breathing and mouth organ exercises, the reading from a book is recommended to stabilize the speech and correct articulation problems. The reading is guided in the slow and rhythmic style which uses the proper breathing techniques while reading. Then gradually the same reading style is adopted in the speech. The sessions conducted by the Best speech therapist in Delhi help the client to forget old defective speaking style and adopt a new style which is defect free.The duration of the therapy depends on the severity of the problem and the ability of the client to get into new tension-free speech.In the beginning, the client has to speak in slow elongated style, but with adequate practice, the normal speaking style comes automatically.

Dr Murli Singh is currently working in Genesis -Neurogen as H.O.D. Speech therapy &Audiology Department. He can also be contacted for misarticulation, stuttering, voice disorders, cleft palsy, delayed Speech and language, Aphasia, Hearing test, Hearing aid, Cerebral palsy,  Aphasia, Paralysis, brain stroke, and other speech Related problem.

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Dr Alok Sharma Stem Cell Therapy, At Gensis Neurogen Dr Alok Sharma and his highly experienced team, has treated patients with stem cell therapy and neurorehabilitation which helps in the quality of life better